psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I549	R:R:T545	4.56	Yes	No	1	8	9
2	R:R:F623	R:R:T545	5.19	Yes	No	0	6	9
3	R:R:N703	R:R:T545	4.39	Yes	No	1	7	9
4	R:R:A548	R:R:N546	4.69	No	No	0	9	9
5	R:R:L566	R:R:N546	6.87	No	No	0	9	9
6	R:R:F547	R:R:S570	5.28	Yes	No	0	9	7
7	R:R:F547	R:R:L619	3.65	Yes	No	0	9	9
8	R:R:F547	R:R:W773	3.01	Yes	Yes	1	9	9
9	R:R:F547	R:R:F791	5.36	Yes	Yes	1	9	9
10	R:R:A548	R:R:Q788	7.58	No	Yes	0	9	8
11	R:R:I549	R:R:N703	11.33	Yes	Yes	1	8	7
12	R:R:I549	R:R:W705	3.52	Yes	Yes	1	8	9
13	R:R:F643	R:R:L550	7.31	Yes	No	1	8	9
14	R:R:L550	R:R:W705	6.83	No	Yes	1	9	9
15	R:R:F716	R:R:L550	3.65	Yes	No	1	9	9
16	R:R:F716	R:R:M551	4.98	Yes	No	1	9	9
17	R:R:M551	R:R:W773	5.82	No	Yes	1	9	9
18	R:R:F791	R:R:M551	4.98	Yes	No	1	9	9
19	R:R:L556	R:R:Q552	3.99	No	No	6	4	9
20	R:R:Q552	R:R:Q788	3.84	No	Yes	6	9	8
21	R:R:I713	R:R:V553	3.07	Yes	No	7	8	8
22	R:R:V553	R:R:W714	9.81	No	Yes	7	8	8
23	R:R:L556	R:R:Q788	3.99	No	Yes	6	4	8
24	R:R:L558	R:R:Q563	5.32	No	No	0	5	4
25	R:R:L558	R:R:Q788	3.99	No	Yes	0	5	8
26	R:R:H562	R:R:V785	6.92	No	No	0	7	5
27	R:R:H562	R:R:Y789	9.8	No	Yes	0	7	9
28	R:R:A565	R:R:Y789	4	No	Yes	0	6	9
29	R:R:L566	R:R:Y789	7.03	No	Yes	0	9	9
30	R:R:I569	R:R:T793	3.04	No	No	0	9	5
31	R:R:F623	R:R:S570	6.61	Yes	No	0	6	7
32	R:R:F623	R:R:Y571	10.32	Yes	No	0	6	7
33	R:R:G573	R:R:V572	3.68	No	No	0	9	5
34	R:R:G573	R:R:S796	3.71	No	No	0	9	9
35	R:R:G573	R:R:L797	3.42	No	No	0	9	7
36	R:R:C574	R:R:Q616	6.1	No	No	0	8	8
37	R:R:C574	R:R:L620	9.52	No	No	0	8	8
38	R:R:L576	R:R:L800	5.54	No	No	0	5	6
39	R:R:L581	R:R:S577	3	Yes	No	5	9	9
40	R:R:Q616	R:R:S577	8.66	No	No	0	8	9
41	R:R:G799	R:R:S577	3.71	No	No	5	8	9
42	R:R:L613	R:R:V578	2.98	No	No	0	8	7
43	R:R:V578	R:R:V617	3.21	No	No	0	7	5
44	R:R:C580	R:R:L800	3.17	No	No	0	7	6
45	R:R:C580	R:R:F803	6.98	No	Yes	0	7	9
46	R:R:L581	R:R:T584	2.95	Yes	Yes	5	9	9
47	R:R:L581	R:R:S609	3	Yes	No	5	9	8
48	R:R:L581	R:R:V612	2.98	Yes	No	0	9	8
49	R:R:L581	R:R:L613	5.54	Yes	No	0	9	8
50	R:R:G799	R:R:L581	5.13	No	Yes	5	8	9
51	R:R:L613	R:R:V582	2.98	No	No	0	8	4
52	R:R:A583	R:R:F803	4.16	No	Yes	0	6	9
53	R:R:S609	R:R:T584	3.2	No	Yes	5	8	9
54	R:R:F803	R:R:T584	5.19	Yes	Yes	5	9	9
55	R:R:C807	R:R:T584	6.76	No	Yes	5	8	9
56	R:R:L585	R:R:S609	3	No	No	0	7	8
57	R:R:L591	R:R:T587	2.95	Yes	No	0	8	8
58	R:R:C807	R:R:T587	5.07	No	No	0	8	8
59	R:R:F588	R:R:Y602	9.28	No	Yes	0	7	8
60	R:R:L591	R:R:V590	2.98	Yes	No	0	8	4
61	R:R:V590	R:R:W824	3.68	No	No	0	4	7
62	R:R:A816	R:R:L591	3.15	No	Yes	0	8	8
63	R:R:K820	R:R:S593	4.59	No	No	0	8	8
64	R:R:T596	R:R:V594	3.17	No	No	3	9	8
65	R:R:I597	R:R:V594	3.07	Yes	No	3	8	8
66	R:R:A816	R:R:V594	5.09	No	No	3	8	8
67	R:R:I597	R:R:T596	3.04	Yes	No	3	8	9
68	R:R:E812	R:R:T596	8.47	No	No	0	8	9
69	R:R:I597	R:R:Y602	9.67	Yes	Yes	3	8	8
70	R:R:A816	R:R:I597	3.25	No	Yes	3	8	8
71	R:R:N599	R:R:R601	12.05	No	No	3	8	8
72	R:R:N599	R:R:Y602	9.3	No	Yes	3	8	8
73	R:R:H656	R:R:Q600	7.42	Yes	No	2	8	8
74	R:R:H672	R:R:Q600	19.78	No	No	0	7	8
75	R:R:Q600	R:R:Y675	4.51	No	Yes	2	8	8
76	R:R:R601	R:R:Y602	15.43	No	Yes	3	8	8
77	R:R:E812	R:R:R601	8.14	No	No	0	8	8
78	R:R:N810	R:R:Y602	3.49	No	Yes	3	9	8
79	R:R:V813	R:R:Y602	3.79	No	Yes	3	9	8
80	R:R:H603	R:R:Y676	9.8	No	Yes	0	8	8
81	R:R:I604	R:R:W649	5.87	Yes	Yes	2	9	9
82	R:R:I604	R:R:V652	7.68	Yes	Yes	2	9	8
83	R:R:E653	R:R:I604	6.83	No	Yes	2	9	9
84	R:R:H656	R:R:I604	5.3	Yes	Yes	2	8	9
85	R:R:E653	R:R:H605	13.54	No	No	2	9	9
86	R:R:H605	R:R:I768	3.98	No	Yes	2	9	8
87	R:R:H605	R:R:H806	3.58	No	No	2	9	9
88	R:R:N607	R:R:W649	19.21	No	Yes	2	9	9
89	R:R:N607	R:R:Y676	12.79	No	Yes	2	9	8
90	R:R:N607	R:R:W680	4.52	No	Yes	2	9	8
91	R:R:L608	R:R:W649	3.42	No	Yes	0	9	9
92	R:R:L608	R:R:M650	4.24	No	No	0	9	9
93	R:R:F610	R:R:V614	5.24	No	No	0	4	6
94	R:R:Q616	R:R:V612	5.73	No	No	0	8	8
95	R:R:Q798	R:R:V612	2.87	No	No	0	9	8
96	R:R:F642	R:R:V614	9.18	No	No	0	8	6
97	R:R:A615	R:R:F643	8.32	No	Yes	0	9	8
98	R:R:L618	R:R:L638	4.15	No	No	0	7	7
99	R:R:F623	R:R:L619	9.74	Yes	No	0	6	9
100	R:R:L619	R:R:L639	4.15	No	Yes	0	9	9
101	R:R:I621	R:R:M635	2.92	No	No	0	4	6
102	R:R:L625	R:R:S622	3	No	Yes	4	4	8
103	R:R:M635	R:R:S622	4.6	No	Yes	4	6	8
104	R:R:L639	R:R:S622	3	Yes	Yes	0	9	8
105	R:R:C704	R:R:S622	3.44	Yes	Yes	4	9	8
106	R:R:L625	R:R:M635	7.07	No	No	4	4	6
107	R:R:C704	R:R:L625	6.35	Yes	No	4	9	4
108	R:R:T629	R:R:T630	3.14	Yes	No	4	8	3
109	R:R:P631	R:R:T629	10.49	No	Yes	4	6	8
110	R:R:P631	R:R:T630	5.25	No	No	4	6	3
111	R:R:C632	R:R:C704	7.28	No	Yes	4	9	9
112	R:R:G699	R:R:Q633	3.29	No	No	0	8	5
113	R:R:A636	R:R:Y698	4	No	Yes	0	9	9
114	R:R:V637	R:R:Y698	5.05	No	Yes	0	4	9
115	R:R:F642	R:R:L638	3.65	No	No	0	8	7
116	R:R:F643	R:R:L639	4.87	Yes	Yes	0	8	9
117	R:R:L639	R:R:W705	3.42	Yes	Yes	0	9	9
118	R:R:H640	R:R:L644	9	Yes	Yes	1	9	9
119	R:R:C687	R:R:H640	5.9	No	Yes	0	8	9
120	R:R:H640	R:R:S690	5.58	Yes	No	1	9	8
121	R:R:H640	R:R:L706	7.71	Yes	No	0	9	9
122	R:R:A715	R:R:H640	2.93	No	Yes	0	9	9
123	R:R:F716	R:R:H640	3.39	Yes	Yes	1	9	9
124	R:R:F642	R:R:Y641	6.19	No	Yes	0	8	7
125	R:R:W680	R:R:Y641	8.68	Yes	Yes	0	8	7
126	R:R:L684	R:R:Y641	3.52	No	Yes	0	5	7
127	R:R:C687	R:R:Y641	4.03	No	Yes	0	8	7
128	R:R:F643	R:R:F716	5.36	Yes	Yes	1	8	9
129	R:R:L644	R:R:P683	3.28	Yes	Yes	0	9	8
130	R:R:I686	R:R:L644	5.71	No	Yes	0	7	9
131	R:R:F716	R:R:L644	4.87	Yes	Yes	1	9	9
132	R:R:S645	R:R:W680	7.41	No	Yes	0	8	8
133	R:R:P683	R:R:S645	3.56	Yes	No	0	8	8
134	R:R:F647	R:R:F716	3.22	Yes	Yes	0	9	9
135	R:R:A720	R:R:F647	8.32	No	Yes	0	9	9
136	R:R:F647	R:R:V723	7.87	Yes	No	0	9	8
137	R:R:F647	R:R:W773	16.04	Yes	Yes	0	9	9
138	R:R:A648	R:R:P683	3.74	No	Yes	0	7	8
139	R:R:V652	R:R:W649	7.36	Yes	Yes	2	8	9
140	R:R:W649	R:R:Y676	6.75	Yes	Yes	2	9	8
141	R:R:G679	R:R:W649	4.22	No	Yes	0	9	9
142	R:R:W649	R:R:W680	14.06	Yes	Yes	2	9	8
143	R:R:G770	R:R:M650	3.49	No	No	0	9	9
144	R:R:M650	R:R:Q798	5.44	No	No	0	9	9
145	R:R:L651	R:R:M678	4.24	Yes	No	0	9	7
146	R:R:L651	R:R:V723	4.47	Yes	No	0	9	8
147	R:R:L651	R:R:V726	2.98	Yes	No	0	9	8
148	R:R:V652	R:R:Y675	8.83	Yes	Yes	2	8	8
149	R:R:M678	R:R:V652	4.56	No	Yes	0	7	8
150	R:R:E653	R:R:I768	9.56	No	Yes	2	9	8
151	R:R:G654	R:R:I730	3.53	No	No	0	9	8
152	R:R:H656	R:R:M660	7.88	Yes	No	0	8	8
153	R:R:H656	R:R:Y675	8.71	Yes	Yes	2	8	8
154	R:R:L657	R:R:V661	2.98	No	No	8	9	9
155	R:R:L657	R:R:V734	5.96	No	No	8	9	9
156	R:R:L657	R:R:L765	4.15	No	No	0	9	9
157	R:R:I662	R:R:Y658	12.09	Yes	No	0	8	8
158	R:R:I730	R:R:Y658	6.04	No	No	0	8	8
159	R:R:S659	R:R:S667	3.26	No	No	0	8	8
160	R:R:M660	R:R:S667	6.13	No	No	0	8	8
161	R:R:V661	R:R:V734	4.81	No	No	8	9	9
162	R:R:A733	R:R:I662	3.25	No	Yes	0	8	8
163	R:R:I662	R:R:V734	3.07	Yes	No	0	8	9
164	R:R:I662	R:R:V737	3.07	Yes	No	0	8	8
165	R:R:H672	R:R:S670	5.58	No	No	0	7	7
166	R:R:K671	R:R:Y675	10.75	No	Yes	0	8	8
167	R:R:W680	R:R:Y676	3.86	Yes	Yes	2	8	8
168	R:R:F682	R:R:M678	4.98	No	No	0	4	7
169	R:R:L691	R:R:S690	3	No	No	1	4	8
170	R:R:S690	R:R:Y698	5.09	No	Yes	1	8	9
171	R:R:L691	R:R:Y698	4.69	No	Yes	1	4	9
172	R:R:F693	R:R:S692	5.28	No	No	0	5	6
173	R:R:S697	R:R:S707	4.89	No	No	0	7	8
174	R:R:S697	R:R:S710	6.52	No	No	0	7	4
175	R:R:A712	R:R:S697	3.42	No	No	0	7	7
176	R:R:N703	R:R:W705	3.39	Yes	Yes	1	7	9
177	R:R:L706	R:R:W705	13.67	No	Yes	0	9	9
178	R:R:F716	R:R:W705	8.02	Yes	Yes	1	9	9
179	R:R:I713	R:R:L708	4.28	Yes	No	0	8	7
180	R:R:I713	R:R:W714	3.52	Yes	Yes	7	8	8
181	R:R:V717	R:R:W714	4.9	No	Yes	0	8	8
182	R:R:L721	R:R:V717	2.98	No	No	0	7	8
183	R:R:F722	R:R:V726	7.87	No	No	0	5	8
184	R:R:N727	R:R:V723	2.96	No	No	0	9	8
185	R:R:I724	R:R:I728	2.94	No	Yes	0	9	5
186	R:R:L769	R:R:N727	10.98	No	No	0	9	9
187	R:R:I728	R:R:T771	4.56	Yes	No	0	5	8
188	R:R:L731	R:R:T735	2.95	No	No	0	8	9
189	R:R:T735	R:R:T758	3.14	No	No	9	9	8
190	R:R:S739	R:R:T758	6.4	No	No	0	8	8
191	R:R:L757	R:R:S742	4.5	No	No	0	8	8
192	R:R:F805	R:R:V764	3.93	No	No	0	8	8
193	R:R:H806	R:R:V764	4.15	No	No	0	9	8
194	R:R:L765	R:R:L769	6.92	No	No	0	9	9
195	R:R:L766	R:R:P767	3.28	No	No	0	8	9
196	R:R:F801	R:R:P767	2.89	Yes	No	0	8	9
197	R:R:I768	R:R:L769	4.28	Yes	No	0	8	9
198	R:R:H806	R:R:I768	13.26	No	Yes	2	9	8
199	R:R:L794	R:R:S772	7.51	No	No	0	6	9
200	R:R:N795	R:R:S772	10.43	No	No	0	9	9
201	R:R:F791	R:R:W773	8.02	Yes	Yes	1	9	9
202	R:R:N795	R:R:W773	15.82	No	Yes	1	9	9
203	R:R:Q798	R:R:W773	6.57	No	Yes	0	9	9
204	R:R:F775	R:R:M790	8.71	No	No	0	8	5
205	R:R:F791	R:R:G776	7.53	Yes	No	0	9	9
206	R:R:F787	R:R:L778	7.31	No	No	0	7	7
207	R:R:C783	R:R:N781	3.15	No	No	0	4	7
208	R:R:A784	R:R:F787	4.16	No	No	0	6	7
209	R:R:F791	R:R:N795	9.67	Yes	No	1	9	9
210	R:R:F801	R:R:L794	3.65	Yes	No	0	8	6
211	R:R:F801	R:R:L797	3.65	Yes	No	0	8	7
212	R:R:F801	R:R:F805	3.22	Yes	No	0	8	8
213	R:R:C807	R:R:F803	8.38	No	Yes	5	8	9
214	R:R:F803	R:R:L808	4.87	Yes	No	0	9	7
215	R:R:N810	R:R:V813	5.91	No	No	3	9	9
216	R:R:R814	R:R:S811	3.95	No	No	0	9	8
217	R:R:H819	R:R:V823	5.54	No	No	0	8	7
218	R:R:K820	R:R:W824	11.6	No	No	0	8	7
219	R:R:I713	R:R:L706	2.85	Yes	No	0	8	9
220	R:R:I549	R:R:N546	2.83	Yes	No	0	8	9
221	R:R:L651	R:R:L655	2.77	Yes	No	0	9	7
222	R:R:L731	R:R:L765	2.77	No	No	0	8	9
223	R:R:L800	R:R:L804	2.77	No	No	0	6	8
224	R:R:L808	R:R:L809	2.77	No	No	0	7	8
225	R:R:F647	R:R:I724	2.51	Yes	No	0	9	9
226	R:R:I732	R:R:R736	2.51	No	No	0	4	7
227	R:R:F787	R:R:M790	2.49	No	No	0	7	5
228	R:R:F817	R:R:L591	2.44	No	Yes	0	7	8
229	R:R:F682	R:R:L685	2.44	No	No	0	4	5
230	R:R:F775	R:R:L794	2.44	No	No	0	8	6
231	R:R:I569	R:R:Y789	2.42	No	Yes	0	9	9
232	R:R:G681	R:R:P683	2.03	No	Yes	0	9	8
233	R:R:C632	R:R:P627	1.88	No	No	4	9	5
234	R:R:C704	R:R:P627	1.88	Yes	No	4	9	5
235	R:R:A718	R:R:P719	1.87	No	No	0	7	9
236	R:R:G628	R:R:T629	1.82	No	Yes	0	7	8
237	R:R:A611	R:R:A646	1.79	No	No	0	8	7
238	R:R:A694	R:R:A712	1.79	No	No	0	6	7
239	R:R:A779	R:R:A784	1.79	No	No	0	8	6
240	R:R:P555	R:R:V554	1.77	No	No	0	6	8
241	R:R:G729	R:R:I728	1.76	No	Yes	0	5	5
242	R:R:G799	R:R:I802	1.76	No	No	0	8	8
243	R:R:A611	R:R:S645	1.71	No	No	0	8	8
244	R:R:G782	R:R:N781	1.7	No	No	0	3	7
245	R:R:C632	R:R:T629	1.69	No	Yes	4	9	8
246	R:R:I686	R:R:P719	1.69	No	No	0	7	9
247	R:R:D669	R:R:G666	1.68	No	No	0	6	7
248	R:R:L708	R:R:P555	1.64	No	No	0	7	6
249	R:R:S567	R:R:S568	1.63	No	No	0	7	5
250	R:R:S701	R:R:S707	1.63	No	No	0	3	8
251	R:R:A761	R:R:I738	1.62	No	No	0	9	9
252	R:R:V554	R:R:V780	1.6	No	No	0	8	7
253	R:R:V582	R:R:V586	1.6	No	No	0	4	6
254	R:R:V717	R:R:V777	1.6	No	No	0	8	7
255	R:R:V774	R:R:V777	1.6	No	No	0	5	7
256	R:R:S825	R:R:T821	1.6	No	No	0	8	8
257	R:R:T735	R:R:V762	1.59	No	No	9	9	8
258	R:R:T758	R:R:V762	1.59	No	No	9	8	8
259	R:R:A792	R:R:L566	1.58	No	No	0	8	9
260	R:R:A606	R:R:L585	1.58	No	No	0	7	7
261	R:R:E626	R:R:P627	1.57	No	No	0	2	5
262	R:R:I738	R:R:S739	1.55	No	No	0	9	8
263	R:R:M790	R:R:V786	1.52	No	No	0	5	5
264	R:R:F665	R:R:G666	1.51	No	No	0	8	7
265	R:R:L620	R:R:S575	1.5	No	No	0	8	7
266	R:R:L579	R:R:V578	1.49	No	No	0	4	7
267	R:R:N703	R:R:S701	1.49	Yes	No	0	7	3
268	R:R:I728	R:R:I732	1.47	Yes	No	0	5	4
269	R:R:G677	R:R:Y676	1.45	No	Yes	0	5	8
270	R:R:G699	R:R:Y698	1.45	No	Yes	0	8	9
271	R:R:L691	R:R:M695	1.41	No	No	0	4	2
272	R:R:G711	R:R:W714	1.41	No	Yes	0	7	8
273	R:R:K760	R:R:L757	1.41	No	No	0	9	8
274	R:R:A763	R:R:F805	1.39	No	No	0	7	8
275	R:R:D669	R:R:K671	1.38	No	No	0	6	8
276	R:R:I741	R:R:Q740	1.37	No	No	0	8	8
277	R:R:R560	R:R:V564	1.31	No	No	0	1	5
278	R:R:K663	R:R:Y658	1.19	No	No	0	7	8
279	R:R:R673	R:R:Y674	1.03	No	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F547	4.325	4	1	9
2	R:R:I549	5.56	4	1	8
3	R:R:L581	3.76667	6	5	9
4	R:R:T584	4.525	4	5	9
5	R:R:L591	2.88	4	0	8
6	R:R:I597	4.7575	4	3	8
7	R:R:Y602	8.49333	6	3	8
8	R:R:I604	6.42	4	2	9
9	R:R:S622	3.51	4	4	8
10	R:R:F623	7.965	4	0	6
11	R:R:T629	4.285	4	4	8
12	R:R:L639	3.86	4	0	9
13	R:R:H640	5.75167	6	1	9
14	R:R:Y641	5.605	4	0	7
15	R:R:F643	6.465	4	1	8
16	R:R:L644	5.715	4	1	9
17	R:R:F647	7.592	5	0	9
18	R:R:W649	8.69857	7	2	9
19	R:R:L651	3.615	4	0	9
20	R:R:V652	7.1075	4	2	8
21	R:R:H656	7.3275	4	2	8
22	R:R:I662	5.37	4	0	8
23	R:R:Y675	8.2	4	2	8
24	R:R:Y676	6.93	5	2	8
25	R:R:W680	7.706	5	2	8
26	R:R:P683	3.1525	4	0	8
27	R:R:Y698	4.056	5	1	9
28	R:R:N703	5.15	4	1	7
29	R:R:C704	4.7375	4	4	9
30	R:R:W705	6.475	6	1	9
31	R:R:I713	3.43	4	7	8
32	R:R:W714	4.91	4	7	8
33	R:R:F716	4.78429	7	1	9
34	R:R:I728	2.6825	4	0	5
35	R:R:I768	7.77	4	2	8
36	R:R:W773	9.21333	6	1	9
37	R:R:Q788	4.85	4	6	8
38	R:R:Y789	5.8125	4	0	9
39	R:R:F791	7.112	5	1	9
40	R:R:F801	3.3525	4	0	8
41	R:R:F803	5.916	5	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A548	R:R:N546	16.3817	4.69	No	No	0	9	9
2	R:R:I549	R:R:N546	40.107	2.83	Yes	No	0	8	9
3	R:R:L566	R:R:N546	22.1662	6.87	No	No	0	9	9
4	R:R:F547	R:R:L619	15.3649	3.65	Yes	No	0	9	9
5	R:R:I549	R:R:W705	42.8862	3.52	Yes	Yes	1	8	9
6	R:R:L639	R:R:W705	20.351	3.42	Yes	Yes	0	9	9
7	R:R:L619	R:R:L639	13.7154	4.15	No	Yes	0	9	9
8	R:R:F716	R:R:W705	84.1606	8.02	Yes	Yes	1	9	9
9	R:R:F716	R:R:M551	54.666	4.98	Yes	No	1	9	9
10	R:R:M551	R:R:W773	41.4928	5.82	No	Yes	1	9	9
11	R:R:F647	R:R:F716	78.7	3.22	Yes	Yes	0	9	9
12	R:R:F647	R:R:W773	62.4539	16.04	Yes	Yes	0	9	9
13	R:R:F791	R:R:M551	13.2711	4.98	Yes	No	1	9	9
14	R:R:A548	R:R:Q788	13.6326	7.58	No	Yes	0	9	8
15	R:R:L706	R:R:W705	35.0757	13.67	No	Yes	0	9	9
16	R:R:I713	R:R:L706	47.104	2.85	Yes	No	0	8	9
17	R:R:I713	R:R:W714	23.8156	3.52	Yes	Yes	7	8	8
18	R:R:L566	R:R:Y789	16.7131	7.03	No	Yes	0	9	9
19	R:R:G573	R:R:L797	10.9287	3.42	No	No	0	9	7
20	R:R:F801	R:R:L797	14.5439	3.65	Yes	No	0	8	7
21	R:R:F801	R:R:L794	28.9448	3.65	Yes	No	0	8	6
22	R:R:L794	R:R:S772	47.8647	7.51	No	No	0	6	9
23	R:R:N795	R:R:S772	50.8398	10.43	No	No	0	9	9
24	R:R:N795	R:R:W773	38.6307	15.82	No	Yes	1	9	9
25	R:R:F791	R:R:N795	15.2143	9.67	Yes	No	1	9	9
26	R:R:Q616	R:R:V612	11.5538	5.73	No	No	0	8	8
27	R:R:Q798	R:R:V612	100	2.87	No	No	0	9	8
28	R:R:Q798	R:R:W773	93.1385	6.57	No	Yes	0	9	9
29	R:R:L581	R:R:V612	89.1466	2.98	Yes	No	0	9	8
30	R:R:L581	R:R:T584	65.0825	2.95	Yes	Yes	5	9	9
31	R:R:F803	R:R:T584	17.6169	5.19	Yes	Yes	5	9	9
32	R:R:L581	R:R:L613	14.4536	5.54	Yes	No	0	9	8
33	R:R:C807	R:R:T584	46.1249	6.76	No	Yes	5	8	9
34	R:R:C807	R:R:T587	45.2437	5.07	No	No	0	8	8
35	R:R:L591	R:R:T587	43.082	2.95	Yes	No	0	8	8
36	R:R:I597	R:R:Y602	14.0092	9.67	Yes	Yes	3	8	8
37	R:R:A816	R:R:I597	20.9987	3.25	No	Yes	3	8	8
38	R:R:A816	R:R:L591	30.3608	3.15	No	Yes	0	8	8
39	R:R:V652	R:R:Y675	16.6679	8.83	Yes	Yes	2	8	8
40	R:R:M678	R:R:V652	14.1071	4.56	No	Yes	0	7	8
41	R:R:L651	R:R:M678	16.1633	4.24	Yes	No	0	9	7
42	R:R:L651	R:R:V723	21.3753	4.47	Yes	No	0	9	8
43	R:R:F647	R:R:V723	51.2089	7.87	Yes	No	0	9	8
44	R:R:H640	R:R:L706	34.8347	7.71	Yes	No	0	9	9
45	R:R:C687	R:R:H640	27.0392	5.9	No	Yes	0	8	9
46	R:R:C687	R:R:Y641	24.8399	4.03	No	Yes	0	8	7
47	R:R:W680	R:R:Y641	20.7276	8.68	Yes	Yes	0	8	7
48	R:R:F716	R:R:H640	54.8693	3.39	Yes	Yes	1	9	9
49	R:R:F716	R:R:L644	22.6934	4.87	Yes	Yes	1	9	9
50	R:R:L644	R:R:P683	16.5173	3.28	Yes	Yes	0	9	8
51	R:R:P683	R:R:S645	11.004	3.56	Yes	No	0	8	8
52	R:R:S645	R:R:W680	10.2809	7.41	No	Yes	0	8	8
53	R:R:W649	R:R:W680	23.5369	14.06	Yes	Yes	2	9	8
54	R:R:I604	R:R:W649	21.767	5.87	Yes	Yes	2	9	9
55	R:R:E653	R:R:I768	12.1488	9.56	No	Yes	2	9	8
56	R:R:I768	R:R:L769	13.5046	4.28	Yes	No	0	8	9
57	R:R:L769	R:R:N727	30.2252	10.98	No	No	0	9	9
58	R:R:N727	R:R:V723	31.4981	2.96	No	No	0	9	8
59	R:R:M650	R:R:Q798	25.1262	5.44	No	No	0	9	9
60	R:R:L608	R:R:M650	22.2339	4.24	No	No	0	9	9
61	R:R:F642	R:R:Y641	13.0978	6.19	No	Yes	0	8	7
62	R:R:F643	R:R:L639	12.4501	4.87	Yes	Yes	0	8	9
63	R:R:F643	R:R:F716	16.4118	5.36	Yes	Yes	1	8	9
64	R:R:L639	R:R:S622	36.8909	3	Yes	Yes	0	9	8
65	R:R:C704	R:R:S622	24.8776	3.44	Yes	Yes	4	9	8
66	R:R:C632	R:R:C704	15.6963	7.28	No	Yes	4	9	9
67	R:R:C632	R:R:T629	12.6459	1.69	No	Yes	4	9	8
68	R:R:S690	R:R:Y698	14.2276	5.09	No	Yes	1	8	9
69	R:R:H640	R:R:S690	22.5201	5.58	Yes	No	1	9	8
70	R:R:I662	R:R:V734	13.4594	3.07	Yes	No	0	8	9
71	R:R:L657	R:R:V734	15.041	5.96	No	No	8	9	9
72	R:R:L657	R:R:L765	18.5509	4.15	No	No	0	9	9
73	R:R:L765	R:R:L769	32.2588	6.92	No	No	0	9	9
74	R:R:H656	R:R:I604	18.2496	5.3	Yes	Yes	2	8	9
75	R:R:H656	R:R:M660	11.2224	7.88	Yes	No	0	8	8
76	R:R:K671	R:R:Y675	10.1755	10.75	No	Yes	0	8	8
77	R:R:N703	R:R:S701	16.7131	1.49	Yes	No	0	7	3
78	R:R:S701	R:R:S707	13.964	1.63	No	No	0	3	8
79	R:R:S697	R:R:S707	11.1998	4.89	No	No	0	7	8
80	R:R:I713	R:R:L708	15.749	4.28	Yes	No	0	8	7
81	R:R:V717	R:R:W714	15.847	4.9	No	Yes	0	8	8
82	R:R:F647	R:R:I724	12.1488	2.51	Yes	No	0	9	9
83	R:R:I724	R:R:I728	10.1604	2.94	No	Yes	0	9	5
84	R:R:L731	R:R:L765	12.9547	2.77	No	No	0	8	9
85	R:R:L731	R:R:T735	11.1094	2.95	No	No	0	8	9
86	R:R:F801	R:R:F805	14.8151	3.22	Yes	No	0	8	8
87	R:R:F775	R:R:L794	24.1922	2.44	No	No	0	8	6
88	R:R:F775	R:R:M790	20.7803	8.71	No	No	0	8	5
89	R:R:F787	R:R:M790	13.9113	2.49	No	No	0	7	5
90	R:R:L708	R:R:P555	11.7195	1.64	No	No	0	7	6
91	R:R:F547	R:R:W773	17.406	3.01	Yes	Yes	1	9	9
92	R:R:N703	R:R:W705	20.3209	3.39	Yes	Yes	1	7	9
93	R:R:L608	R:R:W649	21.8122	3.42	No	Yes	0	9	9
94	R:R:F805	R:R:V764	11.7948	3.93	No	No	0	8	8
95	R:R:V652	R:R:W649	10.6274	7.36	Yes	Yes	2	8	9
96	R:R:E653	R:R:I604	18.1743	6.83	No	Yes	2	9	9
97	R:R:H806	R:R:V764	12.5179	4.15	No	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7EPT_nogp

PDB Summary
PDB	7EPT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.87
Number of Linked Nodes	245
Number of Links	279
Number of Hubs	41
Number of Links mediated by Hubs	154
Number of Communities	9
Number of Nodes involved in Communities	67
Number of Links involved in Communities	90

Path Summary
Number Of Nodes in MetaPath	98
Number Of Links MetaPath	97
Number of Shortest Paths	40553
Length Of Smallest Path	3
Average Path Length	11.3666
Length of Longest Path	23
Minimum Path Strength	1.52333
Average Path Strength	5.51179
Maximum Path Strength	15.93
Minimum Path Correlation	0.7
Average Path Correlation	0.921892
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	50.9231
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.4917
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell surface receptor signaling pathway • multicellular organismal process • system process • nervous system process • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • intracellular organelle lumen • nuclear speck • ribonucleoprotein granule • intracellular organelle • nuclear body • nucleoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • intracellular organelle lumen • nuclear speck • ribonucleoprotein granule • intracellular organelle • nuclear body • nucleoplasm • organelle lumen • organelle • membraneless organelle • supramolecular complex • nuclear ribonucleoprotein granule • nuclear lumen • cytoplasm • cytosol • cell periphery • plasma membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q6QNK2
Sequence	>7EPT_nogp_Chain_R T N F A I L M Q V V P L E L A R G H Q V A L S S I S Y V G C S L S V L C L V A T L V T F A V L S S V S T I R N Q R Y H I H A N L S F A V L V A Q V L L L I S F R L E P G T T P C Q V M A V L L H Y F F L S A F A W M L V E G L H L Y S M V I K V F G S E D S K H R Y Y Y G M G W G F P L L I C I I S L S F A M D S Y G T S N N C W L S L A S G A I W A F V A P A L F V I V V N I G I L I A V T R V I S Q I S A F K L T A K A V A V L L P I L G T S W V F G V L A V N G C A V V F Q Y M F A T L N S L Q G L F I F L F H C L L N S E V R A A F K H K T K V W S L T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9V0U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9V0U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165

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