Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 10.105404
2A:A:H41 5.614516
3A:A:L44 9.8125429
4A:A:L45 6.63448
5A:A:L46 5.2625428
6A:A:K53 6.194549
7A:A:V214 5.1225416
8A:A:F219 5.62618
9A:A:H220 11.51754137
10A:A:M221 3.752548
11A:A:F222 13.50254137
12A:A:Q227 5.674529
13A:A:E230 5.575429
14A:A:R232 6.6575428
15A:A:K233 6.06333629
16A:A:W234 5.98571729
17A:A:F238 9.312529
18A:A:I244 4.7375428
19A:A:I245 4.02167647
20A:A:V247 4.2325447
21A:A:S250 3.72436
22A:A:Y253 7.86438
23A:A:L270 4.8875406
24A:A:D272 6.4175408
25A:A:F273 4.986509
26A:A:W277 8.848336146
27A:A:W281 8.40167695
28A:A:I285 3.7125407
29A:A:I288 5.63549
30A:A:L289 4.7875439
31A:A:F290 5.32667649
32A:A:L291 3.99438
33A:A:N292 5.0075449
34A:A:Q294 4.972536
35A:A:L297 3.006538
36A:A:I308 5.6975407
37A:A:F312 3.928508
38A:A:F315 11.848536
39A:A:Y318 8.3875436
40A:A:P321 4.67635
41A:A:E330 5.072533
42A:A:V334 2.625404
43A:A:K338 7.09535
44A:A:Y339 6.68667633
45A:A:R342 7.2975434
46A:A:F345 7.4725438
47A:A:Y358 6.096544
48A:A:Y360 7.236548
49A:A:H362 7.4875449
50A:A:F363 8.496535
51A:A:T364 5.276549
52A:A:D368 5.345449
53A:A:N371 6.072549
54A:A:R373 6.2925415
55A:A:R374 5.6275444
56A:A:F376 6.91714718
57A:A:R380 6.265417
58A:A:I383 4.3625418
59A:A:R385 9.354545
60A:A:M386 3.3025403
61A:A:H387 6.64518
62A:A:Q390 5.6225414
63A:A:Y391 7.25514
64A:A:L393 4.916518
65B:B:E10 5.26254158
66B:B:L14 5.75254158
67B:B:D27 5.7325408
68B:B:I37 3.565122
69B:B:V40 4.185403
70B:B:M45 3.7225474
71B:B:L51 4.42409
72B:B:H54 11.52754189
73B:B:K57 12.098599
74B:B:Y59 9.3425498
75B:B:M61 4.715456
76B:B:W63 6.05333657
77B:B:R68 11.415455
78B:B:L69 4.9425455
79B:B:K78 6.2525408
80B:B:L79 4.2425457
81B:B:I81 3.2425457
82B:B:K89 6.4075409
83B:B:V90 4.365455
84B:B:L95 3.9375458
85B:B:W99 9.58333609
86B:B:M101 5.0275409
87B:B:Y105 3.87406
88B:B:Y111 6.28404
89B:B:L117 3.9825429
90B:B:I123 3.5225406
91B:B:Y124 5.22167656
92B:B:E130 6.5325403
93B:B:H142 6.58829
94B:B:Y145 6.62714728
95B:B:F151 5.75667609
96B:B:L152 5.266503
97B:B:V158 3.59405
98B:B:T159 4.12529
99B:B:S161 8.09429
100B:B:D163 8.59529
101B:B:W169 9.106528
102B:B:T173 4.3875405
103B:B:Q176 8.3575424
104B:B:F180 7.96587
105B:B:H183 7.39857789
106B:B:D186 5.884529
107B:B:F199 7.635489
108B:B:V200 7.2975466
109B:B:C204 5.612527
110B:B:D205 5.994589
111B:B:K209 10.8975486
112B:B:L210 5.9225465
113B:B:W211 8.35667688
114B:B:Q220 7.784567
115B:B:H225 7.23143769
116B:B:I229 4.9425467
117B:B:I232 6.615468
118B:B:F235 6.433336116
119B:B:P236 6.394117
120B:B:F241 6.215666
121B:B:T243 5.952568
122B:B:S245 6.2469
123B:B:D247 8.002569
124B:B:T249 6.4675466
125B:B:R251 9.978568
126B:B:F253 6.235666
127B:B:L261 4.47254175
128B:B:Y264 5.43167605
129B:B:H266 8.12754104
130B:B:I269 4.2954104
131B:B:F278 6.975117
132B:B:R283 8.2465129
133B:B:L285 4.794116
134B:B:Y289 7.815717107
135B:B:D290 5.6425496
136B:B:N295 10.1725106
137B:B:W297 6.57254108
138B:B:D298 9.53254129
139B:B:L300 6.7454126
140B:B:K301 4.248336125
141B:B:R304 8.6354105
142B:B:H311 9.868579
143B:B:R314 10.508598
144B:B:L318 3.685676
145B:B:M325 5.24655
146B:B:V327 3.585476
147B:B:T329 4.8775478
148B:B:W332 9.11714799
149B:B:D333 9.43479
150B:B:F335 7.495404
151B:B:K337 8.276576
152B:B:W339 8.38167679
153B:B:N340 5.715409
154G:G:Y40 12.964116
155G:G:D48 5.57679
156G:G:L51 3.365406
157G:G:V54 3.8425406
158G:G:N59 6.3675409
159G:G:P60 6.8125459
160G:G:F61 5.31571758
161R:R:F547 4.384219
162R:R:L550 6.3025419
163R:R:L566 4.734509
164R:R:L581 4.16254239
165R:R:V594 2.775408
166R:R:R601 6.925618
167R:R:Y602 5.83718
168R:R:I604 5.2875419
169R:R:L608 3.9175409
170R:R:V612 3.252508
171R:R:L618 3.3875417
172R:R:L639 3.234519
173R:R:H640 6.40143719
174R:R:Y641 4.245617
175R:R:F642 6.44418
176R:R:L644 4.288519
177R:R:W649 9.49429719
178R:R:V652 6.0925418
179R:R:E653 10.3475419
180R:R:L657 4.365419
181R:R:M660 9.366518
182R:R:I662 5.65408
183R:R:V664 5.006519
184R:R:F665 7.06143718
185R:R:Y675 6.79518
186R:R:M678 3.8407
187R:R:W680 8.7075418
188R:R:P683 3.792518
189R:R:S697 3.265257
190R:R:Y698 6.66286719
191R:R:N703 6.385417
192R:R:C704 4.2925419
193R:R:W705 4.94444919
194R:R:L706 4.982519
195R:R:I713 2.3625418
196R:R:I738 2.97167619
197R:R:T758 2.3725408
198R:R:L765 3.97619
199R:R:I768 5.1025418
200R:R:W773 9.28857719
201R:R:Q788 3.828508
202R:R:F791 6.18167619
203R:R:F803 6.3125249
204R:R:H806 5.605419
205R:R:E812 6.2725418
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:F238 A:A:L44 27.867619.49YesYes299
2A:A:I244 A:A:L44 27.94615.71YesYes289
3A:A:I244 A:A:V287 87.95293.07YesNo086
4A:A:V287 A:A:W277 99.01464.9NoYes066
5A:A:D354 A:A:W277 99.58965.58NoYes036
6A:A:D354 A:A:Y358 99.69092.3NoYes034
7A:A:Y358 A:A:Y360 99.52.98YesYes448
8A:A:D378 A:A:Y360 99.800110.34NoYes478
9A:A:D378 A:A:I288 98.588312.59NoYes479
10A:A:I245 A:A:I288 98.13525.89YesYes479
11A:A:I245 A:A:L43 99.09824.28YesNo477
12A:A:L43 A:A:T242 99.59882.95NoNo078
13A:A:H41 A:A:T242 99.60875.48YesNo068
14A:A:H41 A:A:I383 98.99113.98YesYes168
15B:B:S84 G:G:F61 22.69925.28NoYes058
16B:B:S84 B:B:W63 22.81414.94NoYes057
17B:B:M61 B:B:W63 39.57834.65YesYes567
18B:B:C317 B:B:M61 39.94686.48NoYes076
19B:B:C317 B:B:S316 40.19143.44NoNo079
20B:B:S316 B:B:W332 40.31474.94NoYes099
21A:A:W281 B:B:W332 22.40754.69YesYes959
22A:A:C237 A:A:F238 18.69322.79NoYes089
23A:A:F273 A:A:V287 12.21113.93YesNo096
24A:A:L289 A:A:L291 13.07872.77YesYes398
25A:A:I285 A:A:L282 54.63372.85YesNo079
26A:A:N279 A:A:W281 57.41533.39NoYes085
27A:A:W281 B:B:D290 41.61755.58YesYes956
28A:A:H387 A:A:I383 99.45626.63YesYes188
29A:A:H387 R:R:M660 10017.07YesYes188
30A:A:Y391 R:R:M660 60.382413.17YesYes148
31A:A:L393 A:A:Y391 11.19014.69YesYes184
32A:A:Y391 R:R:L657 11.18745.86YesYes149
33R:R:M660 R:R:R601 39.39926.2YesYes188
34A:A:Y391 R:R:H656 38.17213.27YesNo148
35R:R:H656 R:R:R601 38.7645.64NoYes188
36A:A:L393 R:R:L765 10.79886.92YesYes189
37R:R:L657 R:R:L765 10.78774.15YesYes199
38B:B:L14 G:G:L19 10.65182.77YesNo089
39B:B:I18 G:G:L19 19.21612.85NoNo079
40B:B:I18 B:B:R22 20.28915.01NoNo076
41B:B:D290 B:B:G272 44.96061.68YesNo064
42B:B:D246 B:B:G272 44.90171.68NoNo094
43B:B:D246 B:B:S227 44.84485.89NoNo096
44B:B:S227 B:B:S245 25.63023.26NoYes669
45B:B:H225 B:B:S245 14.809312.55YesYes699
46B:B:H225 B:B:T243 21.22355.48YesYes698
47B:B:F241 B:B:T243 15.57983.89YesYes668
48B:B:F222 B:B:F241 11.041610.72NoYes686
49B:B:F222 B:B:Q220 32.451616.4NoYes687
50B:B:D258 B:B:Q220 30.490711.75NoYes077
51B:B:D247 B:B:S227 19.1582.94YesNo696
52B:B:D247 B:B:H225 14.81595.04YesYes699
53B:B:I229 B:B:S245 10.7563.1YesYes679
54B:B:I229 B:B:T243 10.61326.08YesYes678
55B:B:F253 B:B:T243 11.48885.19YesYes668
56B:B:F222 B:B:F253 22.080310.72NoYes686
57B:B:F253 B:B:R251 11.49485.34YesYes668
58B:B:D258 B:B:R22 27.413611.91NoNo076
59B:B:M325 G:G:F61 16.7713.73YesYes558
60B:B:M325 G:G:P49 31.27956.71YesNo057
61G:G:D48 G:G:P49 30.80324.83YesNo097
62G:G:D48 G:G:L51 17.13764.07YesYes096
63B:B:R283 G:G:L51 16.17614.86YesYes096
64B:B:L300 B:B:R283 12.580413.36YesYes1269
65B:B:L300 G:G:C41 11.8656.35YesNo067
66B:B:F235 G:G:C41 11.62382.79YesNo067
67G:G:D48 G:G:L50 12.31952.71YesNo799
68B:B:M45 G:G:L50 12.07954.24YesNo749
69B:B:M45 B:B:W339 10.87993.49YesYes749
70B:B:T321 B:B:W63 16.56110.92NoYes577
71B:B:D323 B:B:M325 16.21846.93NoYes575
72B:B:D323 B:B:T321 16.32095.78NoNo577
73B:B:G162 B:B:Y145 10.35028.69NoYes298
74B:B:G162 B:B:S161 10.22383.71NoYes299
75R:R:I768 R:R:L765 21.34172.85YesYes189
76R:R:E653 R:R:I768 20.690410.93YesYes198
77R:R:E653 R:R:L608 40.96015.3YesYes099
78R:R:L608 R:R:V612 30.44262.98YesYes098
79R:R:Q798 R:R:V612 25.31332.87NoYes098
80R:R:Q798 R:R:W773 49.93764.38NoYes099
81R:R:H656 R:R:Y675 76.87339.8NoYes188
82R:R:I604 R:R:Y675 48.18914.84YesYes198
83R:R:E653 R:R:I604 20.49265.47YesYes199
84R:R:I604 R:R:W649 27.77664.7YesYes199
85R:R:L608 R:R:W649 40.79724.56YesYes099
86R:R:V652 R:R:Y675 28.18376.31YesYes188
87R:R:V652 R:R:W649 27.73667.36YesYes189
88R:R:L608 R:R:M650 50.85372.83YesNo099
89R:R:M650 R:R:Q798 25.26744.08NoNo099
90R:R:G770 R:R:M650 25.26943.49NoNo099
91R:R:G770 R:R:W773 24.94912.81NoYes099
92R:R:W649 R:R:W680 14.266418.74YesYes198
93R:R:W680 R:R:Y641 12.61434.82YesYes187
94R:R:F791 R:R:W773 47.63478.02YesYes199
95R:R:A548 R:R:F791 37.93062.77NoYes099
96R:R:A548 R:R:Q788 36.95884.55NoYes098
97R:R:N546 R:R:Q788 26.26533.96NoYes098
98R:R:L566 R:R:N546 24.32224.12YesNo099
99B:B:W332 B:B:Y59 22.19466.75YesYes998
100A:A:L282 A:A:N279 57.451313.73NoNo098
101A:A:I244 A:A:I285 54.72155.89YesYes087
102A:A:C237 B:B:Y59 21.44114.03NoYes088
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7WU2
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRD1
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma1
PDB Resolution 2.8
Date 2022-04-27
D.O.I. 10.1038/s41586-022-04580-w
Net Summary
Imin 2.65
Number of Linked Nodes 841
Number of Links 1087
Number of Hubs 205
Number of Links mediated by Hubs 736
Number of Communities 26
Number of Nodes involved in Communities 298
Number of Links involved in Communities 460
Path Summary
Number Of Nodes in MetaPath 103
Number Of Links MetaPath 102
Number of Shortest Paths 6352012
Length Of Smallest Path 3
Average Path Length 39.2397
Length of Longest Path 63
Minimum Path Strength 1.16
Average Path Strength 6.12848
Maximum Path Strength 21.45
Minimum Path Correlation 0.7
Average Path Correlation 0.993093
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.27273
Average % Of Corr. Nodes 31.5752
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 61.3416
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7WU2_Chain_A
IEKQLQKDK QVYRATHRL LLLGADNSG KSTIVKFET KFQVDKVNF 
HMFDVGGQR DERRKWIQC FNDVTAIIF VVDSSDYNR LQEALNDFK 
SIWNNRWLR TISVILFLN KQDLLAEKV LAGKSKIED YFPEFARYT 
TPEDATPEP GEDPRVTRA KYFIRDEFL RISTASGDG RHYCYPHFT 
CAVDTENAR RIFNDCRDI IQRMHLRQY ELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WU2_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WU2_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ6QNK2
Sequence
>7WU2_Chain_R
TNFAILMQV VPLELARGH QVALSSISY VGCSLSVLC LVATLVTFA 
VLSSVSTIR NQRYHIHAN LSFAVLVAQ VLLLISFRL EPGTTPCQV 
MAVLLHYFF LSAFAWMLV EGLHLYSMV IKVFGSEDS KHRYYYGMG 
WGFPLLICI ISLSFAMDS YGTSNNCWL SLASGAIWA FVAPALFVI 
VVNIGILIA VTRVISQIS ADNYKIHGD PSAFKLTAK AVAVLLPIL 
GTSWVFGVL AVNGCAVVF QYMFATLNS LQGLFIFLF HCLLNSEVR 
AAFKHKT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EPTB2AdhesionAdhesionADGRD1Homo sapiens--Gs/&β;1/&γ;232022-05-1110.1038/s41586-022-04619-y
7WU2B2AdhesionAdhesionADGRD1Homo sapiens--Gs/&β;1/&γ;12.82022-04-2710.1038/s41586-022-04580-w




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WU2.zip



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