Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 6.31254174
2A:A:Y37 8.8254184
3A:A:F219 6.814508
4A:A:F222 11.07254197
5A:A:Q227 7.38419
6A:A:K233 6.09333619
7A:A:W234 6.092519
8A:A:I245 4.5925407
9A:A:L270 4.585406
10A:A:F273 6.94209
11A:A:W277 11.024206
12A:A:W281 13.2675415
13A:A:L282 3.1325409
14A:A:F312 4.33754148
15A:A:F315 8.3325406
16A:A:Y318 5.4585146
17A:A:Y339 3.735403
18A:A:F340 7.6765147
19A:A:R342 6.61754114
20A:A:E344 6.23754145
21A:A:F345 7.7525408
22A:A:Y360 7.9925408
23A:A:F363 5.55754115
24A:A:T364 6.4454219
25A:A:C365 3.2525408
26A:A:D368 6.444219
27A:A:R373 6.19754135
28A:A:F376 6.1785138
29A:A:Y391 6.954534
30A:A:L393 4.796508
31A:A:L394 4.3375408
32B:B:L7 3.2175408
33B:B:I18 4.4425427
34B:B:R22 5.9925426
35B:B:I37 5.62754122
36B:B:V40 4.108336123
37B:B:R52 6.91407
38B:B:H54 10.01599
39B:B:L55 5.83754186
40B:B:K57 12.925419
41B:B:Y59 5.9775418
42B:B:W63 8.1365237
43B:B:D76 6.0545189
44B:B:W82 9.65857799
45B:B:D83 7.7754178
46B:B:K89 5.5525499
47B:B:I93 5.405407
48B:B:L95 5.835168
49B:B:W99 8.40167609
50B:B:M101 6.715419
51B:B:Y105 4.378506
52B:B:Y111 7.6375404
53B:B:C114 5.814168
54B:B:Y124 6.7245166
55B:B:H142 8.095419
56B:B:Y145 6.21167618
57B:B:F151 4.42333619
58B:B:I157 5.69417
59B:B:T159 5.058519
60B:B:S160 5.5425456
61B:B:D163 6.64519
62B:B:C166 4.0475458
63B:B:L168 4.285406
64B:B:W169 7.28667618
65B:B:F180 8.086557
66B:B:T181 2.7925412
67B:B:H183 7.23659
68B:B:D186 6.73419
69B:B:V187 5.0875459
70B:B:S201 4.6075459
71B:B:K209 9.8475456
72B:B:L210 6.0225425
73B:B:W211 9.07333658
74B:B:D212 7.222529
75B:B:R219 7.7975425
76B:B:Q220 7.678527
77B:B:H225 6.77571729
78B:B:I232 5.095428
79B:B:F235 7.165676
80B:B:N237 7.275475
81B:B:F241 9.014526
82B:B:T243 6.625428
83B:B:D247 8.044529
84B:B:R251 10.712528
85B:B:F253 6.98333626
86B:B:D258 9.5975427
87B:B:L261 5.9075405
88B:B:Y264 8.026585
89B:B:F278 6.1975407
90B:B:R283 8.4445129
91B:B:Y289 6.36286787
92B:B:D298 8.36254129
93B:B:R304 7.2175405
94B:B:H311 7.044569
95B:B:R314 11.632518
96B:B:L318 5.1475406
97B:B:M325 5.30254105
98B:B:W332 11.9683619
99B:B:D333 6.902569
100B:B:F335 6.7425464
101B:B:K337 6.16566
102B:B:W339 9.42569
103G:G:L19 2.8409
104G:G:E22 4.7525429
105G:G:R27 5.81428
106G:G:D48 6.6075409
107G:G:E58 4.3754105
108G:G:N59 8.72409
109G:G:P60 8.25754109
110G:G:F61 5.541676108
111R:R:I549 5.56448
112R:R:L591 2.88408
113R:R:R601 10.3654158
114R:R:Y602 8.493336158
115R:R:I604 6.42439
116R:R:F623 7.965406
117R:R:L639 3.86409
118R:R:H640 5.75167649
119R:R:Y641 5.605407
120R:R:F643 6.465448
121R:R:L644 5.715449
122R:R:F647 7.592509
123R:R:W649 8.69857739
124R:R:L651 3.615409
125R:R:V652 7.1075438
126R:R:E653 9.165439
127R:R:H656 6.734538
128R:R:M660 10.465438
129R:R:I662 5.37408
130R:R:F665 5.79508
131R:R:Y675 8.2438
132R:R:Y676 6.93538
133R:R:W680 7.706538
134R:R:P683 3.1525408
135R:R:Y698 4.056509
136R:R:N703 5.15447
137R:R:C704 4.73754269
138R:R:W705 6.475649
139R:R:W714 4.91408
140R:R:F716 4.78429749
141R:R:I728 2.6825405
142R:R:L765 4.845409
143R:R:I768 7.77438
144R:R:W773 10.454549
145R:R:Q788 4.854248
146R:R:Y789 5.8125409
147R:R:F791 7.112549
148R:R:F801 3.3525408
149R:R:F803 5.9165259
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:N23 B:B:N88 11.02910.9NoNo077
2B:B:D76 B:B:S74 13.697810.31YesNo099
3B:B:H54 B:B:S74 13.70839.76YesNo099
4A:A:Y37 B:B:D76 13.36855.75YesYes1849
5A:A:R42 A:A:Y37 15.956718.52NoYes094
6A:A:F219 A:A:H41 17.03534.53YesNo086
7A:A:H41 A:A:I383 20.63193.98NoNo068
8A:A:H387 A:A:I383 21.18426.63NoNo088
9A:A:H387 A:A:M386 96.61833.94NoNo083
10A:A:M386 A:A:Q390 96.68135.44NoNo034
11A:A:Q390 R:R:R601 96.74375.84NoYes048
12R:R:R601 R:R:Y602 96.801915.43YesYes1588
13R:R:I597 R:R:Y602 97.39829.67NoYes088
14R:R:A816 R:R:I597 97.45483.25NoNo088
15R:R:A816 R:R:V594 99.16845.09NoNo088
16B:B:D312 R:R:V594 99.2074.38NoNo058
17B:B:D312 B:B:D333 99.24523.99NoYes059
18B:B:D333 B:B:H311 99.19765.04YesYes699
19B:B:H311 B:B:T329 98.56086.85YesNo098
20B:B:L318 B:B:T329 1004.42YesNo068
21B:B:L286 B:B:L318 37.38284.15NoYes076
22B:B:L286 B:B:V296 37.28564.47NoNo075
23B:B:L284 B:B:V296 37.1384.47NoNo055
24B:B:L284 B:B:V40 37.06952.98NoYes053
25B:B:V40 G:G:L51 30.75692.98YesNo036
26G:G:D48 G:G:L51 30.59884.07YesNo096
27G:G:D48 G:G:P49 30.4673.22YesNo097
28B:B:M325 G:G:P49 30.43496.71YesNo057
29B:B:M325 G:G:P60 14.81046.71YesYes1059
30B:B:Y85 G:G:P60 14.887411.13NoYes1049
31B:B:R68 B:B:Y85 29.739121.61NoNo054
32B:B:D83 B:B:R68 29.321411.91YesNo085
33B:B:M325 G:G:F61 15.34183.73YesYes1058
34B:B:Y85 G:G:F61 15.06616.19NoYes1048
35A:A:F222 A:A:R42 17.54413.21YesNo079
36A:A:F219 A:A:L43 15.86186.09YesNo087
37A:A:I245 A:A:L43 15.56915.71YesNo077
38A:A:F222 B:B:W99 19.139217.04YesYes079
39B:B:H142 B:B:T159 39.68935.48YesYes199
40B:B:C149 B:B:T159 34.10513.38NoYes189
41B:B:C149 B:B:T102 34.20958.45NoNo088
42B:B:C148 B:B:T102 34.10343.38NoNo068
43B:B:C148 B:B:R150 34.01286.96NoNo066
44B:B:H62 B:B:R150 16.319110.16NoNo066
45B:B:H62 B:B:Y105 16.61253.27NoYes066
46B:B:L69 B:B:Y105 26.2624.69NoYes056
47B:B:D83 B:B:L69 26.56655.43YesNo085
48B:B:H142 B:B:S161 38.035916.74YesNo199
49B:B:G162 B:B:S161 39.62153.71NoNo199
50B:B:G162 B:B:Y145 39.45425.79NoYes198
51A:A:W234 B:B:Y145 24.78974.82YesYes198
52A:A:R231 A:A:W234 25.04476NoYes099
53A:A:L272 A:A:R231 24.55567.29NoNo089
54B:B:Q75 B:B:W99 20.77357.67NoYes099
55B:B:K57 B:B:Q75 10.717210.85YesNo099
56B:B:K57 B:B:W332 10.938625.53YesYes199
57B:B:R314 B:B:W332 74.030921.99YesYes189
58B:B:Q75 B:B:Y59 10.77524.51NoYes098
59B:B:W332 B:B:Y59 63.06435.79YesYes198
60B:B:M101 B:B:Y145 52.4477.18YesYes198
61B:B:M101 B:B:Y59 52.68869.58YesYes198
62A:A:F290 A:A:I245 13.21043.77NoYes097
63A:A:F246 A:A:L272 24.30577.31NoNo098
64A:A:F246 A:A:L289 24.05733.65NoNo099
65A:A:F345 A:A:L289 23.808312.18YesNo089
66A:A:E344 A:A:F340 13.95248.16YesYes1457
67A:A:E344 A:A:L270 15.32093.98YesYes056
68A:A:F345 A:A:L270 18.32276.09YesYes086
69A:A:H387 R:R:M660 90.259217.07NoYes088
70A:A:Y391 R:R:M660 12.022610.78YesYes348
71R:R:H656 R:R:M660 77.93847.88YesYes388
72B:B:L192 B:B:R150 42.39926.07NoNo056
73B:B:L152 B:B:L192 42.14174.15NoNo035
74B:B:L152 B:B:Q156 41.62547.99NoNo035
75B:B:L168 B:B:Q156 41.36655.32YesNo065
76B:B:L168 B:B:T178 40.58694.42YesNo064
77B:B:F180 B:B:T178 40.32613.89YesNo074
78B:B:F180 B:B:W211 37.559416.04YesYes578
79B:B:C218 B:B:W211 35.23467.84NoYes558
80B:B:C218 G:G:Q18 35.29977.63NoNo059
81G:G:M21 G:G:Q18 35.02344.08NoNo019
82B:B:M217 G:G:M21 34.74652.89NoNo031
83B:B:M217 B:B:R219 32.94397.44NoYes235
84B:B:L210 B:B:R219 31.54293.64YesYes255
85B:B:L210 B:B:Q220 30.74657.99YesYes257
86B:B:D258 B:B:Q220 20.806711.75YesYes277
87B:B:D258 B:B:R22 10.414510.72YesYes276
88B:B:I18 G:G:L19 15.84671.43YesYes079
89B:B:L14 G:G:L19 12.70162.77NoYes089
90B:B:R283 B:B:V40 23.71197.85YesYes1293
91B:B:I37 B:B:R283 22.7465.01YesYes1229
92B:B:I37 B:B:T34 22.51093.04YesNo025
93B:B:L30 B:B:T34 21.84894.42NoNo055
94B:B:L261 B:B:L30 18.50954.15YesNo055
95B:B:V71 B:B:Y105 14.18553.79NoYes086
96B:B:C103 B:B:V71 11.38333.42NoNo088
97B:B:A73 B:B:C103 10.44543.61NoNo098
98B:B:L252 B:B:L261 16.82164.15NoYes075
99B:B:L252 B:B:Y264 16.48258.21NoYes075
100B:B:L318 B:B:S275 74.56596.01YesNo068
101B:B:S275 B:B:T274 74.39983.2NoNo088
102R:R:H656 R:R:I604 62.84385.3YesYes389
103R:R:I604 R:R:W649 48.62625.87YesYes399
104R:R:W649 R:R:W680 43.959814.06YesYes398
105R:R:W680 R:R:Y641 28.8818.68YesYes087
106R:R:C687 R:R:Y641 27.54314.03NoYes087
107R:R:C687 R:R:H640 27.36245.9NoYes089
108R:R:H640 R:R:L706 12.43157.71YesNo099
109R:R:I549 R:R:W705 19.80543.52YesYes489
110R:R:F716 R:R:H640 13.73453.39YesYes499
111R:R:F716 R:R:W705 36.55788.02YesYes499
112R:R:S645 R:R:W680 15.15287.41NoYes088
113R:R:P683 R:R:S645 14.54523.56YesNo088
114R:R:L644 R:R:P683 13.96743.28YesYes098
115R:R:F716 R:R:L644 13.16184.87YesYes499
116R:R:I604 R:R:V652 16.5517.68YesYes398
117R:R:M678 R:R:V652 32.20854.56NoYes078
118R:R:L651 R:R:M678 30.94664.24YesNo097
119R:R:L651 R:R:V723 29.30394.47YesNo098
120R:R:F647 R:R:V723 28.90027.87YesNo098
121R:R:F647 R:R:F716 26.11243.22YesYes099
122R:R:H656 R:R:Y675 16.34758.71YesYes388
123R:R:V652 R:R:Y675 16.14258.83YesYes388
124R:R:I549 R:R:N546 17.54432.83YesNo089
125R:R:F643 R:R:F716 14.09325.36YesYes489
126R:R:A816 R:R:L591 10.65063.15NoYes088
127R:R:L639 R:R:W705 15.49583.42YesYes099
128R:R:F643 R:R:L639 12.24794.87YesYes089
129R:R:L639 R:R:S622 25.73763YesNo098
130R:R:C704 R:R:S622 17.82443.44YesNo098
131B:B:R314 B:B:T274 74.3425.17YesNo088
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7EPT
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRD1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3
Date 2022-05-11
D.O.I. 10.1038/s41586-022-04619-y
Net Summary
Imin 3.2
Number of Linked Nodes 830
Number of Links 965
Number of Hubs 149
Number of Links mediated by Hubs 551
Number of Communities 27
Number of Nodes involved in Communities 206
Number of Links involved in Communities 280
Path Summary
Number Of Nodes in MetaPath 132
Number Of Links MetaPath 131
Number of Shortest Paths 759022
Length Of Smallest Path 3
Average Path Length 31.4431
Length of Longest Path 73
Minimum Path Strength 1.2
Average Path Strength 6.63299
Maximum Path Strength 23.76
Minimum Path Correlation 0.7
Average Path Correlation 0.976303
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.63158
Average % Of Corr. Nodes 50.7396
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.4586
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cell surface receptor signaling pathway   • nucleus   • membrane-enclosed lumen   • intracellular organelle lumen   • nuclear speck   • nuclear body   • nucleoplasm   • organelle lumen   • nuclear lumen
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7EPT_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG ASGIFETKF 
QVDKVNFHM FDVGAQRDE RRKWIQCFN DVTAIIFVV ANRLQAALK 
LFDSIWNNK WLRDTSVIL FLNKQDLLA EKVLAGKSK IEDYFPEFA 
RYTTPEDAT PEPGEDPRV TRAKYFIRD EFLRISTAS GDGRHYCYP 
HFTCAVDTE NIRRVFNDC RDIIQRMHL RQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7EPT_Chain_B
QSELDQLRQ EAEQLKNQI RDARKACAD ATLSQITNN IDPVGRIQM 
RTRRTLRGH LAKIYAMHW GTDSRLLVS ASQDGKLII WDSYTTNKV 
HAIPLRSSW VMTCAYAPS GNYVACGGL DNICSIYNL KTREGNVRV 
SRELAGHTG YLSCCRFLD DNQIVTSSG DTTCALWDI ETGQQTTTF 
TGHTGDVMS LSLAPDTRL FVSGACDAS AKLWDVREG MCRQTFTGH 
ESDINAICF FPNGNAFAT GSDDATCRL FDLRADQEL MTYSHDNII 
CGITSVSFS KSGRLLLAG YDDFNCNVW DALKADRAG VLAGHDNRV 
SCLGVTDDG MAVATGSWD SFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7EPT_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ6QNK2
Sequence
>7EPT_Chain_R
TNFAILMQV VPLELARGH QVALSSISY VGCSLSVLC LVATLVTFA 
VLSSVSTIR NQRYHIHAN LSFAVLVAQ VLLLISFRL EPGTTPCQV 
MAVLLHYFF LSAFAWMLV EGLHLYSMV IKVFGSEDS KHRYYYGMG 
WGFPLLICI ISLSFAMDS YGTSNNCWL SLASGAIWA FVAPALFVI 
VVNIGILIA VTRVISQIS AFKLTAKAV AVLLPILGT SWVFGVLAV 
NGCAVVFQY MFATLNSLQ GLFIFLFHC LLNSEVRAA FKHKTKVWS 
LT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IV2B2AdhesionAdhesionADGRD1Homo sapiens5α-DHT-chim(NtGi1-Gs)/β1/γ23.532025-02-12doi.org/10.1016/j.cell.2025.01.006
9IV2 (No Gprot) B2AdhesionAdhesionADGRD1Homo sapiens5α-DHT-3.532025-02-12doi.org/10.1016/j.cell.2025.01.006
9IV1B2AdhesionAdhesionADGRD1Homo sapiens5α-DHT-chim(NtGi1-Gs)/β1/γ22.982025-02-12doi.org/10.1016/j.cell.2025.01.006
9IV1 (No Gprot) B2AdhesionAdhesionADGRD1Homo sapiens5α-DHT-2.982025-02-12doi.org/10.1016/j.cell.2025.01.006
8X9UB2AdhesionAdhesionADGRD1Homo sapiensMetenolone-chim(NtGi1-Gs)/β1/γ22.882025-02-12doi.org/10.1016/j.cell.2025.01.006
8X9U (No Gprot) B2AdhesionAdhesionADGRD1Homo sapiensMetenolone-2.882025-02-12doi.org/10.1016/j.cell.2025.01.006
8X9TB2AdhesionAdhesionADGRD1Homo sapiensAP503-chim(NtGi1-Gs)/β1/γ22.752025-02-12doi.org/10.1016/j.cell.2025.01.006
8X9T (No Gprot) B2AdhesionAdhesionADGRD1Homo sapiensAP503-2.752025-02-12doi.org/10.1016/j.cell.2025.01.006
8X9SB2AdhesionAdhesionADGRD1Homo sapiens5α-DHT-chim(NtGi1-Gs)/β1/γ23.492025-02-12doi.org/10.1016/j.cell.2025.01.006
8X9S (No Gprot) B2AdhesionAdhesionADGRD1Homo sapiens5α-DHT-3.492025-02-12doi.org/10.1016/j.cell.2025.01.006
7EPTB2AdhesionAdhesionADGRD1Homo sapiens--Gs/β1/γ232022-05-1110.1038/s41586-022-04619-y
7EPT (No Gprot) B2AdhesionAdhesionADGRD1Homo sapiens--32022-05-1110.1038/s41586-022-04619-y
7WU2B2AdhesionAdhesionADGRD1Homo sapiens--Gs/β1/γ12.82022-04-2710.1038/s41586-022-04580-w
7WU2 (No Gprot) B2AdhesionAdhesionADGRD1Homo sapiens--2.82022-04-2710.1038/s41586-022-04580-w




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