Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 6.31254174
2A:A:Y37 8.8254184
3A:A:R42 7.27409
4A:A:F219 6.814508
5A:A:F222 11.07254197
6A:A:Q227 7.38419
7A:A:K233 6.09333619
8A:A:W234 6.092519
9A:A:I245 4.5925407
10A:A:L270 4.585406
11A:A:F273 6.94209
12A:A:W277 11.024206
13A:A:W281 13.2675415
14A:A:L282 3.1325409
15A:A:F312 4.33754148
16A:A:Y318 6.07754146
17A:A:R333 6.5405
18A:A:F340 7.6765147
19A:A:R342 6.61754114
20A:A:E344 6.23754145
21A:A:F345 7.7525408
22A:A:Y360 7.9925408
23A:A:F363 5.55754115
24A:A:T364 6.4454219
25A:A:C365 3.2525408
26A:A:D368 6.444219
27A:A:R373 6.19754135
28A:A:F376 6.1785138
29A:A:Y391 6.954534
30A:A:L393 4.796508
31A:A:L394 4.3375408
32B:B:L7 3.2175408
33B:B:I18 4.4425427
34B:B:R22 5.008526
35B:B:I37 5.62754122
36B:B:V40 4.108336123
37B:B:R52 6.91407
38B:B:H54 10.01599
39B:B:L55 5.83754186
40B:B:Y59 5.9775418
41B:B:W63 8.1365237
42B:B:D76 6.0545189
43B:B:W82 9.65857799
44B:B:D83 7.7754178
45B:B:K89 5.5525499
46B:B:I93 5.405407
47B:B:L95 5.835168
48B:B:W99 8.40167609
49B:B:M101 6.715419
50B:B:Y105 4.378506
51B:B:Y111 7.6375404
52B:B:C114 5.814168
53B:B:Y124 6.7245166
54B:B:H142 8.095419
55B:B:Y145 6.21167618
56B:B:F151 4.42333619
57B:B:I157 5.69417
58B:B:T159 5.058519
59B:B:S160 5.5425456
60B:B:D163 6.64519
61B:B:C166 4.0475458
62B:B:L168 4.285406
63B:B:W169 7.28667618
64B:B:F180 8.086557
65B:B:T181 2.7925412
66B:B:H183 7.23659
67B:B:D186 6.73419
68B:B:V187 5.0875459
69B:B:S201 4.6075459
70B:B:K209 9.8475456
71B:B:L210 6.0225425
72B:B:W211 9.07333658
73B:B:D212 8.4325429
74B:B:R219 7.7975425
75B:B:Q220 7.678527
76B:B:H225 6.77571729
77B:B:I232 5.095428
78B:B:F235 7.165676
79B:B:N237 7.275475
80B:B:F241 9.014526
81B:B:T243 6.625428
82B:B:D247 8.044529
83B:B:R251 10.712528
84B:B:F253 6.98333626
85B:B:D258 9.5975427
86B:B:L261 5.9075405
87B:B:Y264 8.026585
88B:B:F278 6.1975407
89B:B:R283 8.4445129
90B:B:Y289 6.36286787
91B:B:D298 8.36254129
92B:B:R304 7.2175405
93B:B:H311 7.044569
94B:B:R314 11.632518
95B:B:L318 5.1475406
96B:B:M325 5.30254105
97B:B:W332 11.9683619
98B:B:D333 6.902569
99B:B:F335 6.7425464
100B:B:K337 6.16566
101B:B:W339 9.42569
102G:G:L19 2.8409
103G:G:E22 4.7525429
104G:G:R27 5.81428
105G:G:D48 6.6075409
106G:G:E58 4.3754105
107G:G:P60 8.25754109
108G:G:F61 5.541676108
109R:R:I549 5.56448
110R:R:L591 2.88408
111R:R:R601 10.3654158
112R:R:Y602 8.493336158
113R:R:I604 6.42439
114R:R:F623 7.965406
115R:R:L639 3.86409
116R:R:H640 5.75167649
117R:R:Y641 5.605407
118R:R:F643 6.465448
119R:R:L644 5.715449
120R:R:F647 7.592509
121R:R:W649 8.69857739
122R:R:L651 3.615409
123R:R:V652 7.1075438
124R:R:E653 9.165439
125R:R:H656 6.734538
126R:R:M660 10.465438
127R:R:I662 5.37408
128R:R:F665 5.79508
129R:R:Y675 8.2438
130R:R:Y676 6.93538
131R:R:W680 7.706538
132R:R:P683 3.1525408
133R:R:Y698 4.056509
134R:R:N703 5.15447
135R:R:C704 4.73754279
136R:R:W705 6.475649
137R:R:W714 4.91408
138R:R:F716 4.78429749
139R:R:I728 2.6825405
140R:R:L765 4.845409
141R:R:I768 7.77438
142R:R:W773 10.454549
143R:R:Q788 4.854258
144R:R:Y789 5.8125409
145R:R:F791 7.112549
146R:R:F801 3.3525408
147R:R:F803 5.9165269
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:N23 B:B:N88 10.30110.9NoNo077
2A:A:N23 B:B:K89 10.68944.2NoYes079
3B:B:D76 B:B:S74 11.089410.31YesNo099
4B:B:H54 B:B:S74 11.08469.76YesNo099
5A:A:R42 A:A:Y37 11.232918.52YesYes094
6A:A:F219 A:A:H41 17.49464.53YesNo086
7A:A:H41 A:A:I383 21.16843.98NoNo068
8A:A:H387 A:A:I383 21.73416.63NoNo088
9A:A:H387 A:A:M386 97.30753.94NoNo083
10A:A:M386 A:A:Q390 97.36425.44NoNo034
11A:A:Q390 R:R:R601 97.42045.84NoYes048
12R:R:R601 R:R:Y602 97.45215.43YesYes1588
13R:R:I597 R:R:Y602 98.0049.67NoYes088
14R:R:A816 R:R:I597 98.0543.25NoNo088
15R:R:A816 R:R:V594 99.50985.09NoNo088
16B:B:D312 R:R:V594 99.54074.38NoNo058
17B:B:D312 B:B:D333 99.57113.99NoYes059
18B:B:D333 B:B:H311 99.45035.04YesYes699
19B:B:H311 B:B:T329 98.65446.85YesNo098
20B:B:L318 B:B:T329 1004.42YesNo068
21B:B:L286 B:B:L318 38.63964.15NoYes076
22B:B:L286 B:B:V296 38.54024.47NoNo075
23B:B:L284 B:B:V296 38.35064.47NoNo055
24B:B:L284 B:B:V40 38.27642.98NoYes053
25B:B:V40 G:G:L51 31.64022.98YesNo036
26G:G:D48 G:G:L51 31.39834.07YesNo096
27G:G:D48 G:G:P49 31.24613.22YesNo097
28B:B:M325 G:G:P49 31.20156.71YesNo057
29B:B:M325 G:G:P60 14.89696.71YesYes1059
30B:B:Y85 G:G:P60 15.069811.13NoYes1049
31B:B:R68 B:B:Y85 30.55421.61NoNo054
32B:B:D83 B:B:R68 30.129511.91YesNo085
33B:B:M325 G:G:F61 16.01693.73YesYes1058
34B:B:Y85 G:G:F61 15.70556.19NoYes1048
35A:A:F219 A:A:L43 16.30026.09YesNo087
36A:A:I245 A:A:L43 15.99995.71YesNo077
37B:B:H142 B:B:T159 41.9165.48YesYes199
38B:B:C149 B:B:T159 35.99353.38NoYes189
39B:B:C149 B:B:T102 36.10438.45NoNo088
40B:B:C148 B:B:T102 35.99173.38NoNo068
41B:B:C148 B:B:R150 35.89566.96NoNo066
42B:B:H62 B:B:R150 17.29610.16NoNo066
43B:B:H62 B:B:Y105 17.60873.27NoYes066
44B:B:L69 B:B:Y105 28.59824.69NoYes056
45B:B:D83 B:B:L69 28.93565.43YesNo085
46B:B:H142 B:B:S161 40.113716.74YesNo199
47B:B:G162 B:B:S161 41.79153.71NoNo199
48B:B:G162 B:B:Y145 41.61385.79NoYes198
49A:A:W234 B:B:Y145 26.24294.82YesYes198
50A:A:R231 A:A:W234 26.53796NoYes099
51A:A:L272 A:A:R231 26.01967.29NoNo089
52B:B:R314 B:B:W332 72.838821.99YesYes189
53B:B:W332 B:B:Y59 59.54245.79YesYes198
54B:B:M101 B:B:Y145 55.28577.18YesYes198
55B:B:M101 B:B:Y59 55.59289.58YesYes198
56A:A:F290 A:A:I245 13.57873.77NoYes097
57A:A:F246 A:A:L272 25.75487.31NoNo098
58A:A:F246 A:A:L289 25.49163.65NoNo099
59A:A:F345 A:A:L289 25.227812.18YesNo089
60A:A:E344 A:A:F340 14.78468.16YesYes1457
61A:A:E344 A:A:L270 16.23483.98YesYes056
62A:A:F345 A:A:L270 19.41546.09YesYes086
63A:A:H387 R:R:M660 91.306517.07NoYes088
64A:A:Y391 R:R:M660 12.158110.78YesYes348
65R:R:H656 R:R:M660 78.86227.88YesYes388
66B:B:L192 B:B:R150 44.69446.07NoNo056
67B:B:L152 B:B:L192 44.42094.15NoNo035
68B:B:L152 B:B:Q156 43.87237.99NoNo035
69B:B:L168 B:B:Q156 43.59725.32YesNo065
70B:B:L168 B:B:T178 42.76884.42YesNo064
71B:B:F180 B:B:T178 42.49163.89YesNo074
72B:B:F180 B:B:W211 39.553216.04YesYes578
73B:B:C218 B:B:W211 37.07947.84NoYes558
74B:B:C218 G:G:Q18 37.14497.63NoNo059
75G:G:M21 G:G:Q18 36.85124.08NoNo019
76B:B:M217 G:G:M21 36.55712.89NoNo031
77B:B:M217 B:B:R219 34.31987.44NoYes235
78B:B:L210 B:B:R219 32.53043.64YesYes255
79B:B:L210 B:B:Q220 31.70567.99YesYes257
80B:B:D258 B:B:Q220 21.431911.75YesYes277
81B:B:D258 B:B:R22 11.064510.72YesYes276
82B:B:I18 G:G:L19 15.49761.43YesYes079
83B:B:L14 G:G:L19 13.49162.77NoYes089
84B:B:E10 B:B:L14 10.1387.95NoNo088
85B:B:R283 B:B:V40 24.84617.85YesYes1293
86B:B:I37 B:B:R283 23.83495.01YesYes1229
87B:B:I37 B:B:T34 23.58993.04YesNo025
88B:B:L30 B:B:T34 22.89654.42NoNo055
89B:B:L261 B:B:L30 19.39864.15YesNo055
90B:B:V71 B:B:Y105 16.10553.79NoYes086
91B:B:C103 B:B:V71 13.12583.42NoNo088
92B:B:A73 B:B:C103 12.12853.61NoNo098
93B:B:A73 B:B:V100 11.62913.39NoNo099
94B:B:L95 B:B:V100 11.12914.47YesNo089
95B:B:L252 B:B:L261 17.63034.15NoYes075
96B:B:L252 B:B:Y264 17.27518.21NoYes075
97B:B:L318 B:B:S275 73.51856.01YesNo068
98B:B:R314 B:B:T274 73.26075.17YesNo088
99R:R:H656 R:R:I604 63.67715.3YesYes389
100R:R:I604 R:R:W649 49.36175.87YesYes399
101R:R:W649 R:R:W680 44.633614.06YesYes398
102R:R:W680 R:R:Y641 29.33468.68YesYes087
103R:R:C687 R:R:Y641 27.9864.03NoYes087
104R:R:C687 R:R:H640 27.80445.9NoYes089
105R:R:H640 R:R:L706 12.65227.71YesNo099
106R:R:I549 R:R:W705 20.15123.52YesYes489
107R:R:F716 R:R:H640 13.98383.39YesYes499
108R:R:F716 R:R:W705 37.1658.02YesYes499
109R:R:S645 R:R:W680 15.38767.41NoYes088
110R:R:P683 R:R:S645 14.77333.56YesNo088
111R:R:L644 R:R:P683 14.19073.28YesYes098
112R:R:F716 R:R:L644 13.37654.87YesYes499
113R:R:I604 R:R:V652 16.80027.68YesYes398
114R:R:M678 R:R:V652 32.67284.56NoYes078
115R:R:L651 R:R:M678 31.39474.24YesNo097
116R:R:L651 R:R:V723 29.73284.47YesNo098
117R:R:F647 R:R:V723 29.32487.87YesNo098
118R:R:F647 R:R:F716 26.52883.22YesYes099
119R:R:H656 R:R:Y675 16.56428.71YesYes388
120R:R:V652 R:R:Y675 16.36698.83YesYes388
121R:R:I549 R:R:N546 17.85372.83YesNo089
122R:R:F643 R:R:F716 14.3045.36YesYes489
123R:R:A816 R:R:L591 10.94423.15NoYes088
124R:R:L639 R:R:W705 15.73123.42YesYes099
125R:R:F643 R:R:L639 12.42734.87YesYes089
126R:R:L639 R:R:S622 26.12143YesNo098
127R:R:C704 R:R:S622 18.09043.44YesNo098
128R:R:C632 R:R:C704 10.05557.28NoYes2799
129B:B:S275 B:B:T274 73.32233.2NoNo088
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7EPT
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRD1
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3
Date 2022-05-11
D.O.I. 10.1038/s41586-022-04619-y
Net Summary
Imin 3.2
Number of Linked Nodes 831
Number of Links 965
Number of Hubs 147
Number of Links mediated by Hubs 545
Number of Communities 28
Number of Nodes involved in Communities 206
Number of Links involved in Communities 278
Path Summary
Number Of Nodes in MetaPath 130
Number Of Links MetaPath 129
Number of Shortest Paths 733510
Length Of Smallest Path 3
Average Path Length 31.3894
Length of Longest Path 73
Minimum Path Strength 1.2
Average Path Strength 6.56577
Maximum Path Strength 23.76
Minimum Path Correlation 0.7
Average Path Correlation 0.976096
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.63158
Average % Of Corr. Nodes 50.5951
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.6812
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7EPT_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG ASGIFETKF 
QVDKVNFHM FDVGAQRDE RRKWIQCFN DVTAIIFVV ANRLQAALK 
LFDSIWNNK WLRDTSVIL FLNKQDLLA EKVLAGKSK IEDYFPEFA 
RYTTPEDAT PEPGEDPRV TRAKYFIRD EFLRISTAS GDGRHYCYP 
HFTCAVDTE NIRRVFNDC RDIIQRMHL RQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7EPT_Chain_B
QSELDQLRQ EAEQLKNQI RDARKACAD ATLSQITNN IDPVGRIQM 
RTRRTLRGH LAKIYAMHW GTDSRLLVS ASQDGKLII WDSYTTNKV 
HAIPLRSSW VMTCAYAPS GNYVACGGL DNICSIYNL KTREGNVRV 
SRELAGHTG YLSCCRFLD DNQIVTSSG DTTCALWDI ETGQQTTTF 
TGHTGDVMS LSLAPDTRL FVSGACDAS AKLWDVREG MCRQTFTGH 
ESDINAICF FPNGNAFAT GSDDATCRL FDLRADQEL MTYSHDNII 
CGITSVSFS KSGRLLLAG YDDFNCNVW DALKADRAG VLAGHDNRV 
SCLGVTDDG MAVATGSWD SFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7EPT_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ6QNK2
Sequence
>7EPT_Chain_R
TNFAILMQV VPLELARGH QVALSSISY VGCSLSVLC LVATLVTFA 
VLSSVSTIR NQRYHIHAN LSFAVLVAQ VLLLISFRL EPGTTPCQV 
MAVLLHYFF LSAFAWMLV EGLHLYSMV IKVFGSEDS KHRYYYGMG 
WGFPLLICI ISLSFAMDS YGTSNNCWL SLASGAIWA FVAPALFVI 
VVNIGILIA VTRVISQIS AFKLTAKAV AVLLPILGT SWVFGVLAV 
NGCAVVFQY MFATLNSLQ GLFIFLFHC LLNSEVRAA FKHKTKVWS 
LT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EPTB2AdhesionAdhesionADGRD1Homo sapiens--Gs/&β;1/&γ;232022-05-1110.1038/s41586-022-04619-y
7WU2B2AdhesionAdhesionADGRD1Homo sapiens--Gs/&β;1/&γ;12.82022-04-2710.1038/s41586-022-04580-w




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EPT.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.