psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A548	R:R:N546	3.13	Yes	No	1	9	9
2	R:R:L566	R:R:N546	10.98	No	No	1	9	9
3	R:R:F547	R:R:L550	10.96	Yes	No	1	9	9
4	R:R:F547	R:R:S570	3.96	Yes	No	0	9	7
5	R:R:F547	R:R:Q616	7.03	Yes	Yes	1	9	8
6	R:R:F547	R:R:L619	3.65	Yes	No	0	9	9
7	R:R:F547	R:R:F643	5.36	Yes	Yes	1	9	8
8	R:R:F547	R:R:N795	13.29	Yes	Yes	1	9	9
9	R:R:A548	R:R:L566	3.15	Yes	No	1	9	9
10	R:R:A548	R:R:Q788	4.55	Yes	Yes	0	9	8
11	R:R:I549	R:R:W705	11.74	No	Yes	0	8	9
12	R:R:F643	R:R:L550	7.31	Yes	No	1	8	9
13	R:R:L550	R:R:W705	9.11	No	Yes	1	9	9
14	R:R:F716	R:R:M551	3.73	Yes	Yes	0	9	9
15	R:R:A720	R:R:M551	3.22	No	Yes	0	9	9
16	R:R:M551	R:R:W773	5.82	Yes	Yes	0	9	9
17	R:R:G776	R:R:M551	3.49	No	Yes	0	9	9
18	R:R:M551	R:R:V777	3.04	Yes	No	0	9	7
19	R:R:Q552	R:R:Q788	12.8	No	Yes	0	9	8
20	R:R:I713	R:R:V553	3.07	Yes	No	1	8	8
21	R:R:V553	R:R:W714	9.81	No	Yes	1	8	8
22	R:R:V553	R:R:V717	4.81	No	No	1	8	8
23	R:R:P555	R:R:V554	3.53	No	No	0	6	8
24	R:R:V554	R:R:V780	4.81	No	No	0	8	7
25	R:R:L708	R:R:P555	9.85	No	No	0	7	6
26	R:R:H562	R:R:L558	21.86	Yes	No	5	7	5
27	R:R:L558	R:R:V785	2.98	No	No	5	5	5
28	R:R:H562	R:R:V785	4.15	Yes	No	5	7	5
29	R:R:H562	R:R:Y789	18.51	Yes	No	0	7	9
30	R:R:Q563	R:R:S567	5.78	No	No	0	4	7
31	R:R:A565	R:R:Y789	4	No	No	0	6	9
32	R:R:A792	R:R:L566	3.15	No	No	0	8	9
33	R:R:F623	R:R:Y571	5.16	No	No	0	6	7
34	R:R:G573	R:R:S796	3.71	No	No	6	9	9
35	R:R:G573	R:R:L797	5.13	No	Yes	6	9	7
36	R:R:C574	R:R:Q616	7.63	No	Yes	0	8	8
37	R:R:C574	R:R:L620	3.17	No	No	0	8	8
38	R:R:L576	R:R:S575	4.5	No	No	0	5	7
39	R:R:L576	R:R:L579	5.54	No	No	0	5	4
40	R:R:Q616	R:R:S577	7.22	Yes	No	0	8	9
41	R:R:G799	R:R:S577	3.71	No	No	0	8	9
42	R:R:V578	R:R:V617	8.02	No	No	0	7	5
43	R:R:C580	R:R:L800	3.17	No	No	0	7	6
44	R:R:C580	R:R:F803	5.59	No	Yes	0	7	9
45	R:R:L581	R:R:T584	7.37	Yes	Yes	3	9	9
46	R:R:L581	R:R:S609	3	Yes	No	3	9	8
47	R:R:L581	R:R:V612	2.98	Yes	No	0	9	8
48	R:R:L581	R:R:L613	4.15	Yes	Yes	0	9	8
49	R:R:G799	R:R:L581	5.13	No	Yes	0	8	9
50	R:R:S609	R:R:T584	3.2	No	Yes	3	8	9
51	R:R:F803	R:R:T584	3.89	Yes	Yes	3	9	9
52	R:R:C807	R:R:T584	6.76	No	Yes	3	8	9
53	R:R:F588	R:R:T587	3.89	No	No	0	7	8
54	R:R:L591	R:R:T587	2.95	Yes	No	0	8	8
55	R:R:C807	R:R:T587	3.38	No	No	0	8	8
56	R:R:L591	R:R:V590	2.98	Yes	No	0	8	4
57	R:R:A816	R:R:L591	3.15	No	Yes	0	8	8
58	R:R:F817	R:R:L591	8.53	No	Yes	0	7	8
59	R:R:K820	R:R:L591	4.23	Yes	Yes	0	8	8
60	R:R:K820	R:R:S593	4.59	Yes	No	0	8	8
61	R:R:I597	R:R:V594	3.07	Yes	No	0	8	8
62	R:R:H819	R:R:V594	4.15	No	No	0	8	8
63	R:R:E812	R:R:T596	5.64	Yes	No	0	8	9
64	R:R:I597	R:R:V813	3.07	Yes	No	0	8	9
65	R:R:A816	R:R:I597	3.25	No	Yes	0	8	8
66	R:R:N599	R:R:R601	7.23	No	No	0	8	8
67	R:R:H656	R:R:Q600	11.13	Yes	No	2	8	8
68	R:R:H672	R:R:Q600	7.42	No	No	0	7	8
69	R:R:Q600	R:R:Y675	6.76	No	Yes	2	8	8
70	R:R:R601	R:R:Y602	24.69	No	No	0	8	8
71	R:R:N810	R:R:Y602	4.65	No	No	7	9	8
72	R:R:E812	R:R:Y602	3.37	Yes	No	7	8	8
73	R:R:H603	R:R:H672	3.58	No	No	0	8	7
74	R:R:H603	R:R:Y676	5.44	No	No	0	8	8
75	R:R:I604	R:R:W649	7.05	Yes	Yes	2	9	9
76	R:R:I604	R:R:V652	6.14	Yes	Yes	2	9	8
77	R:R:E653	R:R:I604	8.2	No	Yes	2	9	9
78	R:R:H656	R:R:I604	5.3	Yes	Yes	2	8	9
79	R:R:I604	R:R:Y675	6.04	Yes	Yes	2	9	8
80	R:R:E653	R:R:H605	12.31	No	No	2	9	9
81	R:R:H605	R:R:I768	5.3	No	Yes	2	9	8
82	R:R:H605	R:R:H806	10.75	No	Yes	2	9	9
83	R:R:N607	R:R:W649	18.08	No	Yes	2	9	9
84	R:R:N607	R:R:Y676	6.98	No	No	2	9	8
85	R:R:N607	R:R:W680	3.39	No	Yes	2	9	8
86	R:R:L608	R:R:V612	2.98	No	No	0	9	8
87	R:R:L608	R:R:W649	4.56	No	Yes	0	9	9
88	R:R:F610	R:R:V614	6.55	No	No	0	4	6
89	R:R:A611	R:R:W680	3.89	No	Yes	0	8	8
90	R:R:Q616	R:R:V612	4.3	Yes	No	0	8	8
91	R:R:F642	R:R:V614	7.87	No	No	0	8	6
92	R:R:A615	R:R:F643	8.32	No	Yes	0	9	8
93	R:R:F643	R:R:Q616	4.68	Yes	Yes	1	8	8
94	R:R:L618	R:R:L639	6.92	No	No	0	7	9
95	R:R:F623	R:R:L619	12.18	No	No	0	6	9
96	R:R:L619	R:R:L639	4.15	No	No	0	9	9
97	R:R:M635	R:R:S622	6.13	No	No	0	6	8
98	R:R:L639	R:R:S622	3	No	No	0	9	8
99	R:R:C704	R:R:S622	3.44	No	No	0	9	8
100	R:R:L625	R:R:P631	3.28	No	No	0	4	6
101	R:R:E626	R:R:P627	7.86	No	No	0	2	5
102	R:R:P631	R:R:T629	10.49	No	No	0	6	8
103	R:R:P631	R:R:T630	3.5	No	No	0	6	3
104	R:R:C632	R:R:C704	7.28	No	No	0	9	9
105	R:R:V637	R:R:Y698	17.66	No	No	0	4	9
106	R:R:C687	R:R:H640	8.85	No	No	0	8	9
107	R:R:H640	R:R:S690	8.37	No	No	0	9	8
108	R:R:H640	R:R:Y698	10.89	No	No	0	9	9
109	R:R:F642	R:R:Y641	7.22	No	Yes	0	8	7
110	R:R:W680	R:R:Y641	5.79	Yes	Yes	0	8	7
111	R:R:L684	R:R:Y641	9.38	No	Yes	0	5	7
112	R:R:C687	R:R:Y641	5.38	No	Yes	0	8	7
113	R:R:F643	R:R:F716	3.22	Yes	Yes	0	8	9
114	R:R:L644	R:R:P683	3.28	No	Yes	0	9	8
115	R:R:I686	R:R:L644	7.14	No	No	0	7	9
116	R:R:L644	R:R:P719	3.28	No	No	0	9	9
117	R:R:S645	R:R:W680	8.65	No	Yes	0	8	8
118	R:R:P683	R:R:S645	3.56	Yes	No	0	8	8
119	R:R:F647	R:R:M650	3.73	Yes	No	1	9	9
120	R:R:F647	R:R:F716	4.29	Yes	Yes	0	9	9
121	R:R:A720	R:R:F647	6.93	No	Yes	0	9	9
122	R:R:F647	R:R:V723	6.55	Yes	No	0	9	8
123	R:R:F647	R:R:W773	21.05	Yes	Yes	1	9	9
124	R:R:A648	R:R:P683	3.74	No	Yes	0	7	8
125	R:R:V652	R:R:W649	7.36	Yes	Yes	2	8	9
126	R:R:W649	R:R:Y676	3.86	Yes	No	2	9	8
127	R:R:G679	R:R:W649	5.63	No	Yes	0	9	9
128	R:R:W649	R:R:W680	16.87	Yes	Yes	2	9	8
129	R:R:M650	R:R:W773	4.65	No	Yes	1	9	9
130	R:R:M650	R:R:Q798	5.44	No	No	1	9	9
131	R:R:L651	R:R:L655	4.15	Yes	No	0	9	7
132	R:R:L651	R:R:M678	5.65	Yes	No	0	9	7
133	R:R:L651	R:R:V723	4.47	Yes	No	0	9	8
134	R:R:L651	R:R:V726	2.98	Yes	No	0	9	8
135	R:R:V652	R:R:Y675	11.36	Yes	Yes	2	8	8
136	R:R:M678	R:R:V652	3.04	No	Yes	0	7	8
137	R:R:E653	R:R:I768	6.83	No	Yes	2	9	8
138	R:R:H656	R:R:S659	4.18	Yes	No	0	8	8
139	R:R:H656	R:R:M660	7.88	Yes	No	0	8	8
140	R:R:H656	R:R:Y675	11.98	Yes	Yes	2	8	8
141	R:R:I730	R:R:L657	4.28	No	Yes	0	8	9
142	R:R:L657	R:R:V734	5.96	Yes	No	0	9	9
143	R:R:L657	R:R:L765	5.54	Yes	No	0	9	9
144	R:R:I662	R:R:Y658	9.67	No	No	0	8	8
145	R:R:I730	R:R:Y658	3.63	No	No	0	8	8
146	R:R:M660	R:R:S667	3.07	No	No	0	8	8
147	R:R:V661	R:R:V734	3.21	No	No	0	9	9
148	R:R:E668	R:R:S667	4.31	No	No	0	8	8
149	R:R:D669	R:R:K671	11.06	No	No	0	6	8
150	R:R:R673	R:R:Y674	5.14	No	No	0	3	5
151	R:R:F682	R:R:M678	4.98	No	No	0	4	7
152	R:R:F682	R:R:L685	3.65	No	No	0	4	5
153	R:R:I686	R:R:S690	3.1	No	No	0	7	8
154	R:R:A715	R:R:S690	3.42	No	No	0	9	8
155	R:R:L691	R:R:M695	12.72	No	No	0	4	2
156	R:R:A694	R:R:S697	3.42	No	No	0	6	7
157	R:R:A712	R:R:S697	3.42	No	No	0	7	7
158	R:R:G699	R:R:T700	3.64	No	No	0	8	4
159	R:R:N702	R:R:S701	4.47	No	No	0	3	3
160	R:R:S701	R:R:S707	6.52	No	No	0	3	8
161	R:R:L706	R:R:W705	13.67	No	Yes	1	9	9
162	R:R:I713	R:R:W705	4.7	Yes	Yes	1	8	9
163	R:R:F716	R:R:W705	9.02	Yes	Yes	0	9	9
164	R:R:A712	R:R:L706	3.15	No	No	0	7	9
165	R:R:I713	R:R:L706	7.14	Yes	No	1	8	9
166	R:R:I713	R:R:L708	4.28	Yes	No	0	8	7
167	R:R:G711	R:R:W714	5.63	No	Yes	0	7	8
168	R:R:I713	R:R:W714	5.87	Yes	Yes	1	8	8
169	R:R:I713	R:R:V717	4.61	Yes	No	1	8	8
170	R:R:V717	R:R:W714	4.9	No	Yes	1	8	8
171	R:R:L721	R:R:V777	2.98	No	No	0	7	7
172	R:R:N727	R:R:V723	2.96	No	No	0	9	8
173	R:R:I724	R:R:V774	3.07	No	No	0	9	5
174	R:R:L769	R:R:N727	12.36	No	No	0	9	9
175	R:R:I728	R:R:T771	6.08	No	No	0	5	8
176	R:R:L731	R:R:T735	2.95	Yes	No	0	8	9
177	R:R:L731	R:R:V762	5.96	Yes	No	0	8	8
178	R:R:L731	R:R:L769	5.54	Yes	No	0	8	9
179	R:R:L731	R:R:T771	2.95	Yes	No	0	8	8
180	R:R:R736	R:R:S739	7.91	No	No	0	7	8
181	R:R:Q740	R:R:R736	8.18	No	No	0	8	7
182	R:R:Q740	R:R:V737	7.16	No	No	0	8	8
183	R:R:F755	R:R:S742	9.25	No	No	0	6	8
184	R:R:F755	R:R:T758	6.49	No	No	0	6	8
185	R:R:F805	R:R:V764	5.24	No	No	2	8	8
186	R:R:H806	R:R:V764	5.54	Yes	No	2	9	8
187	R:R:L766	R:R:T771	5.9	No	No	0	8	8
188	R:R:L766	R:R:S772	4.5	No	No	0	8	9
189	R:R:F801	R:R:P767	4.33	No	No	0	8	9
190	R:R:I802	R:R:P767	3.39	No	No	0	8	9
191	R:R:H806	R:R:I768	9.28	Yes	Yes	2	9	8
192	R:R:L794	R:R:S772	9.01	No	No	0	6	9
193	R:R:F791	R:R:W773	6.01	Yes	Yes	1	9	9
194	R:R:N795	R:R:W773	19.21	Yes	Yes	1	9	9
195	R:R:Q798	R:R:W773	5.48	No	Yes	1	9	9
196	R:R:F775	R:R:L778	3.65	Yes	No	4	8	7
197	R:R:F775	R:R:F787	6.43	Yes	No	4	8	7
198	R:R:F775	R:R:M790	12.44	Yes	No	4	8	5
199	R:R:F775	R:R:L794	4.87	Yes	No	4	8	6
200	R:R:F791	R:R:G776	6.02	Yes	No	0	9	9
201	R:R:F787	R:R:L778	19.49	No	No	4	7	7
202	R:R:A779	R:R:Q788	4.55	No	Yes	0	8	8
203	R:R:L794	R:R:M790	7.07	No	No	4	6	5
204	R:R:F791	R:R:N795	7.25	Yes	Yes	1	9	9
205	R:R:N795	R:R:Q798	3.96	Yes	No	1	9	9
206	R:R:L797	R:R:S796	4.5	Yes	No	6	7	9
207	R:R:L797	R:R:L800	4.15	Yes	No	0	7	6
208	R:R:F803	R:R:L804	4.87	Yes	No	0	9	8
209	R:R:C807	R:R:F803	5.59	No	Yes	3	8	9
210	R:R:F803	R:R:L808	15.83	Yes	No	0	9	7
211	R:R:F805	R:R:H806	3.39	No	Yes	2	8	9
212	R:R:E812	R:R:N810	10.52	Yes	No	7	8	9
213	R:R:N810	R:R:V813	2.96	No	No	0	9	9
214	R:R:E812	R:R:S811	4.31	Yes	No	0	8	8
215	R:R:K820	R:R:V823	4.55	Yes	No	0	8	7
216	R:R:K820	R:R:W824	4.64	Yes	No	0	8	7
217	R:R:L826	R:R:S825	6.01	No	No	0	8	8
218	R:R:D669	R:R:S670	2.94	No	No	0	6	7
219	R:R:A559	R:R:H562	2.93	No	Yes	0	3	7
220	R:R:I621	R:R:M635	2.92	No	No	0	4	6
221	R:R:Q563	R:R:V564	2.87	No	No	0	4	5
222	R:R:I802	R:R:L581	2.85	No	Yes	0	8	9
223	R:R:I768	R:R:L765	2.85	Yes	No	0	8	9
224	R:R:I549	R:R:N703	2.83	No	No	0	8	7
225	R:R:L625	R:R:M635	2.83	No	No	0	4	6
226	R:R:E626	R:R:T629	2.82	No	No	0	2	8
227	R:R:G770	R:R:W773	2.81	No	Yes	0	9	9
228	R:R:H672	R:R:S670	2.79	No	No	0	7	7
229	R:R:A548	R:R:F791	2.77	Yes	Yes	1	9	9
230	R:R:L576	R:R:L797	2.77	No	Yes	0	5	7
231	R:R:L585	R:R:L613	2.77	No	Yes	0	7	8
232	R:R:N702	R:R:N703	2.72	No	No	0	3	7
233	R:R:F722	R:R:V726	2.62	No	No	0	5	8
234	R:R:F817	R:R:T821	2.59	No	No	0	7	8
235	R:R:S567	R:R:Y571	2.54	No	No	0	7	7
236	R:R:K663	R:R:Y658	2.39	No	No	0	7	8
237	R:R:I724	R:R:W773	2.35	No	Yes	0	9	9
238	R:R:L691	R:R:Y698	2.34	No	No	0	4	9
239	R:R:G681	R:R:P683	2.03	No	Yes	0	9	8
240	R:R:C632	R:R:G699	1.96	No	No	0	9	8
241	R:R:A718	R:R:P719	1.87	No	No	0	7	9
242	R:R:G573	R:R:V572	1.84	No	No	0	9	5
243	R:R:A636	R:R:C704	1.81	No	No	0	9	9
244	R:R:A611	R:R:A646	1.79	No	No	0	8	7
245	R:R:G654	R:R:L657	1.71	No	Yes	0	9	9
246	R:R:G654	R:R:L769	1.71	No	No	0	9	9
247	R:R:A709	R:R:S707	1.71	No	No	0	2	8
248	R:R:S697	R:R:S710	1.63	No	No	0	7	4
249	R:R:A792	R:R:I569	1.62	No	No	0	8	9
250	R:R:S667	R:R:V664	1.62	No	No	0	8	9
251	R:R:A761	R:R:I738	1.62	No	No	0	9	9
252	R:R:A759	R:R:K756	1.61	No	No	0	6	6
253	R:R:S595	R:R:T596	1.6	No	No	0	9	9
254	R:R:V661	R:R:V737	1.6	No	No	0	9	8
255	R:R:S739	R:R:T758	1.6	No	No	0	8	8
256	R:R:T630	R:R:V634	1.59	No	No	0	3	4
257	R:R:T827	R:R:V823	1.59	No	No	0	8	7
258	R:R:I569	R:R:S568	1.55	No	No	0	9	5
259	R:R:I597	R:R:S592	1.55	Yes	No	0	8	8
260	R:R:I569	R:R:T793	1.52	No	No	0	9	5
261	R:R:L757	R:R:S742	1.5	No	No	0	8	8
262	R:R:L613	R:R:V578	1.49	Yes	No	0	8	7
263	R:R:L613	R:R:V582	1.49	Yes	No	0	8	4
264	R:R:I728	R:R:I732	1.47	No	No	0	5	4
265	R:R:Q788	R:R:V785	1.43	Yes	No	0	8	5
266	R:R:K822	R:R:L826	1.41	No	No	0	8	8
267	R:R:A583	R:R:F803	1.39	No	Yes	0	6	9
268	R:R:A606	R:R:F588	1.39	No	No	0	7	7
269	R:R:A694	R:R:F693	1.39	No	No	0	6	5
270	R:R:L618	R:R:L638	1.38	No	No	0	7	7
271	R:R:L808	R:R:L809	1.38	No	No	0	7	8
272	R:R:I741	R:R:Q740	1.37	No	No	0	8	8
273	R:R:R598	R:R:S592	1.32	No	No	0	7	8
274	R:R:R814	R:R:V813	1.31	No	No	0	9	9
275	R:R:F805	R:R:K760	1.24	No	No	0	8	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F547	7.375	6	1	9
2	R:R:A548	3.4	4	1	9
3	R:R:M551	3.86	5	0	9
4	R:R:H562	11.8625	4	5	7
5	R:R:L581	4.24667	6	3	9
6	R:R:T584	5.305	4	3	9
7	R:R:L591	4.368	5	0	8
8	R:R:I597	2.735	4	0	8
9	R:R:I604	6.546	5	2	9
10	R:R:L613	2.475	4	0	8
11	R:R:Q616	6.172	5	1	8
12	R:R:Y641	6.9425	4	0	7
13	R:R:F643	5.778	5	1	8
14	R:R:F647	8.51	5	1	9
15	R:R:W649	9.05857	7	2	9
16	R:R:L651	4.3125	4	0	9
17	R:R:V652	6.975	4	2	8
18	R:R:H656	8.094	5	2	8
19	R:R:L657	4.3725	4	0	9
20	R:R:Y675	9.035	4	2	8
21	R:R:W680	7.718	5	2	8
22	R:R:P683	3.1525	4	0	8
23	R:R:W705	9.648	5	1	9
24	R:R:I713	4.945	6	1	8
25	R:R:W714	6.5525	4	1	8
26	R:R:F716	5.065	4	0	9
27	R:R:L731	4.35	4	0	8
28	R:R:I768	6.065	4	2	8
29	R:R:W773	8.4225	8	1	9
30	R:R:F775	6.8475	4	4	8
31	R:R:Q788	5.8325	4	0	8
32	R:R:F791	5.5125	4	1	9
33	R:R:N795	10.9275	4	1	9
34	R:R:L797	4.1375	4	6	7
35	R:R:F803	6.19333	6	3	9
36	R:R:H806	7.24	4	2	9
37	R:R:E812	5.96	4	7	8
38	R:R:K820	4.5025	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A548	R:R:F791	34.3391	2.77	Yes	Yes	1	9	9
2	R:R:F791	R:R:N795	19.2522	7.25	Yes	Yes	1	9	9
3	R:R:F547	R:R:N795	33.2371	13.29	Yes	Yes	1	9	9
4	R:R:F547	R:R:L550	23.634	10.96	Yes	No	1	9	9
5	R:R:F547	R:R:Q616	55.428	7.03	Yes	Yes	1	9	8
6	R:R:F547	R:R:L619	42.0794	3.65	Yes	No	0	9	9
7	R:R:F791	R:R:W773	15.5067	6.01	Yes	Yes	1	9	9
8	R:R:F716	R:R:M551	12.5877	3.73	Yes	Yes	0	9	9
9	R:R:F716	R:R:W705	37.7894	9.02	Yes	Yes	0	9	9
10	R:R:I549	R:R:W705	21.489	11.74	No	Yes	0	8	9
11	R:R:F647	R:R:W773	25.3723	21.05	Yes	Yes	1	9	9
12	R:R:F647	R:R:F716	33.998	4.29	Yes	Yes	0	9	9
13	R:R:L550	R:R:W705	39.285	9.11	No	Yes	1	9	9
14	R:R:A548	R:R:Q788	19.6458	4.55	Yes	Yes	0	9	8
15	R:R:I713	R:R:W705	31.8006	4.7	Yes	Yes	1	8	9
16	R:R:I713	R:R:L708	14.4769	4.28	Yes	No	0	8	7
17	R:R:L708	R:R:P555	10.8757	9.85	No	No	0	7	6
18	R:R:Q788	R:R:V785	13.1453	1.43	Yes	No	0	8	5
19	R:R:A548	R:R:L566	11.1118	3.15	Yes	No	1	9	9
20	R:R:Q616	R:R:V612	100	4.3	Yes	No	0	8	8
21	R:R:L581	R:R:V612	83.5618	2.98	Yes	No	0	9	8
22	R:R:L581	R:R:T584	70.7773	7.37	Yes	Yes	3	9	9
23	R:R:F803	R:R:T584	22.7681	3.89	Yes	Yes	3	9	9
24	R:R:C580	R:R:F803	16.6415	5.59	No	Yes	0	7	9
25	R:R:C580	R:R:L800	14.8442	3.17	No	No	0	7	6
26	R:R:L797	R:R:L800	13.0338	4.15	Yes	No	0	7	6
27	R:R:C807	R:R:T584	46.9531	6.76	No	Yes	3	8	9
28	R:R:C807	R:R:T587	48.0813	3.38	No	No	0	8	8
29	R:R:L591	R:R:T587	43.3847	2.95	Yes	No	0	8	8
30	R:R:A816	R:R:L591	28.8554	3.15	No	Yes	0	8	8
31	R:R:A816	R:R:I597	27.1499	3.25	No	Yes	0	8	8
32	R:R:I597	R:R:V813	18.4257	3.07	Yes	No	0	8	9
33	R:R:N810	R:R:V813	14.8442	2.96	No	No	0	9	9
34	R:R:F647	R:R:V723	54.3063	6.55	Yes	No	0	9	8
35	R:R:L651	R:R:V723	26.1725	4.47	Yes	No	0	9	8
36	R:R:L651	R:R:M678	25.2017	5.65	Yes	No	0	9	7
37	R:R:M678	R:R:V652	25.3591	3.04	No	Yes	0	7	8
38	R:R:H656	R:R:I604	15.0344	5.3	Yes	Yes	2	8	9
39	R:R:L608	R:R:V612	75.9528	2.98	No	No	0	9	8
40	R:R:L608	R:R:W649	75.3427	4.56	No	Yes	0	9	9
41	R:R:I604	R:R:W649	37.4549	7.05	Yes	Yes	2	9	9
42	R:R:E653	R:R:I604	35.0476	8.2	No	Yes	2	9	9
43	R:R:E653	R:R:I768	23.7717	6.83	No	Yes	2	9	8
44	R:R:N727	R:R:V723	40.4657	2.96	No	No	0	9	8
45	R:R:L769	R:R:N727	39.1604	12.36	No	No	0	9	9
46	R:R:G654	R:R:L769	20.3345	1.71	No	No	0	9	9
47	R:R:G654	R:R:L657	19.8426	1.71	No	Yes	0	9	9
48	R:R:L657	R:R:L765	17.0548	5.54	Yes	No	0	9	9
49	R:R:I768	R:R:L765	17.3959	2.85	Yes	No	0	8	9
50	R:R:W649	R:R:W680	41.7252	16.87	Yes	Yes	2	9	8
51	R:R:W680	R:R:Y641	23.6733	5.79	Yes	Yes	0	8	7
52	R:R:L619	R:R:L639	32.345	4.15	No	No	0	9	9
53	R:R:L639	R:R:S622	27.2483	3	No	No	0	9	8
54	R:R:M635	R:R:S622	16.7006	6.13	No	No	0	6	8
55	R:R:L625	R:R:M635	13.0797	2.83	No	No	0	4	6
56	R:R:L625	R:R:P631	11.2496	3.28	No	No	0	4	6
57	R:R:C687	R:R:Y641	14.6868	5.38	No	Yes	0	8	7
58	R:R:C687	R:R:H640	12.8895	8.85	No	No	0	8	9
59	R:R:S645	R:R:W680	14.7655	8.65	No	Yes	0	8	8
60	R:R:P683	R:R:S645	12.9419	3.56	Yes	No	0	8	8
61	R:R:H656	R:R:M660	11.407	7.88	Yes	No	0	8	8
62	R:R:L657	R:R:V734	19.3506	5.96	Yes	No	0	9	9
63	R:R:V661	R:R:V734	17.7566	3.21	No	No	0	9	9
64	R:R:L706	R:R:W705	21.2857	13.67	No	Yes	1	9	9
65	R:R:A712	R:R:L706	18.0649	3.15	No	No	0	7	9
66	R:R:A712	R:R:S697	14.4769	3.42	No	No	0	7	7
67	R:R:I549	R:R:N703	18.0584	2.83	No	No	0	8	7
68	R:R:N702	R:R:N703	14.4769	2.72	No	No	0	3	7
69	R:R:N702	R:R:S701	10.8757	4.47	No	No	0	3	3
70	R:R:L731	R:R:L769	22.9583	5.54	Yes	No	0	8	9
71	R:R:L731	R:R:T771	17.9534	2.95	Yes	No	0	8	8
72	R:R:V661	R:R:V737	16.0249	1.6	No	No	0	9	8
73	R:R:Q740	R:R:V737	14.2867	7.16	No	No	0	8	8
74	R:R:Q740	R:R:R736	10.7576	8.18	No	No	0	8	7
75	R:R:L766	R:R:T771	12.7124	5.9	No	No	0	8	8
76	R:R:L766	R:R:S772	10.9347	4.5	No	No	0	8	9
77	R:R:F643	R:R:F716	37.691	3.22	Yes	Yes	0	8	9
78	R:R:N795	R:R:W773	11.8596	19.21	Yes	Yes	1	9	9
79	R:R:V652	R:R:W649	11.3283	7.36	Yes	Yes	2	8	9
80	R:R:F643	R:R:L550	17.3827	7.31	Yes	No	1	8	9
81	R:R:F643	R:R:Q616	46.8088	4.68	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9V0U_nogp

PDB Summary
PDB	9V0U_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	243
Number of Links	275
Number of Hubs	38
Number of Links mediated by Hubs	145
Number of Communities	7
Number of Nodes involved in Communities	53
Number of Links involved in Communities	73

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	39246
Length Of Smallest Path	3
Average Path Length	12.1137
Length of Longest Path	30
Minimum Path Strength	1.435
Average Path Strength	5.75852
Maximum Path Strength	20.185
Minimum Path Correlation	0.7
Average Path Correlation	0.932875
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	54.7098
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.4329
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell surface receptor signaling pathway • multicellular organismal process • system process • nervous system process • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • intracellular organelle lumen • nuclear speck • ribonucleoprotein granule • intracellular organelle • nuclear body • nucleoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • intracellular organelle lumen • nuclear speck • ribonucleoprotein granule • intracellular organelle • nuclear body • nucleoplasm • organelle lumen • organelle • membraneless organelle • supramolecular complex • nuclear ribonucleoprotein granule • nuclear lumen • cytoplasm • cytosol • cell periphery • plasma membrane • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • D5 dopamine receptor binding • dopamine receptor binding • GTPase regulator activity • enzyme regulator activity • guanyl-nucleotide exchange factor activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation • developmental process • cellular developmental process • cell differentiation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of cell motility • regulation of fibroblast migration • fibroblast migration • regulation of locomotion • ameboidal-type cell migration • regulation of cell migration • cell migration • cell motility • locomotion • multicellular organism development • embryo development ending in birth or egg hatching • chordate embryonic development • anatomical structure development • embryo development • in utero embryonic development • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of developmental process • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • branching morphogenesis of an epithelial tube • angiogenesis • tube morphogenesis • epithelial tube morphogenesis • blood vessel development • system development • epithelium development • blood vessel morphogenesis • tube development • morphogenesis of an epithelium • tissue development • vasculature development • circulatory system development • branching involved in blood vessel morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • anatomical structure formation involved in morphogenesis • morphogenesis of a branching epithelium • regulation of cellular component organization • cellular component organization • cellular component biogenesis • cellular component assembly • regulation of postsynapse assembly • cell junction assembly • regulation of synapse structure or activity • synapse organization • cellular component organization or biogenesis • regulation of synapse assembly • postsynapse organization • postsynapse assembly • regulation of postsynapse organization • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • Rho-activating G protein-coupled receptor signaling pathway • regulation of signaling • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • regulation of signal transduction • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • intracellular signaling cassette • regulation of cell communication • Rho protein signal transduction • anchoring junction • cell junction • focal adhesion • cell-substrate junction • pigment granule • intracellular vesicle • melanosome • cytoplasmic vesicle • vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • brush border membrane • cluster of actin-based cell projections • plasma membrane bounded cell projection • brush border • cell projection • apical part of cell • plasma membrane region • apical plasma membrane • cell projection membrane • postsynapse • synapse • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q6QNK2
Sequence	>9V0U_nogp_Chain_R N F A I L M Q V V P L E L A R G H Q V A L S S I S Y V G C S L S V L C L V A T L V T F A V L S S V S T I R N Q R Y H I H A N L S F A V L V A Q V L L L I S F R L E P G T T P C Q V M A V L L H Y F F L S A F A W M L V E G L H L Y S M V I K V F G S E D S K H R Y Y Y G M G W G F P L L I C I I S L S F A M D S Y G T S N N C W L S L A S G A I W A F V A P A L F V I V V N I G I L I A V T R V I S Q I S A D N F K L T A K A V A V L L P I L G T S W V F G V L A V A V V F Q Y M F A T L N S L Q G L F I F L F H C L L N S E V R A A F K H K T K V W S L T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9V0U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9V0U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165

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