psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L619	7.91	Yes	No	1	0	9
2	L:L:?1	R:R:F623	5.57	Yes	No	1	0	6
3	L:L:?1	R:R:F643	8.36	Yes	No	0	0	8
4	L:L:?1	R:R:W705	17.58	Yes	Yes	0	0	9
5	L:L:?1	R:R:F716	14.62	Yes	No	0	0	9
6	L:L:?1	R:R:W773	7.16	Yes	Yes	1	0	9
7	L:L:?1	R:R:F787	9.75	Yes	Yes	1	0	7
8	L:L:?1	R:R:F791	31.34	Yes	No	1	0	9
9	L:L:?1	R:R:N795	5.5	Yes	Yes	1	0	9
10	R:R:I569	R:R:Y789	8.46	No	No	0	9	9
11	R:R:F623	R:R:S570	6.61	No	No	0	6	7
12	R:R:L620	R:R:Y571	14.07	No	No	0	8	7
13	R:R:C574	R:R:L620	4.76	No	No	0	8	8
14	R:R:C574	R:R:N795	4.72	No	Yes	0	8	9
15	R:R:Q616	R:R:S577	8.66	Yes	No	0	8	9
16	R:R:Q616	R:R:V578	4.3	Yes	No	0	8	7
17	R:R:C580	R:R:F803	9.78	No	Yes	0	7	9
18	R:R:G799	R:R:L581	5.13	No	No	0	8	9
19	R:R:L613	R:R:V582	4.47	No	No	0	8	4
20	R:R:A583	R:R:F803	4.16	No	Yes	0	6	9
21	R:R:F588	R:R:T584	5.19	No	No	0	7	9
22	R:R:F803	R:R:T584	6.49	Yes	No	5	9	9
23	R:R:C807	R:R:T584	5.07	No	No	5	8	9
24	R:R:L585	R:R:S609	4.5	No	No	0	7	8
25	R:R:C807	R:R:T587	5.07	No	No	0	8	8
26	R:R:F588	R:R:Y602	6.19	No	Yes	0	7	8
27	R:R:L591	R:R:V590	4.47	Yes	No	0	8	4
28	R:R:I597	R:R:L591	4.28	No	Yes	0	8	8
29	R:R:A816	R:R:L591	4.73	No	Yes	0	8	8
30	R:R:K820	R:R:S593	6.12	No	No	0	8	8
31	R:R:T596	R:R:V594	4.76	No	Yes	0	9	8
32	R:R:A816	R:R:V594	5.09	No	Yes	0	8	8
33	R:R:I597	R:R:T596	4.56	No	No	0	8	9
34	R:R:I597	R:R:Y602	14.51	No	Yes	0	8	8
35	R:R:N599	R:R:R601	8.44	No	Yes	4	8	8
36	R:R:N599	R:R:Y602	5.81	No	Yes	4	8	8
37	R:R:H656	R:R:Q600	4.95	Yes	No	2	8	8
38	R:R:H672	R:R:Q600	14.84	No	No	0	7	8
39	R:R:Q600	R:R:Y675	7.89	No	Yes	2	8	8
40	R:R:R601	R:R:Y602	11.32	Yes	Yes	4	8	8
41	R:R:H605	R:R:R601	4.51	Yes	Yes	4	9	8
42	R:R:E812	R:R:R601	5.82	No	Yes	4	8	8
43	R:R:H605	R:R:Y602	4.36	Yes	Yes	4	9	8
44	R:R:N810	R:R:Y602	4.65	No	Yes	0	9	8
45	R:R:E812	R:R:Y602	6.73	No	Yes	4	8	8
46	R:R:H603	R:R:H672	4.78	No	No	0	8	7
47	R:R:I604	R:R:W649	5.87	Yes	Yes	2	9	9
48	R:R:I604	R:R:V652	7.68	Yes	Yes	2	9	8
49	R:R:E653	R:R:I604	10.93	No	Yes	0	9	9
50	R:R:H656	R:R:I604	5.3	Yes	Yes	2	8	9
51	R:R:I604	R:R:Y675	4.84	Yes	Yes	2	9	8
52	R:R:E653	R:R:H605	12.31	No	Yes	0	9	9
53	R:R:H605	R:R:H806	7.17	Yes	Yes	0	9	9
54	R:R:N607	R:R:W649	19.21	No	Yes	2	9	9
55	R:R:N607	R:R:Y676	12.79	No	No	2	9	8
56	R:R:Q616	R:R:V612	4.3	Yes	No	0	8	8
57	R:R:Q798	R:R:V612	4.3	Yes	No	0	9	8
58	R:R:F642	R:R:V614	17.04	No	No	0	8	6
59	R:R:A615	R:R:F643	9.71	No	No	0	9	8
60	R:R:N795	R:R:Q616	14.52	Yes	Yes	0	9	8
61	R:R:L618	R:R:M635	5.65	Yes	No	0	7	6
62	R:R:L618	R:R:L638	4.15	Yes	No	0	7	7
63	R:R:F642	R:R:L618	4.87	No	Yes	0	8	7
64	R:R:F623	R:R:L619	4.87	No	No	1	6	9
65	R:R:I621	R:R:M635	5.83	No	No	0	4	6
66	R:R:M635	R:R:S622	9.2	No	No	0	6	8
67	R:R:S622	R:R:W705	4.94	No	Yes	0	8	9
68	R:R:L625	R:R:P631	4.93	No	No	0	4	6
69	R:R:E626	R:R:T629	5.64	No	No	0	2	8
70	R:R:P631	R:R:T629	6.99	No	No	0	6	8
71	R:R:C632	R:R:C704	7.28	No	No	0	9	9
72	R:R:L691	R:R:V637	5.96	No	No	3	4	4
73	R:R:V637	R:R:Y698	6.31	No	Yes	3	4	9
74	R:R:H640	R:R:L644	5.14	Yes	No	0	9	9
75	R:R:C687	R:R:H640	11.79	No	Yes	0	8	9
76	R:R:H640	R:R:S690	4.18	Yes	No	3	9	8
77	R:R:H640	R:R:Y698	13.07	Yes	Yes	3	9	9
78	R:R:H640	R:R:L706	7.71	Yes	No	3	9	9
79	R:R:F716	R:R:H640	6.79	No	Yes	0	9	9
80	R:R:F642	R:R:Y641	4.13	No	No	0	8	7
81	R:R:W680	R:R:Y641	9.65	Yes	No	0	8	7
82	R:R:L684	R:R:Y641	4.69	No	No	0	5	7
83	R:R:L644	R:R:P683	4.93	No	Yes	0	9	8
84	R:R:I686	R:R:L644	4.28	No	No	0	7	9
85	R:R:S645	R:R:W680	12.36	No	Yes	0	8	8
86	R:R:F647	R:R:F716	5.36	Yes	No	0	9	9
87	R:R:A720	R:R:F647	5.55	No	Yes	0	9	9
88	R:R:F647	R:R:I724	6.28	Yes	No	0	9	9
89	R:R:F647	R:R:W773	10.02	Yes	Yes	0	9	9
90	R:R:V652	R:R:W649	6.13	Yes	Yes	2	8	9
91	R:R:W649	R:R:Y676	8.68	Yes	No	2	9	8
92	R:R:G679	R:R:W649	8.44	No	Yes	0	9	9
93	R:R:W649	R:R:W680	14.06	Yes	Yes	0	9	8
94	R:R:M650	R:R:W773	4.65	No	Yes	1	9	9
95	R:R:M650	R:R:Q798	9.52	No	Yes	1	9	9
96	R:R:L651	R:R:M678	4.24	No	No	0	9	7
97	R:R:L651	R:R:V723	13.41	No	No	0	9	8
98	R:R:V652	R:R:Y675	11.36	Yes	Yes	2	8	8
99	R:R:M678	R:R:V652	6.09	No	Yes	0	7	8
100	R:R:E653	R:R:I768	15.03	No	No	0	9	8
101	R:R:G654	R:R:N727	5.09	No	No	0	9	9
102	R:R:H656	R:R:M660	10.51	Yes	No	0	8	8
103	R:R:H656	R:R:Y675	11.98	Yes	Yes	2	8	8
104	R:R:L657	R:R:V734	5.96	No	No	0	9	9
105	R:R:L657	R:R:L765	6.92	No	No	0	9	9
106	R:R:I662	R:R:Y658	15.71	No	No	0	8	8
107	R:R:K663	R:R:Y658	5.97	No	No	0	7	8
108	R:R:I730	R:R:Y658	6.04	No	No	0	8	8
109	R:R:M660	R:R:S667	6.13	No	No	0	8	8
110	R:R:V661	R:R:V734	4.81	No	No	0	9	9
111	R:R:F665	R:R:V664	5.24	No	No	0	8	9
112	R:R:D669	R:R:G666	5.03	No	No	0	6	7
113	R:R:H672	R:R:S670	5.58	No	No	0	7	7
114	R:R:K671	R:R:Y675	5.97	No	Yes	0	8	8
115	R:R:I686	R:R:P719	5.08	No	No	0	7	9
116	R:R:F693	R:R:I689	8.79	No	No	0	5	6
117	R:R:S690	R:R:Y698	5.09	No	Yes	3	8	9
118	R:R:L691	R:R:Y698	7.03	No	Yes	3	4	9
119	R:R:F693	R:R:S692	6.61	No	No	0	5	6
120	R:R:D696	R:R:S697	4.42	No	No	0	3	7
121	R:R:L706	R:R:Y698	15.24	No	Yes	3	9	9
122	R:R:N702	R:R:S701	4.47	No	No	0	3	3
123	R:R:N702	R:R:N703	16.35	No	No	0	3	7
124	R:R:N703	R:R:W705	15.82	No	Yes	0	7	9
125	R:R:L708	R:R:W705	7.97	No	Yes	0	7	9
126	R:R:F787	R:R:L708	10.96	Yes	No	0	7	7
127	R:R:V717	R:R:W714	7.36	No	No	0	8	8
128	R:R:L721	R:R:V777	4.47	No	No	0	7	7
129	R:R:N727	R:R:V723	4.43	No	No	0	9	8
130	R:R:L769	R:R:N727	9.61	No	No	0	9	9
131	R:R:L731	R:R:L765	4.15	No	No	0	8	9
132	R:R:Q740	R:R:V737	4.3	No	No	0	8	8
133	R:R:I741	R:R:Q740	6.86	No	No	0	8	8
134	R:R:L757	R:R:S742	4.5	No	No	0	8	8
135	R:R:K756	R:R:S753	6.12	No	No	0	6	6
136	R:R:F805	R:R:V764	5.24	No	No	0	8	8
137	R:R:L765	R:R:L769	5.54	No	No	0	9	9
138	R:R:L766	R:R:T771	7.37	No	No	0	8	8
139	R:R:F801	R:R:P767	5.78	No	No	0	8	9
140	R:R:H806	R:R:P767	6.1	Yes	No	0	9	9
141	R:R:I768	R:R:L769	4.28	No	No	0	8	9
142	R:R:H806	R:R:I768	15.91	Yes	No	0	9	8
143	R:R:L794	R:R:S772	4.5	No	No	0	6	9
144	R:R:L794	R:R:W773	9.11	No	Yes	0	6	9
145	R:R:N795	R:R:W773	10.17	Yes	Yes	1	9	9
146	R:R:Q798	R:R:W773	10.95	Yes	Yes	1	9	9
147	R:R:F791	R:R:G776	4.52	No	No	0	9	9
148	R:R:N781	R:R:V780	10.35	No	No	0	7	7
149	R:R:F787	R:R:F791	11.79	Yes	No	1	7	9
150	R:R:Q788	R:R:Y789	32.69	No	No	0	8	9
151	R:R:F801	R:R:L797	13.4	No	No	0	8	7
152	R:R:I802	R:R:Q798	4.12	No	Yes	0	8	9
153	R:R:G799	R:R:I802	5.29	No	No	0	8	8
154	R:R:L800	R:R:L804	4.15	No	No	0	6	8
155	R:R:C807	R:R:F803	5.59	No	Yes	5	8	9
156	R:R:L808	R:R:L809	4.15	No	No	0	7	8
157	R:R:N810	R:R:V813	7.39	No	No	0	9	9
158	R:R:F817	R:R:T821	5.19	No	No	0	7	8
159	R:R:H819	R:R:V823	4.15	No	No	0	8	7
160	R:R:K820	R:R:W824	8.12	No	No	0	8	7
161	R:R:K822	R:R:L826	4.23	No	No	0	8	8
162	R:R:M695	R:R:Q633	4.08	No	No	0	2	5
163	R:R:R814	R:R:S811	3.95	No	No	0	9	8
164	R:R:F610	R:R:V614	3.93	No	No	0	4	6
165	R:R:F722	R:R:V726	3.93	No	No	0	5	8
166	R:R:F775	R:R:V774	3.93	No	No	0	8	5
167	R:R:I732	R:R:R736	3.76	No	No	0	4	7
168	R:R:A648	R:R:P683	3.74	No	Yes	0	7	8
169	R:R:G711	R:R:S710	3.71	No	No	0	7	4
170	R:R:G573	R:R:V572	3.68	No	No	0	9	5
171	R:R:F610	R:R:L585	3.65	No	No	0	4	7
172	R:R:F803	R:R:L808	3.65	Yes	No	0	9	7
173	R:R:G699	R:R:T700	3.64	No	No	0	8	4
174	R:R:G654	R:R:I730	3.53	No	No	0	9	8
175	R:R:G729	R:R:I728	3.53	No	No	0	5	5
176	R:R:I713	R:R:W714	3.52	No	No	0	8	8
177	R:R:P631	R:R:T630	3.5	No	No	0	6	3
178	R:R:G770	R:R:M650	3.49	No	No	0	9	9
179	R:R:A715	R:R:S690	3.42	No	No	0	9	8
180	R:R:A712	R:R:S697	3.42	No	No	0	7	7
181	R:R:A754	R:R:S742	3.42	No	No	0	8	8
182	R:R:S697	R:R:S707	3.26	No	No	0	7	8
183	R:R:C580	R:R:L800	3.17	No	No	0	7	6
184	R:R:I569	R:R:S568	3.1	No	No	0	9	5
185	R:R:I724	R:R:V774	3.07	No	No	0	9	5
186	R:R:I738	R:R:V734	3.07	No	No	0	9	9
187	R:R:K820	R:R:V594	3.04	No	Yes	0	8	8
188	R:R:I728	R:R:T771	3.04	No	No	0	5	8
189	R:R:L639	R:R:S622	3	No	No	0	9	8
190	R:R:L797	R:R:S796	3	No	No	0	7	9
191	R:R:L613	R:R:V578	2.98	No	No	0	8	7
192	R:R:L608	R:R:V612	2.98	No	No	0	9	8
193	R:R:L618	R:R:V617	2.98	Yes	No	0	7	5
194	R:R:L651	R:R:V726	2.98	No	No	0	9	8
195	R:R:L721	R:R:V717	2.98	No	No	0	7	8
196	R:R:L797	R:R:T793	2.95	No	No	0	7	5
197	R:R:Q788	R:R:S570	2.89	No	No	0	8	7
198	R:R:I688	R:R:L684	2.85	No	No	0	4	5
199	R:R:L655	R:R:M678	2.83	No	No	0	7	7
200	R:R:L691	R:R:M695	2.83	No	No	0	4	2
201	R:R:L794	R:R:M790	2.83	No	No	0	6	5
202	R:R:A763	R:R:F805	2.77	No	No	0	7	8
203	R:R:A779	R:R:F787	2.77	No	Yes	0	8	7
204	R:R:A636	R:R:Y698	2.67	No	Yes	0	9	9
205	R:R:A611	R:R:W680	2.59	No	Yes	0	8	8
206	L:L:?1	R:R:V717	2.56	Yes	No	0	0	8
207	R:R:F817	R:R:L591	2.44	No	Yes	0	7	8
208	R:R:F805	R:R:H806	2.26	No	Yes	0	8	9
209	R:R:G681	R:R:P683	2.03	No	Yes	0	9	8
210	R:R:C632	R:R:G699	1.96	No	No	0	9	8
211	R:R:C783	R:R:G782	1.96	No	No	0	4	3
212	R:R:A636	R:R:G699	1.95	No	No	0	9	8
213	R:R:A718	R:R:P719	1.87	No	No	0	7	9
214	R:R:G573	R:R:S796	1.86	No	No	0	9	9
215	R:R:G711	R:R:S707	1.86	No	No	0	7	8
216	R:R:G770	R:R:T771	1.82	No	No	0	9	8
217	R:R:A779	R:R:C783	1.81	No	No	0	8	4
218	R:R:A611	R:R:A646	1.79	No	No	0	8	7
219	R:R:A694	R:R:A712	1.79	No	No	0	6	7
220	R:R:G729	R:R:I732	1.76	No	No	0	5	4
221	R:R:A792	R:R:S570	1.71	No	No	0	8	7
222	R:R:G573	R:R:L576	1.71	No	No	0	9	5
223	L:L:?1	R:R:V780	1.7	Yes	No	0	0	7
224	R:R:G782	R:R:N781	1.7	No	No	0	3	7
225	R:R:A784	R:R:V786	1.7	No	No	0	6	5
226	R:R:C632	R:R:T629	1.69	No	No	0	9	8
227	R:R:N703	R:R:P627	1.63	No	No	0	7	5
228	R:R:S659	R:R:S667	1.63	No	No	0	8	8
229	R:R:A733	R:R:I662	1.62	No	No	0	8	8
230	R:R:A761	R:R:I738	1.62	No	No	0	9	9
231	R:R:V582	R:R:V586	1.6	No	No	0	4	6
232	R:R:V725	R:R:V726	1.6	No	No	0	4	8
233	R:R:S739	R:R:T758	1.6	No	No	0	8	8
234	R:R:T735	R:R:V762	1.59	No	No	0	9	8
235	R:R:A606	R:R:L585	1.58	No	No	0	7	7
236	R:R:T735	R:R:T758	1.57	No	No	0	9	8
237	R:R:I662	R:R:V737	1.54	No	No	0	8	8
238	R:R:A743	R:R:D744	1.54	No	No	0	5	6
239	R:R:K822	R:R:S825	1.53	No	No	0	8	8
240	R:R:M790	R:R:V786	1.52	No	No	0	5	5
241	R:R:N745	R:R:S742	1.49	No	No	0	6	8
242	R:R:L766	R:R:V762	1.49	No	No	0	8	8
243	R:R:L778	R:R:V777	1.49	No	No	0	7	7
244	R:R:F682	R:R:P683	1.44	No	Yes	0	4	8
245	R:R:H819	R:R:V594	1.38	No	Yes	0	8	8
246	R:R:D669	R:R:K671	1.38	No	No	0	6	8
247	R:R:L808	R:R:R814	1.21	No	No	0	7	9
248	R:R:K671	R:R:Y674	1.19	No	No	0	8	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.1864	11	1	0
2	R:R:L591	3.98	4	0	8
3	R:R:V594	3.5675	4	0	8
4	R:R:R601	7.5225	4	4	8
5	R:R:Y602	7.65286	7	4	8
6	R:R:I604	6.924	5	2	9
7	R:R:H605	7.0875	4	4	9
8	R:R:Q616	7.945	4	0	8
9	R:R:L618	4.4125	4	0	7
10	R:R:H640	8.11333	6	3	9
11	R:R:F647	6.8025	4	0	9
12	R:R:W649	10.3983	6	2	9
13	R:R:V652	7.815	4	2	8
14	R:R:H656	8.185	4	2	8
15	R:R:Y675	8.408	5	2	8
16	R:R:W680	9.665	4	0	8
17	R:R:P683	3.035	4	0	8
18	R:R:Y698	8.235	6	3	9
19	R:R:W705	11.5775	4	0	9
20	R:R:W773	8.67667	6	1	9
21	R:R:F787	8.8175	4	1	7
22	R:R:N795	8.7275	4	1	9
23	R:R:Q798	7.2225	4	1	9
24	R:R:F803	5.934	5	5	9
25	R:R:H806	7.86	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F623	10.2894	5.57	Yes	No	1	0	6
2	L:L:?1	R:R:N795	15.2525	5.5	Yes	Yes	1	0	9
3	R:R:N795	R:R:Q616	11.3362	14.52	Yes	Yes	0	9	8
4	L:L:?1	R:R:W705	93.1897	17.58	Yes	Yes	0	0	9
5	R:R:S622	R:R:W705	97.58	4.94	No	Yes	0	8	9
6	R:R:M635	R:R:S622	98.2389	9.2	No	No	0	6	8
7	R:R:L618	R:R:M635	98.516	5.65	Yes	No	0	7	6
8	R:R:F642	R:R:L618	99.0394	4.87	No	Yes	0	8	7
9	R:R:F642	R:R:Y641	99.7414	4.13	No	No	0	8	7
10	R:R:W680	R:R:Y641	99.9261	9.65	Yes	No	0	8	7
11	R:R:W649	R:R:W680	100	14.06	Yes	Yes	0	9	8
12	R:R:I604	R:R:W649	78.0234	5.87	Yes	Yes	2	9	9
13	R:R:E653	R:R:I604	74.1995	10.93	No	Yes	0	9	9
14	R:R:E653	R:R:H605	49.1564	12.31	No	Yes	0	9	9
15	R:R:H605	R:R:Y602	39.7044	4.36	Yes	Yes	4	9	8
16	R:R:F588	R:R:Y602	18.4852	6.19	No	Yes	0	7	8
17	R:R:F588	R:R:T584	17.1367	5.19	No	No	0	7	9
18	R:R:F803	R:R:T584	12.9064	6.49	Yes	No	5	9	9
19	L:L:?1	R:R:W773	35.9052	7.16	Yes	Yes	1	0	9
20	R:R:I597	R:R:Y602	18.0296	14.51	No	Yes	0	8	8
21	R:R:H656	R:R:I604	10.4064	5.3	Yes	Yes	2	8	9
22	R:R:I604	R:R:Y675	11.798	4.84	Yes	Yes	2	9	8
23	R:R:H672	R:R:Q600	10.6404	14.84	No	No	0	7	8
24	R:R:V652	R:R:W649	21.8473	6.13	Yes	Yes	2	8	9
25	R:R:H605	R:R:H806	17.9187	7.17	Yes	Yes	0	9	9
26	R:R:E653	R:R:I768	32.7278	15.03	No	No	0	9	8
27	R:R:H806	R:R:I768	17.0751	15.91	Yes	No	0	9	8
28	L:L:?1	R:R:F716	43.0911	14.62	Yes	No	0	0	9
29	R:R:F716	R:R:H640	41.5702	6.79	No	Yes	0	9	9
30	R:R:H640	R:R:Y698	23.2943	13.07	Yes	Yes	3	9	9
31	R:R:A636	R:R:Y698	16.25	2.67	No	Yes	0	9	9
32	R:R:A636	R:R:G699	14.6798	1.95	No	No	0	9	8
33	R:R:C632	R:R:G699	11.5025	1.96	No	No	0	9	8
34	R:R:H640	R:R:L644	12.9865	5.14	Yes	No	0	9	9
35	R:R:F647	R:R:W773	10.819	10.02	Yes	Yes	0	9	9
36	R:R:F647	R:R:F716	10.5603	5.36	Yes	No	0	9	9
37	R:R:M650	R:R:W773	18.67	4.65	No	Yes	1	9	9
38	R:R:M678	R:R:V652	16.8042	6.09	No	Yes	0	7	8
39	R:R:L651	R:R:M678	14.4643	4.24	No	No	0	9	7
40	R:R:L651	R:R:V723	10.5727	13.41	No	No	0	9	8
41	R:R:I768	R:R:L769	25.936	4.28	No	No	0	8	9
42	R:R:L769	R:R:N727	15.8005	9.61	No	No	0	9	9
43	R:R:G654	R:R:N727	21.3054	5.09	No	No	0	9	9
44	R:R:N727	R:R:V723	10.2278	4.43	No	No	0	9	8
45	R:R:L765	R:R:L769	10.2894	5.54	No	No	0	9	9
46	R:R:G654	R:R:I730	18.9286	3.53	No	No	0	9	8
47	R:R:I730	R:R:Y658	16.5271	6.04	No	No	0	8	8
48	R:R:I662	R:R:Y658	11.9704	15.71	No	No	0	8	8
49	R:R:G770	R:R:M650	17.9557	3.49	No	No	0	9	9
50	R:R:G770	R:R:T771	16.3424	1.82	No	No	0	9	8
51	R:R:H806	R:R:P767	18.3621	6.1	Yes	No	0	9	9
52	R:R:F801	R:R:P767	16.1145	5.78	No	No	0	8	9
53	R:R:F801	R:R:L797	13.8485	13.4	No	No	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L619	7.91	1	Yes	No	0	9	0	1
L:L:?1	R:R:F623	5.57	1	Yes	No	0	6	0	1
L:L:?1	R:R:F643	8.36	1	Yes	No	0	8	0	1
L:L:?1	R:R:W705	17.58	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F716	14.62	1	Yes	No	0	9	0	1
L:L:?1	R:R:W773	7.16	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F787	9.75	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F791	31.34	1	Yes	No	0	9	0	1
L:L:?1	R:R:N795	5.5	1	Yes	Yes	0	9	0	1
R:R:F623	R:R:S570	6.61	1	No	No	6	7	1	2
R:R:C574	R:R:N795	4.72	0	No	Yes	8	9	2	1
R:R:A615	R:R:F643	9.71	0	No	No	9	8	2	1
R:R:N795	R:R:Q616	14.52	1	Yes	Yes	9	8	1	2
R:R:F623	R:R:L619	4.87	1	No	No	6	9	1	1
R:R:S622	R:R:W705	4.94	0	No	Yes	8	9	2	1
R:R:F716	R:R:H640	6.79	0	No	Yes	9	9	1	2
R:R:F647	R:R:F716	5.36	0	Yes	No	9	9	2	1
R:R:F647	R:R:W773	10.02	0	Yes	Yes	9	9	2	1
R:R:M650	R:R:W773	4.65	1	No	Yes	9	9	2	1
R:R:M650	R:R:Q798	9.52	1	No	Yes	9	9	2	2
R:R:N703	R:R:W705	15.82	0	No	Yes	7	9	2	1
R:R:L708	R:R:W705	7.97	0	No	Yes	7	9	2	1
R:R:F787	R:R:L708	10.96	1	Yes	No	7	7	1	2
R:R:V717	R:R:W714	7.36	0	No	No	8	8	1	2
R:R:L794	R:R:W773	9.11	0	No	Yes	6	9	2	1
R:R:N795	R:R:W773	10.17	1	Yes	Yes	9	9	1	1
R:R:Q798	R:R:W773	10.95	1	Yes	Yes	9	9	2	1
R:R:F791	R:R:G776	4.52	1	No	No	9	9	1	2
R:R:N781	R:R:V780	10.35	0	No	No	7	7	2	1
R:R:F787	R:R:F791	11.79	1	Yes	No	7	9	1	1
R:R:L721	R:R:V717	2.98	0	No	No	7	8	2	1
R:R:A779	R:R:F787	2.77	0	No	Yes	8	7	2	1
L:L:?1	R:R:V717	2.56	1	Yes	No	0	8	0	1
L:L:?1	R:R:V780	1.7	1	Yes	No	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8X9T_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.11
Number of Linked Nodes	233
Number of Links	248
Number of Hubs	25
Number of Links mediated by Hubs	100
Number of Communities	5
Number of Nodes involved in Communities	31
Number of Links involved in Communities	42

Path Summary
Number Of Nodes in MetaPath	54
Number Of Links MetaPath	53
Number of Shortest Paths	29764
Length Of Smallest Path	3
Average Path Length	13.6621
Length of Longest Path	30
Minimum Path Strength	1.285
Average Path Strength	7.5772
Maximum Path Strength	24.46
Minimum Path Correlation	0.7
Average Path Correlation	0.918432
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	44.4575
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.8586
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell surface receptor signaling pathway • multicellular organismal process • system process • nervous system process • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • intracellular organelle lumen • nuclear speck • ribonucleoprotein granule • intracellular organelle • nuclear body • nucleoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • intracellular organelle lumen • nuclear speck • ribonucleoprotein granule • intracellular organelle • nuclear body • nucleoplasm • organelle lumen • organelle • membraneless organelle • supramolecular complex • nuclear ribonucleoprotein granule • nuclear lumen • cytoplasm • cytosol • cell periphery • plasma membrane • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • molecular function regulator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • insulin-like growth factor receptor binding • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YNH
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YNH
Name	methyl 3-[2-(2,4-dimethylphenoxy)ethanoylamino]-4-(4-ethylpiperazin-1-yl)benzoate
Synonyms
Identifier
Formula	C24 H31 N3 O4
Molecular Weight	425.521
SMILES
PubChem	7346086
Formal Charge	0
Total Atoms	62
Total Chiral Atoms	0
Total Bonds	64
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q6QNK2
Sequence	>8X9T_nogp_Chain_R S I S Y V G C S L S V L C L V A T L V T F A V L S S V S T I R N Q R Y H I H A N L S F A V L V A Q V L L L I S F R L E P G T T P C Q V M A V L L H Y F F L S A F A W M L V E G L H L Y S M V I K V F G S E D S K H R Y Y Y G M G W G F P L L I C I I S L S F A M D S Y G T S N N C W L S L A S G A I W A F V A P A L F V I V V N I G I L I A V T R V I S Q I S A D N S A F K L T A K A V A V L L P I L G T S W V F G V L A V N G C A V V F Q Y M F A T L N S L Q G L F I F L F H C L L N S E V R A A F K H K T K V W S L T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9V0U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9V0U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.