psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L619	8.83	Yes	No	2	0	9
2	L:L:?1	R:R:H640	5.86	Yes	Yes	2	0	9
3	L:L:?1	R:R:W705	21.8	Yes	Yes	2	0	9
4	L:L:?1	R:R:L706	13.87	Yes	No	2	0	9
5	L:L:?1	R:R:I713	9.1	Yes	No	0	0	8
6	L:L:?1	R:R:F716	16.65	Yes	Yes	2	0	9
7	L:L:?1	R:R:F791	7.77	Yes	No	0	0	9
8	R:R:H562	R:R:V564	15.22	No	No	0	7	5
9	R:R:A565	R:R:Y789	4	No	No	0	6	9
10	R:R:L566	R:R:Y789	8.21	No	No	0	9	9
11	R:R:I569	R:R:S568	4.64	Yes	No	0	9	5
12	R:R:S570	R:R:S796	3.26	No	No	0	7	9
13	R:R:C574	R:R:S577	3.44	No	No	3	8	9
14	R:R:C574	R:R:Q616	6.1	No	No	3	8	8
15	R:R:C574	R:R:L620	6.35	No	No	0	8	8
16	R:R:L576	R:R:L800	4.15	No	No	0	5	6
17	R:R:Q616	R:R:S577	11.55	No	No	3	8	9
18	R:R:V578	R:R:V617	3.21	No	No	4	7	5
19	R:R:C580	R:R:F803	9.78	No	Yes	0	7	9
20	R:R:L581	R:R:T584	4.42	Yes	Yes	0	9	9
21	R:R:L581	R:R:L613	5.54	Yes	Yes	0	9	8
22	R:R:G799	R:R:L581	5.13	No	Yes	0	8	9
23	R:R:A583	R:R:F803	4.16	No	Yes	0	6	9
24	R:R:S609	R:R:T584	4.8	No	Yes	0	8	9
25	R:R:F803	R:R:T584	6.49	Yes	Yes	1	9	9
26	R:R:C807	R:R:T584	6.76	Yes	Yes	1	8	9
27	R:R:L585	R:R:S609	4.5	No	No	0	7	8
28	R:R:F610	R:R:L585	4.87	No	No	0	4	7
29	R:R:C807	R:R:T587	3.38	Yes	No	0	8	8
30	R:R:F588	R:R:Y602	8.25	No	Yes	1	7	8
31	R:R:C807	R:R:F588	6.98	Yes	No	1	8	7
32	R:R:F588	R:R:V813	3.93	No	No	1	7	9
33	R:R:V590	R:R:W824	4.9	No	No	0	4	7
34	R:R:A816	R:R:L591	4.73	No	No	0	8	8
35	R:R:F817	R:R:L591	4.87	No	No	0	7	8
36	R:R:K820	R:R:L591	4.23	No	No	0	8	8
37	R:R:K820	R:R:S593	6.12	No	No	0	8	8
38	R:R:I597	R:R:V594	4.61	No	No	1	8	8
39	R:R:A816	R:R:V594	5.09	No	No	1	8	8
40	R:R:E812	R:R:T596	7.06	No	No	0	8	9
41	R:R:I597	R:R:Y602	14.51	No	Yes	1	8	8
42	R:R:A816	R:R:I597	3.25	No	No	1	8	8
43	R:R:N599	R:R:Y602	5.81	No	Yes	0	8	8
44	R:R:H656	R:R:Q600	7.42	Yes	Yes	1	8	8
45	R:R:K671	R:R:Q600	8.14	Yes	Yes	1	8	8
46	R:R:H672	R:R:Q600	19.78	No	Yes	0	7	8
47	R:R:Q600	R:R:Y675	6.76	Yes	Yes	1	8	8
48	R:R:R601	R:R:Y602	11.32	Yes	Yes	1	8	8
49	R:R:H605	R:R:R601	4.51	Yes	Yes	1	9	8
50	R:R:H656	R:R:R601	3.39	Yes	Yes	1	8	8
51	R:R:E812	R:R:R601	9.3	No	Yes	1	8	8
52	R:R:H605	R:R:Y602	3.27	Yes	Yes	1	9	8
53	R:R:N810	R:R:Y602	4.65	No	Yes	0	9	8
54	R:R:E812	R:R:Y602	5.61	No	Yes	1	8	8
55	R:R:V813	R:R:Y602	5.05	No	Yes	1	9	8
56	R:R:H603	R:R:H672	5.97	No	No	0	8	7
57	R:R:H603	R:R:Y676	4.36	No	No	0	8	8
58	R:R:I604	R:R:W649	7.05	Yes	Yes	1	9	9
59	R:R:I604	R:R:V652	6.14	Yes	Yes	1	9	8
60	R:R:E653	R:R:I604	10.93	No	Yes	1	9	9
61	R:R:H656	R:R:I604	5.3	Yes	Yes	1	8	9
62	R:R:I604	R:R:Y675	3.63	Yes	Yes	1	9	8
63	R:R:E653	R:R:H605	13.54	No	Yes	1	9	9
64	R:R:H605	R:R:I768	3.98	Yes	No	1	9	8
65	R:R:H605	R:R:H806	11.94	Yes	No	1	9	9
66	R:R:N607	R:R:W649	19.21	No	Yes	1	9	9
67	R:R:N607	R:R:Y676	11.63	No	No	1	9	8
68	R:R:N607	R:R:W680	6.78	No	Yes	1	9	8
69	R:R:L608	R:R:W649	3.42	No	Yes	0	9	9
70	R:R:F610	R:R:V614	7.87	No	No	0	4	6
71	R:R:Q616	R:R:V612	5.73	No	No	0	8	8
72	R:R:F642	R:R:V614	17.04	No	No	0	8	6
73	R:R:A615	R:R:F643	8.32	No	No	0	9	8
74	R:R:L618	R:R:L638	4.15	No	No	0	7	7
75	R:R:L618	R:R:L639	6.92	No	No	0	7	9
76	R:R:F623	R:R:L619	10.96	Yes	No	2	6	9
77	R:R:L619	R:R:W705	3.42	No	Yes	2	9	9
78	R:R:M635	R:R:S622	3.07	No	No	0	6	8
79	R:R:S622	R:R:W705	4.94	No	Yes	0	8	9
80	R:R:F623	R:R:W705	4.01	Yes	Yes	2	6	9
81	R:R:L625	R:R:P631	8.21	No	No	0	4	6
82	R:R:P631	R:R:T630	6.99	No	No	0	6	3
83	R:R:C632	R:R:C704	5.46	No	No	0	9	9
84	R:R:Q633	R:R:Y698	3.38	No	Yes	0	5	9
85	R:R:G699	R:R:Q633	4.93	No	No	0	8	5
86	R:R:L639	R:R:M635	4.24	No	No	0	9	6
87	R:R:C704	R:R:M635	6.48	No	No	0	9	6
88	R:R:A636	R:R:Y698	4	No	Yes	0	9	9
89	R:R:L691	R:R:V637	4.47	No	No	2	4	4
90	R:R:V637	R:R:Y698	7.57	No	Yes	2	4	9
91	R:R:F642	R:R:L638	7.31	No	No	0	8	7
92	R:R:F643	R:R:L639	8.53	No	No	0	8	9
93	R:R:H640	R:R:L644	9	Yes	Yes	2	9	9
94	R:R:C687	R:R:H640	5.9	No	Yes	0	8	9
95	R:R:H640	R:R:Y698	5.44	Yes	Yes	2	9	9
96	R:R:H640	R:R:L706	10.29	Yes	No	2	9	9
97	R:R:F716	R:R:H640	5.66	Yes	Yes	2	9	9
98	R:R:W680	R:R:Y641	9.65	Yes	No	0	8	7
99	R:R:P683	R:R:Y641	4.17	Yes	No	0	8	7
100	R:R:L684	R:R:Y641	3.52	No	No	0	5	7
101	R:R:F642	R:R:W680	4.01	No	Yes	0	8	8
102	R:R:L644	R:R:P683	3.28	Yes	Yes	0	9	8
103	R:R:I686	R:R:L644	5.71	No	Yes	2	7	9
104	R:R:F716	R:R:L644	4.87	Yes	Yes	2	9	9
105	R:R:L644	R:R:P719	6.57	Yes	No	2	9	9
106	R:R:S645	R:R:W680	8.65	No	Yes	0	8	8
107	R:R:P683	R:R:S645	3.56	Yes	No	0	8	8
108	R:R:F647	R:R:F716	5.36	Yes	Yes	0	9	9
109	R:R:A720	R:R:F647	8.32	No	Yes	0	9	9
110	R:R:F647	R:R:W773	12.03	Yes	No	0	9	9
111	R:R:A648	R:R:P683	3.74	No	Yes	0	7	8
112	R:R:V652	R:R:W649	7.36	Yes	Yes	1	8	9
113	R:R:W649	R:R:Y676	3.86	Yes	No	1	9	8
114	R:R:G679	R:R:W649	7.04	No	Yes	0	9	9
115	R:R:W649	R:R:W680	13.12	Yes	Yes	1	9	8
116	R:R:M650	R:R:Q798	5.44	No	No	0	9	9
117	R:R:L651	R:R:M678	4.24	No	Yes	0	9	7
118	R:R:L651	R:R:V723	8.94	No	No	0	9	8
119	R:R:V652	R:R:Y675	7.57	Yes	Yes	1	8	8
120	R:R:M678	R:R:V652	3.04	Yes	Yes	0	7	8
121	R:R:E653	R:R:I768	13.66	No	No	1	9	8
122	R:R:L655	R:R:Y674	3.52	No	No	0	7	5
123	R:R:H656	R:R:M660	9.19	Yes	No	0	8	8
124	R:R:H656	R:R:Y675	10.89	Yes	Yes	1	8	8
125	R:R:L657	R:R:V734	7.45	No	No	0	9	9
126	R:R:L657	R:R:L765	4.15	No	Yes	0	9	9
127	R:R:I662	R:R:Y658	12.09	No	No	0	8	8
128	R:R:I730	R:R:Y658	7.25	No	No	0	8	8
129	R:R:K663	R:R:S659	3.06	No	No	0	7	8
130	R:R:K671	R:R:S659	4.59	Yes	No	0	8	8
131	R:R:M660	R:R:S667	3.07	No	No	0	8	8
132	R:R:V661	R:R:V734	3.21	No	No	0	9	9
133	R:R:A733	R:R:I662	3.25	No	No	0	8	8
134	R:R:F665	R:R:V664	7.87	No	No	0	8	9
135	R:R:D669	R:R:K671	5.53	No	Yes	0	6	8
136	R:R:H672	R:R:S670	5.58	No	No	0	7	7
137	R:R:K671	R:R:Y675	9.55	Yes	Yes	1	8	8
138	R:R:M678	R:R:Y674	11.97	Yes	No	0	7	5
139	R:R:F682	R:R:M678	4.98	No	Yes	0	4	7
140	R:R:I686	R:R:P719	5.08	No	No	2	7	9
141	R:R:S690	R:R:Y698	5.09	No	Yes	0	8	9
142	R:R:L691	R:R:M695	4.24	No	No	0	4	2
143	R:R:L691	R:R:Y698	4.69	No	Yes	2	4	9
144	R:R:S697	R:R:S707	3.26	Yes	Yes	6	7	8
145	R:R:S697	R:R:S710	3.26	Yes	No	6	7	4
146	R:R:A712	R:R:S697	3.42	No	Yes	0	7	7
147	R:R:L706	R:R:Y698	9.38	No	Yes	2	9	9
148	R:R:G699	R:R:T700	3.64	No	No	0	8	4
149	R:R:N702	R:R:N703	5.45	No	No	0	3	7
150	R:R:N703	R:R:W705	12.43	No	Yes	0	7	9
151	R:R:S707	R:R:S710	4.89	Yes	No	6	8	4
152	R:R:G711	R:R:S710	3.71	No	No	0	7	4
153	R:R:V717	R:R:W714	4.9	No	No	0	8	8
154	R:R:L721	R:R:V777	8.94	No	No	0	7	7
155	R:R:I730	R:R:V726	3.07	No	No	0	8	8
156	R:R:L769	R:R:N727	8.24	No	No	0	9	9
157	R:R:G729	R:R:I728	3.53	No	No	0	5	5
158	R:R:I728	R:R:T771	4.56	No	No	0	5	8
159	R:R:L731	R:R:L765	4.15	Yes	Yes	5	8	9
160	R:R:L731	R:R:L769	4.15	Yes	No	5	8	9
161	R:R:L731	R:R:T771	4.42	Yes	No	0	8	8
162	R:R:I732	R:R:T735	4.56	No	No	0	4	9
163	R:R:I741	R:R:V737	3.07	No	No	0	8	8
164	R:R:I738	R:R:T758	4.56	No	No	0	9	8
165	R:R:A761	R:R:I738	3.25	No	No	0	9	9
166	R:R:F805	R:R:V764	5.24	Yes	No	0	8	8
167	R:R:L765	R:R:L769	6.92	Yes	No	5	9	9
168	R:R:L766	R:R:T771	4.42	No	No	0	8	8
169	R:R:F801	R:R:P767	4.33	Yes	No	0	8	9
170	R:R:I802	R:R:P767	5.08	No	No	0	8	9
171	R:R:H806	R:R:P767	3.05	No	No	0	9	9
172	R:R:H806	R:R:I768	14.58	No	No	1	9	8
173	R:R:L794	R:R:S772	4.5	No	No	0	6	9
174	R:R:N795	R:R:S772	4.47	No	No	0	9	9
175	R:R:N795	R:R:W773	22.6	No	No	0	9	9
176	R:R:Q798	R:R:W773	6.57	No	No	0	9	9
177	R:R:F775	R:R:V774	3.93	No	No	0	8	5
178	R:R:F775	R:R:F787	4.29	No	No	0	8	7
179	R:R:F787	R:R:L778	6.09	No	No	0	7	7
180	R:R:F791	R:R:N795	9.67	No	No	0	9	9
181	R:R:F801	R:R:L797	4.87	Yes	No	0	8	7
182	R:R:L800	R:R:L804	4.15	No	No	0	6	8
183	R:R:F801	R:R:F805	3.22	Yes	Yes	0	8	8
184	R:R:C807	R:R:F803	5.59	Yes	Yes	1	8	9
185	R:R:F803	R:R:L808	8.53	Yes	No	0	9	7
186	R:R:F817	R:R:T821	5.19	No	No	0	7	8
187	R:R:H819	R:R:V823	6.92	No	No	0	8	7
188	R:R:K820	R:R:W824	6.96	No	No	0	8	7
189	R:R:L826	R:R:S825	4.5	No	No	0	8	8
190	R:R:F791	R:R:G776	3.01	No	No	0	9	9
191	R:R:G677	R:R:R673	3	No	No	0	5	3
192	R:R:L613	R:R:V578	2.98	Yes	No	4	8	7
193	R:R:L581	R:R:V612	2.98	Yes	No	0	9	8
194	R:R:L613	R:R:V582	2.98	Yes	No	0	8	4
195	R:R:L608	R:R:V612	2.98	No	No	0	9	8
196	R:R:L613	R:R:V617	2.98	Yes	No	4	8	5
197	R:R:L651	R:R:V726	2.98	No	No	0	9	8
198	R:R:L766	R:R:V762	2.98	No	No	0	8	8
199	R:R:L765	R:R:V764	2.98	Yes	No	0	9	8
200	R:R:L731	R:R:T735	2.95	Yes	No	0	8	9
201	R:R:A715	R:R:H640	2.93	No	Yes	0	9	9
202	R:R:E668	R:R:S667	2.87	No	No	0	8	8
203	R:R:L794	R:R:M790	2.83	No	No	0	6	5
204	R:R:K760	R:R:L757	2.82	No	No	0	9	8
205	R:R:H819	R:R:V594	2.77	No	No	0	8	8
206	R:R:A763	R:R:F805	2.77	No	Yes	0	7	8
207	R:R:L566	R:R:Q788	2.66	No	No	0	9	8
208	R:R:F623	R:R:S570	2.64	Yes	No	0	6	7
209	R:R:R814	R:R:S811	2.64	No	No	0	9	8
210	R:R:F722	R:R:V726	2.62	No	No	0	5	8
211	R:R:A611	R:R:W680	2.59	No	Yes	0	8	8
212	R:R:F647	R:R:I724	2.51	Yes	No	0	9	9
213	R:R:F693	R:R:I689	2.51	No	No	0	5	6
214	R:R:I732	R:R:R736	2.51	No	No	0	4	7
215	R:R:F775	R:R:L794	2.44	No	No	0	8	6
216	R:R:F801	R:R:L800	2.44	Yes	No	0	8	6
217	R:R:F805	R:R:L804	2.44	Yes	No	0	8	8
218	R:R:F623	R:R:R624	2.14	Yes	No	0	6	4
219	R:R:G677	R:R:G681	2.11	No	No	0	5	9
220	R:R:G628	R:R:P627	2.03	No	No	0	7	5
221	R:R:G681	R:R:P683	2.03	No	Yes	0	9	8
222	R:R:C632	R:R:P627	1.88	No	No	0	9	5
223	R:R:A718	R:R:P719	1.87	No	No	0	7	9
224	R:R:G573	R:R:S796	1.86	No	No	0	9	9
225	R:R:G573	R:R:V572	1.84	No	No	0	9	5
226	R:R:A611	R:R:A646	1.79	No	No	0	8	7
227	R:R:G654	R:R:I730	1.76	No	No	0	9	8
228	R:R:G770	R:R:M650	1.75	No	No	0	9	9
229	R:R:G666	R:R:K663	1.74	No	No	0	7	7
230	R:R:A694	R:R:S697	1.71	No	Yes	0	6	7
231	R:R:A709	R:R:S707	1.71	No	Yes	0	2	8
232	R:R:A754	R:R:S742	1.71	No	No	0	8	8
233	R:R:A792	R:R:S796	1.71	No	No	0	8	9
234	R:R:A565	R:R:I569	1.62	No	Yes	0	6	9
235	R:R:A792	R:R:I569	1.62	No	Yes	0	8	9
236	R:R:V582	R:R:V586	1.6	No	No	0	4	6
237	R:R:S595	R:R:T596	1.6	No	No	0	9	9
238	R:R:V661	R:R:V737	1.6	No	No	0	9	8
239	R:R:S707	R:R:T700	1.6	Yes	No	0	8	4
240	R:R:S739	R:R:T758	1.6	No	No	0	8	8
241	R:R:C632	R:R:L625	1.59	No	No	0	9	4
242	R:R:T827	R:R:V823	1.59	No	No	0	8	7
243	R:R:A606	R:R:L585	1.58	No	No	0	7	7
244	R:R:A779	R:R:L778	1.58	No	No	0	8	7
245	R:R:E626	R:R:P627	1.57	No	No	0	2	5
246	R:R:T735	R:R:T758	1.57	No	No	0	9	8
247	R:R:I688	R:R:S692	1.55	No	No	0	4	6
248	R:R:I621	R:R:V617	1.54	No	No	0	4	5
249	R:R:I724	R:R:V777	1.54	No	No	0	9	7
250	R:R:K756	R:R:S753	1.53	No	No	0	6	6
251	R:R:I569	R:R:T793	1.52	Yes	No	0	9	5
252	R:R:K760	R:R:V764	1.52	No	No	0	9	8
253	R:R:F665	R:R:G666	1.51	No	No	0	8	7
254	R:R:L620	R:R:S575	1.5	No	No	0	8	7
255	R:R:L757	R:R:S753	1.5	No	No	0	8	6
256	R:R:K818	R:R:T821	1.5	No	No	0	8	8
257	R:R:L579	R:R:V578	1.49	No	No	0	4	7
258	R:R:D696	R:R:S697	1.47	No	Yes	0	3	7
259	R:R:K818	R:R:K822	1.44	No	No	0	8	8
260	R:R:I688	R:R:L684	1.43	No	No	0	4	5
261	R:R:G711	R:R:W714	1.41	No	No	0	7	8
262	R:R:A754	R:R:F755	1.39	No	No	0	8	6
263	R:R:L808	R:R:L809	1.38	No	No	0	7	8
264	R:R:R598	R:R:S592	1.32	No	No	0	7	8
265	R:R:F787	R:R:V786	1.31	No	No	0	7	5
266	R:R:S575	R:R:Y571	1.27	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.9829	7	2	0
2	R:R:I569	2.35	4	0	9
3	R:R:L581	4.5175	4	0	9
4	R:R:T584	5.6175	4	1	9
5	R:R:Q600	10.525	4	1	8
6	R:R:R601	7.13	4	1	8
7	R:R:Y602	7.30875	8	1	8
8	R:R:I604	6.61	5	1	9
9	R:R:H605	7.448	5	1	9
10	R:R:L613	3.62	4	4	8
11	R:R:F623	4.9375	4	2	6
12	R:R:H640	6.44	7	2	9
13	R:R:L644	5.886	5	2	9
14	R:R:F647	7.055	4	0	9
15	R:R:W649	8.72286	7	1	9
16	R:R:V652	6.0275	4	1	8
17	R:R:H656	7.238	5	1	8
18	R:R:K671	6.9525	4	1	8
19	R:R:Y675	7.68	5	1	8
20	R:R:M678	6.0575	4	0	7
21	R:R:W680	7.46667	6	1	8
22	R:R:P683	3.356	5	0	8
23	R:R:S697	2.624	5	6	7
24	R:R:Y698	5.65	7	2	9
25	R:R:W705	9.32	5	2	9
26	R:R:S707	2.865	4	6	8
27	R:R:F716	8.135	4	2	9
28	R:R:L731	3.9175	4	5	8
29	R:R:L765	4.55	4	5	9
30	R:R:F801	3.715	4	0	8
31	R:R:F803	6.91	5	1	9
32	R:R:F805	3.4175	4	0	8
33	R:R:C807	5.6775	4	1	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L619	22.5023	8.83	Yes	No	2	0	9
2	R:R:F623	R:R:L619	21.216	10.96	Yes	No	2	6	9
3	R:R:F623	R:R:S570	36.9752	2.64	Yes	No	0	6	7
4	R:R:S570	R:R:S796	34.3958	3.26	No	No	0	7	9
5	R:R:A792	R:R:S796	25.056	1.71	No	No	0	8	9
6	R:R:A792	R:R:I569	21.9341	1.62	No	Yes	0	8	9
7	R:R:A565	R:R:I569	12.5529	1.62	No	Yes	0	6	9
8	L:L:?1	R:R:W705	27.5459	21.8	Yes	Yes	2	0	9
9	R:R:F623	R:R:W705	21.6965	4.01	Yes	Yes	2	6	9
10	L:L:?1	R:R:H640	34.3217	5.86	Yes	Yes	2	0	9
11	R:R:H640	R:R:L644	48.3056	9	Yes	Yes	2	9	9
12	R:R:L644	R:R:P683	96.7094	3.28	Yes	Yes	0	9	8
13	R:R:P683	R:R:Y641	49.864	4.17	Yes	No	0	8	7
14	R:R:W680	R:R:Y641	50.3599	9.65	Yes	No	0	8	7
15	R:R:W649	R:R:W680	100	13.12	Yes	Yes	1	9	8
16	R:R:L608	R:R:W649	16.0519	3.42	No	Yes	0	9	9
17	R:R:L608	R:R:V612	15.2788	2.98	No	No	0	9	8
18	L:L:?1	R:R:F716	33.0664	16.65	Yes	Yes	2	0	9
19	R:R:F716	R:R:L644	46.5527	4.87	Yes	Yes	2	9	9
20	R:R:P683	R:R:S645	49.1304	3.56	Yes	No	0	8	8
21	R:R:S645	R:R:W680	49.2544	8.65	No	Yes	0	8	8
22	R:R:I604	R:R:W649	74.1175	7.05	Yes	Yes	1	9	9
23	R:R:E653	R:R:I604	56.3867	10.93	No	Yes	1	9	9
24	R:R:E653	R:R:H605	33.5589	13.54	No	Yes	1	9	9
25	R:R:H605	R:R:H806	26.2148	11.94	Yes	No	1	9	9
26	R:R:H806	R:R:P767	46.7524	3.05	No	No	0	9	9
27	R:R:F801	R:R:P767	44.1988	4.33	Yes	No	0	8	9
28	R:R:E653	R:R:I768	22.3835	13.66	No	No	1	9	8
29	R:R:H806	R:R:I768	21.8084	14.58	No	No	1	9	8
30	R:R:L581	R:R:V612	10.5056	2.98	Yes	No	0	9	8
31	R:R:H605	R:R:Y602	14.0838	3.27	Yes	Yes	1	9	8
32	R:R:H656	R:R:I604	16.3757	5.3	Yes	Yes	1	8	9
33	R:R:H656	R:R:R601	16.7872	3.39	Yes	Yes	1	8	8
34	R:R:R601	R:R:Y602	12.8646	11.32	Yes	Yes	1	8	8
35	R:R:I597	R:R:Y602	19.8247	14.51	No	Yes	1	8	8
36	R:R:A816	R:R:I597	13.2917	3.25	No	No	1	8	8
37	R:R:A816	R:R:L591	12.0226	4.73	No	No	0	8	8
38	R:R:K671	R:R:Y675	10.02	9.55	Yes	Yes	1	8	8
39	R:R:V652	R:R:W649	13.3864	7.36	Yes	Yes	1	8	9
40	R:R:H640	R:R:Y698	15.8246	5.44	Yes	Yes	2	9	9
41	R:R:Q633	R:R:Y698	12.6236	3.38	No	Yes	0	5	9
42	R:R:G699	R:R:Q633	11.673	4.93	No	No	0	8	5
43	R:R:F647	R:R:F716	14.8311	5.36	Yes	Yes	0	9	9
44	R:R:F647	R:R:W773	10.8431	12.03	Yes	No	0	9	9
45	L:L:?1	R:R:F791	19.42	7.77	Yes	No	0	0	9
46	R:R:F791	R:R:N795	16.5186	9.67	No	No	0	9	9
47	R:R:M678	R:R:V652	11.5043	3.04	Yes	Yes	0	7	8
48	R:R:F801	R:R:F805	37.6967	3.22	Yes	Yes	0	8	8
49	R:R:F805	R:R:V764	34.0428	5.24	Yes	No	0	8	8
50	R:R:L765	R:R:V764	27.6199	2.98	Yes	No	0	9	8
51	R:R:G699	R:R:T700	10.7191	3.64	No	No	0	8	4
52	R:R:L731	R:R:L765	17.1591	4.15	Yes	Yes	5	8	9
53	R:R:N795	R:R:S772	21.2453	4.47	No	No	0	9	9
54	R:R:L794	R:R:S772	18.8983	4.5	No	No	0	6	9
55	R:R:F775	R:R:L794	14.194	2.44	No	No	0	8	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L619	8.83	2	Yes	No	0	9	0	1
L:L:?1	R:R:H640	5.86	2	Yes	Yes	0	9	0	1
L:L:?1	R:R:W705	21.8	2	Yes	Yes	0	9	0	1
L:L:?1	R:R:L706	13.87	2	Yes	No	0	9	0	1
L:L:?1	R:R:I713	9.1	2	Yes	No	0	8	0	1
L:L:?1	R:R:F716	16.65	2	Yes	Yes	0	9	0	1
L:L:?1	R:R:F791	7.77	2	Yes	No	0	9	0	1
R:R:F623	R:R:L619	10.96	2	Yes	No	6	9	2	1
R:R:L619	R:R:W705	3.42	2	No	Yes	9	9	1	1
R:R:S622	R:R:W705	4.94	0	No	Yes	8	9	2	1
R:R:F623	R:R:W705	4.01	2	Yes	Yes	6	9	2	1
R:R:H640	R:R:L644	9	2	Yes	Yes	9	9	1	2
R:R:C687	R:R:H640	5.9	0	No	Yes	8	9	2	1
R:R:H640	R:R:Y698	5.44	2	Yes	Yes	9	9	1	2
R:R:H640	R:R:L706	10.29	2	Yes	No	9	9	1	1
R:R:F716	R:R:H640	5.66	2	Yes	Yes	9	9	1	1
R:R:F716	R:R:L644	4.87	2	Yes	Yes	9	9	1	2
R:R:F647	R:R:F716	5.36	0	Yes	Yes	9	9	2	1
R:R:L706	R:R:Y698	9.38	2	No	Yes	9	9	1	2
R:R:N703	R:R:W705	12.43	0	No	Yes	7	9	2	1
R:R:F791	R:R:N795	9.67	0	No	No	9	9	1	2
R:R:F791	R:R:G776	3.01	0	No	No	9	9	1	2
R:R:A715	R:R:H640	2.93	0	No	Yes	9	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8X9U_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	239
Number of Links	266
Number of Hubs	33
Number of Links mediated by Hubs	124
Number of Communities	6
Number of Nodes involved in Communities	50
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	80636
Length Of Smallest Path	3
Average Path Length	15.9067
Length of Longest Path	31
Minimum Path Strength	1.385
Average Path Strength	6.57176
Maximum Path Strength	19.225
Minimum Path Correlation	0.7
Average Path Correlation	0.921739
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	37.7691
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.6048
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q6QNK2
Sequence	>8X9U_nogp_Chain_R H Q V A L S S I S Y V G C S L S V L C L V A T L V T F A V L S S V S T I R N Q R Y H I H A N L S F A V L V A Q V L L L I S F R L E P G T T P C Q V M A V L L H Y F F L S A F A W M L V E G L H L Y S M V I K V F G S E D S K H R Y Y Y G M G W G F P L L I C I I S L S F A M D S Y G T S N N C W L S L A S G A I W A F V A P A L F V I V V N I G I L I A V T R V I S Q I S A D S A F K L T A K A V A V L L P I L G T S W V F G V L A V F Q Y M F A T L N S L Q G L F I F L F H C L L N S E V R A A F K H K T K V W S L T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9V0U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9V0U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8X9U_nogp.zip

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