psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F623	R:R:T545	7.78	No	No	0	6	9
2	R:R:N546	R:R:Q563	10.56	No	No	0	9	4
3	R:R:L566	R:R:N546	4.12	Yes	No	0	9	9
4	R:R:N546	R:R:Q788	3.96	No	Yes	0	9	8
5	R:R:F547	R:R:S570	6.61	No	No	0	9	7
6	R:R:A792	R:R:F547	4.16	No	No	0	8	9
7	R:R:F547	R:R:S796	3.96	No	No	0	9	9
8	R:R:A548	R:R:Q788	4.55	No	Yes	0	9	8
9	R:R:I549	R:R:N703	11.33	No	Yes	1	8	7
10	R:R:I549	R:R:W705	7.05	No	Yes	1	8	9
11	R:R:L550	R:R:L619	4.15	Yes	No	0	9	9
12	R:R:F643	R:R:L550	8.53	No	Yes	1	8	9
13	R:R:L550	R:R:W705	9.11	Yes	Yes	1	9	9
14	R:R:L550	R:R:W773	3.42	Yes	Yes	1	9	9
15	R:R:M551	R:R:W773	3.49	No	Yes	1	9	9
16	R:R:F791	R:R:M551	4.98	Yes	No	1	9	9
17	R:R:Q552	R:R:Q788	5.12	No	Yes	0	9	8
18	R:R:V553	R:R:W714	6.13	No	No	1	8	8
19	R:R:V553	R:R:V717	3.21	No	No	1	8	8
20	R:R:P555	R:R:V554	3.53	No	No	0	6	8
21	R:R:V554	R:R:V780	4.81	No	No	0	8	7
22	R:R:L556	R:R:L558	4.15	No	No	0	4	5
23	R:R:L558	R:R:Q563	7.99	No	No	0	5	4
24	R:R:L558	R:R:Q788	3.99	No	Yes	0	5	8
25	R:R:A559	R:R:H562	2.93	No	No	0	3	7
26	R:R:H562	R:R:Y789	8.71	No	No	0	7	9
27	R:R:I569	R:R:L566	2.85	No	Yes	0	9	9
28	R:R:L566	R:R:S570	3	Yes	No	0	9	7
29	R:R:L566	R:R:Y789	10.55	Yes	No	0	9	9
30	R:R:A792	R:R:L566	3.15	No	Yes	0	8	9
31	R:R:S567	R:R:Y571	12.72	No	No	0	7	7
32	R:R:I569	R:R:S568	3.1	No	No	0	9	5
33	R:R:F623	R:R:Y571	11.35	No	No	0	6	7
34	R:R:S575	R:R:V572	3.23	No	No	0	7	5
35	R:R:G573	R:R:S796	3.71	No	No	0	9	9
36	R:R:C574	R:R:L620	4.76	No	No	0	8	8
37	R:R:C574	R:R:S796	5.16	No	No	0	8	9
38	R:R:L581	R:R:S577	3	Yes	No	5	9	9
39	R:R:Q616	R:R:S577	8.66	No	No	0	8	9
40	R:R:G799	R:R:S577	3.71	No	No	5	8	9
41	R:R:Q616	R:R:V578	2.87	No	No	0	8	7
42	R:R:V578	R:R:V617	3.21	No	No	0	7	5
43	R:R:C580	R:R:L800	4.76	No	No	0	7	6
44	R:R:C580	R:R:F803	6.98	No	Yes	0	7	9
45	R:R:L581	R:R:V612	2.98	Yes	Yes	0	9	8
46	R:R:L581	R:R:L613	5.54	Yes	No	0	9	8
47	R:R:G799	R:R:L581	5.13	No	Yes	5	8	9
48	R:R:L613	R:R:V582	2.98	No	No	0	8	4
49	R:R:A583	R:R:F803	4.16	No	Yes	0	6	9
50	R:R:F588	R:R:T584	3.89	No	No	0	7	9
51	R:R:F803	R:R:T584	6.49	Yes	No	6	9	9
52	R:R:C807	R:R:T584	6.76	No	No	6	8	9
53	R:R:L585	R:R:S609	3	No	No	0	7	8
54	R:R:F610	R:R:L585	4.87	No	No	0	4	7
55	R:R:F588	R:R:Y602	6.19	No	Yes	0	7	8
56	R:R:I597	R:R:L591	2.85	No	No	0	8	8
57	R:R:K820	R:R:S593	3.06	No	No	0	8	8
58	R:R:T596	R:R:V594	3.17	No	Yes	0	9	8
59	R:R:I597	R:R:V594	4.61	No	Yes	0	8	8
60	R:R:E812	R:R:T596	4.23	No	No	0	8	9
61	R:R:I597	R:R:Y602	9.67	No	Yes	0	8	8
62	R:R:H603	R:R:R598	4.51	No	No	0	8	7
63	R:R:H672	R:R:Q600	14.84	No	No	0	7	8
64	R:R:R601	R:R:Y602	4.12	Yes	Yes	3	8	8
65	R:R:H656	R:R:R601	5.64	No	Yes	0	8	8
66	R:R:M660	R:R:R601	6.2	No	Yes	0	8	8
67	R:R:E812	R:R:R601	5.82	No	Yes	3	8	8
68	R:R:N810	R:R:Y602	3.49	No	Yes	3	9	8
69	R:R:E812	R:R:Y602	11.22	No	Yes	3	8	8
70	R:R:V813	R:R:Y602	3.79	No	Yes	3	9	8
71	R:R:H603	R:R:H672	3.58	No	No	0	8	7
72	R:R:I604	R:R:W649	4.7	Yes	Yes	2	9	9
73	R:R:I604	R:R:V652	6.14	Yes	Yes	2	9	8
74	R:R:E653	R:R:I604	5.47	Yes	Yes	0	9	9
75	R:R:I604	R:R:Y675	4.84	Yes	Yes	2	9	8
76	R:R:E653	R:R:H605	19.69	Yes	No	0	9	9
77	R:R:H605	R:R:H806	9.55	No	Yes	0	9	9
78	R:R:N607	R:R:W649	16.95	No	Yes	2	9	9
79	R:R:N607	R:R:Y676	11.63	No	No	2	9	8
80	R:R:L608	R:R:V612	2.98	No	Yes	0	9	8
81	R:R:L608	R:R:W649	4.56	No	Yes	0	9	9
82	R:R:E653	R:R:L608	5.3	Yes	No	0	9	9
83	R:R:F610	R:R:V614	7.87	No	No	0	4	6
84	R:R:Q616	R:R:V612	5.73	No	Yes	0	8	8
85	R:R:Q798	R:R:V612	2.87	No	Yes	0	9	8
86	R:R:L618	R:R:V614	2.98	No	No	2	7	6
87	R:R:F642	R:R:V614	13.11	Yes	No	2	8	6
88	R:R:A615	R:R:F643	8.32	No	No	0	9	8
89	R:R:L618	R:R:L638	4.15	No	No	2	7	7
90	R:R:F642	R:R:L618	3.65	Yes	No	2	8	7
91	R:R:F623	R:R:L619	8.53	No	No	0	6	9
92	R:R:L619	R:R:L639	4.15	No	No	0	9	9
93	R:R:M635	R:R:S622	6.13	No	No	4	6	8
94	R:R:L639	R:R:S622	3	No	No	0	9	8
95	R:R:C704	R:R:S622	3.44	Yes	No	4	9	8
96	R:R:E626	R:R:P627	7.86	No	No	0	2	5
97	R:R:P631	R:R:T629	5.25	No	No	0	6	8
98	R:R:P631	R:R:T630	5.25	No	No	0	6	3
99	R:R:C632	R:R:C704	7.28	No	Yes	4	9	9
100	R:R:Q633	R:R:Y698	3.38	No	Yes	0	5	9
101	R:R:C704	R:R:M635	4.86	Yes	No	4	9	6
102	R:R:V637	R:R:Y698	13.88	No	Yes	0	4	9
103	R:R:F642	R:R:L638	4.87	Yes	No	2	8	7
104	R:R:L639	R:R:W705	3.42	No	Yes	0	9	9
105	R:R:H640	R:R:L644	9	Yes	Yes	1	9	9
106	R:R:C687	R:R:H640	4.42	No	Yes	0	8	9
107	R:R:H640	R:R:Y698	9.8	Yes	Yes	1	9	9
108	R:R:H640	R:R:W705	3.17	Yes	Yes	1	9	9
109	R:R:H640	R:R:L706	7.71	Yes	Yes	1	9	9
110	R:R:F716	R:R:H640	7.92	No	Yes	1	9	9
111	R:R:F642	R:R:Y641	4.13	Yes	Yes	2	8	7
112	R:R:S645	R:R:Y641	6.36	No	Yes	2	8	7
113	R:R:W680	R:R:Y641	4.82	Yes	Yes	2	8	7
114	R:R:L684	R:R:Y641	4.69	No	Yes	0	5	7
115	R:R:F643	R:R:W705	3.01	No	Yes	1	8	9
116	R:R:L644	R:R:P683	3.28	Yes	Yes	0	9	8
117	R:R:F716	R:R:L644	6.09	No	Yes	1	9	9
118	R:R:S645	R:R:W680	7.41	No	Yes	2	8	8
119	R:R:P683	R:R:S645	7.13	Yes	No	0	8	8
120	R:R:A720	R:R:F647	8.32	No	No	0	9	9
121	R:R:F647	R:R:I724	5.02	No	No	0	9	9
122	R:R:F647	R:R:W773	18.04	No	Yes	0	9	9
123	R:R:A648	R:R:P683	3.74	No	Yes	0	7	8
124	R:R:V652	R:R:W649	7.36	Yes	Yes	2	8	9
125	R:R:W649	R:R:Y676	2.89	Yes	No	2	9	8
126	R:R:G679	R:R:W649	11.26	No	Yes	0	9	9
127	R:R:W649	R:R:W680	18.74	Yes	Yes	2	9	8
128	R:R:G770	R:R:M650	3.49	No	No	0	9	9
129	R:R:M650	R:R:Q798	4.08	No	No	0	9	9
130	R:R:L651	R:R:V723	7.45	No	No	0	9	8
131	R:R:V652	R:R:Y675	6.31	Yes	Yes	2	8	8
132	R:R:M678	R:R:V652	4.56	Yes	Yes	0	7	8
133	R:R:E653	R:R:I768	10.93	Yes	No	0	9	8
134	R:R:G654	R:R:N727	3.39	No	No	0	9	9
135	R:R:H656	R:R:Y675	9.8	No	Yes	0	8	8
136	R:R:L657	R:R:V661	2.98	No	No	0	9	9
137	R:R:L657	R:R:V734	4.47	No	No	7	9	9
138	R:R:L657	R:R:L765	4.15	No	Yes	7	9	9
139	R:R:I662	R:R:Y658	13.3	Yes	No	0	8	8
140	R:R:I730	R:R:Y658	8.46	No	No	0	8	8
141	R:R:M660	R:R:S667	7.67	No	No	0	8	8
142	R:R:I662	R:R:V661	3.07	Yes	No	0	8	9
143	R:R:I662	R:R:V737	4.61	Yes	No	0	8	8
144	R:R:F665	R:R:V664	3.93	No	No	0	8	9
145	R:R:D669	R:R:G666	3.35	No	No	0	6	7
146	R:R:K671	R:R:Y675	10.75	No	Yes	0	8	8
147	R:R:W680	R:R:Y676	3.86	Yes	No	2	8	8
148	R:R:F682	R:R:M678	4.98	No	Yes	0	4	7
149	R:R:S690	R:R:Y698	6.36	No	Yes	0	8	9
150	R:R:A694	R:R:S697	3.42	No	Yes	0	6	7
151	R:R:D696	R:R:S697	2.94	No	Yes	0	3	7
152	R:R:S697	R:R:S707	3.26	Yes	No	8	7	8
153	R:R:S697	R:R:S710	3.26	Yes	No	8	7	4
154	R:R:A712	R:R:S697	3.42	No	Yes	0	7	7
155	R:R:L706	R:R:Y698	8.21	Yes	Yes	1	9	9
156	R:R:S707	R:R:T700	7.99	No	No	0	8	4
157	R:R:N702	R:R:S701	4.47	No	No	1	3	3
158	R:R:N703	R:R:S701	4.47	Yes	No	1	7	3
159	R:R:N702	R:R:N703	4.09	No	Yes	1	3	7
160	R:R:N703	R:R:W705	5.65	Yes	Yes	1	7	9
161	R:R:L706	R:R:W705	4.56	Yes	Yes	1	9	9
162	R:R:I713	R:R:W705	3.52	Yes	Yes	1	8	9
163	R:R:F716	R:R:W705	5.01	No	Yes	1	9	9
164	R:R:I713	R:R:L706	2.85	Yes	Yes	1	8	9
165	R:R:S707	R:R:S710	4.89	No	No	8	8	4
166	R:R:V717	R:R:W714	7.36	No	No	1	8	8
167	R:R:L721	R:R:V725	2.98	No	No	0	7	4
168	R:R:F722	R:R:V726	3.93	No	No	0	5	8
169	R:R:I724	R:R:I728	2.94	No	No	0	9	5
170	R:R:I724	R:R:V774	4.61	No	No	0	9	5
171	R:R:L769	R:R:N727	13.73	No	No	0	9	9
172	R:R:G729	R:R:I728	3.53	No	No	0	5	5
173	R:R:I728	R:R:T771	4.56	No	No	0	5	8
174	R:R:L731	R:R:L765	4.15	No	Yes	0	8	9
175	R:R:L731	R:R:L769	5.54	No	No	0	8	9
176	R:R:I738	R:R:V734	3.07	Yes	No	0	9	9
177	R:R:L765	R:R:V734	2.98	Yes	No	7	9	9
178	R:R:A761	R:R:I738	3.25	No	Yes	0	9	9
179	R:R:S739	R:R:T758	3.2	No	Yes	0	8	8
180	R:R:S742	R:R:T758	3.2	No	Yes	0	8	8
181	R:R:D744	R:R:K747	6.91	No	No	0	6	6
182	R:R:G750	R:R:Y746	4.35	No	No	0	5	6
183	R:R:D751	R:R:P752	8.05	No	No	0	6	5
184	R:R:D751	R:R:S753	5.89	No	No	0	6	6
185	R:R:K756	R:R:S753	3.06	No	No	0	6	6
186	R:R:F805	R:R:V764	6.55	No	No	0	8	8
187	R:R:I768	R:R:L765	2.85	No	Yes	0	8	9
188	R:R:F801	R:R:P767	2.89	No	No	0	8	9
189	R:R:H806	R:R:I768	3.98	Yes	No	0	9	8
190	R:R:L794	R:R:S772	6.01	No	No	0	6	9
191	R:R:N795	R:R:S772	4.47	No	No	0	9	9
192	R:R:F791	R:R:W773	8.02	Yes	Yes	1	9	9
193	R:R:N795	R:R:W773	24.86	No	Yes	1	9	9
194	R:R:Q798	R:R:W773	4.38	No	Yes	0	9	9
195	R:R:F775	R:R:F791	3.22	No	Yes	0	8	9
196	R:R:F791	R:R:G776	6.02	Yes	No	0	9	9
197	R:R:F787	R:R:L778	4.87	No	No	0	7	7
198	R:R:G782	R:R:N781	5.09	No	No	0	3	7
199	R:R:F787	R:R:N781	3.62	No	No	0	7	7
200	R:R:V785	R:R:Y789	6.31	No	No	0	5	9
201	R:R:M790	R:R:V786	4.56	No	No	0	5	5
202	R:R:F791	R:R:N795	12.08	Yes	No	1	9	9
203	R:R:L794	R:R:T793	2.95	No	No	0	6	5
204	R:R:L797	R:R:T793	2.95	No	No	0	7	5
205	R:R:F801	R:R:L797	6.09	No	No	0	8	7
206	R:R:H806	R:R:I802	6.63	Yes	No	0	9	8
207	R:R:C807	R:R:F803	4.19	No	Yes	6	8	9
208	R:R:F803	R:R:L808	9.74	Yes	No	0	9	7
209	R:R:F805	R:R:L804	4.87	No	No	0	8	8
210	R:R:L804	R:R:L809	5.54	No	No	0	8	8
211	R:R:N810	R:R:V813	7.39	No	No	3	9	9
212	R:R:F817	R:R:T821	3.89	No	No	0	7	8
213	R:R:L651	R:R:M678	2.83	No	Yes	0	9	7
214	R:R:L655	R:R:M678	2.83	No	Yes	0	7	7
215	R:R:A548	R:R:F791	2.77	No	Yes	0	9	9
216	R:R:A606	R:R:F588	2.77	No	No	0	7	7
217	R:R:A733	R:R:R736	2.77	No	No	0	8	7
218	R:R:A636	R:R:Y698	2.67	No	Yes	0	9	9
219	R:R:F693	R:R:S692	2.64	No	No	0	5	6
220	R:R:R814	R:R:S811	2.64	No	No	0	9	8
221	R:R:F787	R:R:V786	2.62	No	No	0	7	5
222	R:R:F775	R:R:M790	2.49	No	No	0	8	5
223	R:R:F817	R:R:L591	2.44	No	No	0	7	8
224	R:R:L691	R:R:Y698	2.34	No	Yes	0	4	9
225	R:R:N599	R:R:Y602	2.33	No	Yes	0	8	8
226	R:R:F805	R:R:H806	2.26	No	Yes	0	8	9
227	R:R:Q600	R:R:Y675	2.25	No	Yes	0	8	8
228	R:R:G681	R:R:P683	2.03	No	Yes	0	9	8
229	R:R:A718	R:R:P719	1.87	No	No	0	7	9
230	R:R:G561	R:R:V564	1.84	No	No	0	2	5
231	R:R:G573	R:R:V572	1.84	No	No	0	9	5
232	R:R:A611	R:R:A646	1.79	No	No	0	8	7
233	R:R:A715	R:R:S690	1.71	No	No	0	9	8
234	R:R:A754	R:R:S742	1.71	No	No	0	8	8
235	R:R:C783	R:R:V786	1.71	No	No	0	4	5
236	R:R:A779	R:R:V554	1.7	No	No	0	8	8
237	R:R:A816	R:R:V594	1.7	No	Yes	0	8	8
238	R:R:A646	R:R:V612	1.7	No	Yes	0	7	8
239	R:R:C632	R:R:T629	1.69	No	No	0	9	8
240	R:R:L708	R:R:P555	1.64	No	No	0	7	6
241	R:R:L644	R:R:P719	1.64	Yes	No	0	9	9
242	R:R:L766	R:R:P767	1.64	No	No	0	8	9
243	R:R:S593	R:R:V594	1.62	No	Yes	0	8	8
244	R:R:A733	R:R:I662	1.62	No	Yes	0	8	8
245	R:R:V582	R:R:V586	1.6	No	No	0	4	6
246	R:R:T587	R:R:V586	1.59	No	No	0	8	6
247	R:R:C632	R:R:L625	1.59	No	No	4	9	4
248	R:R:C704	R:R:L625	1.59	Yes	No	4	9	4
249	R:R:T735	R:R:V762	1.59	No	No	0	9	8
250	R:R:A784	R:R:L556	1.58	No	No	0	6	4
251	R:R:A712	R:R:L706	1.58	No	Yes	0	7	9
252	R:R:T735	R:R:T758	1.57	No	Yes	0	9	8
253	R:R:I713	R:R:V553	1.54	Yes	No	1	8	8
254	R:R:I621	R:R:V617	1.54	No	No	0	4	5
255	R:R:I713	R:R:V717	1.54	Yes	No	1	8	8
256	R:R:I730	R:R:V726	1.54	No	No	0	8	8
257	R:R:A754	R:R:D751	1.54	No	No	0	8	6
258	R:R:K663	R:R:S659	1.53	No	No	0	7	8
259	R:R:M551	R:R:V777	1.52	No	No	0	9	7
260	R:R:I738	R:R:T758	1.52	Yes	Yes	0	9	8
261	R:R:A779	R:R:Q788	1.52	No	Yes	0	8	8
262	R:R:G561	R:R:R560	1.5	No	No	0	2	1
263	R:R:L576	R:R:S575	1.5	No	No	0	5	7
264	R:R:K818	R:R:T821	1.5	No	No	0	8	8
265	R:R:L579	R:R:V578	1.49	No	No	0	4	7
266	R:R:L591	R:R:V590	1.49	No	No	0	8	4
267	R:R:L721	R:R:V774	1.49	No	No	0	7	5
268	R:R:L721	R:R:V777	1.49	No	No	0	7	7
269	R:R:Q740	R:R:S739	1.44	No	No	0	8	8
270	R:R:I686	R:R:L644	1.43	No	Yes	0	7	9
271	R:R:I688	R:R:L684	1.43	No	No	0	4	5
272	R:R:I688	R:R:L691	1.43	No	No	0	4	4
273	R:R:I738	R:R:L757	1.43	Yes	No	0	9	8
274	R:R:I748	R:R:N745	1.42	No	No	0	6	6
275	R:R:E626	R:R:T629	1.41	No	No	0	2	8
276	R:R:K760	R:R:L809	1.41	No	No	0	9	8
277	R:R:H819	R:R:V594	1.38	No	Yes	0	8	8
278	R:R:D669	R:R:K671	1.38	No	No	0	6	8
279	R:R:D744	R:R:N745	1.35	No	No	0	6	6
280	R:R:F693	R:R:I689	1.26	No	No	0	5	6
281	R:R:I732	R:R:R736	1.25	No	No	0	4	7
282	R:R:K818	R:R:R814	1.24	No	No	0	8	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L550	6.3025	4	1	9
2	R:R:L566	4.734	5	0	9
3	R:R:L581	4.1625	4	5	9
4	R:R:V594	2.496	5	0	8
5	R:R:R601	5.445	4	3	8
6	R:R:Y602	5.83	7	3	8
7	R:R:I604	5.2875	4	2	9
8	R:R:V612	3.252	5	0	8
9	R:R:H640	7.00333	6	1	9
10	R:R:Y641	5	4	2	7
11	R:R:F642	6.44	4	2	8
12	R:R:L644	4.288	5	1	9
13	R:R:W649	9.49429	7	2	9
14	R:R:V652	6.0925	4	2	8
15	R:R:E653	10.3475	4	0	9
16	R:R:I662	5.65	4	0	8
17	R:R:Y675	6.79	5	2	8
18	R:R:M678	3.8	4	0	7
19	R:R:W680	8.7075	4	2	8
20	R:R:P683	4.045	4	0	8
21	R:R:S697	3.26	5	8	7
22	R:R:Y698	6.66286	7	1	9
23	R:R:N703	6.385	4	1	7
24	R:R:C704	4.2925	4	4	9
25	R:R:W705	4.94444	9	1	9
26	R:R:L706	4.982	5	1	9
27	R:R:I713	2.3625	4	1	8
28	R:R:I738	2.3175	4	0	9
29	R:R:T758	2.3725	4	0	8
30	R:R:L765	3.5325	4	7	9
31	R:R:W773	10.3683	6	1	9
32	R:R:Q788	3.828	5	0	8
33	R:R:F791	6.18167	6	1	9
34	R:R:F803	6.312	5	6	9
35	R:R:H806	5.605	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L550	R:R:L619	17.7822	4.15	Yes	No	0	9	9
2	R:R:L550	R:R:W773	58.8893	3.42	Yes	Yes	1	9	9
3	R:R:F791	R:R:W773	58.0028	8.02	Yes	Yes	1	9	9
4	R:R:A548	R:R:F791	49.458	2.77	No	Yes	0	9	9
5	R:R:A548	R:R:Q788	48.3257	4.55	No	Yes	0	9	8
6	R:R:N546	R:R:Q788	35.4863	3.96	No	Yes	0	9	8
7	R:R:L566	R:R:N546	33.3333	4.12	Yes	No	0	9	9
8	R:R:F547	R:R:S570	10.9062	6.61	No	No	0	9	7
9	R:R:L566	R:R:S570	12.236	3	Yes	No	0	9	7
10	R:R:A792	R:R:F547	10.9062	4.16	No	No	0	8	9
11	R:R:A792	R:R:L566	12.236	3.15	No	Yes	0	8	9
12	R:R:F547	R:R:S796	19.1083	3.96	No	No	0	9	9
13	R:R:L550	R:R:W705	41.0288	9.11	Yes	Yes	1	9	9
14	R:R:L619	R:R:L639	12.9623	4.15	No	No	0	9	9
15	R:R:L639	R:R:W705	23.7382	3.42	No	Yes	0	9	9
16	R:R:G573	R:R:S796	10.9621	3.71	No	No	0	9	9
17	R:R:Q798	R:R:W773	94.9082	4.38	No	Yes	0	9	9
18	R:R:Q798	R:R:V612	95.7686	2.87	No	Yes	0	9	8
19	R:R:F803	R:R:T584	12.1019	6.49	Yes	No	6	9	9
20	R:R:F588	R:R:T584	17.0224	3.89	No	No	0	7	9
21	R:R:F588	R:R:Y602	21.8944	6.19	No	Yes	0	7	8
22	R:R:R601	R:R:Y602	60.9081	4.12	Yes	Yes	3	8	8
23	R:R:H656	R:R:R601	83.5922	5.64	No	Yes	0	8	8
24	R:R:H656	R:R:Y675	85.7712	9.8	No	Yes	0	8	8
25	R:R:I604	R:R:Y675	65.6423	4.84	Yes	Yes	2	9	8
26	R:R:I604	R:R:W649	44.1167	4.7	Yes	Yes	2	9	9
27	R:R:L608	R:R:W649	58.7179	4.56	No	Yes	0	9	9
28	R:R:L608	R:R:V612	100	2.98	No	Yes	0	9	8
29	R:R:V652	R:R:Y675	37.479	6.31	Yes	Yes	2	8	8
30	R:R:V652	R:R:W649	41.4571	7.36	Yes	Yes	2	8	9
31	R:R:E653	R:R:I604	37.4679	5.47	Yes	Yes	0	9	9
32	R:R:E653	R:R:L608	55.1086	5.3	Yes	No	0	9	9
33	R:R:H640	R:R:W705	18.2032	3.17	Yes	Yes	1	9	9
34	R:R:H640	R:R:L644	23.809	9	Yes	Yes	1	9	9
35	R:R:L644	R:R:P683	36.194	3.28	Yes	Yes	0	9	8
36	R:R:P683	R:R:S645	36.0934	7.13	Yes	No	0	8	8
37	R:R:F642	R:R:Y641	10.2805	4.13	Yes	Yes	2	8	7
38	R:R:F716	R:R:W705	12.7947	5.01	No	Yes	1	9	9
39	R:R:F716	R:R:L644	12.858	6.09	No	Yes	1	9	9
40	R:R:I597	R:R:Y602	31.2065	9.67	No	Yes	0	8	8
41	R:R:I597	R:R:L591	17.2831	2.85	No	No	0	8	8
42	R:R:I597	R:R:V594	11.8374	4.61	No	Yes	0	8	8
43	R:R:E812	R:R:R601	15.972	5.82	No	Yes	3	8	8
44	R:R:E812	R:R:T596	13.901	4.23	No	No	0	8	9
45	R:R:T596	R:R:V594	11.5059	3.17	No	Yes	0	9	8
46	R:R:E653	R:R:I768	40.2466	10.93	Yes	No	0	9	8
47	R:R:L639	R:R:S622	31.4113	3	No	No	0	9	8
48	R:R:C704	R:R:S622	25.4442	3.44	Yes	No	4	9	8
49	R:R:C632	R:R:T629	15.9757	1.69	No	No	0	9	8
50	R:R:C632	R:R:C704	19.1269	7.28	No	Yes	4	9	9
51	R:R:S645	R:R:W680	33.5866	7.41	No	Yes	2	8	8
52	R:R:W649	R:R:W680	48.9738	18.74	Yes	Yes	2	9	8
53	R:R:I768	R:R:L765	33.0242	2.85	No	Yes	0	8	9
54	R:R:L657	R:R:L765	11.9306	4.15	No	Yes	7	9	9
55	R:R:L657	R:R:V661	11.4165	2.98	No	No	0	9	9
56	R:R:L765	R:R:V734	16.0949	2.98	Yes	No	7	9	9
57	R:R:I662	R:R:V661	10.2805	3.07	Yes	No	0	8	9
58	R:R:I738	R:R:V734	15.7299	3.07	Yes	No	0	9	9
59	R:R:I738	R:R:T758	12.6495	1.52	Yes	Yes	0	9	8
60	R:R:F805	R:R:H806	10.8169	2.26	No	Yes	0	8	9
61	R:R:F775	R:R:F791	11.1111	3.22	No	Yes	0	8	9
62	R:R:F817	R:R:L591	12.3813	2.44	No	No	0	7	8
63	R:R:W680	R:R:Y641	15.3984	4.82	Yes	Yes	2	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7WU2_nogp

PDB Summary
PDB	7WU2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	252
Number of Links	282
Number of Hubs	35
Number of Links mediated by Hubs	143
Number of Communities	8
Number of Nodes involved in Communities	55
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	58538
Length Of Smallest Path	3
Average Path Length	13.4229
Length of Longest Path	29
Minimum Path Strength	1.37
Average Path Strength	5.39795
Maximum Path Strength	21.45
Minimum Path Correlation	0.7
Average Path Correlation	0.923101
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	45.1158
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.7297
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cell surface receptor signaling pathway • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nuclear speck • nuclear body • nucleoplasm • organelle lumen • nuclear lumen
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q6QNK2
Sequence	>7WU2_nogp_Chain_R T N F A I L M Q V V P L E L A R G H Q V A L S S I S Y V G C S L S V L C L V A T L V T F A V L S S V S T I R N Q R Y H I H A N L S F A V L V A Q V L L L I S F R L E P G T T P C Q V M A V L L H Y F F L S A F A W M L V E G L H L Y S M V I K V F G S E D S K H R Y Y Y G M G W G F P L L I C I I S L S F A M D S Y G T S N N C W L S L A S G A I W A F V A P A L F V I V V N I G I L I A V T R V I S Q I S A D N Y K I H G D P S A F K L T A K A V A V L L P I L G T S W V F G V L A V N G C A V V F Q Y M F A T L N S L Q G L F I F L F H C L L N S E V R A A F K H K T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	10.1038/s41586-022-04619-y
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	10.1038/s41586-022-04580-w

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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You can also read or download a guide explaining the meaning of all files and numerical data.