psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q563	3.22	Yes	No	0	0	4
2	L:L:?1	R:R:L619	2.23	Yes	No	4	0	9
3	L:L:?1	R:R:W705	10.09	Yes	Yes	4	0	9
4	L:L:?1	R:R:F791	1.96	Yes	No	0	0	9
5	L:L:?1	R:R:N795	3.32	Yes	No	0	0	9
6	R:R:V553	R:R:V780	3.21	No	No	0	8	7
7	R:R:P555	R:R:V554	3.53	No	No	0	6	8
8	R:R:L708	R:R:P555	3.28	No	No	0	7	6
9	R:R:H562	R:R:L558	20.57	Yes	No	5	7	5
10	R:R:L558	R:R:Q563	9.32	No	No	0	5	4
11	R:R:L558	R:R:L566	5.54	No	No	5	5	9
12	R:R:H562	R:R:L566	16.71	Yes	No	5	7	9
13	R:R:H562	R:R:Q788	25.96	Yes	No	0	7	8
14	R:R:H562	R:R:Y789	11.98	Yes	No	0	7	9
15	R:R:F623	R:R:S567	2.64	No	No	0	6	7
16	R:R:L620	R:R:Y571	2.34	No	No	0	8	7
17	R:R:F623	R:R:Y571	12.38	No	No	6	6	7
18	R:R:R624	R:R:Y571	4.12	No	No	6	4	7
19	R:R:G573	R:R:L797	3.42	No	Yes	0	9	7
20	R:R:C574	R:R:Q616	4.58	No	No	0	8	8
21	R:R:C574	R:R:L620	4.76	No	No	0	8	8
22	R:R:Q616	R:R:S577	11.55	No	No	0	8	9
23	R:R:G799	R:R:S577	1.86	No	No	0	8	9
24	R:R:C580	R:R:F803	9.78	No	No	0	7	9
25	R:R:L581	R:R:S609	4.5	No	No	0	9	8
26	R:R:L581	R:R:V612	2.98	No	No	0	9	8
27	R:R:L581	R:R:L613	4.15	No	No	0	9	8
28	R:R:F588	R:R:T584	2.59	Yes	No	1	7	9
29	R:R:F803	R:R:T584	6.49	No	No	1	9	9
30	R:R:C807	R:R:T584	6.76	No	No	1	8	9
31	R:R:F610	R:R:L585	2.44	No	No	0	4	7
32	R:R:F588	R:R:Y602	6.19	Yes	Yes	1	7	8
33	R:R:F588	R:R:H605	2.26	Yes	Yes	1	7	9
34	R:R:C807	R:R:F588	4.19	No	Yes	1	8	7
35	R:R:K820	R:R:L591	5.64	No	No	0	8	8
36	R:R:K820	R:R:S593	4.59	No	No	0	8	8
37	R:R:A816	R:R:V594	5.09	No	No	0	8	8
38	R:R:K820	R:R:V594	3.04	No	No	0	8	8
39	R:R:I597	R:R:T596	3.04	No	No	0	8	9
40	R:R:E812	R:R:T596	2.82	Yes	No	0	8	9
41	R:R:I597	R:R:Y602	12.09	No	Yes	0	8	8
42	R:R:N599	R:R:R601	14.46	No	Yes	1	8	8
43	R:R:N599	R:R:Y602	8.14	No	Yes	1	8	8
44	R:R:H672	R:R:Q600	4.95	No	No	0	7	8
45	R:R:Q600	R:R:Y675	2.25	No	Yes	0	8	8
46	R:R:R601	R:R:Y602	5.14	Yes	Yes	1	8	8
47	R:R:H656	R:R:R601	5.64	No	Yes	0	8	8
48	R:R:E812	R:R:R601	5.82	Yes	Yes	1	8	8
49	R:R:N810	R:R:Y602	3.49	No	Yes	1	9	8
50	R:R:E812	R:R:Y602	8.98	Yes	Yes	1	8	8
51	R:R:V813	R:R:Y602	3.79	No	Yes	0	9	8
52	R:R:H603	R:R:H672	5.97	No	No	0	8	7
53	R:R:H603	R:R:Y676	3.27	No	Yes	0	8	8
54	R:R:I604	R:R:W649	5.87	No	Yes	0	9	9
55	R:R:E653	R:R:I604	2.73	Yes	No	0	9	9
56	R:R:I604	R:R:Y675	6.04	No	Yes	0	9	8
57	R:R:E653	R:R:H605	2.46	Yes	Yes	1	9	9
58	R:R:H605	R:R:I768	5.3	Yes	Yes	1	9	8
59	R:R:H605	R:R:H806	2.39	Yes	No	1	9	9
60	R:R:N607	R:R:W649	14.69	Yes	Yes	2	9	9
61	R:R:N607	R:R:Y676	4.65	Yes	Yes	2	9	8
62	R:R:N607	R:R:W680	2.26	Yes	Yes	2	9	8
63	R:R:L608	R:R:V612	2.98	No	No	0	9	8
64	R:R:L608	R:R:M650	4.24	No	No	0	9	9
65	R:R:Q616	R:R:V612	2.87	No	No	0	8	8
66	R:R:F642	R:R:V614	9.18	Yes	No	0	8	6
67	R:R:A615	R:R:F643	4.16	No	No	0	9	8
68	R:R:I621	R:R:V617	3.07	No	No	0	4	5
69	R:R:L618	R:R:M635	4.24	No	No	0	7	6
70	R:R:L618	R:R:L639	4.15	No	No	0	7	9
71	R:R:F642	R:R:L618	2.44	Yes	No	0	8	7
72	R:R:L619	R:R:W705	3.42	No	Yes	4	9	9
73	R:R:M635	R:R:S622	7.67	No	No	0	6	8
74	R:R:S622	R:R:W705	3.71	No	Yes	0	8	9
75	R:R:F623	R:R:R624	3.21	No	No	6	6	4
76	R:R:E626	R:R:L625	3.98	No	No	0	2	4
77	R:R:L625	R:R:M635	2.83	No	No	0	4	6
78	R:R:G628	R:R:P627	2.03	Yes	No	3	7	5
79	R:R:C704	R:R:P627	1.88	No	No	3	9	5
80	R:R:C632	R:R:G628	1.96	No	Yes	3	9	7
81	R:R:C704	R:R:G628	1.96	No	Yes	3	9	7
82	R:R:P631	R:R:T629	6.99	No	No	0	6	8
83	R:R:P631	R:R:T630	3.5	No	No	0	6	3
84	R:R:Q633	R:R:T630	2.83	No	No	0	5	3
85	R:R:C632	R:R:C704	7.28	No	No	3	9	9
86	R:R:H640	R:R:V637	6.92	No	No	7	9	4
87	R:R:V637	R:R:Y698	3.79	No	Yes	7	4	9
88	R:R:F642	R:R:L638	3.65	Yes	No	0	8	7
89	R:R:L639	R:R:W705	2.28	No	Yes	0	9	9
90	R:R:C687	R:R:H640	5.9	No	No	0	8	9
91	R:R:H640	R:R:Y698	14.16	No	Yes	7	9	9
92	R:R:F642	R:R:Y641	2.06	Yes	Yes	0	8	7
93	R:R:W680	R:R:Y641	2.89	Yes	Yes	0	8	7
94	R:R:P683	R:R:Y641	4.17	Yes	Yes	0	8	7
95	R:R:C687	R:R:Y641	4.03	No	Yes	0	8	7
96	R:R:F643	R:R:F716	3.22	No	No	0	8	9
97	R:R:I686	R:R:L644	2.85	No	No	0	7	9
98	R:R:L644	R:R:P719	3.28	No	No	0	9	9
99	R:R:S645	R:R:W680	7.41	No	Yes	0	8	8
100	R:R:P683	R:R:S645	3.56	Yes	No	0	8	8
101	R:R:F647	R:R:M650	4.98	Yes	No	0	9	9
102	R:R:F647	R:R:F716	3.22	Yes	No	0	9	9
103	R:R:A720	R:R:F647	2.77	No	Yes	0	9	9
104	R:R:F647	R:R:W773	14.03	Yes	Yes	0	9	9
105	R:R:W649	R:R:Y676	2.89	Yes	Yes	2	9	8
106	R:R:G679	R:R:W649	8.44	No	Yes	0	9	9
107	R:R:W649	R:R:W680	14.99	Yes	Yes	2	9	8
108	R:R:G770	R:R:M650	3.49	No	No	0	9	9
109	R:R:L651	R:R:V723	4.47	No	No	0	9	8
110	R:R:L651	R:R:V726	2.98	No	No	0	9	8
111	R:R:V652	R:R:Y675	6.31	No	Yes	0	8	8
112	R:R:M678	R:R:V652	3.04	No	No	0	7	8
113	R:R:E653	R:R:G654	3.27	Yes	No	1	9	9
114	R:R:E653	R:R:I768	10.93	Yes	Yes	1	9	8
115	R:R:E653	R:R:L769	9.28	Yes	No	1	9	9
116	R:R:G654	R:R:L769	3.42	No	No	1	9	9
117	R:R:H656	R:R:M660	3.94	No	No	0	8	8
118	R:R:H656	R:R:Y675	11.98	No	Yes	0	8	8
119	R:R:L657	R:R:V661	2.98	No	No	0	9	9
120	R:R:L657	R:R:L765	4.15	No	No	0	9	9
121	R:R:I662	R:R:Y658	9.67	No	No	0	8	8
122	R:R:K663	R:R:Y658	3.58	No	No	0	7	8
123	R:R:I730	R:R:Y658	4.84	No	No	0	8	8
124	R:R:I662	R:R:V661	3.07	No	No	0	8	9
125	R:R:D669	R:R:K671	4.15	No	No	0	6	8
126	R:R:K671	R:R:Y675	2.39	No	Yes	0	8	8
127	R:R:F682	R:R:M678	3.73	No	No	0	4	7
128	R:R:G681	R:R:P683	2.03	No	Yes	0	9	8
129	R:R:I686	R:R:I689	2.94	No	No	0	7	6
130	R:R:S690	R:R:Y698	3.82	No	Yes	0	8	9
131	R:R:D696	R:R:S697	5.89	No	No	0	3	7
132	R:R:S697	R:R:S710	6.52	No	No	0	7	4
133	R:R:A712	R:R:S697	3.42	No	No	0	7	7
134	R:R:S707	R:R:T700	3.2	No	No	0	8	4
135	R:R:N702	R:R:N703	8.17	No	No	0	3	7
136	R:R:N703	R:R:W705	20.34	No	Yes	0	7	9
137	R:R:S707	R:R:S710	6.52	No	No	0	8	4
138	R:R:I713	R:R:L708	2.85	No	No	0	8	7
139	R:R:G711	R:R:S710	3.71	No	No	0	7	4
140	R:R:I713	R:R:V717	3.07	No	No	0	8	8
141	R:R:L721	R:R:V717	2.98	No	No	0	7	8
142	R:R:A718	R:R:P719	1.87	No	No	0	7	9
143	R:R:F722	R:R:V726	2.62	No	No	0	5	8
144	R:R:I724	R:R:W773	2.35	No	Yes	0	9	9
145	R:R:I724	R:R:V774	4.61	No	No	0	9	5
146	R:R:L769	R:R:N727	12.36	No	No	0	9	9
147	R:R:G729	R:R:I728	3.53	No	No	0	5	5
148	R:R:L731	R:R:T735	2.95	No	No	0	8	9
149	R:R:L731	R:R:L765	2.77	No	No	0	8	9
150	R:R:L757	R:R:S742	3	No	No	0	8	8
151	R:R:A754	R:R:F755	2.77	No	No	0	8	6
152	R:R:K756	R:R:K760	4.31	No	No	0	6	9
153	R:R:H806	R:R:V764	4.15	No	No	0	9	8
154	R:R:L766	R:R:P767	9.85	No	Yes	0	8	9
155	R:R:L766	R:R:T771	4.42	No	No	0	8	8
156	R:R:F801	R:R:P767	7.22	No	Yes	0	8	9
157	R:R:F805	R:R:P767	2.89	No	Yes	0	8	9
158	R:R:I768	R:R:I802	2.94	Yes	No	0	8	8
159	R:R:H806	R:R:I768	13.26	No	Yes	1	9	8
160	R:R:F775	R:R:S772	2.64	No	No	0	8	9
161	R:R:F791	R:R:W773	4.01	No	Yes	0	9	9
162	R:R:N795	R:R:W773	15.82	No	Yes	0	9	9
163	R:R:F775	R:R:F787	4.29	No	No	0	8	7
164	R:R:A779	R:R:G776	1.95	No	No	0	8	9
165	R:R:F791	R:R:G776	3.01	No	No	0	9	9
166	R:R:A784	R:R:Q788	3.03	No	No	0	6	8
167	R:R:V785	R:R:V786	4.81	No	No	0	5	5
168	R:R:L794	R:R:M790	2.83	Yes	No	0	6	5
169	R:R:F801	R:R:L794	2.44	No	Yes	0	8	6
170	R:R:N795	R:R:Q798	3.96	No	No	0	9	9
171	R:R:L797	R:R:S796	6.01	Yes	No	0	7	9
172	R:R:L797	R:R:L800	4.15	Yes	No	0	7	6
173	R:R:F801	R:R:L797	2.44	No	Yes	0	8	7
174	R:R:C807	R:R:F803	4.19	No	No	1	8	9
175	R:R:N810	R:R:S811	2.98	No	No	0	9	8
176	R:R:E812	R:R:N810	2.63	Yes	No	1	8	9
177	R:R:F817	R:R:T821	7.78	No	No	0	7	8
178	R:R:H819	R:R:V823	6.92	No	No	0	8	7
179	R:R:G573	R:R:V572	1.84	No	No	0	9	5
180	R:R:G628	R:R:T629	1.82	Yes	No	0	7	8
181	R:R:G699	R:R:T700	1.82	No	No	0	8	4
182	R:R:A611	R:R:A646	1.79	No	No	0	8	7
183	R:R:A694	R:R:A712	1.79	No	No	0	6	7
184	R:R:A611	R:R:S645	1.71	No	No	0	8	8
185	R:R:G654	R:R:L657	1.71	No	No	0	9	9
186	R:R:G681	R:R:L684	1.71	No	No	0	9	5
187	R:R:A565	R:R:V564	1.7	No	No	0	6	5
188	R:R:I768	R:R:P767	1.69	Yes	Yes	0	8	9
189	R:R:A816	R:R:T596	1.68	No	No	0	8	9
190	R:R:L644	R:R:P683	1.64	No	Yes	0	9	8
191	R:R:S567	R:R:S568	1.63	No	No	0	7	5
192	R:R:S577	R:R:V578	1.62	No	No	0	9	7
193	R:R:A715	R:R:I686	1.62	No	No	0	9	7
194	R:R:A761	R:R:I738	1.62	No	No	0	9	9
195	R:R:V578	R:R:V617	1.6	No	No	0	7	5
196	R:R:V586	R:R:V590	1.6	No	No	0	6	4
197	R:R:G561	R:R:H562	1.59	No	Yes	0	2	7
198	R:R:T630	R:R:V634	1.59	No	No	0	3	4
199	R:R:A792	R:R:L566	1.58	No	No	0	8	9
200	R:R:E626	R:R:P627	1.57	No	No	0	2	5
201	R:R:A606	R:R:N607	1.56	No	Yes	0	7	9
202	R:R:I689	R:R:S692	1.55	No	No	0	6	6
203	R:R:I662	R:R:V737	1.54	No	No	0	8	8
204	R:R:I730	R:R:V726	1.54	No	No	0	8	8
205	R:R:I730	R:R:V734	1.54	No	No	0	8	9
206	R:R:M660	R:R:S667	1.53	No	No	0	8	8
207	R:R:K822	R:R:S825	1.53	No	No	0	8	8
208	R:R:I728	R:R:T771	1.52	No	No	0	5	8
209	R:R:I738	R:R:T758	1.52	No	No	0	9	8
210	R:R:G561	R:R:R560	1.5	No	No	0	2	1
211	R:R:G677	R:R:R673	1.5	No	No	0	5	3
212	R:R:L691	R:R:S690	1.5	No	No	0	4	8
213	R:R:L794	R:R:S772	1.5	Yes	No	0	6	9
214	R:R:L556	R:R:V554	1.49	No	No	0	4	8
215	R:R:L576	R:R:V572	1.49	No	No	0	5	5
216	R:R:L591	R:R:V590	1.49	No	No	0	8	4
217	R:R:L721	R:R:V777	1.49	No	No	0	7	7
218	R:R:I728	R:R:I732	1.47	No	No	0	5	4
219	R:R:L794	R:R:T793	1.47	Yes	No	0	6	5
220	R:R:L797	R:R:T793	1.47	Yes	No	0	7	5
221	R:R:N702	R:R:T700	1.46	No	No	0	3	4
222	R:R:G677	R:R:Y676	1.45	No	Yes	0	5	8
223	R:R:E668	R:R:S667	1.44	No	No	0	8	8
224	R:R:I688	R:R:L685	1.43	No	No	0	4	5
225	R:R:A559	R:R:R560	1.38	No	No	0	3	1
226	R:R:L585	R:R:L613	1.38	No	No	0	7	8
227	R:R:L804	R:R:L808	1.38	No	No	0	8	7
228	R:R:L808	R:R:L809	1.38	No	No	0	7	8
229	R:R:R814	R:R:S811	1.32	No	No	0	9	8
230	R:R:F665	R:R:V664	1.31	No	No	0	8	9
231	R:R:R736	R:R:V737	1.31	No	No	0	7	8
232	R:R:F787	R:R:V786	1.31	No	No	0	7	5
233	R:R:F817	R:R:K818	1.24	No	No	0	7	8
234	R:R:F817	R:R:L591	1.22	No	No	0	7	8
235	L:L:?1	R:R:S570	1.21	Yes	No	0	0	7
236	R:R:M695	R:R:Y698	1.2	No	Yes	0	2	9
237	R:R:Q740	R:R:R736	1.17	No	No	0	8	7
238	L:L:?1	R:R:E557	1.07	Yes	No	0	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	3.3	7	4	0
2	R:R:H562	15.362	5	5	7
3	R:R:F588	3.8075	4	1	7
4	R:R:R601	7.765	4	1	8
5	R:R:Y602	6.83143	7	1	8
6	R:R:H605	3.1025	4	1	9
7	R:R:N607	5.79	4	2	9
8	R:R:G628	1.9425	4	3	7
9	R:R:Y641	3.2875	4	0	7
10	R:R:F642	4.3325	4	0	8
11	R:R:F647	6.25	4	0	9
12	R:R:W649	9.376	5	2	9
13	R:R:E653	5.734	5	1	9
14	R:R:Y675	5.794	5	0	8
15	R:R:Y676	3.065	4	2	8
16	R:R:W680	6.8875	4	2	8
17	R:R:P683	2.85	4	0	8
18	R:R:Y698	5.7425	4	7	9
19	R:R:W705	7.968	5	4	9
20	R:R:P767	5.4125	4	0	9
21	R:R:I768	6.824	5	1	8
22	R:R:W773	9.0525	4	0	9
23	R:R:L794	2.06	4	0	6
24	R:R:L797	3.498	5	0	7
25	R:R:E812	5.0625	4	1	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q563	17.2421	3.22	Yes	No	0	0	4
2	R:R:L558	R:R:Q563	15.7399	9.32	No	No	0	5	4
3	R:R:H562	R:R:L558	11.0621	20.57	Yes	No	5	7	5
4	L:L:?1	R:R:F791	39.5704	1.96	Yes	No	0	0	9
5	R:R:F791	R:R:W773	36.8033	4.01	No	Yes	0	9	9
6	R:R:F647	R:R:W773	66.5964	14.03	Yes	Yes	0	9	9
7	R:R:F647	R:R:M650	55.2181	4.98	Yes	No	0	9	9
8	R:R:L608	R:R:M650	50.4612	4.24	No	No	0	9	9
9	R:R:L608	R:R:V612	48.063	2.98	No	No	0	9	8
10	R:R:Q616	R:R:V612	33.397	2.87	No	No	0	8	8
11	R:R:C574	R:R:Q616	18.2567	4.58	No	No	0	8	8
12	R:R:C574	R:R:L620	15.6872	4.76	No	No	0	8	8
13	R:R:L620	R:R:Y571	13.0913	2.34	No	No	0	8	7
14	L:L:?1	R:R:N795	38.648	3.32	Yes	No	0	0	9
15	R:R:N795	R:R:W773	36.6583	15.82	No	Yes	0	9	9
16	L:L:?1	R:R:W705	87.2645	10.09	Yes	Yes	4	0	9
17	R:R:L639	R:R:W705	85.9402	2.28	No	Yes	0	9	9
18	R:R:L618	R:R:L639	86.408	4.15	No	No	0	7	9
19	R:R:F642	R:R:L618	99.4005	2.44	Yes	No	0	8	7
20	R:R:F642	R:R:Y641	100	2.06	Yes	Yes	0	8	7
21	R:R:W680	R:R:Y641	98.2277	2.89	Yes	Yes	0	8	7
22	R:R:W649	R:R:W680	98.9129	14.99	Yes	Yes	2	9	8
23	R:R:I604	R:R:W649	97.3119	5.87	No	Yes	0	9	9
24	R:R:E653	R:R:I604	68.0524	2.73	Yes	No	0	9	9
25	R:R:E653	R:R:I768	32.7052	10.93	Yes	Yes	1	9	8
26	R:R:I768	R:R:P767	34.4709	1.69	Yes	Yes	0	8	9
27	R:R:F801	R:R:P767	24.7661	7.22	No	Yes	0	8	9
28	R:R:F801	R:R:L797	11.1543	2.44	No	Yes	0	8	7
29	R:R:Q616	R:R:S577	13.1045	11.55	No	No	0	8	9
30	R:R:E653	R:R:H605	21.9067	2.46	Yes	Yes	1	9	9
31	R:R:F588	R:R:H605	25.3657	2.26	Yes	Yes	1	7	9
32	R:R:L581	R:R:V612	13.1045	2.98	No	No	0	9	8
33	R:R:F588	R:R:Y602	17.7691	6.19	Yes	Yes	1	7	8
34	R:R:I604	R:R:Y675	37.9892	6.04	No	Yes	0	9	8
35	R:R:H656	R:R:Y675	29.8854	11.98	No	Yes	0	8	8
36	R:R:H656	R:R:R601	25.2075	5.64	No	Yes	0	8	8
37	R:R:E812	R:R:R601	16.2274	5.82	Yes	Yes	1	8	8
38	R:R:E812	R:R:T596	16.4976	2.82	Yes	No	0	8	9
39	R:R:A816	R:R:T596	18.9748	1.68	No	No	0	8	9
40	R:R:A816	R:R:V594	17.1235	5.09	No	No	0	8	8
41	R:R:K820	R:R:V594	15.2458	3.04	No	No	0	8	8
42	R:R:K820	R:R:L591	11.5957	5.64	No	No	0	8	8
43	R:R:L625	R:R:M635	18.7311	2.83	No	No	0	4	6
44	R:R:E626	R:R:L625	17.2421	3.98	No	No	0	2	4
45	R:R:E626	R:R:P627	15.7399	1.57	No	No	0	2	5
46	R:R:G628	R:R:P627	11.0621	2.03	Yes	No	3	7	5
47	R:R:C687	R:R:Y641	11.0225	4.03	No	Yes	0	8	7
48	R:R:P683	R:R:Y641	17.6967	4.17	Yes	Yes	0	8	7
49	R:R:L644	R:R:P683	16.2736	1.64	No	Yes	0	9	8
50	R:R:S645	R:R:W680	12.1096	7.41	No	Yes	0	8	8
51	R:R:P683	R:R:S645	10.054	3.56	Yes	No	0	8	8
52	R:R:E653	R:R:G654	27.6123	3.27	Yes	No	1	9	9
53	R:R:G654	R:R:L657	26.4066	1.71	No	No	0	9	9
54	R:R:L657	R:R:V661	20.477	2.98	No	No	0	9	9
55	R:R:I662	R:R:V661	18.9682	3.07	No	No	0	8	9
56	R:R:I662	R:R:Y658	12.9398	9.67	No	No	0	8	8
57	R:R:N703	R:R:W705	17.2421	20.34	No	Yes	0	7	9
58	R:R:N702	R:R:N703	15.7399	8.17	No	No	0	3	7
59	R:R:N702	R:R:T700	14.2245	1.46	No	No	0	3	4
60	R:R:S707	R:R:T700	11.1543	3.2	No	No	0	8	4
61	R:R:F801	R:R:L794	12.7092	2.44	No	Yes	0	8	6
62	R:R:L618	R:R:M635	13.0518	4.24	No	No	0	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Q563	3.22	4	Yes	No	0	4	0	1
L:L:?1	R:R:L619	2.23	4	Yes	No	0	9	0	1
L:L:?1	R:R:W705	10.09	4	Yes	Yes	0	9	0	1
L:L:?1	R:R:F791	1.96	4	Yes	No	0	9	0	1
L:L:?1	R:R:N795	3.32	4	Yes	No	0	9	0	1
R:R:L558	R:R:Q563	9.32	5	No	No	5	4	2	1
R:R:L619	R:R:W705	3.42	4	No	Yes	9	9	1	1
R:R:S622	R:R:W705	3.71	0	No	Yes	8	9	2	1
R:R:L639	R:R:W705	2.28	0	No	Yes	9	9	2	1
R:R:N703	R:R:W705	20.34	0	No	Yes	7	9	2	1
R:R:F791	R:R:W773	4.01	0	No	Yes	9	9	1	2
R:R:N795	R:R:W773	15.82	0	No	Yes	9	9	1	2
R:R:F791	R:R:G776	3.01	0	No	No	9	9	1	2
R:R:N795	R:R:Q798	3.96	0	No	No	9	9	1	2
L:L:?1	R:R:S570	1.21	4	Yes	No	0	7	0	1
L:L:?1	R:R:E557	1.07	4	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8X9S_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.86
Number of Linked Nodes	228
Number of Links	238
Number of Hubs	25
Number of Links mediated by Hubs	94
Number of Communities	7
Number of Nodes involved in Communities	35
Number of Links involved in Communities	44

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	28982
Length Of Smallest Path	3
Average Path Length	14.4244
Length of Longest Path	33
Minimum Path Strength	1.14
Average Path Strength	5.22159
Maximum Path Strength	23.265
Minimum Path Correlation	0.7
Average Path Correlation	0.929927
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	48.1729
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.8808
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cell surface receptor signaling pathway • multicellular organismal process • system process • nervous system process • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • intracellular organelle lumen • nuclear speck • ribonucleoprotein granule • intracellular organelle • nuclear body • nucleoplasm • organelle lumen • membraneless organelle • supramolecular complex • nuclear ribonucleoprotein granule • nuclear lumen • cytosol • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • molecular function regulator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • insulin-like growth factor receptor binding • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • sensory perception of chemical stimulus • sensory perception
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DHT
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	DHT
Name	Stanolone
Synonyms	17beta-Hydroxy-5alpha-androstan-3-one
Identifier
Formula	C19 H30 O2
Molecular Weight	290.44
SMILES
PubChem	10635
Formal Charge	0
Total Atoms	51
Total Chiral Atoms	7
Total Bonds	54
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q6QNK2
Sequence	>8X9S_nogp_Chain_R V V P L E L A R G H Q V A L S S I S Y V G C S L S V L C L V A T L V T F A V L S S V S T I R N Q R Y H I H A N L S F A V L V A Q V L L L I S F R L E P G T T P C Q V M A V L L H Y F F L S A F A W M L V E G L H L Y S M V I K V F G S E D S K H R Y Y Y G M G W G F P L L I C I I S L S F A M D S Y G T S N N C W L S L A S G A I W A F V A P A L F V I V V N I G I L I A V T R V I S Q I S A D N S A F K L T A K A V A V L L P I L G T S W V F G V L A V N G C A V V F Q Y M F A T L N S L Q G L F I F L F H C L L N S E V R A A F K H K T K V W S L T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9V0U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9V0U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165

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