psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:E557	4.27	Yes	No	0	0	4
2	L:L:?1	R:R:H640	6.21	Yes	No	0	0	9
3	L:L:?1	R:R:F643	7.85	Yes	No	5	0	8
4	L:L:?1	R:R:W705	15.59	Yes	No	0	0	9
5	L:L:?1	R:R:F716	4.9	Yes	No	5	0	9
6	R:R:P555	R:R:V554	3.53	No	No	0	6	8
7	R:R:L708	R:R:P555	6.57	No	No	0	7	6
8	R:R:H562	R:R:L558	7.71	Yes	No	4	7	5
9	R:R:L558	R:R:Q563	11.98	No	No	0	5	4
10	R:R:L558	R:R:L566	5.54	No	No	4	5	9
11	R:R:G561	R:R:R560	3	No	No	0	2	1
12	R:R:H562	R:R:L566	16.71	Yes	No	4	7	9
13	R:R:H562	R:R:Q788	24.73	Yes	No	4	7	8
14	R:R:H562	R:R:Y789	13.07	Yes	No	4	7	9
15	R:R:A565	R:R:V564	1.7	No	No	0	6	5
16	R:R:A565	R:R:I569	1.62	No	No	0	6	9
17	R:R:F623	R:R:S567	2.64	No	No	0	6	7
18	R:R:L620	R:R:Y571	2.34	No	No	0	8	7
19	R:R:F623	R:R:Y571	13.41	No	No	0	6	7
20	R:R:G573	R:R:V572	1.84	No	No	0	9	5
21	R:R:L576	R:R:V572	2.98	No	No	0	5	5
22	R:R:G573	R:R:L797	3.42	No	No	0	9	7
23	R:R:C574	R:R:Q616	7.63	No	No	0	8	8
24	R:R:C574	R:R:L620	7.94	No	No	0	8	8
25	R:R:S577	R:R:V578	1.62	No	No	0	9	7
26	R:R:Q616	R:R:S577	10.11	No	No	0	8	9
27	R:R:G799	R:R:S577	1.86	No	No	0	8	9
28	R:R:C580	R:R:F803	11.17	No	Yes	0	7	9
29	R:R:L581	R:R:S609	4.5	No	No	0	9	8
30	R:R:L581	R:R:V612	2.98	No	No	0	9	8
31	R:R:L581	R:R:L613	4.15	No	No	0	9	8
32	R:R:F803	R:R:T584	6.49	Yes	No	6	9	9
33	R:R:C807	R:R:T584	6.76	No	No	6	8	9
34	R:R:F610	R:R:L585	3.65	No	No	0	4	7
35	R:R:F588	R:R:I597	2.51	No	Yes	0	7	8
36	R:R:A606	R:R:F588	8.32	No	No	0	7	7
37	R:R:I597	R:R:L591	4.28	Yes	Yes	0	8	8
38	R:R:F817	R:R:L591	2.44	No	Yes	0	7	8
39	R:R:K820	R:R:L591	5.64	No	Yes	0	8	8
40	R:R:S593	R:R:V594	1.62	No	Yes	1	8	8
41	R:R:K820	R:R:S593	4.59	No	No	1	8	8
42	R:R:T596	R:R:V594	4.76	No	Yes	1	9	8
43	R:R:A816	R:R:V594	1.7	No	Yes	1	8	8
44	R:R:H819	R:R:V594	2.77	No	Yes	0	8	8
45	R:R:K820	R:R:V594	3.04	No	Yes	1	8	8
46	R:R:I597	R:R:T596	4.56	Yes	No	1	8	9
47	R:R:A816	R:R:T596	3.36	No	No	1	8	9
48	R:R:I597	R:R:Y602	10.88	Yes	Yes	1	8	8
49	R:R:A816	R:R:I597	1.62	No	Yes	1	8	8
50	R:R:N599	R:R:R601	16.87	No	Yes	1	8	8
51	R:R:N599	R:R:Y602	9.3	No	Yes	1	8	8
52	R:R:H672	R:R:Q600	3.71	No	No	0	7	8
53	R:R:R601	R:R:Y602	5.14	Yes	Yes	1	8	8
54	R:R:H656	R:R:R601	5.64	No	Yes	0	8	8
55	R:R:E812	R:R:R601	4.65	No	Yes	1	8	8
56	R:R:N810	R:R:Y602	5.81	Yes	Yes	1	9	8
57	R:R:E812	R:R:Y602	14.59	No	Yes	1	8	8
58	R:R:V813	R:R:Y602	3.79	No	Yes	1	9	8
59	R:R:H603	R:R:H672	9.55	No	No	0	8	7
60	R:R:H603	R:R:Y676	2.18	No	Yes	0	8	8
61	R:R:I604	R:R:N607	4.25	No	No	2	9	9
62	R:R:I604	R:R:W649	5.87	No	Yes	2	9	9
63	R:R:I604	R:R:Y675	6.04	No	No	0	9	8
64	R:R:E653	R:R:H605	6.15	No	No	0	9	9
65	R:R:H605	R:R:H806	2.39	No	Yes	0	9	9
66	R:R:N607	R:R:W649	27.12	No	Yes	2	9	9
67	R:R:N607	R:R:Y676	3.49	No	Yes	2	9	8
68	R:R:L608	R:R:W649	3.42	No	Yes	0	9	9
69	R:R:L608	R:R:M650	5.65	No	Yes	0	9	9
70	R:R:A611	R:R:S645	1.71	No	Yes	0	8	8
71	R:R:A646	R:R:V612	1.7	No	No	0	7	8
72	R:R:F642	R:R:V614	13.11	No	No	0	8	6
73	R:R:A615	R:R:F643	2.77	No	No	0	9	8
74	R:R:I621	R:R:V617	3.07	No	No	0	4	5
75	R:R:L618	R:R:L639	2.77	No	No	0	7	9
76	R:R:F642	R:R:L618	2.44	No	No	0	8	7
77	R:R:L619	R:R:L639	2.77	No	No	0	9	9
78	R:R:M635	R:R:S622	6.13	Yes	No	7	6	8
79	R:R:L639	R:R:S622	6.01	No	No	0	9	8
80	R:R:C704	R:R:S622	1.72	No	No	7	9	8
81	R:R:F623	R:R:R624	2.14	No	No	0	6	4
82	R:R:G628	R:R:P627	2.03	No	No	0	7	5
83	R:R:P631	R:R:T629	5.25	No	No	0	6	8
84	R:R:P631	R:R:T630	5.25	No	No	0	6	3
85	R:R:Q633	R:R:T630	4.25	No	No	0	5	3
86	R:R:C632	R:R:C704	7.28	No	No	0	9	9
87	R:R:C704	R:R:M635	3.24	No	Yes	7	9	6
88	R:R:L638	R:R:V637	2.98	No	No	0	7	4
89	R:R:V637	R:R:Y698	6.31	No	Yes	0	4	9
90	R:R:H640	R:R:L706	11.57	No	No	0	9	9
91	R:R:F642	R:R:Y641	5.16	No	Yes	0	8	7
92	R:R:W680	R:R:Y641	5.79	No	Yes	0	8	7
93	R:R:P683	R:R:Y641	2.78	Yes	Yes	0	8	7
94	R:R:C687	R:R:Y641	4.03	No	Yes	0	8	7
95	R:R:F643	R:R:F716	4.29	No	No	5	8	9
96	R:R:L644	R:R:P683	1.64	No	Yes	0	9	8
97	R:R:I686	R:R:L644	5.71	No	No	8	7	9
98	R:R:L644	R:R:P719	3.28	No	No	8	9	9
99	R:R:S645	R:R:W649	2.47	Yes	Yes	2	8	9
100	R:R:S645	R:R:W680	6.18	Yes	No	2	8	8
101	R:R:P683	R:R:S645	3.56	Yes	Yes	0	8	8
102	R:R:F647	R:R:M650	4.98	No	Yes	0	9	9
103	R:R:A720	R:R:F647	4.16	No	No	0	9	9
104	R:R:F647	R:R:W773	14.03	No	Yes	0	9	9
105	R:R:A648	R:R:P683	1.87	No	Yes	0	7	8
106	R:R:V652	R:R:W649	2.45	No	Yes	0	8	9
107	R:R:W649	R:R:Y676	3.86	Yes	Yes	2	9	8
108	R:R:G679	R:R:W649	2.81	No	Yes	0	9	9
109	R:R:W649	R:R:W680	16.87	Yes	No	2	9	8
110	R:R:G770	R:R:M650	1.75	No	Yes	0	9	9
111	R:R:L651	R:R:V723	5.96	No	No	0	9	8
112	R:R:V652	R:R:Y675	3.79	No	No	0	8	8
113	R:R:E653	R:R:G654	1.64	No	No	0	9	9
114	R:R:E653	R:R:I768	6.83	No	Yes	0	9	8
115	R:R:G654	R:R:L657	1.71	No	No	0	9	9
116	R:R:G654	R:R:L769	1.71	No	No	0	9	9
117	R:R:H656	R:R:M660	2.63	No	No	0	8	8
118	R:R:H656	R:R:Y675	11.98	No	No	0	8	8
119	R:R:L657	R:R:V661	2.98	No	No	0	9	9
120	R:R:L657	R:R:L765	4.15	No	No	0	9	9
121	R:R:I662	R:R:Y658	8.46	No	No	10	8	8
122	R:R:K663	R:R:Y658	3.58	No	No	10	7	8
123	R:R:I730	R:R:Y658	4.84	No	No	0	8	8
124	R:R:I662	R:R:K663	2.91	No	No	10	8	7
125	R:R:E668	R:R:S667	5.75	No	No	0	8	8
126	R:R:D669	R:R:K671	6.91	No	No	0	6	8
127	R:R:R673	R:R:Y674	2.06	No	No	0	3	5
128	R:R:F682	R:R:M678	9.95	No	No	0	4	7
129	R:R:G681	R:R:P683	2.03	No	Yes	0	9	8
130	R:R:G681	R:R:L684	1.71	No	No	0	9	5
131	R:R:A715	R:R:I686	1.62	No	No	0	9	7
132	R:R:I686	R:R:P719	1.69	No	No	8	7	9
133	R:R:I689	R:R:S692	4.64	No	No	0	6	6
134	R:R:A694	R:R:S690	1.71	No	No	3	6	8
135	R:R:S690	R:R:Y698	6.36	No	Yes	3	8	9
136	R:R:A694	R:R:Y698	2.67	No	Yes	3	6	9
137	R:R:A694	R:R:A712	1.79	No	Yes	3	6	7
138	R:R:D696	R:R:S697	5.89	No	No	0	3	7
139	R:R:S697	R:R:S710	6.52	No	Yes	3	7	4
140	R:R:A712	R:R:S697	3.42	Yes	No	3	7	7
141	R:R:N702	R:R:N703	9.54	No	No	0	3	7
142	R:R:N703	R:R:W705	19.21	No	No	0	7	9
143	R:R:A709	R:R:S707	1.71	No	No	0	2	8
144	R:R:S707	R:R:S710	3.26	No	Yes	0	8	4
145	R:R:G711	R:R:S710	1.86	No	Yes	0	7	4
146	R:R:A712	R:R:S710	1.71	Yes	Yes	3	7	4
147	R:R:I713	R:R:V717	3.07	No	No	0	8	8
148	R:R:A718	R:R:P719	1.87	No	No	0	7	9
149	R:R:F722	R:R:V726	2.62	No	No	0	5	8
150	R:R:I724	R:R:W773	2.35	No	Yes	0	9	9
151	R:R:L769	R:R:N727	15.1	No	No	0	9	9
152	R:R:G770	R:R:N727	1.7	No	No	0	9	9
153	R:R:G729	R:R:I728	1.76	No	No	0	5	5
154	R:R:L731	R:R:T735	2.95	No	No	0	8	9
155	R:R:L731	R:R:L765	2.77	No	No	0	8	9
156	R:R:I738	R:R:V734	3.07	No	No	0	9	9
157	R:R:Q740	R:R:R736	3.5	No	No	0	8	7
158	R:R:I738	R:R:L757	2.85	No	Yes	0	9	8
159	R:R:A761	R:R:I738	1.62	No	No	0	9	9
160	R:R:L757	R:R:S742	7.51	Yes	No	0	8	8
161	R:R:K756	R:R:K760	4.31	No	No	0	6	9
162	R:R:L757	R:R:T758	2.95	Yes	No	0	8	8
163	R:R:H806	R:R:V764	4.15	Yes	No	0	9	8
164	R:R:L765	R:R:L769	5.54	No	No	0	9	9
165	R:R:L766	R:R:P767	8.21	No	Yes	0	8	9
166	R:R:L766	R:R:T771	2.95	No	No	0	8	8
167	R:R:I768	R:R:P767	3.39	Yes	Yes	0	8	9
168	R:R:F801	R:R:P767	5.78	No	Yes	0	8	9
169	R:R:F805	R:R:P767	2.89	No	Yes	0	8	9
170	R:R:I768	R:R:I802	5.89	Yes	No	0	8	8
171	R:R:H806	R:R:I768	17.23	Yes	Yes	0	9	8
172	R:R:F791	R:R:W773	4.01	Yes	Yes	9	9	9
173	R:R:N795	R:R:W773	23.73	No	Yes	9	9	9
174	R:R:F775	R:R:F787	3.22	No	No	0	8	7
175	R:R:A779	R:R:G776	1.95	No	No	0	8	9
176	R:R:F791	R:R:G776	4.52	Yes	No	0	9	9
177	R:R:C783	R:R:G782	1.96	No	No	0	4	3
178	R:R:V785	R:R:V786	3.21	No	No	0	5	5
179	R:R:Q788	R:R:Y789	2.25	No	No	4	8	9
180	R:R:F791	R:R:N795	7.25	Yes	No	9	9	9
181	R:R:L797	R:R:S796	3	No	No	0	7	9
182	R:R:G799	R:R:I802	1.76	No	No	0	8	8
183	R:R:F801	R:R:L800	2.44	No	No	0	8	6
184	R:R:C807	R:R:F803	4.19	No	Yes	6	8	9
185	R:R:F805	R:R:H806	2.26	No	Yes	0	8	9
186	R:R:E812	R:R:N810	11.83	No	Yes	1	8	9
187	R:R:N810	R:R:V813	5.91	Yes	No	1	9	9
188	R:R:F817	R:R:T821	7.78	No	No	0	7	8
189	R:R:H819	R:R:V823	5.54	No	No	0	8	7
190	R:R:K822	R:R:S825	4.59	No	No	0	8	8
191	R:R:V553	R:R:V780	1.6	No	No	0	8	7
192	R:R:V578	R:R:V617	1.6	No	No	0	7	5
193	R:R:S609	R:R:T584	1.6	No	No	0	8	9
194	R:R:S701	R:R:T700	1.6	No	No	0	3	4
195	R:R:S707	R:R:T700	1.6	No	No	0	8	4
196	R:R:C580	R:R:L800	1.59	No	No	0	7	6
197	R:R:T587	R:R:V586	1.59	No	No	0	8	6
198	R:R:T630	R:R:V634	1.59	No	No	0	3	4
199	R:R:A792	R:R:L566	1.58	No	No	0	8	9
200	R:R:A712	R:R:L706	1.58	Yes	No	0	7	9
201	R:R:E557	R:R:P555	1.57	No	No	0	4	6
202	R:R:E626	R:R:P627	1.57	No	No	0	2	5
203	R:R:T735	R:R:T758	1.57	No	No	0	9	8
204	R:R:I730	R:R:V726	1.54	No	No	0	8	8
205	R:R:I730	R:R:V734	1.54	No	No	0	8	9
206	R:R:I741	R:R:V737	1.54	No	No	0	8	8
207	R:R:K663	R:R:S659	1.53	No	No	0	7	8
208	R:R:A784	R:R:Q788	1.52	No	No	0	6	8
209	R:R:M790	R:R:V786	1.52	No	No	0	5	5
210	R:R:L757	R:R:S753	1.5	Yes	No	0	8	6
211	R:R:L794	R:R:S772	1.5	No	No	0	6	9
212	R:R:L591	R:R:V590	1.49	Yes	No	0	8	4
213	R:R:L691	R:R:V637	1.49	No	No	0	4	4
214	R:R:L651	R:R:V726	1.49	No	No	0	9	8
215	R:R:L721	R:R:V777	1.49	No	No	0	7	7
216	R:R:N745	R:R:S742	1.49	No	No	0	6	8
217	R:R:N810	R:R:S811	1.49	Yes	No	0	9	8
218	R:R:I724	R:R:I728	1.47	No	No	0	9	5
219	R:R:L797	R:R:T793	1.47	No	No	0	7	5
220	R:R:L826	R:R:T827	1.47	No	No	0	8	8
221	R:R:G677	R:R:Y676	1.45	No	Yes	0	5	8
222	R:R:Q563	R:R:S567	1.44	No	No	0	4	7
223	R:R:F682	R:R:P683	1.44	No	Yes	0	4	8
224	R:R:I688	R:R:L685	1.43	No	No	0	4	5
225	R:R:I713	R:R:L706	1.43	No	No	0	8	9
226	R:R:I713	R:R:L708	1.43	No	No	0	8	7
227	R:R:L625	R:R:M635	1.41	No	Yes	0	4	6
228	R:R:L638	R:R:M635	1.41	No	Yes	0	7	6
229	R:R:L691	R:R:M695	1.41	No	No	0	4	2
230	R:R:A583	R:R:F803	1.39	No	Yes	0	6	9
231	R:R:A754	R:R:F755	1.39	No	No	0	8	6
232	R:R:L585	R:R:L613	1.38	No	No	0	7	8
233	R:R:L804	R:R:L808	1.38	No	No	0	8	7
234	R:R:L808	R:R:L809	1.38	No	No	0	7	8
235	R:R:M650	R:R:Q798	1.36	Yes	No	0	9	9
236	R:R:E626	R:R:L625	1.33	No	No	0	2	4
237	R:R:A636	R:R:Y698	1.33	No	Yes	0	9	9
238	R:R:F693	R:R:S692	1.32	No	No	0	5	6
239	R:R:R814	R:R:S811	1.32	No	No	0	9	8
240	R:R:R560	R:R:V564	1.31	No	No	0	1	5
241	R:R:D744	R:R:Q740	1.31	No	No	0	6	8
242	R:R:F775	R:R:V774	1.31	No	No	0	8	5
243	R:R:S825	R:R:W824	1.24	No	No	0	8	7
244	R:R:F801	R:R:L794	1.22	No	No	0	8	6
245	R:R:Q563	R:R:R560	1.17	No	No	0	4	1
246	R:R:F775	R:R:F791	1.07	No	Yes	0	8	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.764	5	5	0
2	R:R:H562	15.555	4	4	7
3	R:R:L591	3.4625	4	0	8
4	R:R:V594	2.778	5	1	8
5	R:R:I597	4.77	5	1	8
6	R:R:R601	8.075	4	1	8
7	R:R:Y602	8.25167	6	1	8
8	R:R:M635	3.0475	4	7	6
9	R:R:Y641	4.44	4	0	7
10	R:R:S645	3.48	4	2	8
11	R:R:W649	8.10875	8	2	9
12	R:R:M650	3.435	4	0	9
13	R:R:Y676	2.745	4	2	8
14	R:R:P683	2.22	6	0	8
15	R:R:Y698	4.1675	4	3	9
16	R:R:S710	3.3375	4	3	4
17	R:R:A712	2.125	4	3	7
18	R:R:L757	3.7025	4	0	8
19	R:R:P767	5.0675	4	0	9
20	R:R:I768	8.335	4	0	8
21	R:R:W773	11.03	4	9	9
22	R:R:F791	4.2125	4	9	9
23	R:R:F803	5.81	4	6	9
24	R:R:H806	6.5075	4	0	9
25	R:R:N810	6.26	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H640	12.8991	6.21	Yes	No	0	0	9
2	R:R:H640	R:R:L706	14.5367	11.57	No	No	0	9	9
3	R:R:A712	R:R:L706	24.1757	1.58	Yes	No	0	7	9
4	R:R:A694	R:R:A712	37.5065	1.79	No	Yes	3	6	7
5	R:R:A694	R:R:Y698	38.7272	2.67	No	Yes	3	6	9
6	R:R:V637	R:R:Y698	42.8657	6.31	No	Yes	0	4	9
7	R:R:L638	R:R:V637	46.8627	2.98	No	No	0	7	4
8	R:R:L638	R:R:M635	48.1652	1.41	No	Yes	0	7	6
9	R:R:M635	R:R:S622	53.904	6.13	Yes	No	7	6	8
10	R:R:L639	R:R:S622	58.0499	6.01	No	No	0	9	8
11	R:R:L618	R:R:L639	60.3722	2.77	No	No	0	7	9
12	R:R:F642	R:R:L618	61.3323	2.44	No	No	0	8	7
13	R:R:F642	R:R:Y641	63.5653	5.16	No	Yes	0	8	7
14	R:R:W680	R:R:Y641	61.2728	5.79	No	Yes	0	8	7
15	R:R:W649	R:R:W680	61.444	16.87	Yes	No	2	9	8
16	R:R:L608	R:R:W649	100	3.42	No	Yes	0	9	9
17	R:R:L608	R:R:M650	99.7097	5.65	No	Yes	0	9	9
18	R:R:G770	R:R:M650	93.6584	1.75	No	Yes	0	9	9
19	R:R:G770	R:R:N727	93.1299	1.7	No	No	0	9	9
20	R:R:L769	R:R:N727	92.5865	15.1	No	No	0	9	9
21	R:R:G654	R:R:L769	75.2066	1.71	No	No	0	9	9
22	R:R:E653	R:R:G654	80.9602	1.64	No	No	0	9	9
23	R:R:E653	R:R:I768	74.3655	6.83	No	Yes	0	9	8
24	R:R:I768	R:R:I802	43.7291	5.89	Yes	No	0	8	8
25	R:R:G799	R:R:I802	42.233	1.76	No	No	0	8	8
26	R:R:G799	R:R:S577	40.722	1.86	No	No	0	8	9
27	R:R:Q616	R:R:S577	34.5292	10.11	No	No	0	8	9
28	R:R:C574	R:R:Q616	32.9438	7.63	No	No	0	8	8
29	R:R:C574	R:R:L620	31.3361	7.94	No	No	0	8	8
30	R:R:L620	R:R:Y571	29.7134	2.34	No	No	0	8	7
31	R:R:F623	R:R:Y571	28.0834	13.41	No	No	0	6	7
32	R:R:F623	R:R:S567	24.786	2.64	No	No	0	6	7
33	R:R:Q563	R:R:S567	23.1187	1.44	No	No	0	4	7
34	R:R:L558	R:R:Q563	12.7577	11.98	No	No	0	5	4
35	R:R:I768	R:R:P767	34.1645	3.39	Yes	Yes	0	8	9
36	R:R:F801	R:R:P767	28.3364	5.78	No	Yes	0	8	9
37	R:R:F801	R:R:L800	23.3122	2.44	No	No	0	8	6
38	R:R:C580	R:R:L800	21.6077	1.59	No	No	0	7	6
39	R:R:C580	R:R:F803	19.8884	11.17	No	Yes	0	7	9
40	R:R:F803	R:R:T584	14.5813	6.49	Yes	No	6	9	9
41	R:R:S609	R:R:T584	12.8619	1.6	No	No	0	8	9
42	R:R:L581	R:R:S609	11.0681	4.5	No	No	0	9	8
43	R:R:I604	R:R:W649	41.6822	5.87	No	Yes	2	9	9
44	R:R:I604	R:R:Y675	42.1362	6.04	No	No	0	9	8
45	R:R:H656	R:R:Y675	80.4466	11.98	No	No	0	8	8
46	R:R:H656	R:R:R601	75.8318	5.64	No	Yes	0	8	8
47	R:R:R601	R:R:Y602	60.8932	5.14	Yes	Yes	1	8	8
48	R:R:I597	R:R:Y602	49.3189	10.88	Yes	Yes	1	8	8
49	R:R:V652	R:R:W649	41.6747	2.45	No	Yes	0	8	9
50	R:R:V652	R:R:Y675	40.6699	3.79	No	No	0	8	8
51	R:R:I597	R:R:L591	15.5341	4.28	Yes	Yes	0	8	8
52	R:R:I597	R:R:T596	13.0703	4.56	Yes	No	1	8	9
53	R:R:T596	R:R:V594	10.428	4.76	No	Yes	1	9	8
54	R:R:A816	R:R:I597	13.2713	1.62	No	Yes	1	8	8
55	R:R:A816	R:R:V594	10.629	1.7	No	Yes	1	8	8
56	R:R:H819	R:R:V594	10.5173	2.77	No	Yes	0	8	8
57	R:R:E812	R:R:R601	10.1228	4.65	No	Yes	1	8	8
58	R:R:P683	R:R:S645	15.2661	3.56	Yes	Yes	0	8	8
59	R:R:F647	R:R:M650	21.3621	4.98	No	Yes	0	9	9
60	R:R:F647	R:R:W773	18.2062	14.03	No	Yes	0	9	9
61	R:R:L765	R:R:L769	33.3978	5.54	No	No	0	9	9
62	R:R:L731	R:R:L765	37.8191	2.77	No	No	0	8	9
63	R:R:L731	R:R:T735	35.9434	2.95	No	No	0	8	9
64	R:R:T735	R:R:T758	34.0305	1.57	No	No	0	9	8
65	R:R:L757	R:R:T758	32.3186	2.95	Yes	No	0	8	8
66	R:R:I738	R:R:L757	24.7041	2.85	No	Yes	0	9	8
67	R:R:I738	R:R:V734	20.7294	3.07	No	No	0	9	9
68	R:R:I730	R:R:V734	18.7123	1.54	No	No	0	8	9
69	R:R:G654	R:R:L657	11.4552	1.71	No	No	0	9	9
70	R:R:L657	R:R:L765	10.8299	4.15	No	No	0	9	9
71	R:R:A712	R:R:S710	10.2642	1.71	Yes	Yes	3	7	4
72	R:R:F791	R:R:W773	10.0037	4.01	Yes	Yes	9	9	9
73	R:R:N810	R:R:S811	10.6513	1.49	Yes	No	0	9	8
74	R:R:S645	R:R:W649	16.9259	2.47	Yes	Yes	2	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:E557	4.27	5	Yes	No	0	4	0	1
L:L:?1	R:R:H640	6.21	5	Yes	No	0	9	0	1
L:L:?1	R:R:F643	7.85	5	Yes	No	0	8	0	1
L:L:?1	R:R:W705	15.59	5	Yes	No	0	9	0	1
L:L:?1	R:R:F716	4.9	5	Yes	No	0	9	0	1
R:R:A615	R:R:F643	2.77	0	No	No	9	8	2	1
R:R:H640	R:R:L706	11.57	0	No	No	9	9	1	2
R:R:F643	R:R:F716	4.29	5	No	No	8	9	1	1
R:R:N703	R:R:W705	19.21	0	No	No	7	9	2	1
R:R:E557	R:R:P555	1.57	0	No	No	4	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IV2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.62
Number of Linked Nodes	239
Number of Links	246
Number of Hubs	25
Number of Links mediated by Hubs	99
Number of Communities	10
Number of Nodes involved in Communities	47
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	26535
Length Of Smallest Path	3
Average Path Length	17.2231
Length of Longest Path	41
Minimum Path Strength	1.19
Average Path Strength	5.03167
Maximum Path Strength	21.995
Minimum Path Correlation	0.7
Average Path Correlation	0.924247
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.77778
Average % Of Corr. Nodes	43.0684
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	29.9157
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cell surface receptor signaling pathway • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular organelle lumen • nuclear speck • ribonucleoprotein granule • nuclear body • nucleoplasm • organelle lumen • membraneless organelle • supramolecular complex • nuclear ribonucleoprotein granule • nuclear lumen
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DHT
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	DHT
Name	Stanolone
Synonyms	17beta-Hydroxy-5alpha-androstan-3-one
Identifier
Formula	C19 H30 O2
Molecular Weight	290.44
SMILES
PubChem	10635
Formal Charge	0
Total Atoms	51
Total Chiral Atoms	7
Total Bonds	54
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q6QNK2
Sequence	>9IV2_nogp_Chain_R V V P L E L A R G H Q V A L S S I S Y V G C S L S V L C L V A T L V T F A V L S S V S T I R N Q R Y H I H A N L S F A V L V A Q V L L L I S F R L E P G T T P C Q V M A V L L H Y F F L S A F A W M L V E G L H L Y S M V I K V F G S E D S K H R Y Y Y G M G W G F P L L I C I I S L S F A M D S Y G T S N N C W L S L A S G A I W A F V A P A L F V I V V N I G I L I A V T R V I S Q I S A D N S A F K L T A K A V A V L L P I L G T S W V F G V L A V N G C A V V F Q Y M F A T L N S L Q G L F I F L F H C L L N S E V R A A F K H K T K V W S L T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9V0U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9V0U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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