CodeDHT
NameStanolone
Synonyms17beta-Hydroxy-5alpha-androstan-3-one
Identifier
FormulaC19 H30 O2
Molecular Weight290.44
SMILES
PubChem10635
Formal Charge0
Total Atoms51
Total Chiral Atoms7
Total Bonds54
Total Aromatic Bonds0
Networks6
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This ligand is also present in the following 6 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8X9S B2 Adhesion Adhesion ADGRD1 Homo Sapiens 5alpha-DHT - chim(NtGi1-Gs)/Beta1/Gamma2 3.49 2025-02-12 doi.org/10.1016/j.cell.2025.01.006

A 2D representation of the interactions of DHT in 8X9S
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Q563 3.22 0 Yes No 0 4 0 1
L:L:?1 R:R:W705 10.09 0 Yes Yes 0 9 0 1
L:L:?1 R:R:N795 3.32 0 Yes No 0 9 0 1
R:R:L558 R:R:Q563 9.32 28 No No 5 4 2 1
R:R:L619 R:R:W705 3.42 0 No Yes 9 9 2 1
R:R:S622 R:R:W705 3.71 0 No Yes 8 9 2 1
R:R:N703 R:R:W705 20.34 0 No Yes 7 9 2 1
R:R:N795 R:R:W773 15.82 0 No Yes 9 9 1 2
R:R:N795 R:R:Q798 3.96 0 No No 9 9 1 2
L:L:?1 R:R:S570 1.21 0 Yes No 0 7 0 1
L:L:?1 R:R:E557 1.07 0 Yes No 0 4 0 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub1.00
Average Interaction Strength3.78
Average Nodes In Shell12.00
Average Hubs In Shell3.00
Average Links In Shell11.00
Average Links Mediated by Hubs In Shell9.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IV1 B2 Adhesion Adhesion ADGRD1 Homo Sapiens 5alpha-DHT - chim(NtGi1-Gs)/Beta1/Gamma2 2.98 2025-02-12 doi.org/10.1016/j.cell.2025.01.006

A 2D representation of the interactions of DHT in 9IV1
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:L619 5.57 8 Yes No 0 9 0 1
L:L:?1 R:R:H640 5.18 8 Yes Yes 0 9 0 1
L:L:?1 R:R:F643 10.79 8 Yes Yes 0 8 0 1
L:L:?1 R:R:W705 32.1 8 Yes No 0 9 0 1
L:L:?1 R:R:L706 5.57 8 Yes No 0 9 0 1
L:L:?1 R:R:L708 10.03 8 Yes No 0 7 0 1
L:L:?1 R:R:F716 22.56 8 Yes Yes 0 9 0 1
R:R:A615 R:R:F643 6.93 0 No Yes 9 8 2 1
R:R:H640 R:R:L644 3.86 0 Yes No 9 9 1 2
R:R:C687 R:R:H640 4.42 0 No Yes 8 9 2 1
R:R:H640 R:R:Y698 10.89 0 Yes Yes 9 9 1 2
R:R:A715 R:R:H640 5.85 0 No Yes 9 9 2 1
R:R:F643 R:R:F716 8.57 8 Yes Yes 8 9 1 1
R:R:F647 R:R:F716 10.72 8 Yes Yes 9 9 2 1
R:R:F647 R:R:W773 18.04 8 Yes Yes 9 9 2 2
R:R:L706 R:R:Y698 19.93 0 No Yes 9 9 1 2
R:R:N703 R:R:W705 25.99 0 No No 7 9 2 1
R:R:I713 R:R:L708 7.14 0 No No 8 7 2 1
R:R:F716 R:R:W773 6.01 8 Yes Yes 9 9 1 2
R:R:F643 R:R:L639 3.65 8 Yes No 8 9 1 2
R:R:A712 R:R:L706 3.15 0 No No 7 9 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength13.11
Average Nodes In Shell19.00
Average Hubs In Shell7.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IV2 B2 Adhesion Adhesion ADGRD1 Homo Sapiens 5alpha-DHT - chim(NtGi1-Gs)/Beta1/Gamma2 3.53 2025-02-12 doi.org/10.1016/j.cell.2025.01.006

A 2D representation of the interactions of DHT in 9IV2
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:E557 4.27 22 Yes No 0 4 0 1
L:L:?1 R:R:H640 6.21 22 Yes No 0 9 0 1
L:L:?1 R:R:F643 7.85 22 Yes No 0 8 0 1
L:L:?1 R:R:W705 15.59 22 Yes No 0 9 0 1
L:L:?1 R:R:F716 4.9 22 Yes No 0 9 0 1
R:R:A615 R:R:F643 2.77 0 No No 9 8 2 1
R:R:H640 R:R:L706 11.57 0 No No 9 9 1 2
R:R:F643 R:R:F716 4.29 22 No No 8 9 1 1
R:R:N703 R:R:W705 19.21 0 No No 7 9 2 1
R:R:E557 R:R:P555 1.57 0 No No 4 6 1 2
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub0.00
Average Interaction Strength7.76
Average Nodes In Shell10.00
Average Hubs In Shell1.00
Average Links In Shell10.00
Average Links Mediated by Hubs In Shell5.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub1.33
Average Interaction Strength8.14
Average Nodes In Shell14.17
Average Hubs In Shell3.67
Average Links In Shell14.83
Average Links Mediated by Hubs In Shell11.33

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)