psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	12.18	Yes	Yes	1	0	7
2	L:L:?1	R:R:I104	10.24	Yes	No	0	0	6
3	L:L:?1	R:R:S107	6.74	Yes	Yes	1	0	7
4	L:L:?1	R:R:T108	5.29	Yes	Yes	0	0	6
5	L:L:?1	R:R:L190	3.73	Yes	No	0	0	4
6	L:L:?1	R:R:S198	9.43	Yes	No	0	0	7
7	L:L:?1	R:R:F288	13.11	Yes	Yes	1	0	7
8	L:L:?1	R:R:F289	9.83	Yes	Yes	1	0	7
9	L:L:?1	R:R:N292	7.39	Yes	No	1	0	6
10	R:R:L30	R:R:T26	4.42	Yes	No	0	7	5
11	R:R:F29	R:R:L30	3.65	No	Yes	0	3	7
12	R:R:A82	R:R:L30	4.73	No	Yes	0	6	7
13	R:R:L30	R:R:W318	7.97	Yes	Yes	0	7	5
14	R:R:I34	R:R:M78	7.29	No	Yes	0	6	7
15	R:R:I34	R:R:P79	5.08	No	No	0	6	8
16	R:R:M78	R:R:T37	7.53	Yes	No	0	7	7
17	R:R:S325	R:R:T37	7.99	No	No	0	6	7
18	R:R:G40	R:R:P328	4.06	No	No	0	9	9
19	R:R:D70	R:R:N41	12.12	Yes	No	0	9	9
20	R:R:N41	R:R:P328	9.77	No	No	0	9	9
21	R:R:F341	R:R:L43	9.74	Yes	No	0	7	7
22	R:R:P328	R:R:V44	3.53	No	No	0	9	9
23	R:R:F341	R:R:V44	3.93	Yes	No	0	7	9
24	R:R:A47	R:R:F341	4.16	No	Yes	0	8	7
25	R:R:I64	R:R:V48	10.75	No	No	0	6	8
26	R:R:F51	R:R:H53	6.79	Yes	No	0	6	6
27	R:R:A340	R:R:F51	6.93	No	Yes	0	7	6
28	R:R:F51	R:R:T343	3.89	Yes	No	0	6	4
29	R:R:H53	R:R:L54	6.43	No	No	0	6	9
30	R:R:H53	R:R:K339	3.93	No	No	0	6	5
31	R:R:D336	R:R:L54	4.07	No	No	0	7	9
32	R:R:F337	R:R:L54	4.87	Yes	No	0	9	9
33	R:R:K57	R:R:S56	6.12	No	No	0	5	8
34	R:R:F62	R:R:V58	3.93	Yes	No	0	8	6
35	R:R:D120	R:R:T59	8.67	No	No	0	9	8
36	R:R:F337	R:R:N60	4.83	Yes	No	0	9	9
37	R:R:F141	R:R:F61	4.29	No	Yes	0	3	4
38	R:R:F62	R:R:V116	5.24	Yes	No	0	8	7
39	R:R:F62	R:R:I117	3.77	Yes	No	0	8	9
40	R:R:D120	R:R:F62	9.55	No	Yes	0	9	8
41	R:R:F62	R:R:L143	4.87	Yes	No	0	8	7
42	R:R:F62	R:R:I144	3.77	Yes	No	0	8	8
43	R:R:N113	R:R:S65	10.43	No	No	0	8	9
44	R:R:I144	R:R:S65	7.74	No	No	0	8	9
45	R:R:S65	R:R:W148	4.94	No	No	0	9	9
46	R:R:L66	R:R:N113	4.12	No	No	0	9	8
47	R:R:L114	R:R:L66	5.54	Yes	No	1	9	9
48	R:R:L66	R:R:N327	8.24	No	Yes	1	9	9
49	R:R:D70	R:R:S110	5.89	Yes	No	0	9	9
50	R:R:D70	R:R:S324	8.83	Yes	No	0	9	9
51	R:R:D70	R:R:N327	6.73	Yes	Yes	0	9	9
52	R:R:C106	R:R:L72	4.76	No	No	0	7	7
53	R:R:C106	R:R:V73	5.12	No	No	0	7	8
54	R:R:V73	R:R:W321	3.68	No	Yes	0	8	7
55	R:R:S324	R:R:V73	6.46	No	No	0	9	8
56	R:R:F102	R:R:L76	15.83	No	No	0	5	6
57	R:R:V77	R:R:W99	6.13	No	Yes	1	8	5
58	R:R:D103	R:R:V77	5.84	Yes	No	1	7	8
59	R:R:V77	R:R:W321	3.68	No	Yes	1	8	7
60	R:R:M78	R:R:W318	4.65	Yes	Yes	1	7	5
61	R:R:M78	R:R:W321	8.14	Yes	Yes	1	7	7
62	R:R:P79	R:R:W80	4.05	No	Yes	0	8	5
63	R:R:F92	R:R:W80	4.01	Yes	Yes	1	6	5
64	R:R:F95	R:R:W80	4.01	No	Yes	1	5	5
65	R:R:W80	R:R:W99	6.56	Yes	Yes	1	5	5
66	R:R:D314	R:R:K81	8.3	No	No	0	4	6
67	R:R:K81	R:R:W321	4.64	No	Yes	0	6	7
68	R:R:P91	R:R:V83	3.53	Yes	No	1	1	4
69	R:R:F92	R:R:V83	3.93	Yes	No	1	6	4
70	R:R:A84	R:R:W90	3.89	No	Yes	0	5	8
71	R:R:D314	R:R:E85	12.99	No	No	0	4	4
72	R:R:F89	R:R:P91	4.33	No	Yes	0	4	1
73	R:R:P91	R:R:W90	4.05	Yes	Yes	1	1	8
74	R:R:F92	R:R:W90	19.04	Yes	Yes	1	6	8
75	R:R:C96	R:R:W90	7.84	No	Yes	1	9	8
76	R:R:W90	R:R:W99	8.43	Yes	Yes	1	8	5
77	R:R:C186	R:R:W90	9.14	No	Yes	1	9	8
78	R:R:F92	R:R:P91	13	Yes	Yes	1	6	1
79	R:R:F95	R:R:W99	4.01	No	Yes	1	5	5
80	R:R:C186	R:R:C96	7.28	No	No	1	9	9
81	R:R:K165	R:R:N97	4.2	No	No	0	3	6
82	R:R:F102	R:R:I98	3.77	No	No	0	5	6
83	R:R:S188	R:R:V100	4.85	No	No	0	5	5
84	R:R:A101	R:R:V159	5.09	No	No	0	6	5
85	R:R:F102	R:R:F156	6.43	No	No	0	5	5
86	R:R:D103	R:R:S107	4.42	Yes	Yes	1	7	7
87	R:R:D103	R:R:W321	6.7	Yes	Yes	1	7	7
88	R:R:I104	R:R:Y194	8.46	No	Yes	0	6	7
89	R:R:M105	R:R:V152	4.56	No	No	0	5	4
90	R:R:M105	R:R:S155	6.13	No	No	0	5	7
91	R:R:S107	R:R:W285	3.71	Yes	Yes	1	7	8
92	R:R:S107	R:R:W321	4.94	Yes	Yes	1	7	7
93	R:R:S151	R:R:T108	4.8	No	Yes	0	8	6
94	R:R:S202	R:R:T108	9.59	No	Yes	0	6	6
95	R:R:A109	R:R:W148	7.78	No	No	0	7	9
96	R:R:I111	R:R:W285	7.05	No	Yes	0	8	8
97	R:R:F281	R:R:L114	3.65	No	Yes	1	9	9
98	R:R:L114	R:R:N327	6.87	Yes	Yes	1	9	9
99	R:R:L114	R:R:Y331	9.38	Yes	Yes	0	9	9
100	R:R:C115	R:R:P206	3.77	No	No	0	7	9
101	R:R:C115	R:R:I209	4.91	No	No	0	7	6
102	R:R:I117	R:R:Y331	4.84	No	Yes	0	9	9
103	R:R:M210	R:R:S118	6.13	No	No	0	8	8
104	R:R:S118	R:R:T213	6.4	No	No	0	8	7
105	R:R:V119	R:R:W123	3.68	No	No	0	6	4
106	R:R:D120	R:R:Y131	8.05	No	Yes	0	9	7
107	R:R:R121	R:R:Y214	8.23	No	Yes	0	9	9
108	R:R:R121	R:R:Y331	5.14	No	Yes	0	9	9
109	R:R:S126	R:R:Y122	12.72	No	No	0	7	8
110	R:R:T213	R:R:Y122	8.74	No	No	0	7	8
111	R:R:R216	R:R:Y122	14.4	No	No	0	5	8
112	R:R:W123	R:R:Y131	3.86	No	Yes	0	4	7
113	R:R:A124	R:R:Y131	9.34	No	Yes	0	8	7
114	R:R:I125	R:R:I217	4.42	No	No	0	8	9
115	R:R:S126	R:R:S127	4.89	No	No	0	7	6
116	R:R:R130	R:R:S127	3.95	No	No	0	5	6
117	R:R:K134	R:R:R130	4.95	No	No	0	5	5
118	R:R:M135	R:R:Y131	4.79	No	Yes	0	7	7
119	R:R:P137	R:R:T136	5.25	No	No	0	1	8
120	R:R:F156	R:R:S155	6.61	No	No	0	5	7
121	R:R:I157	R:R:P158	5.08	No	No	0	6	6
122	R:R:P158	R:R:W163	4.05	No	No	0	6	6
123	R:R:P158	R:R:Y194	5.56	No	Yes	0	6	7
124	R:R:H164	R:R:V159	8.3	Yes	No	0	5	5
125	R:R:L161	R:R:W163	11.39	No	No	0	4	6
126	R:R:H164	R:R:K165	11.79	Yes	No	0	5	3
127	R:R:D187	R:R:S189	10.31	No	No	0	5	4
128	R:R:S191	R:R:Y194	3.82	No	Yes	0	5	7
129	R:R:F297	R:R:R192	8.55	No	No	0	6	4
130	R:R:S198	R:R:Y194	12.72	No	Yes	0	7	7
131	R:R:A195	R:R:P296	3.74	No	No	0	5	5
132	R:R:S199	R:R:Y204	3.82	No	No	0	7	5
133	R:R:F289	R:R:S199	7.93	Yes	No	0	7	7
134	R:R:V200	R:R:Y204	3.79	No	No	0	4	5
135	R:R:F203	R:R:Y204	9.28	Yes	No	0	8	5
136	R:R:F203	R:R:V207	6.55	Yes	No	1	8	7
137	R:R:F203	R:R:F281	6.43	Yes	No	1	8	9
138	R:R:F203	R:R:L286	4.87	Yes	No	0	8	6
139	R:R:F203	R:R:F289	15	Yes	Yes	1	8	7
140	R:R:F281	R:R:V207	3.93	No	No	1	9	7
141	R:R:M210	R:R:M278	4.33	No	No	0	8	8
142	R:R:I211	R:R:M278	5.83	No	No	0	6	8
143	R:R:R216	R:R:V212	3.92	No	No	0	5	4
144	R:R:I217	R:R:Y214	4.84	No	Yes	0	9	9
145	R:R:I277	R:R:Y214	8.46	No	Yes	0	8	9
146	R:R:Q222	R:R:Y218	10.15	No	Yes	2	6	7
147	R:R:E267	R:R:Y218	11.22	No	Yes	2	8	7
148	R:R:Q222	R:R:R226	15.19	No	No	0	6	5
149	R:R:E267	R:R:Q222	14.02	No	No	2	8	6
150	R:R:I225	R:R:R266	6.26	No	No	0	5	6
151	R:R:L286	R:R:V282	4.47	No	No	0	6	7
152	R:R:C284	R:R:N323	6.3	No	No	0	9	9
153	R:R:F288	R:R:W285	4.01	Yes	Yes	1	7	8
154	R:R:F289	R:R:W285	7.02	Yes	Yes	1	7	8
155	R:R:G320	R:R:W285	11.26	No	Yes	0	7	8
156	R:R:N323	R:R:W285	10.17	No	Yes	0	9	8
157	R:R:F316	R:R:P287	5.78	Yes	No	0	5	9
158	R:R:F288	R:R:F289	5.36	Yes	Yes	1	7	7
159	R:R:F288	R:R:N292	13.29	Yes	No	1	7	6
160	R:R:F288	R:R:F313	4.29	Yes	Yes	1	7	4
161	R:R:F288	R:R:V317	5.24	Yes	No	1	7	6
162	R:R:I308	R:R:L291	5.71	No	Yes	0	4	5
163	R:R:F313	R:R:L291	4.87	Yes	Yes	0	4	5
164	R:R:F316	R:R:L291	6.09	Yes	Yes	0	5	5
165	R:R:F313	R:R:N292	3.62	Yes	No	1	4	6
166	R:R:L295	R:R:P296	8.21	No	No	0	3	5
167	R:R:F313	R:R:L295	6.09	Yes	No	0	4	3
168	R:R:C298	R:R:F306	6.98	No	No	0	4	1
169	R:R:I308	R:R:T312	7.6	No	No	0	4	4
170	R:R:D309	R:R:N311	5.39	No	No	0	4	1
171	R:R:N311	R:R:S310	4.47	No	No	0	1	1
172	R:R:F313	R:R:V317	5.24	Yes	No	1	4	6
173	R:R:D314	R:R:W318	5.58	No	Yes	0	4	5
174	R:R:F316	R:R:F319	4.29	Yes	No	0	5	7
175	R:R:V317	R:R:W321	6.13	No	Yes	1	6	7
176	R:R:W318	R:R:W321	12.18	Yes	Yes	1	5	7
177	R:R:N323	R:R:N327	9.54	No	Yes	0	9	9
178	R:R:F333	R:R:I329	6.28	No	No	0	8	7
179	R:R:I330	R:R:Y331	4.84	No	Yes	0	8	9
180	R:R:A332	R:R:F337	8.32	No	Yes	0	6	9
181	R:R:F333	R:R:F341	4.29	No	Yes	0	8	7
182	R:R:D336	R:R:N334	5.39	No	No	0	7	8
183	R:R:F337	R:R:N334	4.83	Yes	No	0	9	8
184	R:R:F337	R:R:F341	4.29	Yes	Yes	0	9	7
185	R:R:L274	R:R:Y214	3.52	No	Yes	0	8	9
186	R:R:L274	R:R:Y218	3.52	No	Yes	0	8	7
187	R:R:Q224	R:R:R227	3.5	No	No	0	7	5
188	R:R:G40	R:R:L39	3.42	No	No	0	9	4
189	R:R:A109	R:R:S69	3.42	No	No	0	7	8
190	R:R:A67	R:R:V44	3.39	No	No	0	9	9
191	R:R:I111	R:R:P206	3.39	No	No	0	8	9
192	R:R:I205	R:R:P206	3.39	No	No	0	5	9
193	R:R:A221	R:R:V270	3.39	No	No	0	9	8
194	R:R:A74	R:R:T37	3.36	No	No	0	7	7
195	R:R:H164	R:R:Y194	3.27	Yes	Yes	0	5	7
196	R:R:C293	R:R:I196	3.27	No	No	0	6	6
197	R:R:S325	R:R:S36	3.26	No	No	0	6	4
198	R:R:A27	R:R:I86	3.25	No	No	0	6	5
199	R:R:R130	R:R:R133	3.2	No	No	0	5	4
200	R:R:I104	R:R:S155	3.1	No	No	0	6	7
201	R:R:I117	R:R:V63	3.07	No	No	0	9	8
202	R:R:I330	R:R:V276	3.07	No	No	0	8	7
203	R:R:I86	R:R:T26	3.04	No	No	0	5	5
204	R:R:I217	R:R:T213	3.04	No	No	0	9	7
205	R:R:M278	R:R:V282	3.04	No	No	0	8	7
206	R:R:L76	R:R:V75	2.98	No	No	0	6	5
207	R:R:L274	R:R:V270	2.98	No	No	0	8	8
208	R:R:L112	R:R:T108	2.95	No	Yes	0	5	6
209	R:R:I125	R:R:I220	2.94	No	No	0	8	6
210	R:R:I294	R:R:L291	2.85	No	Yes	0	5	5
211	R:R:G93	R:R:W90	2.81	No	Yes	0	7	8
212	R:R:K57	R:R:N60	2.8	No	No	0	5	9
213	R:R:L38	R:R:L71	2.77	No	No	0	7	8
214	R:R:A87	R:R:F89	2.77	No	No	0	5	4
215	R:R:H164	R:R:V100	2.77	Yes	No	0	5	5
216	R:R:D187	R:R:K165	2.77	No	No	0	5	3
217	R:R:L71	R:R:N41	2.75	No	No	0	8	9
218	R:R:I98	R:R:Q160	2.74	No	No	0	6	5
219	R:R:F337	R:R:V48	2.62	Yes	No	0	9	8
220	R:R:F264	R:R:T268	2.59	No	No	0	5	5
221	R:R:K223	R:R:R227	2.48	No	No	0	5	5
222	R:R:F29	R:R:L33	2.44	No	No	0	3	7
223	R:R:F51	R:R:L344	2.44	Yes	No	0	6	6
224	R:R:L344	R:R:R50	2.43	No	No	0	6	6
225	R:R:E132	R:R:F129	2.33	No	No	0	5	7
226	R:R:E232	R:R:R266	2.33	No	No	0	3	6
227	R:R:F61	R:R:R55	2.14	Yes	No	0	4	8
228	R:R:F333	R:R:R338	2.14	No	No	0	8	8
229	R:R:R52	R:R:R55	2.13	No	No	0	7	8
230	R:R:R219	R:R:Y218	2.06	No	Yes	0	4	7
231	R:R:C307	R:R:G299	1.96	No	No	0	3	1
232	R:R:C298	R:R:C307	1.82	No	No	0	4	3
233	R:R:P128	R:R:S127	1.78	No	No	0	8	6
234	R:R:A166	R:R:S191	1.71	No	No	0	2	5
235	R:R:C284	R:R:V280	1.71	No	No	0	9	7
236	R:R:G346	R:R:L345	1.71	No	No	0	5	7
237	R:R:A140	R:R:V58	1.7	No	No	0	7	6
238	R:R:A147	R:R:V116	1.7	No	No	0	7	7
239	R:R:C45	R:R:I49	1.64	No	No	0	7	4
240	R:R:C293	R:R:I290	1.64	No	No	0	6	7
241	R:R:S145	R:R:T149	1.6	No	No	0	4	3
242	R:R:T26	R:R:V22	1.59	No	No	0	5	4
243	R:R:C28	R:R:L25	1.59	No	No	0	5	4
244	R:R:A46	R:R:L344	1.58	No	No	0	5	6
245	R:R:I154	R:R:S198	1.55	No	No	0	5	7
246	R:R:I49	R:R:V48	1.54	No	No	0	4	8
247	R:R:I196	R:R:V200	1.54	No	No	0	6	4
248	R:R:I277	R:R:T273	1.52	No	No	0	8	9
249	R:R:K138	R:R:T136	1.5	No	No	0	4	8
250	R:R:K269	R:R:T273	1.5	No	No	0	8	9
251	R:R:K272	R:R:T273	1.5	No	No	0	7	9
252	R:R:L326	R:R:V280	1.49	No	No	0	6	7
253	R:R:N240	R:R:V236	1.48	No	No	0	4	4
254	R:R:L71	R:R:T42	1.47	No	No	0	8	5
255	R:R:F61	R:R:P137	1.44	Yes	No	0	4	1
256	R:R:I24	R:R:L25	1.43	No	No	0	6	4
257	R:R:I157	R:R:L153	1.43	No	No	0	6	4
258	R:R:A140	R:R:F61	1.39	No	Yes	0	7	4
259	R:R:L345	R:R:L43	1.38	No	No	0	7	7
260	R:R:A229	R:R:R233	1.38	No	No	0	4	1
261	R:R:E267	R:R:I225	1.37	No	No	0	8	5
262	R:R:F316	R:R:V315	1.31	Yes	No	0	5	4
263	R:R:R216	R:R:T215	1.29	No	No	0	5	3
264	R:R:R219	R:R:T215	1.29	No	No	0	4	3
265	R:R:H237	R:R:N240	1.28	No	No	0	1	4
266	R:R:V68	R:R:W148	1.23	No	No	0	6	9
267	R:R:L271	R:R:Y218	1.17	No	Yes	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.66	9	1	0
2	R:R:L30	5.1925	4	0	7
3	R:R:F51	5.0125	4	0	6
4	R:R:F61	2.315	4	0	4
5	R:R:F62	5.18833	6	0	8
6	R:R:D70	8.3925	4	0	9
7	R:R:M78	6.9025	4	1	7
8	R:R:W80	4.6575	4	1	5
9	R:R:W90	7.88571	7	1	8
10	R:R:P91	6.2275	4	1	1
11	R:R:F92	9.995	4	1	6
12	R:R:W99	6.2825	4	1	5
13	R:R:D103	7.285	4	1	7
14	R:R:S107	4.9525	4	1	7
15	R:R:T108	5.6575	4	0	6
16	R:R:L114	6.36	4	1	9
17	R:R:Y131	6.51	4	0	7
18	R:R:H164	6.5325	4	0	5
19	R:R:Y194	6.766	5	0	7
20	R:R:F203	8.426	5	1	8
21	R:R:Y214	6.2625	4	0	9
22	R:R:Y218	5.624	5	2	7
23	R:R:W285	7.20333	6	1	8
24	R:R:F288	7.55	6	1	7
25	R:R:F289	9.028	5	1	7
26	R:R:L291	4.88	4	0	5
27	R:R:F313	4.822	5	1	4
28	R:R:F316	4.3675	4	0	5
29	R:R:W318	7.595	4	1	5
30	R:R:W321	6.26125	8	1	7
31	R:R:N327	7.845	4	1	9
32	R:R:Y331	6.05	4	0	9
33	R:R:F337	4.96	6	0	9
34	R:R:F341	5.282	5	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	41.114	12.18	Yes	Yes	1	0	7
2	R:R:D103	R:R:W321	26.1088	6.7	Yes	Yes	1	7	7
3	R:R:W318	R:R:W321	30.5625	12.18	Yes	Yes	1	5	7
4	R:R:L30	R:R:W318	22.9679	7.97	Yes	Yes	0	7	5
5	R:R:L30	R:R:T26	11.6251	4.42	Yes	No	0	7	5
6	L:L:?1	R:R:S107	45.5309	6.74	Yes	Yes	1	0	7
7	R:R:S107	R:R:W321	48.6657	4.94	Yes	Yes	1	7	7
8	R:R:M78	R:R:W321	19.1215	8.14	Yes	Yes	1	7	7
9	R:R:D103	R:R:V77	21.7901	5.84	Yes	No	1	7	8
10	R:R:V77	R:R:W99	40.4822	6.13	No	Yes	1	8	5
11	R:R:M78	R:R:T37	11.5269	7.53	Yes	No	0	7	7
12	R:R:V73	R:R:W321	59.3829	3.68	No	Yes	0	8	7
13	R:R:S324	R:R:V73	56.8922	6.46	No	No	0	9	8
14	R:R:D70	R:R:S324	56.61	8.83	Yes	No	0	9	9
15	R:R:D70	R:R:N41	100	12.12	Yes	No	0	9	9
16	R:R:N41	R:R:P328	90.3073	9.77	No	No	0	9	9
17	R:R:S107	R:R:W285	49.954	3.71	Yes	Yes	1	7	8
18	R:R:N323	R:R:W285	89.0129	10.17	No	Yes	0	9	8
19	R:R:N323	R:R:N327	85.4549	9.54	No	Yes	0	9	9
20	R:R:D70	R:R:N327	81.8845	6.73	Yes	Yes	0	9	9
21	L:L:?1	R:R:F288	23.8636	13.11	Yes	Yes	1	0	7
22	R:R:F288	R:R:W285	28.9062	4.01	Yes	Yes	1	7	8
23	L:L:?1	R:R:F289	66.3456	9.83	Yes	Yes	1	0	7
24	R:R:F289	R:R:W285	26.3235	7.02	Yes	Yes	1	7	8
25	R:R:P328	R:R:V44	82.909	3.53	No	No	0	9	9
26	R:R:F341	R:R:V44	77.9155	3.93	Yes	No	0	7	9
27	R:R:F337	R:R:F341	57.4505	4.29	Yes	Yes	0	9	7
28	R:R:F337	R:R:V48	11.3551	2.62	Yes	No	0	9	8
29	R:R:F337	R:R:L54	27.9615	4.87	Yes	No	0	9	9
30	R:R:H53	R:R:L54	22.5201	6.43	No	No	0	6	9
31	R:R:F51	R:R:H53	16.9622	6.79	Yes	No	0	6	6
32	R:R:F203	R:R:F289	58.0455	15	Yes	Yes	1	8	7
33	R:R:F203	R:R:F281	36.4027	6.43	Yes	No	1	8	9
34	R:R:F281	R:R:L114	36.6051	3.65	No	Yes	1	9	9
35	R:R:L114	R:R:Y331	86.0438	9.38	Yes	Yes	0	9	9
36	R:R:I117	R:R:Y331	43.3225	4.84	No	Yes	0	9	9
37	R:R:F62	R:R:I117	39.8626	3.77	Yes	No	0	8	9
38	R:R:F62	R:R:V58	18.1584	3.93	Yes	No	0	8	6
39	R:R:D120	R:R:F62	14.2077	9.55	No	Yes	0	9	8
40	R:R:A140	R:R:V58	16.1892	1.7	No	No	0	7	6
41	R:R:A140	R:R:F61	14.2077	1.39	No	Yes	0	7	4
42	R:R:L66	R:R:N327	15.9929	8.24	No	Yes	1	9	9
43	R:R:L66	R:R:N113	18.4529	4.12	No	No	0	9	8
44	R:R:N113	R:R:S65	15.9622	10.43	No	No	0	8	9
45	R:R:S65	R:R:W148	12.0913	4.94	No	No	0	9	9
46	L:L:?1	R:R:I104	75.3144	10.24	Yes	No	0	0	6
47	R:R:I104	R:R:S155	26.2745	3.1	No	No	0	6	7
48	R:R:F156	R:R:S155	17.6247	6.61	No	No	0	5	7
49	R:R:F102	R:R:F156	14.7169	6.43	No	No	0	5	5
50	R:R:W90	R:R:W99	27.71	8.43	Yes	Yes	1	8	5
51	R:R:P91	R:R:W90	10.165	4.05	Yes	Yes	1	1	8
52	R:R:I104	R:R:Y194	48.5062	8.46	No	Yes	0	6	7
53	R:R:H164	R:R:Y194	51.23	3.27	Yes	Yes	0	5	7
54	R:R:H164	R:R:K165	22.8882	11.79	Yes	No	0	5	3
55	L:L:?1	R:R:S198	53.0336	9.43	Yes	No	0	0	7
56	R:R:S198	R:R:Y194	47.6719	12.72	No	Yes	0	7	7
57	R:R:H164	R:R:V100	11.4656	2.77	Yes	No	0	5	5
58	R:R:H164	R:R:V159	11.4656	8.3	Yes	No	0	5	5
59	L:L:?1	R:R:T108	12.1036	5.29	Yes	Yes	0	0	6
60	R:R:I111	R:R:W285	11.5882	7.05	No	Yes	0	8	8
61	R:R:F203	R:R:L286	22.5569	4.87	Yes	No	0	8	6
62	R:R:L286	R:R:V282	20.8024	4.47	No	No	0	6	7
63	R:R:M278	R:R:V282	19.2381	3.04	No	No	0	8	7
64	R:R:M210	R:R:M278	16.0972	4.33	No	No	0	8	8
65	R:R:M210	R:R:S118	14.8334	6.13	No	No	0	8	8
66	R:R:S118	R:R:T213	14.2445	6.4	No	No	0	8	7
67	R:R:D120	R:R:Y131	10.208	8.05	No	Yes	0	9	7
68	R:R:R121	R:R:Y331	50.3773	5.14	No	Yes	0	9	9
69	R:R:R121	R:R:Y214	48.7148	8.23	No	Yes	0	9	9
70	R:R:T213	R:R:Y122	20.2442	8.74	No	No	0	7	8
71	R:R:S126	R:R:Y122	13.539	12.72	No	No	0	7	8
72	R:R:I217	R:R:Y214	16.41	4.84	No	Yes	0	9	9
73	R:R:S126	R:R:S127	11.3122	4.89	No	No	0	7	6
74	R:R:P158	R:R:Y194	28.5811	5.56	No	Yes	0	6	7
75	R:R:I157	R:R:P158	11.4656	5.08	No	No	0	6	6
76	R:R:P158	R:R:W163	11.4656	4.05	No	No	0	6	6
77	R:R:D187	R:R:K165	11.4656	2.77	No	No	0	5	3
78	R:R:S191	R:R:Y194	11.4656	3.82	No	Yes	0	5	7
79	R:R:F288	R:R:F313	17.956	4.29	Yes	Yes	1	7	4
80	R:R:F203	R:R:Y204	10.2816	9.28	Yes	No	0	8	5
81	R:R:V200	R:R:Y204	12.8274	3.79	No	No	0	4	5
82	R:R:L274	R:R:Y214	25.3727	3.52	No	Yes	0	8	9
83	R:R:L274	R:R:Y218	19.5755	3.52	No	Yes	0	8	7
84	R:R:F313	R:R:L291	19.0847	4.87	Yes	Yes	0	4	5
85	R:R:L114	R:R:N327	59.2356	6.87	Yes	Yes	1	9	9
86	R:R:V317	R:R:W321	11.8827	6.13	No	Yes	1	6	7
87	R:R:V77	R:R:W321	21.0355	3.68	No	Yes	1	8	7
88	R:R:I217	R:R:T213	10.7969	3.04	No	No	0	9	7
89	R:R:F288	R:R:F289	11.9195	5.36	Yes	Yes	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D103	12.18	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:I104	10.24	1	Yes	No	0	6	0	1
L:L:?1	R:R:S107	6.74	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:T108	5.29	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L190	3.73	1	Yes	No	0	4	0	1
L:L:?1	R:R:S198	9.43	1	Yes	No	0	7	0	1
L:L:?1	R:R:F288	13.11	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F289	9.83	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N292	7.39	1	Yes	No	0	6	0	1
R:R:D103	R:R:V77	5.84	1	Yes	No	7	8	1	2
R:R:V77	R:R:W321	3.68	1	No	Yes	8	7	2	2
R:R:D103	R:R:S107	4.42	1	Yes	Yes	7	7	1	1
R:R:D103	R:R:W321	6.7	1	Yes	Yes	7	7	1	2
R:R:I104	R:R:Y194	8.46	0	No	Yes	6	7	1	2
R:R:S107	R:R:W285	3.71	1	Yes	Yes	7	8	1	2
R:R:S107	R:R:W321	4.94	1	Yes	Yes	7	7	1	2
R:R:S151	R:R:T108	4.8	0	No	Yes	8	6	2	1
R:R:S202	R:R:T108	9.59	0	No	Yes	6	6	2	1
R:R:S198	R:R:Y194	12.72	0	No	Yes	7	7	1	2
R:R:F289	R:R:S199	7.93	1	Yes	No	7	7	1	2
R:R:F203	R:R:F289	15	1	Yes	Yes	8	7	2	1
R:R:F288	R:R:W285	4.01	1	Yes	Yes	7	8	1	2
R:R:F289	R:R:W285	7.02	1	Yes	Yes	7	8	1	2
R:R:F288	R:R:F289	5.36	1	Yes	Yes	7	7	1	1
R:R:F288	R:R:N292	13.29	1	Yes	No	7	6	1	1
R:R:F288	R:R:F313	4.29	1	Yes	Yes	7	4	1	2
R:R:F288	R:R:V317	5.24	1	Yes	No	7	6	1	2
R:R:F313	R:R:N292	3.62	1	Yes	No	4	6	2	1
R:R:F313	R:R:V317	5.24	1	Yes	No	4	6	2	2
R:R:V317	R:R:W321	6.13	1	No	Yes	6	7	2	2
R:R:I104	R:R:S155	3.1	0	No	No	6	7	1	2
R:R:L112	R:R:T108	2.95	0	No	Yes	5	6	2	1
R:R:I154	R:R:S198	1.55	0	No	No	5	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F0T_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	249
Number of Links	267
Number of Hubs	34
Number of Links mediated by Hubs	131
Number of Communities	2
Number of Nodes involved in Communities	31
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	51678
Length Of Smallest Path	3
Average Path Length	12.0917
Length of Longest Path	23
Minimum Path Strength	1.29
Average Path Strength	6.75745
Maximum Path Strength	14.605
Minimum Path Correlation	0.7
Average Path Correlation	0.943328
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	6.25
Average % Of Corr. Nodes	61.5385
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.9508
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	LDP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	LDP
Name	Dopamine
Synonyms	4-(2-Aminoethyl)benzene-1,2-diol
Identifier
Formula	C8 H11 N O2
Molecular Weight	153.178
SMILES
PubChem	681
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	0
Total Bonds	22
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21728
Sequence	>7F0T_nogp_Chain_R S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F R H L R S K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G F W P F G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S P F R Y E R K M T P K A A F I L I S V A W T L S V L I S F I P V Q L S W H K A K D N C D S S L S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C G F C I D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F R K A F S T L L G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9JF4	A	Peptide	Bombesin	BB₁	Homo sapiens	PD168368	-	-	3.6	2025-07-09	To be published
	7W41	A	Peptide	Bombesin	BB₂	Homo sapiens	PD176252	-	-	2.95	2023-02-22	doi.org/10.1073/pnas.2216230120
	7CKZ	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7LJC	A	Amine	Dopamine	D₁	Homo sapiens	SKF-81297	Mevidalen	Gs/β1/γ2	3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJC (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF-81297	Mevidalen		3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ1	3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7X2F	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2F (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7F1O	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg	Gs/β1/γ2	3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1O (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg		3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7X2C	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam	Gs/β1/γ2	3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7X2C (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam		3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7JV5	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JV5 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7CKW	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKW (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-		3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-	Gs/β1/γ2	3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-		3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-	Gs/β1/γ2	3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-		3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	8IRR	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-	Gs/β1/γ2	3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8IRR (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-		3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	7JOZ	A	Amine	Dopamine	D₁	Homo sapiens	VFP	-	Gs/β1/γ2	3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7JOZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	VFP	-		3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7X2D	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-	Gs/β1/γ2	3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2D (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-		3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7F0T	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-	Gs/β1/γ2	3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F0T (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-		3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	8JXR	A	Amine	Dopamine	D₁	Homo sapiens	LSD	-	-	3.57	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8JXS	A	Amine	Dopamine	D₁	Homo sapiens	PF-6142	-	-	3	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	7CMV	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-	Gi1/β1/γ2	2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7CMV (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-		2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	8JD1	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	-	-	3.7	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	4NTJ	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	AZD1283	-	-	2.62	2014-03-26	doi.org/10.1038/nature13083
	7AD3	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	Gi1/STE4/γ2	3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7AD3 (No Gprot)	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-		3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7QA8	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	Peptide	-	-	2.7	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QB9	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	-	-	-	3.1	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBC	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.53	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBI	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.46	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	9V0U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9V0U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9I52	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-	Gs/β1/γ2	2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I52 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-		2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54	A	Amine	Dopamine	D₁	Homo sapiens	A1IZV	-	Gs/β1/γ2	2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A1IZV	-		2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

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