psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L25	R:R:V22	5.96	No	No	0	4	4
2	R:R:F29	R:R:L33	7.31	No	No	0	3	7
3	R:R:A82	R:R:L30	4.73	No	Yes	0	6	7
4	R:R:L30	R:R:W318	6.83	Yes	Yes	0	7	5
5	R:R:I34	R:R:M78	5.83	No	Yes	0	6	7
6	R:R:S325	R:R:S36	4.89	No	No	0	6	4
7	R:R:N41	R:R:T37	4.39	Yes	Yes	0	9	7
8	R:R:A74	R:R:T37	3.36	No	Yes	0	7	7
9	R:R:M78	R:R:T37	4.52	Yes	Yes	0	7	7
10	R:R:S325	R:R:T37	7.99	No	Yes	0	6	7
11	R:R:L39	R:R:L43	5.54	No	No	0	4	7
12	R:R:D70	R:R:N41	8.08	Yes	Yes	0	9	9
13	R:R:L71	R:R:N41	4.12	No	Yes	0	8	9
14	R:R:N41	R:R:P328	4.89	Yes	No	0	9	9
15	R:R:F341	R:R:L43	3.65	Yes	No	0	7	7
16	R:R:A67	R:R:V44	3.39	No	Yes	0	9	9
17	R:R:A332	R:R:V44	3.39	No	Yes	0	6	9
18	R:R:F341	R:R:V44	5.24	Yes	Yes	0	7	9
19	R:R:I64	R:R:V48	7.68	No	No	0	6	8
20	R:R:F51	R:R:R50	4.28	Yes	No	0	6	6
21	R:R:F51	R:R:H53	10.18	Yes	No	0	6	6
22	R:R:A340	R:R:F51	4.16	No	Yes	0	7	6
23	R:R:F51	R:R:L344	3.65	Yes	No	0	6	6
24	R:R:H53	R:R:L54	3.86	No	No	0	6	9
25	R:R:F337	R:R:L54	7.31	Yes	No	0	9	9
26	R:R:K57	R:R:N60	4.2	No	No	0	5	9
27	R:R:D336	R:R:K57	4.15	No	No	0	7	5
28	R:R:P137	R:R:V58	3.53	No	No	0	1	6
29	R:R:D120	R:R:T59	5.78	Yes	No	2	9	8
30	R:R:T59	R:R:Y131	3.75	No	Yes	2	8	7
31	R:R:F337	R:R:N60	6.04	Yes	No	0	9	9
32	R:R:F141	R:R:F61	5.36	No	No	0	3	4
33	R:R:F62	R:R:V116	5.24	Yes	No	0	8	7
34	R:R:F62	R:R:I117	3.77	Yes	No	0	8	9
35	R:R:D120	R:R:F62	10.75	Yes	Yes	0	9	8
36	R:R:F62	R:R:L143	4.87	Yes	No	0	8	7
37	R:R:F62	R:R:I144	3.77	Yes	No	0	8	8
38	R:R:N113	R:R:S65	8.94	No	No	0	8	9
39	R:R:I144	R:R:S65	4.64	No	No	0	8	9
40	R:R:D70	R:R:L66	5.43	Yes	Yes	1	9	9
41	R:R:L114	R:R:L66	5.54	Yes	Yes	1	9	9
42	R:R:L66	R:R:N327	6.87	Yes	No	1	9	9
43	R:R:L66	R:R:Y331	3.52	Yes	Yes	1	9	9
44	R:R:A109	R:R:S69	3.42	No	No	3	7	8
45	R:R:S69	R:R:W148	4.94	No	No	3	8	9
46	R:R:D70	R:R:S110	5.89	Yes	No	0	9	9
47	R:R:D70	R:R:S324	11.78	Yes	No	0	9	9
48	R:R:D70	R:R:N327	6.73	Yes	No	1	9	9
49	R:R:V73	R:R:V77	3.21	No	Yes	0	8	8
50	R:R:C106	R:R:V73	5.12	No	No	0	7	8
51	R:R:S324	R:R:V73	4.85	No	No	0	9	8
52	R:R:F102	R:R:L76	12.18	Yes	No	0	5	6
53	R:R:V77	R:R:W99	4.9	Yes	Yes	1	8	5
54	R:R:D103	R:R:V77	4.38	Yes	Yes	1	7	8
55	R:R:V77	R:R:W321	4.9	Yes	Yes	1	8	7
56	R:R:M78	R:R:W318	5.82	Yes	Yes	1	7	5
57	R:R:M78	R:R:W321	5.82	Yes	Yes	1	7	7
58	R:R:P79	R:R:W80	4.05	No	Yes	0	8	5
59	R:R:F92	R:R:W80	8.02	Yes	Yes	1	6	5
60	R:R:F95	R:R:W80	8.02	Yes	Yes	1	5	5
61	R:R:W80	R:R:W99	5.62	Yes	Yes	1	5	5
62	R:R:E85	R:R:K81	5.4	No	Yes	1	4	6
63	R:R:K81	R:R:W99	6.96	Yes	Yes	1	6	5
64	R:R:K81	R:R:W318	6.96	Yes	Yes	1	6	5
65	R:R:K81	R:R:W321	4.64	Yes	Yes	1	6	7
66	L:L:?1	R:R:K81	5.45	Yes	Yes	1	0	6
67	R:R:F92	R:R:V83	5.24	Yes	No	0	6	4
68	R:R:A84	R:R:W90	3.89	No	Yes	0	5	8
69	R:R:D314	R:R:E85	11.69	No	No	0	4	4
70	R:R:E85	R:R:W318	4.36	No	Yes	1	4	5
71	R:R:F89	R:R:P91	5.78	No	No	0	4	1
72	R:R:P91	R:R:W90	4.05	No	Yes	1	1	8
73	R:R:F92	R:R:W90	20.04	Yes	Yes	1	6	8
74	R:R:F95	R:R:W90	4.01	Yes	Yes	1	5	8
75	R:R:C96	R:R:W90	6.53	No	Yes	1	9	8
76	R:R:W90	R:R:W99	3.75	Yes	Yes	1	8	5
77	R:R:C186	R:R:W90	14.37	No	Yes	1	9	8
78	R:R:F92	R:R:P91	7.22	Yes	No	1	6	1
79	R:R:F92	R:R:F95	3.22	Yes	Yes	1	6	5
80	R:R:F95	R:R:I98	6.28	Yes	No	1	5	6
81	R:R:F102	R:R:F95	3.22	Yes	Yes	1	5	5
82	R:R:C186	R:R:C96	5.46	No	No	1	9	9
83	R:R:H164	R:R:N97	6.38	No	No	0	5	6
84	R:R:F102	R:R:I98	5.02	Yes	No	1	5	6
85	R:R:I98	R:R:Q160	4.12	No	No	0	6	5
86	R:R:V100	R:R:W99	3.68	No	Yes	1	5	5
87	R:R:W321	R:R:W99	4.69	Yes	Yes	1	7	5
88	L:L:?1	R:R:W99	7.34	Yes	Yes	1	0	5
89	L:L:?1	R:R:V100	7.68	Yes	No	1	0	5
90	R:R:A101	R:R:V159	5.09	No	No	0	6	5
91	R:R:F102	R:R:F156	4.29	Yes	Yes	1	5	5
92	R:R:D103	R:R:S107	4.42	Yes	Yes	1	7	7
93	R:R:D103	R:R:W321	11.17	Yes	Yes	1	7	7
94	L:L:?1	R:R:D103	13.12	Yes	Yes	1	0	7
95	R:R:I104	R:R:Y194	3.63	No	Yes	0	6	7
96	L:L:?1	R:R:I104	14.72	Yes	No	0	0	6
97	R:R:C106	R:R:M105	3.24	No	No	0	7	5
98	R:R:M105	R:R:S155	4.6	No	No	0	5	7
99	R:R:S107	R:R:W285	4.94	Yes	Yes	1	7	8
100	R:R:S107	R:R:W321	4.94	Yes	Yes	1	7	7
101	L:L:?1	R:R:S107	3.87	Yes	Yes	1	0	7
102	R:R:S151	R:R:T108	3.2	No	No	0	8	6
103	R:R:S202	R:R:T108	9.59	No	No	0	6	6
104	R:R:A109	R:R:W148	7.78	No	No	3	7	9
105	R:R:A109	R:R:S151	3.42	No	No	0	7	8
106	R:R:I111	R:R:P206	3.39	No	No	0	8	9
107	R:R:F281	R:R:I111	3.77	Yes	No	1	9	8
108	R:R:I111	R:R:W285	12.92	No	Yes	1	8	8
109	R:R:L112	R:R:L150	4.15	No	No	0	5	4
110	R:R:N113	R:R:W148	5.65	No	No	0	8	9
111	R:R:F281	R:R:L114	3.65	Yes	Yes	1	9	9
112	R:R:L114	R:R:N327	9.61	Yes	No	1	9	9
113	R:R:L114	R:R:Y331	4.69	Yes	Yes	1	9	9
114	R:R:C115	R:R:P206	3.77	No	No	0	7	9
115	R:R:C115	R:R:I209	4.91	No	No	0	7	6
116	R:R:I117	R:R:R121	5.01	No	No	1	9	9
117	R:R:I117	R:R:Y331	4.84	No	Yes	1	9	9
118	R:R:M210	R:R:S118	7.67	No	No	0	8	8
119	R:R:S118	R:R:T213	3.2	No	No	0	8	7
120	R:R:S118	R:R:Y214	10.17	No	Yes	0	8	9
121	R:R:V119	R:R:W123	7.36	No	No	0	6	4
122	R:R:D120	R:R:Y131	10.34	Yes	Yes	2	9	7
123	R:R:D120	R:R:M135	4.16	Yes	Yes	2	9	7
124	R:R:R121	R:R:Y214	8.23	No	Yes	0	9	9
125	R:R:R121	R:R:Y331	6.17	No	Yes	1	9	9
126	R:R:S126	R:R:Y122	13.99	No	Yes	0	7	8
127	R:R:T213	R:R:Y122	7.49	No	Yes	0	7	8
128	R:R:R216	R:R:Y122	10.29	No	Yes	0	5	8
129	R:R:A124	R:R:Y131	8.01	No	Yes	0	8	7
130	R:R:I125	R:R:I217	4.42	No	No	0	8	9
131	R:R:S126	R:R:S127	3.26	No	No	0	7	6
132	R:R:R130	R:R:S127	9.22	No	No	0	5	6
133	R:R:K134	R:R:R130	4.95	No	No	0	5	5
134	R:R:M135	R:R:Y131	9.58	Yes	Yes	2	7	7
135	R:R:P137	R:R:T136	3.5	No	No	0	1	8
136	R:R:S155	R:R:V152	3.23	No	No	1	7	4
137	R:R:F156	R:R:V152	3.93	Yes	No	1	5	4
138	R:R:F156	R:R:S155	3.96	Yes	No	1	5	7
139	R:R:I157	R:R:P158	3.39	No	No	0	6	6
140	R:R:P158	R:R:Y194	9.74	No	Yes	0	6	7
141	R:R:H164	R:R:V159	12.45	No	No	0	5	5
142	R:R:L161	R:R:W163	5.69	No	No	0	4	6
143	R:R:H164	R:R:K165	10.48	No	No	0	5	3
144	R:R:D187	R:R:N185	8.08	No	No	0	5	4
145	L:L:?1	R:R:L190	15.16	Yes	No	0	0	4
146	R:R:S198	R:R:Y194	8.9	No	Yes	0	7	7
147	R:R:A195	R:R:N292	4.69	No	No	0	5	6
148	R:R:C293	R:R:I196	3.27	No	No	0	6	6
149	L:L:?1	R:R:S198	7.74	Yes	No	0	0	7
150	R:R:F289	R:R:S199	5.28	Yes	No	0	7	7
151	R:R:N292	R:R:S199	4.47	No	No	0	6	7
152	R:R:C293	R:R:S199	3.44	No	No	0	6	7
153	R:R:F203	R:R:Y204	6.19	Yes	No	0	8	5
154	R:R:F203	R:R:V207	9.18	Yes	No	0	8	7
155	R:R:F203	R:R:F281	8.57	Yes	Yes	1	8	9
156	R:R:F203	R:R:W285	5.01	Yes	Yes	1	8	8
157	R:R:F203	R:R:L286	4.87	Yes	No	0	8	6
158	R:R:F203	R:R:F289	22.51	Yes	Yes	1	8	7
159	R:R:C293	R:R:Y204	5.38	No	No	0	6	5
160	R:R:I205	R:R:P206	3.39	No	No	0	5	9
161	R:R:M210	R:R:M278	4.33	No	No	0	8	8
162	R:R:F281	R:R:M210	6.22	Yes	No	0	9	8
163	R:R:I211	R:R:M278	4.37	No	No	0	6	8
164	R:R:R216	R:R:V212	5.23	No	No	0	5	4
165	R:R:L274	R:R:Y214	4.69	No	Yes	0	8	9
166	R:R:I277	R:R:Y214	3.63	No	Yes	0	8	9
167	R:R:M278	R:R:Y214	4.79	No	Yes	0	8	9
168	R:R:R219	R:R:T215	3.88	No	No	0	4	3
169	R:R:Q222	R:R:Y218	20.29	No	Yes	0	6	7
170	R:R:L271	R:R:Y218	3.52	No	Yes	0	7	7
171	R:R:L274	R:R:Y218	3.52	No	Yes	0	8	7
172	R:R:A221	R:R:V270	3.39	No	No	0	9	8
173	R:R:E267	R:R:Q222	8.92	No	No	0	8	6
174	R:R:I225	R:R:R266	3.76	No	No	0	5	6
175	R:R:I228	R:R:R266	5.01	No	No	0	7	6
176	R:R:E232	R:R:R266	5.82	No	No	0	3	6
177	R:R:E267	R:R:T268	5.64	No	No	0	8	5
178	R:R:I277	R:R:I330	4.42	No	No	0	8	8
179	R:R:I330	R:R:V280	4.61	No	No	0	8	7
180	R:R:F281	R:R:V282	3.93	Yes	No	0	9	7
181	R:R:F281	R:R:W285	8.02	Yes	Yes	1	9	8
182	R:R:C284	R:R:N323	6.3	No	No	0	9	9
183	R:R:F288	R:R:W285	7.02	Yes	Yes	1	7	8
184	R:R:F289	R:R:W285	8.02	Yes	Yes	1	7	8
185	R:R:G320	R:R:W285	5.63	No	Yes	1	7	8
186	R:R:N323	R:R:W285	15.82	No	Yes	1	9	8
187	R:R:L286	R:R:P287	3.28	No	No	0	6	9
188	R:R:F316	R:R:P287	4.33	No	No	0	5	9
189	R:R:F288	R:R:F289	10.72	Yes	Yes	1	7	7
190	R:R:F288	R:R:F313	4.29	Yes	No	0	7	4
191	R:R:F288	R:R:V317	5.24	Yes	No	0	7	6
192	L:L:?1	R:R:F288	14.91	Yes	Yes	1	0	7
193	L:L:?1	R:R:F289	5.49	Yes	Yes	1	0	7
194	R:R:L291	R:R:L295	4.15	Yes	No	0	5	3
195	R:R:I308	R:R:L291	9.99	No	Yes	0	4	5
196	R:R:F313	R:R:L291	8.53	No	Yes	0	4	5
197	R:R:F316	R:R:L291	7.31	No	Yes	0	5	5
198	L:L:?1	R:R:N292	5.31	Yes	No	0	0	6
199	R:R:I308	R:R:T312	4.56	No	No	0	4	4
200	R:R:F316	R:R:T312	5.19	No	No	0	5	4
201	R:R:V317	R:R:W321	7.36	No	Yes	0	6	7
202	R:R:W318	R:R:W321	4.69	Yes	Yes	1	5	7
203	R:R:G320	R:R:N323	5.09	No	No	1	7	9
204	R:R:F333	R:R:I329	6.28	No	No	0	8	7
205	R:R:I330	R:R:Y331	8.46	No	Yes	0	8	9
206	R:R:A332	R:R:F337	4.16	No	Yes	0	6	9
207	R:R:F333	R:R:F341	6.43	No	Yes	0	8	7
208	R:R:A322	R:R:L33	3.15	No	No	0	4	7
209	R:R:A74	R:R:L38	3.15	No	No	0	7	7
210	R:R:I201	R:R:S197	3.1	No	No	0	4	4
211	R:R:I205	R:R:V200	3.07	No	No	0	5	4
212	R:R:I225	R:R:V270	3.07	No	No	0	5	8
213	R:R:K57	R:R:S56	3.06	No	No	0	5	8
214	R:R:M135	R:R:V58	3.04	Yes	No	0	7	6
215	R:R:I217	R:R:T213	3.04	No	No	0	9	7
216	R:R:I277	R:R:T273	3.04	No	No	0	8	9
217	R:R:L76	R:R:V75	2.98	No	No	0	6	5
218	R:R:L326	R:R:V280	2.98	No	No	0	6	7
219	R:R:N311	R:R:S310	2.98	No	No	0	1	1
220	R:R:L71	R:R:T42	2.95	No	No	0	8	5
221	R:R:L112	R:R:T108	2.95	No	No	0	5	6
222	R:R:L153	R:R:T149	2.95	No	No	0	4	3
223	R:R:D309	R:R:S310	2.94	No	No	0	4	1
224	R:R:I142	R:R:K138	2.91	No	No	0	1	4
225	R:R:W123	R:R:Y122	2.89	No	Yes	0	4	8
226	R:R:F141	R:R:P137	2.89	No	No	0	3	1
227	R:R:G93	R:R:W90	2.81	No	Yes	0	7	8
228	R:R:A47	R:R:F341	2.77	No	Yes	0	8	7
229	R:R:A140	R:R:F62	2.77	No	Yes	0	7	8
230	R:R:L72	R:R:L76	2.77	No	No	0	7	6
231	R:R:A87	R:R:F89	2.77	No	No	0	5	4
232	R:R:A101	R:R:F156	2.77	No	Yes	0	6	5
233	R:R:A229	R:R:R233	2.77	No	No	0	4	1
234	R:R:I220	R:R:Q224	2.74	No	No	0	6	7
235	R:R:E267	R:R:I225	2.73	No	No	0	8	5
236	R:R:R55	R:R:V48	2.62	No	No	0	8	8
237	R:R:F337	R:R:V48	2.62	Yes	No	0	9	8
238	R:R:F51	R:R:T343	2.59	Yes	No	0	6	4
239	R:R:S191	R:R:Y194	2.54	No	Yes	0	5	7
240	R:R:I49	R:R:R55	2.51	No	No	0	4	8
241	R:R:F264	R:R:K265	2.48	No	No	0	5	5
242	R:R:F29	R:R:L30	2.44	No	Yes	0	3	7
243	R:R:Q222	R:R:R226	2.34	No	No	0	6	5
244	R:R:Q224	R:R:R227	2.34	No	No	0	7	5
245	R:R:R219	R:R:Y218	2.06	No	Yes	0	4	7
246	R:R:C307	R:R:G299	1.96	No	No	0	3	1
247	R:R:A195	R:R:P296	1.87	No	No	0	5	5
248	R:R:G279	R:R:V282	1.84	No	No	0	5	7
249	R:R:P128	R:R:S127	1.78	No	No	0	8	6
250	R:R:P328	R:R:V44	1.77	No	Yes	0	9	9
251	R:R:G40	R:R:L39	1.71	No	No	0	9	4
252	R:R:A332	R:R:V63	1.7	No	No	0	6	8
253	R:R:A147	R:R:V116	1.7	No	No	0	7	7
254	R:R:C45	R:R:I49	1.64	No	No	0	7	4
255	R:R:A27	R:R:I86	1.62	No	No	0	6	5
256	R:R:S275	R:R:V276	1.62	No	No	0	6	7
257	R:R:A139	R:R:M135	1.61	No	Yes	0	6	7
258	R:R:S191	R:R:T193	1.6	No	No	0	5	4
259	R:R:V276	R:R:V280	1.6	No	No	0	7	7
260	R:R:S342	R:R:T343	1.6	No	No	0	5	4
261	R:R:T26	R:R:V22	1.59	No	No	0	5	4
262	R:R:T312	R:R:V315	1.59	No	No	0	4	4
263	R:R:I220	R:R:S126	1.55	No	No	0	6	7
264	R:R:I142	R:R:V146	1.54	No	No	0	1	3
265	R:R:A335	R:R:D336	1.54	No	No	0	5	7
266	R:R:K167	R:R:S162	1.53	No	No	0	2	5
267	R:R:K165	R:R:S188	1.53	No	No	0	3	5
268	R:R:K339	R:R:S342	1.53	No	No	0	5	5
269	R:R:F319	R:R:G320	1.51	No	No	0	7	7
270	R:R:K138	R:R:T136	1.5	No	No	0	4	8
271	R:R:K269	R:R:T273	1.5	No	No	0	8	9
272	R:R:L72	R:R:V68	1.49	No	No	0	7	6
273	R:R:L153	R:R:V152	1.49	No	No	0	4	4
274	R:R:I104	R:R:I154	1.47	No	No	0	6	5
275	R:R:I154	R:R:I201	1.47	No	No	0	5	4
276	R:R:D314	R:R:S310	1.47	No	No	0	4	1
277	R:R:P296	R:R:R192	1.44	No	No	0	5	4
278	R:R:I86	R:R:L30	1.43	No	Yes	0	5	7
279	R:R:I290	R:R:L286	1.43	No	No	0	7	6
280	R:R:I290	R:R:L291	1.43	No	Yes	0	7	5
281	R:R:C298	R:R:F297	1.4	No	No	0	4	6
282	R:R:L345	R:R:L43	1.38	No	No	0	7	7
283	R:R:D187	R:R:K81	1.38	No	Yes	0	5	6
284	R:R:A230	R:R:R233	1.38	No	No	0	4	1
285	R:R:A335	R:R:R338	1.38	No	No	0	5	8
286	R:R:D184	R:R:N185	1.35	No	No	0	3	4
287	R:R:F20	R:R:V22	1.31	No	No	0	1	4
288	R:R:K134	R:R:R133	1.24	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L30	3.8575	4	0	7
2	R:R:T37	5.065	4	0	7
3	R:R:N41	5.37	4	0	9
4	R:R:V44	3.4475	4	0	9
5	R:R:F51	4.972	5	0	6
6	R:R:F62	5.195	6	0	8
7	R:R:L66	5.34	4	1	9
8	R:R:D70	7.582	5	1	9
9	R:R:V77	4.3475	4	1	8
10	R:R:M78	5.4975	4	1	7
11	R:R:W80	6.4275	4	1	5
12	R:R:K81	5.13167	6	1	6
13	R:R:W90	7.43125	8	1	8
14	R:R:F92	8.748	5	1	6
15	R:R:F95	4.95	5	1	5
16	R:R:W99	5.27714	7	1	5
17	R:R:F102	6.1775	4	1	5
18	R:R:D103	8.2725	4	1	7
19	R:R:S107	4.5425	4	1	7
20	R:R:L114	5.8725	4	1	9
21	R:R:D120	7.7575	4	2	9
22	R:R:Y122	8.665	4	0	8
23	R:R:Y131	7.92	4	2	7
24	R:R:M135	4.5975	4	2	7
25	R:R:F156	3.7375	4	1	5
26	R:R:Y194	6.2025	4	0	7
27	R:R:F203	9.38833	6	1	8
28	R:R:Y214	6.302	5	0	9
29	R:R:Y218	7.3475	4	0	7
30	R:R:F281	5.69333	6	1	9
31	R:R:W285	8.4225	8	1	8
32	R:R:F288	8.436	5	1	7
33	R:R:F289	10.404	5	1	7
34	R:R:L291	6.282	5	0	5
35	R:R:W318	5.732	5	1	5
36	R:R:W321	6.02625	8	1	7
37	R:R:Y331	5.536	5	1	9
38	R:R:F337	5.0325	4	0	9
39	R:R:F341	4.5225	4	0	7
40	L:L:?1	9.16273	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M78	R:R:T37	31.6644	4.52	Yes	Yes	0	7	7
2	R:R:N41	R:R:T37	29.7922	4.39	Yes	Yes	0	9	7
3	R:R:N41	R:R:P328	45.7371	4.89	Yes	No	0	9	9
4	R:R:P328	R:R:V44	44.5011	1.77	No	Yes	0	9	9
5	R:R:F341	R:R:V44	11.4484	5.24	Yes	Yes	0	7	9
6	R:R:D70	R:R:N41	29.1792	8.08	Yes	Yes	0	9	9
7	R:R:A332	R:R:V44	31.7771	3.39	No	Yes	0	6	9
8	R:R:A332	R:R:F337	29.1527	4.16	No	Yes	0	6	9
9	R:R:F337	R:R:L54	12.85	7.31	Yes	No	0	9	9
10	R:R:H53	R:R:L54	11.4484	3.86	No	No	0	6	9
11	R:R:F51	R:R:H53	10.0401	10.18	Yes	No	0	6	6
12	R:R:D70	R:R:L66	30.0606	5.43	Yes	Yes	1	9	9
13	R:R:L66	R:R:Y331	22.2373	3.52	Yes	Yes	1	9	9
14	R:R:I117	R:R:Y331	48.7889	4.84	No	Yes	1	9	9
15	R:R:F62	R:R:I117	51.4894	3.77	Yes	No	0	8	9
16	R:R:D120	R:R:F62	24.7689	10.75	Yes	Yes	0	9	8
17	R:R:D120	R:R:M135	17.7574	4.16	Yes	Yes	2	9	7
18	R:R:M135	R:R:V58	14.3345	3.04	Yes	No	0	7	6
19	R:R:P137	R:R:V58	12.5683	3.53	No	No	0	1	6
20	R:R:S107	R:R:W321	30.4119	4.94	Yes	Yes	1	7	7
21	R:R:S107	R:R:W285	54.2861	4.94	Yes	Yes	1	7	8
22	R:R:F281	R:R:W285	100	8.02	Yes	Yes	1	9	8
23	R:R:F281	R:R:L114	65.3468	3.65	Yes	Yes	1	9	9
24	R:R:L114	R:R:Y331	48.0467	4.69	Yes	Yes	1	9	9
25	R:R:F62	R:R:I144	19.5699	3.77	Yes	No	0	8	8
26	R:R:I144	R:R:S65	17.8237	4.64	No	No	0	8	9
27	R:R:N113	R:R:S65	16.0708	8.94	No	No	0	8	9
28	R:R:A109	R:R:W148	10.7525	7.78	No	No	3	7	9
29	R:R:N113	R:R:W148	14.3113	5.65	No	No	0	8	9
30	R:R:V73	R:R:V77	10.1163	3.21	No	Yes	0	8	8
31	R:R:S324	R:R:V73	13.0853	4.85	No	No	0	9	8
32	R:R:F102	R:R:F95	42.1816	3.22	Yes	Yes	1	5	5
33	R:R:F95	R:R:W80	28.1123	8.02	Yes	Yes	1	5	5
34	R:R:W80	R:R:W99	37.7415	5.62	Yes	Yes	1	5	5
35	R:R:F95	R:R:W90	28.5099	4.01	Yes	Yes	1	5	8
36	R:R:W90	R:R:W99	52.3941	3.75	Yes	Yes	1	8	5
37	R:R:W321	R:R:W99	24.918	4.69	Yes	Yes	1	7	5
38	R:R:F102	R:R:L76	20.5275	12.18	Yes	No	0	5	6
39	L:L:?1	R:R:K81	23.0856	5.45	Yes	Yes	1	0	6
40	R:R:D314	R:R:E85	11.899	11.69	No	No	0	4	4
41	R:R:F102	R:R:F156	18.6421	4.29	Yes	Yes	1	5	5
42	R:R:A101	R:R:F156	12.6412	2.77	No	Yes	0	6	5
43	R:R:A101	R:R:V159	10.5504	5.09	No	No	0	6	5
44	L:L:?1	R:R:I104	23.7152	14.72	Yes	No	0	0	6
45	R:R:I104	R:R:Y194	13.3437	3.63	No	Yes	0	6	7
46	L:L:?1	R:R:S198	15.8388	7.74	Yes	No	0	0	7
47	R:R:S198	R:R:Y194	13.2973	8.9	No	Yes	0	7	7
48	R:R:F281	R:R:M210	84.3898	6.22	Yes	No	0	9	8
49	R:R:M210	R:R:S118	56.9104	7.67	No	No	0	8	8
50	R:R:S118	R:R:T213	39.057	3.2	No	No	0	8	7
51	R:R:S118	R:R:Y214	28.9638	10.17	No	Yes	0	8	9
52	R:R:M210	R:R:M278	26.1076	4.33	No	No	0	8	8
53	R:R:M278	R:R:Y214	22.9862	4.79	No	Yes	0	8	9
54	R:R:T213	R:R:Y122	32.2774	7.49	No	Yes	0	7	8
55	R:R:S126	R:R:Y122	20.8456	13.99	No	Yes	0	7	8
56	R:R:S126	R:R:S127	11.7267	3.26	No	No	0	7	6
57	R:R:P158	R:R:Y194	10.6664	9.74	No	Yes	0	6	7
58	R:R:A195	R:R:N292	10.3251	4.69	No	No	0	5	6
59	L:L:?1	R:R:N292	12.5949	5.31	Yes	No	0	0	6
60	L:L:?1	R:R:F289	54.1337	5.49	Yes	Yes	1	0	7
61	R:R:F203	R:R:F289	27.8571	22.51	Yes	Yes	1	8	7
62	R:R:L274	R:R:Y214	41.2041	4.69	No	Yes	0	8	9
63	R:R:I330	R:R:Y331	13.2045	8.46	No	Yes	0	8	9
64	R:R:L274	R:R:Y218	38.4738	3.52	No	Yes	0	8	7
65	R:R:Q222	R:R:Y218	27.4827	20.29	No	Yes	0	6	7
66	R:R:E267	R:R:I225	16.6772	2.73	No	No	0	8	5
67	R:R:E267	R:R:Q222	21.9457	8.92	No	No	0	8	6
68	L:L:?1	R:R:F288	29.8883	14.91	Yes	Yes	1	0	7
69	R:R:L72	R:R:L76	10.2754	2.77	No	No	0	7	6
70	R:R:S191	R:R:Y194	10.6664	2.54	No	Yes	0	5	7
71	R:R:M78	R:R:W321	24.9544	5.82	Yes	Yes	1	7	7
72	R:R:D70	R:R:S324	13.1946	11.78	Yes	No	0	9	9
73	L:L:?1	R:R:W99	67.4376	7.34	Yes	Yes	1	0	5
74	L:L:?1	R:R:S107	29.9182	3.87	Yes	Yes	1	0	7
75	R:R:R121	R:R:Y214	11.4682	8.23	No	Yes	0	9	9
76	R:R:F289	R:R:W285	29.3018	8.02	Yes	Yes	1	7	8
77	R:R:F203	R:R:F281	33.7354	8.57	Yes	Yes	1	8	9
78	R:R:F288	R:R:W285	28.659	7.02	Yes	Yes	1	7	8
79	R:R:E85	R:R:K81	11.2495	5.4	No	Yes	1	4	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V77	R:R:W99	4.9	1	Yes	Yes	8	5	2	1
R:R:D103	R:R:V77	4.38	1	Yes	Yes	7	8	1	2
R:R:V77	R:R:W321	4.9	1	Yes	Yes	8	7	2	2
R:R:W80	R:R:W99	5.62	1	Yes	Yes	5	5	2	1
R:R:E85	R:R:K81	5.4	1	No	Yes	4	6	2	1
R:R:K81	R:R:W99	6.96	1	Yes	Yes	6	5	1	1
R:R:K81	R:R:W318	6.96	1	Yes	Yes	6	5	1	2
R:R:K81	R:R:W321	4.64	1	Yes	Yes	6	7	1	2
L:L:?1	R:R:K81	5.45	1	Yes	Yes	0	6	0	1
R:R:E85	R:R:W318	4.36	1	No	Yes	4	5	2	2
R:R:W90	R:R:W99	3.75	1	Yes	Yes	8	5	2	1
R:R:V100	R:R:W99	3.68	1	No	Yes	5	5	1	1
R:R:W321	R:R:W99	4.69	1	Yes	Yes	7	5	2	1
L:L:?1	R:R:W99	7.34	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V100	7.68	1	Yes	No	0	5	0	1
R:R:D103	R:R:S107	4.42	1	Yes	Yes	7	7	1	1
R:R:D103	R:R:W321	11.17	1	Yes	Yes	7	7	1	2
L:L:?1	R:R:D103	13.12	1	Yes	Yes	0	7	0	1
R:R:I104	R:R:Y194	3.63	0	No	Yes	6	7	1	2
L:L:?1	R:R:I104	14.72	1	Yes	No	0	6	0	1
R:R:S107	R:R:W285	4.94	1	Yes	Yes	7	8	1	2
R:R:S107	R:R:W321	4.94	1	Yes	Yes	7	7	1	2
L:L:?1	R:R:S107	3.87	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L190	15.16	1	Yes	No	0	4	0	1
R:R:S198	R:R:Y194	8.9	0	No	Yes	7	7	1	2
R:R:A195	R:R:N292	4.69	0	No	No	5	6	2	1
L:L:?1	R:R:S198	7.74	1	Yes	No	0	7	0	1
R:R:F289	R:R:S199	5.28	1	Yes	No	7	7	1	2
R:R:N292	R:R:S199	4.47	0	No	No	6	7	1	2
R:R:F203	R:R:W285	5.01	1	Yes	Yes	8	8	2	2
R:R:F203	R:R:F289	22.51	1	Yes	Yes	8	7	2	1
R:R:F288	R:R:W285	7.02	1	Yes	Yes	7	8	1	2
R:R:F289	R:R:W285	8.02	1	Yes	Yes	7	8	1	2
R:R:F288	R:R:F289	10.72	1	Yes	Yes	7	7	1	1
R:R:F288	R:R:F313	4.29	1	Yes	No	7	4	1	2
R:R:F288	R:R:V317	5.24	1	Yes	No	7	6	1	2
L:L:?1	R:R:F288	14.91	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F289	5.49	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N292	5.31	1	Yes	No	0	6	0	1
R:R:V317	R:R:W321	7.36	0	No	Yes	6	7	2	2
R:R:W318	R:R:W321	4.69	1	Yes	Yes	5	7	2	2
R:R:I104	R:R:I154	1.47	0	No	No	6	5	1	2
R:R:D187	R:R:K81	1.38	0	No	Yes	5	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7X2D_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.2
Number of Linked Nodes	251
Number of Links	288
Number of Hubs	40
Number of Links mediated by Hubs	150
Number of Communities	3
Number of Nodes involved in Communities	45
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	77737
Length Of Smallest Path	3
Average Path Length	12.3514
Length of Longest Path	25
Minimum Path Strength	1.43
Average Path Strength	5.9863
Maximum Path Strength	17.205
Minimum Path Correlation	0.7
Average Path Correlation	0.92977
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	51.753
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	55.2003
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	86W
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	86W
Name	Tavapadon
Synonyms	Tavapadon
Identifier
Formula	C19 H16 F3 N3 O3
Molecular Weight	391.344
SMILES
PubChem	86764100
Formal Charge	0
Total Atoms	44
Total Chiral Atoms	0
Total Bonds	46
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21728
Sequence	>7X2D_nogp_Chain_R F S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F R H L R S K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G F W P F G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S P F R Y E R K M T P K A A F I L I S V A W T L S V L I S F I P V Q L S W H K A K D N C D S S L S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C G F C I D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F R K A F S T L L G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4NTJ	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	AZD1283	-	-	2.62	2014-03-26	doi.org/10.1038/nature13083
	7AD3	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	Gi1/STE4/γ2	3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7AD3 (No Gprot)	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-		3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7JV5	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JV5 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7CKW	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKW (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-		3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-	Gs/β1/γ2	3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-		3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-	Gs/β1/γ2	3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-		3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKZ	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7LJC	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	Mevidalen	Gs/β1/γ2	3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJC (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	Mevidalen		3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ1	3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7CMV	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-	Gi1/β1/γ2	2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7CMV (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-		2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7JOZ	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 75202022	-	Gs/β1/γ2	3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7JOZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 75202022	-		3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7QA8	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	Antagonist Peptide	-	-	2.7	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QB9	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	-	-	-	3.1	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBC	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.53	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBI	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.46	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7F0T	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-	Gs/β1/γ2	3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F0T (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-		3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1O	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg	Gs/β1/γ2	3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1O (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg		3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7X2D	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-	Gs/β1/γ2	3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2D (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-		3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2F	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2F (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2C	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam	Gs/β1/γ2	3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7X2C (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam		3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7W41	A	Peptide	Bombesin	BB₂	Homo sapiens	PD176252	-	-	2.95	2023-02-22	doi.org/10.1073/pnas.2216230120
	8IRR	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-	Gs/β1/γ2	3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8IRR (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-		3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8JD1	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	-	-	3.7	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8JXR	A	Amine	Dopamine	D₁	Homo sapiens	LSD	-	-	3.57	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8JXS	A	Amine	Dopamine	D₁	Homo sapiens	PF-6142	-	-	3	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JF4	A	Peptide	Bombesin	BB₁	Homo sapiens	PD168368	-	-	3.6	2025-07-09	To be published
	9I52	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-	Gs/β1/γ2	2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I52 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-		2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 176452091	-	Gs/β1/γ2	2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 176452091	-		2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9V0U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9V0U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

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