psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L25	R:R:V22	5.96	No	No	0	4	4
2	R:R:F29	R:R:L33	7.31	No	No	0	3	7
3	R:R:A82	R:R:L30	4.73	No	Yes	0	6	7
4	R:R:L30	R:R:W318	6.83	Yes	Yes	0	7	5
5	R:R:I34	R:R:M78	5.83	No	Yes	0	6	7
6	R:R:S325	R:R:S36	4.89	No	No	0	6	4
7	R:R:N41	R:R:T37	4.39	Yes	Yes	0	9	7
8	R:R:A74	R:R:T37	3.36	No	Yes	0	7	7
9	R:R:M78	R:R:T37	4.52	Yes	Yes	0	7	7
10	R:R:S325	R:R:T37	7.99	No	Yes	0	6	7
11	R:R:L39	R:R:L43	5.54	No	No	0	4	7
12	R:R:D70	R:R:N41	8.08	Yes	Yes	0	9	9
13	R:R:L71	R:R:N41	4.12	No	Yes	0	8	9
14	R:R:N41	R:R:P328	4.89	Yes	No	0	9	9
15	R:R:F341	R:R:L43	3.65	Yes	No	0	7	7
16	R:R:A67	R:R:V44	3.39	No	Yes	0	9	9
17	R:R:A332	R:R:V44	3.39	No	Yes	0	6	9
18	R:R:F341	R:R:V44	5.24	Yes	Yes	0	7	9
19	R:R:I64	R:R:V48	7.68	No	No	0	6	8
20	R:R:F51	R:R:R50	4.28	Yes	No	0	6	6
21	R:R:F51	R:R:H53	10.18	Yes	No	0	6	6
22	R:R:A340	R:R:F51	4.16	No	Yes	0	7	6
23	R:R:F51	R:R:L344	3.65	Yes	No	0	6	6
24	R:R:H53	R:R:L54	3.86	No	No	0	6	9
25	R:R:F337	R:R:L54	7.31	Yes	No	0	9	9
26	R:R:K57	R:R:N60	4.2	No	No	0	5	9
27	R:R:D336	R:R:K57	4.15	No	No	0	7	5
28	R:R:P137	R:R:V58	3.53	No	No	0	1	6
29	R:R:D120	R:R:T59	5.78	Yes	No	2	9	8
30	R:R:T59	R:R:Y131	3.75	No	Yes	2	8	7
31	R:R:F337	R:R:N60	6.04	Yes	No	0	9	9
32	R:R:F141	R:R:F61	5.36	No	No	0	3	4
33	R:R:F62	R:R:V116	5.24	Yes	No	0	8	7
34	R:R:F62	R:R:I117	3.77	Yes	No	0	8	9
35	R:R:D120	R:R:F62	10.75	Yes	Yes	0	9	8
36	R:R:F62	R:R:L143	4.87	Yes	No	0	8	7
37	R:R:F62	R:R:I144	3.77	Yes	No	0	8	8
38	R:R:N113	R:R:S65	8.94	No	No	0	8	9
39	R:R:I144	R:R:S65	4.64	No	No	0	8	9
40	R:R:D70	R:R:L66	5.43	Yes	Yes	1	9	9
41	R:R:L114	R:R:L66	5.54	Yes	Yes	1	9	9
42	R:R:L66	R:R:N327	6.87	Yes	No	1	9	9
43	R:R:L66	R:R:Y331	3.52	Yes	Yes	1	9	9
44	R:R:A109	R:R:S69	3.42	No	No	3	7	8
45	R:R:S69	R:R:W148	4.94	No	No	3	8	9
46	R:R:D70	R:R:S110	5.89	Yes	No	0	9	9
47	R:R:D70	R:R:S324	11.78	Yes	No	0	9	9
48	R:R:D70	R:R:N327	6.73	Yes	No	1	9	9
49	R:R:V73	R:R:V77	3.21	No	Yes	0	8	8
50	R:R:C106	R:R:V73	5.12	No	No	0	7	8
51	R:R:S324	R:R:V73	4.85	No	No	0	9	8
52	R:R:F102	R:R:L76	12.18	Yes	No	0	5	6
53	R:R:V77	R:R:W99	4.9	Yes	Yes	1	8	5
54	R:R:D103	R:R:V77	4.38	Yes	Yes	1	7	8
55	R:R:V77	R:R:W321	4.9	Yes	Yes	1	8	7
56	R:R:M78	R:R:W318	5.82	Yes	Yes	1	7	5
57	R:R:M78	R:R:W321	5.82	Yes	Yes	1	7	7
58	R:R:P79	R:R:W80	4.05	No	Yes	0	8	5
59	R:R:F92	R:R:W80	8.02	Yes	Yes	1	6	5
60	R:R:F95	R:R:W80	8.02	Yes	Yes	1	5	5
61	R:R:W80	R:R:W99	5.62	Yes	Yes	1	5	5
62	R:R:E85	R:R:K81	5.4	No	Yes	1	4	6
63	R:R:K81	R:R:W99	6.96	Yes	Yes	1	6	5
64	R:R:K81	R:R:W318	6.96	Yes	Yes	1	6	5
65	R:R:K81	R:R:W321	4.64	Yes	Yes	1	6	7
66	L:L:?1	R:R:K81	5.45	Yes	Yes	1	0	6
67	R:R:F92	R:R:V83	5.24	Yes	No	0	6	4
68	R:R:A84	R:R:W90	3.89	No	Yes	0	5	8
69	R:R:D314	R:R:E85	11.69	No	No	0	4	4
70	R:R:E85	R:R:W318	4.36	No	Yes	1	4	5
71	R:R:F89	R:R:P91	5.78	No	No	0	4	1
72	R:R:P91	R:R:W90	4.05	No	Yes	1	1	8
73	R:R:F92	R:R:W90	20.04	Yes	Yes	1	6	8
74	R:R:F95	R:R:W90	4.01	Yes	Yes	1	5	8
75	R:R:C96	R:R:W90	6.53	No	Yes	1	9	8
76	R:R:W90	R:R:W99	3.75	Yes	Yes	1	8	5
77	R:R:C186	R:R:W90	14.37	No	Yes	1	9	8
78	R:R:F92	R:R:P91	7.22	Yes	No	1	6	1
79	R:R:F92	R:R:F95	3.22	Yes	Yes	1	6	5
80	R:R:F95	R:R:I98	6.28	Yes	No	1	5	6
81	R:R:F102	R:R:F95	3.22	Yes	Yes	1	5	5
82	R:R:C186	R:R:C96	5.46	No	No	1	9	9
83	R:R:H164	R:R:N97	6.38	No	No	0	5	6
84	R:R:F102	R:R:I98	5.02	Yes	No	1	5	6
85	R:R:I98	R:R:Q160	4.12	No	No	0	6	5
86	R:R:V100	R:R:W99	3.68	No	Yes	1	5	5
87	R:R:W321	R:R:W99	4.69	Yes	Yes	1	7	5
88	L:L:?1	R:R:W99	7.34	Yes	Yes	1	0	5
89	L:L:?1	R:R:V100	7.68	Yes	No	1	0	5
90	R:R:A101	R:R:V159	5.09	No	No	0	6	5
91	R:R:F102	R:R:F156	4.29	Yes	Yes	1	5	5
92	R:R:D103	R:R:S107	4.42	Yes	Yes	1	7	7
93	R:R:D103	R:R:W321	11.17	Yes	Yes	1	7	7
94	L:L:?1	R:R:D103	13.12	Yes	Yes	1	0	7
95	R:R:I104	R:R:Y194	3.63	No	Yes	0	6	7
96	L:L:?1	R:R:I104	14.72	Yes	No	0	0	6
97	R:R:C106	R:R:M105	3.24	No	No	0	7	5
98	R:R:M105	R:R:S155	4.6	No	No	0	5	7
99	R:R:S107	R:R:W285	4.94	Yes	Yes	1	7	8
100	R:R:S107	R:R:W321	4.94	Yes	Yes	1	7	7
101	L:L:?1	R:R:S107	3.87	Yes	Yes	1	0	7
102	R:R:S151	R:R:T108	3.2	No	No	0	8	6
103	R:R:S202	R:R:T108	9.59	No	No	0	6	6
104	R:R:A109	R:R:W148	7.78	No	No	3	7	9
105	R:R:A109	R:R:S151	3.42	No	No	0	7	8
106	R:R:I111	R:R:P206	3.39	No	No	0	8	9
107	R:R:F281	R:R:I111	3.77	Yes	No	1	9	8
108	R:R:I111	R:R:W285	12.92	No	Yes	1	8	8
109	R:R:L112	R:R:L150	4.15	No	No	0	5	4
110	R:R:N113	R:R:W148	5.65	No	No	0	8	9
111	R:R:F281	R:R:L114	3.65	Yes	Yes	1	9	9
112	R:R:L114	R:R:N327	9.61	Yes	No	1	9	9
113	R:R:L114	R:R:Y331	4.69	Yes	Yes	1	9	9
114	R:R:C115	R:R:P206	3.77	No	No	0	7	9
115	R:R:C115	R:R:I209	4.91	No	No	0	7	6
116	R:R:I117	R:R:R121	5.01	No	No	1	9	9
117	R:R:I117	R:R:Y331	4.84	No	Yes	1	9	9
118	R:R:M210	R:R:S118	7.67	No	No	0	8	8
119	R:R:S118	R:R:T213	3.2	No	No	0	8	7
120	R:R:S118	R:R:Y214	10.17	No	Yes	0	8	9
121	R:R:V119	R:R:W123	7.36	No	No	0	6	4
122	R:R:D120	R:R:Y131	10.34	Yes	Yes	2	9	7
123	R:R:D120	R:R:M135	4.16	Yes	Yes	2	9	7
124	R:R:R121	R:R:Y214	8.23	No	Yes	0	9	9
125	R:R:R121	R:R:Y331	6.17	No	Yes	1	9	9
126	R:R:S126	R:R:Y122	13.99	No	Yes	0	7	8
127	R:R:T213	R:R:Y122	7.49	No	Yes	0	7	8
128	R:R:R216	R:R:Y122	10.29	No	Yes	0	5	8
129	R:R:A124	R:R:Y131	8.01	No	Yes	0	8	7
130	R:R:I125	R:R:I217	4.42	No	No	0	8	9
131	R:R:S126	R:R:S127	3.26	No	No	0	7	6
132	R:R:R130	R:R:S127	9.22	No	No	0	5	6
133	R:R:K134	R:R:R130	4.95	No	No	0	5	5
134	R:R:M135	R:R:Y131	9.58	Yes	Yes	2	7	7
135	R:R:P137	R:R:T136	3.5	No	No	0	1	8
136	R:R:S155	R:R:V152	3.23	No	No	1	7	4
137	R:R:F156	R:R:V152	3.93	Yes	No	1	5	4
138	R:R:F156	R:R:S155	3.96	Yes	No	1	5	7
139	R:R:I157	R:R:P158	3.39	No	No	0	6	6
140	R:R:P158	R:R:Y194	9.74	No	Yes	0	6	7
141	R:R:H164	R:R:V159	12.45	No	No	0	5	5
142	R:R:L161	R:R:W163	5.69	No	No	0	4	6
143	R:R:H164	R:R:K165	10.48	No	No	0	5	3
144	R:R:D187	R:R:N185	8.08	No	No	0	5	4
145	L:L:?1	R:R:L190	15.16	Yes	No	0	0	4
146	R:R:S198	R:R:Y194	8.9	No	Yes	0	7	7
147	R:R:A195	R:R:N292	4.69	No	No	0	5	6
148	R:R:C293	R:R:I196	3.27	No	No	0	6	6
149	L:L:?1	R:R:S198	7.74	Yes	No	0	0	7
150	R:R:F289	R:R:S199	5.28	Yes	No	0	7	7
151	R:R:N292	R:R:S199	4.47	No	No	0	6	7
152	R:R:C293	R:R:S199	3.44	No	No	0	6	7
153	R:R:F203	R:R:Y204	6.19	Yes	No	0	8	5
154	R:R:F203	R:R:V207	9.18	Yes	No	0	8	7
155	R:R:F203	R:R:F281	8.57	Yes	Yes	1	8	9
156	R:R:F203	R:R:W285	5.01	Yes	Yes	1	8	8
157	R:R:F203	R:R:L286	4.87	Yes	No	0	8	6
158	R:R:F203	R:R:F289	22.51	Yes	Yes	1	8	7
159	R:R:C293	R:R:Y204	5.38	No	No	0	6	5
160	R:R:I205	R:R:P206	3.39	No	No	0	5	9
161	R:R:M210	R:R:M278	4.33	No	No	0	8	8
162	R:R:F281	R:R:M210	6.22	Yes	No	0	9	8
163	R:R:I211	R:R:M278	4.37	No	No	0	6	8
164	R:R:R216	R:R:V212	5.23	No	No	0	5	4
165	R:R:L274	R:R:Y214	4.69	No	Yes	0	8	9
166	R:R:I277	R:R:Y214	3.63	No	Yes	0	8	9
167	R:R:M278	R:R:Y214	4.79	No	Yes	0	8	9
168	R:R:R219	R:R:T215	3.88	No	No	0	4	3
169	R:R:Q222	R:R:Y218	20.29	No	Yes	0	6	7
170	R:R:L271	R:R:Y218	3.52	No	Yes	0	7	7
171	R:R:L274	R:R:Y218	3.52	No	Yes	0	8	7
172	R:R:A221	R:R:V270	3.39	No	No	0	9	8
173	R:R:E267	R:R:Q222	8.92	No	No	0	8	6
174	R:R:I225	R:R:R266	3.76	No	No	0	5	6
175	R:R:I228	R:R:R266	5.01	No	No	0	7	6
176	R:R:E232	R:R:R266	5.82	No	No	0	3	6
177	R:R:E267	R:R:T268	5.64	No	No	0	8	5
178	R:R:I277	R:R:I330	4.42	No	No	0	8	8
179	R:R:I330	R:R:V280	4.61	No	No	0	8	7
180	R:R:F281	R:R:V282	3.93	Yes	No	0	9	7
181	R:R:F281	R:R:W285	8.02	Yes	Yes	1	9	8
182	R:R:C284	R:R:N323	6.3	No	No	0	9	9
183	R:R:F288	R:R:W285	7.02	Yes	Yes	1	7	8
184	R:R:F289	R:R:W285	8.02	Yes	Yes	1	7	8
185	R:R:G320	R:R:W285	5.63	No	Yes	1	7	8
186	R:R:N323	R:R:W285	15.82	No	Yes	1	9	8
187	R:R:L286	R:R:P287	3.28	No	No	0	6	9
188	R:R:F316	R:R:P287	4.33	No	No	0	5	9
189	R:R:F288	R:R:F289	10.72	Yes	Yes	1	7	7
190	R:R:F288	R:R:F313	4.29	Yes	No	0	7	4
191	R:R:F288	R:R:V317	5.24	Yes	No	0	7	6
192	L:L:?1	R:R:F288	14.91	Yes	Yes	1	0	7
193	L:L:?1	R:R:F289	5.49	Yes	Yes	1	0	7
194	R:R:L291	R:R:L295	4.15	Yes	No	0	5	3
195	R:R:I308	R:R:L291	9.99	No	Yes	0	4	5
196	R:R:F313	R:R:L291	8.53	No	Yes	0	4	5
197	R:R:F316	R:R:L291	7.31	No	Yes	0	5	5
198	L:L:?1	R:R:N292	5.31	Yes	No	0	0	6
199	R:R:I308	R:R:T312	4.56	No	No	0	4	4
200	R:R:F316	R:R:T312	5.19	No	No	0	5	4
201	R:R:V317	R:R:W321	7.36	No	Yes	0	6	7
202	R:R:W318	R:R:W321	4.69	Yes	Yes	1	5	7
203	R:R:G320	R:R:N323	5.09	No	No	1	7	9
204	R:R:F333	R:R:I329	6.28	No	No	0	8	7
205	R:R:I330	R:R:Y331	8.46	No	Yes	0	8	9
206	R:R:A332	R:R:F337	4.16	No	Yes	0	6	9
207	R:R:F333	R:R:F341	6.43	No	Yes	0	8	7
208	R:R:A322	R:R:L33	3.15	No	No	0	4	7
209	R:R:A74	R:R:L38	3.15	No	No	0	7	7
210	R:R:I201	R:R:S197	3.1	No	No	0	4	4
211	R:R:I205	R:R:V200	3.07	No	No	0	5	4
212	R:R:I225	R:R:V270	3.07	No	No	0	5	8
213	R:R:K57	R:R:S56	3.06	No	No	0	5	8
214	R:R:M135	R:R:V58	3.04	Yes	No	0	7	6
215	R:R:I217	R:R:T213	3.04	No	No	0	9	7
216	R:R:I277	R:R:T273	3.04	No	No	0	8	9
217	R:R:L76	R:R:V75	2.98	No	No	0	6	5
218	R:R:L326	R:R:V280	2.98	No	No	0	6	7
219	R:R:N311	R:R:S310	2.98	No	No	0	1	1
220	R:R:L71	R:R:T42	2.95	No	No	0	8	5
221	R:R:L112	R:R:T108	2.95	No	No	0	5	6
222	R:R:L153	R:R:T149	2.95	No	No	0	4	3
223	R:R:D309	R:R:S310	2.94	No	No	0	4	1
224	R:R:I142	R:R:K138	2.91	No	No	0	1	4
225	R:R:W123	R:R:Y122	2.89	No	Yes	0	4	8
226	R:R:F141	R:R:P137	2.89	No	No	0	3	1
227	R:R:G93	R:R:W90	2.81	No	Yes	0	7	8
228	R:R:A47	R:R:F341	2.77	No	Yes	0	8	7
229	R:R:A140	R:R:F62	2.77	No	Yes	0	7	8
230	R:R:L72	R:R:L76	2.77	No	No	0	7	6
231	R:R:A87	R:R:F89	2.77	No	No	0	5	4
232	R:R:A101	R:R:F156	2.77	No	Yes	0	6	5
233	R:R:A229	R:R:R233	2.77	No	No	0	4	1
234	R:R:I220	R:R:Q224	2.74	No	No	0	6	7
235	R:R:E267	R:R:I225	2.73	No	No	0	8	5
236	R:R:R55	R:R:V48	2.62	No	No	0	8	8
237	R:R:F337	R:R:V48	2.62	Yes	No	0	9	8
238	R:R:F51	R:R:T343	2.59	Yes	No	0	6	4
239	R:R:S191	R:R:Y194	2.54	No	Yes	0	5	7
240	R:R:I49	R:R:R55	2.51	No	No	0	4	8
241	R:R:F264	R:R:K265	2.48	No	No	0	5	5
242	R:R:F29	R:R:L30	2.44	No	Yes	0	3	7
243	R:R:Q222	R:R:R226	2.34	No	No	0	6	5
244	R:R:Q224	R:R:R227	2.34	No	No	0	7	5
245	R:R:R219	R:R:Y218	2.06	No	Yes	0	4	7
246	R:R:C307	R:R:G299	1.96	No	No	0	3	1
247	R:R:A195	R:R:P296	1.87	No	No	0	5	5
248	R:R:G279	R:R:V282	1.84	No	No	0	5	7
249	R:R:P128	R:R:S127	1.78	No	No	0	8	6
250	R:R:P328	R:R:V44	1.77	No	Yes	0	9	9
251	R:R:G40	R:R:L39	1.71	No	No	0	9	4
252	R:R:A332	R:R:V63	1.7	No	No	0	6	8
253	R:R:A147	R:R:V116	1.7	No	No	0	7	7
254	R:R:C45	R:R:I49	1.64	No	No	0	7	4
255	R:R:A27	R:R:I86	1.62	No	No	0	6	5
256	R:R:S275	R:R:V276	1.62	No	No	0	6	7
257	R:R:A139	R:R:M135	1.61	No	Yes	0	6	7
258	R:R:S191	R:R:T193	1.6	No	No	0	5	4
259	R:R:V276	R:R:V280	1.6	No	No	0	7	7
260	R:R:S342	R:R:T343	1.6	No	No	0	5	4
261	R:R:T26	R:R:V22	1.59	No	No	0	5	4
262	R:R:T312	R:R:V315	1.59	No	No	0	4	4
263	R:R:I220	R:R:S126	1.55	No	No	0	6	7
264	R:R:I142	R:R:V146	1.54	No	No	0	1	3
265	R:R:A335	R:R:D336	1.54	No	No	0	5	7
266	R:R:K167	R:R:S162	1.53	No	No	0	2	5
267	R:R:K165	R:R:S188	1.53	No	No	0	3	5
268	R:R:K339	R:R:S342	1.53	No	No	0	5	5
269	R:R:F319	R:R:G320	1.51	No	No	0	7	7
270	R:R:K138	R:R:T136	1.5	No	No	0	4	8
271	R:R:K269	R:R:T273	1.5	No	No	0	8	9
272	R:R:L72	R:R:V68	1.49	No	No	0	7	6
273	R:R:L153	R:R:V152	1.49	No	No	0	4	4
274	R:R:I104	R:R:I154	1.47	No	No	0	6	5
275	R:R:I154	R:R:I201	1.47	No	No	0	5	4
276	R:R:D314	R:R:S310	1.47	No	No	0	4	1
277	R:R:P296	R:R:R192	1.44	No	No	0	5	4
278	R:R:I86	R:R:L30	1.43	No	Yes	0	5	7
279	R:R:I290	R:R:L286	1.43	No	No	0	7	6
280	R:R:I290	R:R:L291	1.43	No	Yes	0	7	5
281	R:R:C298	R:R:F297	1.4	No	No	0	4	6
282	R:R:L345	R:R:L43	1.38	No	No	0	7	7
283	R:R:D187	R:R:K81	1.38	No	Yes	0	5	6
284	R:R:A230	R:R:R233	1.38	No	No	0	4	1
285	R:R:A335	R:R:R338	1.38	No	No	0	5	8
286	R:R:D184	R:R:N185	1.35	No	No	0	3	4
287	R:R:F20	R:R:V22	1.31	No	No	0	1	4
288	R:R:K134	R:R:R133	1.24	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L30	3.8575	4	0	7
2	R:R:T37	5.065	4	0	7
3	R:R:N41	5.37	4	0	9
4	R:R:V44	3.4475	4	0	9
5	R:R:F51	4.972	5	0	6
6	R:R:F62	5.195	6	0	8
7	R:R:L66	5.34	4	1	9
8	R:R:D70	7.582	5	1	9
9	R:R:V77	4.3475	4	1	8
10	R:R:M78	5.4975	4	1	7
11	R:R:W80	6.4275	4	1	5
12	R:R:K81	5.13167	6	1	6
13	R:R:W90	7.43125	8	1	8
14	R:R:F92	8.748	5	1	6
15	R:R:F95	4.95	5	1	5
16	R:R:W99	5.27714	7	1	5
17	R:R:F102	6.1775	4	1	5
18	R:R:D103	8.2725	4	1	7
19	R:R:S107	4.5425	4	1	7
20	R:R:L114	5.8725	4	1	9
21	R:R:D120	7.7575	4	2	9
22	R:R:Y122	8.665	4	0	8
23	R:R:Y131	7.92	4	2	7
24	R:R:M135	4.5975	4	2	7
25	R:R:F156	3.7375	4	1	5
26	R:R:Y194	6.2025	4	0	7
27	R:R:F203	9.38833	6	1	8
28	R:R:Y214	6.302	5	0	9
29	R:R:Y218	7.3475	4	0	7
30	R:R:F281	5.69333	6	1	9
31	R:R:W285	8.4225	8	1	8
32	R:R:F288	8.436	5	1	7
33	R:R:F289	10.404	5	1	7
34	R:R:L291	6.282	5	0	5
35	R:R:W318	5.732	5	1	5
36	R:R:W321	6.02625	8	1	7
37	R:R:Y331	5.536	5	1	9
38	R:R:F337	5.0325	4	0	9
39	R:R:F341	4.5225	4	0	7
40	L:L:?1	9.16273	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M78	R:R:T37	31.6644	4.52	Yes	Yes	0	7	7
2	R:R:N41	R:R:T37	29.7922	4.39	Yes	Yes	0	9	7
3	R:R:N41	R:R:P328	45.7371	4.89	Yes	No	0	9	9
4	R:R:P328	R:R:V44	44.5011	1.77	No	Yes	0	9	9
5	R:R:F341	R:R:V44	11.4484	5.24	Yes	Yes	0	7	9
6	R:R:D70	R:R:N41	29.1792	8.08	Yes	Yes	0	9	9
7	R:R:A332	R:R:V44	31.7771	3.39	No	Yes	0	6	9
8	R:R:A332	R:R:F337	29.1527	4.16	No	Yes	0	6	9
9	R:R:F337	R:R:L54	12.85	7.31	Yes	No	0	9	9
10	R:R:H53	R:R:L54	11.4484	3.86	No	No	0	6	9
11	R:R:F51	R:R:H53	10.0401	10.18	Yes	No	0	6	6
12	R:R:D70	R:R:L66	30.0606	5.43	Yes	Yes	1	9	9
13	R:R:L66	R:R:Y331	22.2373	3.52	Yes	Yes	1	9	9
14	R:R:I117	R:R:Y331	48.7889	4.84	No	Yes	1	9	9
15	R:R:F62	R:R:I117	51.4894	3.77	Yes	No	0	8	9
16	R:R:D120	R:R:F62	24.7689	10.75	Yes	Yes	0	9	8
17	R:R:D120	R:R:M135	17.7574	4.16	Yes	Yes	2	9	7
18	R:R:M135	R:R:V58	14.3345	3.04	Yes	No	0	7	6
19	R:R:P137	R:R:V58	12.5683	3.53	No	No	0	1	6
20	R:R:S107	R:R:W321	30.4119	4.94	Yes	Yes	1	7	7
21	R:R:S107	R:R:W285	54.2861	4.94	Yes	Yes	1	7	8
22	R:R:F281	R:R:W285	100	8.02	Yes	Yes	1	9	8
23	R:R:F281	R:R:L114	65.3468	3.65	Yes	Yes	1	9	9
24	R:R:L114	R:R:Y331	48.0467	4.69	Yes	Yes	1	9	9
25	R:R:F62	R:R:I144	19.5699	3.77	Yes	No	0	8	8
26	R:R:I144	R:R:S65	17.8237	4.64	No	No	0	8	9
27	R:R:N113	R:R:S65	16.0708	8.94	No	No	0	8	9
28	R:R:A109	R:R:W148	10.7525	7.78	No	No	3	7	9
29	R:R:N113	R:R:W148	14.3113	5.65	No	No	0	8	9
30	R:R:V73	R:R:V77	10.1163	3.21	No	Yes	0	8	8
31	R:R:S324	R:R:V73	13.0853	4.85	No	No	0	9	8
32	R:R:F102	R:R:F95	42.1816	3.22	Yes	Yes	1	5	5
33	R:R:F95	R:R:W80	28.1123	8.02	Yes	Yes	1	5	5
34	R:R:W80	R:R:W99	37.7415	5.62	Yes	Yes	1	5	5
35	R:R:F95	R:R:W90	28.5099	4.01	Yes	Yes	1	5	8
36	R:R:W90	R:R:W99	52.3941	3.75	Yes	Yes	1	8	5
37	R:R:W321	R:R:W99	24.918	4.69	Yes	Yes	1	7	5
38	R:R:F102	R:R:L76	20.5275	12.18	Yes	No	0	5	6
39	L:L:?1	R:R:K81	23.0856	5.45	Yes	Yes	1	0	6
40	R:R:D314	R:R:E85	11.899	11.69	No	No	0	4	4
41	R:R:F102	R:R:F156	18.6421	4.29	Yes	Yes	1	5	5
42	R:R:A101	R:R:F156	12.6412	2.77	No	Yes	0	6	5
43	R:R:A101	R:R:V159	10.5504	5.09	No	No	0	6	5
44	L:L:?1	R:R:I104	23.7152	14.72	Yes	No	0	0	6
45	R:R:I104	R:R:Y194	13.3437	3.63	No	Yes	0	6	7
46	L:L:?1	R:R:S198	15.8388	7.74	Yes	No	0	0	7
47	R:R:S198	R:R:Y194	13.2973	8.9	No	Yes	0	7	7
48	R:R:F281	R:R:M210	84.3898	6.22	Yes	No	0	9	8
49	R:R:M210	R:R:S118	56.9104	7.67	No	No	0	8	8
50	R:R:S118	R:R:T213	39.057	3.2	No	No	0	8	7
51	R:R:S118	R:R:Y214	28.9638	10.17	No	Yes	0	8	9
52	R:R:M210	R:R:M278	26.1076	4.33	No	No	0	8	8
53	R:R:M278	R:R:Y214	22.9862	4.79	No	Yes	0	8	9
54	R:R:T213	R:R:Y122	32.2774	7.49	No	Yes	0	7	8
55	R:R:S126	R:R:Y122	20.8456	13.99	No	Yes	0	7	8
56	R:R:S126	R:R:S127	11.7267	3.26	No	No	0	7	6
57	R:R:P158	R:R:Y194	10.6664	9.74	No	Yes	0	6	7
58	R:R:A195	R:R:N292	10.3251	4.69	No	No	0	5	6
59	L:L:?1	R:R:N292	12.5949	5.31	Yes	No	0	0	6
60	L:L:?1	R:R:F289	54.1337	5.49	Yes	Yes	1	0	7
61	R:R:F203	R:R:F289	27.8571	22.51	Yes	Yes	1	8	7
62	R:R:L274	R:R:Y214	41.2041	4.69	No	Yes	0	8	9
63	R:R:I330	R:R:Y331	13.2045	8.46	No	Yes	0	8	9
64	R:R:L274	R:R:Y218	38.4738	3.52	No	Yes	0	8	7
65	R:R:Q222	R:R:Y218	27.4827	20.29	No	Yes	0	6	7
66	R:R:E267	R:R:I225	16.6772	2.73	No	No	0	8	5
67	R:R:E267	R:R:Q222	21.9457	8.92	No	No	0	8	6
68	L:L:?1	R:R:F288	29.8883	14.91	Yes	Yes	1	0	7
69	R:R:L72	R:R:L76	10.2754	2.77	No	No	0	7	6
70	R:R:S191	R:R:Y194	10.6664	2.54	No	Yes	0	5	7
71	R:R:M78	R:R:W321	24.9544	5.82	Yes	Yes	1	7	7
72	R:R:D70	R:R:S324	13.1946	11.78	Yes	No	0	9	9
73	L:L:?1	R:R:W99	67.4376	7.34	Yes	Yes	1	0	5
74	L:L:?1	R:R:S107	29.9182	3.87	Yes	Yes	1	0	7
75	R:R:R121	R:R:Y214	11.4682	8.23	No	Yes	0	9	9
76	R:R:F289	R:R:W285	29.3018	8.02	Yes	Yes	1	7	8
77	R:R:F203	R:R:F281	33.7354	8.57	Yes	Yes	1	8	9
78	R:R:F288	R:R:W285	28.659	7.02	Yes	Yes	1	7	8
79	R:R:E85	R:R:K81	11.2495	5.4	No	Yes	1	4	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V77	R:R:W99	4.9	1	Yes	Yes	8	5	2	1
R:R:D103	R:R:V77	4.38	1	Yes	Yes	7	8	1	2
R:R:V77	R:R:W321	4.9	1	Yes	Yes	8	7	2	2
R:R:W80	R:R:W99	5.62	1	Yes	Yes	5	5	2	1
R:R:E85	R:R:K81	5.4	1	No	Yes	4	6	2	1
R:R:K81	R:R:W99	6.96	1	Yes	Yes	6	5	1	1
R:R:K81	R:R:W318	6.96	1	Yes	Yes	6	5	1	2
R:R:K81	R:R:W321	4.64	1	Yes	Yes	6	7	1	2
L:L:?1	R:R:K81	5.45	1	Yes	Yes	0	6	0	1
R:R:E85	R:R:W318	4.36	1	No	Yes	4	5	2	2
R:R:W90	R:R:W99	3.75	1	Yes	Yes	8	5	2	1
R:R:V100	R:R:W99	3.68	1	No	Yes	5	5	1	1
R:R:W321	R:R:W99	4.69	1	Yes	Yes	7	5	2	1
L:L:?1	R:R:W99	7.34	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V100	7.68	1	Yes	No	0	5	0	1
R:R:D103	R:R:S107	4.42	1	Yes	Yes	7	7	1	1
R:R:D103	R:R:W321	11.17	1	Yes	Yes	7	7	1	2
L:L:?1	R:R:D103	13.12	1	Yes	Yes	0	7	0	1
R:R:I104	R:R:Y194	3.63	0	No	Yes	6	7	1	2
L:L:?1	R:R:I104	14.72	1	Yes	No	0	6	0	1
R:R:S107	R:R:W285	4.94	1	Yes	Yes	7	8	1	2
R:R:S107	R:R:W321	4.94	1	Yes	Yes	7	7	1	2
L:L:?1	R:R:S107	3.87	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L190	15.16	1	Yes	No	0	4	0	1
R:R:S198	R:R:Y194	8.9	0	No	Yes	7	7	1	2
R:R:A195	R:R:N292	4.69	0	No	No	5	6	2	1
L:L:?1	R:R:S198	7.74	1	Yes	No	0	7	0	1
R:R:F289	R:R:S199	5.28	1	Yes	No	7	7	1	2
R:R:N292	R:R:S199	4.47	0	No	No	6	7	1	2
R:R:F203	R:R:W285	5.01	1	Yes	Yes	8	8	2	2
R:R:F203	R:R:F289	22.51	1	Yes	Yes	8	7	2	1
R:R:F288	R:R:W285	7.02	1	Yes	Yes	7	8	1	2
R:R:F289	R:R:W285	8.02	1	Yes	Yes	7	8	1	2
R:R:F288	R:R:F289	10.72	1	Yes	Yes	7	7	1	1
R:R:F288	R:R:F313	4.29	1	Yes	No	7	4	1	2
R:R:F288	R:R:V317	5.24	1	Yes	No	7	6	1	2
L:L:?1	R:R:F288	14.91	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F289	5.49	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N292	5.31	1	Yes	No	0	6	0	1
R:R:V317	R:R:W321	7.36	0	No	Yes	6	7	2	2
R:R:W318	R:R:W321	4.69	1	Yes	Yes	5	7	2	2
R:R:I104	R:R:I154	1.47	0	No	No	6	5	1	2
R:R:D187	R:R:K81	1.38	0	No	Yes	5	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7X2D_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.2
Number of Linked Nodes	251
Number of Links	288
Number of Hubs	40
Number of Links mediated by Hubs	150
Number of Communities	3
Number of Nodes involved in Communities	45
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	77737
Length Of Smallest Path	3
Average Path Length	12.3514
Length of Longest Path	25
Minimum Path Strength	1.43
Average Path Strength	5.9863
Maximum Path Strength	17.205
Minimum Path Correlation	0.7
Average Path Correlation	0.92977
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	51.753
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	55.2003
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • arrestin family protein binding • neurotransmitter receptor activity • dopamine neurotransmitter receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • dopamine neurotransmitter receptor activity, coupled via Gs • cation binding • ion binding • catecholamine binding • dopamine binding • small molecule binding • G-protein alpha-subunit binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • protein-containing complex binding • heterotrimeric G-protein binding • response to stimulus • response to chemical • response to xenobiotic stimulus • behavior • multicellular organismal process • system process • learning • learning or memory • nervous system process • feeding behavior • cognition • associative learning • conditioned taste aversion • D-glucose import
Gene Ontology	Biological Process	• response to stimulus • response to chemical • response to xenobiotic stimulus • behavior • multicellular organismal process • system process • learning • learning or memory • nervous system process • feeding behavior • cognition • associative learning • conditioned taste aversion • D-glucose import • hexose transmembrane transport • transport • carbohydrate transport • establishment of localization • transmembrane transport • localization • D-glucose transmembrane transport • cellular process • monosaccharide transmembrane transport • carbohydrate transmembrane transport • trans-synaptic signaling • regulation of biological process • regulation of signaling • regulation of cellular process • modulation of chemical synaptic transmission • signaling • biological regulation • cell-cell signaling • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • cell communication • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • reproductive process • multicellular organismal reproductive process • reproductive behavior • mating behavior • nonassociative learning • habituation • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • signal transduction • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • G protein-coupled receptor signaling pathway • memory • establishment of protein localization • cellular localization • nitrogen compound transport • nucleocytoplasmic transport • nuclear transport • intracellular transport • protein localization to nucleus • import into nucleus • establishment of protein localization to organelle • protein transport • establishment of localization in cell • macromolecule localization • protein localization to organelle • protein import into nucleus • intracellular protein localization • intracellular protein transport • cellular developmental process • forebrain development • central nervous system neuron development • cell development • substrate-independent telencephalic tangential migration • cerebral cortex GABAergic interneuron differentiation • interneuron migration • multicellular organism development • neurogenesis • central nervous system neuron differentiation • telencephalon cell migration • forebrain cell migration • neuron differentiation • cell differentiation • substrate-independent telencephalic tangential interneuron migration • cerebral cortex GABAergic interneuron migration • anatomical structure development • cell migration • cell motility • GABAergic neuron differentiation • system development • developmental process • head development • interneuron migration from the subpallium to the cortex • neuron migration • forebrain generation of neurons • animal organ development • brain development • nervous system development • cerebral cortex GABAergic interneuron development • generation of neurons • forebrain neuron development • central nervous system development • neuron development • telencephalon development • cerebral cortex neuron differentiation • forebrain neuron differentiation • astrocyte differentiation • glial cell development • astrocyte development • gliogenesis • glial cell differentiation • startle response • regulation of response to external stimulus • neuromuscular process • negative regulation of response to stimulus • negative regulation of biological process • prepulse inhibition • response to external stimulus • regulation of response to stimulus • negative regulation of response to external stimulus • regulation of localization • regulation of potassium ion transport • regulation of transport • regulation of monoatomic ion transport • positive regulation of biological process • metal ion transport • positive regulation of potassium ion transport • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • potassium ion transport • monoatomic cation transport • regulation of metal ion transport • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • transmission of nerve impulse • striatum development • subpallium development • adult walking behavior • adult locomotory behavior • adult behavior • locomotory behavior • walking behavior • adenylate cyclase-activating dopamine receptor signaling pathway • cellular component organization • cellular component biogenesis • cell junction organization • cellular component assembly • cell junction assembly • synapse organization • cellular component organization or biogenesis • synapse assembly • phospholipase C-activating dopamine receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • peristalsis • muscle system process • modification of postsynaptic structure • modification of synaptic structure • behavioral response to cocaine • response to cocaine • response to alkaloid • positive regulation of cell communication • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • positive regulation of cellular process • positive regulation of synaptic transmission • positive regulation of synaptic transmission, glutamatergic • positive regulation of signaling • maternal behavior • parental behavior • sensitization • positive regulation of locomotion • regulation of cell motility • regulation of neuron migration • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • locomotion • regulation of locomotion • positive regulation of neuron migration • monoamine transport • import into cell • regulation of catecholamine uptake involved in synaptic transmission • organic hydroxy compound transport • catecholamine uptake • dopamine transport • dopamine uptake involved in synaptic transmission • catecholamine transport • regulation of dopamine uptake involved in synaptic transmission • neurotransmitter reuptake • regulation of neurotransmitter uptake • catecholamine uptake involved in synaptic transmission • regulation of neurotransmitter transport • neurotransmitter transport • amine transport • neurotransmitter uptake • regulation of amine transport • synaptic transmission, dopaminergic • dopamine uptake • response to light stimulus • visual learning • visual behavior • response to radiation • response to abiotic stimulus • action potential • neuronal action potential • regulation of biological quality • regulation of membrane potential • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • dentate gyrus development • pallium development • hippocampus development • limbic system development • multicellular organismal-level homeostasis • homeostatic process • temperature homeostasis • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • maintenance of location • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • inorganic ion homeostasis • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • negative regulation of cellular process • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • cellular homeostasis • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • response to amine • response to amphetamine • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • negative regulation of signaling • negative regulation of synaptic transmission • negative regulation of cell communication • regulation of synaptic plasticity • long-term synaptic depression • operant conditioning • long-term synaptic potentiation • grooming behavior • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • plasma membrane protein complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • plasma membrane protein complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • membrane protein complex • receptor complex • presynapse • presynaptic membrane • glutamatergic synapse • neuron spine • neuron projection • dendritic spine • plasma membrane bounded cell projection • somatodendritic compartment • cell projection • dendrite • dendritic tree • membrane-bounded organelle • organelle • cilium • non-motile cilium • GABA-ergic synapse • ciliary membrane • bounding membrane of organelle • organelle membrane • cell projection membrane • intracellular anatomical structure • organelle subcompartment • intracellular membrane-bounded organelle • endomembrane system • endoplasmic reticulum subcompartment • intracellular organelle • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • cytoplasm • endoplasmic reticulum membrane • nucleus • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • trans-Golgi network membrane • trans-Golgi network • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	86W
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	86W
Name	Tavapadon
Synonyms	Tavapadon
Identifier
Formula	C19 H16 F3 N3 O3
Molecular Weight	391.344
SMILES
PubChem	86764100
Formal Charge	0
Total Atoms	44
Total Chiral Atoms	0
Total Bonds	46
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21728
Sequence	>7X2D_nogp_Chain_R F S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F R H L R S K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G F W P F G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S P F R Y E R K M T P K A A F I L I S V A W T L S V L I S F I P V Q L S W H K A K D N C D S S L S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C G F C I D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F R K A F S T L L G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9JF4	A	Peptide	Bombesin	BB₁	Homo sapiens	PD168368	-	-	3.6	2025-07-09	To be published
	7W41	A	Peptide	Bombesin	BB₂	Homo sapiens	PD176252	-	-	2.95	2023-02-22	doi.org/10.1073/pnas.2216230120
	7CKZ	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7LJC	A	Amine	Dopamine	D₁	Homo sapiens	SKF-81297	Mevidalen	Gs/β1/γ2	3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJC (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF-81297	Mevidalen		3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ1	3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7X2F	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2F (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7F1O	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg	Gs/β1/γ2	3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1O (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg		3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7X2C	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam	Gs/β1/γ2	3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7X2C (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam		3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7JV5	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JV5 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7CKW	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKW (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-		3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-	Gs/β1/γ2	3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-		3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-	Gs/β1/γ2	3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-		3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	8IRR	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-	Gs/β1/γ2	3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8IRR (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-		3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	7JOZ	A	Amine	Dopamine	D₁	Homo sapiens	VFP	-	Gs/β1/γ2	3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7JOZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	VFP	-		3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7X2D	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-	Gs/β1/γ2	3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2D (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-		3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7F0T	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-	Gs/β1/γ2	3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F0T (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-		3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	8JXR	A	Amine	Dopamine	D₁	Homo sapiens	LSD	-	-	3.57	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8JXS	A	Amine	Dopamine	D₁	Homo sapiens	PF-6142	-	-	3	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	7CMV	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-	Gi1/β1/γ2	2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7CMV (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-		2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	8JD1	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	-	-	3.7	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	4NTJ	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	AZD1283	-	-	2.62	2014-03-26	doi.org/10.1038/nature13083
	7AD3	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	Gi1/STE4/γ2	3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7AD3 (No Gprot)	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-		3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7QA8	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	Peptide	-	-	2.7	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QB9	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	-	-	-	3.1	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBC	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.53	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBI	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.46	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	9V0U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9V0U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9I52	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-	Gs/β1/γ2	2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I52 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-		2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54	A	Amine	Dopamine	D₁	Homo sapiens	A1IZV	-	Gs/β1/γ2	2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A1IZV	-		2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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