psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	17.64	Yes	Yes	1	0	7
2	L:L:?1	R:R:I104	14.84	Yes	No	0	0	6
3	L:L:?1	R:R:S107	5.86	Yes	No	1	0	7
4	L:L:?1	R:R:S188	6.83	Yes	No	0	0	5
5	L:L:?1	R:R:S198	6.83	Yes	No	0	0	7
6	L:L:?1	R:R:S202	5.86	Yes	No	0	0	6
7	L:L:?1	R:R:F288	18.21	Yes	Yes	1	0	7
8	L:L:?1	R:R:F289	10.29	Yes	Yes	1	0	7
9	L:L:?1	R:R:N292	7.14	Yes	No	1	0	6
10	L:L:?1	R:R:V317	14.52	Yes	No	1	0	6
11	L:L:?1	R:R:W321	8.14	Yes	Yes	1	0	7
12	R:R:F29	R:R:L30	4.87	No	Yes	0	3	7
13	R:R:F29	R:R:L33	4.87	No	No	0	3	7
14	R:R:L30	R:R:W318	14.81	Yes	No	0	7	5
15	R:R:I34	R:R:M78	5.83	No	Yes	0	6	7
16	R:R:N41	R:R:T37	4.39	No	Yes	0	9	7
17	R:R:M78	R:R:T37	9.03	Yes	Yes	0	7	7
18	R:R:S324	R:R:T37	6.4	No	Yes	0	9	7
19	R:R:S325	R:R:T37	6.4	No	Yes	0	6	7
20	R:R:L39	R:R:L43	6.92	No	Yes	0	4	7
21	R:R:D70	R:R:N41	8.08	Yes	No	0	9	9
22	R:R:N41	R:R:P328	4.89	No	No	0	9	9
23	R:R:A332	R:R:V44	5.09	No	No	0	6	9
24	R:R:I64	R:R:V48	9.22	No	No	0	6	8
25	R:R:F51	R:R:R50	9.62	Yes	No	0	6	6
26	R:R:A340	R:R:F51	4.16	No	Yes	0	7	6
27	R:R:R52	R:R:R55	10.66	No	No	0	7	8
28	R:R:H53	R:R:L54	6.43	No	No	0	6	9
29	R:R:D336	R:R:H53	5.04	No	No	0	7	6
30	R:R:F337	R:R:L54	12.18	Yes	No	0	9	9
31	R:R:K57	R:R:N60	4.2	No	No	0	5	9
32	R:R:F61	R:R:V58	9.18	No	No	0	4	6
33	R:R:M135	R:R:V58	4.56	Yes	No	0	7	6
34	R:R:N60	R:R:T59	5.85	No	No	0	9	8
35	R:R:D120	R:R:T59	5.78	Yes	No	0	9	8
36	R:R:F337	R:R:N60	6.04	Yes	No	0	9	9
37	R:R:F141	R:R:F61	9.65	No	No	0	3	4
38	R:R:F62	R:R:V116	5.24	Yes	No	0	8	7
39	R:R:D120	R:R:F62	10.75	Yes	Yes	4	9	8
40	R:R:F62	R:R:M135	4.98	Yes	Yes	4	8	7
41	R:R:A140	R:R:F62	4.16	No	Yes	0	7	8
42	R:R:F62	R:R:L143	4.87	Yes	No	0	8	7
43	R:R:F62	R:R:I144	5.02	Yes	No	0	8	8
44	R:R:N113	R:R:S65	7.45	No	No	2	8	9
45	R:R:I144	R:R:S65	9.29	No	No	0	8	9
46	R:R:S65	R:R:W148	4.94	No	Yes	2	9	9
47	R:R:D70	R:R:L66	8.14	Yes	Yes	2	9	9
48	R:R:L66	R:R:N113	5.49	Yes	No	2	9	8
49	R:R:L114	R:R:L66	5.54	No	Yes	2	9	9
50	R:R:L66	R:R:N327	10.98	Yes	Yes	2	9	9
51	R:R:L66	R:R:Y331	4.69	Yes	Yes	2	9	9
52	R:R:S110	R:R:S69	4.89	No	No	0	9	8
53	R:R:S69	R:R:W148	4.94	No	Yes	0	8	9
54	R:R:D70	R:R:S110	7.36	Yes	No	0	9	9
55	R:R:D70	R:R:S324	5.89	Yes	No	0	9	9
56	R:R:D70	R:R:N327	10.77	Yes	Yes	2	9	9
57	R:R:L72	R:R:L76	4.15	No	No	0	7	6
58	R:R:C106	R:R:L72	6.35	No	No	0	7	7
59	R:R:M78	R:R:V73	4.56	Yes	No	0	7	8
60	R:R:S324	R:R:V73	6.46	No	No	0	9	8
61	R:R:F102	R:R:L76	17.05	No	No	0	5	6
62	R:R:V77	R:R:W99	4.9	No	Yes	1	8	5
63	R:R:D103	R:R:V77	5.84	Yes	No	1	7	8
64	R:R:V77	R:R:W321	7.36	No	Yes	1	8	7
65	R:R:M78	R:R:W318	6.98	Yes	No	0	7	5
66	R:R:P79	R:R:W80	10.81	No	Yes	0	8	5
67	R:R:F92	R:R:W80	8.02	Yes	Yes	1	6	5
68	R:R:F95	R:R:W80	6.01	Yes	Yes	1	5	5
69	R:R:W80	R:R:W99	5.62	Yes	Yes	1	5	5
70	R:R:K81	R:R:W99	6.96	No	Yes	0	6	5
71	R:R:K81	R:R:W321	4.64	No	Yes	0	6	7
72	R:R:F92	R:R:V83	6.55	Yes	No	0	6	4
73	R:R:F92	R:R:W90	11.02	Yes	Yes	1	6	8
74	R:R:F95	R:R:W90	5.01	Yes	Yes	1	5	8
75	R:R:C96	R:R:W90	5.22	No	Yes	1	9	8
76	R:R:W90	R:R:W99	6.56	Yes	Yes	1	8	5
77	R:R:C186	R:R:W90	11.75	No	Yes	1	9	8
78	R:R:F92	R:R:P91	14.45	Yes	No	0	6	1
79	R:R:F92	R:R:F95	4.29	Yes	Yes	1	6	5
80	R:R:F95	R:R:I98	5.02	Yes	No	1	5	6
81	R:R:F95	R:R:W99	7.02	Yes	Yes	1	5	5
82	R:R:F102	R:R:F95	4.29	No	Yes	1	5	5
83	R:R:C186	R:R:C96	7.28	No	No	1	9	9
84	R:R:F102	R:R:I98	6.28	No	No	1	5	6
85	R:R:D103	R:R:W99	6.7	Yes	Yes	1	7	5
86	R:R:A101	R:R:F156	8.32	No	No	0	6	5
87	R:R:A101	R:R:V159	5.09	No	Yes	0	6	5
88	R:R:D103	R:R:S107	4.42	Yes	No	1	7	7
89	R:R:D103	R:R:W321	8.93	Yes	Yes	1	7	7
90	R:R:I104	R:R:S155	6.19	No	No	0	6	7
91	R:R:I104	R:R:Y194	4.84	No	Yes	0	6	7
92	R:R:M105	R:R:S155	4.6	No	No	0	5	7
93	R:R:S107	R:R:W285	7.41	No	Yes	0	7	8
94	R:R:S151	R:R:T108	6.4	No	No	0	8	6
95	R:R:I154	R:R:T108	4.56	No	No	0	5	6
96	R:R:S202	R:R:T108	6.4	No	No	0	6	6
97	R:R:A109	R:R:W148	7.78	No	Yes	0	7	9
98	R:R:I111	R:R:W285	17.62	No	Yes	0	8	8
99	R:R:L112	R:R:L150	4.15	No	No	0	5	4
100	R:R:N113	R:R:W148	4.52	No	Yes	2	8	9
101	R:R:L114	R:R:N327	9.61	No	Yes	2	9	9
102	R:R:L114	R:R:Y331	5.86	No	Yes	2	9	9
103	R:R:C115	R:R:I209	6.55	No	No	0	7	6
104	R:R:I117	R:R:R121	5.01	No	No	0	9	9
105	R:R:M210	R:R:S118	6.13	No	Yes	0	8	8
106	R:R:S118	R:R:T213	7.99	Yes	No	0	8	7
107	R:R:S118	R:R:Y214	7.63	Yes	Yes	0	8	9
108	R:R:D120	R:R:Y131	8.05	Yes	Yes	4	9	7
109	R:R:D120	R:R:M135	4.16	Yes	Yes	4	9	7
110	R:R:R121	R:R:Y331	5.14	No	Yes	0	9	9
111	R:R:S126	R:R:Y122	12.72	No	Yes	0	7	8
112	R:R:T213	R:R:Y122	6.24	No	Yes	0	7	8
113	R:R:R216	R:R:Y122	11.32	No	Yes	0	5	8
114	R:R:W123	R:R:Y131	5.79	No	Yes	0	4	7
115	R:R:A124	R:R:Y131	9.34	No	Yes	0	8	7
116	R:R:I125	R:R:I217	7.36	No	No	0	8	9
117	R:R:I125	R:R:I220	4.42	No	No	0	8	6
118	R:R:R130	R:R:S127	5.27	No	No	0	5	6
119	R:R:R130	R:R:R133	4.26	No	No	0	5	4
120	R:R:M135	R:R:Y131	14.37	Yes	Yes	4	7	7
121	R:R:I201	R:R:L150	4.28	No	No	0	4	4
122	R:R:I154	R:R:S198	6.19	No	No	0	5	7
123	R:R:P158	R:R:Y194	8.34	No	Yes	0	6	7
124	R:R:Q160	R:R:V159	4.3	No	Yes	0	5	5
125	R:R:H164	R:R:V159	12.45	Yes	Yes	0	5	5
126	R:R:L161	R:R:W163	7.97	No	No	0	4	6
127	R:R:K165	R:R:S162	4.59	No	No	0	3	5
128	R:R:H164	R:R:K165	5.24	Yes	No	0	5	3
129	R:R:H164	R:R:Y194	4.36	Yes	Yes	0	5	7
130	R:R:D187	R:R:N185	5.39	No	No	0	5	4
131	R:R:S198	R:R:Y194	13.99	No	Yes	0	7	7
132	R:R:F289	R:R:S199	5.28	Yes	No	0	7	7
133	R:R:N292	R:R:S199	5.96	No	No	0	6	7
134	R:R:F203	R:R:Y204	9.28	Yes	No	0	8	5
135	R:R:F203	R:R:V207	7.87	Yes	No	0	8	7
136	R:R:F203	R:R:F289	24.65	Yes	Yes	0	8	7
137	R:R:M210	R:R:M278	4.33	No	No	0	8	8
138	R:R:F281	R:R:M210	13.68	No	No	0	9	8
139	R:R:R216	R:R:V212	5.23	No	No	0	5	4
140	R:R:L274	R:R:Y214	4.69	No	Yes	0	8	9
141	R:R:I277	R:R:Y214	6.04	No	Yes	0	8	9
142	R:R:M278	R:R:Y214	7.18	No	Yes	0	8	9
143	R:R:Q222	R:R:Y218	19.16	No	Yes	0	6	7
144	R:R:L271	R:R:Y218	5.86	No	Yes	0	7	7
145	R:R:A221	R:R:V270	5.09	No	No	0	9	8
146	R:R:E267	R:R:Q222	11.47	No	No	0	8	6
147	R:R:Q224	R:R:R227	9.35	No	No	0	7	5
148	R:R:E267	R:R:I225	5.47	No	No	0	8	5
149	R:R:I228	R:R:R266	6.26	No	Yes	0	7	6
150	R:R:E232	R:R:R266	8.14	No	Yes	0	3	6
151	R:R:R266	R:R:S263	7.91	Yes	No	0	6	5
152	R:R:F264	R:R:T268	7.78	No	No	0	5	5
153	R:R:F281	R:R:W285	5.01	No	Yes	0	9	8
154	R:R:C284	R:R:N323	9.45	No	No	0	9	9
155	R:R:F289	R:R:W285	5.01	Yes	Yes	0	7	8
156	R:R:G320	R:R:W285	8.44	No	Yes	0	7	8
157	R:R:N323	R:R:W285	9.04	No	Yes	0	9	8
158	R:R:F316	R:R:P287	8.67	No	No	0	5	9
159	R:R:F288	R:R:F289	11.79	Yes	Yes	1	7	7
160	R:R:F288	R:R:N292	12.08	Yes	No	1	7	6
161	R:R:F288	R:R:F313	6.43	Yes	No	0	7	4
162	R:R:I308	R:R:L291	9.99	No	Yes	0	4	5
163	R:R:F316	R:R:L291	4.87	No	Yes	0	5	5
164	R:R:F313	R:R:L295	10.96	No	No	0	4	3
165	R:R:V317	R:R:W321	7.36	No	Yes	1	6	7
166	R:R:W318	R:R:W321	12.18	No	Yes	0	5	7
167	R:R:N323	R:R:N327	6.81	No	Yes	0	9	9
168	R:R:I330	R:R:Y331	13.3	No	Yes	0	8	9
169	R:R:A332	R:R:F337	5.55	No	Yes	0	6	9
170	R:R:F333	R:R:R338	4.28	No	No	0	8	8
171	R:R:F337	R:R:N334	13.29	Yes	No	0	9	8
172	R:R:F337	R:R:F341	5.36	Yes	No	3	9	7
173	R:R:C347	R:R:Y348	8.06	No	No	0	9	3
174	R:R:G40	R:R:P328	4.06	No	No	0	9	9
175	R:R:C293	R:R:Y204	4.03	No	No	0	6	5
176	R:R:R55	R:R:V48	3.92	No	No	0	8	8
177	R:R:F51	R:R:T343	3.89	Yes	No	0	6	4
178	R:R:H164	R:R:L190	3.86	Yes	No	0	5	4
179	R:R:S342	R:R:Y348	3.82	No	No	0	5	3
180	R:R:C115	R:R:P206	3.77	No	Yes	0	7	9
181	R:R:I225	R:R:R266	3.76	No	Yes	0	5	6
182	R:R:V68	R:R:W148	3.68	No	Yes	0	6	9
183	R:R:F203	R:R:L286	3.65	Yes	No	0	8	6
184	R:R:F313	R:R:L291	3.65	No	Yes	0	4	5
185	R:R:C298	R:R:C307	3.64	No	No	0	4	3
186	R:R:I217	R:R:Y122	3.63	No	Yes	0	9	8
187	R:R:P137	R:R:V58	3.53	No	No	0	1	6
188	R:R:L274	R:R:Y218	3.52	No	Yes	0	8	7
189	R:R:P137	R:R:T136	3.5	No	No	0	1	8
190	R:R:E267	R:R:F264	3.5	No	No	0	8	5
191	R:R:K134	R:R:W123	3.48	No	No	0	5	4
192	R:R:A166	R:R:S189	3.42	No	No	0	2	4
193	R:R:A229	R:R:S263	3.42	No	No	0	4	5
194	R:R:A67	R:R:V44	3.39	No	No	0	9	9
195	R:R:F51	R:R:H53	3.39	Yes	No	0	6	6
196	R:R:I111	R:R:P206	3.39	No	Yes	0	8	9
197	R:R:I157	R:R:P158	3.39	No	No	0	6	6
198	R:R:I205	R:R:P206	3.39	No	Yes	0	5	9
199	R:R:A74	R:R:T37	3.36	No	Yes	0	7	7
200	R:R:L112	R:R:P206	3.28	No	Yes	0	5	9
201	R:R:C293	R:R:I196	3.27	No	No	0	6	6
202	R:R:C307	R:R:I294	3.27	No	No	0	3	5
203	R:R:C307	R:R:I308	3.27	No	No	0	3	4
204	R:R:S325	R:R:S36	3.26	No	No	0	6	4
205	R:R:A27	R:R:I86	3.25	No	No	0	6	5
206	R:R:F297	R:R:R192	3.21	No	No	0	6	4
207	R:R:A82	R:R:L30	3.15	No	Yes	0	6	7
208	R:R:A74	R:R:L38	3.15	No	No	0	7	7
209	R:R:I205	R:R:V200	3.07	No	No	0	5	4
210	R:R:I211	R:R:V207	3.07	No	No	0	6	7
211	R:R:I225	R:R:V270	3.07	No	No	0	5	8
212	R:R:I330	R:R:V280	3.07	No	No	0	8	7
213	R:R:M105	R:R:V152	3.04	No	No	0	5	4
214	R:R:I308	R:R:T312	3.04	No	No	0	4	4
215	R:R:L32	R:R:S36	3	No	No	0	4	4
216	R:R:L71	R:R:V75	2.98	No	No	0	8	5
217	R:R:L76	R:R:V75	2.98	No	No	0	6	5
218	R:R:L326	R:R:V280	2.98	No	No	0	6	7
219	R:R:L286	R:R:V282	2.98	No	No	0	6	7
220	R:R:N97	R:R:V159	2.96	No	Yes	0	6	5
221	R:R:L30	R:R:T26	2.95	Yes	No	0	7	5
222	R:R:L71	R:R:T42	2.95	No	No	0	8	5
223	R:R:I142	R:R:K138	2.91	No	No	0	1	4
224	R:R:F89	R:R:P91	2.89	No	No	0	4	1
225	R:R:D309	R:R:T312	2.89	No	No	0	4	4
226	R:R:P296	R:R:R192	2.88	No	No	0	5	4
227	R:R:I157	R:R:L161	2.85	No	No	0	6	4
228	R:R:I290	R:R:L291	2.85	No	Yes	0	7	5
229	R:R:E85	R:R:T26	2.82	No	No	0	4	5
230	R:R:G93	R:R:W90	2.81	No	Yes	0	7	8
231	R:R:L35	R:R:L38	2.77	No	No	0	5	7
232	R:R:A47	R:R:F337	2.77	No	Yes	3	8	9
233	R:R:A47	R:R:F341	2.77	No	No	3	8	7
234	R:R:A87	R:R:F89	2.77	No	No	0	5	4
235	R:R:H164	R:R:V100	2.77	Yes	No	0	5	5
236	R:R:F337	R:R:V48	2.62	Yes	No	0	9	8
237	R:R:F337	R:R:V63	2.62	Yes	No	0	9	8
238	R:R:F316	R:R:V315	2.62	No	No	0	5	4
239	R:R:F319	R:R:V315	2.62	No	No	0	7	4
240	R:R:S191	R:R:Y194	2.54	No	Yes	0	5	7
241	R:R:F341	R:R:L43	2.44	No	Yes	3	7	7
242	R:R:N185	R:R:W90	2.26	No	Yes	0	4	8
243	R:R:H237	R:R:R233	2.26	No	No	0	1	1
244	R:R:A84	R:R:P91	1.87	No	No	0	5	1
245	R:R:A166	R:R:P168	1.87	No	No	0	2	1
246	R:R:A195	R:R:P296	1.87	No	No	0	5	5
247	R:R:A67	R:R:C45	1.81	No	No	0	9	7
248	R:R:P128	R:R:S127	1.78	No	No	0	8	6
249	L:L:?1	R:R:D314	1.76	Yes	No	0	0	4
250	R:R:A147	R:R:V116	1.7	No	No	0	7	7
251	R:R:A139	R:R:T136	1.68	No	No	0	6	8
252	R:R:K167	R:R:P168	1.67	No	No	0	2	1
253	R:R:L295	R:R:P296	1.64	No	No	0	3	5
254	R:R:S118	R:R:V119	1.62	Yes	No	0	8	6
255	R:R:V276	R:R:V280	1.6	No	No	0	7	7
256	R:R:T26	R:R:V22	1.59	No	No	0	5	4
257	R:R:A322	R:R:L33	1.58	No	No	0	4	7
258	R:R:A46	R:R:L344	1.58	No	No	0	5	6
259	R:R:A230	R:R:L231	1.58	No	No	0	4	4
260	R:R:I142	R:R:V146	1.54	No	No	0	1	3
261	R:R:I211	R:R:T215	1.52	No	No	0	6	3
262	R:R:I277	R:R:T273	1.52	No	No	0	8	9
263	R:R:K138	R:R:T136	1.5	No	No	0	4	8
264	R:R:K269	R:R:T273	1.5	No	No	0	8	9
265	R:R:N311	R:R:S310	1.49	No	No	0	1	1
266	R:R:N240	R:R:V236	1.48	No	No	0	4	4
267	R:R:L344	R:R:L43	1.38	No	Yes	3	6	7
268	R:R:L345	R:R:L43	1.38	No	Yes	3	7	7
269	R:R:L344	R:R:L345	1.38	No	No	3	6	7
270	R:R:R338	R:R:S342	1.32	No	No	0	8	5
271	R:R:S127	R:R:W123	1.24	No	No	0	6	4
272	R:R:K134	R:R:R133	1.24	No	No	0	5	4
273	R:R:R219	R:R:Y218	1.03	No	Yes	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.82667	12	1	0
2	R:R:L30	6.445	4	0	7
3	R:R:T37	5.916	5	0	7
4	R:R:L43	3.03	4	3	7
5	R:R:F51	5.265	4	0	6
6	R:R:F62	5.83667	6	4	8
7	R:R:L66	6.968	5	2	9
8	R:R:D70	8.048	5	2	9
9	R:R:M78	6.6	4	0	7
10	R:R:W80	7.615	4	1	5
11	R:R:W90	6.37571	7	1	8
12	R:R:F92	8.866	5	1	6
13	R:R:F95	5.27333	6	1	5
14	R:R:W99	6.29333	6	1	5
15	R:R:D103	8.706	5	1	7
16	R:R:S118	5.8425	4	0	8
17	R:R:D120	7.185	4	4	9
18	R:R:Y122	8.4775	4	0	8
19	R:R:Y131	9.3875	4	4	7
20	R:R:M135	7.0175	4	4	7
21	R:R:W148	5.172	5	2	9
22	R:R:V159	6.2	4	0	5
23	R:R:H164	5.736	5	0	5
24	R:R:Y194	6.814	5	0	7
25	R:R:F203	11.3625	4	0	8
26	R:R:P206	3.4575	4	0	9
27	R:R:Y214	6.385	4	0	9
28	R:R:Y218	7.3925	4	0	7
29	R:R:R266	6.5175	4	0	6
30	R:R:W285	8.755	6	0	8
31	R:R:F288	12.1275	4	1	7
32	R:R:F289	11.404	5	1	7
33	R:R:L291	5.34	4	0	5
34	R:R:W321	8.10167	6	1	7
35	R:R:N327	9.5425	4	2	9
36	R:R:Y331	7.2475	4	2	9
37	R:R:F337	6.30375	8	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W321	18.1578	8.14	Yes	Yes	1	0	7
2	R:R:W318	R:R:W321	32.4845	12.18	No	Yes	0	5	7
3	R:R:L30	R:R:W318	23.7199	14.81	Yes	No	0	7	5
4	R:R:M78	R:R:W318	27.4417	6.98	Yes	No	0	7	5
5	R:R:M78	R:R:T37	19.7522	9.03	Yes	Yes	0	7	7
6	R:R:N41	R:R:T37	12.377	4.39	No	Yes	0	9	7
7	R:R:S324	R:R:T37	10.6186	6.4	No	Yes	0	9	7
8	L:L:?1	R:R:S107	36.7119	5.86	Yes	No	1	0	7
9	R:R:S107	R:R:W285	68.5997	7.41	No	Yes	0	7	8
10	R:R:N323	R:R:W285	100	9.04	No	Yes	0	9	8
11	R:R:N323	R:R:N327	98.6334	6.81	No	Yes	0	9	9
12	R:R:L66	R:R:N327	79.8333	10.98	Yes	Yes	2	9	9
13	R:R:L66	R:R:N113	91.7411	5.49	Yes	No	2	9	8
14	R:R:N113	R:R:S65	86.4204	7.45	No	No	2	8	9
15	R:R:I144	R:R:S65	86.6937	9.29	No	No	0	8	9
16	R:R:F62	R:R:I144	85.5457	5.02	Yes	No	0	8	8
17	R:R:D120	R:R:F62	53.5942	10.75	Yes	Yes	4	9	8
18	R:R:D120	R:R:T59	42.9801	5.78	Yes	No	0	9	8
19	R:R:N60	R:R:T59	41.568	5.85	No	No	0	9	8
20	R:R:F337	R:R:N60	38.7163	6.04	Yes	No	0	9	9
21	L:L:?1	R:R:F289	41.7183	10.29	Yes	Yes	1	0	7
22	R:R:F289	R:R:W285	59.1153	5.01	Yes	Yes	0	7	8
23	R:R:F337	R:R:L54	11.4113	12.18	Yes	No	0	9	9
24	R:R:F62	R:R:M135	26.0705	4.98	Yes	Yes	4	8	7
25	R:R:M135	R:R:V58	14.5909	4.56	Yes	No	0	7	6
26	R:R:L66	R:R:Y331	11.5889	4.69	Yes	Yes	2	9	9
27	L:L:?1	R:R:D103	13.2972	17.64	Yes	Yes	1	0	7
28	R:R:D103	R:R:W99	42.8298	6.7	Yes	Yes	1	7	5
29	R:R:F95	R:R:W99	21.3147	7.02	Yes	Yes	1	5	5
30	R:R:F102	R:R:F95	10.4227	4.29	No	Yes	1	5	5
31	R:R:W80	R:R:W99	11.4204	5.62	Yes	Yes	1	5	5
32	R:R:W90	R:R:W99	17.1055	6.56	Yes	Yes	1	8	5
33	R:R:F92	R:R:P91	17.397	14.45	Yes	No	0	6	1
34	L:L:?1	R:R:I104	36.9215	14.84	Yes	No	0	0	6
35	R:R:I104	R:R:Y194	29.8515	4.84	No	Yes	0	6	7
36	R:R:H164	R:R:Y194	37.6184	4.36	Yes	Yes	0	5	7
37	R:R:H164	R:R:V159	18.9687	12.45	Yes	Yes	0	5	5
38	L:L:?1	R:R:S198	33.3591	6.83	Yes	No	0	0	7
39	R:R:S198	R:R:Y194	29.9426	13.99	No	Yes	0	7	7
40	R:R:I111	R:R:W285	14.8734	17.62	No	Yes	0	8	8
41	R:R:I111	R:R:P206	13.2471	3.39	No	Yes	0	8	9
42	R:R:F281	R:R:W285	77.2185	5.01	No	Yes	0	9	8
43	R:R:F281	R:R:M210	75.9931	13.68	No	No	0	9	8
44	R:R:M210	R:R:S118	44.0962	6.13	No	Yes	0	8	8
45	R:R:S118	R:R:T213	12.6412	7.99	Yes	No	0	8	7
46	R:R:S118	R:R:Y214	30.2934	7.63	Yes	Yes	0	8	9
47	R:R:M210	R:R:M278	30.7489	4.33	No	No	0	8	8
48	R:R:M278	R:R:Y214	29.3686	7.18	No	Yes	0	8	9
49	R:R:D120	R:R:Y131	12.6412	8.05	Yes	Yes	4	9	7
50	R:R:M135	R:R:Y131	11.9488	14.37	Yes	Yes	4	7	7
51	R:R:T213	R:R:Y122	11.0924	6.24	No	Yes	0	7	8
52	R:R:W123	R:R:Y131	18.4995	5.79	No	Yes	0	4	7
53	R:R:P158	R:R:Y194	15.1922	8.34	No	Yes	0	6	7
54	R:R:I157	R:R:P158	11.4067	3.39	No	No	0	6	6
55	R:R:F203	R:R:F289	11.762	24.65	Yes	Yes	0	8	7
56	R:R:L274	R:R:Y214	47.8954	4.69	No	Yes	0	8	9
57	R:R:L274	R:R:Y218	44.9526	3.52	No	Yes	0	8	7
58	R:R:Q222	R:R:Y218	36.0696	19.16	No	Yes	0	6	7
59	R:R:E267	R:R:Q222	33.0858	11.47	No	No	0	8	6
60	R:R:E267	R:R:I225	24.2666	5.47	No	No	0	8	5
61	R:R:I225	R:R:R266	15.1831	3.76	No	Yes	0	5	6
62	R:R:F288	R:R:F313	23.0366	6.43	Yes	No	0	7	4
63	R:R:F313	R:R:L291	15.6842	3.65	No	Yes	0	4	5
64	R:R:I330	R:R:Y331	11.0559	13.3	No	Yes	0	8	9
65	R:R:D103	R:R:S107	31.8149	4.42	Yes	No	1	7	7
66	R:R:D70	R:R:N41	12.1583	8.08	Yes	No	0	9	9
67	R:R:D70	R:R:S324	16.1261	5.89	Yes	No	0	9	9
68	R:R:F288	R:R:F289	15.1877	11.79	Yes	Yes	1	7	7
69	R:R:D70	R:R:L66	20.1895	8.14	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D103	17.64	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:I104	14.84	1	Yes	No	0	6	0	1
L:L:?1	R:R:S107	5.86	1	Yes	No	0	7	0	1
L:L:?1	R:R:S188	6.83	1	Yes	No	0	5	0	1
L:L:?1	R:R:S198	6.83	1	Yes	No	0	7	0	1
L:L:?1	R:R:S202	5.86	1	Yes	No	0	6	0	1
L:L:?1	R:R:F288	18.21	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F289	10.29	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N292	7.14	1	Yes	No	0	6	0	1
L:L:?1	R:R:V317	14.52	1	Yes	No	0	6	0	1
L:L:?1	R:R:W321	8.14	1	Yes	Yes	0	7	0	1
R:R:V77	R:R:W99	4.9	1	No	Yes	8	5	2	2
R:R:D103	R:R:V77	5.84	1	Yes	No	7	8	1	2
R:R:V77	R:R:W321	7.36	1	No	Yes	8	7	2	1
R:R:K81	R:R:W99	6.96	0	No	Yes	6	5	2	2
R:R:K81	R:R:W321	4.64	0	No	Yes	6	7	2	1
R:R:D103	R:R:W99	6.7	1	Yes	Yes	7	5	1	2
R:R:D103	R:R:S107	4.42	1	Yes	No	7	7	1	1
R:R:D103	R:R:W321	8.93	1	Yes	Yes	7	7	1	1
R:R:I104	R:R:S155	6.19	0	No	No	6	7	1	2
R:R:I104	R:R:Y194	4.84	0	No	Yes	6	7	1	2
R:R:S107	R:R:W285	7.41	1	No	Yes	7	8	1	2
R:R:I154	R:R:T108	4.56	0	No	No	5	6	2	2
R:R:S202	R:R:T108	6.4	0	No	No	6	6	1	2
R:R:I154	R:R:S198	6.19	0	No	No	5	7	2	1
R:R:S198	R:R:Y194	13.99	0	No	Yes	7	7	1	2
R:R:F289	R:R:S199	5.28	1	Yes	No	7	7	1	2
R:R:N292	R:R:S199	5.96	1	No	No	6	7	1	2
R:R:F203	R:R:F289	24.65	0	Yes	Yes	8	7	2	1
R:R:F289	R:R:W285	5.01	1	Yes	Yes	7	8	1	2
R:R:F288	R:R:F289	11.79	1	Yes	Yes	7	7	1	1
R:R:F288	R:R:N292	12.08	1	Yes	No	7	6	1	1
R:R:F288	R:R:F313	6.43	1	Yes	No	7	4	1	2
R:R:V317	R:R:W321	7.36	1	No	Yes	6	7	1	1
R:R:W318	R:R:W321	12.18	0	No	Yes	5	7	2	1
L:L:?1	R:R:D314	1.76	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IRR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.14
Number of Linked Nodes	250
Number of Links	273
Number of Hubs	37
Number of Links mediated by Hubs	152
Number of Communities	4
Number of Nodes involved in Communities	36
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	54627
Length Of Smallest Path	3
Average Path Length	13.0639
Length of Longest Path	28
Minimum Path Strength	1.48
Average Path Strength	7.46933
Maximum Path Strength	18.22
Minimum Path Correlation	0.7
Average Path Correlation	0.938008
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	57.3323
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.0615
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • arrestin family protein binding • neurotransmitter receptor activity • dopamine neurotransmitter receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • dopamine neurotransmitter receptor activity, coupled via Gs • cation binding • ion binding • catecholamine binding • dopamine binding • small molecule binding • G-protein alpha-subunit binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • protein-containing complex binding • heterotrimeric G-protein binding • response to stimulus • response to chemical • response to xenobiotic stimulus • behavior • multicellular organismal process • system process • learning • learning or memory • nervous system process • feeding behavior • cognition • associative learning • conditioned taste aversion • trans-synaptic signaling
Gene Ontology	Biological Process	• response to stimulus • response to chemical • response to xenobiotic stimulus • behavior • multicellular organismal process • system process • learning • learning or memory • nervous system process • feeding behavior • cognition • associative learning • conditioned taste aversion • trans-synaptic signaling • regulation of biological process • regulation of signaling • regulation of cellular process • modulation of chemical synaptic transmission • signaling • biological regulation • cell-cell signaling • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • cell communication • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • cellular process • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • reproductive process • multicellular organismal reproductive process • reproductive behavior • mating behavior • nonassociative learning • habituation • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • signal transduction • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • G protein-coupled receptor signaling pathway • memory • establishment of protein localization • cellular localization • nucleocytoplasmic transport • transport • nuclear transport • intracellular transport • protein localization to nucleus • establishment of localization • localization • import into nucleus • establishment of protein localization to organelle • protein transport • establishment of localization in cell • macromolecule localization • protein localization to organelle • protein import into nucleus • intracellular protein localization • intracellular protein transport • cellular developmental process • forebrain development • central nervous system neuron development • cell development • substrate-independent telencephalic tangential migration • cerebral cortex GABAergic interneuron differentiation • interneuron migration • multicellular organism development • neurogenesis • central nervous system neuron differentiation • telencephalon cell migration • forebrain cell migration • neuron differentiation • cell differentiation • substrate-independent telencephalic tangential interneuron migration • cerebral cortex GABAergic interneuron migration • anatomical structure development • cell migration • cell motility • GABAergic neuron differentiation • system development • developmental process • head development • interneuron migration from the subpallium to the cortex • neuron migration • forebrain generation of neurons • animal organ development • brain development • nervous system development • cerebral cortex GABAergic interneuron development • generation of neurons • forebrain neuron development • central nervous system development • neuron development • telencephalon development • cerebral cortex neuron differentiation • forebrain neuron differentiation • astrocyte differentiation • glial cell development • astrocyte development • gliogenesis • glial cell differentiation • regulation of localization • regulation of potassium ion transport • regulation of transport • regulation of monoatomic ion transport • positive regulation of biological process • metal ion transport • positive regulation of potassium ion transport • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • potassium ion transport • monoatomic cation transport • regulation of metal ion transport • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • transmission of nerve impulse • striatum development • subpallium development • adult walking behavior • adult locomotory behavior • adult behavior • locomotory behavior • walking behavior • adenylate cyclase-activating dopamine receptor signaling pathway • cellular component organization • cellular component biogenesis • cell junction organization • cellular component assembly • cell junction assembly • synapse organization • cellular component organization or biogenesis • synapse assembly • phospholipase C-activating dopamine receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • peristalsis • muscle system process • modification of postsynaptic structure • modification of synaptic structure • behavioral response to cocaine • response to cocaine • response to alkaloid • positive regulation of cell communication • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • positive regulation of cellular process • positive regulation of synaptic transmission • positive regulation of synaptic transmission, glutamatergic • positive regulation of signaling • maternal behavior • parental behavior • sensitization • positive regulation of locomotion • regulation of cell motility • regulation of neuron migration • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • locomotion • regulation of locomotion • positive regulation of neuron migration • monoamine transport • import into cell • nitrogen compound transport • organic hydroxy compound transport • dopamine transport • catecholamine uptake • dopamine uptake involved in synaptic transmission • catecholamine transport • regulation of dopamine uptake involved in synaptic transmission • neurotransmitter reuptake • regulation of neurotransmitter uptake • regulation of neurotransmitter transport • neurotransmitter transport • neurotransmitter uptake • synaptic transmission, dopaminergic • dopamine uptake • response to light stimulus • visual learning • visual behavior • response to radiation • response to abiotic stimulus • action potential • neuronal action potential • regulation of biological quality • regulation of membrane potential • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • dentate gyrus development • pallium development • hippocampus development • limbic system development • multicellular organismal-level homeostasis • homeostatic process • temperature homeostasis • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • monoatomic ion transmembrane transport • regulation of monoatomic ion transmembrane transport • calcium ion transport • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • positive regulation of monoatomic ion transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • calcium ion transmembrane import into cytosol • regulation of release of sequestered calcium ion into cytosol • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • response to amine • response to amphetamine • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • negative regulation of signaling • negative regulation of biological process • negative regulation of synaptic transmission • negative regulation of cell communication • negative regulation of cellular process • regulation of synaptic plasticity • long-term synaptic depression • operant conditioning • long-term synaptic potentiation • grooming behavior • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • plasma membrane protein complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • plasma membrane protein complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • membrane protein complex • receptor complex • presynapse • presynaptic membrane • glutamatergic synapse • neuron spine • neuron projection • dendritic spine • plasma membrane bounded cell projection • somatodendritic compartment • cell projection • dendrite • dendritic tree • membrane-bounded organelle • organelle • cilium • non-motile cilium • GABA-ergic synapse • ciliary membrane • bounding membrane of organelle • organelle membrane • cell projection membrane • intracellular anatomical structure • organelle subcompartment • intracellular membrane-bounded organelle • endomembrane system • endoplasmic reticulum subcompartment • intracellular organelle • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • cytoplasm • endoplasmic reticulum membrane • nucleus • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	R5F
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	R5F
Name	Rotigotine
Synonyms	(6~{S})-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol
Identifier
Formula	C19 H25 N O S
Molecular Weight	315.473
SMILES
PubChem	59227
Formal Charge	0
Total Atoms	47
Total Chiral Atoms	1
Total Bonds	49
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21728
Sequence	>8IRR_nogp_Chain_R S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F R H L R S K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G F W P F G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S P F R Y E R K M T P K A A F I L I S V A W T L S V L I S F I P V Q L S W H K A K P N C D S S L S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C C I D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F R K A F S T L L G C Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4NTJ	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	AZD1283	-	-	2.62	2014-03-26	doi.org/10.1038/nature13083
	7AD3	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	Gi1/STE4/γ2	3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7AD3 (No Gprot)	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-		3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7JV5	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JV5 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7CKW	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKW (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-		3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-	Gs/β1/γ2	3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-		3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-	Gs/β1/γ2	3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-		3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKZ	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7LJC	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	Mevidalen	Gs/β1/γ2	3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJC (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	Mevidalen		3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ1	3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7CMV	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-	Gi1/β1/γ2	2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7CMV (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-		2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7JOZ	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 75202022	-	Gs/β1/γ2	3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7JOZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 75202022	-		3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7QA8	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	Antagonist Peptide	-	-	2.7	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QB9	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	-	-	-	3.1	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBC	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.53	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBI	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.46	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7F0T	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-	Gs/β1/γ2	3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F0T (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-		3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1O	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg	Gs/β1/γ2	3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1O (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg		3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7X2D	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-	Gs/β1/γ2	3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2D (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-		3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2F	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2F (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2C	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam	Gs/β1/γ2	3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7X2C (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam		3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7W41	A	Peptide	Bombesin	BB₂	Homo sapiens	PD176252	-	-	2.95	2023-02-22	doi.org/10.1073/pnas.2216230120
	8IRR	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-	Gs/β1/γ2	3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8IRR (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-		3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8JD1	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	-	-	3.7	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8JXR	A	Amine	Dopamine	D₁	Homo sapiens	LSD	-	-	3.57	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8JXS	A	Amine	Dopamine	D₁	Homo sapiens	PF-6142	-	-	3	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JF4	A	Peptide	Bombesin	BB₁	Homo sapiens	PD168368	-	-	3.6	2025-07-09	To be published
	9I52	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-	Gs/β1/γ2	2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I52 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-		2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 176452091	-	Gs/β1/γ2	2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 176452091	-		2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9V0U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9V0U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

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