psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	10.96	Yes	Yes	1	0	7
2	L:L:?1	R:R:I104	12.81	Yes	No	0	0	6
3	L:L:?1	R:R:S107	6.74	Yes	No	1	0	7
4	L:L:?1	R:R:T108	3.97	Yes	No	0	0	6
5	L:L:?1	R:R:L190	3.73	Yes	No	1	0	4
6	L:L:?1	R:R:S198	10.78	Yes	Yes	0	0	7
7	L:L:?1	R:R:F288	13.11	Yes	Yes	1	0	7
8	L:L:?1	R:R:F289	7.65	Yes	Yes	1	0	7
9	L:L:?1	R:R:N292	9.86	Yes	Yes	1	0	6
10	I:I:?1	O:O:?1	7.23	No	No	0	0	0
11	R:R:F20	R:R:V22	5.24	No	No	0	1	4
12	R:R:A27	R:R:I86	4.87	No	No	0	6	5
13	R:R:F29	R:R:L33	8.53	No	No	0	3	7
14	R:R:A82	R:R:L30	4.73	No	No	0	6	7
15	R:R:L30	R:R:W318	6.83	No	Yes	0	7	5
16	R:R:I34	R:R:M78	4.37	No	Yes	0	6	7
17	R:R:I34	R:R:P79	6.77	No	No	0	6	8
18	R:R:M78	R:R:T37	7.53	Yes	No	0	7	7
19	R:R:S325	R:R:T37	6.4	No	No	0	6	7
20	R:R:L38	R:R:L71	4.15	No	No	0	7	8
21	R:R:G40	R:R:L39	3.42	No	No	0	9	4
22	R:R:L39	R:R:L43	4.15	No	No	0	4	7
23	R:R:D70	R:R:N41	8.08	Yes	No	0	9	9
24	R:R:L71	R:R:N41	4.12	No	No	0	8	9
25	R:R:N41	R:R:P328	9.77	No	No	0	9	9
26	R:R:L345	R:R:L43	5.54	No	No	0	7	7
27	R:R:A67	R:R:V44	3.39	No	No	0	9	9
28	R:R:R55	R:R:V48	3.92	No	No	0	8	8
29	R:R:I64	R:R:V48	10.75	No	No	0	6	8
30	R:R:F51	R:R:H53	4.53	Yes	No	0	6	6
31	R:R:R52	R:R:R55	7.46	No	No	0	7	8
32	R:R:H53	R:R:L54	5.14	No	No	0	6	9
33	R:R:H53	R:R:K339	7.86	No	No	0	6	5
34	R:R:D336	R:R:L54	5.43	No	No	0	7	9
35	R:R:F337	R:R:L54	7.31	Yes	No	0	9	9
36	R:R:K57	R:R:N60	4.2	No	No	0	5	9
37	R:R:D120	R:R:T59	5.78	No	No	0	9	8
38	R:R:F337	R:R:N60	3.62	Yes	No	0	9	9
39	R:R:F62	R:R:V116	6.55	Yes	No	0	8	7
40	R:R:D120	R:R:F62	9.55	No	Yes	0	9	8
41	R:R:F62	R:R:M135	3.73	Yes	No	0	8	7
42	R:R:F62	R:R:L143	4.87	Yes	No	0	8	7
43	R:R:F62	R:R:I144	3.77	Yes	No	0	8	8
44	R:R:N113	R:R:S65	10.43	No	No	0	8	9
45	R:R:I144	R:R:S65	6.19	No	No	0	8	9
46	R:R:S65	R:R:W148	4.94	No	Yes	0	9	9
47	R:R:D70	R:R:L66	4.07	Yes	Yes	1	9	9
48	R:R:L66	R:R:N113	4.12	Yes	No	0	9	8
49	R:R:L114	R:R:L66	5.54	Yes	Yes	1	9	9
50	R:R:L66	R:R:N327	10.98	Yes	Yes	1	9	9
51	R:R:L66	R:R:Y331	3.52	Yes	Yes	1	9	9
52	R:R:A109	R:R:S69	3.42	No	No	2	7	8
53	R:R:S69	R:R:W148	4.94	No	Yes	2	8	9
54	R:R:D70	R:R:S110	5.89	Yes	No	0	9	9
55	R:R:D70	R:R:S324	4.42	Yes	No	0	9	9
56	R:R:D70	R:R:N327	8.08	Yes	Yes	1	9	9
57	R:R:L72	R:R:W148	3.42	No	Yes	0	7	9
58	R:R:C106	R:R:V73	3.42	No	No	0	7	8
59	R:R:V73	R:R:W321	3.68	No	Yes	0	8	7
60	R:R:S324	R:R:V73	9.7	No	No	0	9	8
61	R:R:F102	R:R:L76	14.61	No	No	0	5	6
62	R:R:V77	R:R:W99	4.9	Yes	Yes	1	8	5
63	R:R:D103	R:R:V77	5.84	Yes	Yes	1	7	8
64	R:R:C106	R:R:V77	3.42	No	Yes	0	7	8
65	R:R:V77	R:R:W321	4.9	Yes	Yes	1	8	7
66	R:R:M78	R:R:W318	5.82	Yes	Yes	1	7	5
67	R:R:M78	R:R:W321	8.14	Yes	Yes	1	7	7
68	R:R:F92	R:R:W80	7.02	Yes	No	1	6	5
69	R:R:F95	R:R:W80	7.02	Yes	No	1	5	5
70	R:R:W80	R:R:W99	5.62	No	Yes	1	5	5
71	R:R:K81	R:R:W99	6.96	No	Yes	0	6	5
72	R:R:D314	R:R:K81	9.68	No	No	0	4	6
73	R:R:K81	R:R:W321	4.64	No	Yes	0	6	7
74	R:R:F92	R:R:V83	5.24	Yes	No	0	6	4
75	R:R:A84	R:R:W90	3.89	No	Yes	0	5	8
76	R:R:D314	R:R:E85	9.09	No	No	0	4	4
77	R:R:F89	R:R:P91	5.78	No	No	0	4	1
78	R:R:P91	R:R:W90	4.05	No	Yes	1	1	8
79	R:R:F92	R:R:W90	17.04	Yes	Yes	1	6	8
80	R:R:F95	R:R:W90	4.01	Yes	Yes	1	5	8
81	R:R:C96	R:R:W90	9.14	No	Yes	0	9	8
82	R:R:W90	R:R:W99	5.62	Yes	Yes	1	8	5
83	R:R:F92	R:R:P91	10.11	Yes	No	1	6	1
84	R:R:F92	R:R:F95	4.29	Yes	Yes	1	6	5
85	R:R:F95	R:R:W99	7.02	Yes	Yes	1	5	5
86	R:R:C186	R:R:C96	7.28	No	No	0	9	9
87	R:R:N97	R:R:V159	4.43	No	No	0	6	5
88	R:R:F102	R:R:I98	5.02	No	No	0	5	6
89	R:R:S188	R:R:V100	4.85	No	No	0	5	5
90	R:R:A101	R:R:F156	5.55	No	Yes	0	6	5
91	R:R:A101	R:R:V159	5.09	No	No	0	6	5
92	R:R:F102	R:R:F156	5.36	No	Yes	0	5	5
93	R:R:D103	R:R:S107	4.42	Yes	No	1	7	7
94	R:R:D103	R:R:W321	5.58	Yes	Yes	1	7	7
95	R:R:I104	R:R:Y194	7.25	No	Yes	0	6	7
96	R:R:M105	R:R:S155	4.6	No	No	0	5	7
97	R:R:S107	R:R:W285	3.71	No	Yes	1	7	8
98	R:R:S202	R:R:T108	9.59	No	No	0	6	6
99	R:R:A109	R:R:W148	7.78	No	Yes	2	7	9
100	R:R:A109	R:R:S151	3.42	No	No	2	7	8
101	R:R:I111	R:R:S202	6.19	Yes	No	0	8	6
102	R:R:I111	R:R:P206	3.39	Yes	Yes	0	8	9
103	R:R:F281	R:R:I111	5.02	Yes	Yes	0	9	8
104	R:R:I111	R:R:W285	10.57	Yes	Yes	0	8	8
105	R:R:F281	R:R:L114	3.65	Yes	Yes	1	9	9
106	R:R:L114	R:R:N327	8.24	Yes	Yes	1	9	9
107	R:R:L114	R:R:Y331	4.69	Yes	Yes	1	9	9
108	R:R:C115	R:R:P206	5.65	No	Yes	0	7	9
109	R:R:C115	R:R:I209	6.55	No	No	0	7	6
110	R:R:I117	R:R:R121	3.76	No	Yes	1	9	9
111	R:R:I117	R:R:Y331	6.04	No	Yes	1	9	9
112	R:R:M210	R:R:S118	7.67	No	No	0	8	8
113	R:R:S118	R:R:T213	6.4	No	No	0	8	7
114	R:R:S118	R:R:Y214	3.82	No	Yes	0	8	9
115	R:R:V119	R:R:W123	7.36	No	No	0	6	4
116	R:R:D120	R:R:Y131	4.6	No	Yes	0	9	7
117	R:R:R121	R:R:Y214	6.17	Yes	Yes	1	9	9
118	R:R:I277	R:R:R121	3.76	Yes	Yes	1	8	9
119	R:R:R121	R:R:Y331	5.14	Yes	Yes	1	9	9
120	R:R:S126	R:R:Y122	16.53	No	Yes	0	7	8
121	R:R:T213	R:R:Y122	7.49	No	Yes	0	7	8
122	R:R:R216	R:R:Y122	13.38	No	Yes	0	5	8
123	R:R:I217	R:R:Y122	3.63	No	Yes	0	9	8
124	R:R:A124	R:R:Y131	9.34	No	Yes	0	8	7
125	R:R:I125	R:R:I220	4.42	No	No	0	8	6
126	R:R:R130	R:R:S127	5.27	No	No	0	5	6
127	R:R:M135	R:R:Y131	7.18	No	Yes	0	7	7
128	R:R:P137	R:R:T136	3.5	No	No	0	1	8
129	R:R:S151	R:R:W148	4.94	No	Yes	2	8	9
130	R:R:I154	R:R:S198	4.64	No	Yes	0	5	7
131	R:R:F156	R:R:S155	5.28	Yes	No	0	5	7
132	R:R:F156	R:R:Q160	3.51	Yes	No	0	5	5
133	R:R:I157	R:R:P158	3.39	No	No	0	6	6
134	R:R:P158	R:R:Y194	9.74	No	Yes	0	6	7
135	R:R:H164	R:R:V159	9.69	Yes	No	0	5	5
136	R:R:L161	R:R:W163	10.25	No	No	0	4	6
137	R:R:H164	R:R:K165	5.24	Yes	No	0	5	3
138	R:R:H164	R:R:Y194	4.36	Yes	Yes	0	5	7
139	R:R:A166	R:R:S191	3.42	No	No	0	2	5
140	R:R:L190	R:R:Y194	5.86	No	Yes	0	4	7
141	R:R:L190	R:R:N292	4.12	No	Yes	1	4	6
142	R:R:F297	R:R:R192	24.59	No	No	0	6	4
143	R:R:S198	R:R:Y194	7.63	Yes	Yes	0	7	7
144	R:R:F297	R:R:I196	5.02	No	No	0	6	6
145	R:R:S199	R:R:Y204	5.09	No	Yes	1	7	5
146	R:R:F289	R:R:S199	3.96	Yes	No	1	7	7
147	R:R:C293	R:R:S199	3.44	No	No	1	6	7
148	R:R:V200	R:R:Y204	3.79	No	Yes	0	4	5
149	R:R:F203	R:R:Y204	11.35	Yes	Yes	1	8	5
150	R:R:F203	R:R:V207	6.55	Yes	No	1	8	7
151	R:R:F203	R:R:F281	8.57	Yes	Yes	1	8	9
152	R:R:F203	R:R:W285	4.01	Yes	Yes	1	8	8
153	R:R:F203	R:R:L286	7.31	Yes	No	0	8	6
154	R:R:F203	R:R:F289	18.22	Yes	Yes	1	8	7
155	R:R:C293	R:R:Y204	4.03	No	Yes	1	6	5
156	R:R:I205	R:R:P206	3.39	No	Yes	0	5	9
157	R:R:F281	R:R:V207	5.24	Yes	No	1	9	7
158	R:R:R216	R:R:V212	3.92	No	No	0	5	4
159	R:R:L274	R:R:Y214	5.86	No	Yes	0	8	9
160	R:R:I277	R:R:Y214	4.84	Yes	Yes	1	8	9
161	R:R:M278	R:R:Y214	3.59	No	Yes	0	8	9
162	R:R:R219	R:R:T215	3.88	No	No	0	4	3
163	R:R:V270	R:R:Y218	3.79	No	Yes	0	8	7
164	R:R:L271	R:R:Y218	4.69	No	Yes	0	7	7
165	R:R:L274	R:R:Y218	3.52	No	Yes	0	8	7
166	R:R:A221	R:R:V270	3.39	No	No	0	9	8
167	R:R:Q222	R:R:R226	18.69	No	No	0	6	5
168	R:R:E267	R:R:Q222	6.37	No	No	0	8	6
169	R:R:Q224	R:R:R227	8.18	No	No	0	7	5
170	R:R:I225	R:R:R266	6.26	No	Yes	0	5	6
171	R:R:I228	R:R:R266	3.76	No	Yes	0	7	6
172	R:R:E232	R:R:R266	6.98	No	Yes	0	3	6
173	R:R:E267	R:R:F264	16.32	No	No	0	8	5
174	R:R:K269	R:R:K272	8.62	No	No	0	8	7
175	R:R:K269	R:R:T273	4.5	No	No	0	8	9
176	R:R:I277	R:R:Y331	3.63	Yes	Yes	1	8	9
177	R:R:C284	R:R:N323	7.87	No	No	0	9	9
178	R:R:F288	R:R:W285	4.01	Yes	Yes	1	7	8
179	R:R:F289	R:R:W285	6.01	Yes	Yes	1	7	8
180	R:R:G320	R:R:W285	8.44	No	Yes	0	7	8
181	R:R:N323	R:R:W285	9.04	No	Yes	0	9	8
182	R:R:F316	R:R:P287	7.22	No	No	0	5	9
183	R:R:F288	R:R:F289	7.5	Yes	Yes	1	7	7
184	R:R:F288	R:R:N292	4.83	Yes	Yes	1	7	6
185	R:R:F288	R:R:F313	6.43	Yes	Yes	0	7	4
186	R:R:I308	R:R:L291	4.28	No	No	0	4	5
187	R:R:F313	R:R:L291	3.65	Yes	No	0	4	5
188	R:R:F316	R:R:L291	4.87	No	No	0	5	5
189	R:R:L295	R:R:P296	8.21	No	No	0	3	5
190	R:R:F313	R:R:L295	4.87	Yes	No	0	4	3
191	R:R:C298	R:R:F306	5.59	No	No	0	4	1
192	R:R:C298	R:R:C307	3.64	No	No	3	4	3
193	R:R:I308	R:R:T312	7.6	No	No	0	4	4
194	R:R:F313	R:R:V317	3.93	Yes	No	0	4	6
195	R:R:D314	R:R:W318	6.7	No	Yes	0	4	5
196	R:R:V317	R:R:W321	7.36	No	Yes	0	6	7
197	R:R:W318	R:R:W321	14.99	Yes	Yes	1	5	7
198	R:R:N323	R:R:N327	6.81	No	Yes	0	9	9
199	R:R:F333	R:R:I329	5.02	No	No	0	8	7
200	R:R:I330	R:R:Y331	3.63	No	Yes	0	8	9
201	R:R:A332	R:R:F337	5.55	No	Yes	0	6	9
202	R:R:F333	R:R:R338	4.28	No	No	0	8	8
203	R:R:F333	R:R:F341	4.29	No	No	0	8	7
204	R:R:D336	R:R:N334	4.04	No	No	0	7	8
205	R:R:A335	R:R:R338	4.15	No	No	0	5	8
206	R:R:A74	R:R:T37	3.36	No	No	0	7	7
207	R:R:L112	R:R:P206	3.28	No	Yes	0	5	9
208	R:R:C293	R:R:I196	3.27	No	No	0	6	6
209	R:R:S151	R:R:V152	3.23	No	No	0	8	4
210	R:R:F141	R:R:F61	3.22	No	No	0	3	4
211	R:R:R130	R:R:R133	3.2	No	No	0	5	4
212	R:R:A195	R:R:N292	3.13	No	Yes	0	5	6
213	R:R:I220	R:R:S126	3.1	No	No	0	6	7
214	R:R:I330	R:R:V276	3.07	No	No	0	8	7
215	R:R:K57	R:R:S56	3.06	No	No	0	5	8
216	R:R:M135	R:R:V58	3.04	No	No	0	7	6
217	R:R:L32	R:R:S36	3	No	No	0	4	4
218	R:R:L33	R:R:S325	3	No	No	0	7	6
219	R:R:L286	R:R:V282	2.98	No	No	0	6	7
220	R:R:N311	R:R:S310	2.98	No	No	0	1	1
221	R:R:I154	R:R:I201	2.94	No	No	0	5	4
222	R:R:I142	R:R:K138	2.91	No	No	0	1	4
223	R:R:W123	R:R:Y122	2.89	No	Yes	0	4	8
224	R:R:I290	R:R:L286	2.85	No	No	0	7	6
225	R:R:G93	R:R:W90	2.81	No	Yes	0	7	8
226	R:R:A47	R:R:F341	2.77	No	No	0	8	7
227	R:R:A340	R:R:F51	2.77	No	Yes	0	7	6
228	R:R:A140	R:R:F62	2.77	No	Yes	0	7	8
229	R:R:A87	R:R:F89	2.77	No	No	0	5	4
230	R:R:H164	R:R:V100	2.77	Yes	No	0	5	5
231	R:R:D187	R:R:K165	2.77	No	No	0	5	3
232	R:R:L344	R:R:L345	2.77	No	No	0	6	7
233	R:R:E267	R:R:I225	2.73	No	No	0	8	5
234	R:R:F20	R:R:S21	2.64	No	No	0	1	4
235	R:R:F337	R:R:V48	2.62	Yes	No	0	9	8
236	R:R:F337	R:R:V63	2.62	Yes	No	0	9	8
237	R:R:F319	R:R:V315	2.62	No	No	0	7	4
238	R:R:R23	R:R:T26	2.59	No	No	0	5	5
239	R:R:F51	R:R:T343	2.59	Yes	No	0	6	4
240	R:R:F29	R:R:L32	2.44	No	No	0	3	4
241	R:R:F341	R:R:L43	2.44	No	No	0	7	7
242	R:R:F51	R:R:R50	2.14	Yes	No	0	6	6
243	R:R:G40	R:R:P328	2.03	No	No	0	9	9
244	R:R:C298	R:R:G299	1.96	No	No	3	4	1
245	R:R:C307	R:R:G299	1.96	No	No	3	3	1
246	R:R:A67	R:R:C45	1.81	No	No	0	9	7
247	R:R:A340	R:R:A47	1.79	No	No	0	7	8
248	R:R:P128	R:R:S127	1.78	No	No	0	8	6
249	R:R:P328	R:R:V44	1.77	No	No	0	9	9
250	R:R:G279	R:R:M278	1.75	No	No	0	5	8
251	R:R:C28	R:R:S31	1.72	No	No	0	5	4
252	R:R:C45	R:R:V68	1.71	No	No	0	7	6
253	R:R:C284	R:R:V280	1.71	No	No	0	9	7
254	R:R:A147	R:R:V116	1.7	No	No	0	7	7
255	R:R:S126	R:R:S127	1.63	No	No	0	7	6
256	R:R:S197	R:R:S198	1.63	No	Yes	0	4	7
257	R:R:S145	R:R:V146	1.62	No	No	0	4	3
258	R:R:T26	R:R:V22	1.59	No	No	0	5	4
259	R:R:C28	R:R:L25	1.59	No	No	0	5	4
260	R:R:A322	R:R:L33	1.58	No	No	0	4	7
261	R:R:I142	R:R:V146	1.54	No	No	0	1	3
262	R:R:I211	R:R:V207	1.54	No	No	0	6	7
263	R:R:I225	R:R:V270	1.54	No	No	0	5	8
264	R:R:K165	R:R:S189	1.53	No	No	0	3	4
265	R:R:K272	R:R:V276	1.52	No	No	0	7	7
266	R:R:I277	R:R:T273	1.52	Yes	No	0	8	9
267	R:R:F319	R:R:G320	1.51	No	No	0	7	7
268	R:R:K138	R:R:T136	1.5	No	No	0	4	8
269	R:R:L38	R:R:V75	1.49	No	No	0	7	5
270	R:R:L72	R:R:V75	1.49	No	No	0	7	5
271	R:R:L76	R:R:V75	1.49	No	No	0	6	5
272	R:R:L326	R:R:V280	1.49	No	No	0	6	7
273	R:R:L71	R:R:T42	1.47	No	No	0	8	5
274	R:R:F61	R:R:P137	1.44	No	No	0	4	1
275	R:R:I86	R:R:L30	1.43	No	No	0	5	7
276	R:R:I201	R:R:L150	1.43	No	No	0	4	4
277	R:R:I157	R:R:L153	1.43	No	No	0	6	4
278	R:R:A140	R:R:F61	1.39	No	No	0	7	4
279	R:R:A229	R:R:R266	1.38	No	Yes	0	4	6
280	R:R:P158	R:R:W163	1.35	No	No	0	6	6
281	R:R:S191	R:R:Y194	1.27	No	Yes	0	5	7
282	R:R:I86	R:R:R23	1.25	No	No	0	5	5
283	R:R:K134	R:R:R130	1.24	No	No	0	5	5
284	R:R:K223	R:R:R226	1.24	No	No	0	5	5
285	R:R:N185	R:R:W90	1.13	No	Yes	0	4	8
286	R:R:E132	R:R:Y131	1.12	No	Yes	0	5	7
287	R:R:R219	R:R:Y218	1.03	No	Yes	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.84556	9	1	0
2	R:R:F51	3.0075	4	0	6
3	R:R:F62	5.20667	6	0	8
4	R:R:L66	5.646	5	1	9
5	R:R:D70	6.108	5	1	9
6	R:R:V77	4.765	4	1	8
7	R:R:M78	6.465	4	1	7
8	R:R:W90	5.96125	8	1	8
9	R:R:F92	8.74	5	1	6
10	R:R:F95	5.585	4	1	5
11	R:R:W99	6.024	5	1	5
12	R:R:D103	6.7	4	1	7
13	R:R:I111	6.2925	4	0	8
14	R:R:L114	5.53	4	1	9
15	R:R:R121	4.7075	4	1	9
16	R:R:Y122	8.784	5	0	8
17	R:R:Y131	5.56	4	0	7
18	R:R:W148	5.204	5	2	9
19	R:R:F156	4.925	4	0	5
20	R:R:H164	5.515	4	0	5
21	R:R:Y194	6.01833	6	0	7
22	R:R:S198	6.17	4	0	7
23	R:R:F203	9.335	6	1	8
24	R:R:Y204	6.065	4	1	5
25	R:R:P206	3.9275	4	0	9
26	R:R:Y214	4.856	5	1	9
27	R:R:Y218	3.2575	4	0	7
28	R:R:R266	4.595	4	0	6
29	R:R:I277	3.4375	4	1	8
30	R:R:F281	5.62	4	1	9
31	R:R:W285	6.54143	7	1	8
32	R:R:F288	7.176	5	1	7
33	R:R:F289	8.668	5	1	7
34	R:R:N292	5.485	4	1	6
35	R:R:F313	4.72	4	0	4
36	R:R:W318	8.585	4	1	5
37	R:R:W321	7.04143	7	1	7
38	R:R:N327	8.5275	4	1	9
39	R:R:Y331	4.44167	6	1	9
40	R:R:F337	4.344	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	33.3802	10.96	Yes	Yes	1	0	7
2	R:R:D103	R:R:W321	27.3242	5.58	Yes	Yes	1	7	7
3	R:R:W318	R:R:W321	18.9265	14.99	Yes	Yes	1	5	7
4	R:R:L30	R:R:W318	15.8447	6.83	No	Yes	0	7	5
5	R:R:I86	R:R:L30	12.3882	1.43	No	No	0	5	7
6	R:R:M78	R:R:W321	17.6666	8.14	Yes	Yes	1	7	7
7	R:R:M78	R:R:T37	13.4092	7.53	Yes	No	0	7	7
8	R:R:S325	R:R:T37	10.1119	6.4	No	No	0	6	7
9	R:R:V73	R:R:W321	63.4584	3.68	No	Yes	0	8	7
10	R:R:S324	R:R:V73	78.6614	9.7	No	No	0	9	8
11	R:R:D70	R:R:S324	79.0127	4.42	Yes	No	0	9	9
12	R:R:D70	R:R:N41	100	8.08	Yes	No	0	9	9
13	R:R:L71	R:R:N41	16.5379	4.12	No	No	0	8	9
14	R:R:L38	R:R:L71	12.6317	4.15	No	No	0	7	8
15	L:L:?1	R:R:S107	19.6431	6.74	Yes	No	1	0	7
16	R:R:S107	R:R:W285	28.8792	3.71	No	Yes	1	7	8
17	R:R:N323	R:R:W285	77.795	9.04	No	Yes	0	9	8
18	R:R:N323	R:R:N327	76.3524	6.81	No	Yes	0	9	9
19	R:R:D70	R:R:N327	46.1946	8.08	Yes	Yes	1	9	9
20	L:L:?1	R:R:F288	23.3198	13.11	Yes	Yes	1	0	7
21	R:R:F288	R:R:W285	47.4826	4.01	Yes	Yes	1	7	8
22	L:L:?1	R:R:F289	58.4984	7.65	Yes	Yes	1	0	7
23	R:R:F289	R:R:W285	21.2028	6.01	Yes	Yes	1	7	8
24	R:R:N41	R:R:P328	89.8272	9.77	No	No	0	9	9
25	R:R:G40	R:R:P328	77.6966	2.03	No	No	0	9	9
26	R:R:G40	R:R:L39	75.2424	3.42	No	No	0	9	4
27	R:R:L39	R:R:L43	72.7788	4.15	No	No	0	4	7
28	R:R:P328	R:R:V44	10.8426	1.77	No	No	0	9	9
29	R:R:F341	R:R:L43	65.3318	2.44	No	No	0	7	7
30	R:R:A47	R:R:F341	52.7329	2.77	No	No	0	8	7
31	R:R:A340	R:R:A47	50.185	1.79	No	No	0	7	8
32	R:R:A340	R:R:F51	47.6277	2.77	No	Yes	0	7	6
33	R:R:F51	R:R:H53	39.8998	4.53	Yes	No	0	6	6
34	R:R:H53	R:R:L54	34.701	5.14	No	No	0	6	9
35	R:R:F337	R:R:L54	26.8325	7.31	Yes	No	0	9	9
36	R:R:F337	R:R:V48	10.8426	2.62	Yes	No	0	9	8
37	R:R:L66	R:R:N327	26.7903	10.98	Yes	Yes	1	9	9
38	R:R:L66	R:R:N113	60.5873	4.12	Yes	No	0	9	8
39	R:R:N113	R:R:S65	58.5546	10.43	No	No	0	8	9
40	R:R:I144	R:R:S65	47.8807	6.19	No	No	0	8	9
41	R:R:F62	R:R:I144	45.9932	3.77	Yes	No	0	8	8
42	R:R:D120	R:R:F62	10.318	9.55	No	Yes	0	9	8
43	R:R:F203	R:R:F289	40.3213	18.22	Yes	Yes	1	8	7
44	R:R:F203	R:R:F281	52.7469	8.57	Yes	Yes	1	8	9
45	R:R:F281	R:R:L114	69.1958	3.65	Yes	Yes	1	9	9
46	R:R:L114	R:R:L66	13.6668	5.54	Yes	Yes	1	9	9
47	R:R:F62	R:R:M135	10.318	3.73	Yes	No	0	8	7
48	R:R:S65	R:R:W148	14.8799	4.94	No	Yes	0	9	9
49	R:R:L114	R:R:Y331	59.8614	4.69	Yes	Yes	1	9	9
50	R:R:D103	R:R:V77	12.1212	5.84	Yes	Yes	1	7	8
51	R:R:C106	R:R:V77	15.5075	3.42	No	Yes	0	7	8
52	L:L:?1	R:R:I104	37.9326	12.81	Yes	No	0	0	6
53	R:R:I104	R:R:Y194	35.6658	7.25	No	Yes	0	6	7
54	R:R:H164	R:R:Y194	56.6671	4.36	Yes	Yes	0	5	7
55	R:R:H164	R:R:V159	24.856	9.69	Yes	No	0	5	5
56	R:R:A101	R:R:V159	18.7111	5.09	No	No	0	6	5
57	R:R:A101	R:R:F156	16.6034	5.55	No	Yes	0	6	5
58	R:R:F102	R:R:F156	13.1938	5.36	No	Yes	0	5	5
59	L:L:?1	R:R:L190	37.9233	3.73	Yes	No	1	0	4
60	R:R:L190	R:R:Y194	42.2322	5.86	No	Yes	0	4	7
61	L:L:?1	R:R:S198	47.5247	10.78	Yes	Yes	0	0	7
62	R:R:S198	R:R:Y194	36.1903	7.63	Yes	Yes	0	7	7
63	R:R:F102	R:R:L76	12.51	14.61	No	No	0	5	6
64	R:R:V77	R:R:W99	41.5859	4.9	Yes	Yes	1	8	5
65	R:R:W90	R:R:W99	36.2419	5.62	Yes	Yes	1	8	5
66	R:R:K81	R:R:W321	20.9171	4.64	No	Yes	0	6	7
67	R:R:H164	R:R:V100	12.154	2.77	Yes	No	0	5	5
68	R:R:I111	R:R:W285	18.6174	10.57	Yes	Yes	0	8	8
69	R:R:I111	R:R:P206	16.2709	3.39	Yes	Yes	0	8	9
70	R:R:R121	R:R:Y331	63.894	5.14	Yes	Yes	1	9	9
71	R:R:R121	R:R:Y214	62.5544	6.17	Yes	Yes	1	9	9
72	R:R:S118	R:R:Y214	59.2338	3.82	No	Yes	0	8	9
73	R:R:I277	R:R:Y331	67.2521	3.63	Yes	Yes	1	8	9
74	R:R:I277	R:R:Y214	62.901	4.84	Yes	Yes	1	8	9
75	R:R:S118	R:R:T213	52.405	6.4	No	No	0	8	7
76	R:R:T213	R:R:Y122	48.9766	7.49	No	Yes	0	7	8
77	R:R:S126	R:R:Y122	28.2095	16.53	No	Yes	0	7	8
78	R:R:S126	R:R:S127	17.6994	1.63	No	No	0	7	6
79	R:R:R130	R:R:S127	10.6459	5.27	No	No	0	5	6
80	R:R:A140	R:R:F62	18.5846	2.77	No	Yes	0	7	8
81	R:R:A140	R:R:F61	16.5566	1.39	No	No	0	7	4
82	R:R:F61	R:R:P137	12.4725	1.44	No	No	0	4	1
83	R:R:P137	R:R:T136	10.4164	3.5	No	No	0	1	8
84	R:R:P158	R:R:Y194	37.113	9.74	No	Yes	0	6	7
85	R:R:I157	R:R:P158	14.8705	3.39	No	No	0	6	6
86	R:R:P158	R:R:W163	14.8705	1.35	No	No	0	6	6
87	R:R:H164	R:R:K165	18.2193	5.24	Yes	No	0	5	3
88	R:R:S191	R:R:Y194	14.8705	1.27	No	Yes	0	5	7
89	R:R:F203	R:R:Y204	10.4304	11.35	Yes	Yes	1	8	5
90	R:R:L274	R:R:Y214	59.2338	5.86	No	Yes	0	8	9
91	R:R:L274	R:R:Y218	55.8241	3.52	No	Yes	0	8	7
92	R:R:V270	R:R:Y218	42.0917	3.79	No	Yes	0	8	7
93	R:R:I225	R:R:V270	35.1693	1.54	No	No	0	5	8
94	R:R:E267	R:R:I225	17.6994	2.73	No	No	0	8	5
95	R:R:E267	R:R:Q222	10.6459	6.37	No	No	0	8	6
96	R:R:I225	R:R:R266	14.1773	6.26	No	Yes	0	5	6
97	R:R:G320	R:R:W285	10.7864	8.44	No	Yes	0	7	8
98	R:R:F288	R:R:F313	25.24	6.43	Yes	Yes	0	7	4
99	R:R:F313	R:R:L291	17.957	3.65	Yes	No	0	4	5
100	R:R:F333	R:R:F341	10.8426	4.29	No	No	0	8	7
101	R:R:L38	R:R:V75	11.3063	1.49	No	No	0	7	5
102	R:R:L76	R:R:V75	14.1118	1.49	No	No	0	6	5
103	R:R:D70	R:R:L66	78.3102	4.07	Yes	Yes	1	9	9
104	R:R:F203	R:R:W285	12.3273	4.01	Yes	Yes	1	8	8
105	R:R:F281	R:R:I111	15.4794	5.02	Yes	Yes	0	9	8
106	R:R:L114	R:R:N327	13.9197	8.24	Yes	Yes	1	9	9
107	R:R:L66	R:R:Y331	78.5209	3.52	Yes	Yes	1	9	9
108	R:R:F288	R:R:N292	11.9011	4.83	Yes	Yes	1	7	6
109	R:R:C106	R:R:V73	15.6573	3.42	No	No	0	7	8
110	R:R:V77	R:R:W321	17.6292	4.9	Yes	Yes	1	8	7
111	R:R:K81	R:R:W99	17.6432	6.96	No	Yes	0	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D103	10.96	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:I104	12.81	1	Yes	No	0	6	0	1
L:L:?1	R:R:S107	6.74	1	Yes	No	0	7	0	1
L:L:?1	R:R:T108	3.97	1	Yes	No	0	6	0	1
L:L:?1	R:R:L190	3.73	1	Yes	No	0	4	0	1
L:L:?1	R:R:S198	10.78	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F288	13.11	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F289	7.65	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N292	9.86	1	Yes	Yes	0	6	0	1
R:R:D103	R:R:V77	5.84	1	Yes	Yes	7	8	1	2
R:R:V77	R:R:W321	4.9	1	Yes	Yes	8	7	2	2
R:R:D103	R:R:S107	4.42	1	Yes	No	7	7	1	1
R:R:D103	R:R:W321	5.58	1	Yes	Yes	7	7	1	2
R:R:I104	R:R:Y194	7.25	0	No	Yes	6	7	1	2
R:R:S107	R:R:W285	3.71	1	No	Yes	7	8	1	2
R:R:S202	R:R:T108	9.59	0	No	No	6	6	2	1
R:R:I154	R:R:S198	4.64	0	No	Yes	5	7	2	1
R:R:L190	R:R:Y194	5.86	1	No	Yes	4	7	1	2
R:R:L190	R:R:N292	4.12	1	No	Yes	4	6	1	1
R:R:S198	R:R:Y194	7.63	0	Yes	Yes	7	7	1	2
R:R:F289	R:R:S199	3.96	1	Yes	No	7	7	1	2
R:R:F203	R:R:W285	4.01	1	Yes	Yes	8	8	2	2
R:R:F203	R:R:F289	18.22	1	Yes	Yes	8	7	2	1
R:R:F288	R:R:W285	4.01	1	Yes	Yes	7	8	1	2
R:R:F289	R:R:W285	6.01	1	Yes	Yes	7	8	1	2
R:R:F288	R:R:F289	7.5	1	Yes	Yes	7	7	1	1
R:R:F288	R:R:N292	4.83	1	Yes	Yes	7	6	1	1
R:R:F288	R:R:F313	6.43	1	Yes	Yes	7	4	1	2
R:R:A195	R:R:N292	3.13	0	No	Yes	5	6	2	1
R:R:S197	R:R:S198	1.63	0	No	Yes	4	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F1O_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	253
Number of Links	287
Number of Hubs	40
Number of Links mediated by Hubs	149
Number of Communities	3
Number of Nodes involved in Communities	40
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	112
Number Of Links MetaPath	111
Number of Shortest Paths	78291
Length Of Smallest Path	3
Average Path Length	13.4275
Length of Longest Path	29
Minimum Path Strength	1.34
Average Path Strength	5.82182
Maximum Path Strength	14.955
Minimum Path Correlation	0.73
Average Path Correlation	0.979561
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	15.3846
Average % Of Corr. Nodes	90.5887
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.8711
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	LDP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	LDP
Name	Dopamine
Synonyms	4-(2-Aminoethyl)benzene-1,2-diol
Identifier
Formula	C8 H11 N O2
Molecular Weight	153.178
SMILES
PubChem	681
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	0
Total Bonds	22
Total Aromatic Bonds	6


Code	MG
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	MG
Name	MAGNESIUM ION
Synonyms
Identifier
Formula	Mg
Molecular Weight	24.305
SMILES
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


Code	GDP
PDB Residues	O:O:?1
Environment Details	Open EMBL-EBI Page
Code	GDP
Name	Guanosine-5'-Diphosphate
Synonyms	Guanosine-5'-Diphosphate
Identifier
Formula	C10 H15 N5 O11 P2
Molecular Weight	443.201
SMILES
PubChem	8977
Formal Charge	0
Total Atoms	43
Total Chiral Atoms	4
Total Bonds	45
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21728
Sequence	>7F1O_nogp_Chain_R F S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F R H L R S K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G F W P F G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S P F R Y E R K M T P K A A F I L I S V A W T L S V L I S F I P V Q L S W H K A N C D S S L S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C G F C I D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F R K A F S T L L G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9JF4	A	Peptide	Bombesin	BB₁	Homo sapiens	PD168368	-	-	3.6	2025-07-09	To be published
	7W41	A	Peptide	Bombesin	BB₂	Homo sapiens	PD176252	-	-	2.95	2023-02-22	doi.org/10.1073/pnas.2216230120
	7CKZ	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7LJC	A	Amine	Dopamine	D₁	Homo sapiens	SKF-81297	Mevidalen	Gs/β1/γ2	3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJC (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF-81297	Mevidalen		3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ1	3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7X2F	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2F (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7F1O	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg	Gs/β1/γ2	3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1O (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg		3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7X2C	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam	Gs/β1/γ2	3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7X2C (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam		3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7JV5	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JV5 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7CKW	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKW (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-		3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-	Gs/β1/γ2	3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-		3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-	Gs/β1/γ2	3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-		3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	8IRR	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-	Gs/β1/γ2	3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8IRR (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-		3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	7JOZ	A	Amine	Dopamine	D₁	Homo sapiens	VFP	-	Gs/β1/γ2	3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7JOZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	VFP	-		3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7X2D	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-	Gs/β1/γ2	3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2D (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-		3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7F0T	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-	Gs/β1/γ2	3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F0T (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-		3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	8JXR	A	Amine	Dopamine	D₁	Homo sapiens	LSD	-	-	3.57	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8JXS	A	Amine	Dopamine	D₁	Homo sapiens	PF-6142	-	-	3	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	7CMV	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-	Gi1/β1/γ2	2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7CMV (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-		2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	8JD1	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	-	-	3.7	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	4NTJ	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	AZD1283	-	-	2.62	2014-03-26	doi.org/10.1038/nature13083
	7AD3	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	Gi1/STE4/γ2	3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7AD3 (No Gprot)	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-		3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7QA8	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	Peptide	-	-	2.7	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QB9	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	-	-	-	3.1	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBC	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.53	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBI	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.46	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	9V0U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9V0U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9I52	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-	Gs/β1/γ2	2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I52 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-		2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54	A	Amine	Dopamine	D₁	Homo sapiens	A1IZV	-	Gs/β1/γ2	2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A1IZV	-		2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

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