psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:V100	3.94	Yes	No	1	0	5
2	L:L:?1	R:R:D103	7.18	Yes	No	1	0	7
3	L:L:?1	R:R:I104	11.32	Yes	Yes	1	0	6
4	L:L:?1	R:R:S107	9.26	Yes	No	0	0	7
5	L:L:?1	R:R:L190	4.88	Yes	No	0	0	4
6	L:L:?1	R:R:S198	6.62	Yes	No	0	0	7
7	L:L:?1	R:R:S202	3.97	Yes	No	0	0	6
8	L:L:?1	R:R:F288	13.96	Yes	Yes	1	0	7
9	L:L:?1	R:R:F289	9.66	Yes	Yes	1	0	7
10	L:L:?1	R:R:N292	3.63	Yes	No	0	0	6
11	R:R:L25	R:R:S21	3	No	No	0	4	4
12	R:R:L30	R:R:W318	3.42	No	Yes	0	7	5
13	R:R:L35	R:R:S31	3	No	No	0	5	4
14	R:R:L33	R:R:T37	2.95	No	Yes	0	7	7
15	R:R:I34	R:R:M78	5.83	No	Yes	0	6	7
16	R:R:S325	R:R:S36	3.26	No	No	0	6	4
17	R:R:N41	R:R:T37	4.39	Yes	Yes	0	9	7
18	R:R:A74	R:R:T37	3.36	No	Yes	0	7	7
19	R:R:S325	R:R:T37	9.59	No	Yes	0	6	7
20	R:R:L38	R:R:V75	2.98	No	No	0	7	5
21	R:R:G40	R:R:L43	3.42	No	No	0	9	7
22	R:R:D70	R:R:N41	13.46	Yes	Yes	0	9	9
23	R:R:L71	R:R:N41	2.75	No	Yes	0	8	9
24	R:R:N41	R:R:P328	4.89	Yes	No	0	9	9
25	R:R:F341	R:R:L43	3.65	No	No	0	7	7
26	R:R:F341	R:R:V44	5.24	No	Yes	0	7	9
27	R:R:A47	R:R:F51	2.77	No	Yes	0	8	6
28	R:R:I64	R:R:V48	6.14	No	No	0	6	8
29	R:R:A340	R:R:F51	8.32	No	Yes	0	7	6
30	R:R:R52	R:R:R55	6.4	No	No	0	7	8
31	R:R:R52	R:R:S56	5.27	No	No	0	7	8
32	R:R:D336	R:R:L54	5.43	No	No	0	7	9
33	R:R:F337	R:R:L54	4.87	No	No	0	9	9
34	R:R:K57	R:R:T59	9.01	No	No	2	5	8
35	R:R:K57	R:R:N60	9.79	No	No	2	5	9
36	R:R:F61	R:R:V58	10.49	Yes	No	0	4	6
37	R:R:N60	R:R:T59	2.92	No	No	2	9	8
38	R:R:T59	R:R:Y131	4.99	No	Yes	0	8	7
39	R:R:N60	R:R:V63	5.91	No	No	0	9	8
40	R:R:A140	R:R:F61	2.77	No	Yes	0	7	4
41	R:R:F141	R:R:F61	8.57	No	Yes	0	3	4
42	R:R:F62	R:R:V116	5.24	Yes	No	0	8	7
43	R:R:D120	R:R:F62	11.94	No	Yes	0	9	8
44	R:R:A140	R:R:F62	2.77	No	Yes	0	7	8
45	R:R:F62	R:R:L143	3.65	Yes	No	0	8	7
46	R:R:F62	R:R:I144	5.02	Yes	No	0	8	8
47	R:R:N113	R:R:S65	7.45	No	No	0	8	9
48	R:R:I144	R:R:S65	3.1	No	No	0	8	9
49	R:R:D70	R:R:L66	4.07	Yes	Yes	1	9	9
50	R:R:L66	R:R:N113	2.75	Yes	No	0	9	8
51	R:R:L114	R:R:L66	5.54	No	Yes	1	9	9
52	R:R:L66	R:R:N327	8.24	Yes	No	1	9	9
53	R:R:L66	R:R:Y331	3.52	Yes	Yes	1	9	9
54	R:R:A109	R:R:S69	3.42	No	No	0	7	8
55	R:R:D70	R:R:S324	4.42	Yes	No	0	9	9
56	R:R:D70	R:R:N327	8.08	Yes	No	1	9	9
57	R:R:V73	R:R:V77	3.21	No	Yes	0	8	8
58	R:R:M78	R:R:V73	3.04	Yes	No	0	7	8
59	R:R:S324	R:R:V73	6.46	No	No	0	9	8
60	R:R:F102	R:R:L76	7.31	No	No	0	5	6
61	R:R:D103	R:R:V77	7.3	No	Yes	1	7	8
62	R:R:C106	R:R:V77	3.42	No	Yes	0	7	8
63	R:R:V77	R:R:W321	3.68	Yes	Yes	1	8	7
64	R:R:M78	R:R:P79	3.35	Yes	No	0	7	8
65	R:R:M78	R:R:W318	3.49	Yes	Yes	1	7	5
66	R:R:M78	R:R:W321	5.82	Yes	Yes	1	7	7
67	R:R:F92	R:R:W80	4.01	Yes	No	0	6	5
68	R:R:W80	R:R:W99	7.5	No	No	0	5	5
69	R:R:E85	R:R:K81	4.05	No	Yes	1	4	6
70	R:R:D314	R:R:K81	8.3	Yes	Yes	1	4	6
71	R:R:K81	R:R:W318	11.6	Yes	Yes	1	6	5
72	R:R:K81	R:R:W321	4.64	Yes	Yes	1	6	7
73	R:R:D314	R:R:E85	5.2	Yes	No	1	4	4
74	R:R:F92	R:R:W90	7.02	Yes	Yes	0	6	8
75	R:R:C186	R:R:W90	10.45	No	Yes	0	9	8
76	R:R:F92	R:R:F95	10.72	Yes	No	0	6	5
77	R:R:N97	R:R:S94	2.98	No	No	0	6	1
78	R:R:F95	R:R:I98	6.28	No	No	0	5	6
79	R:R:C186	R:R:C96	7.28	No	No	0	9	9
80	R:R:I98	R:R:N97	4.25	No	No	0	6	6
81	R:R:F102	R:R:I98	5.02	No	No	0	5	6
82	R:R:W321	R:R:W99	4.69	Yes	No	0	7	5
83	R:R:I104	R:R:V100	3.07	Yes	No	1	6	5
84	R:R:S162	R:R:V100	3.23	No	No	0	5	5
85	R:R:A101	R:R:F156	2.77	No	No	0	6	5
86	R:R:F102	R:R:F156	5.36	No	No	0	5	5
87	R:R:D103	R:R:W321	15.63	No	Yes	1	7	7
88	R:R:I104	R:R:S155	3.1	Yes	No	0	6	7
89	R:R:I104	R:R:Y194	6.04	Yes	Yes	0	6	7
90	R:R:M105	R:R:S151	3.07	No	No	0	5	8
91	R:R:M105	R:R:S155	4.6	No	No	0	5	7
92	R:R:I111	R:R:T108	3.04	Yes	Yes	1	8	6
93	R:R:L112	R:R:T108	2.95	Yes	Yes	1	5	6
94	R:R:S151	R:R:T108	3.2	No	Yes	0	8	6
95	R:R:S202	R:R:T108	6.4	No	Yes	0	6	6
96	R:R:I111	R:R:L112	2.85	Yes	Yes	1	8	5
97	R:R:F281	R:R:I111	3.77	Yes	Yes	1	9	8
98	R:R:I111	R:R:W285	3.52	Yes	Yes	1	8	8
99	R:R:A147	R:R:L112	3.15	No	Yes	0	7	5
100	R:R:L112	R:R:L150	2.77	Yes	No	0	5	4
101	R:R:L112	R:R:P206	3.28	Yes	No	0	5	9
102	R:R:F281	R:R:L114	3.65	Yes	No	1	9	9
103	R:R:L114	R:R:Y331	3.52	No	Yes	1	9	9
104	R:R:I117	R:R:Y331	8.46	No	Yes	0	9	9
105	R:R:M210	R:R:S118	7.67	Yes	No	1	8	8
106	R:R:S118	R:R:Y214	11.45	No	Yes	1	8	9
107	R:R:V119	R:R:W123	9.81	No	No	0	6	4
108	R:R:D120	R:R:Y131	10.34	No	Yes	0	9	7
109	R:R:R121	R:R:Y331	9.26	No	Yes	0	9	9
110	R:R:S126	R:R:Y122	6.36	No	Yes	0	7	8
111	R:R:T213	R:R:Y122	7.49	No	Yes	0	7	8
112	R:R:R216	R:R:Y122	8.23	No	Yes	0	5	8
113	R:R:I217	R:R:Y122	4.84	No	Yes	0	9	8
114	R:R:A124	R:R:Y131	9.34	No	Yes	0	8	7
115	R:R:I125	R:R:I217	4.42	No	No	0	8	9
116	R:R:S126	R:R:S127	3.26	No	No	0	7	6
117	R:R:R130	R:R:S127	3.95	No	No	0	5	6
118	R:R:R130	R:R:R133	6.4	No	No	3	5	4
119	R:R:K134	R:R:R130	4.95	No	No	3	5	5
120	R:R:M135	R:R:Y131	8.38	No	Yes	0	7	7
121	R:R:K134	R:R:R133	8.66	No	No	3	5	4
122	R:R:P137	R:R:T136	3.5	No	No	4	1	8
123	R:R:K138	R:R:T136	12.01	No	No	4	4	8
124	R:R:K138	R:R:P137	3.35	No	No	4	4	1
125	R:R:F141	R:R:I144	3.77	No	No	0	3	8
126	R:R:T149	R:R:V146	3.17	No	No	0	3	3
127	R:R:I154	R:R:S198	3.1	No	No	0	5	7
128	R:R:I154	R:R:I201	4.42	No	No	0	5	4
129	R:R:F156	R:R:S155	6.61	No	No	0	5	7
130	R:R:I157	R:R:V159	3.07	No	No	0	6	5
131	R:R:L161	R:R:V159	2.98	No	No	0	4	5
132	R:R:L161	R:R:Y194	4.69	No	Yes	0	4	7
133	R:R:H164	R:R:S191	5.58	No	No	0	5	5
134	R:R:C186	R:R:N185	3.15	No	No	0	9	4
135	R:R:P296	R:R:S189	7.13	No	No	0	5	4
136	R:R:L190	R:R:Y194	3.52	No	Yes	0	4	7
137	R:R:F289	R:R:S199	5.28	Yes	No	0	7	7
138	R:R:C293	R:R:S199	3.44	No	No	0	6	7
139	R:R:V200	R:R:Y204	7.57	No	No	0	4	5
140	R:R:F203	R:R:Y204	11.35	Yes	No	0	8	5
141	R:R:F203	R:R:V207	10.49	Yes	No	0	8	7
142	R:R:F203	R:R:L286	3.65	Yes	No	0	8	6
143	R:R:F203	R:R:F289	30.01	Yes	Yes	0	8	7
144	R:R:C293	R:R:Y204	5.38	No	No	0	6	5
145	R:R:I205	R:R:P206	3.39	No	No	0	5	9
146	R:R:I211	R:R:V207	3.07	No	No	0	6	7
147	R:R:F281	R:R:V207	5.24	Yes	No	0	9	7
148	R:R:M210	R:R:Y214	4.79	Yes	Yes	1	8	9
149	R:R:M210	R:R:M278	7.22	Yes	Yes	1	8	8
150	R:R:F281	R:R:M210	8.71	Yes	Yes	1	9	8
151	R:R:I211	R:R:M278	2.92	No	Yes	0	6	8
152	R:R:I277	R:R:Y214	8.46	No	Yes	0	8	9
153	R:R:R216	R:R:R219	6.4	No	No	0	5	4
154	R:R:I220	R:R:R216	3.76	No	No	0	6	5
155	R:R:Q222	R:R:Y218	5.64	No	Yes	0	6	7
156	R:R:E267	R:R:Y218	6.73	No	Yes	5	8	7
157	R:R:L271	R:R:Y218	9.38	No	Yes	5	7	7
158	R:R:L274	R:R:Y218	3.52	No	Yes	0	8	7
159	R:R:A230	R:R:R226	2.77	No	No	0	4	5
160	R:R:I228	R:R:R266	6.26	No	No	0	7	6
161	R:R:H237	R:R:R233	3.39	No	No	0	1	1
162	R:R:F264	R:R:S263	3.96	No	No	0	5	5
163	R:R:E267	R:R:L271	3.98	No	No	5	8	7
164	R:R:K272	R:R:V276	6.07	No	No	0	7	7
165	R:R:I277	R:R:I330	2.94	No	Yes	0	8	8
166	R:R:F281	R:R:M278	3.73	Yes	Yes	1	9	8
167	R:R:M278	R:R:V282	3.04	Yes	No	0	8	7
168	R:R:I330	R:R:V280	4.61	Yes	No	0	8	7
169	R:R:F281	R:R:W285	4.01	Yes	Yes	1	9	8
170	R:R:C284	R:R:N323	9.45	No	No	0	9	9
171	R:R:F288	R:R:W285	4.01	Yes	Yes	1	7	8
172	R:R:F289	R:R:W285	3.01	Yes	Yes	1	7	8
173	R:R:W285	R:R:W321	2.81	Yes	Yes	1	8	7
174	R:R:N323	R:R:W285	6.78	No	Yes	0	9	8
175	R:R:L286	R:R:P287	3.28	No	No	0	6	9
176	R:R:I290	R:R:L286	2.85	No	No	0	7	6
177	R:R:F288	R:R:F289	7.5	Yes	Yes	1	7	7
178	R:R:F288	R:R:V317	5.24	Yes	No	0	7	6
179	R:R:F306	R:R:L291	4.87	No	No	6	1	5
180	R:R:I308	R:R:L291	2.85	No	No	6	4	5
181	R:R:F313	R:R:L291	3.65	No	No	0	4	5
182	R:R:F313	R:R:N292	6.04	No	No	0	4	6
183	R:R:L295	R:R:P296	3.28	No	No	0	3	5
184	R:R:F313	R:R:L295	7.31	No	No	0	4	3
185	R:R:C298	R:R:C307	5.46	No	No	0	4	3
186	R:R:G301	R:R:S300	3.71	No	No	0	3	1
187	R:R:P305	R:R:T303	10.49	No	No	0	1	1
188	R:R:C307	R:R:T303	6.76	No	No	0	3	1
189	R:R:P305	R:R:Q304	3.16	No	No	0	1	4
190	R:R:F306	R:R:I308	5.02	No	No	6	1	4
191	R:R:I308	R:R:T312	4.56	No	No	0	4	4
192	R:R:F316	R:R:T312	3.89	No	No	0	5	4
193	R:R:D314	R:R:V317	2.92	Yes	No	0	4	6
194	R:R:D314	R:R:W318	3.35	Yes	Yes	1	4	5
195	R:R:V317	R:R:W321	8.58	No	Yes	0	6	7
196	R:R:W318	R:R:W321	6.56	Yes	Yes	1	5	7
197	R:R:N323	R:R:N327	4.09	No	No	0	9	9
198	R:R:F333	R:R:I329	8.79	No	No	0	8	7
199	R:R:A332	R:R:F337	2.77	No	No	0	6	9
200	R:R:F333	R:R:R338	20.31	No	No	0	8	8
201	R:R:D336	R:R:N334	5.39	No	No	0	7	8
202	R:R:F337	R:R:N334	4.83	No	No	0	9	8
203	R:R:K339	R:R:T343	3	No	No	0	5	4
204	R:R:F92	R:R:V83	2.62	Yes	No	0	6	4
205	R:R:A84	R:R:W90	2.59	No	Yes	0	5	8
206	R:R:A109	R:R:W148	2.59	No	Yes	0	7	9
207	R:R:V270	R:R:Y218	2.52	No	Yes	0	8	7
208	R:R:I49	R:R:R55	2.51	No	No	0	4	8
209	R:R:I225	R:R:R266	2.51	No	No	0	5	6
210	R:R:T213	R:R:Y214	2.5	No	Yes	0	7	9
211	R:R:H164	R:R:Q160	2.47	No	No	0	5	5
212	R:R:F29	R:R:L30	2.44	No	No	0	3	7
213	R:R:F51	R:R:L344	2.44	Yes	No	0	6	6
214	R:R:F341	R:R:L344	2.44	No	No	0	7	6
215	R:R:M105	R:R:W148	2.33	No	Yes	0	5	9
216	R:R:M135	R:R:W123	2.33	No	No	0	7	4
217	R:R:E132	R:R:F129	2.33	No	No	0	5	7
218	R:R:L72	R:R:W148	2.28	No	Yes	0	7	9
219	R:R:F51	R:R:R50	2.14	Yes	No	0	6	6
220	R:R:C115	R:R:P206	1.88	No	No	0	7	9
221	R:R:A332	R:R:P328	1.87	No	No	0	6	9
222	R:R:G299	R:R:S300	1.86	No	No	0	1	1
223	R:R:G279	R:R:V282	1.84	No	No	0	5	7
224	R:R:C283	R:R:C284	1.82	No	No	0	5	9
225	R:R:A67	R:R:C45	1.81	No	No	0	9	7
226	R:R:P128	R:R:S127	1.78	No	No	0	8	6
227	R:R:G40	R:R:L39	1.71	No	No	0	9	4
228	R:R:A67	R:R:V44	1.7	No	Yes	0	9	9
229	R:R:A332	R:R:V44	1.7	No	Yes	0	6	9
230	R:R:I157	R:R:P158	1.69	No	No	0	6	6
231	R:R:I294	R:R:P305	1.69	No	No	0	5	1
232	R:R:A139	R:R:T136	1.68	No	No	0	6	8
233	R:R:C28	R:R:I24	1.64	No	No	0	5	6
234	R:R:C115	R:R:I209	1.64	No	No	0	7	6
235	R:R:E302	R:R:G301	1.64	No	No	0	3	3
236	R:R:S110	R:R:S69	1.63	No	No	0	9	8
237	R:R:S151	R:R:V152	1.62	No	No	0	8	4
238	R:R:V44	R:R:V48	1.6	Yes	No	0	9	8
239	R:R:C284	R:R:L326	1.59	No	No	0	9	6
240	R:R:C298	R:R:L295	1.59	No	No	0	4	3
241	R:R:A82	R:R:L30	1.58	No	No	0	6	7
242	R:R:A322	R:R:L33	1.58	No	No	0	4	7
243	R:R:A74	R:R:L38	1.58	No	No	0	7	7
244	R:R:A195	R:R:L190	1.58	No	No	0	5	4
245	R:R:A335	R:R:N334	1.56	No	No	0	5	8
246	R:R:I196	R:R:S197	1.55	No	No	0	6	4
247	R:R:I49	R:R:V48	1.54	No	No	0	4	8
248	R:R:I330	R:R:V276	1.54	Yes	No	0	8	7
249	R:R:I211	R:R:T215	1.52	No	No	0	6	3
250	R:R:K239	R:R:V236	1.52	No	No	0	3	4
251	R:R:F319	R:R:G320	1.51	No	No	0	7	7
252	R:R:L143	R:R:V146	1.49	No	No	0	7	3
253	R:R:L39	R:R:T42	1.47	No	No	0	4	5
254	R:R:L71	R:R:T42	1.47	No	No	0	8	5
255	R:R:D187	R:R:S310	1.47	No	No	0	5	1
256	R:R:L274	R:R:T273	1.47	No	No	0	8	9
257	R:R:D309	R:R:S310	1.47	No	No	0	4	1
258	R:R:I329	R:R:I330	1.47	No	Yes	0	7	8
259	R:R:F61	R:R:P137	1.44	Yes	No	0	4	1
260	R:R:I24	R:R:L25	1.43	No	No	0	6	4
261	R:R:G88	R:R:W90	1.41	No	Yes	0	4	8
262	R:R:L150	R:R:L153	1.38	No	No	0	4	4
263	R:R:A230	R:R:R227	1.38	No	No	0	4	5
264	R:R:P91	R:R:W90	1.35	No	Yes	0	1	8
265	R:R:F51	R:R:T343	1.3	Yes	No	0	6	4
266	R:R:H53	R:R:L54	1.29	No	No	0	6	9
267	R:R:S191	R:R:Y194	1.27	No	Yes	0	5	7
268	R:R:V68	R:R:W148	1.23	No	Yes	0	6	9
269	L:L:?1	R:R:D187	1.2	Yes	No	0	0	5
270	R:R:L274	R:R:Y214	1.17	No	Yes	0	8	9
271	R:R:E232	R:R:R266	1.16	No	No	0	3	6
272	R:R:N97	R:R:W163	1.13	No	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.87454	11	1	0
2	R:R:T37	5.0725	4	0	7
3	R:R:N41	6.3725	4	0	9
4	R:R:V44	2.56	4	0	9
5	R:R:F51	3.394	5	0	6
6	R:R:F61	5.8175	4	0	4
7	R:R:F62	5.724	5	0	8
8	R:R:L66	4.824	5	1	9
9	R:R:D70	7.5075	4	1	9
10	R:R:V77	4.4025	4	1	8
11	R:R:M78	4.306	5	1	7
12	R:R:K81	7.1475	4	1	6
13	R:R:W90	4.564	5	0	8
14	R:R:F92	6.0925	4	0	6
15	R:R:I104	5.8825	4	1	6
16	R:R:T108	3.8975	4	1	6
17	R:R:I111	3.295	4	1	8
18	R:R:L112	3	5	1	5
19	R:R:Y122	6.73	4	0	8
20	R:R:Y131	8.2625	4	0	7
21	R:R:W148	2.1075	4	0	9
22	R:R:Y194	3.88	4	0	7
23	R:R:F203	13.875	4	0	8
24	R:R:M210	7.0975	4	1	8
25	R:R:Y214	5.674	5	1	9
26	R:R:Y218	5.558	5	5	7
27	R:R:M278	4.2275	4	1	8
28	R:R:F281	4.85167	6	1	9
29	R:R:W285	4.02333	6	1	8
30	R:R:F288	7.6775	4	1	7
31	R:R:F289	11.092	5	1	7
32	R:R:D314	4.9425	4	1	4
33	R:R:W318	5.684	5	1	5
34	R:R:W321	6.55125	8	1	7
35	R:R:I330	2.64	4	0	8
36	R:R:Y331	6.19	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	24.1439	7.18	Yes	No	1	0	7
2	R:R:D103	R:R:V77	16.6991	7.3	No	Yes	1	7	8
3	R:R:V73	R:R:V77	23.2862	3.21	No	Yes	0	8	8
4	R:R:S324	R:R:V73	33.2976	6.46	No	No	0	9	8
5	R:R:D70	R:R:S324	33.2574	4.42	Yes	No	0	9	9
6	R:R:D70	R:R:N41	100	13.46	Yes	Yes	0	9	9
7	R:R:N41	R:R:T37	21.2759	4.39	Yes	Yes	0	9	7
8	L:L:?1	R:R:F288	49.3735	13.96	Yes	Yes	1	0	7
9	R:R:F288	R:R:W285	50.9013	4.01	Yes	Yes	1	7	8
10	R:R:N323	R:R:W285	74.9648	6.78	No	Yes	0	9	8
11	R:R:N323	R:R:N327	71.3462	4.09	No	No	0	9	9
12	R:R:D70	R:R:N327	44.9977	8.08	Yes	No	1	9	9
13	L:L:?1	R:R:F289	53.1059	9.66	Yes	Yes	1	0	7
14	R:R:F289	R:R:W285	55.0627	3.01	Yes	Yes	1	7	8
15	R:R:L71	R:R:N41	12.8526	2.75	No	Yes	0	8	9
16	R:R:L71	R:R:T42	10.2593	1.47	No	No	0	8	5
17	R:R:N41	R:R:P328	67.8416	4.89	Yes	No	0	9	9
18	R:R:A332	R:R:P328	65.4962	1.87	No	No	0	6	9
19	R:R:A332	R:R:V44	46.358	1.7	No	Yes	0	6	9
20	R:R:F341	R:R:V44	23.9228	5.24	No	Yes	0	7	9
21	R:R:F341	R:R:L344	18.6625	2.44	No	No	0	7	6
22	R:R:F51	R:R:L344	16.0356	2.44	Yes	No	0	6	6
23	R:R:V44	R:R:V48	16.0356	1.6	Yes	No	0	9	8
24	R:R:I49	R:R:V48	10.7418	1.54	No	No	0	4	8
25	R:R:A332	R:R:F337	18.6625	2.77	No	No	0	6	9
26	R:R:F281	R:R:W285	64.0287	4.01	Yes	Yes	1	9	8
27	R:R:F281	R:R:L114	62.3869	3.65	Yes	No	1	9	9
28	R:R:L114	R:R:L66	57.1869	5.54	No	Yes	1	9	9
29	R:R:L66	R:R:N113	70.904	2.75	Yes	No	0	9	8
30	R:R:N113	R:R:S65	68.3442	7.45	No	No	0	8	9
31	R:R:I144	R:R:S65	65.771	3.1	No	No	0	8	9
32	R:R:F62	R:R:I144	44.0528	5.02	Yes	No	0	8	8
33	R:R:D120	R:R:F62	28.3388	11.94	No	Yes	0	9	8
34	R:R:D120	R:R:Y131	25.5646	10.34	No	Yes	0	9	7
35	R:R:T59	R:R:Y131	11.4923	4.99	No	Yes	0	8	7
36	R:R:L66	R:R:N327	25.7254	8.24	Yes	No	1	9	9
37	R:R:F141	R:R:I144	19.3259	3.77	No	No	0	3	8
38	R:R:F141	R:R:F61	16.5248	8.57	No	Yes	0	3	4
39	L:L:?1	R:R:I104	40.8229	11.32	Yes	Yes	1	0	6
40	R:R:I104	R:R:S155	18.7362	3.1	Yes	No	0	6	7
41	R:R:M105	R:R:W148	10.8624	2.33	No	Yes	0	5	9
42	R:R:F156	R:R:S155	16.4243	6.61	No	No	0	5	7
43	R:R:F102	R:R:F156	10.2057	5.36	No	No	0	5	5
44	R:R:W321	R:R:W99	32.6275	4.69	Yes	No	0	7	5
45	R:R:W80	R:R:W99	30.5569	7.5	No	No	0	5	5
46	R:R:F92	R:R:W80	28.4795	4.01	Yes	No	0	6	5
47	R:R:F92	R:R:W90	16.5047	7.02	Yes	Yes	0	6	8
48	R:R:F92	R:R:F95	10.7485	10.72	Yes	No	0	6	5
49	L:L:?1	R:R:L190	27.3068	4.88	Yes	No	0	0	4
50	R:R:L190	R:R:Y194	21.946	3.52	No	Yes	0	4	7
51	R:R:S151	R:R:T108	14.9702	3.2	No	Yes	0	8	6
52	R:R:I111	R:R:T108	16.0356	3.04	Yes	Yes	1	8	6
53	R:R:I111	R:R:W285	11.1774	3.52	Yes	Yes	1	8	8
54	R:R:F281	R:R:M210	53.0322	8.71	Yes	Yes	1	9	8
55	R:R:M210	R:R:Y214	50.7673	4.79	Yes	Yes	1	8	9
56	R:R:T213	R:R:Y214	24.2981	2.5	No	Yes	0	7	9
57	R:R:T213	R:R:Y122	22.5089	7.49	No	Yes	0	7	8
58	R:R:S126	R:R:Y122	11.4923	6.36	No	Yes	0	7	8
59	R:R:F61	R:R:P137	11.4923	1.44	Yes	No	0	4	1
60	R:R:I104	R:R:Y194	23.4805	6.04	Yes	Yes	0	6	7
61	R:R:L161	R:R:Y194	22.5893	4.69	No	Yes	0	4	7
62	R:R:L161	R:R:V159	16.9604	2.98	No	No	0	4	5
63	R:R:I157	R:R:V159	11.3181	3.07	No	No	0	6	5
64	R:R:S191	R:R:Y194	16.9604	1.27	No	Yes	0	5	7
65	R:R:H164	R:R:S191	11.3181	5.58	No	No	0	5	5
66	L:L:?1	R:R:N292	45.8822	3.63	Yes	No	0	0	6
67	R:R:F313	R:R:N292	43.1147	6.04	No	No	0	4	6
68	R:R:F313	R:R:L295	26.228	7.31	No	No	0	4	3
69	R:R:I277	R:R:Y214	15.2181	8.46	No	Yes	0	8	9
70	R:R:L274	R:R:Y214	13.2212	1.17	No	Yes	0	8	9
71	R:R:I277	R:R:I330	13.3619	2.94	No	Yes	0	8	8
72	R:R:F313	R:R:L291	14.7021	3.65	No	No	0	4	5
73	R:R:C298	R:R:L295	17.6037	1.59	No	No	0	4	3
74	R:R:C298	R:R:C307	14.7021	5.46	No	No	0	4	3
75	R:R:C307	R:R:T303	11.7872	6.76	No	No	0	3	1
76	R:R:M105	R:R:S151	11.8743	3.07	No	No	0	5	8
77	R:R:D70	R:R:L66	30.1883	4.07	Yes	Yes	1	9	9
78	R:R:W285	R:R:W321	32.3527	2.81	Yes	Yes	1	8	7
79	R:R:I111	R:R:L112	11.4588	2.85	Yes	Yes	1	8	5
80	R:R:F281	R:R:I111	17.8918	3.77	Yes	Yes	1	9	8
81	R:R:M78	R:R:V73	11.3047	3.04	Yes	No	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:V100	3.94	1	Yes	No	0	5	0	1
L:L:?1	R:R:D103	7.18	1	Yes	No	0	7	0	1
L:L:?1	R:R:I104	11.32	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S107	9.26	1	Yes	No	0	7	0	1
L:L:?1	R:R:L190	4.88	1	Yes	No	0	4	0	1
L:L:?1	R:R:S198	6.62	1	Yes	No	0	7	0	1
L:L:?1	R:R:S202	3.97	1	Yes	No	0	6	0	1
L:L:?1	R:R:F288	13.96	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F289	9.66	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N292	3.63	1	Yes	No	0	6	0	1
R:R:D103	R:R:V77	7.3	1	No	Yes	7	8	1	2
R:R:V77	R:R:W321	3.68	1	Yes	Yes	8	7	2	2
R:R:I104	R:R:V100	3.07	1	Yes	No	6	5	1	1
R:R:S162	R:R:V100	3.23	0	No	No	5	5	2	1
R:R:D103	R:R:W321	15.63	1	No	Yes	7	7	1	2
R:R:I104	R:R:S155	3.1	1	Yes	No	6	7	1	2
R:R:I104	R:R:Y194	6.04	1	Yes	Yes	6	7	1	2
R:R:S202	R:R:T108	6.4	0	No	Yes	6	6	1	2
R:R:I154	R:R:S198	3.1	0	No	No	5	7	2	1
R:R:L190	R:R:Y194	3.52	0	No	Yes	4	7	1	2
R:R:F289	R:R:S199	5.28	1	Yes	No	7	7	1	2
R:R:F203	R:R:F289	30.01	0	Yes	Yes	8	7	2	1
R:R:F288	R:R:W285	4.01	1	Yes	Yes	7	8	1	2
R:R:F289	R:R:W285	3.01	1	Yes	Yes	7	8	1	2
R:R:W285	R:R:W321	2.81	1	Yes	Yes	8	7	2	2
R:R:F288	R:R:F289	7.5	1	Yes	Yes	7	7	1	1
R:R:F288	R:R:V317	5.24	1	Yes	No	7	6	1	2
R:R:F313	R:R:N292	6.04	0	No	No	4	6	2	1
R:R:V317	R:R:W321	8.58	0	No	Yes	6	7	2	2
R:R:A195	R:R:L190	1.58	0	No	No	5	4	2	1
R:R:D187	R:R:S310	1.47	0	No	No	5	1	1	2
L:L:?1	R:R:D187	1.2	1	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7JOZ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.75
Number of Linked Nodes	249
Number of Links	272
Number of Hubs	36
Number of Links mediated by Hubs	137
Number of Communities	6
Number of Nodes involved in Communities	42
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	42356
Length Of Smallest Path	3
Average Path Length	11.8515
Length of Longest Path	23
Minimum Path Strength	1.32
Average Path Strength	5.39922
Maximum Path Strength	20.68
Minimum Path Correlation	0.7
Average Path Correlation	0.95029
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	7.69231
Average % Of Corr. Nodes	66.4139
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.4052
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • arrestin family protein binding • neurotransmitter receptor activity • dopamine neurotransmitter receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • dopamine neurotransmitter receptor activity, coupled via Gs • cation binding • ion binding • catecholamine binding • dopamine binding • small molecule binding • G-protein alpha-subunit binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • heterotrimeric G-protein binding • hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • response to xenobiotic stimulus • behavior • learning • learning or memory • feeding behavior • cognition • associative learning • conditioned taste aversion • D-glucose import • hexose transmembrane transport • transport • carbohydrate transport • establishment of localization • transmembrane transport • localization • D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • reproductive process • multicellular organismal reproductive process • reproductive behavior • mating behavior • nonassociative learning • habituation • memory • protein localization • establishment of protein localization • cellular localization • nitrogen compound transport • nucleocytoplasmic transport • nuclear transport • intracellular transport • protein localization to nucleus • import into nucleus • establishment of protein localization to organelle • protein transport • cellular macromolecule localization • macromolecule localization • protein localization to organelle • establishment of localization in cell • protein import into nucleus • intracellular protein transport • cellular developmental process • forebrain development • central nervous system neuron development • cell development • substrate-independent telencephalic tangential migration • cerebral cortex GABAergic interneuron differentiation • interneuron migration • neurogenesis • central nervous system neuron differentiation • telencephalon cell migration • forebrain cell migration • neuron differentiation • cell differentiation • substrate-independent telencephalic tangential interneuron migration • cerebral cortex GABAergic interneuron migration • cell migration • cell motility • GABAergic neuron differentiation • head development • interneuron migration from the subpallium to the cortex • neuron migration • forebrain generation of neurons • brain development • nervous system development • cerebral cortex GABAergic interneuron development • generation of neurons • forebrain neuron development • central nervous system development • neuron development • telencephalon development • cerebral cortex neuron differentiation • forebrain neuron differentiation • astrocyte differentiation • glial cell development • astrocyte development • gliogenesis • glial cell differentiation • startle response • regulation of response to external stimulus • neuromuscular process • negative regulation of response to stimulus • negative regulation of biological process • prepulse inhibition • response to external stimulus • regulation of response to stimulus • negative regulation of response to external stimulus • regulation of localization • regulation of potassium ion transport • regulation of transport • regulation of monoatomic ion transport • positive regulation of biological process • metal ion transport • positive regulation of potassium ion transport • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • potassium ion transport • monoatomic cation transport • regulation of metal ion transport • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • transmission of nerve impulse • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • striatum development • subpallium development • adult walking behavior • adult locomotory behavior • adult behavior • locomotory behavior • walking behavior • cellular component organization • cellular component biogenesis • cell junction organization • cellular component assembly • cell junction assembly • synapse organization • cellular component organization or biogenesis • synapse assembly • phospholipase C-activating dopamine receptor signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • peristalsis • muscle system process • modification of postsynaptic structure • modification of synaptic structure • behavioral response to cocaine • response to cocaine • response to alkaloid • positive regulation of cell communication • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • positive regulation of cellular process • positive regulation of synaptic transmission • positive regulation of synaptic transmission, glutamatergic • positive regulation of signaling • maternal behavior • parental behavior • sensitization • positive regulation of locomotion • regulation of cell motility • regulation of neuron migration • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • locomotion • regulation of locomotion • positive regulation of neuron migration • monoamine transport • import into cell • regulation of catecholamine uptake involved in synaptic transmission • organic hydroxy compound transport • catecholamine uptake • dopamine transport • dopamine uptake involved in synaptic transmission • catecholamine transport • regulation of dopamine uptake involved in synaptic transmission • neurotransmitter reuptake • regulation of neurotransmitter uptake • catecholamine uptake involved in synaptic transmission • regulation of neurotransmitter transport • neurotransmitter transport • amine transport • neurotransmitter uptake • regulation of amine transport • synaptic transmission, dopaminergic • dopamine uptake • response to light stimulus • visual learning • visual behavior • response to radiation • response to abiotic stimulus • action potential • neuronal action potential • regulation of biological quality • regulation of membrane potential • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • dentate gyrus development • pallium development • hippocampus development • limbic system development • multicellular organismal-level homeostasis • homeostatic process • temperature homeostasis • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • inorganic ion transmembrane transport • inorganic cation transmembrane transport • maintenance of location • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • inorganic ion homeostasis • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • negative regulation of cellular process • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • cellular homeostasis • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • response to amine • response to amphetamine • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • negative regulation of signaling • negative regulation of synaptic transmission • negative regulation of cell communication • regulation of synaptic plasticity • long-term synaptic depression • operant conditioning • long-term synaptic potentiation • grooming behavior • biological process involved in interspecies interaction between organisms • response to other organism • response to biotic stimulus • defense response to bacterium • defense response to other organism • response to bacterium • response to external biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • macromolecule metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • plasma membrane signaling receptor complex • G protein-coupled receptor complex • receptor complex • presynapse • presynaptic membrane • glutamatergic synapse • neuron spine • dendritic spine • somatodendritic compartment • dendrite • dendritic tree • GABA-ergic synapse • ciliary membrane • cell projection membrane • endoplasmic reticulum subcompartment • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • endoplasmic reticulum membrane • nucleus • host cellular component • host intracellular part • host cell cytoplasm • host cell part • host intracellular region
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	VFP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	VFP
Name	6-{4-[(furo[3,2-c]pyridin-4-yl)oxy]-2-methylphenyl}-1,5-dimethylpyrimidine-2,4(1H,3H)-dione
Synonyms
Identifier
Formula	C20 H17 N3 O4
Molecular Weight	363.367
SMILES
PubChem	75202022
Formal Charge	0
Total Atoms	44
Total Chiral Atoms	0
Total Bonds	47
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21728
Sequence	>7JOZ_nogp_Chain_R S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F R H L R S K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G F W P F G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S P F R Y E R K M T P K A A F I L I S V A W T L S V L I S F I P V Q L S W H N C D S S L S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C G S G E T Q P F C I D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F R K A F S T L L G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	10.1016/j.cell.2024.12.001
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8JXS	A	Amine	Dopamine	D₁	Homo sapiens	PF-6142	-	-	3	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8JXR	A	Amine	Dopamine	D₁	Homo sapiens	LSD	-	-	3.57	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	10.1038/s41467-023-40911-9
	8FD1 (Multimeric)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		4.25	2023-08-30	10.1038/s41467-023-40911-9
	8JD1	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	-	-	3.7	2023-06-21	10.1038/s41422-023-00830-2
	8IRR	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-	Gs/β1/γ2	3.2	2023-06-07	10.1038/s41422-023-00808-0
	8IRR (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-		3.2	2023-06-07	10.1038/s41422-023-00808-0
	7W41	A	Peptide	Bombesin	BB₂	Homo sapiens	PD176252	-	-	2.95	2023-02-22	10.1073/pnas.2216230120
	7X2C	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam	Gs/β1/γ2	3.2	2022-06-29	10.1038/s41467-022-30929-w
	7X2C (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam		3.2	2022-06-29	10.1038/s41467-022-30929-w
	7X2F	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3	2022-06-15	10.1038/s41467-022-30929-w
	7X2F (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3	2022-06-15	10.1038/s41467-022-30929-w
	7X2D	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-	Gs/β1/γ2	3.3	2022-06-15	10.1038/s41467-022-30929-w
	7X2D (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-		3.3	2022-06-15	10.1038/s41467-022-30929-w
	7F24	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	4.16	2022-06-15	10.1126/sciadv.abo4158
	7F24 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		4.16	2022-06-15	10.1126/sciadv.abo4158
	7F23	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.58	2022-06-15	10.1126/sciadv.abo4158
	7F23 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.58	2022-06-15	10.1126/sciadv.abo4158
	7F1Z	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.46	2022-06-15	10.1126/sciadv.abo4158
	7F1Z (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.46	2022-06-15	10.1126/sciadv.abo4158
	7F1O	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg	Gs/β1/γ2	3.13	2022-06-15	10.1126/sciadv.abo4158
	7F1O (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg		3.13	2022-06-15	10.1126/sciadv.abo4158
	7F0T	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-	Gs/β1/γ2	3.1	2022-06-15	10.1126/sciadv.abo4158
	7F0T (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-		3.1	2022-06-15	10.1126/sciadv.abo4158
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	10.1038/s41586-022-04619-y
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	10.1038/s41586-022-04580-w
	7QBI	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.46	2022-03-16	10.1038/s41586-022-04498-3
	7QBC	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.53	2022-03-16	10.1038/s41586-022-04498-3
	7QB9	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	-	-	-	3.1	2022-03-16	10.1038/s41586-022-04498-3
	7QA8	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	Peptide	-	-	2.7	2022-03-16	10.1038/s41586-022-04498-3
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	10.1038/s41467-022-28417-2
	7JOZ	A	Amine	Dopamine	D₁	Homo sapiens	VFP	-	Gs/β1/γ2	3.8	2021-04-14	10.1038/s41467-021-23519-9
	7JOZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	VFP	-		3.8	2021-04-14	10.1038/s41467-021-23519-9
	7CMV	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-	Gi1/β1/γ2	2.7	2021-03-10	10.1016/j.molcel.2021.01.003
	7CMV (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-		2.7	2021-03-10	10.1016/j.molcel.2021.01.003
	7LJD	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ1	3.2	2021-03-03	10.1038/s41422-021-00482-0
	7LJD (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.2	2021-03-03	10.1038/s41422-021-00482-0
	7LJC	A	Amine	Dopamine	D₁	Homo sapiens	SKF-81297	Mevidalen	Gs/β1/γ2	3	2021-03-03	10.1038/s41422-021-00482-0
	7LJC (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF-81297	Mevidalen		3	2021-03-03	10.1038/s41422-021-00482-0
	7CRH	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	3.3	2021-03-03	10.1016/j.cell.2021.01.028
	7CRH (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		3.3	2021-03-03	10.1016/j.cell.2021.01.028
	7CKZ	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3.1	2021-03-03	10.1016/j.cell.2021.01.028
	7CKZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.1	2021-03-03	10.1016/j.cell.2021.01.028
	7CKY	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-	Gs/β1/γ2	3.2	2021-03-03	10.1016/j.cell.2021.01.028
	7CKY (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-		3.2	2021-03-03	10.1016/j.cell.2021.01.028
	7CKX	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-	Gs/β1/γ2	3.54	2021-03-03	10.1016/j.cell.2021.01.028
	7CKX (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-		3.54	2021-03-03	10.1016/j.cell.2021.01.028
	7CKW	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	3.22	2021-03-03	10.1016/j.cell.2021.01.028
	7CKW (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-		3.22	2021-03-03	10.1016/j.cell.2021.01.028
	7JVQ	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-	Gs/β1/γ2	3	2021-02-24	10.1016/j.cell.2021.01.027
	7JVQ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-		3	2021-02-24	10.1016/j.cell.2021.01.027
	7JVP	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	2.9	2021-02-24	10.1016/j.cell.2021.01.027
	7JVP (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		2.9	2021-02-24	10.1016/j.cell.2021.01.027
	7JV5	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-	Gs/β1/γ2	3	2021-02-24	10.1016/j.cell.2021.01.027
	7JV5 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-		3	2021-02-24	10.1016/j.cell.2021.01.027
	7AD3	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	Gi1/STE4/γ2	3.3	2020-12-09	10.1038/s41586-020-2994-1
	7AD3 (No Gprot)	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-		3.3	2020-12-09	10.1038/s41586-020-2994-1
	4NTJ	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	AZD1283	-	-	2.62	2014-03-26	10.1038/nature13083

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