psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:V100	3.94	Yes	No	1	0	5
2	L:L:?1	R:R:D103	7.18	Yes	No	1	0	7
3	L:L:?1	R:R:I104	11.32	Yes	Yes	1	0	6
4	L:L:?1	R:R:S107	9.26	Yes	No	0	0	7
5	L:L:?1	R:R:L190	4.88	Yes	No	0	0	4
6	L:L:?1	R:R:S198	6.62	Yes	No	0	0	7
7	L:L:?1	R:R:S202	3.97	Yes	No	0	0	6
8	L:L:?1	R:R:F288	13.96	Yes	Yes	1	0	7
9	L:L:?1	R:R:F289	9.66	Yes	Yes	1	0	7
10	L:L:?1	R:R:N292	3.63	Yes	No	0	0	6
11	R:R:L25	R:R:S21	3	No	No	0	4	4
12	R:R:L30	R:R:W318	3.42	No	Yes	0	7	5
13	R:R:L35	R:R:S31	3	No	No	0	5	4
14	R:R:L33	R:R:T37	2.95	No	Yes	0	7	7
15	R:R:I34	R:R:M78	5.83	No	Yes	0	6	7
16	R:R:S325	R:R:S36	3.26	No	No	0	6	4
17	R:R:N41	R:R:T37	4.39	Yes	Yes	0	9	7
18	R:R:A74	R:R:T37	3.36	No	Yes	0	7	7
19	R:R:S325	R:R:T37	9.59	No	Yes	0	6	7
20	R:R:L38	R:R:V75	2.98	No	No	0	7	5
21	R:R:G40	R:R:L43	3.42	No	No	0	9	7
22	R:R:D70	R:R:N41	13.46	Yes	Yes	0	9	9
23	R:R:L71	R:R:N41	2.75	No	Yes	0	8	9
24	R:R:N41	R:R:P328	4.89	Yes	No	0	9	9
25	R:R:F341	R:R:L43	3.65	No	No	0	7	7
26	R:R:F341	R:R:V44	5.24	No	Yes	0	7	9
27	R:R:A47	R:R:F51	2.77	No	Yes	0	8	6
28	R:R:I64	R:R:V48	6.14	No	No	0	6	8
29	R:R:A340	R:R:F51	8.32	No	Yes	0	7	6
30	R:R:R52	R:R:R55	6.4	No	No	0	7	8
31	R:R:R52	R:R:S56	5.27	No	No	0	7	8
32	R:R:D336	R:R:L54	5.43	No	No	0	7	9
33	R:R:F337	R:R:L54	4.87	No	No	0	9	9
34	R:R:K57	R:R:T59	9.01	No	No	2	5	8
35	R:R:K57	R:R:N60	9.79	No	No	2	5	9
36	R:R:F61	R:R:V58	10.49	Yes	No	0	4	6
37	R:R:N60	R:R:T59	2.92	No	No	2	9	8
38	R:R:T59	R:R:Y131	4.99	No	Yes	0	8	7
39	R:R:N60	R:R:V63	5.91	No	No	0	9	8
40	R:R:A140	R:R:F61	2.77	No	Yes	0	7	4
41	R:R:F141	R:R:F61	8.57	No	Yes	0	3	4
42	R:R:F62	R:R:V116	5.24	Yes	No	0	8	7
43	R:R:D120	R:R:F62	11.94	No	Yes	0	9	8
44	R:R:A140	R:R:F62	2.77	No	Yes	0	7	8
45	R:R:F62	R:R:L143	3.65	Yes	No	0	8	7
46	R:R:F62	R:R:I144	5.02	Yes	No	0	8	8
47	R:R:N113	R:R:S65	7.45	No	No	0	8	9
48	R:R:I144	R:R:S65	3.1	No	No	0	8	9
49	R:R:D70	R:R:L66	4.07	Yes	Yes	1	9	9
50	R:R:L66	R:R:N113	2.75	Yes	No	0	9	8
51	R:R:L114	R:R:L66	5.54	No	Yes	1	9	9
52	R:R:L66	R:R:N327	8.24	Yes	No	1	9	9
53	R:R:L66	R:R:Y331	3.52	Yes	Yes	1	9	9
54	R:R:A109	R:R:S69	3.42	No	No	0	7	8
55	R:R:D70	R:R:S324	4.42	Yes	No	0	9	9
56	R:R:D70	R:R:N327	8.08	Yes	No	1	9	9
57	R:R:V73	R:R:V77	3.21	No	Yes	0	8	8
58	R:R:M78	R:R:V73	3.04	Yes	No	0	7	8
59	R:R:S324	R:R:V73	6.46	No	No	0	9	8
60	R:R:F102	R:R:L76	7.31	No	No	0	5	6
61	R:R:D103	R:R:V77	7.3	No	Yes	1	7	8
62	R:R:C106	R:R:V77	3.42	No	Yes	0	7	8
63	R:R:V77	R:R:W321	3.68	Yes	Yes	1	8	7
64	R:R:M78	R:R:P79	3.35	Yes	No	0	7	8
65	R:R:M78	R:R:W318	3.49	Yes	Yes	1	7	5
66	R:R:M78	R:R:W321	5.82	Yes	Yes	1	7	7
67	R:R:F92	R:R:W80	4.01	Yes	No	0	6	5
68	R:R:W80	R:R:W99	7.5	No	No	0	5	5
69	R:R:E85	R:R:K81	4.05	No	Yes	1	4	6
70	R:R:D314	R:R:K81	8.3	Yes	Yes	1	4	6
71	R:R:K81	R:R:W318	11.6	Yes	Yes	1	6	5
72	R:R:K81	R:R:W321	4.64	Yes	Yes	1	6	7
73	R:R:D314	R:R:E85	5.2	Yes	No	1	4	4
74	R:R:F92	R:R:W90	7.02	Yes	Yes	0	6	8
75	R:R:C186	R:R:W90	10.45	No	Yes	0	9	8
76	R:R:F92	R:R:F95	10.72	Yes	No	0	6	5
77	R:R:N97	R:R:S94	2.98	No	No	0	6	1
78	R:R:F95	R:R:I98	6.28	No	No	0	5	6
79	R:R:C186	R:R:C96	7.28	No	No	0	9	9
80	R:R:I98	R:R:N97	4.25	No	No	0	6	6
81	R:R:F102	R:R:I98	5.02	No	No	0	5	6
82	R:R:W321	R:R:W99	4.69	Yes	No	0	7	5
83	R:R:I104	R:R:V100	3.07	Yes	No	1	6	5
84	R:R:S162	R:R:V100	3.23	No	No	0	5	5
85	R:R:A101	R:R:F156	2.77	No	No	0	6	5
86	R:R:F102	R:R:F156	5.36	No	No	0	5	5
87	R:R:D103	R:R:W321	15.63	No	Yes	1	7	7
88	R:R:I104	R:R:S155	3.1	Yes	No	0	6	7
89	R:R:I104	R:R:Y194	6.04	Yes	Yes	0	6	7
90	R:R:M105	R:R:S151	3.07	No	No	0	5	8
91	R:R:M105	R:R:S155	4.6	No	No	0	5	7
92	R:R:I111	R:R:T108	3.04	Yes	Yes	1	8	6
93	R:R:L112	R:R:T108	2.95	Yes	Yes	1	5	6
94	R:R:S151	R:R:T108	3.2	No	Yes	0	8	6
95	R:R:S202	R:R:T108	6.4	No	Yes	0	6	6
96	R:R:I111	R:R:L112	2.85	Yes	Yes	1	8	5
97	R:R:F281	R:R:I111	3.77	Yes	Yes	1	9	8
98	R:R:I111	R:R:W285	3.52	Yes	Yes	1	8	8
99	R:R:A147	R:R:L112	3.15	No	Yes	0	7	5
100	R:R:L112	R:R:L150	2.77	Yes	No	0	5	4
101	R:R:L112	R:R:P206	3.28	Yes	No	0	5	9
102	R:R:F281	R:R:L114	3.65	Yes	No	1	9	9
103	R:R:L114	R:R:Y331	3.52	No	Yes	1	9	9
104	R:R:I117	R:R:Y331	8.46	No	Yes	0	9	9
105	R:R:M210	R:R:S118	7.67	Yes	No	1	8	8
106	R:R:S118	R:R:Y214	11.45	No	Yes	1	8	9
107	R:R:V119	R:R:W123	9.81	No	No	0	6	4
108	R:R:D120	R:R:Y131	10.34	No	Yes	0	9	7
109	R:R:R121	R:R:Y331	9.26	No	Yes	0	9	9
110	R:R:S126	R:R:Y122	6.36	No	Yes	0	7	8
111	R:R:T213	R:R:Y122	7.49	No	Yes	0	7	8
112	R:R:R216	R:R:Y122	8.23	No	Yes	0	5	8
113	R:R:I217	R:R:Y122	4.84	No	Yes	0	9	8
114	R:R:A124	R:R:Y131	9.34	No	Yes	0	8	7
115	R:R:I125	R:R:I217	4.42	No	No	0	8	9
116	R:R:S126	R:R:S127	3.26	No	No	0	7	6
117	R:R:R130	R:R:S127	3.95	No	No	0	5	6
118	R:R:R130	R:R:R133	6.4	No	No	3	5	4
119	R:R:K134	R:R:R130	4.95	No	No	3	5	5
120	R:R:M135	R:R:Y131	8.38	No	Yes	0	7	7
121	R:R:K134	R:R:R133	8.66	No	No	3	5	4
122	R:R:P137	R:R:T136	3.5	No	No	4	1	8
123	R:R:K138	R:R:T136	12.01	No	No	4	4	8
124	R:R:K138	R:R:P137	3.35	No	No	4	4	1
125	R:R:F141	R:R:I144	3.77	No	No	0	3	8
126	R:R:T149	R:R:V146	3.17	No	No	0	3	3
127	R:R:I154	R:R:S198	3.1	No	No	0	5	7
128	R:R:I154	R:R:I201	4.42	No	No	0	5	4
129	R:R:F156	R:R:S155	6.61	No	No	0	5	7
130	R:R:I157	R:R:V159	3.07	No	No	0	6	5
131	R:R:L161	R:R:V159	2.98	No	No	0	4	5
132	R:R:L161	R:R:Y194	4.69	No	Yes	0	4	7
133	R:R:H164	R:R:S191	5.58	No	No	0	5	5
134	R:R:C186	R:R:N185	3.15	No	No	0	9	4
135	R:R:P296	R:R:S189	7.13	No	No	0	5	4
136	R:R:L190	R:R:Y194	3.52	No	Yes	0	4	7
137	R:R:F289	R:R:S199	5.28	Yes	No	0	7	7
138	R:R:C293	R:R:S199	3.44	No	No	0	6	7
139	R:R:V200	R:R:Y204	7.57	No	No	0	4	5
140	R:R:F203	R:R:Y204	11.35	Yes	No	0	8	5
141	R:R:F203	R:R:V207	10.49	Yes	No	0	8	7
142	R:R:F203	R:R:L286	3.65	Yes	No	0	8	6
143	R:R:F203	R:R:F289	30.01	Yes	Yes	0	8	7
144	R:R:C293	R:R:Y204	5.38	No	No	0	6	5
145	R:R:I205	R:R:P206	3.39	No	No	0	5	9
146	R:R:I211	R:R:V207	3.07	No	No	0	6	7
147	R:R:F281	R:R:V207	5.24	Yes	No	0	9	7
148	R:R:M210	R:R:Y214	4.79	Yes	Yes	1	8	9
149	R:R:M210	R:R:M278	7.22	Yes	Yes	1	8	8
150	R:R:F281	R:R:M210	8.71	Yes	Yes	1	9	8
151	R:R:I211	R:R:M278	2.92	No	Yes	0	6	8
152	R:R:I277	R:R:Y214	8.46	No	Yes	0	8	9
153	R:R:R216	R:R:R219	6.4	No	No	0	5	4
154	R:R:I220	R:R:R216	3.76	No	No	0	6	5
155	R:R:Q222	R:R:Y218	5.64	No	Yes	0	6	7
156	R:R:E267	R:R:Y218	6.73	No	Yes	5	8	7
157	R:R:L271	R:R:Y218	9.38	No	Yes	5	7	7
158	R:R:L274	R:R:Y218	3.52	No	Yes	0	8	7
159	R:R:A230	R:R:R226	2.77	No	No	0	4	5
160	R:R:I228	R:R:R266	6.26	No	No	0	7	6
161	R:R:H237	R:R:R233	3.39	No	No	0	1	1
162	R:R:F264	R:R:S263	3.96	No	No	0	5	5
163	R:R:E267	R:R:L271	3.98	No	No	5	8	7
164	R:R:K272	R:R:V276	6.07	No	No	0	7	7
165	R:R:I277	R:R:I330	2.94	No	Yes	0	8	8
166	R:R:F281	R:R:M278	3.73	Yes	Yes	1	9	8
167	R:R:M278	R:R:V282	3.04	Yes	No	0	8	7
168	R:R:I330	R:R:V280	4.61	Yes	No	0	8	7
169	R:R:F281	R:R:W285	4.01	Yes	Yes	1	9	8
170	R:R:C284	R:R:N323	9.45	No	No	0	9	9
171	R:R:F288	R:R:W285	4.01	Yes	Yes	1	7	8
172	R:R:F289	R:R:W285	3.01	Yes	Yes	1	7	8
173	R:R:W285	R:R:W321	2.81	Yes	Yes	1	8	7
174	R:R:N323	R:R:W285	6.78	No	Yes	0	9	8
175	R:R:L286	R:R:P287	3.28	No	No	0	6	9
176	R:R:I290	R:R:L286	2.85	No	No	0	7	6
177	R:R:F288	R:R:F289	7.5	Yes	Yes	1	7	7
178	R:R:F288	R:R:V317	5.24	Yes	No	0	7	6
179	R:R:F306	R:R:L291	4.87	No	No	6	1	5
180	R:R:I308	R:R:L291	2.85	No	No	6	4	5
181	R:R:F313	R:R:L291	3.65	No	No	0	4	5
182	R:R:F313	R:R:N292	6.04	No	No	0	4	6
183	R:R:L295	R:R:P296	3.28	No	No	0	3	5
184	R:R:F313	R:R:L295	7.31	No	No	0	4	3
185	R:R:C298	R:R:C307	5.46	No	No	0	4	3
186	R:R:G301	R:R:S300	3.71	No	No	0	3	1
187	R:R:P305	R:R:T303	10.49	No	No	0	1	1
188	R:R:C307	R:R:T303	6.76	No	No	0	3	1
189	R:R:P305	R:R:Q304	3.16	No	No	0	1	4
190	R:R:F306	R:R:I308	5.02	No	No	6	1	4
191	R:R:I308	R:R:T312	4.56	No	No	0	4	4
192	R:R:F316	R:R:T312	3.89	No	No	0	5	4
193	R:R:D314	R:R:V317	2.92	Yes	No	0	4	6
194	R:R:D314	R:R:W318	3.35	Yes	Yes	1	4	5
195	R:R:V317	R:R:W321	8.58	No	Yes	0	6	7
196	R:R:W318	R:R:W321	6.56	Yes	Yes	1	5	7
197	R:R:N323	R:R:N327	4.09	No	No	0	9	9
198	R:R:F333	R:R:I329	8.79	No	No	0	8	7
199	R:R:A332	R:R:F337	2.77	No	No	0	6	9
200	R:R:F333	R:R:R338	20.31	No	No	0	8	8
201	R:R:D336	R:R:N334	5.39	No	No	0	7	8
202	R:R:F337	R:R:N334	4.83	No	No	0	9	8
203	R:R:K339	R:R:T343	3	No	No	0	5	4
204	R:R:F92	R:R:V83	2.62	Yes	No	0	6	4
205	R:R:A84	R:R:W90	2.59	No	Yes	0	5	8
206	R:R:A109	R:R:W148	2.59	No	Yes	0	7	9
207	R:R:V270	R:R:Y218	2.52	No	Yes	0	8	7
208	R:R:I49	R:R:R55	2.51	No	No	0	4	8
209	R:R:I225	R:R:R266	2.51	No	No	0	5	6
210	R:R:T213	R:R:Y214	2.5	No	Yes	0	7	9
211	R:R:H164	R:R:Q160	2.47	No	No	0	5	5
212	R:R:F29	R:R:L30	2.44	No	No	0	3	7
213	R:R:F51	R:R:L344	2.44	Yes	No	0	6	6
214	R:R:F341	R:R:L344	2.44	No	No	0	7	6
215	R:R:M105	R:R:W148	2.33	No	Yes	0	5	9
216	R:R:M135	R:R:W123	2.33	No	No	0	7	4
217	R:R:E132	R:R:F129	2.33	No	No	0	5	7
218	R:R:L72	R:R:W148	2.28	No	Yes	0	7	9
219	R:R:F51	R:R:R50	2.14	Yes	No	0	6	6
220	R:R:C115	R:R:P206	1.88	No	No	0	7	9
221	R:R:A332	R:R:P328	1.87	No	No	0	6	9
222	R:R:G299	R:R:S300	1.86	No	No	0	1	1
223	R:R:G279	R:R:V282	1.84	No	No	0	5	7
224	R:R:C283	R:R:C284	1.82	No	No	0	5	9
225	R:R:A67	R:R:C45	1.81	No	No	0	9	7
226	R:R:P128	R:R:S127	1.78	No	No	0	8	6
227	R:R:G40	R:R:L39	1.71	No	No	0	9	4
228	R:R:A67	R:R:V44	1.7	No	Yes	0	9	9
229	R:R:A332	R:R:V44	1.7	No	Yes	0	6	9
230	R:R:I157	R:R:P158	1.69	No	No	0	6	6
231	R:R:I294	R:R:P305	1.69	No	No	0	5	1
232	R:R:A139	R:R:T136	1.68	No	No	0	6	8
233	R:R:C28	R:R:I24	1.64	No	No	0	5	6
234	R:R:C115	R:R:I209	1.64	No	No	0	7	6
235	R:R:E302	R:R:G301	1.64	No	No	0	3	3
236	R:R:S110	R:R:S69	1.63	No	No	0	9	8
237	R:R:S151	R:R:V152	1.62	No	No	0	8	4
238	R:R:V44	R:R:V48	1.6	Yes	No	0	9	8
239	R:R:C284	R:R:L326	1.59	No	No	0	9	6
240	R:R:C298	R:R:L295	1.59	No	No	0	4	3
241	R:R:A82	R:R:L30	1.58	No	No	0	6	7
242	R:R:A322	R:R:L33	1.58	No	No	0	4	7
243	R:R:A74	R:R:L38	1.58	No	No	0	7	7
244	R:R:A195	R:R:L190	1.58	No	No	0	5	4
245	R:R:A335	R:R:N334	1.56	No	No	0	5	8
246	R:R:I196	R:R:S197	1.55	No	No	0	6	4
247	R:R:I49	R:R:V48	1.54	No	No	0	4	8
248	R:R:I330	R:R:V276	1.54	Yes	No	0	8	7
249	R:R:I211	R:R:T215	1.52	No	No	0	6	3
250	R:R:K239	R:R:V236	1.52	No	No	0	3	4
251	R:R:F319	R:R:G320	1.51	No	No	0	7	7
252	R:R:L143	R:R:V146	1.49	No	No	0	7	3
253	R:R:L39	R:R:T42	1.47	No	No	0	4	5
254	R:R:L71	R:R:T42	1.47	No	No	0	8	5
255	R:R:D187	R:R:S310	1.47	No	No	0	5	1
256	R:R:L274	R:R:T273	1.47	No	No	0	8	9
257	R:R:D309	R:R:S310	1.47	No	No	0	4	1
258	R:R:I329	R:R:I330	1.47	No	Yes	0	7	8
259	R:R:F61	R:R:P137	1.44	Yes	No	0	4	1
260	R:R:I24	R:R:L25	1.43	No	No	0	6	4
261	R:R:G88	R:R:W90	1.41	No	Yes	0	4	8
262	R:R:L150	R:R:L153	1.38	No	No	0	4	4
263	R:R:A230	R:R:R227	1.38	No	No	0	4	5
264	R:R:P91	R:R:W90	1.35	No	Yes	0	1	8
265	R:R:F51	R:R:T343	1.3	Yes	No	0	6	4
266	R:R:H53	R:R:L54	1.29	No	No	0	6	9
267	R:R:S191	R:R:Y194	1.27	No	Yes	0	5	7
268	R:R:V68	R:R:W148	1.23	No	Yes	0	6	9
269	L:L:?1	R:R:D187	1.2	Yes	No	0	0	5
270	R:R:L274	R:R:Y214	1.17	No	Yes	0	8	9
271	R:R:E232	R:R:R266	1.16	No	No	0	3	6
272	R:R:N97	R:R:W163	1.13	No	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.87454	11	1	0
2	R:R:T37	5.0725	4	0	7
3	R:R:N41	6.3725	4	0	9
4	R:R:V44	2.56	4	0	9
5	R:R:F51	3.394	5	0	6
6	R:R:F61	5.8175	4	0	4
7	R:R:F62	5.724	5	0	8
8	R:R:L66	4.824	5	1	9
9	R:R:D70	7.5075	4	1	9
10	R:R:V77	4.4025	4	1	8
11	R:R:M78	4.306	5	1	7
12	R:R:K81	7.1475	4	1	6
13	R:R:W90	4.564	5	0	8
14	R:R:F92	6.0925	4	0	6
15	R:R:I104	5.8825	4	1	6
16	R:R:T108	3.8975	4	1	6
17	R:R:I111	3.295	4	1	8
18	R:R:L112	3	5	1	5
19	R:R:Y122	6.73	4	0	8
20	R:R:Y131	8.2625	4	0	7
21	R:R:W148	2.1075	4	0	9
22	R:R:Y194	3.88	4	0	7
23	R:R:F203	13.875	4	0	8
24	R:R:M210	7.0975	4	1	8
25	R:R:Y214	5.674	5	1	9
26	R:R:Y218	5.558	5	5	7
27	R:R:M278	4.2275	4	1	8
28	R:R:F281	4.85167	6	1	9
29	R:R:W285	4.02333	6	1	8
30	R:R:F288	7.6775	4	1	7
31	R:R:F289	11.092	5	1	7
32	R:R:D314	4.9425	4	1	4
33	R:R:W318	5.684	5	1	5
34	R:R:W321	6.55125	8	1	7
35	R:R:I330	2.64	4	0	8
36	R:R:Y331	6.19	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	24.1439	7.18	Yes	No	1	0	7
2	R:R:D103	R:R:V77	16.6991	7.3	No	Yes	1	7	8
3	R:R:V73	R:R:V77	23.2862	3.21	No	Yes	0	8	8
4	R:R:S324	R:R:V73	33.2976	6.46	No	No	0	9	8
5	R:R:D70	R:R:S324	33.2574	4.42	Yes	No	0	9	9
6	R:R:D70	R:R:N41	100	13.46	Yes	Yes	0	9	9
7	R:R:N41	R:R:T37	21.2759	4.39	Yes	Yes	0	9	7
8	L:L:?1	R:R:F288	49.3735	13.96	Yes	Yes	1	0	7
9	R:R:F288	R:R:W285	50.9013	4.01	Yes	Yes	1	7	8
10	R:R:N323	R:R:W285	74.9648	6.78	No	Yes	0	9	8
11	R:R:N323	R:R:N327	71.3462	4.09	No	No	0	9	9
12	R:R:D70	R:R:N327	44.9977	8.08	Yes	No	1	9	9
13	L:L:?1	R:R:F289	53.1059	9.66	Yes	Yes	1	0	7
14	R:R:F289	R:R:W285	55.0627	3.01	Yes	Yes	1	7	8
15	R:R:L71	R:R:N41	12.8526	2.75	No	Yes	0	8	9
16	R:R:L71	R:R:T42	10.2593	1.47	No	No	0	8	5
17	R:R:N41	R:R:P328	67.8416	4.89	Yes	No	0	9	9
18	R:R:A332	R:R:P328	65.4962	1.87	No	No	0	6	9
19	R:R:A332	R:R:V44	46.358	1.7	No	Yes	0	6	9
20	R:R:F341	R:R:V44	23.9228	5.24	No	Yes	0	7	9
21	R:R:F341	R:R:L344	18.6625	2.44	No	No	0	7	6
22	R:R:F51	R:R:L344	16.0356	2.44	Yes	No	0	6	6
23	R:R:V44	R:R:V48	16.0356	1.6	Yes	No	0	9	8
24	R:R:I49	R:R:V48	10.7418	1.54	No	No	0	4	8
25	R:R:A332	R:R:F337	18.6625	2.77	No	No	0	6	9
26	R:R:F281	R:R:W285	64.0287	4.01	Yes	Yes	1	9	8
27	R:R:F281	R:R:L114	62.3869	3.65	Yes	No	1	9	9
28	R:R:L114	R:R:L66	57.1869	5.54	No	Yes	1	9	9
29	R:R:L66	R:R:N113	70.904	2.75	Yes	No	0	9	8
30	R:R:N113	R:R:S65	68.3442	7.45	No	No	0	8	9
31	R:R:I144	R:R:S65	65.771	3.1	No	No	0	8	9
32	R:R:F62	R:R:I144	44.0528	5.02	Yes	No	0	8	8
33	R:R:D120	R:R:F62	28.3388	11.94	No	Yes	0	9	8
34	R:R:D120	R:R:Y131	25.5646	10.34	No	Yes	0	9	7
35	R:R:T59	R:R:Y131	11.4923	4.99	No	Yes	0	8	7
36	R:R:L66	R:R:N327	25.7254	8.24	Yes	No	1	9	9
37	R:R:F141	R:R:I144	19.3259	3.77	No	No	0	3	8
38	R:R:F141	R:R:F61	16.5248	8.57	No	Yes	0	3	4
39	L:L:?1	R:R:I104	40.8229	11.32	Yes	Yes	1	0	6
40	R:R:I104	R:R:S155	18.7362	3.1	Yes	No	0	6	7
41	R:R:M105	R:R:W148	10.8624	2.33	No	Yes	0	5	9
42	R:R:F156	R:R:S155	16.4243	6.61	No	No	0	5	7
43	R:R:F102	R:R:F156	10.2057	5.36	No	No	0	5	5
44	R:R:W321	R:R:W99	32.6275	4.69	Yes	No	0	7	5
45	R:R:W80	R:R:W99	30.5569	7.5	No	No	0	5	5
46	R:R:F92	R:R:W80	28.4795	4.01	Yes	No	0	6	5
47	R:R:F92	R:R:W90	16.5047	7.02	Yes	Yes	0	6	8
48	R:R:F92	R:R:F95	10.7485	10.72	Yes	No	0	6	5
49	L:L:?1	R:R:L190	27.3068	4.88	Yes	No	0	0	4
50	R:R:L190	R:R:Y194	21.946	3.52	No	Yes	0	4	7
51	R:R:S151	R:R:T108	14.9702	3.2	No	Yes	0	8	6
52	R:R:I111	R:R:T108	16.0356	3.04	Yes	Yes	1	8	6
53	R:R:I111	R:R:W285	11.1774	3.52	Yes	Yes	1	8	8
54	R:R:F281	R:R:M210	53.0322	8.71	Yes	Yes	1	9	8
55	R:R:M210	R:R:Y214	50.7673	4.79	Yes	Yes	1	8	9
56	R:R:T213	R:R:Y214	24.2981	2.5	No	Yes	0	7	9
57	R:R:T213	R:R:Y122	22.5089	7.49	No	Yes	0	7	8
58	R:R:S126	R:R:Y122	11.4923	6.36	No	Yes	0	7	8
59	R:R:F61	R:R:P137	11.4923	1.44	Yes	No	0	4	1
60	R:R:I104	R:R:Y194	23.4805	6.04	Yes	Yes	0	6	7
61	R:R:L161	R:R:Y194	22.5893	4.69	No	Yes	0	4	7
62	R:R:L161	R:R:V159	16.9604	2.98	No	No	0	4	5
63	R:R:I157	R:R:V159	11.3181	3.07	No	No	0	6	5
64	R:R:S191	R:R:Y194	16.9604	1.27	No	Yes	0	5	7
65	R:R:H164	R:R:S191	11.3181	5.58	No	No	0	5	5
66	L:L:?1	R:R:N292	45.8822	3.63	Yes	No	0	0	6
67	R:R:F313	R:R:N292	43.1147	6.04	No	No	0	4	6
68	R:R:F313	R:R:L295	26.228	7.31	No	No	0	4	3
69	R:R:I277	R:R:Y214	15.2181	8.46	No	Yes	0	8	9
70	R:R:L274	R:R:Y214	13.2212	1.17	No	Yes	0	8	9
71	R:R:I277	R:R:I330	13.3619	2.94	No	Yes	0	8	8
72	R:R:F313	R:R:L291	14.7021	3.65	No	No	0	4	5
73	R:R:C298	R:R:L295	17.6037	1.59	No	No	0	4	3
74	R:R:C298	R:R:C307	14.7021	5.46	No	No	0	4	3
75	R:R:C307	R:R:T303	11.7872	6.76	No	No	0	3	1
76	R:R:M105	R:R:S151	11.8743	3.07	No	No	0	5	8
77	R:R:D70	R:R:L66	30.1883	4.07	Yes	Yes	1	9	9
78	R:R:W285	R:R:W321	32.3527	2.81	Yes	Yes	1	8	7
79	R:R:I111	R:R:L112	11.4588	2.85	Yes	Yes	1	8	5
80	R:R:F281	R:R:I111	17.8918	3.77	Yes	Yes	1	9	8
81	R:R:M78	R:R:V73	11.3047	3.04	Yes	No	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:V100	3.94	1	Yes	No	0	5	0	1
L:L:?1	R:R:D103	7.18	1	Yes	No	0	7	0	1
L:L:?1	R:R:I104	11.32	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S107	9.26	1	Yes	No	0	7	0	1
L:L:?1	R:R:L190	4.88	1	Yes	No	0	4	0	1
L:L:?1	R:R:S198	6.62	1	Yes	No	0	7	0	1
L:L:?1	R:R:S202	3.97	1	Yes	No	0	6	0	1
L:L:?1	R:R:F288	13.96	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F289	9.66	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N292	3.63	1	Yes	No	0	6	0	1
R:R:D103	R:R:V77	7.3	1	No	Yes	7	8	1	2
R:R:V77	R:R:W321	3.68	1	Yes	Yes	8	7	2	2
R:R:I104	R:R:V100	3.07	1	Yes	No	6	5	1	1
R:R:S162	R:R:V100	3.23	0	No	No	5	5	2	1
R:R:D103	R:R:W321	15.63	1	No	Yes	7	7	1	2
R:R:I104	R:R:S155	3.1	1	Yes	No	6	7	1	2
R:R:I104	R:R:Y194	6.04	1	Yes	Yes	6	7	1	2
R:R:S202	R:R:T108	6.4	0	No	Yes	6	6	1	2
R:R:I154	R:R:S198	3.1	0	No	No	5	7	2	1
R:R:L190	R:R:Y194	3.52	0	No	Yes	4	7	1	2
R:R:F289	R:R:S199	5.28	1	Yes	No	7	7	1	2
R:R:F203	R:R:F289	30.01	0	Yes	Yes	8	7	2	1
R:R:F288	R:R:W285	4.01	1	Yes	Yes	7	8	1	2
R:R:F289	R:R:W285	3.01	1	Yes	Yes	7	8	1	2
R:R:W285	R:R:W321	2.81	1	Yes	Yes	8	7	2	2
R:R:F288	R:R:F289	7.5	1	Yes	Yes	7	7	1	1
R:R:F288	R:R:V317	5.24	1	Yes	No	7	6	1	2
R:R:F313	R:R:N292	6.04	0	No	No	4	6	2	1
R:R:V317	R:R:W321	8.58	0	No	Yes	6	7	2	2
R:R:A195	R:R:L190	1.58	0	No	No	5	4	2	1
R:R:D187	R:R:S310	1.47	0	No	No	5	1	1	2
L:L:?1	R:R:D187	1.2	1	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7JOZ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.75
Number of Linked Nodes	249
Number of Links	272
Number of Hubs	36
Number of Links mediated by Hubs	137
Number of Communities	6
Number of Nodes involved in Communities	42
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	42356
Length Of Smallest Path	3
Average Path Length	11.8515
Length of Longest Path	23
Minimum Path Strength	1.32
Average Path Strength	5.39922
Maximum Path Strength	20.68
Minimum Path Correlation	0.7
Average Path Correlation	0.950292
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	7.69231
Average % Of Corr. Nodes	66.5062
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.4052
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • hydrolase activity • catalytic activity • protein binding • binding • arrestin family protein binding • neurotransmitter receptor activity • dopamine neurotransmitter receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • dopamine neurotransmitter receptor activity, coupled via Gs • cation binding • ion binding • catecholamine binding • dopamine binding • small molecule binding • G-protein alpha-subunit binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • protein-containing complex binding • heterotrimeric G-protein binding • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process
Gene Ontology	Biological Process	• defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • metabolic process • cellular process • macromolecule metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • response to chemical • response to xenobiotic stimulus • behavior • multicellular organismal process • system process • learning • learning or memory • nervous system process • feeding behavior • cognition • associative learning • conditioned taste aversion • trans-synaptic signaling • regulation of biological process • regulation of signaling • regulation of cellular process • modulation of chemical synaptic transmission • signaling • biological regulation • cell-cell signaling • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • cell communication • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • reproductive process • multicellular organismal reproductive process • reproductive behavior • mating behavior • nonassociative learning • habituation • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • signal transduction • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • G protein-coupled receptor signaling pathway • memory • establishment of protein localization • cellular localization • nucleocytoplasmic transport • transport • nuclear transport • intracellular transport • protein localization to nucleus • establishment of localization • localization • import into nucleus • establishment of protein localization to organelle • protein transport • establishment of localization in cell • macromolecule localization • protein localization to organelle • protein import into nucleus • intracellular protein localization • intracellular protein transport • cellular developmental process • forebrain development • central nervous system neuron development • cell development • substrate-independent telencephalic tangential migration • cerebral cortex GABAergic interneuron differentiation • interneuron migration • multicellular organism development • neurogenesis • central nervous system neuron differentiation • telencephalon cell migration • forebrain cell migration • neuron differentiation • cell differentiation • substrate-independent telencephalic tangential interneuron migration • cerebral cortex GABAergic interneuron migration • anatomical structure development • cell migration • cell motility • GABAergic neuron differentiation • system development • developmental process • head development • interneuron migration from the subpallium to the cortex • neuron migration • forebrain generation of neurons • animal organ development • brain development • nervous system development • cerebral cortex GABAergic interneuron development • generation of neurons • forebrain neuron development • central nervous system development • neuron development • telencephalon development • cerebral cortex neuron differentiation • forebrain neuron differentiation • astrocyte differentiation • glial cell development • astrocyte development • gliogenesis • glial cell differentiation • regulation of localization • regulation of potassium ion transport • regulation of transport • regulation of monoatomic ion transport • positive regulation of biological process • metal ion transport • positive regulation of potassium ion transport • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • potassium ion transport • monoatomic cation transport • regulation of metal ion transport • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • transmission of nerve impulse • striatum development • subpallium development • adult walking behavior • adult locomotory behavior • adult behavior • locomotory behavior • walking behavior • adenylate cyclase-activating dopamine receptor signaling pathway • cellular component organization • cellular component biogenesis • cell junction organization • cellular component assembly • cell junction assembly • synapse organization • cellular component organization or biogenesis • synapse assembly • phospholipase C-activating dopamine receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • peristalsis • muscle system process • modification of postsynaptic structure • modification of synaptic structure • behavioral response to cocaine • response to cocaine • response to alkaloid • positive regulation of cell communication • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • positive regulation of cellular process • positive regulation of synaptic transmission • positive regulation of synaptic transmission, glutamatergic • positive regulation of signaling • maternal behavior • parental behavior • sensitization • positive regulation of locomotion • regulation of cell motility • regulation of neuron migration • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • locomotion • regulation of locomotion • positive regulation of neuron migration • monoamine transport • import into cell • nitrogen compound transport • organic hydroxy compound transport • dopamine transport • catecholamine uptake • dopamine uptake involved in synaptic transmission • catecholamine transport • regulation of dopamine uptake involved in synaptic transmission • neurotransmitter reuptake • regulation of neurotransmitter uptake • regulation of neurotransmitter transport • neurotransmitter transport • neurotransmitter uptake • synaptic transmission, dopaminergic • dopamine uptake • response to light stimulus • visual learning • visual behavior • response to radiation • response to abiotic stimulus • action potential • neuronal action potential • regulation of biological quality • regulation of membrane potential • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • dentate gyrus development • pallium development • hippocampus development • limbic system development • multicellular organismal-level homeostasis • homeostatic process • temperature homeostasis • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • monoatomic ion transmembrane transport • regulation of monoatomic ion transmembrane transport • calcium ion transport • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • positive regulation of monoatomic ion transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • calcium ion transmembrane import into cytosol • regulation of release of sequestered calcium ion into cytosol • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • response to amine • response to amphetamine • behavioral defense response • fear response • behavioral fear response • multicellular organismal response to stress • negative regulation of signaling • negative regulation of biological process • negative regulation of synaptic transmission • negative regulation of cell communication • negative regulation of cellular process • regulation of synaptic plasticity • long-term synaptic depression • operant conditioning • long-term synaptic potentiation • grooming behavior • host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • cell periphery • postsynapse • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane
Gene Ontology	Cellular Component	• host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • cell periphery • postsynapse • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • plasma membrane protein complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • membrane protein complex • receptor complex • presynapse • presynaptic membrane • glutamatergic synapse • neuron spine • neuron projection • dendritic spine • plasma membrane bounded cell projection • somatodendritic compartment • cell projection • dendrite • dendritic tree • membrane-bounded organelle • organelle • cilium • non-motile cilium • GABA-ergic synapse • ciliary membrane • bounding membrane of organelle • organelle membrane • cell projection membrane • intracellular anatomical structure • organelle subcompartment • intracellular membrane-bounded organelle • endomembrane system • endoplasmic reticulum subcompartment • intracellular organelle • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • cytoplasm • endoplasmic reticulum membrane • nucleus • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	VFP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	VFP
Name	6-{4-[(furo[3,2-c]pyridin-4-yl)oxy]-2-methylphenyl}-1,5-dimethylpyrimidine-2,4(1H,3H)-dione
Synonyms
Identifier
Formula	C20 H17 N3 O4
Molecular Weight	363.367
SMILES
PubChem	75202022
Formal Charge	0
Total Atoms	44
Total Chiral Atoms	0
Total Bonds	47
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21728
Sequence	>7JOZ_nogp_Chain_R S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F R H L R S K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G F W P F G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S P F R Y E R K M T P K A A F I L I S V A W T L S V L I S F I P V Q L S W H N C D S S L S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C G S G E T Q P F C I D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F R K A F S T L L G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4NTJ	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	AZD1283	-	-	2.62	2014-03-26	doi.org/10.1038/nature13083
	7AD3	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	Gi1/STE4/γ2	3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7AD3 (No Gprot)	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-		3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7JV5	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JV5 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7CKW	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKW (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-		3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-	Gs/β1/γ2	3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-		3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-	Gs/β1/γ2	3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-		3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKZ	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7LJC	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	Mevidalen	Gs/β1/γ2	3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJC (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	Mevidalen		3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ1	3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7CMV	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-	Gi1/β1/γ2	2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7CMV (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-		2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7JOZ	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 75202022	-	Gs/β1/γ2	3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7JOZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 75202022	-		3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7QA8	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	Antagonist Peptide	-	-	2.7	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QB9	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	-	-	-	3.1	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBC	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.53	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBI	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.46	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7F0T	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-	Gs/β1/γ2	3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F0T (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-		3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1O	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg	Gs/β1/γ2	3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1O (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg		3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7X2D	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-	Gs/β1/γ2	3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2D (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-		3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2F	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2F (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2C	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam	Gs/β1/γ2	3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7X2C (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam		3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7W41	A	Peptide	Bombesin	BB₂	Homo sapiens	PD176252	-	-	2.95	2023-02-22	doi.org/10.1073/pnas.2216230120
	8IRR	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-	Gs/β1/γ2	3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8IRR (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-		3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8JD1	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	-	-	3.7	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8JXR	A	Amine	Dopamine	D₁	Homo sapiens	LSD	-	-	3.57	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8JXS	A	Amine	Dopamine	D₁	Homo sapiens	PF-6142	-	-	3	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JF4	A	Peptide	Bombesin	BB₁	Homo sapiens	PD168368	-	-	3.6	2025-07-09	To be published
	9I52	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-	Gs/β1/γ2	2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I52 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-		2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 176452091	-	Gs/β1/γ2	2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 176452091	-		2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9V0U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9V0U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.