psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F20	R:R:S21	7.93	No	No	0	1	4
2	R:R:F20	R:R:V22	5.24	No	No	0	1	4
3	R:R:L25	R:R:V22	5.96	No	No	0	4	4
4	R:R:I86	R:R:R23	3.76	No	No	0	5	5
5	R:R:C28	R:R:I24	3.27	No	No	0	5	6
6	R:R:A27	R:R:I86	3.25	No	No	0	6	5
7	R:R:F29	R:R:L30	3.65	No	No	0	3	7
8	R:R:L30	R:R:W318	9.11	No	Yes	0	7	5
9	R:R:L35	R:R:S31	4.5	No	No	0	5	4
10	R:R:S325	R:R:S36	3.26	No	No	0	6	4
11	R:R:A74	R:R:T37	3.36	No	No	0	7	7
12	R:R:M78	R:R:T37	4.52	Yes	No	0	7	7
13	R:R:S325	R:R:T37	6.4	No	No	0	6	7
14	R:R:A74	R:R:L38	3.15	No	No	0	7	7
15	R:R:D70	R:R:N41	13.46	Yes	No	0	9	9
16	R:R:N41	R:R:P328	8.15	No	No	0	9	9
17	R:R:L345	R:R:L43	4.15	No	No	0	7	7
18	R:R:A67	R:R:V44	3.39	No	No	0	9	9
19	R:R:R55	R:R:V48	3.92	No	No	0	8	8
20	R:R:I64	R:R:V48	9.22	No	No	0	6	8
21	R:R:F51	R:R:H53	10.18	Yes	No	2	6	6
22	R:R:F51	R:R:L54	4.87	Yes	No	2	6	9
23	R:R:F51	R:R:T343	3.89	Yes	No	0	6	4
24	R:R:F51	R:R:L344	4.87	Yes	No	0	6	6
25	R:R:R52	R:R:R55	13.86	No	No	0	7	8
26	R:R:H53	R:R:L54	7.71	No	No	2	6	9
27	R:R:D336	R:R:L54	4.07	No	No	0	7	9
28	R:R:K57	R:R:T59	6.01	No	No	0	5	8
29	R:R:K57	R:R:N60	5.6	No	No	0	5	9
30	R:R:F61	R:R:V58	5.24	Yes	No	0	4	6
31	R:R:M135	R:R:V58	4.56	No	No	0	7	6
32	R:R:D120	R:R:T59	11.56	No	No	3	9	8
33	R:R:T59	R:R:Y131	3.75	No	Yes	3	8	7
34	R:R:F62	R:R:V116	3.93	Yes	No	0	8	7
35	R:R:F62	R:R:I117	3.77	Yes	No	0	8	9
36	R:R:D120	R:R:F62	7.17	No	Yes	0	9	8
37	R:R:N113	R:R:S65	10.43	No	No	0	8	9
38	R:R:I144	R:R:S65	3.1	No	No	0	8	9
39	R:R:L66	R:R:N113	6.87	Yes	No	0	9	8
40	R:R:L114	R:R:L66	5.54	No	Yes	0	9	9
41	R:R:I117	R:R:L66	4.28	No	Yes	0	9	9
42	R:R:L66	R:R:N327	4.12	Yes	No	0	9	9
43	R:R:A109	R:R:S69	3.42	No	No	0	7	8
44	R:R:S110	R:R:S69	3.26	No	No	0	9	8
45	R:R:D70	R:R:S110	4.42	Yes	No	0	9	9
46	R:R:D70	R:R:S324	5.89	Yes	No	0	9	9
47	R:R:D70	R:R:N327	8.08	Yes	No	0	9	9
48	R:R:C106	R:R:L72	4.76	No	No	0	7	7
49	R:R:M78	R:R:V73	4.56	Yes	No	0	7	8
50	R:R:C106	R:R:V73	3.42	No	No	0	7	8
51	R:R:S324	R:R:V73	6.46	No	No	0	9	8
52	R:R:F102	R:R:L76	4.87	No	No	0	5	6
53	R:R:V77	R:R:W99	3.68	No	Yes	1	8	5
54	R:R:D103	R:R:V77	5.84	Yes	No	1	7	8
55	R:R:V77	R:R:W321	3.68	No	Yes	1	8	7
56	R:R:M78	R:R:W318	6.98	Yes	Yes	1	7	5
57	R:R:M78	R:R:W321	9.31	Yes	Yes	1	7	7
58	R:R:P79	R:R:W80	4.05	No	No	0	8	5
59	R:R:W80	R:R:W99	8.43	No	Yes	0	5	5
60	R:R:K81	R:R:W99	8.12	No	Yes	0	6	5
61	R:R:D314	R:R:K81	9.68	No	No	0	4	6
62	R:R:K81	R:R:W321	5.8	No	Yes	0	6	7
63	R:R:D314	R:R:E85	18.19	No	No	0	4	4
64	R:R:A87	R:R:F89	4.16	No	No	0	5	4
65	R:R:P91	R:R:W90	6.76	No	Yes	1	1	8
66	R:R:F92	R:R:W90	13.03	No	Yes	1	6	8
67	R:R:G93	R:R:W90	4.22	No	Yes	0	7	8
68	R:R:F95	R:R:W90	6.01	No	Yes	0	5	8
69	R:R:C96	R:R:W90	10.45	No	Yes	1	9	8
70	R:R:C186	R:R:W90	6.53	No	Yes	1	9	8
71	R:R:F92	R:R:P91	7.22	No	No	1	6	1
72	R:R:C96	R:R:W99	3.92	No	Yes	1	9	5
73	R:R:C186	R:R:C96	7.28	No	No	1	9	9
74	R:R:D103	R:R:W99	3.35	Yes	Yes	1	7	5
75	R:R:I104	R:R:V100	3.07	No	No	0	6	5
76	R:R:A101	R:R:V159	5.09	No	No	0	6	5
77	R:R:F102	R:R:F156	6.43	No	No	0	5	5
78	R:R:D103	R:R:S107	4.42	Yes	No	1	7	7
79	R:R:D103	R:R:W321	5.58	Yes	Yes	1	7	7
80	L:L:?1	R:R:D103	13.39	Yes	Yes	1	0	7
81	R:R:I104	R:R:Y194	8.46	No	Yes	0	6	7
82	L:L:?1	R:R:I104	17.93	Yes	No	0	0	6
83	R:R:C106	R:R:M105	3.24	No	No	0	7	5
84	R:R:M105	R:R:S151	3.07	No	Yes	0	5	8
85	R:R:M105	R:R:S155	7.67	No	No	0	5	7
86	R:R:S107	R:R:W285	3.71	No	Yes	1	7	8
87	L:L:?1	R:R:S107	10.78	Yes	No	1	0	7
88	R:R:S202	R:R:T108	9.59	No	No	0	6	6
89	R:R:A109	R:R:S151	3.42	No	Yes	0	7	8
90	R:R:I111	R:R:P206	3.39	No	No	0	8	9
91	R:R:I111	R:R:W285	3.52	No	Yes	0	8	8
92	R:R:F281	R:R:L114	4.87	Yes	No	0	9	9
93	R:R:L114	R:R:Y331	3.52	No	Yes	0	9	9
94	R:R:C115	R:R:P206	7.53	No	No	0	7	9
95	R:R:C115	R:R:I209	6.55	No	No	0	7	6
96	R:R:I117	R:R:Y331	3.63	No	Yes	0	9	9
97	R:R:M210	R:R:S118	4.6	No	No	0	8	8
98	R:R:S118	R:R:T213	6.4	No	No	0	8	7
99	R:R:S118	R:R:Y214	13.99	No	Yes	0	8	9
100	R:R:D120	R:R:Y131	4.6	No	Yes	3	9	7
101	R:R:R121	R:R:Y214	7.2	No	Yes	5	9	9
102	R:R:R121	R:R:Y331	6.17	No	Yes	5	9	9
103	R:R:S126	R:R:Y122	15.26	No	No	0	7	8
104	R:R:R216	R:R:Y122	18.52	No	No	0	5	8
105	R:R:M135	R:R:W123	3.49	No	No	0	7	4
106	R:R:A124	R:R:Y131	8.01	No	Yes	0	8	7
107	R:R:R130	R:R:S127	13.18	No	No	0	5	6
108	R:R:E132	R:R:F129	8.16	No	No	0	5	7
109	R:R:K134	R:R:R130	16.09	No	No	0	5	5
110	R:R:M135	R:R:Y131	5.99	No	Yes	0	7	7
111	R:R:K134	R:R:R133	8.66	No	No	0	5	4
112	R:R:P137	R:R:T136	6.99	No	No	0	1	8
113	R:R:I142	R:R:K138	4.36	No	No	0	1	4
114	R:R:I142	R:R:S145	3.1	No	No	0	1	4
115	R:R:I201	R:R:L150	5.71	No	No	0	4	4
116	R:R:S151	R:R:V152	3.23	Yes	No	0	8	4
117	R:R:I157	R:R:P158	3.39	No	No	0	6	6
118	R:R:P158	R:R:Y194	4.17	No	Yes	0	6	7
119	R:R:H164	R:R:V159	5.54	Yes	No	0	5	5
120	R:R:L161	R:R:W163	6.83	No	No	0	4	6
121	R:R:H164	R:R:K165	5.24	Yes	No	0	5	3
122	R:R:H164	R:R:L190	9	Yes	No	4	5	4
123	R:R:H164	R:R:Y194	4.36	Yes	Yes	4	5	7
124	R:R:D187	R:R:K165	8.3	No	No	0	5	3
125	R:R:D187	R:R:S189	8.83	No	No	0	5	4
126	R:R:L190	R:R:Y194	5.86	No	Yes	4	4	7
127	R:R:S191	R:R:Y194	3.82	No	Yes	0	5	7
128	R:R:F297	R:R:R192	6.41	No	No	0	6	4
129	R:R:S197	R:R:Y194	3.82	No	Yes	0	4	7
130	R:R:S198	R:R:Y194	10.17	No	Yes	0	7	7
131	R:R:I196	R:R:S199	3.1	No	No	0	6	7
132	L:L:?1	R:R:S198	9.43	Yes	No	0	0	7
133	R:R:C293	R:R:S199	3.44	No	No	0	6	7
134	L:L:?1	R:R:S202	4.04	Yes	No	0	0	6
135	R:R:F203	R:R:Y204	8.25	Yes	No	0	8	5
136	R:R:F203	R:R:V207	11.8	Yes	No	0	8	7
137	R:R:F203	R:R:L286	4.87	Yes	Yes	0	8	6
138	R:R:F203	R:R:F289	20.36	Yes	Yes	0	8	7
139	R:R:C293	R:R:Y204	5.38	No	No	0	6	5
140	R:R:I205	R:R:P206	5.08	No	No	0	5	9
141	R:R:F281	R:R:V207	3.93	Yes	No	0	9	7
142	R:R:M210	R:R:M278	4.33	No	No	0	8	8
143	R:R:F281	R:R:M210	7.46	Yes	No	0	9	8
144	R:R:I211	R:R:M278	4.37	No	No	0	6	8
145	R:R:L274	R:R:Y214	4.69	No	Yes	0	8	9
146	R:R:I277	R:R:Y214	6.04	No	Yes	0	8	9
147	R:R:Y214	R:R:Y331	3.97	Yes	Yes	5	9	9
148	R:R:Q222	R:R:Y218	6.76	No	Yes	0	6	7
149	R:R:L271	R:R:Y218	4.69	No	Yes	0	7	7
150	R:R:A221	R:R:V270	3.39	No	No	0	9	8
151	R:R:Q222	R:R:R226	16.35	No	No	0	6	5
152	R:R:E267	R:R:Q222	3.82	No	No	0	8	6
153	R:R:K223	R:R:R227	4.95	No	No	0	5	5
154	R:R:E267	R:R:I225	5.47	No	No	0	8	5
155	R:R:E232	R:R:I228	4.1	No	No	0	3	7
156	R:R:E232	R:R:R266	3.49	No	No	0	3	6
157	R:R:I277	R:R:I330	4.42	No	No	0	8	8
158	R:R:F281	R:R:W285	5.01	Yes	Yes	1	9	8
159	R:R:F281	R:R:N323	4.83	Yes	Yes	1	9	9
160	R:R:L286	R:R:V282	4.47	Yes	No	0	6	7
161	R:R:C284	R:R:N323	6.3	No	Yes	0	9	9
162	R:R:F288	R:R:W285	7.02	Yes	Yes	1	7	8
163	R:R:F289	R:R:W285	5.01	Yes	Yes	1	7	8
164	R:R:G320	R:R:W285	8.44	No	Yes	0	7	8
165	R:R:N323	R:R:W285	9.04	Yes	Yes	1	9	8
166	R:R:L286	R:R:P287	4.93	Yes	No	0	6	9
167	R:R:F288	R:R:F289	9.65	Yes	Yes	1	7	7
168	R:R:F288	R:R:N292	9.67	Yes	No	1	7	6
169	R:R:F288	R:R:F313	7.5	Yes	Yes	1	7	4
170	R:R:F288	R:R:V317	3.93	Yes	No	0	7	6
171	L:L:?1	R:R:F288	6.56	Yes	Yes	1	0	7
172	L:L:?1	R:R:F289	5.46	Yes	Yes	1	0	7
173	R:R:F313	R:R:L291	3.65	Yes	Yes	0	4	5
174	R:R:F316	R:R:L291	6.09	No	Yes	0	5	5
175	R:R:F313	R:R:N292	3.62	Yes	No	1	4	6
176	L:L:?1	R:R:N292	9.86	Yes	No	1	0	6
177	R:R:L295	R:R:P296	8.21	No	No	0	3	5
178	R:R:F313	R:R:L295	3.65	Yes	No	0	4	3
179	R:R:C298	R:R:F306	4.19	No	No	0	4	1
180	R:R:I308	R:R:T312	6.08	No	No	0	4	4
181	R:R:D314	R:R:W318	7.82	No	Yes	0	4	5
182	R:R:F316	R:R:V315	3.93	No	No	0	5	4
183	R:R:V317	R:R:W321	8.58	No	Yes	0	6	7
184	R:R:W318	R:R:W321	14.06	Yes	Yes	1	5	7
185	L:L:?1	R:R:W321	3.07	Yes	Yes	1	0	7
186	R:R:N323	R:R:N327	12.26	Yes	No	0	9	9
187	R:R:F333	R:R:I329	3.77	No	No	0	8	7
188	R:R:I330	R:R:Y331	7.25	No	Yes	0	8	9
189	R:R:A332	R:R:F337	8.32	No	No	0	6	9
190	R:R:F333	R:R:R338	4.28	No	No	0	8	8
191	R:R:F333	R:R:F341	4.29	No	Yes	0	8	7
192	R:R:D336	R:R:N334	5.39	No	No	0	7	8
193	R:R:F337	R:R:N334	7.25	No	No	0	9	8
194	R:R:F337	R:R:F341	8.57	No	Yes	0	9	7
195	R:R:S342	R:R:T343	3.2	No	No	0	5	4
196	R:R:A229	R:R:E232	3.02	No	No	0	4	3
197	R:R:K138	R:R:T136	3	No	No	0	4	8
198	R:R:L76	R:R:V75	2.98	No	No	0	6	5
199	R:R:L30	R:R:T26	2.95	No	No	0	7	5
200	R:R:L71	R:R:T42	2.95	No	No	0	8	5
201	R:R:L112	R:R:T108	2.95	No	No	0	5	6
202	R:R:I125	R:R:I217	2.94	No	No	0	8	9
203	R:R:I125	R:R:I220	2.94	No	No	0	8	6
204	R:R:I34	R:R:M78	2.92	No	Yes	0	6	7
205	R:R:F61	R:R:P137	2.89	Yes	No	0	4	1
206	R:R:F89	R:R:P91	2.89	No	No	0	4	1
207	R:R:Q160	R:R:V159	2.87	No	No	0	5	5
208	R:R:I154	R:R:L153	2.85	No	No	0	5	4
209	R:R:I157	R:R:L161	2.85	No	No	0	6	4
210	R:R:I290	R:R:L286	2.85	No	Yes	0	7	6
211	R:R:I294	R:R:L291	2.85	No	Yes	0	5	5
212	R:R:C307	R:R:F306	2.79	No	No	0	3	1
213	R:R:A47	R:R:F341	2.77	No	Yes	0	8	7
214	R:R:A340	R:R:F51	2.77	No	Yes	0	7	6
215	R:R:A140	R:R:F61	2.77	No	Yes	0	7	4
216	R:R:A140	R:R:F62	2.77	No	Yes	0	7	8
217	R:R:A335	R:R:R338	2.77	No	No	0	5	8
218	R:R:D336	R:R:K339	2.77	No	No	0	7	5
219	R:R:F341	R:R:V44	2.62	Yes	No	0	7	9
220	R:R:R216	R:R:V212	2.62	No	No	0	5	4
221	R:R:A82	R:R:W318	2.59	No	Yes	0	6	5
222	R:R:R219	R:R:T215	2.59	No	No	0	4	3
223	R:R:H164	R:R:N97	2.55	Yes	No	0	5	6
224	R:R:V270	R:R:Y218	2.52	No	Yes	0	8	7
225	R:R:F95	R:R:I98	2.51	No	No	0	5	6
226	R:R:F102	R:R:I98	2.51	No	No	0	5	6
227	R:R:I225	R:R:R266	2.51	No	No	0	5	6
228	R:R:T213	R:R:Y122	2.5	No	No	0	7	8
229	R:R:S151	R:R:W148	2.47	Yes	No	0	8	9
230	R:R:V68	R:R:W148	2.45	No	No	0	6	9
231	R:R:V119	R:R:W123	2.45	No	No	0	6	4
232	R:R:F29	R:R:L33	2.44	No	No	0	3	7
233	R:R:I217	R:R:Y214	2.42	No	Yes	0	9	9
234	R:R:L274	R:R:Y218	2.34	No	Yes	0	8	7
235	R:R:Q224	R:R:R227	2.34	No	No	0	7	5
236	R:R:F51	R:R:R50	2.14	Yes	No	0	6	6
237	R:R:G40	R:R:P328	2.03	No	No	0	9	9
238	R:R:A195	R:R:P296	1.87	No	No	0	5	5
239	R:R:G279	R:R:V282	1.84	No	No	0	5	7
240	R:R:A322	R:R:C284	1.81	No	No	0	4	9
241	R:R:P128	R:R:S127	1.78	No	No	0	8	6
242	R:R:P328	R:R:V44	1.77	No	No	0	9	9
243	R:R:G40	R:R:L39	1.71	No	No	0	9	4
244	R:R:G40	R:R:L43	1.71	No	No	0	9	7
245	R:R:A332	R:R:V63	1.7	No	No	0	6	8
246	R:R:C45	R:R:T42	1.69	No	No	0	7	5
247	R:R:A139	R:R:T136	1.68	No	No	0	6	8
248	R:R:S126	R:R:S127	1.63	No	No	0	7	6
249	R:R:A27	R:R:I24	1.62	No	No	0	6	6
250	R:R:S145	R:R:V146	1.62	No	No	0	4	3
251	R:R:S191	R:R:T193	1.6	No	No	0	5	4
252	R:R:T26	R:R:V22	1.59	No	No	0	5	4
253	R:R:T149	R:R:V152	1.59	No	No	0	3	4
254	R:R:A147	R:R:L112	1.58	No	No	0	7	5
255	R:R:I205	R:R:V200	1.54	No	No	0	5	4
256	R:R:I330	R:R:V276	1.54	No	No	0	8	7
257	R:R:K272	R:R:V276	1.52	No	No	0	7	7
258	R:R:I277	R:R:T273	1.52	No	No	0	8	9
259	R:R:F319	R:R:G320	1.51	No	No	0	7	7
260	R:R:L143	R:R:V116	1.49	No	No	0	7	7
261	R:R:L326	R:R:V280	1.49	No	No	0	6	7
262	R:R:N311	R:R:S310	1.49	No	No	0	1	1
263	R:R:I154	R:R:I201	1.47	No	No	0	5	4
264	R:R:D309	R:R:S310	1.47	No	No	0	4	1
265	R:R:D309	R:R:T312	1.45	No	No	0	4	4
266	R:R:P296	R:R:R192	1.44	No	No	0	5	4
267	R:R:I308	R:R:L291	1.43	No	Yes	0	4	5
268	R:R:L35	R:R:L38	1.38	No	No	0	5	7
269	R:R:L71	R:R:L72	1.38	No	No	0	8	7
270	R:R:F92	R:R:V83	1.31	No	No	0	6	4
271	R:R:F61	R:R:I64	1.26	Yes	No	0	4	6
272	R:R:F141	R:R:I144	1.26	No	No	0	3	8
273	R:R:E267	R:R:F264	1.17	No	No	0	8	5
274	R:R:R219	R:R:Y218	1.03	No	Yes	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F51	4.78667	6	2	6
2	R:R:F61	3.04	4	0	4
3	R:R:F62	4.41	4	0	8
4	R:R:L66	5.2025	4	0	9
5	R:R:D70	7.9625	4	0	9
6	R:R:M78	5.658	5	1	7
7	R:R:W90	7.83333	6	1	8
8	R:R:W99	5.5	5	1	5
9	R:R:D103	6.516	5	1	7
10	R:R:Y131	5.5875	4	3	7
11	R:R:S151	3.0475	4	0	8
12	R:R:H164	5.338	5	4	5
13	R:R:Y194	5.80857	7	4	7
14	R:R:F203	11.32	4	0	8
15	R:R:Y214	6.385	6	5	9
16	R:R:Y218	3.468	5	0	7
17	R:R:F281	5.22	5	1	9
18	R:R:W285	5.96429	7	1	8
19	R:R:L286	4.28	4	0	6
20	R:R:F288	7.38833	6	1	7
21	R:R:F289	10.12	4	1	7
22	R:R:L291	3.505	4	0	5
23	R:R:F313	4.605	4	1	4
24	R:R:W318	8.112	5	1	5
25	R:R:W321	7.15429	7	1	7
26	R:R:N323	8.1075	4	1	9
27	R:R:Y331	4.908	5	5	9
28	R:R:F341	4.5625	4	0	7
29	L:L:?1	8.94667	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L30	R:R:T26	10.7241	2.95	No	No	0	7	5
2	R:R:L30	R:R:W318	17.0838	9.11	No	Yes	0	7	5
3	R:R:M78	R:R:T37	15.9313	4.52	Yes	No	0	7	7
4	R:R:D70	R:R:S324	20.7107	5.89	Yes	No	0	9	9
5	R:R:S324	R:R:V73	20.7298	6.46	No	No	0	9	8
6	R:R:M78	R:R:V73	26.0232	4.56	Yes	No	0	7	8
7	R:R:D70	R:R:N41	39.7772	13.46	Yes	No	0	9	9
8	R:R:N41	R:R:P328	38.4426	8.15	No	No	0	9	9
9	R:R:P328	R:R:V44	31.6742	1.77	No	No	0	9	9
10	R:R:D70	R:R:N327	40.3806	8.08	Yes	No	0	9	9
11	R:R:L66	R:R:N327	37.0059	4.12	Yes	No	0	9	9
12	R:R:I117	R:R:L66	45.99	4.28	No	Yes	0	9	9
13	R:R:F62	R:R:I117	59.099	3.77	Yes	No	0	8	9
14	R:R:A140	R:R:F62	32.1276	2.77	No	Yes	0	7	8
15	R:R:A140	R:R:F61	29.8768	2.77	No	Yes	0	7	4
16	R:R:F341	R:R:V44	28.9222	2.62	Yes	No	0	7	9
17	R:R:F337	R:R:F341	20.5127	8.57	No	Yes	0	9	7
18	R:R:F337	R:R:N334	16.2218	7.25	No	No	0	9	8
19	R:R:D336	R:R:N334	14.7787	5.39	No	No	0	7	8
20	R:R:D336	R:R:L54	11.8734	4.07	No	No	0	7	9
21	R:R:D120	R:R:F62	20.7139	7.17	No	Yes	0	9	8
22	R:R:D120	R:R:Y131	11.4361	4.6	No	Yes	3	9	7
23	R:R:W318	R:R:W321	21.0236	14.06	Yes	Yes	1	5	7
24	R:R:D103	R:R:W321	11.3275	5.58	Yes	Yes	1	7	7
25	R:R:D103	R:R:S107	21.2343	4.42	Yes	No	1	7	7
26	R:R:S107	R:R:W285	55.9862	3.71	No	Yes	1	7	8
27	R:R:F281	R:R:W285	100	5.01	Yes	Yes	1	9	8
28	R:R:F281	R:R:L114	68.5748	4.87	Yes	No	0	9	9
29	L:L:?1	R:R:W321	36.8846	3.07	Yes	Yes	1	0	7
30	L:L:?1	R:R:S107	34.6083	10.78	Yes	No	1	0	7
31	R:R:F288	R:R:V317	10.0441	3.93	Yes	No	0	7	6
32	R:R:F288	R:R:W285	53.1543	7.02	Yes	Yes	1	7	8
33	L:L:?1	R:R:F288	39.6048	6.56	Yes	Yes	1	0	7
34	L:L:?1	R:R:F289	38.1681	5.46	Yes	Yes	1	0	7
35	R:R:F289	R:R:W285	36.361	5.01	Yes	Yes	1	7	8
36	R:R:C106	R:R:V73	11.8543	3.42	No	No	0	7	8
37	R:R:C96	R:R:W90	21.164	10.45	No	Yes	1	9	8
38	R:R:C96	R:R:W99	24.3726	3.92	No	Yes	1	9	5
39	R:R:K81	R:R:W321	10.4463	5.8	No	Yes	0	6	7
40	R:R:D103	R:R:W99	21.6397	3.35	Yes	Yes	1	7	5
41	L:L:?1	R:R:I104	45.4984	17.93	Yes	No	0	0	6
42	R:R:H164	R:R:V159	14.5265	5.54	Yes	No	0	5	5
43	R:R:H164	R:R:Y194	38.5895	4.36	Yes	Yes	4	5	7
44	R:R:I104	R:R:Y194	40.818	8.46	No	Yes	0	6	7
45	R:R:S198	R:R:Y194	40.7637	10.17	No	Yes	0	7	7
46	L:L:?1	R:R:S198	43.1039	9.43	Yes	No	0	0	7
47	R:R:I111	R:R:W285	10.6475	3.52	No	Yes	0	8	8
48	R:R:L114	R:R:Y331	52.8415	3.52	No	Yes	0	9	9
49	R:R:F281	R:R:M210	39.4707	7.46	Yes	No	0	9	8
50	R:R:M210	R:R:S118	36.013	4.6	No	No	0	8	8
51	R:R:S118	R:R:T213	14.1402	6.4	No	No	0	8	7
52	R:R:Y214	R:R:Y331	34.902	3.97	Yes	Yes	5	9	9
53	R:R:S118	R:R:Y214	25.2666	13.99	No	Yes	0	8	9
54	R:R:T213	R:R:Y122	12.7546	2.5	No	No	0	7	8
55	R:R:F61	R:R:P137	16.4006	2.89	Yes	No	0	4	1
56	R:R:P137	R:R:T136	14.0764	6.99	No	No	0	1	8
57	R:R:P158	R:R:Y194	19.357	4.17	No	Yes	0	6	7
58	R:R:I157	R:R:P158	14.5265	3.39	No	No	0	6	6
59	R:R:H164	R:R:K165	14.5265	5.24	Yes	No	0	5	3
60	R:R:F288	R:R:F313	17.3808	7.5	Yes	Yes	1	7	4
61	R:R:L274	R:R:Y214	41.5778	4.69	No	Yes	0	8	9
62	R:R:L274	R:R:Y218	39.0269	2.34	No	Yes	0	8	7
63	R:R:Q222	R:R:Y218	23.5873	6.76	No	Yes	0	6	7
64	R:R:E267	R:R:Q222	18.3896	3.82	No	No	0	8	6
65	R:R:E267	R:R:I225	13.1665	5.47	No	No	0	8	5
66	R:R:I225	R:R:R266	10.5453	2.51	No	No	0	5	6
67	R:R:N323	R:R:W285	41.4469	9.04	Yes	Yes	1	9	8
68	R:R:F313	R:R:L291	13.5879	3.65	Yes	Yes	0	4	5
69	R:R:L114	R:R:L66	26.8118	5.54	No	Yes	0	9	9
70	R:R:M78	R:R:W321	34.9786	9.31	Yes	Yes	1	7	7
71	R:R:I117	R:R:Y331	26.9395	3.63	No	Yes	0	9	9
72	R:R:N323	R:R:N327	42.7782	12.26	Yes	No	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V77	R:R:W99	3.68	1	No	Yes	8	5	2	2
R:R:D103	R:R:V77	5.84	1	Yes	No	7	8	1	2
R:R:V77	R:R:W321	3.68	1	No	Yes	8	7	2	1
R:R:M78	R:R:W318	6.98	1	Yes	Yes	7	5	2	2
R:R:M78	R:R:W321	9.31	1	Yes	Yes	7	7	2	1
R:R:K81	R:R:W99	8.12	0	No	Yes	6	5	2	2
R:R:K81	R:R:W321	5.8	0	No	Yes	6	7	2	1
R:R:D103	R:R:W99	3.35	1	Yes	Yes	7	5	1	2
R:R:I104	R:R:V100	3.07	0	No	No	6	5	1	2
R:R:D103	R:R:S107	4.42	1	Yes	No	7	7	1	1
R:R:D103	R:R:W321	5.58	1	Yes	Yes	7	7	1	1
L:L:?1	R:R:D103	13.39	1	Yes	Yes	0	7	0	1
R:R:I104	R:R:Y194	8.46	0	No	Yes	6	7	1	2
L:L:?1	R:R:I104	17.93	1	Yes	No	0	6	0	1
R:R:S107	R:R:W285	3.71	1	No	Yes	7	8	1	2
L:L:?1	R:R:S107	10.78	1	Yes	No	0	7	0	1
R:R:S202	R:R:T108	9.59	0	No	No	6	6	1	2
R:R:S198	R:R:Y194	10.17	0	No	Yes	7	7	1	2
L:L:?1	R:R:S198	9.43	1	Yes	No	0	7	0	1
L:L:?1	R:R:S202	4.04	1	Yes	No	0	6	0	1
R:R:F203	R:R:F289	20.36	0	Yes	Yes	8	7	2	1
R:R:F288	R:R:W285	7.02	1	Yes	Yes	7	8	1	2
R:R:F289	R:R:W285	5.01	1	Yes	Yes	7	8	1	2
R:R:F288	R:R:F289	9.65	1	Yes	Yes	7	7	1	1
R:R:F288	R:R:N292	9.67	1	Yes	No	7	6	1	1
R:R:F288	R:R:F313	7.5	1	Yes	Yes	7	4	1	2
R:R:F288	R:R:V317	3.93	1	Yes	No	7	6	1	2
L:L:?1	R:R:F288	6.56	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F289	5.46	1	Yes	Yes	0	7	0	1
R:R:F313	R:R:N292	3.62	1	Yes	No	4	6	2	1
L:L:?1	R:R:N292	9.86	1	Yes	No	0	6	0	1
R:R:V317	R:R:W321	8.58	0	No	Yes	6	7	2	1
R:R:W318	R:R:W321	14.06	1	Yes	Yes	5	7	2	1
L:L:?1	R:R:W321	3.07	1	Yes	Yes	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F24_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	252
Number of Links	274
Number of Hubs	29
Number of Links mediated by Hubs	125
Number of Communities	5
Number of Nodes involved in Communities	32
Number of Links involved in Communities	44

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	76022
Length Of Smallest Path	3
Average Path Length	12.5169
Length of Longest Path	25
Minimum Path Strength	1.46
Average Path Strength	6.02097
Maximum Path Strength	16.89
Minimum Path Correlation	0.94
Average Path Correlation	0.999308
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	100
Average % Of Corr. Nodes	100
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.2308
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • system process • regulation of biological process • nervous system process • neuromuscular process • regulation of system process • biological regulation • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • arrestin family protein binding • neurotransmitter receptor activity • dopamine neurotransmitter receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • dopamine neurotransmitter receptor activity, coupled via Gs • cation binding • ion binding • catecholamine binding • dopamine binding • small molecule binding • G-protein alpha-subunit binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • heterotrimeric G-protein binding • response to xenobiotic stimulus • behavior • learning • learning or memory • feeding behavior • cognition • associative learning • conditioned taste aversion • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • reproductive process • multicellular organismal reproductive process • reproductive behavior • mating behavior • nonassociative learning • habituation • memory • establishment of protein localization • cellular localization • nucleocytoplasmic transport • transport • nuclear transport • intracellular transport • protein localization to nucleus • establishment of localization • localization • import into nucleus • establishment of protein localization to organelle • protein transport • establishment of localization in cell • macromolecule localization • protein localization to organelle • protein import into nucleus • intracellular protein localization • intracellular protein transport • cellular developmental process • forebrain development • central nervous system neuron development • cell development • substrate-independent telencephalic tangential migration • cerebral cortex GABAergic interneuron differentiation • interneuron migration • neurogenesis • central nervous system neuron differentiation • telencephalon cell migration • forebrain cell migration • neuron differentiation • cell differentiation • substrate-independent telencephalic tangential interneuron migration • cerebral cortex GABAergic interneuron migration • cell migration • cell motility • GABAergic neuron differentiation • head development • interneuron migration from the subpallium to the cortex • neuron migration • forebrain generation of neurons • brain development • nervous system development • cerebral cortex GABAergic interneuron development • generation of neurons • forebrain neuron development • central nervous system development • neuron development • telencephalon development • cerebral cortex neuron differentiation • forebrain neuron differentiation • astrocyte differentiation • glial cell development • astrocyte development • gliogenesis • glial cell differentiation • regulation of localization • regulation of potassium ion transport • regulation of transport • regulation of monoatomic ion transport • positive regulation of biological process • metal ion transport • positive regulation of potassium ion transport • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • potassium ion transport • monoatomic cation transport • regulation of metal ion transport • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • transmission of nerve impulse • striatum development • subpallium development • adult walking behavior • adult locomotory behavior • adult behavior • locomotory behavior • walking behavior • cellular component organization • cellular component biogenesis • cell junction organization • cellular component assembly • cell junction assembly • synapse organization • cellular component organization or biogenesis • synapse assembly • phospholipase C-activating dopamine receptor signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • peristalsis • muscle system process • modification of postsynaptic structure • modification of synaptic structure • behavioral response to cocaine • response to cocaine • response to alkaloid • positive regulation of cell communication • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • positive regulation of cellular process • positive regulation of synaptic transmission • positive regulation of synaptic transmission, glutamatergic • positive regulation of signaling • maternal behavior • parental behavior • sensitization • positive regulation of locomotion • regulation of cell motility • regulation of neuron migration • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • locomotion • regulation of locomotion • positive regulation of neuron migration • monoamine transport • import into cell • nitrogen compound transport • organic hydroxy compound transport • dopamine transport • catecholamine uptake • dopamine uptake involved in synaptic transmission • catecholamine transport • regulation of dopamine uptake involved in synaptic transmission • neurotransmitter reuptake • regulation of neurotransmitter uptake • regulation of neurotransmitter transport • neurotransmitter transport • neurotransmitter uptake • synaptic transmission, dopaminergic • dopamine uptake • response to light stimulus • visual learning • visual behavior • response to radiation • response to abiotic stimulus • action potential • neuronal action potential • regulation of biological quality • regulation of membrane potential • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • dentate gyrus development • pallium development • hippocampus development • limbic system development • multicellular organismal-level homeostasis • homeostatic process • temperature homeostasis • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • monoatomic ion transmembrane transport • regulation of monoatomic ion transmembrane transport • calcium ion transport • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • positive regulation of monoatomic ion transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • calcium ion transmembrane import into cytosol • regulation of release of sequestered calcium ion into cytosol • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • response to amine • response to amphetamine • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • negative regulation of signaling • negative regulation of biological process • negative regulation of synaptic transmission • negative regulation of cell communication • negative regulation of cellular process • regulation of synaptic plasticity • long-term synaptic depression • operant conditioning • long-term synaptic potentiation • grooming behavior • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • plasma membrane signaling receptor complex • G protein-coupled receptor complex • receptor complex • presynapse • presynaptic membrane • glutamatergic synapse • neuron spine • dendritic spine • somatodendritic compartment • dendrite • dendritic tree • GABA-ergic synapse • ciliary membrane • cell projection membrane • endoplasmic reticulum subcompartment • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • endoplasmic reticulum membrane • nucleus
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	GTP
PDB Residues	O:O:?1
Environment Details	Open EMBL-EBI Page
Code	GTP
Name	Guanosine-5'-Triphosphate
Synonyms	Guanosine-5'-Triphosphate
Identifier
Formula	C10 H16 N5 O14 P3
Molecular Weight	523.18
SMILES
PubChem	5280317
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	4
Total Bonds	50
Total Aromatic Bonds	5


Code	LDP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	LDP
Name	Dopamine
Synonyms	Oxytyramine
Identifier
Formula	C8 H11 N O2
Molecular Weight	153.178
SMILES
PubChem	681
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	0
Total Bonds	22
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21728
Sequence	>7F24_nogp_Chain_R F S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F R H L R S K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G F W P F G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S P F R Y E R K M T P K A A F I L I S V A W T L S V L I S F I P V Q L S W H K A N C D S S L S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C G F C I D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F R K A F S T L L G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4NTJ	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	AZD1283	-	-	2.62	2014-03-26	doi.org/10.1038/nature13083
	7AD3	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	Gi1/STE4/γ2	3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7AD3 (No Gprot)	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-		3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7JV5	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JV5 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7CKW	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKW (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-		3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-	Gs/β1/γ2	3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-		3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-	Gs/β1/γ2	3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-		3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKZ	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7LJC	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	Mevidalen	Gs/β1/γ2	3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJC (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	Mevidalen		3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ1	3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7CMV	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-	Gi1/β1/γ2	2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7CMV (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-		2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7JOZ	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 75202022	-	Gs/β1/γ2	3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7JOZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 75202022	-		3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7QA8	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	Antagonist Peptide	-	-	2.7	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QB9	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	-	-	-	3.1	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBC	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.53	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBI	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.46	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7F0T	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-	Gs/β1/γ2	3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F0T (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-		3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1O	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg	Gs/β1/γ2	3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1O (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg		3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7X2D	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-	Gs/β1/γ2	3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2D (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-		3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2F	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2F (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2C	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam	Gs/β1/γ2	3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7X2C (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam		3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7W41	A	Peptide	Bombesin	BB₂	Homo sapiens	PD176252	-	-	2.95	2023-02-22	doi.org/10.1073/pnas.2216230120
	8IRR	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-	Gs/β1/γ2	3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8IRR (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-		3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8JD1	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	-	-	3.7	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8JXR	A	Amine	Dopamine	D₁	Homo sapiens	LSD	-	-	3.57	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8JXS	A	Amine	Dopamine	D₁	Homo sapiens	PF-6142	-	-	3	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JF4	A	Peptide	Bombesin	BB₁	Homo sapiens	PD168368	-	-	3.6	2025-07-09	To be published
	9I52	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-	Gs/β1/γ2	2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I52 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-		2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 176452091	-	Gs/β1/γ2	2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 176452091	-		2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9V0U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9V0U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.