psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I86	R:R:R23	3.76	No	No	0	5	5
2	R:R:F29	R:R:L25	7.31	No	No	0	3	4
3	R:R:E85	R:R:L30	3.98	No	No	1	4	7
4	R:R:L30	R:R:W318	7.97	No	Yes	1	7	5
5	R:R:I34	R:R:M78	4.37	No	Yes	0	6	7
6	R:R:S325	R:R:S36	4.89	No	No	0	6	4
7	R:R:A74	R:R:T37	3.36	No	Yes	0	7	7
8	R:R:M78	R:R:T37	9.03	Yes	Yes	0	7	7
9	R:R:S324	R:R:T37	3.2	No	Yes	0	9	7
10	R:R:S325	R:R:T37	4.8	No	Yes	0	6	7
11	R:R:A74	R:R:L38	3.15	No	No	0	7	7
12	R:R:L39	R:R:L43	4.15	No	No	0	4	7
13	R:R:D70	R:R:N41	6.73	Yes	No	0	9	9
14	R:R:L71	R:R:N41	6.87	No	No	0	8	9
15	R:R:N41	R:R:P328	4.89	No	No	0	9	9
16	R:R:A67	R:R:V44	3.39	No	Yes	0	9	9
17	R:R:A46	R:R:L344	3.15	No	Yes	0	5	6
18	R:R:L54	R:R:V48	4.47	Yes	No	0	9	8
19	R:R:F51	R:R:H53	10.18	No	No	0	6	6
20	R:R:R52	R:R:R55	7.46	No	No	0	7	8
21	R:R:H53	R:R:L54	6.43	No	Yes	0	6	9
22	R:R:F337	R:R:L54	3.65	Yes	Yes	0	9	9
23	R:R:A340	R:R:L54	3.15	No	Yes	0	7	9
24	R:R:K57	R:R:N60	4.2	No	No	0	5	9
25	R:R:M135	R:R:V58	4.56	No	No	0	7	6
26	R:R:D120	R:R:T59	7.23	No	No	5	9	8
27	R:R:T59	R:R:Y131	3.75	No	Yes	5	8	7
28	R:R:F337	R:R:N60	4.83	Yes	No	0	9	9
29	R:R:F62	R:R:V116	7.87	Yes	No	0	8	7
30	R:R:D120	R:R:F62	10.75	No	Yes	0	9	8
31	R:R:F62	R:R:L143	6.09	Yes	No	0	8	7
32	R:R:F62	R:R:I144	5.02	Yes	No	0	8	8
33	R:R:N113	R:R:S65	10.43	No	No	4	8	9
34	R:R:I144	R:R:S65	3.1	No	No	0	8	9
35	R:R:S65	R:R:W148	6.18	No	Yes	4	9	9
36	R:R:D70	R:R:L66	5.43	Yes	No	0	9	9
37	R:R:L114	R:R:L66	5.54	No	No	2	9	9
38	R:R:L66	R:R:Y331	3.52	No	Yes	2	9	9
39	R:R:A109	R:R:S69	3.42	No	No	4	7	8
40	R:R:S69	R:R:W148	3.71	No	Yes	4	8	9
41	R:R:D70	R:R:S110	4.42	Yes	No	0	9	9
42	R:R:D70	R:R:S324	10.31	Yes	No	0	9	9
43	R:R:D70	R:R:N327	8.08	Yes	No	0	9	9
44	R:R:M78	R:R:V73	4.56	Yes	No	0	7	8
45	R:R:S324	R:R:V73	3.23	No	No	0	9	8
46	R:R:F102	R:R:L76	6.09	No	No	0	5	6
47	R:R:C106	R:R:V77	3.42	No	No	0	7	8
48	R:R:V77	R:R:W321	4.9	No	Yes	0	8	7
49	R:R:F95	R:R:W80	12.03	No	No	0	5	5
50	R:R:K81	R:R:W99	9.28	Yes	Yes	0	6	5
51	R:R:D314	R:R:K81	4.15	No	Yes	1	4	6
52	R:R:K81	R:R:W318	4.64	Yes	Yes	1	6	5
53	R:R:K81	R:R:W321	5.8	Yes	Yes	1	6	7
54	R:R:D314	R:R:E85	9.09	No	No	1	4	4
55	R:R:E85	R:R:W318	10.9	No	Yes	1	4	5
56	R:R:P91	R:R:W90	8.11	No	Yes	0	1	8
57	R:R:C96	R:R:W90	5.22	No	Yes	6	9	8
58	R:R:W90	R:R:W99	4.69	Yes	Yes	0	8	5
59	R:R:C186	R:R:W90	16.98	No	Yes	6	9	8
60	R:R:F92	R:R:S94	6.61	No	No	0	6	1
61	R:R:F92	R:R:F95	4.29	No	No	0	6	5
62	R:R:D184	R:R:G93	3.35	No	No	0	3	7
63	R:R:F95	R:R:W99	4.01	No	Yes	0	5	5
64	R:R:C186	R:R:C96	7.28	No	No	6	9	9
65	R:R:I98	R:R:Q160	4.12	No	No	0	6	5
66	R:R:D103	R:R:W99	5.58	No	Yes	0	7	5
67	R:R:V100	R:R:V159	4.81	No	No	0	5	5
68	R:R:S188	R:R:V100	3.23	No	No	0	5	5
69	R:R:A101	R:R:F156	4.16	No	Yes	0	6	5
70	R:R:A101	R:R:V159	3.39	No	No	0	6	5
71	R:R:F102	R:R:F156	8.57	No	Yes	0	5	5
72	R:R:D103	R:R:W321	6.7	No	Yes	1	7	7
73	L:L:?1	R:R:D103	10.96	Yes	No	1	0	7
74	R:R:I104	R:R:S155	3.1	No	No	0	6	7
75	R:R:I104	R:R:Y194	7.25	No	Yes	0	6	7
76	R:R:M105	R:R:S155	4.6	No	No	7	5	7
77	R:R:F156	R:R:M105	6.22	Yes	No	7	5	5
78	R:R:S107	R:R:W285	4.94	No	Yes	0	7	8
79	L:L:?1	R:R:S107	8.08	Yes	No	0	0	7
80	R:R:S151	R:R:T108	3.2	No	No	0	8	6
81	R:R:S202	R:R:T108	6.4	No	No	0	6	6
82	R:R:A109	R:R:W148	3.89	No	Yes	4	7	9
83	R:R:A109	R:R:S151	3.42	No	No	0	7	8
84	R:R:I111	R:R:P206	3.39	No	No	0	8	9
85	R:R:F281	R:R:I111	7.54	Yes	No	2	9	8
86	R:R:I111	R:R:W285	11.74	No	Yes	2	8	8
87	R:R:L112	R:R:L150	5.54	No	No	0	5	4
88	R:R:N113	R:R:W148	4.52	No	Yes	4	8	9
89	R:R:F281	R:R:L114	3.65	Yes	No	2	9	9
90	R:R:L114	R:R:Y331	7.03	No	Yes	2	9	9
91	R:R:C115	R:R:P206	3.77	No	No	0	7	9
92	R:R:C115	R:R:I209	6.55	No	No	0	7	6
93	R:R:I117	R:R:R121	6.26	No	No	0	9	9
94	R:R:S118	R:R:T213	7.99	No	No	0	8	7
95	R:R:S118	R:R:Y214	5.09	No	Yes	0	8	9
96	R:R:V119	R:R:W123	8.58	No	No	0	6	4
97	R:R:D120	R:R:Y131	8.05	No	Yes	5	9	7
98	R:R:R121	R:R:Y331	7.2	No	Yes	0	9	9
99	R:R:S126	R:R:Y122	6.36	No	Yes	0	7	8
100	R:R:R216	R:R:Y122	13.38	No	Yes	0	5	8
101	R:R:I217	R:R:Y122	4.84	No	Yes	0	9	8
102	R:R:L143	R:R:W123	3.42	No	No	3	7	4
103	R:R:W123	W:W:?1	44.07	No	Yes	3	4	0
104	R:R:A124	R:R:Y131	8.01	No	Yes	0	8	7
105	R:R:I125	R:R:I220	4.42	No	No	0	8	6
106	R:R:S127	W:W:?1	3.42	No	Yes	0	6	0
107	R:R:K134	R:R:R130	6.19	No	No	3	5	5
108	R:R:R130	W:W:?1	30.42	No	Yes	3	5	0
109	R:R:M135	R:R:Y131	8.38	No	Yes	0	7	7
110	R:R:K134	W:W:?1	9.63	No	Yes	3	5	0
111	R:R:P137	R:R:T136	3.5	No	No	0	1	8
112	R:R:K138	W:W:?1	6.42	No	Yes	0	4	0
113	R:R:A139	W:W:?1	10.76	No	Yes	0	6	0
114	R:R:I142	W:W:?1	8.66	No	Yes	0	1	0
115	R:R:L143	W:W:?1	5.25	No	Yes	3	7	0
116	R:R:I201	R:R:L150	4.28	No	No	0	4	4
117	R:R:F156	R:R:V152	7.87	Yes	No	0	5	4
118	R:R:I154	R:R:S198	6.19	No	No	0	5	7
119	R:R:F156	R:R:S155	5.28	Yes	No	7	5	7
120	R:R:I157	R:R:P158	3.39	No	No	0	6	6
121	R:R:P158	R:R:Y194	9.74	No	Yes	0	6	7
122	R:R:H164	R:R:V159	11.07	Yes	No	0	5	5
123	R:R:L161	R:R:W163	6.83	No	No	0	4	6
124	R:R:H164	R:R:L190	5.14	Yes	No	0	5	4
125	R:R:H164	R:R:Y194	5.44	Yes	Yes	0	5	7
126	R:R:K167	R:R:P168	3.35	No	No	0	2	1
127	R:R:K167	R:R:S189	7.65	No	No	0	2	4
128	R:R:D187	R:R:N185	4.04	No	No	0	5	4
129	R:R:L190	R:R:N292	4.12	No	No	0	4	6
130	R:R:S191	R:R:T193	4.8	No	No	0	5	4
131	R:R:F297	R:R:R192	4.28	No	No	0	6	4
132	R:R:S198	R:R:Y194	8.9	No	Yes	0	7	7
133	R:R:C293	R:R:I196	3.27	No	No	0	6	6
134	L:L:?1	R:R:S198	10.78	Yes	No	0	0	7
135	R:R:F289	R:R:S199	3.96	Yes	No	0	7	7
136	R:R:C293	R:R:S199	3.44	No	No	0	6	7
137	L:L:?1	R:R:S202	5.39	Yes	No	0	0	6
138	R:R:F203	R:R:Y204	8.25	Yes	No	0	8	5
139	R:R:F203	R:R:V207	6.55	Yes	No	0	8	7
140	R:R:F203	R:R:L286	3.65	Yes	No	0	8	6
141	R:R:F203	R:R:F289	22.51	Yes	Yes	0	8	7
142	R:R:C293	R:R:Y204	4.03	No	No	0	6	5
143	R:R:I205	R:R:P206	3.39	No	No	0	5	9
144	R:R:M210	R:R:Y214	4.79	No	Yes	0	8	9
145	R:R:F281	R:R:M210	4.98	Yes	No	0	9	8
146	R:R:R216	R:R:V212	3.92	No	No	0	5	4
147	R:R:L274	R:R:Y214	3.52	No	Yes	0	8	9
148	R:R:M278	R:R:Y214	5.99	No	Yes	0	8	9
149	R:R:L274	R:R:Y218	3.52	No	No	0	8	7
150	R:R:A221	R:R:V270	3.39	No	No	0	9	8
151	R:R:Q222	R:R:R226	5.84	No	No	0	6	5
152	R:R:E267	R:R:Q222	3.82	No	No	0	8	6
153	R:R:I225	R:R:R266	6.26	No	No	0	5	6
154	R:R:E267	R:R:I225	4.1	No	No	0	8	5
155	R:R:I228	R:R:R266	11.27	No	No	0	7	6
156	R:R:F264	R:R:T268	3.89	No	No	0	5	5
157	R:R:I277	R:R:Y331	3.63	No	Yes	0	8	9
158	R:R:I330	R:R:V280	4.61	No	No	0	8	7
159	R:R:F281	R:R:W285	6.01	Yes	Yes	2	9	8
160	R:R:F281	R:R:N323	4.83	Yes	Yes	2	9	9
161	R:R:C284	R:R:N323	11.02	No	Yes	0	9	9
162	R:R:F289	R:R:W285	7.02	Yes	Yes	0	7	8
163	R:R:G320	R:R:W285	8.44	No	Yes	0	7	8
164	R:R:N323	R:R:W285	7.91	Yes	Yes	2	9	8
165	R:R:I290	R:R:L286	4.28	No	No	0	7	6
166	R:R:F316	R:R:P287	5.78	No	No	0	5	9
167	R:R:F288	R:R:F313	6.43	No	No	0	7	4
168	R:R:F288	R:R:V317	3.93	No	No	0	7	6
169	L:L:?1	R:R:F288	10.93	Yes	No	0	0	7
170	L:L:?1	R:R:F289	7.65	Yes	Yes	0	0	7
171	R:R:F316	R:R:L291	4.87	No	No	0	5	5
172	L:L:?1	R:R:N292	6.16	Yes	No	0	0	6
173	R:R:L295	R:R:P296	3.28	No	No	0	3	5
174	R:R:F313	R:R:L295	4.87	No	No	0	4	3
175	R:R:C298	R:R:C307	5.46	No	No	0	4	3
176	R:R:C307	R:R:I308	3.27	No	No	0	3	4
177	R:R:D309	R:R:T312	4.34	No	No	0	4	4
178	R:R:D314	R:R:W318	3.35	No	Yes	1	4	5
179	R:R:V317	R:R:W321	8.58	No	Yes	0	6	7
180	R:R:W318	R:R:W321	9.37	Yes	Yes	1	5	7
181	L:L:?1	R:R:W321	5.11	Yes	Yes	1	0	7
182	R:R:N323	R:R:N327	9.54	Yes	No	0	9	9
183	R:R:I329	R:R:L326	4.28	No	No	0	7	6
184	R:R:F333	R:R:I329	6.28	No	No	0	8	7
185	R:R:I330	R:R:Y331	7.25	No	Yes	0	8	9
186	R:R:A332	R:R:F337	6.93	No	Yes	0	6	9
187	R:R:F337	R:R:N334	3.62	Yes	No	0	9	8
188	R:R:F337	R:R:F341	3.22	Yes	No	0	9	7
189	R:R:I64	R:R:V48	3.07	No	No	0	6	8
190	R:R:I205	R:R:V200	3.07	No	No	0	5	4
191	R:R:I211	R:R:V207	3.07	No	No	0	6	7
192	R:R:I225	R:R:V270	3.07	No	No	0	5	8
193	R:R:K167	R:R:S191	3.06	No	No	0	2	5
194	R:R:K138	R:R:T136	3	No	No	0	4	8
195	R:R:L71	R:R:V75	2.98	No	No	0	8	5
196	R:R:L326	R:R:V280	2.98	No	No	0	6	7
197	R:R:L286	R:R:V282	2.98	No	No	0	6	7
198	R:R:N240	R:R:V236	2.96	No	No	0	4	4
199	R:R:L112	R:R:T108	2.95	No	No	0	5	6
200	R:R:I308	R:R:L291	2.85	No	No	0	4	5
201	R:R:G93	R:R:W90	2.81	No	Yes	0	7	8
202	R:R:A47	R:R:F341	2.77	No	No	0	8	7
203	R:R:A87	R:R:F89	2.77	No	No	0	5	4
204	R:R:P158	R:R:W163	2.7	No	No	0	6	6
205	R:R:F341	R:R:V44	2.62	No	Yes	0	7	9
206	R:R:F61	R:R:V58	2.62	No	No	0	4	6
207	R:R:H164	R:R:K165	2.62	Yes	No	0	5	3
208	R:R:F319	R:R:V315	2.62	No	No	0	7	4
209	R:R:F51	R:R:T343	2.59	No	No	0	6	4
210	R:R:A82	R:R:W318	2.59	No	Yes	0	6	5
211	R:R:A84	R:R:W90	2.59	No	Yes	0	5	8
212	R:R:F316	R:R:T312	2.59	No	No	0	5	4
213	R:R:S342	R:R:Y348	2.54	No	No	0	5	3
214	R:R:D336	R:R:H53	2.52	No	No	0	7	6
215	R:R:V270	R:R:Y218	2.52	No	No	0	8	7
216	R:R:F102	R:R:I98	2.51	No	No	0	5	6
217	R:R:F313	R:R:I308	2.51	No	No	0	4	4
218	R:R:T213	R:R:Y122	2.5	No	Yes	0	7	8
219	R:R:V68	R:R:W148	2.45	No	Yes	0	6	9
220	R:R:L344	R:R:R50	2.43	Yes	No	0	6	6
221	R:R:L271	R:R:Y218	2.34	No	No	0	7	7
222	R:R:Q224	R:R:R227	2.34	No	No	0	7	5
223	R:R:E232	R:R:R266	2.33	No	No	0	3	6
224	R:R:L33	R:R:W318	2.28	No	Yes	0	7	5
225	R:R:L72	R:R:W148	2.28	No	Yes	0	7	9
226	R:R:A195	R:R:P296	1.87	No	No	0	5	5
227	R:R:A67	R:R:C45	1.81	No	No	0	9	7
228	R:R:P128	R:R:S127	1.78	No	No	0	8	6
229	R:R:P328	R:R:V44	1.77	No	Yes	0	9	9
230	R:R:G279	R:R:M278	1.75	No	No	0	5	8
231	R:R:G40	R:R:L39	1.71	No	No	0	9	4
232	R:R:A140	R:R:V58	1.7	No	No	0	7	6
233	R:R:A147	R:R:V116	1.7	No	No	0	7	7
234	R:R:M78	R:R:P79	1.68	Yes	No	0	7	8
235	R:R:C298	R:R:I294	1.64	No	No	0	4	5
236	R:R:S21	R:R:V22	1.62	No	No	0	4	4
237	R:R:A27	R:R:I86	1.62	No	No	0	6	5
238	R:R:V44	R:R:V63	1.6	Yes	No	0	9	8
239	R:R:T26	R:R:V22	1.59	No	No	0	5	4
240	R:R:C347	R:R:L345	1.59	No	No	0	9	7
241	R:R:A322	R:R:L33	1.58	No	No	0	4	7
242	R:R:A47	R:R:L344	1.58	No	Yes	0	8	6
243	R:R:A335	R:R:N334	1.56	No	No	0	5	8
244	R:R:I220	R:R:S126	1.55	No	No	0	6	7
245	R:R:I330	R:R:V276	1.54	No	No	0	8	7
246	R:R:K165	R:R:S162	1.53	No	No	0	3	5
247	R:R:I211	R:R:T215	1.52	No	No	0	6	3
248	R:R:K272	R:R:V276	1.52	No	No	0	7	7
249	R:R:I277	R:R:T273	1.52	No	No	0	8	9
250	R:R:L35	R:R:S31	1.5	No	No	0	5	4
251	R:R:K269	R:R:T273	1.5	No	No	0	8	9
252	R:R:L30	R:R:T26	1.47	No	No	0	7	5
253	R:R:L71	R:R:T42	1.47	No	No	0	8	5
254	R:R:F129	R:R:P128	1.44	No	No	0	7	8
255	R:R:P296	R:R:R192	1.44	No	No	0	5	4
256	R:R:I157	R:R:L153	1.43	No	No	0	6	4
257	R:R:I183	R:R:N185	1.42	No	No	0	2	4
258	R:R:K165	R:R:N97	1.4	No	No	0	3	6
259	R:R:H164	R:R:S191	1.39	Yes	No	0	5	5
260	R:R:L35	R:R:L38	1.38	No	No	0	5	7
261	R:R:L344	R:R:L43	1.38	Yes	No	0	6	7
262	R:R:A335	R:R:R338	1.38	No	No	0	5	8
263	R:R:R52	R:R:S56	1.32	No	No	0	7	8
264	R:R:R55	R:R:V48	1.31	No	No	0	8	8
265	R:R:F89	R:R:I183	1.26	No	No	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T37	5.0975	4	0	7
2	R:R:V44	2.345	4	0	9
3	R:R:L54	4.425	4	0	9
4	R:R:F62	7.4325	4	0	8
5	R:R:D70	6.994	5	0	9
6	R:R:M78	4.91	4	0	7
7	R:R:K81	5.9675	4	1	6
8	R:R:W90	6.73333	6	6	8
9	R:R:W99	5.89	4	0	5
10	R:R:Y122	6.77	4	0	8
11	R:R:Y131	7.0475	4	5	7
12	R:R:W148	3.83833	6	4	9
13	R:R:F156	6.42	5	7	5
14	R:R:H164	5.132	5	0	5
15	R:R:Y194	7.8325	4	0	7
16	R:R:F203	10.24	4	0	8
17	R:R:Y214	4.8475	4	0	9
18	R:R:F281	5.402	5	2	9
19	R:R:W285	7.67667	6	2	8
20	R:R:F289	10.285	4	0	7
21	R:R:W318	5.87143	7	1	5
22	R:R:W321	6.74333	6	1	7
23	R:R:N323	8.325	4	2	9
24	R:R:Y331	5.726	5	2	9
25	R:R:F337	4.45	5	0	9
26	R:R:L344	2.135	4	0	6
27	L:L:?1	8.1325	8	1	0
28	W:W:?1	14.8287	8	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:W318	R:R:W321	20.1239	9.37	Yes	Yes	1	5	7
2	L:L:?1	R:R:W321	30.1234	5.11	Yes	Yes	1	0	7
3	L:L:?1	R:R:S107	81.7949	8.08	Yes	No	0	0	7
4	R:R:S107	R:R:W285	81.64	4.94	No	Yes	0	7	8
5	R:R:N323	R:R:W285	92.6226	7.91	Yes	Yes	2	9	8
6	R:R:N323	R:R:N327	100	9.54	Yes	No	0	9	9
7	R:R:D70	R:R:N327	98.5043	8.08	Yes	No	0	9	9
8	R:R:D70	R:R:S324	35.7905	10.31	Yes	No	0	9	9
9	R:R:S324	R:R:T37	23.9139	3.2	No	Yes	0	9	7
10	L:L:?1	R:R:F289	90.4356	7.65	Yes	Yes	0	0	7
11	R:R:F289	R:R:W285	88.5049	7.02	Yes	Yes	0	7	8
12	R:R:D70	R:R:N41	79.6675	6.73	Yes	No	0	9	9
13	R:R:N41	R:R:P328	71.3009	4.89	No	No	0	9	9
14	R:R:P328	R:R:V44	69.1794	1.77	No	Yes	0	9	9
15	R:R:F341	R:R:V44	60.5745	2.62	No	Yes	0	7	9
16	R:R:A47	R:R:F341	17.0967	2.77	No	No	0	8	7
17	R:R:A47	R:R:L344	14.6892	1.58	No	Yes	0	8	6
18	R:R:F337	R:R:F341	42.7924	3.22	Yes	No	0	9	7
19	R:R:F337	R:R:L54	26.6075	3.65	Yes	Yes	0	9	9
20	R:R:L54	R:R:V48	12.2698	4.47	Yes	No	0	9	8
21	L:L:?1	R:R:S202	72.5165	5.39	Yes	No	0	0	6
22	R:R:S202	R:R:T108	70.8778	6.4	No	No	0	6	6
23	R:R:S151	R:R:T108	64.2036	3.2	No	No	0	8	6
24	R:R:A109	R:R:S151	62.5052	3.42	No	No	0	7	8
25	R:R:A109	R:R:W148	58.888	3.89	No	Yes	4	7	9
26	R:R:S65	R:R:W148	51.9814	6.18	No	Yes	4	9	9
27	R:R:I144	R:R:S65	50.3605	3.1	No	No	0	8	9
28	R:R:F62	R:R:I144	48.5668	5.02	Yes	No	0	8	8
29	R:R:D120	R:R:F62	16.3935	10.75	No	Yes	0	9	8
30	R:R:D120	R:R:Y131	12.3294	8.05	No	Yes	5	9	7
31	R:R:F62	R:R:L143	28.0496	6.09	Yes	No	0	8	7
32	R:R:F281	R:R:W285	67.3977	6.01	Yes	Yes	2	9	8
33	R:R:F281	R:R:L114	37.7093	3.65	Yes	No	2	9	9
34	R:R:L114	R:R:L66	12.0791	5.54	No	No	2	9	9
35	R:R:L114	R:R:Y331	24.1642	7.03	No	Yes	2	9	9
36	L:L:?1	R:R:S198	54.8537	10.78	Yes	No	0	0	7
37	R:R:S198	R:R:Y194	51.5166	8.9	No	Yes	0	7	7
38	R:R:I104	R:R:Y194	17.0192	7.25	No	Yes	0	6	7
39	R:R:I104	R:R:S155	15.2077	3.1	No	No	0	6	7
40	R:R:F156	R:R:S155	11.3581	5.28	Yes	No	7	5	7
41	R:R:W90	R:R:W99	14.5105	4.69	Yes	Yes	0	8	5
42	R:R:H164	R:R:Y194	24.6946	5.44	Yes	Yes	0	5	7
43	R:R:H164	R:R:V159	15.5593	11.07	Yes	No	0	5	5
44	L:L:?1	R:R:N292	27.5133	6.16	Yes	No	0	0	6
45	R:R:L190	R:R:N292	25.797	4.12	No	No	0	4	6
46	R:R:H164	R:R:L190	24.1344	5.14	Yes	No	0	5	4
47	R:R:I111	R:R:W285	11.8646	11.74	No	Yes	2	8	8
48	R:R:I111	R:R:P206	14.3257	3.39	No	No	0	8	9
49	R:R:F281	R:R:M210	60.1931	4.98	Yes	No	0	9	8
50	R:R:M210	R:R:Y214	57.9167	4.79	No	Yes	0	8	9
51	R:R:S118	R:R:Y214	22.6268	5.09	No	Yes	0	8	9
52	R:R:S118	R:R:T213	20.1597	7.99	No	No	0	8	7
53	R:R:T213	R:R:Y122	17.6807	2.5	No	Yes	0	7	8
54	R:R:L143	W:W:?1	22.1262	5.25	No	Yes	3	7	0
55	R:R:H164	R:R:S191	19.1228	1.39	Yes	No	0	5	5
56	R:R:K167	R:R:S191	11.5071	3.06	No	No	0	2	5
57	R:R:F288	R:R:F313	31.3688	6.43	No	No	0	7	4
58	R:R:F313	R:R:L295	10.7503	4.87	No	No	0	4	3
59	L:L:?1	R:R:F288	33.6631	10.93	Yes	No	0	0	7
60	R:R:F203	R:R:F289	11.3819	22.51	Yes	Yes	0	8	7
61	R:R:L274	R:R:Y214	29.6705	3.52	No	Yes	0	8	9
62	R:R:L274	R:R:Y218	27.2391	3.52	No	No	0	8	7
63	R:R:V270	R:R:Y218	22.3407	2.52	No	No	0	8	7
64	R:R:I225	R:R:V270	17.3828	3.07	No	No	0	5	8
65	R:R:I330	R:R:Y331	15.5116	7.25	No	Yes	0	8	9
66	R:R:F313	R:R:I308	19.1407	2.51	No	No	0	4	4
67	R:R:I308	R:R:L291	10.7503	2.85	No	No	0	4	5
68	R:R:H164	R:R:K165	11.5071	2.62	Yes	No	0	5	3
69	R:R:D70	R:R:L66	14.6535	5.43	Yes	No	0	9	9
70	R:R:D103	R:R:W99	23.3895	5.58	No	Yes	0	7	5
71	L:L:?1	R:R:D103	24.8674	10.96	Yes	No	1	0	7
72	R:R:F281	R:R:N323	10.6609	4.83	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V77	R:R:W321	4.9	0	No	Yes	8	7	2	1
R:R:K81	R:R:W99	9.28	1	Yes	Yes	6	5	2	2
R:R:K81	R:R:W318	4.64	1	Yes	Yes	6	5	2	2
R:R:K81	R:R:W321	5.8	1	Yes	Yes	6	7	2	1
R:R:D103	R:R:W99	5.58	1	No	Yes	7	5	1	2
R:R:D103	R:R:W321	6.7	1	No	Yes	7	7	1	1
L:L:?1	R:R:D103	10.96	1	Yes	No	0	7	0	1
R:R:S107	R:R:W285	4.94	0	No	Yes	7	8	1	2
L:L:?1	R:R:S107	8.08	1	Yes	No	0	7	0	1
R:R:S202	R:R:T108	6.4	0	No	No	6	6	1	2
R:R:I154	R:R:S198	6.19	0	No	No	5	7	2	1
R:R:L190	R:R:N292	4.12	0	No	No	4	6	2	1
R:R:S198	R:R:Y194	8.9	0	No	Yes	7	7	1	2
L:L:?1	R:R:S198	10.78	1	Yes	No	0	7	0	1
R:R:F289	R:R:S199	3.96	0	Yes	No	7	7	1	2
L:L:?1	R:R:S202	5.39	1	Yes	No	0	6	0	1
R:R:F203	R:R:F289	22.51	0	Yes	Yes	8	7	2	1
R:R:F289	R:R:W285	7.02	0	Yes	Yes	7	8	1	2
R:R:F288	R:R:F313	6.43	0	No	No	7	4	1	2
R:R:F288	R:R:V317	3.93	0	No	No	7	6	1	2
L:L:?1	R:R:F288	10.93	1	Yes	No	0	7	0	1
L:L:?1	R:R:F289	7.65	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N292	6.16	1	Yes	No	0	6	0	1
R:R:V317	R:R:W321	8.58	0	No	Yes	6	7	2	1
R:R:W318	R:R:W321	9.37	1	Yes	Yes	5	7	2	1
L:L:?1	R:R:W321	5.11	1	Yes	Yes	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F62	R:R:L143	6.09	0	Yes	No	8	7	2	1
R:R:V119	R:R:W123	8.58	0	No	No	6	4	2	1
R:R:L143	R:R:W123	3.42	3	No	No	7	4	1	1
R:R:W123	W:W:?1	44.07	3	No	Yes	4	0	1	0
R:R:S127	W:W:?1	3.42	0	No	Yes	6	0	1	0
R:R:K134	R:R:R130	6.19	3	No	No	5	5	1	1
R:R:R130	W:W:?1	30.42	3	No	Yes	5	0	1	0
R:R:K134	W:W:?1	9.63	3	No	Yes	5	0	1	0
R:R:K138	W:W:?1	6.42	0	No	Yes	4	0	1	0
R:R:A139	W:W:?1	10.76	0	No	Yes	6	0	1	0
R:R:I142	W:W:?1	8.66	0	No	Yes	1	0	1	0
R:R:L143	W:W:?1	5.25	3	No	Yes	7	0	1	0
R:R:K138	R:R:T136	3	0	No	No	4	8	1	2
R:R:P128	R:R:S127	1.78	0	No	No	8	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7LJD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.1
Number of Linked Nodes	252
Number of Links	265
Number of Hubs	28
Number of Links mediated by Hubs	122
Number of Communities	7
Number of Nodes involved in Communities	34
Number of Links involved in Communities	42

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	45602
Length Of Smallest Path	3
Average Path Length	13.2231
Length of Longest Path	29
Minimum Path Strength	1.34
Average Path Strength	5.79826
Maximum Path Strength	37.245
Minimum Path Correlation	0.7
Average Path Correlation	0.94523
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	60.0488
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.9602
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	LDP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	LDP
Name	Dopamine
Synonyms	Oxytyramine
Identifier
Formula	C8 H11 N O2
Molecular Weight	153.178
SMILES
PubChem	681
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	0
Total Bonds	22
Total Aromatic Bonds	6


Code	G4C
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	G4C
Name	Mevidalen
Synonyms	Ethanone, 2-(2,6-dichlorophenyl)-1-((1s,3r)-3,4-dihydro-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-2(1h)-isoquinolinyl)- Mevidalen 2-(2,6-dichlorophenyl)-1-((1s,3r)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydroisoquinolin-2(1h)-yl)ethanone
Identifier
Formula	C24 H29 Cl2 N O3
Molecular Weight	450.398
SMILES
PubChem	86290953
Formal Charge	0
Total Atoms	59
Total Chiral Atoms	2
Total Bonds	61
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21728
Sequence	>7LJD_nogp_Chain_R S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F R H L R S K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G F W P F G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S P F R Y E R K M T P K A A F I L I S V A W T L S V L I S F I P V Q L S W H K A K P I D N C D S S L S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C C I D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F R K A F S T L L G C Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4NTJ	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	AZD1283	-	-	2.62	2014-03-26	doi.org/10.1038/nature13083
	7AD3	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	Gi1/STE4/γ2	3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7AD3 (No Gprot)	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-		3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7JV5	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JV5 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVP (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		2.9	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-	Gs/β1/γ2	3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVQ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Apomorphine	-		3	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7CKW	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKW (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	-		3.22	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-	Gs/β1/γ2	3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKX (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A77636	-		3.54	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-	Gs/β1/γ2	3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKY (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PW0464	-		3.2	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKZ	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CKZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.1	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-	Gs/β1/γ2	3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7CRH (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF83959	-		3.3	2021-03-03	doi.org/10.1016/j.cell.2021.01.028
	7LJC	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	Mevidalen	Gs/β1/γ2	3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJC (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	SKF81297	Mevidalen		3	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ1	3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7LJD (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3.2	2021-03-03	doi.org/10.1038/s41422-021-00482-0
	7CMV	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-	Gi1/β1/γ2	2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7CMV (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-		2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7JOZ	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 75202022	-	Gs/β1/γ2	3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7JOZ (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 75202022	-		3.8	2021-04-14	doi.org/10.1038/s41467-021-23519-9
	7TD1	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD1 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.08	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7QA8	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	Antagonist Peptide	-	-	2.7	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QB9	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	-	-	-	3.1	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBC	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.53	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7QBI	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	-	3.46	2022-03-16	doi.org/10.1038/s41586-022-04498-3
	7WU2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ1	2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7WU2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		2.8	2022-04-27	doi.org/10.1038/s41586-022-04580-w
	7EPT	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	Gs/β1/γ2	3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7EPT (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3	2022-05-11	doi.org/10.1038/s41586-022-04619-y
	7F0T	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-	Gs/β1/γ2	3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F0T (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	-		3.1	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1O	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg	Gs/β1/γ2	3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1O (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP; Mg		3.13	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F1Z (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.46	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F23 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		3.58	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP	Gs/β1/γ2	4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7F24 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	GDP		4.16	2022-06-15	doi.org/10.1126/sciadv.abo4158
	7X2D	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-	Gs/β1/γ2	3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2D (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Tavapadon	-		3.3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2F	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen	Gs/β1/γ2	3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2F (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Dopamine	Mevidalen		3	2022-06-15	doi.org/10.1038/s41467-022-30929-w
	7X2C	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam	Gs/β1/γ2	3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7X2C (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Fenoldopam	Fenoldopam		3.2	2022-06-29	doi.org/10.1038/s41467-022-30929-w
	7W41	A	Peptide	Bombesin	BB₂	Homo sapiens	PD176252	-	-	2.95	2023-02-22	doi.org/10.1073/pnas.2216230120
	8IRR	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-	Gs/β1/γ2	3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8IRR (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	Rotigotine	-		3.2	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8JD1	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	-	-	3.7	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8JXR	A	Amine	Dopamine	D₁	Homo sapiens	LSD	-	-	3.57	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8JXS	A	Amine	Dopamine	D₁	Homo sapiens	PF-6142	-	-	3	2024-09-04	doi.org/10.1016/j.neuron.2024.07.003
	8X9S	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9S (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.49	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9T (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	AP503	-		2.75	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-	chim(NtGi1-Gs)/β1/γ2	2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8X9U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	Metenolone	-		2.88	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV1 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		2.98	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JF4	A	Peptide	Bombesin	BB₁	Homo sapiens	PD168368	-	-	3.6	2025-07-09	To be published
	9I52	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-	Gs/β1/γ2	2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I52 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	A1IZU	-		2.8	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 176452091	-	Gs/β1/γ2	2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9I54 (No Gprot)	A	Amine	Dopamine	D₁	Homo sapiens	PubChem 176452091	-		2.72	2025-07-16	doi.org/10.1021/acs.jmedchem.5c00294
	9V0U	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9V0U (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	-	-		3.51	2025-07-30	doi.org/10.1016/j.bbrc.2025.152165
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

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