psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:Q2	6.77	Yes	Yes	1	0	0
2	L:L:?1	L:L:W3	12.55	Yes	Yes	1	0	0
3	L:L:?1	R:R:D193	3.45	Yes	Yes	1	0	1
4	L:L:?1	R:R:F200	7.22	Yes	No	0	0	2
5	L:L:?1	R:R:D303	5.75	Yes	No	1	0	2
6	L:L:?1	R:R:S305	3.82	Yes	No	0	0	2
7	L:L:Q2	R:R:T106	4.25	Yes	No	1	0	5
8	L:L:Q2	R:R:G112	4.93	Yes	No	0	0	4
9	L:L:Q2	R:R:W113	4.38	Yes	Yes	1	0	8
10	L:L:Q2	R:R:S202	11.55	Yes	No	0	0	3
11	L:L:A4	L:L:W3	9.08	No	Yes	0	0	0
12	L:L:W3	R:R:Y108	4.82	Yes	Yes	1	0	5
13	L:L:W3	R:R:H308	3.17	Yes	Yes	1	0	3
14	L:L:W3	R:R:F309	14.03	Yes	No	1	0	4
15	L:L:?6	L:L:V5	5.21	No	No	0	0	0
16	L:L:?6	L:L:H7	12	No	Yes	0	0	0
17	L:L:?6	R:R:H294	6	No	Yes	0	0	4
18	L:L:H7	R:R:S124	6.97	Yes	Yes	1	0	5
19	L:L:H7	R:R:R127	7.9	Yes	Yes	1	0	6
20	L:L:H7	R:R:E182	6.15	Yes	Yes	1	0	5
21	L:L:H7	R:R:C203	7.37	Yes	No	1	0	9
22	L:L:H7	R:R:S205	6.97	Yes	No	1	0	4
23	L:L:?9	L:L:F8	11.42	Yes	Yes	1	0	0
24	L:L:F8	R:R:C221	4.19	Yes	No	0	0	5
25	L:L:F8	R:R:N287	6.04	Yes	Yes	1	0	7
26	L:L:F8	R:R:H288	6.79	Yes	Yes	1	0	7
27	L:L:F8	R:R:Y291	16.5	Yes	No	0	0	6
28	L:L:?9	R:R:L96	3.89	Yes	No	0	0	7
29	L:L:?9	R:R:R127	20.5	Yes	Yes	1	0	6
30	L:L:?9	R:R:V131	5.59	Yes	No	1	0	8
31	L:L:?9	R:R:W284	3.2	Yes	Yes	1	0	8
32	L:L:?9	R:R:N287	9.01	Yes	Yes	1	0	7
33	L:L:?9	R:R:R316	13.67	Yes	Yes	1	0	5
34	R:R:I313	R:R:I50	5.89	No	No	0	4	5
35	R:R:Y108	R:R:Y51	7.94	Yes	No	0	5	5
36	R:R:I58	R:R:Y54	13.3	No	Yes	1	7	7
37	R:R:C100	R:R:Y54	5.38	Yes	Yes	1	6	7
38	R:R:D104	R:R:Y54	13.79	Yes	Yes	1	6	7
39	R:R:F320	R:R:Y54	5.16	Yes	Yes	1	7	7
40	R:R:S59	R:R:V56	3.23	No	No	0	5	5
41	R:R:C100	R:R:I58	3.27	Yes	No	1	6	7
42	R:R:C324	R:R:V60	3.42	No	No	0	7	6
43	R:R:C324	R:R:G61	3.92	No	No	0	7	8
44	R:R:I62	R:R:L97	7.14	No	No	0	6	6
45	R:R:I67	R:R:L63	4.28	No	No	0	7	4
46	R:R:D93	R:R:N65	8.08	No	Yes	0	9	9
47	R:R:L94	R:R:N65	6.87	No	Yes	0	7	9
48	R:R:N65	R:R:P327	4.89	Yes	No	0	9	9
49	R:R:F341	R:R:I67	12.56	No	No	5	6	7
50	R:R:I67	R:R:L345	8.56	No	No	5	7	6
51	R:R:A90	R:R:L68	3.15	No	No	0	9	9
52	R:R:L68	R:R:P327	3.28	No	No	0	9	9
53	R:R:I69	R:R:K70	5.82	No	No	0	7	4
54	R:R:T75	R:R:V71	3.17	Yes	No	2	5	7
55	R:R:H340	R:R:V71	8.3	No	No	0	5	7
56	R:R:Q344	R:R:V71	4.3	No	No	2	5	7
57	R:R:F72	R:R:F73	4.29	Yes	No	0	7	4
58	R:R:F72	R:R:Q79	10.54	Yes	No	0	7	7
59	R:R:F72	R:R:I84	3.77	Yes	No	0	7	5
60	R:R:F72	R:R:T87	20.75	Yes	No	0	7	6
61	R:R:F73	R:R:F91	3.22	No	No	0	4	6
62	R:R:K74	R:R:Q344	9.49	No	No	0	5	5
63	R:R:S77	R:R:T75	3.2	No	Yes	2	6	5
64	R:R:M78	R:R:T75	3.01	No	Yes	2	7	5
65	R:R:Q344	R:R:T75	4.25	No	Yes	2	5	5
66	R:R:K76	R:R:Q79	6.78	No	No	0	6	7
67	R:R:M78	R:R:S77	3.07	No	No	2	7	6
68	R:R:H340	R:R:M78	7.88	No	No	0	5	7
69	R:R:T80	R:R:V81	3.17	No	No	6	8	6
70	R:R:P82	R:R:T80	8.74	No	No	6	8	8
71	R:R:N83	R:R:T80	7.31	No	No	0	8	8
72	R:R:P82	R:R:V81	3.53	No	No	6	8	6
73	R:R:T164	R:R:V81	3.17	Yes	No	0	7	6
74	R:R:I84	R:R:T164	13.68	No	Yes	0	5	7
75	R:R:F85	R:R:I140	5.02	Yes	No	4	8	6
76	R:R:F85	R:R:L141	3.65	Yes	No	0	8	9
77	R:R:D144	R:R:F85	4.78	No	Yes	4	8	8
78	R:R:F85	R:R:T164	11.67	Yes	Yes	0	8	7
79	R:R:F85	R:R:K167	4.96	Yes	No	4	8	6
80	R:R:S88	R:R:T137	3.2	No	No	0	9	7
81	R:R:S88	R:R:W172	3.71	No	No	0	9	9
82	R:R:D93	R:R:L89	9.5	No	Yes	1	9	9
83	R:R:L89	R:R:S134	3	Yes	No	1	9	9
84	R:R:L89	R:R:T137	4.42	Yes	No	0	9	7
85	R:R:L138	R:R:L89	6.92	Yes	Yes	1	8	9
86	R:R:L89	R:R:N326	8.24	Yes	Yes	1	9	9
87	R:R:D93	R:R:N326	5.39	No	Yes	1	9	9
88	R:R:L95	R:R:S130	6.01	No	No	0	6	8
89	R:R:L95	R:R:W172	3.42	No	No	0	6	9
90	R:R:L96	R:R:S323	4.5	No	No	0	7	9
91	R:R:I126	R:R:T99	6.08	No	No	0	5	6
92	R:R:R127	R:R:T99	3.88	Yes	No	0	6	6
93	R:R:C100	R:R:D104	3.11	Yes	Yes	1	6	6
94	R:R:C100	R:R:F320	8.38	Yes	Yes	1	6	7
95	R:R:P102	R:R:V101	3.53	No	No	0	8	7
96	R:R:F115	R:R:P102	4.33	Yes	No	0	6	8
97	R:R:L123	R:R:P102	4.93	No	No	0	5	8
98	R:R:H107	R:R:V103	5.54	No	No	0	5	5
99	R:R:L123	R:R:V103	5.96	No	No	0	5	5
100	R:R:R127	R:R:V103	11.77	Yes	No	0	6	5
101	R:R:D104	R:R:Y108	4.6	Yes	Yes	1	6	5
102	R:R:D104	R:R:F320	8.36	Yes	Yes	1	6	7
103	R:R:T106	R:R:W113	7.28	No	Yes	1	5	8
104	R:R:F115	R:R:T106	5.19	Yes	No	1	6	5
105	R:R:H107	R:R:Y108	3.27	No	Yes	0	5	5
106	R:R:F309	R:R:Y108	6.19	No	Yes	1	4	5
107	R:R:I313	R:R:Y108	12.09	No	Yes	1	4	5
108	R:R:F115	R:R:W113	11.02	Yes	Yes	1	6	8
109	R:R:C120	R:R:W113	9.14	No	Yes	1	9	8
110	R:R:V188	R:R:W113	4.9	No	Yes	1	5	8
111	R:R:C203	R:R:W113	10.45	No	Yes	1	9	8
112	R:R:N187	R:R:R117	3.62	No	No	0	4	3
113	R:R:I118	R:R:V122	3.07	No	No	0	3	4
114	R:R:C120	R:R:V188	3.42	No	No	1	9	5
115	R:R:C120	R:R:C203	7.28	No	No	1	9	9
116	R:R:R127	R:R:S124	6.59	Yes	Yes	1	6	5
117	R:R:E182	R:R:S124	5.75	Yes	Yes	1	5	5
118	R:R:S124	R:R:S186	3.26	Yes	No	1	5	5
119	R:R:F125	R:R:T129	7.78	Yes	No	0	6	5
120	R:R:A183	R:R:F125	4.16	No	Yes	0	5	6
121	R:R:I126	R:R:S130	3.1	No	No	0	5	8
122	R:R:A179	R:R:L128	4.73	No	No	0	7	5
123	R:R:E182	R:R:L128	7.95	Yes	No	0	5	5
124	R:R:F225	R:R:L128	3.65	Yes	No	0	6	5
125	R:R:M176	R:R:T129	4.52	No	No	0	4	5
126	R:R:F225	R:R:V131	3.93	Yes	No	1	6	8
127	R:R:V131	R:R:W284	3.68	No	Yes	1	8	8
128	R:R:G132	R:R:S175	3.71	No	No	0	7	8
129	R:R:F225	R:R:G132	4.52	Yes	No	0	6	7
130	R:R:V133	R:R:W172	15.94	No	No	0	7	9
131	R:R:S175	R:R:V133	4.85	No	No	0	8	7
132	R:R:L138	R:R:S134	3	Yes	No	1	8	9
133	R:R:P229	R:R:V135	3.53	No	No	0	9	8
134	R:R:F136	R:R:V171	5.24	No	No	0	6	7
135	R:R:F136	R:R:V174	3.93	No	No	0	6	4
136	R:R:F136	R:R:S175	7.93	No	No	0	6	8
137	R:R:F280	R:R:L138	3.65	No	Yes	1	9	8
138	R:R:L138	R:R:N326	6.87	Yes	Yes	1	8	9
139	R:R:S142	R:R:T139	3.2	Yes	No	3	9	7
140	R:R:I232	R:R:T139	7.6	No	No	0	6	7
141	R:R:I233	R:R:T139	4.56	Yes	No	3	8	7
142	R:R:D144	R:R:I140	4.2	No	No	4	8	6
143	R:R:I140	R:R:K167	4.36	No	No	4	6	6
144	R:R:I233	R:R:S142	4.64	Yes	Yes	3	8	9
145	R:R:S142	R:R:Y236	7.63	Yes	Yes	0	9	7
146	R:R:S142	R:R:Y237	5.09	Yes	Yes	3	9	9
147	R:R:A143	R:R:Y236	5.34	No	Yes	0	6	7
148	R:R:V150	R:R:Y146	12.62	No	No	0	7	8
149	R:R:Y146	R:R:Y236	8.94	No	Yes	0	8	7
150	R:R:L239	R:R:Y146	8.21	No	No	0	5	8
151	R:R:I240	R:R:V149	4.61	No	No	0	8	9
152	R:R:T243	R:R:V149	3.17	No	No	0	6	9
153	R:R:K151	R:R:V150	4.55	No	No	0	6	7
154	R:R:T243	R:R:V150	6.35	No	No	0	6	7
155	R:R:E154	R:R:K151	18.9	No	No	0	4	6
156	R:R:P157	R:R:Q156	7.9	No	No	0	3	4
157	R:R:N159	R:R:S158	5.96	No	No	0	6	3
158	R:R:F178	R:R:V224	11.8	No	No	1	5	5
159	R:R:F178	R:R:F225	6.43	No	Yes	1	5	6
160	R:R:E182	R:R:S186	5.75	Yes	No	1	5	5
161	R:R:E182	R:R:S205	11.5	Yes	No	1	5	4
162	R:R:E182	R:R:H217	4.92	Yes	No	0	5	6
163	R:R:F185	R:R:I184	6.28	No	No	0	4	5
164	R:R:F185	R:R:Y206	15.47	No	Yes	0	4	3
165	R:R:F185	R:R:K210	4.96	No	No	0	4	4
166	R:R:S186	R:R:S205	3.26	No	No	1	5	4
167	R:R:N187	R:R:Y189	13.96	No	No	0	4	2
168	R:R:E201	R:R:V188	4.28	No	No	0	5	5
169	R:R:T204	R:R:Y189	6.24	No	No	0	4	2
170	R:R:P207	R:R:Y189	4.17	No	No	0	3	2
171	R:R:F191	R:R:F200	4.29	No	No	0	3	2
172	R:R:F191	R:R:T300	5.19	No	No	0	3	2
173	R:R:R192	R:R:T199	5.17	No	No	0	2	5
174	R:R:R192	R:R:Y301	3.09	No	No	0	2	2
175	R:R:D193	R:R:P194	4.83	Yes	No	0	1	1
176	R:R:D193	R:R:N195	4.04	Yes	No	0	1	3
177	R:R:D193	R:R:K196	5.53	Yes	No	0	1	3
178	R:R:D193	R:R:D303	11.98	Yes	No	1	1	2
179	R:R:P194	R:R:V302	3.53	No	No	0	1	1
180	R:R:K196	R:R:M198	8.64	No	No	0	3	3
181	R:R:P207	R:R:Y206	4.17	No	Yes	0	3	3
182	R:R:L213	R:R:Y206	4.69	No	Yes	0	4	3
183	R:R:Q214	R:R:Y206	9.02	No	Yes	0	3	3
184	R:R:H217	R:R:Y206	16.33	No	Yes	0	6	3
185	R:R:K210	R:R:P207	10.04	No	No	0	4	3
186	R:R:T300	R:R:V208	6.35	No	No	0	2	5
187	R:R:K210	R:R:L213	7.05	No	No	0	4	4
188	R:R:K211	R:R:S298	12.24	No	No	0	2	4
189	R:R:Q214	R:R:S295	8.66	No	No	0	3	4
190	R:R:E215	R:R:F296	20.99	Yes	No	0	3	5
191	R:R:S218	R:R:Y291	10.17	No	No	0	5	6
192	R:R:L292	R:R:S218	4.5	No	No	0	5	5
193	R:R:S218	R:R:S295	6.52	No	No	0	5	4
194	R:R:C221	R:R:F225	6.98	No	Yes	0	5	6
195	R:R:F222	R:R:Y226	14.44	Yes	Yes	1	6	8
196	R:R:F222	R:R:I227	7.54	Yes	No	0	6	4
197	R:R:F222	R:R:H288	7.92	Yes	Yes	1	6	7
198	R:R:F222	R:R:L292	4.87	Yes	No	0	6	5
199	R:R:I227	R:R:L223	4.28	No	No	0	4	5
200	R:R:I228	R:R:L223	4.28	No	No	0	5	5
201	R:R:F225	R:R:V224	3.93	Yes	No	1	6	5
202	R:R:F225	R:R:H288	3.39	Yes	Yes	1	6	7
203	R:R:L230	R:R:Y226	5.86	No	Yes	0	6	8
204	R:R:L285	R:R:Y226	11.72	No	Yes	0	6	8
205	R:R:H288	R:R:Y226	11.98	Yes	Yes	1	7	8
206	R:R:I228	R:R:P229	3.39	No	No	0	5	9
207	R:R:L230	R:R:S234	3	No	No	0	6	4
208	R:R:A281	R:R:L230	3.15	No	No	0	5	6
209	R:R:I232	R:R:Y236	13.3	No	Yes	0	6	7
210	R:R:I233	R:R:Y237	8.46	Yes	Yes	3	8	9
211	R:R:I233	R:R:V277	3.07	Yes	No	3	8	8
212	R:R:S234	R:R:V277	4.85	No	No	0	4	8
213	R:R:V235	R:R:Y236	3.79	No	Yes	0	4	7
214	R:R:V273	R:R:Y237	8.83	No	Yes	0	8	9
215	R:R:L276	R:R:Y237	4.69	No	Yes	0	8	9
216	R:R:V277	R:R:Y237	3.79	No	Yes	3	8	9
217	R:R:L239	R:R:R242	3.64	No	No	0	5	4
218	R:R:A241	R:R:Y245	4	No	No	7	5	5
219	R:R:A241	R:R:L274	4.73	No	No	7	5	5
220	R:R:K246	R:R:R242	3.71	No	No	0	4	4
221	R:R:I269	R:R:L244	4.28	No	No	0	7	8
222	R:R:A270	R:R:L244	4.73	No	No	0	7	8
223	R:R:A270	R:R:Y245	5.34	No	No	0	7	5
224	R:R:L274	R:R:Y245	3.52	No	No	7	5	5
225	R:R:R266	R:R:S247	9.22	No	No	0	7	7
226	R:R:I263	R:R:T248	6.08	No	No	8	3	4
227	R:R:R266	R:R:T248	3.88	No	No	0	7	4
228	R:R:K267	R:R:T248	3	Yes	No	8	5	4
229	R:R:I251	R:R:P252	3.39	Yes	No	0	4	4
230	R:R:I251	R:R:R266	6.26	Yes	No	0	4	7
231	R:R:I263	R:R:T253	3.04	No	No	0	3	4
232	R:R:E255	R:R:H258	13.54	No	No	0	1	4
233	R:R:A259	R:R:E255	4.53	No	No	0	3	1
234	R:R:I263	R:R:K267	5.82	No	Yes	8	3	5
235	R:R:R268	R:R:R271	3.2	No	No	0	7	7
236	R:R:R268	R:R:W332	13	No	No	0	7	6
237	R:R:T272	R:R:W332	14.55	No	No	0	8	6
238	R:R:L279	R:R:V275	4.47	No	No	0	7	6
239	R:R:A329	R:R:L276	4.73	No	No	0	8	8
240	R:R:F280	R:R:W284	18.04	No	Yes	1	9	8
241	R:R:F280	R:R:N322	8.46	No	Yes	1	9	9
242	R:R:C283	R:R:S321	5.16	No	No	0	8	5
243	R:R:C283	R:R:N322	3.15	No	Yes	0	8	9
244	R:R:H288	R:R:W284	7.41	Yes	Yes	1	7	8
245	R:R:N322	R:R:W284	13.56	Yes	Yes	1	9	8
246	R:R:L285	R:R:P286	3.28	No	No	0	6	9
247	R:R:L285	R:R:L289	8.3	No	No	0	6	6
248	R:R:P286	R:R:S315	3.56	No	No	0	9	6
249	R:R:L318	R:R:P286	4.93	No	No	0	7	9
250	R:R:N287	R:R:R316	8.44	Yes	Yes	1	7	5
251	R:R:A319	R:R:N287	4.69	No	Yes	0	8	7
252	R:R:H294	R:R:L290	10.29	Yes	No	0	4	4
253	R:R:L290	R:R:T312	8.84	No	No	0	4	4
254	R:R:L290	R:R:R316	3.64	No	Yes	0	4	5
255	R:R:H294	R:R:Y293	3.27	Yes	No	1	4	5
256	R:R:T297	R:R:Y293	8.74	No	No	0	4	5
257	R:R:H308	R:R:Y293	3.27	Yes	No	1	3	5
258	R:R:H294	R:R:H308	3.58	Yes	Yes	1	4	3
259	R:R:Q299	R:R:V302	10.03	No	No	0	1	1
260	R:R:P304	R:R:Q299	6.32	No	No	0	1	1
261	R:R:T300	R:R:Y301	13.73	No	No	0	2	2
262	R:R:F311	R:R:H308	6.79	No	Yes	0	5	3
263	R:R:F309	R:R:I313	3.77	No	No	1	4	4
264	R:R:F311	R:R:S315	5.28	No	No	0	5	6
265	R:R:F314	R:R:L318	13.4	No	No	0	5	7
266	R:R:F320	R:R:R316	3.21	Yes	Yes	1	7	5
267	R:R:N322	R:R:N326	8.17	Yes	Yes	1	9	9
268	R:R:F337	R:R:L330	14.61	Yes	No	0	9	9
269	R:R:Q338	R:R:Y331	29.31	No	Yes	0	8	7
270	R:R:F341	R:R:Y331	7.22	No	Yes	0	6	7
271	R:R:K342	R:R:Y331	5.97	No	Yes	0	5	7
272	R:R:F337	R:R:H340	11.31	Yes	No	0	9	5
273	R:R:F341	R:R:L345	3.65	No	No	5	6	6
274	R:R:L244	R:R:V149	2.98	No	No	0	8	9
275	R:R:L279	R:R:V325	2.98	No	No	0	7	6
276	R:R:L141	R:R:T137	2.95	No	No	0	9	7
277	R:R:L333	R:R:T272	2.95	No	No	0	6	8
278	R:R:I310	R:R:I50	2.94	No	No	0	1	5
279	R:R:I161	R:R:I84	2.94	No	No	0	3	5
280	R:R:I69	R:R:L94	2.85	No	No	0	7	7
281	R:R:I86	R:R:L141	2.85	No	No	0	8	9
282	R:R:I86	R:R:L330	2.85	No	No	0	8	9
283	R:R:G116	R:R:W113	2.81	No	Yes	0	8	8
284	R:R:C324	R:R:F328	2.79	No	No	0	7	7
285	R:R:A179	R:R:F125	2.77	No	Yes	0	7	6
286	R:R:L330	R:R:L333	2.77	No	No	0	9	6
287	R:R:E215	R:R:K211	2.7	Yes	No	0	3	2
288	R:R:F337	R:R:S334	2.64	Yes	No	0	9	8
289	R:R:K267	R:R:R271	2.48	Yes	No	0	5	7
290	R:R:F125	R:R:L180	2.44	Yes	No	0	6	4
291	R:R:L333	R:R:R145	2.43	No	No	0	6	9
292	R:R:L47	R:R:Y51	2.34	No	No	0	3	5
293	R:R:F337	R:R:Y331	2.06	Yes	Yes	0	9	7
294	R:R:G92	R:R:V133	1.84	No	No	0	8	7
295	R:R:G119	R:R:I118	1.76	No	No	0	5	3
296	R:R:G61	R:R:L97	1.71	No	No	0	8	6
297	R:R:G64	R:R:L63	1.71	No	No	0	8	4
298	R:R:A168	R:R:S88	1.71	No	No	0	8	9
299	R:R:C170	R:R:V166	1.71	No	No	0	3	3
300	R:R:G61	R:R:N65	1.7	No	Yes	0	8	9
301	R:R:A329	R:R:V325	1.7	No	No	0	8	6
302	R:R:C165	R:R:T164	1.69	No	Yes	0	4	7
303	R:R:K151	R:R:P152	1.67	No	No	0	6	8
304	R:R:E111	R:R:G112	1.64	No	No	0	3	4
305	R:R:L180	R:R:P181	1.64	No	No	0	4	7
306	R:R:S334	R:R:S336	1.63	No	No	0	8	6
307	R:R:S59	R:R:V60	1.62	No	No	0	5	6
308	R:R:A259	R:R:I251	1.62	No	Yes	0	3	4
309	R:R:A160	R:R:K163	1.61	No	No	0	7	4
310	R:R:T190	R:R:T199	1.57	No	No	0	1	5
311	R:R:I227	R:R:S231	1.55	No	No	0	4	4
312	R:R:I52	R:R:V56	1.54	No	No	0	5	5
313	R:R:I57	R:R:V317	1.54	No	No	0	8	5
314	L:L:Q2	R:R:A110	1.52	Yes	No	0	0	4
315	R:R:I50	R:R:T53	1.52	No	No	0	5	5
316	R:R:F115	R:R:G119	1.51	Yes	No	0	6	5
317	R:R:L318	R:R:V317	1.49	No	No	0	7	5
318	R:R:I173	R:R:I177	1.47	No	No	0	3	4
319	R:R:I118	R:R:K121	1.45	No	No	0	3	7
320	R:R:E215	R:R:S295	1.44	Yes	No	0	3	4
321	R:R:Q262	R:R:S265	1.44	No	No	0	4	6
322	R:R:I62	R:R:L98	1.43	No	No	0	6	4
323	R:R:I177	R:R:L180	1.43	No	No	0	4	4
324	R:R:I216	R:R:L220	1.43	No	No	0	5	4
325	R:R:L109	R:R:L47	1.38	No	No	0	5	3
326	R:R:I251	R:R:Q262	1.37	Yes	No	0	4	4
327	R:R:K147	R:R:Q156	1.36	No	No	0	5	4
328	R:R:E264	R:R:K267	1.35	No	Yes	0	4	5
329	R:R:C48	R:R:Y51	1.34	No	No	0	5	5
330	R:R:E215	R:R:L212	1.33	Yes	No	0	3	1
331	R:R:R260	R:R:S257	1.32	No	No	0	3	2
332	R:R:E254	R:R:Q256	1.27	No	No	0	4	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.59333	6	1	0
2	L:L:Q2	5.56667	6	1	0
3	L:L:W3	8.73	5	1	0
4	L:L:H7	7.89333	6	1	0
5	L:L:F8	8.988	5	1	0
6	L:L:?9	9.61143	7	1	0
7	R:R:Y54	9.4075	4	1	7
8	R:R:N65	5.385	4	0	9
9	R:R:F72	9.8375	4	0	7
10	R:R:T75	3.4075	4	2	5
11	R:R:F85	6.016	5	4	8
12	R:R:L89	6.416	5	1	9
13	R:R:C100	5.035	4	1	6
14	R:R:D104	7.465	4	1	6
15	R:R:Y108	6.485	6	1	5
16	R:R:W113	7.14	7	1	8
17	R:R:F115	5.5125	4	1	6
18	R:R:S124	5.6425	4	1	5
19	R:R:F125	4.2875	4	0	6
20	R:R:R127	10.128	5	1	6
21	R:R:L138	5.11	4	1	8
22	R:R:S142	5.14	4	3	9
23	R:R:T164	7.5525	4	0	7
24	R:R:E182	7.00333	6	1	5
25	R:R:D193	5.966	5	1	1
26	R:R:Y206	9.936	5	0	3
27	R:R:E215	6.615	4	0	3
28	R:R:F222	8.6925	4	1	6
29	R:R:F225	4.69	7	1	6
30	R:R:Y226	11	4	1	8
31	R:R:I233	5.1825	4	3	8
32	R:R:Y236	7.8	5	0	7
33	R:R:Y237	6.172	5	3	9
34	R:R:I251	3.16	4	0	4
35	R:R:K267	3.1625	4	8	5
36	R:R:W284	9.178	5	1	8
37	R:R:N287	7.045	4	1	7
38	R:R:H288	7.498	5	1	7
39	R:R:H294	5.785	4	1	4
40	R:R:H308	4.2025	4	1	3
41	R:R:R316	7.24	4	1	5
42	R:R:F320	6.2775	4	1	7
43	R:R:N322	8.335	4	1	9
44	R:R:N326	7.1675	4	1	9
45	R:R:Y331	11.14	4	0	7
46	R:R:F337	7.655	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:Q2	12.5861	6.77	Yes	Yes	1	0	0
2	L:L:Q2	R:R:W113	15.1707	4.38	Yes	Yes	1	0	8
3	L:L:?1	L:L:W3	27.8333	12.55	Yes	Yes	1	0	0
4	L:L:W3	R:R:Y108	18.9076	4.82	Yes	Yes	1	0	5
5	L:L:W3	R:R:H308	15.678	3.17	Yes	Yes	1	0	3
6	R:R:C203	R:R:W113	23.2524	10.45	No	Yes	1	9	8
7	L:L:H7	R:R:C203	26.9368	7.37	Yes	No	1	0	9
8	L:L:H7	R:R:R127	28.3362	7.9	Yes	Yes	1	0	6
9	R:R:H107	R:R:Y108	16.3318	3.27	No	Yes	0	5	5
10	R:R:H107	R:R:V103	17.073	5.54	No	No	0	5	5
11	R:R:R127	R:R:V103	23.3354	11.77	Yes	No	0	6	5
12	L:L:H7	R:R:E182	14.0949	6.15	Yes	Yes	1	0	5
13	L:L:?9	R:R:R127	54.9363	20.5	Yes	Yes	1	0	6
14	R:R:D104	R:R:Y108	16.9615	4.6	Yes	Yes	1	6	5
15	R:R:D104	R:R:F320	17.003	8.36	Yes	Yes	1	6	7
16	R:R:F320	R:R:R316	21.947	3.21	Yes	Yes	1	7	5
17	L:L:?9	R:R:R316	30.6956	13.67	Yes	Yes	1	0	5
18	R:R:H294	R:R:L290	10.9396	10.29	Yes	No	0	4	4
19	R:R:L290	R:R:R316	12.3871	3.64	No	Yes	0	4	5
20	L:L:?9	L:L:F8	16.3274	11.42	Yes	Yes	1	0	0
21	R:R:E182	R:R:L128	20.9608	7.95	Yes	No	0	5	5
22	R:R:F225	R:R:L128	28.8632	3.65	Yes	No	0	6	5
23	L:L:F8	R:R:H288	18.2385	6.79	Yes	Yes	1	0	7
24	L:L:?9	R:R:W284	74.8103	3.2	Yes	Yes	1	0	8
25	R:R:H288	R:R:W284	51.3327	7.41	Yes	Yes	1	7	8
26	R:R:F225	R:R:H288	19.9025	3.39	Yes	Yes	1	6	7
27	R:R:L285	R:R:P286	10.8456	3.28	No	No	0	6	9
28	R:R:L285	R:R:Y226	12.2537	11.72	No	Yes	0	6	8
29	R:R:H288	R:R:Y226	51.9822	11.98	Yes	Yes	1	7	8
30	R:R:N322	R:R:W284	64.6142	13.56	Yes	Yes	1	9	8
31	R:R:N322	R:R:N326	62.8518	8.17	Yes	Yes	1	9	9
32	R:R:D93	R:R:N326	14.1277	5.39	No	Yes	1	9	9
33	R:R:D93	R:R:N65	16.2421	8.08	No	Yes	0	9	9
34	R:R:F280	R:R:W284	49.8546	18.04	No	Yes	1	9	8
35	R:R:F280	R:R:L138	49.3036	3.65	No	Yes	1	9	8
36	R:R:L138	R:R:L89	47.8866	6.92	Yes	Yes	1	8	9
37	R:R:L89	R:R:T137	97.6406	4.42	Yes	No	0	9	7
38	R:R:L141	R:R:T137	100	2.95	No	No	0	9	7
39	R:R:I86	R:R:L141	69.991	2.85	No	No	0	8	9
40	R:R:I86	R:R:L330	68.3511	2.85	No	No	0	8	9
41	R:R:F337	R:R:L330	33.326	14.61	Yes	No	0	9	9
42	R:R:F337	R:R:Y331	14.2282	2.06	Yes	Yes	0	9	7
43	R:R:L89	R:R:N326	48.1928	8.24	Yes	Yes	1	9	9
44	R:R:F337	R:R:H340	14.1889	11.31	Yes	No	0	9	5
45	R:R:F85	R:R:L141	31.6686	3.65	Yes	No	0	8	9
46	R:R:F85	R:R:T164	24.7305	11.67	Yes	Yes	0	8	7
47	R:R:I84	R:R:T164	14.1954	13.68	No	Yes	0	5	7
48	R:R:F72	R:R:I84	10.6444	3.77	Yes	No	0	7	5
49	R:R:E182	R:R:H217	25.9659	4.92	Yes	No	0	5	6
50	R:R:H217	R:R:Y206	24.0767	16.33	No	Yes	0	6	3
51	R:R:P207	R:R:Y206	12.6386	4.17	No	Yes	0	3	3
52	R:R:A179	R:R:L128	11.648	4.73	No	No	0	7	5
53	R:R:A179	R:R:F125	10.3711	2.77	No	Yes	0	7	6
54	R:R:L230	R:R:Y226	56.3947	5.86	No	Yes	0	6	8
55	R:R:L230	R:R:S234	54.6061	3	No	No	0	6	4
56	R:R:S234	R:R:V277	53.7052	4.85	No	No	0	4	8
57	R:R:I233	R:R:V277	24.3566	3.07	Yes	No	3	8	8
58	R:R:I233	R:R:S142	21.3391	4.64	Yes	Yes	3	8	9
59	R:R:V277	R:R:Y237	28.4412	3.79	No	Yes	3	8	9
60	R:R:S142	R:R:Y237	21.6605	5.09	Yes	Yes	3	9	9
61	R:R:S142	R:R:Y236	41.001	7.63	Yes	Yes	0	9	7
62	R:R:Y146	R:R:Y236	34.9769	8.94	No	Yes	0	8	7
63	R:R:V150	R:R:Y146	26.7903	12.62	No	No	0	7	8
64	R:R:T243	R:R:V150	18.5315	6.35	No	No	0	6	7
65	R:R:T243	R:R:V149	16.5592	3.17	No	No	0	6	9
66	L:L:?1	R:R:F200	15.1816	7.22	Yes	No	0	0	2
67	R:R:F191	R:R:F200	13.2989	4.29	No	No	0	3	2
68	R:R:F191	R:R:T300	11.4119	5.19	No	No	0	3	2
69	L:L:?1	R:R:D193	15.1641	3.45	Yes	Yes	1	0	1
70	R:R:L244	R:R:V149	12.3937	2.98	No	No	0	8	9
71	R:R:L330	R:R:L333	35.0447	2.77	No	No	0	9	6
72	R:R:L333	R:R:T272	31.5964	2.95	No	No	0	6	8
73	R:R:T272	R:R:W332	29.9324	14.55	No	No	0	8	6
74	R:R:R268	R:R:W332	28.1941	13	No	No	0	7	6
75	R:R:R268	R:R:R271	26.4601	3.2	No	No	0	7	7
76	R:R:K267	R:R:R271	24.7196	2.48	Yes	No	0	5	7
77	R:R:K267	R:R:T248	17.6874	3	Yes	No	8	5	4
78	R:R:R266	R:R:T248	16.0409	3.88	No	No	0	7	4
79	R:R:I251	R:R:R266	12.5008	6.26	Yes	No	0	4	7
80	R:R:F225	R:R:V131	11.0227	3.93	Yes	No	1	6	8
81	R:R:S218	R:R:S295	11.9389	6.52	No	No	0	5	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D193	3.45	1	Yes	Yes	0	1	0	1
L:L:?1	R:R:F200	7.22	1	Yes	No	0	2	0	1
L:L:?1	R:R:D303	5.75	1	Yes	No	0	2	0	1
L:L:?1	R:R:S305	3.82	1	Yes	No	0	2	0	1
L:L:Q2	R:R:T106	4.25	1	Yes	No	0	5	0	1
L:L:Q2	R:R:G112	4.93	1	Yes	No	0	4	0	1
L:L:Q2	R:R:W113	4.38	1	Yes	Yes	0	8	0	1
L:L:Q2	R:R:S202	11.55	1	Yes	No	0	3	0	1
L:L:W3	R:R:Y108	4.82	1	Yes	Yes	0	5	0	1
L:L:W3	R:R:H308	3.17	1	Yes	Yes	0	3	0	1
L:L:W3	R:R:F309	14.03	1	Yes	No	0	4	0	1
L:L:?6	R:R:H294	6	0	No	Yes	0	4	0	1
L:L:H7	R:R:S124	6.97	1	Yes	Yes	0	5	0	1
L:L:H7	R:R:R127	7.9	1	Yes	Yes	0	6	0	1
L:L:H7	R:R:E182	6.15	1	Yes	Yes	0	5	0	1
L:L:H7	R:R:C203	7.37	1	Yes	No	0	9	0	1
L:L:H7	R:R:S205	6.97	1	Yes	No	0	4	0	1
L:L:F8	R:R:C221	4.19	1	Yes	No	0	5	0	1
L:L:F8	R:R:N287	6.04	1	Yes	Yes	0	7	0	1
L:L:F8	R:R:H288	6.79	1	Yes	Yes	0	7	0	1
L:L:F8	R:R:Y291	16.5	1	Yes	No	0	6	0	1
L:L:?9	R:R:L96	3.89	1	Yes	No	0	7	0	1
L:L:?9	R:R:R127	20.5	1	Yes	Yes	0	6	0	1
L:L:?9	R:R:V131	5.59	1	Yes	No	0	8	0	1
L:L:?9	R:R:W284	3.2	1	Yes	Yes	0	8	0	1
L:L:?9	R:R:N287	9.01	1	Yes	Yes	0	7	0	1
L:L:?9	R:R:R316	13.67	1	Yes	Yes	0	5	0	1
R:R:Y108	R:R:Y51	7.94	1	Yes	No	5	5	1	2
R:R:L96	R:R:S323	4.5	0	No	No	7	9	1	2
R:R:R127	R:R:T99	3.88	1	Yes	No	6	6	1	2
R:R:H107	R:R:V103	5.54	0	No	No	5	5	2	2
R:R:R127	R:R:V103	11.77	1	Yes	No	6	5	1	2
R:R:D104	R:R:Y108	4.6	1	Yes	Yes	6	5	2	1
R:R:D104	R:R:F320	8.36	1	Yes	Yes	6	7	2	2
R:R:T106	R:R:W113	7.28	1	No	Yes	5	8	1	1
R:R:F115	R:R:T106	5.19	1	Yes	No	6	5	2	1
R:R:H107	R:R:Y108	3.27	0	No	Yes	5	5	2	1
R:R:F309	R:R:Y108	6.19	1	No	Yes	4	5	1	1
R:R:I313	R:R:Y108	12.09	1	No	Yes	4	5	2	1
R:R:F115	R:R:W113	11.02	1	Yes	Yes	6	8	2	1
R:R:C120	R:R:W113	9.14	1	No	Yes	9	8	2	1
R:R:V188	R:R:W113	4.9	1	No	Yes	5	8	2	1
R:R:C203	R:R:W113	10.45	1	No	Yes	9	8	1	1
R:R:C120	R:R:V188	3.42	1	No	No	9	5	2	2
R:R:C120	R:R:C203	7.28	1	No	No	9	9	2	1
R:R:R127	R:R:S124	6.59	1	Yes	Yes	6	5	1	1
R:R:E182	R:R:S124	5.75	1	Yes	Yes	5	5	1	1
R:R:S124	R:R:S186	3.26	1	Yes	No	5	5	1	2
R:R:E182	R:R:L128	7.95	1	Yes	No	5	5	1	2
R:R:F225	R:R:L128	3.65	1	Yes	No	6	5	2	2
R:R:F225	R:R:V131	3.93	1	Yes	No	6	8	2	1
R:R:V131	R:R:W284	3.68	1	No	Yes	8	8	1	1
R:R:E182	R:R:S186	5.75	1	Yes	No	5	5	1	2
R:R:E182	R:R:S205	11.5	1	Yes	No	5	4	1	1
R:R:E182	R:R:H217	4.92	1	Yes	No	5	6	1	2
R:R:S186	R:R:S205	3.26	1	No	No	5	4	2	1
R:R:F191	R:R:F200	4.29	0	No	No	3	2	2	1
R:R:D193	R:R:P194	4.83	1	Yes	No	1	1	1	2
R:R:D193	R:R:N195	4.04	1	Yes	No	1	3	1	2
R:R:D193	R:R:K196	5.53	1	Yes	No	1	3	1	2
R:R:D193	R:R:D303	11.98	1	Yes	No	1	2	1	1
R:R:S218	R:R:Y291	10.17	0	No	No	5	6	2	1
R:R:C221	R:R:F225	6.98	0	No	Yes	5	6	1	2
R:R:F222	R:R:Y226	14.44	1	Yes	Yes	6	8	2	2
R:R:F222	R:R:H288	7.92	1	Yes	Yes	6	7	2	1
R:R:F225	R:R:H288	3.39	1	Yes	Yes	6	7	2	1
R:R:H288	R:R:Y226	11.98	1	Yes	Yes	7	8	1	2
R:R:F280	R:R:W284	18.04	1	No	Yes	9	8	2	1
R:R:F280	R:R:N322	8.46	1	No	Yes	9	9	2	2
R:R:H288	R:R:W284	7.41	1	Yes	Yes	7	8	1	1
R:R:N322	R:R:W284	13.56	1	Yes	Yes	9	8	2	1
R:R:N287	R:R:R316	8.44	1	Yes	Yes	7	5	1	1
R:R:A319	R:R:N287	4.69	0	No	Yes	8	7	2	1
R:R:H294	R:R:L290	10.29	1	Yes	No	4	4	1	2
R:R:L290	R:R:R316	3.64	0	No	Yes	4	5	2	1
R:R:H294	R:R:Y293	3.27	1	Yes	No	4	5	1	2
R:R:H308	R:R:Y293	3.27	1	Yes	No	3	5	1	2
R:R:H294	R:R:H308	3.58	1	Yes	Yes	4	3	1	1
R:R:F311	R:R:H308	6.79	0	No	Yes	5	3	2	1
R:R:F309	R:R:I313	3.77	1	No	No	4	4	1	2
R:R:F320	R:R:R316	3.21	1	Yes	Yes	7	5	2	1
R:R:G116	R:R:W113	2.81	0	No	Yes	8	8	2	1
R:R:E111	R:R:G112	1.64	0	No	No	3	4	2	1
L:L:Q2	R:R:A110	1.52	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8Y52_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3
Number of Linked Nodes	284
Number of Links	332
Number of Hubs	46
Number of Links mediated by Hubs	169
Number of Communities	8
Number of Nodes involved in Communities	73
Number of Links involved in Communities	106

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	94246
Length Of Smallest Path	3
Average Path Length	15.737
Length of Longest Path	36
Minimum Path Strength	1.385
Average Path Strength	6.79884
Maximum Path Strength	18.265
Minimum Path Correlation	0.7
Average Path Correlation	0.928741
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	48.9878
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.2064
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • biological regulation • regulation of signal transduction • cell communication • regulation of response to stimulus
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • biological regulation • regulation of signal transduction • cell communication • regulation of response to stimulus • regulation of cell communication • cellular process • signal transduction • Wnt signaling pathway • G protein-coupled receptor signaling pathway • neuropeptide signaling pathway • multicellular organismal process • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • glutamate receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to hormone • response to chemical • response to endogenous stimulus • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • phototransduction, visible light • cell activation • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • membrane-bounded organelle • intracellular anatomical structure • nuclear membrane • nucleus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • organelle envelope • organelle • nuclear envelope • organelle membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • cytoplasm • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • Golgi apparatus • cytosolic region • postsynapse • synapse • cell junction • postsynaptic cytosol • cytosol • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • photoreceptor disc membrane • G-protein beta-subunit binding • fibroblast proliferation • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • bombesin receptor activity • circulatory system process • regulation of blood pressure • regulation of biological quality • blood circulation • behavior • adult feeding behavior • adult behavior • feeding behavior • monosaccharide metabolic process • carbohydrate metabolic process • hexose metabolic process • small molecule metabolic process • metabolic process • primary metabolic process • glucose metabolic process
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DPN
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	DPN
Name	D-Phenylalanine
Synonyms	D-Phenylalanine
Identifier
Formula	C9 H11 N O2
Molecular Weight	165.189
SMILES
PubChem	71567
Formal Charge	0
Total Atoms	23
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	6


Code	BAL
PDB Residues	L:L:?6
Environment Details	Open EMBL-EBI Page
Code	BAL
Name	beta-Alanine
Synonyms	ω-aminopropionic acid
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	4755801
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	0
Total Bonds	12
Total Aromatic Bonds	0


Code	NLE
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	NLE
Name	Norleucine
Synonyms	L-NORLEUCINE Norleucine
Identifier
Formula	C6 H13 N O2
Molecular Weight	131.173
SMILES
PubChem	21236
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32247
Sequence	>8Y52_nogp_Chain_R L C A I Y I T Y A V I I S V G I L G N A I L I K V F F K T K S M Q T V P N I F I T S L A F G D L L L L L T C V P V D A T H Y L A E G W L F G R I G C K V L S F I R L T S V G V S V F T L T I L S A D R Y K A V V K P L E R Q P S N A I L K T C V K A G C V W I V S M I F A L P E A I F S N V Y T F R D P N K N M T F E S C T S Y P V S K K L L Q E I H S L L C F L V F Y I I P L S I I S V Y Y S L I A R T L Y K S T L N I P T E E Q S H A R K Q I E S R K R I A R T V L V L V A L F A L C W L P N H L L Y L Y H S F T S Q T Y V D P S A M H F I F T I F S R V L A F S N S C V N P F A L Y W L S K S F Q K H F K A Q L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8Y52	A	Peptide	Bombesin	BB₃	Homo sapiens	BA1	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-09-11	doi.org/10.1016/j.celrep.2024.114511
	8Y52 (No Gprot)	A	Peptide	Bombesin	BB₃	Homo sapiens	BA1	-		2.9	2024-09-11	doi.org/10.1016/j.celrep.2024.114511
	8Y53	A	Peptide	Bombesin	BB₃	Homo sapiens	MK5046	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.93	2024-09-11	doi.org/10.1016/j.celrep.2024.114511
	8Y53 (No Gprot)	A	Peptide	Bombesin	BB₃	Homo sapiens	MK5046	-		2.93	2024-09-11	doi.org/10.1016/j.celrep.2024.114511
	8Y51	A	Peptide	Bombesin	BB₃	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.3	2025-02-12	To be published
	8Y51 (No Gprot)	A	Peptide	Bombesin	BB₃	Homo sapiens	-	-		3.3	2025-02-12	To be published
	9K07	A	Peptide	Bombesin	BB₃	Homo sapiens	DSO-5a	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.87	2025-08-27	/doi.org/10.1016/j.apsb.2025.06.025
	9K07 (No Gprot)	A	Peptide	Bombesin	BB₃	Homo sapiens	DSO-5a	-		2.87	2025-08-27	/doi.org/10.1016/j.apsb.2025.06.025
	9LWP	A	Peptide	Bombesin	BB₃	Homo sapiens	-	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.93	2025-07-16	doi.org/10.1016/j.apsb.2025.06.025
	9LWP (No Gprot)	A	Peptide	Bombesin	BB₃	Homo sapiens	-	-		2.93	2025-07-16	doi.org/10.1016/j.apsb.2025.06.025

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