Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:R42 5.734519
2A:A:K53 4.064297139
3A:A:T210 4.24254217
4A:A:V214 3.8675406
5A:A:F219 6.362867208
6A:A:M221 5.00254218
7A:A:F222 8.275417
8A:A:Q227 6.6225419
9A:A:K233 8.516519
10A:A:W234 7.67667619
11A:A:F238 9.935419
12A:A:T242 4.93254208
13A:A:D249 9.9425478
14A:A:D252 7.1475478
15A:A:Y253 8.2225408
16A:A:F273 8.8975449
17A:A:W277 10.335406
18A:A:W281 13.394515
19A:A:L289 5.67833649
20A:A:F290 5.456169
21A:A:L291 4.618548
22A:A:K293 7.19479
23A:A:L296 5.27476
24A:A:Y311 6.49406
25A:A:F312 3.90167608
26A:A:P321 6.14235
27A:A:D331 7.56754224
28A:A:V334 3.7465224
29A:A:F340 11.92407
30A:A:F345 9.7875448
31A:A:S349 4.23407
32A:A:Y360 8.276588
33A:A:P361 7.7445
34A:A:H362 7.58754169
35A:A:F363 9.785445
36A:A:F376 6.308508
37A:A:D381 7.004588
38A:A:N392 6.69754107
39B:B:M45 6.1325254
40B:B:H54 10.1185199
41B:B:Y59 5.92518
42B:B:W63 8.7445147
43B:B:D76 7.1675409
44B:B:I80 8.964198
45B:B:I81 4.5575467
46B:B:W82 14.81254199
47B:B:N88 7.42407
48B:B:K89 7.788336199
49B:B:L95 7.22408
50B:B:W99 8.65619
51B:B:M101 4.46519
52B:B:Y105 4.71714766
53B:B:Y111 7.1225414
54B:B:L117 4.9825419
55B:B:I123 4.172516
56B:B:Y124 7.1566
57B:B:V133 5.035464
58B:B:H142 7.145619
59B:B:Y145 5.83667618
60B:B:R150 5.3175406
61B:B:F151 8.4925419
62B:B:L152 3.725263
63B:B:I157 5.685417
64B:B:T159 5.9025419
65B:B:S161 7.3925419
66B:B:D163 8.4425419
67B:B:W169 13.4575418
68B:B:F180 7.485437
69B:B:D186 6.83419
70B:B:V187 3.964539
71B:B:L190 4.304505
72B:B:V200 7.065426
73B:B:S201 3.9625439
74B:B:C204 4.202517
75B:B:W211 9.695638
76B:B:F222 8.64428
77B:B:H225 9.012529
78B:B:I232 5.314528
79B:B:F235 9.2645176
80B:B:F241 6.71667626
81B:B:T243 6.5275428
82B:B:T249 5.485426
83B:B:R251 7.0575428
84B:B:F253 6.85286726
85B:B:D254 4.44509
86B:B:R256 6.6475409
87B:B:D258 10.2875427
88B:B:T263 7.5825421
89B:B:Y264 5.75505
90B:B:I269 4.244114
91B:B:F278 5.546676177
92B:B:Y289 7.0485117
93B:B:N295 5.414116
94B:B:V296 4.9775405
95B:B:R304 4.5354115
96B:B:H311 8.66254289
97B:B:R314 12.102518
98B:B:V320 4.44254127
99B:B:T321 6.09754147
100B:B:W332 8.895619
101B:B:D333 9.23754289
102B:B:K337 5.84406
103B:B:W339 10.8554259
104G:G:E22 5.475439
105G:G:S31 3.0725409
106G:G:H44 10.92254276
107G:G:D48 9.345129
108G:G:P49 5.8765127
109R:R:N65 6.15409
110R:R:I67 6.875407
111R:R:L68 4.29409
112R:R:I69 4.44754307
113R:R:V71 4.35754107
114R:R:T75 6.17754105
115R:R:M78 4.818577107
116R:R:F85 4.72598
117R:R:L89 6.986559
118R:R:D93 7.512559
119R:R:L96 4.16407
120R:R:L97 4.27406
121R:R:Y108 7.451676155
122R:R:T129 4.79254315
123R:R:V149 3.76409
124R:R:N159 4.86596
125R:R:T164 5.5025497
126R:R:S175 4.4025408
127R:R:L219 7.185185
128R:R:Y226 7.116558
129R:R:Y236 6.8325407
130R:R:Y237 6.3785329
131R:R:L244 3.9075408
132R:R:I251 4.342584
133R:R:Q262 4.7725484
134R:R:R266 6.876587
135R:R:I269 4.6925407
136R:R:W284 5.85558
137R:R:L290 7.48404
138R:R:H294 8.175404
139R:R:R316 4.8254155
140R:R:F320 5.4365157
141R:R:N322 6.285459
142R:R:N326 7.476559
143R:R:H340 7.0625105
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:S23 B:B:N88 36.87858.94NoYes077
2A:A:S23 B:B:K89 37.47387.65NoYes079
3B:B:I80 B:B:K89 20.53384.36YesYes1989
4B:B:H54 B:B:I80 21.111111.93YesYes1998
5B:B:H54 B:B:S74 43.60199.76YesNo099
6B:B:D76 B:B:S74 43.867310.31YesNo099
7B:B:D76 B:B:L55 45.20285.43YesNo096
8A:A:K34 B:B:L55 45.47058.46NoNo046
9A:A:K34 A:A:R38 45.742416.09NoNo044
10A:A:R38 R:R:R155 46.01844.26NoNo046
11A:A:N387 R:R:R155 46.57229.64NoNo086
12A:A:I383 A:A:N387 99.74964.25NoNo088
13A:A:I383 A:A:T242 1004.56NoYes088
14A:A:L41 A:A:T242 33.41838.84NoYes048
15A:A:F219 A:A:L41 33.46016.09YesNo084
16A:A:F212 A:A:F219 99.71516.08NoYes098
17A:A:F212 A:A:M221 99.6624.98NoYes098
18A:A:I245 A:A:M221 99.49532.92NoYes078
19A:A:I245 A:A:I375 99.46424.42NoNo079
20A:A:F290 A:A:I375 99.06015.02YesNo099
21A:A:F290 A:A:H362 91.68216.79YesYes1699
22A:A:H362 R:R:P252 84.13033.05YesNo094
23R:R:E254 R:R:P252 82.43716.29NoNo044
24A:A:R342 R:R:E254 42.267316.28NoNo044
25A:A:P361 A:A:R342 33.991315.85YesNo054
26A:A:L289 A:A:P361 67.96653.28YesYes495
27A:A:F246 A:A:L289 64.69814.87NoYes499
28A:A:D272 A:A:F246 64.77413.58NoNo089
29A:A:D272 A:A:R231 64.44778.34NoNo089
30A:A:R231 A:A:W234 64.12716NoYes099
31A:A:W234 B:B:Y145 57.68244.82YesYes198
32B:B:G162 B:B:Y145 34.866810.14NoYes198
33B:B:G162 B:B:S161 34.8353.71NoYes199
34B:B:K89 B:B:W82 20.565511.6YesYes1999
35B:B:H54 B:B:W82 21.11088.46YesYes1999
36A:A:L43 A:A:T242 33.41822.95NoYes2078
37A:A:F219 A:A:L43 33.463.65YesNo2087
38A:A:C379 A:A:T242 33.41823.38NoYes2088
39A:A:C379 A:A:F219 33.464.19NoYes2088
40R:R:E254 R:R:Q256 40.15975.1NoNo041
41A:A:P361 R:R:Q256 34.3817.9YesNo051
42A:A:F238 B:B:W99 10.584114.03YesYes199
43A:A:I244 A:A:V287 10.00243.07NoNo086
44A:A:K233 B:B:Y145 22.10023.58YesYes198
45A:A:K233 B:B:N230 20.47468.39YesNo099
46A:A:D378 A:A:Y360 15.781813.79NoYes078
47A:A:D381 A:A:Y360 14.77528.05YesYes888
48R:R:I251 R:R:P252 14.59885.08YesNo044
49A:A:D381 R:R:I251 12.94315.6YesYes884
50A:A:D381 R:R:R266 22.089310.72YesYes887
51R:R:L244 R:R:R266 18.83453.64YesYes087
52A:A:N387 R:R:A148 74.8414.69NoNo088
53R:R:I269 R:R:L244 13.67684.28YesYes078
54A:A:Y391 R:R:A148 74.48895.34NoNo048
55A:A:Y391 R:R:P82 13.74938.34NoNo048
56A:A:Y391 R:R:D144 60.45453.45NoNo048
57R:R:P82 R:R:T80 11.183610.49NoNo088
58R:R:N83 R:R:T80 10.82497.31NoNo088
59B:B:H142 B:B:S161 25.190712.55YesYes199
60B:B:H142 B:B:T159 23.61274.11YesYes199
61B:B:C149 B:B:T159 17.62746.76NoYes089
62B:B:C149 B:B:T102 17.40165.07NoNo088
63B:B:C148 B:B:T102 17.17693.38NoNo068
64B:B:C148 B:B:L190 15.3173.17NoYes065
65B:B:C218 B:B:W211 10.44899.14NoYes358
66B:B:N88 B:B:T86 33.091111.7YesNo076
67B:B:D83 B:B:T86 32.557210.12NoNo086
68B:B:D83 B:B:R68 32.076819.06NoNo085
69B:B:R68 B:B:Y85 31.603114.4NoNo054
70B:B:S84 B:B:Y85 31.14893.82NoNo054
71B:B:S84 B:B:W63 30.70754.94NoYes057
72B:B:L70 B:B:W63 23.487921.64NoYes1457
73B:B:L70 B:B:M61 23.32382.83NoNo056
74B:B:G319 B:B:M61 23.00783.49NoNo056
75B:B:G319 B:B:S277 22.85613.71NoNo055
76B:B:S277 B:B:V320 22.72054.85NoYes057
77B:B:L286 B:B:V320 12.43322.98NoYes1277
78B:B:L286 B:B:V296 12.35555.96NoYes075
79B:B:I43 B:B:V40 13.10453.07NoNo033
80B:B:D298 B:B:V40 12.76828.76NoNo093
81B:B:D298 B:B:R283 12.318911.91NoNo099
82B:B:L300 B:B:R283 12.06210.93NoNo069
83B:B:L300 B:B:T34 11.09485.9NoNo2465
84B:B:L30 B:B:T34 11.32684.42NoNo055
85B:B:L30 B:B:M262 10.26982.83NoNo054
86B:B:M262 B:B:Y264 10.0798.38NoYes045
87B:B:Q259 G:G:V30 10.19425.73NoNo068
88B:B:Q259 B:B:R22 10.50878.18NoNo066
89B:B:D258 B:B:R22 11.26814.76YesNo076
90B:B:D258 B:B:F222 12.43167.17YesYes278
91B:B:F222 B:B:F253 11.310112.86YesYes286
92B:B:D246 B:B:N230 20.294510.77NoNo099
93B:B:D246 B:B:S227 19.94822.94NoNo096
94B:B:S227 B:B:S245 19.7773.26NoNo069
95B:B:H225 B:B:S245 19.6095.58YesNo099
96R:R:D144 R:R:F85 59.34985.97NoYes988
97R:R:F85 R:R:L141 57.68893.65YesNo089
98R:R:L141 R:R:T137 57.32892.95NoNo097
99R:R:L89 R:R:T137 42.60365.9YesNo097
100R:R:D93 R:R:L89 27.8319.5YesYes599
101R:R:D93 R:R:S323 24.98110.31YesNo099
102R:R:L97 R:R:S323 19.22846.01YesNo069
103R:R:F320 R:R:L97 13.44573.65YesYes076
104R:R:F320 R:R:R316 11.96065.34YesYes1575
105R:R:L89 R:R:N326 13.66829.61YesYes599
106R:R:S88 R:R:T137 15.43964.8NoNo097
107R:R:S88 R:R:W172 14.29186.18NoNo099
108R:R:N322 R:R:N326 12.96379.54YesYes599
109R:R:V133 R:R:W172 13.908817.16NoNo079
110R:R:S175 R:R:V133 13.52576.46YesNo087
111B:B:F253 B:B:H225 16.70674.53YesYes269
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8Y51
Class A
SubFamily Peptide
Type Bombesin
SubType BB3
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 3.3
Date 2025-02-12
D.O.I. To be published
Net Summary
Imin 2.92
Number of Linked Nodes 845
Number of Links 999
Number of Hubs 143
Number of Links mediated by Hubs 535
Number of Communities 32
Number of Nodes involved in Communities 218
Number of Links involved in Communities 291
Path Summary
Number Of Nodes in MetaPath 112
Number Of Links MetaPath 111
Number of Shortest Paths 1596830
Length Of Smallest Path 3
Average Path Length 34.732
Length of Longest Path 60
Minimum Path Strength 1.25
Average Path Strength 6.54519
Maximum Path Strength 19.595
Minimum Path Correlation 0.7
Average Path Correlation 0.984073
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.27273
Average % Of Corr. Nodes 43.8911
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.1405
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8Y51_Chain_A
EKAEKIEKQ LQKDKQVYR TRLLLLGAS GKSTIVKQM RITSGIFET 
KFQVDKVNF HMFDVGQRD ERRKWIQCF NDVTAIIFV VSSYNRLQE 
ALNFKSIWN NRWLRTISV ILFLNKQDL LAEKVLAGK SKIEDYFPE 
FARYTTPED ATPEPGEDP RVTRAKYFI REFISTASG DGRHCYPHF 
TCVDTENRR FNDCDIIML RYLLSADAV RSMRLDNAD DDKVDISAI 
KLQNENV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8Y51_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8Y51_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP32247
Sequence
>8Y51_Chain_R
LCAIYITYA VIISVGILG NAILIKVFF KTKSMQTVP NIFITSLAF 
GDLLLLLTC VPVDATHYL AEGWLFGRI GCKVLSFIR LTSVGVSVF 
TLTILSADR YKAVVKPLE RQNAILKTC VKAGCVWIV SMIFALPEA 
IFKLLQEIH SLLCFLVFY IIPLSIISV YYSLIARTL YKSTLNIPT 
EEQSHARKQ IESRKRIAR TVLVLVALF ALCWLPNHL LYLYHSFTS 
QTYVDPSAM HFIFTIFSR VLAFSNSCV NPFALYWLS KSFQKHFKA 
QLFCCK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8Y52APeptideBombesinBB3Homo sapiensBA1-chim(NtGi1-Gs-CtGq)/β1/γ22.92024-09-11doi.org/10.1016/j.celrep.2024.114511
8Y52 (No Gprot) APeptideBombesinBB3Homo sapiensBA1-2.92024-09-11doi.org/10.1016/j.celrep.2024.114511
8Y53APeptideBombesinBB3Homo sapiensMK5046-chim(NtGi1-Gs-CtGq)/β1/γ22.932024-09-11doi.org/10.1016/j.celrep.2024.114511
8Y53 (No Gprot) APeptideBombesinBB3Homo sapiensMK5046-2.932024-09-11doi.org/10.1016/j.celrep.2024.114511
8Y51 (No Gprot) APeptideBombesinBB3Homo sapiens--3.32025-02-12To be published
9K07APeptideBombesinBB3Homo sapiensDSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ22.872025-08-27/doi.org/10.1016/j.apsb.2025.06.025
9K07 (No Gprot) APeptideBombesinBB3Homo sapiensDSO-5a-2.872025-08-27/doi.org/10.1016/j.apsb.2025.06.025
9LWPAPeptideBombesinBB3Homo sapiens--chim(NtGi2L-Gs-CtGq)/β1/γ22.932025-07-16doi.org/10.1016/j.apsb.2025.06.025
9LWP (No Gprot) APeptideBombesinBB3Homo sapiens--2.932025-07-16doi.org/10.1016/j.apsb.2025.06.025




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Download 8Y51.zip



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