Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 10.1511010
2R:R:Y54 9.295417
3R:R:I69 4.7625407
4R:R:T75 4.16465
5R:R:N83 6.4975478
6R:R:F85 7.8125488
7R:R:L89 6.418519
8R:R:D93 7.21419
9R:R:L96 3.835407
10R:R:D104 5.98516
11R:R:Y108 7.09333615
12R:R:W113 5.822508
13R:R:F125 5.964526
14R:R:R127 8.864516
15R:R:F136 4.365426
16R:R:S142 5.21449
17R:R:Y146 7.1075408
18R:R:S175 4.26428
19R:R:E182 7.38535
20R:R:Y189 3.615432
21R:R:F191 4.4675433
22R:R:D193 5.325401
23R:R:Y206 10.1583633
24R:R:P207 6.5975433
25R:R:F222 9.1925416
26R:R:F225 6.0575426
27R:R:Y226 6.926518
28R:R:I227 4.5625414
29R:R:L230 3.6225406
30R:R:Y236 5.268507
31R:R:Y237 5.998549
32R:R:L244 3.21408
33R:R:I251 3.716504
34R:R:I263 4.85493
35R:R:F280 6.4125419
36R:R:W284 6.668518
37R:R:N287 6.21517
38R:R:H288 10.465417
39R:R:L290 6.5675404
40R:R:F320 4.312517
41R:R:N322 4.395419
42R:R:N326 6.4775419
43R:R:Y331 10.56407
44R:R:F337 8.785409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:C100 31.36015.66YesNo006
2R:R:C100 R:R:D104 18.54614.67NoYes066
3R:R:D104 R:R:Y108 32.17253.45YesYes165
4R:R:Y108 R:R:Y51 22.26627.94YesNo055
5R:R:C48 R:R:Y51 11.16855.38NoNo055
6L:L:?1 R:R:V103 15.54263.19YesNo105
7R:R:D104 R:R:V103 20.03754.38YesNo165
8L:L:?1 R:R:N287 43.777.84YesYes107
9R:R:N287 R:R:R316 13.96798.44YesNo175
10R:R:R316 R:R:Y108 11.75173.09NoYes155
11R:R:C100 R:R:F320 19.85844.19NoYes067
12R:R:D104 R:R:Y54 11.697612.64YesYes167
13R:R:F320 R:R:L97 17.85463.65YesNo076
14R:R:G61 R:R:L97 13.8181.71NoNo086
15L:L:?1 R:R:R127 34.3478.67YesYes106
16R:R:L96 R:R:R127 22.97024.86YesYes076
17R:R:L96 R:R:S323 36.24663YesNo079
18R:R:D93 R:R:S323 45.98635.89YesNo099
19R:R:D93 R:R:N65 67.89848.08YesNo099
20R:R:N65 R:R:P327 48.90238.15NoNo099
21R:R:L68 R:R:P327 47.26523.28NoNo099
22R:R:I86 R:R:L68 45.61972.85NoNo089
23R:R:I86 R:R:N83 43.96585.66NoYes088
24R:R:M78 R:R:N83 37.267211.22NoYes078
25R:R:H340 R:R:M78 26.77363.94NoNo057
26R:R:F337 R:R:H340 23.607613.58YesNo095
27R:R:F337 R:R:Y331 16.49243.09YesYes097
28L:L:?1 R:R:V131 12.63073.19YesNo108
29R:R:L96 R:R:V131 15.34682.98YesNo078
30L:L:?1 R:R:W284 60.09173.25YesYes108
31R:R:N322 R:R:W284 24.8494.52YesYes198
32R:R:N322 R:R:N326 44.65325.45YesYes199
33R:R:D93 R:R:N326 29.24396.73YesYes199
34R:R:L94 R:R:N65 20.02086.87NoNo079
35R:R:I69 R:R:L94 16.45494.28YesNo077
36R:R:F73 R:R:I69 11.04358.79NoYes047
37R:R:L89 R:R:N326 13.62639.61YesYes199
38R:R:L89 R:R:T137 23.47844.42YesNo097
39R:R:L141 R:R:T137 13.08062.95NoNo097
40R:R:F85 R:R:L141 11.66013.65YesNo089
41R:R:S88 R:R:T137 11.14774.8NoNo097
42L:L:?1 R:R:C221 29.84386.79YesNo005
43R:R:C221 R:R:F225 28.16084.19NoYes056
44R:R:F225 R:R:G132 23.31183.01YesNo267
45R:R:G132 R:R:S175 16.9093.71NoYes278
46R:R:L123 R:R:R127 28.08586.07NoYes056
47R:R:I313 R:R:Y108 11.160210.88NoYes045
48R:R:L123 R:R:V122 17.92132.98NoNo054
49R:R:I118 R:R:V122 16.59243.07NoNo034
50R:R:I118 R:R:K121 15.25524.36NoNo037
51R:R:K121 R:R:S186 13.90966.12NoNo075
52R:R:C120 R:R:S186 12.55575.16NoNo095
53L:L:?1 R:R:Y291 51.093538.46YesNo006
54R:R:S205 R:R:Y291 36.66323.82NoNo046
55R:R:E182 R:R:S205 35.03448.62YesNo054
56R:R:S175 R:R:T129 13.7183.2YesNo285
57R:R:F125 R:R:T129 10.69787.78YesNo265
58R:R:F280 R:R:W284 42.36212.03YesYes198
59R:R:F280 R:R:L230 61.21643.65YesYes096
60R:R:L230 R:R:S234 1003YesNo064
61R:R:S234 R:R:V277 98.39623.23NoNo048
62R:R:V277 R:R:Y237 96.7845.05NoYes089
63R:R:S142 R:R:Y237 86.4326.36YesYes499
64L:L:?1 R:R:H288 43.378521.09YesYes107
65R:R:H288 R:R:Y226 42.42455.44YesYes178
66R:R:L230 R:R:Y226 48.70654.69YesYes068
67R:R:S142 R:R:Y236 81.42475.09YesYes097
68R:R:Y146 R:R:Y236 74.81773.97YesYes087
69R:R:I240 R:R:Y146 58.48783.63NoYes088
70R:R:I240 R:R:V149 56.70074.61NoNo089
71R:R:L244 R:R:V149 55.49262.98YesNo089
72R:R:E182 R:R:Y206 28.17333.37YesYes353
73R:R:P207 R:R:Y206 22.99524.17YesYes333
74R:R:P207 R:R:Y189 16.82574.17YesYes332
75R:R:F191 R:R:Y189 12.69322.06YesYes332
76R:R:L290 R:R:N287 25.74884.12YesYes047
77R:R:H294 R:R:L290 20.591512.86NoYes044
78R:R:H294 R:R:Y293 19.01273.27NoNo045
79R:R:T297 R:R:Y293 17.32568.74NoNo045
80R:R:Q299 R:R:T297 15.63011.42NoNo014
81R:R:Q299 R:R:V302 12.21417.16NoNo011
82R:R:P194 R:R:V302 10.49361.77NoNo011
83R:R:S218 R:R:Y291 13.18897.63NoNo056
84R:R:S218 R:R:S295 18.35456.52NoNo054
85R:R:F296 R:R:S295 11.42682.64NoNo054
86R:R:I269 R:R:L244 21.84544.28NoYes078
87R:R:L244 R:R:R266 25.74052.43YesNo087
88R:R:I251 R:R:R266 21.92886.26YesNo047
89R:R:I269 R:R:L333 19.9752.85NoNo076
90R:R:L333 R:R:T272 18.09625.9NoNo068
91R:R:L276 R:R:T272 12.14331.47NoNo088
92R:R:A329 R:R:L276 10.13964.73NoNo088
93R:R:L97 R:R:S323 16.82154.5NoNo069
94R:R:D93 R:R:L89 12.47668.14YesYes199
95R:R:F280 R:R:N322 21.99966.04YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:C100 5.66 1 Yes No 0 6 0 1
L:L:?1 R:R:V103 3.19 1 Yes No 0 5 0 1
L:L:?1 R:R:R127 8.67 1 Yes Yes 0 6 0 1
L:L:?1 R:R:V131 3.19 1 Yes No 0 8 0 1
L:L:?1 R:R:C221 6.79 1 Yes No 0 5 0 1
L:L:?1 R:R:W284 3.25 1 Yes Yes 0 8 0 1
L:L:?1 R:R:N287 7.84 1 Yes Yes 0 7 0 1
L:L:?1 R:R:H288 21.09 1 Yes Yes 0 7 0 1
L:L:?1 R:R:Y291 38.46 1 Yes No 0 6 0 1
L:L:?1 R:R:A319 3.37 1 Yes No 0 8 0 1
R:R:L96 R:R:R127 4.86 0 Yes Yes 7 6 2 1
R:R:L96 R:R:V131 2.98 0 Yes No 7 8 2 1
R:R:R127 R:R:T99 11.64 1 Yes No 6 6 1 2
R:R:C100 R:R:D104 4.67 0 No Yes 6 6 1 2
R:R:C100 R:R:F320 4.19 0 No Yes 6 7 1 2
R:R:D104 R:R:V103 4.38 1 Yes No 6 5 2 1
R:R:R127 R:R:V103 13.08 1 Yes No 6 5 1 1
R:R:D104 R:R:R316 4.76 1 Yes No 6 5 2 2
R:R:L123 R:R:R127 6.07 0 No Yes 5 6 2 1
R:R:V131 R:R:W284 6.13 1 No Yes 8 8 1 1
R:R:S205 R:R:Y291 3.82 0 No No 4 6 2 1
R:R:S218 R:R:Y291 7.63 0 No No 5 6 2 1
R:R:C221 R:R:F225 4.19 0 No Yes 5 6 1 2
R:R:F222 R:R:Y226 10.32 1 Yes Yes 6 8 2 2
R:R:F222 R:R:H288 7.92 1 Yes Yes 6 7 2 1
R:R:H288 R:R:Y226 5.44 1 Yes Yes 7 8 1 2
R:R:F280 R:R:W284 12.03 1 Yes Yes 9 8 2 1
R:R:F280 R:R:N322 6.04 1 Yes Yes 9 9 2 2
R:R:H288 R:R:W284 7.41 1 Yes Yes 7 8 1 1
R:R:N322 R:R:W284 4.52 1 Yes Yes 9 8 2 1
R:R:L290 R:R:N287 4.12 0 Yes Yes 4 7 2 1
R:R:N287 R:R:S315 5.96 1 Yes No 7 6 1 2
R:R:N287 R:R:R316 8.44 1 Yes No 7 5 1 2
R:R:A319 R:R:N287 4.69 1 No Yes 8 7 1 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8Y53_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.98
Number of Linked Nodes 274
Number of Links 312
Number of Hubs 44
Number of Links mediated by Hubs 165
Number of Communities 9
Number of Nodes involved in Communities 62
Number of Links involved in Communities 80
Path Summary
Number Of Nodes in MetaPath 96
Number Of Links MetaPath 95
Number of Shortest Paths 62447
Length Of Smallest Path 3
Average Path Length 14.5547
Length of Longest Path 36
Minimum Path Strength 1.275
Average Path Strength 6.18685
Maximum Path Strength 29.775
Minimum Path Correlation 0.7
Average Path Correlation 0.934731
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.34783
Average % Of Corr. Nodes 55.4914
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.8543
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • neuropeptide receptor activity   • bombesin receptor activity   • multicellular organismal process   • system process   • circulatory system process   • regulation of blood pressure   • regulation of biological quality   • blood circulation   • behavior   • adult feeding behavior   • adult behavior   • feeding behavior   • monosaccharide metabolic process   • carbohydrate metabolic process   • hexose metabolic process   • small molecule metabolic process   • metabolic process   • primary metabolic process   • glucose metabolic process
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeA1D
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeA1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP32247
Sequence
>8Y53_nogp_Chain_R
LCAIYITYA VIISVGILG NAILIKVFF KTKSMQTVP NIFITSLAF 
GDLLLLLTC VPVDATHYL AEGWLFGRI GCKVLSFIR LTSVGVSVF 
TLTILSADR YKAVVKPLE RQPSNAILK TCVKAGCVW IVSMIFALP 
EAIFSNVYT FRDPNKNMT FESCTSYPV SKKLLQEIH SLLCFLVFY 
IIPLSIISV YYSLIARTL YKSTLNIPT EEQSHARKQ IESRKRIAR 
TVLVLVALF ALCWLPNHL LYLYHSFTS QTYVDPSAM HFIFTIFSR 
VLAFSNSCV NPFALYWLS KSFQKHFKA QL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8Y51APeptideBombesinBB3Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.32025-02-12To be published
8Y51 (No Gprot) APeptideBombesinBB3Homo sapiens--3.32025-02-12To be published
8Y53APeptideBombesinBB3Homo sapiensMK5046-chim(NtGi1-Gs-CtGq)/β1/γ22.932024-09-11doi.org/10.1016/j.celrep.2024.114511
8Y53 (No Gprot) APeptideBombesinBB3Homo sapiensMK5046-2.932024-09-11doi.org/10.1016/j.celrep.2024.114511
8Y52APeptideBombesinBB3Homo sapiensBA1-chim(NtGi1-Gs-CtGq)/β1/γ22.92024-09-1110.1016/j.celrep.2024.114511
8Y52 (No Gprot) APeptideBombesinBB3Homo sapiensBA1-2.92024-09-1110.1016/j.celrep.2024.114511




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8Y53_nogp.zip



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