psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:C100	5.66	Yes	No	0	0	6
2	L:L:?1	R:R:V103	3.19	Yes	No	1	0	5
3	L:L:?1	R:R:R127	8.67	Yes	Yes	1	0	6
4	L:L:?1	R:R:V131	3.19	Yes	No	1	0	8
5	L:L:?1	R:R:C221	6.79	Yes	No	0	0	5
6	L:L:?1	R:R:W284	3.25	Yes	Yes	1	0	8
7	L:L:?1	R:R:N287	7.84	Yes	Yes	1	0	7
8	L:L:?1	R:R:H288	21.09	Yes	Yes	1	0	7
9	L:L:?1	R:R:Y291	38.46	Yes	No	0	0	6
10	L:L:?1	R:R:A319	3.37	Yes	No	1	0	8
11	R:R:C48	R:R:I50	3.27	No	No	0	5	5
12	R:R:C48	R:R:Y51	5.38	No	No	0	5	5
13	R:R:I50	R:R:T53	3.04	No	No	0	5	5
14	R:R:Y108	R:R:Y51	7.94	Yes	No	0	5	5
15	R:R:I58	R:R:Y54	13.3	No	Yes	1	7	7
16	R:R:V101	R:R:Y54	5.05	No	Yes	1	7	7
17	R:R:D104	R:R:Y54	12.64	Yes	Yes	1	6	7
18	R:R:F320	R:R:Y54	6.19	Yes	Yes	1	7	7
19	R:R:S59	R:R:V56	3.23	No	No	0	5	5
20	R:R:I58	R:R:V101	6.14	No	No	1	7	7
21	R:R:F320	R:R:I58	5.02	Yes	No	1	7	7
22	R:R:C324	R:R:G61	3.92	No	No	0	7	8
23	R:R:G64	R:R:L63	3.42	No	No	0	8	4
24	R:R:D93	R:R:N65	8.08	Yes	No	0	9	9
25	R:R:L94	R:R:N65	6.87	No	No	0	7	9
26	R:R:N65	R:R:P327	8.15	No	No	0	9	9
27	R:R:F341	R:R:I67	13.82	No	No	5	6	7
28	R:R:I67	R:R:L345	9.99	No	No	5	7	6
29	R:R:L68	R:R:P327	3.28	No	No	0	9	9
30	R:R:I69	R:R:K70	4.36	Yes	No	0	7	4
31	R:R:F73	R:R:I69	8.79	No	Yes	0	4	7
32	R:R:I69	R:R:L94	4.28	Yes	No	0	7	7
33	R:R:T75	R:R:V71	4.76	Yes	No	6	5	7
34	R:R:H340	R:R:V71	13.84	No	No	0	5	7
35	R:R:Q344	R:R:V71	5.73	No	No	6	5	7
36	R:R:F72	R:R:F73	3.22	No	No	0	7	4
37	R:R:F72	R:R:Q79	3.51	No	No	0	7	7
38	R:R:F72	R:R:T87	19.46	No	No	0	7	6
39	R:R:F73	R:R:F91	5.36	No	No	0	4	6
40	R:R:K74	R:R:Q344	17.63	No	No	0	5	5
41	R:R:S77	R:R:T75	3.2	No	Yes	0	6	5
42	R:R:M78	R:R:T75	3.01	No	Yes	0	7	5
43	R:R:Q344	R:R:T75	5.67	No	Yes	6	5	5
44	R:R:M78	R:R:N83	11.22	No	Yes	0	7	8
45	R:R:H340	R:R:M78	3.94	No	No	0	5	7
46	R:R:P82	R:R:T80	8.74	No	No	7	8	8
47	R:R:N83	R:R:T80	5.85	Yes	No	7	8	8
48	R:R:P82	R:R:V81	3.53	No	No	0	8	6
49	R:R:N83	R:R:P82	3.26	Yes	No	7	8	8
50	R:R:I86	R:R:N83	5.66	No	Yes	0	8	8
51	R:R:I84	R:R:T164	13.68	No	No	0	5	7
52	R:R:C165	R:R:I84	3.27	No	No	0	4	5
53	R:R:F85	R:R:I140	10.05	Yes	No	8	8	6
54	R:R:F85	R:R:L141	3.65	Yes	No	0	8	9
55	R:R:D144	R:R:F85	7.17	No	Yes	8	8	8
56	R:R:F85	R:R:T164	10.38	Yes	No	0	8	7
57	R:R:F91	R:R:T87	5.19	No	No	0	6	6
58	R:R:S88	R:R:T137	4.8	No	No	0	9	7
59	R:R:S88	R:R:W172	3.71	No	No	0	9	9
60	R:R:D93	R:R:L89	8.14	Yes	Yes	1	9	9
61	R:R:L89	R:R:S134	3	Yes	No	1	9	9
62	R:R:L89	R:R:T137	4.42	Yes	No	0	9	7
63	R:R:L138	R:R:L89	6.92	No	Yes	1	8	9
64	R:R:L89	R:R:N326	9.61	Yes	Yes	1	9	9
65	R:R:D93	R:R:S323	5.89	Yes	No	0	9	9
66	R:R:D93	R:R:N326	6.73	Yes	Yes	1	9	9
67	R:R:L96	R:R:R127	4.86	Yes	Yes	0	7	6
68	R:R:L96	R:R:S130	4.5	Yes	No	0	7	8
69	R:R:L96	R:R:V131	2.98	Yes	No	0	7	8
70	R:R:L96	R:R:S323	3	Yes	No	0	7	9
71	R:R:F320	R:R:L97	3.65	Yes	No	0	7	6
72	R:R:L97	R:R:S323	4.5	No	No	0	6	9
73	R:R:I126	R:R:T99	4.56	No	No	0	5	6
74	R:R:R127	R:R:T99	11.64	Yes	No	0	6	6
75	R:R:C100	R:R:D104	4.67	No	Yes	0	6	6
76	R:R:C100	R:R:F320	4.19	No	Yes	0	6	7
77	R:R:P102	R:R:V101	7.07	No	No	0	8	7
78	R:R:D104	R:R:V103	4.38	Yes	No	1	6	5
79	R:R:R127	R:R:V103	13.08	Yes	No	1	6	5
80	R:R:D104	R:R:Y108	3.45	Yes	Yes	1	6	5
81	R:R:D104	R:R:R316	4.76	Yes	No	1	6	5
82	R:R:T106	R:R:W113	7.28	No	Yes	0	5	8
83	R:R:H107	R:R:Y108	13.07	No	Yes	0	5	5
84	R:R:F309	R:R:Y108	4.13	No	Yes	0	4	5
85	R:R:I313	R:R:Y108	10.88	No	Yes	0	4	5
86	R:R:R316	R:R:Y108	3.09	No	Yes	1	5	5
87	R:R:L114	R:R:W113	6.83	No	Yes	0	3	8
88	R:R:G119	R:R:W113	4.22	No	Yes	0	5	8
89	R:R:L123	R:R:W113	7.97	No	Yes	0	5	8
90	R:R:F115	R:R:G116	6.02	No	No	0	6	8
91	R:R:R117	R:R:V188	5.23	No	No	0	3	5
92	R:R:E201	R:R:R117	15.12	No	No	0	5	3
93	R:R:I118	R:R:K121	4.36	No	No	0	3	7
94	R:R:I118	R:R:V122	3.07	No	No	0	3	4
95	R:R:C120	R:R:S186	5.16	No	No	0	9	5
96	R:R:C120	R:R:V188	3.42	No	No	0	9	5
97	R:R:C120	R:R:C203	7.28	No	No	0	9	9
98	R:R:K121	R:R:S186	6.12	No	No	0	7	5
99	R:R:L123	R:R:V122	2.98	No	No	0	5	4
100	R:R:L123	R:R:R127	6.07	No	Yes	0	5	6
101	R:R:E182	R:R:S124	8.62	Yes	No	0	5	5
102	R:R:F125	R:R:T129	7.78	Yes	No	2	6	5
103	R:R:F125	R:R:M176	7.46	Yes	No	2	6	4
104	R:R:A179	R:R:F125	5.55	No	Yes	0	7	6
105	R:R:F125	R:R:L180	4.87	Yes	No	0	6	4
106	R:R:A183	R:R:F125	4.16	No	Yes	0	5	6
107	R:R:E182	R:R:L128	3.98	Yes	No	0	5	5
108	R:R:S175	R:R:T129	3.2	Yes	No	2	8	5
109	R:R:M176	R:R:T129	4.52	No	No	2	4	5
110	R:R:V131	R:R:W284	6.13	No	Yes	1	8	8
111	R:R:F136	R:R:G132	3.01	Yes	No	2	6	7
112	R:R:G132	R:R:S175	3.71	No	Yes	2	7	8
113	R:R:F225	R:R:G132	3.01	Yes	No	2	6	7
114	R:R:V133	R:R:W172	18.39	No	No	0	7	9
115	R:R:S175	R:R:V133	4.85	Yes	No	0	8	7
116	R:R:L138	R:R:S134	3	No	No	1	8	9
117	R:R:P229	R:R:V135	3.53	No	No	0	9	8
118	R:R:F280	R:R:V135	3.93	Yes	No	0	9	8
119	R:R:F136	R:R:V171	6.55	Yes	No	0	6	7
120	R:R:F136	R:R:S175	5.28	Yes	Yes	2	6	8
121	R:R:L138	R:R:N326	4.12	No	Yes	1	8	9
122	R:R:S142	R:R:T139	3.2	Yes	No	4	9	7
123	R:R:I232	R:R:T139	7.6	No	No	0	6	7
124	R:R:I233	R:R:T139	4.56	No	No	4	8	7
125	R:R:D144	R:R:I140	4.2	No	No	8	8	6
126	R:R:I140	R:R:K167	4.36	No	No	0	6	6
127	R:R:I233	R:R:S142	6.19	No	Yes	4	8	9
128	R:R:S142	R:R:Y236	5.09	Yes	Yes	0	9	7
129	R:R:S142	R:R:Y237	6.36	Yes	Yes	4	9	9
130	R:R:R145	R:R:Y237	6.17	No	Yes	0	9	9
131	R:R:V150	R:R:Y146	12.62	No	Yes	0	7	8
132	R:R:Y146	R:R:Y236	3.97	Yes	Yes	0	8	7
133	R:R:L239	R:R:Y146	8.21	No	Yes	0	5	8
134	R:R:I240	R:R:Y146	3.63	No	Yes	0	8	8
135	R:R:I240	R:R:V149	4.61	No	No	0	8	9
136	R:R:T243	R:R:V149	3.17	No	No	0	6	9
137	R:R:L244	R:R:V149	2.98	Yes	No	0	8	9
138	R:R:T243	R:R:V150	6.35	No	No	0	6	7
139	R:R:E154	R:R:K151	12.15	No	No	0	4	6
140	R:R:P157	R:R:Q156	6.32	No	No	0	3	4
141	R:R:N159	R:R:S158	7.45	No	No	0	6	3
142	R:R:F178	R:R:V224	7.87	No	No	2	5	5
143	R:R:F178	R:R:F225	11.79	No	Yes	2	5	6
144	R:R:E182	R:R:S205	8.62	Yes	No	0	5	4
145	R:R:E182	R:R:Y206	3.37	Yes	Yes	3	5	3
146	R:R:E182	R:R:H217	12.31	Yes	No	3	5	6
147	R:R:F185	R:R:I184	7.54	No	No	0	4	5
148	R:R:F185	R:R:Y206	16.5	No	Yes	0	4	3
149	R:R:N187	R:R:Y189	6.98	No	Yes	3	4	2
150	R:R:N187	R:R:P207	13.03	No	Yes	3	4	3
151	R:R:P207	R:R:Y189	4.17	Yes	Yes	3	3	2
152	R:R:F191	R:R:T300	3.89	Yes	No	3	3	2
153	R:R:F191	R:R:Y301	9.28	Yes	No	3	3	2
154	R:R:R192	R:R:T199	3.88	No	No	0	2	5
155	R:R:D193	R:R:P194	6.44	Yes	No	0	1	1
156	R:R:D193	R:R:N195	5.39	Yes	No	0	1	3
157	R:R:D193	R:R:K196	4.15	Yes	No	0	1	3
158	R:R:D193	R:R:D303	5.32	Yes	No	0	1	2
159	R:R:K196	R:R:M198	4.32	No	No	0	3	3
160	R:R:F200	R:R:S202	3.96	No	No	0	2	3
161	R:R:S205	R:R:Y291	3.82	No	No	0	4	6
162	R:R:P207	R:R:Y206	4.17	Yes	Yes	3	3	3
163	R:R:L213	R:R:Y206	10.55	No	Yes	0	4	3
164	R:R:Q214	R:R:Y206	6.76	No	Yes	0	3	3
165	R:R:H217	R:R:Y206	19.6	No	Yes	3	6	3
166	R:R:K210	R:R:P207	5.02	No	Yes	0	4	3
167	R:R:T300	R:R:V208	7.93	No	No	0	2	5
168	R:R:K210	R:R:L213	4.23	No	No	0	4	4
169	R:R:K211	R:R:S298	13.77	No	No	0	2	4
170	R:R:I216	R:R:L212	4.28	No	No	0	5	1
171	R:R:Q214	R:R:S295	5.78	No	No	0	3	4
172	R:R:E215	R:R:F296	18.66	No	No	0	3	5
173	R:R:S218	R:R:Y291	7.63	No	No	0	5	6
174	R:R:L292	R:R:S218	4.5	No	No	0	5	5
175	R:R:S218	R:R:S295	6.52	No	No	0	5	4
176	R:R:C221	R:R:F225	4.19	No	Yes	0	5	6
177	R:R:F222	R:R:Y226	10.32	Yes	Yes	1	6	8
178	R:R:F222	R:R:I227	8.79	Yes	Yes	1	6	4
179	R:R:F222	R:R:H288	7.92	Yes	Yes	1	6	7
180	R:R:F222	R:R:L292	9.74	Yes	No	0	6	5
181	R:R:I227	R:R:L223	4.28	Yes	No	0	4	5
182	R:R:F225	R:R:V224	5.24	Yes	No	2	6	5
183	R:R:I227	R:R:Y226	3.63	Yes	Yes	1	4	8
184	R:R:L230	R:R:Y226	4.69	Yes	Yes	0	6	8
185	R:R:L285	R:R:Y226	10.55	No	Yes	0	6	8
186	R:R:H288	R:R:Y226	5.44	Yes	Yes	1	7	8
187	R:R:I228	R:R:P229	3.39	No	No	0	5	9
188	R:R:L230	R:R:S234	3	Yes	No	0	6	4
189	R:R:F280	R:R:L230	3.65	Yes	Yes	0	9	6
190	R:R:A281	R:R:L230	3.15	No	Yes	0	5	6
191	R:R:I232	R:R:Y236	12.09	No	Yes	0	6	7
192	R:R:I233	R:R:Y237	4.84	No	Yes	4	8	9
193	R:R:S234	R:R:V277	3.23	No	No	0	4	8
194	R:R:V273	R:R:Y237	7.57	No	Yes	0	8	9
195	R:R:V277	R:R:Y237	5.05	No	Yes	0	8	9
196	R:R:L239	R:R:R242	4.86	No	No	0	5	4
197	R:R:I269	R:R:L244	4.28	No	Yes	0	7	8
198	R:R:A270	R:R:L244	3.15	No	Yes	0	7	8
199	R:R:A270	R:R:Y245	4	No	No	0	7	5
200	R:R:R266	R:R:S247	10.54	No	No	0	7	7
201	R:R:I263	R:R:T248	7.6	Yes	No	9	3	4
202	R:R:K267	R:R:T248	6.01	No	No	9	5	4
203	R:R:I251	R:R:P252	3.39	Yes	No	0	4	4
204	R:R:A259	R:R:I251	3.25	No	Yes	0	3	4
205	R:R:I251	R:R:R266	6.26	Yes	No	0	4	7
206	R:R:I263	R:R:T253	3.04	Yes	No	0	3	4
207	R:R:E255	R:R:H258	12.31	No	No	0	1	4
208	R:R:A259	R:R:E255	4.53	No	No	0	3	1
209	R:R:R260	R:R:S257	5.27	No	No	0	3	2
210	R:R:I263	R:R:K267	5.82	Yes	No	9	3	5
211	R:R:R268	R:R:W332	12	No	No	0	7	6
212	R:R:T272	R:R:W332	13.34	No	No	0	8	6
213	R:R:L333	R:R:T272	5.9	No	No	0	6	8
214	R:R:L279	R:R:V275	2.98	No	No	0	7	6
215	R:R:A329	R:R:L276	4.73	No	No	0	8	8
216	R:R:L279	R:R:V325	2.98	No	No	0	7	6
217	R:R:F280	R:R:W284	12.03	Yes	Yes	1	9	8
218	R:R:F280	R:R:N322	6.04	Yes	Yes	1	9	9
219	R:R:C283	R:R:S321	3.44	No	No	0	8	5
220	R:R:H288	R:R:W284	7.41	Yes	Yes	1	7	8
221	R:R:N322	R:R:W284	4.52	Yes	Yes	1	9	8
222	R:R:L285	R:R:P286	3.28	No	No	0	6	9
223	R:R:L285	R:R:L289	8.3	No	No	0	6	6
224	R:R:P286	R:R:S315	7.13	No	No	0	9	6
225	R:R:L318	R:R:P286	3.28	No	No	0	7	9
226	R:R:L290	R:R:N287	4.12	Yes	Yes	0	4	7
227	R:R:N287	R:R:S315	5.96	Yes	No	0	7	6
228	R:R:N287	R:R:R316	8.44	Yes	No	1	7	5
229	R:R:A319	R:R:N287	4.69	No	Yes	1	8	7
230	R:R:H294	R:R:L290	12.86	No	Yes	0	4	4
231	R:R:F311	R:R:L290	4.87	No	Yes	0	5	4
232	R:R:L290	R:R:T312	4.42	Yes	No	0	4	4
233	R:R:H294	R:R:Y293	3.27	No	No	0	4	5
234	R:R:T297	R:R:Y293	8.74	No	No	0	4	5
235	R:R:Q299	R:R:V302	7.16	No	No	0	1	1
236	R:R:P304	R:R:Q299	6.32	No	No	0	1	1
237	R:R:T300	R:R:Y301	12.48	No	No	3	2	2
238	R:R:F311	R:R:H308	10.18	No	No	0	5	3
239	R:R:F311	R:R:S315	7.93	No	No	0	5	6
240	R:R:I313	R:R:V317	3.07	No	No	0	4	5
241	R:R:F314	R:R:L318	13.4	No	No	0	5	7
242	R:R:N322	R:R:N326	5.45	Yes	Yes	1	9	9
243	R:R:F337	R:R:L330	15.83	Yes	No	0	9	9
244	R:R:F337	R:R:Y331	3.09	Yes	Yes	0	9	7
245	R:R:Q338	R:R:Y331	28.18	No	Yes	0	8	7
246	R:R:F341	R:R:Y331	6.19	No	Yes	0	6	7
247	R:R:K342	R:R:Y331	4.78	No	Yes	0	5	7
248	R:R:S334	R:R:S336	3.26	No	No	0	8	6
249	R:R:K335	R:R:Q338	5.42	No	No	0	5	8
250	R:R:F337	R:R:H340	13.58	Yes	No	0	9	5
251	R:R:F341	R:R:L345	3.65	No	No	5	6	6
252	R:R:L141	R:R:T137	2.95	No	No	0	9	7
253	R:R:I161	R:R:I84	2.94	No	No	0	3	5
254	R:R:I251	R:R:I263	2.94	Yes	Yes	0	4	3
255	R:R:I310	R:R:I313	2.94	No	No	0	1	4
256	R:R:I62	R:R:L94	2.85	No	No	0	6	7
257	R:R:I67	R:R:L63	2.85	No	No	0	7	4
258	R:R:I86	R:R:L68	2.85	No	No	0	8	9
259	R:R:I216	R:R:L220	2.85	No	No	0	5	4
260	R:R:I269	R:R:L333	2.85	No	No	0	7	6
261	R:R:G116	R:R:W113	2.81	No	Yes	0	8	8
262	R:R:C324	R:R:F328	2.79	No	No	0	7	7
263	R:R:L95	R:R:L98	2.77	No	No	0	6	4
264	R:R:I251	R:R:Q262	2.74	Yes	No	0	4	4
265	R:R:E215	R:R:K211	2.7	No	No	0	3	2
266	R:R:A143	R:R:Y236	2.67	No	Yes	0	6	7
267	R:R:A241	R:R:Y245	2.67	No	No	0	5	5
268	R:R:F191	R:R:S202	2.64	Yes	No	0	3	3
269	R:R:F296	R:R:S295	2.64	No	No	0	5	4
270	R:R:F337	R:R:S334	2.64	Yes	No	0	9	8
271	R:R:F136	R:R:V174	2.62	Yes	No	0	6	4
272	R:R:V235	R:R:Y236	2.52	No	Yes	0	4	7
273	R:R:F320	R:R:I57	2.51	Yes	No	0	7	8
274	R:R:L244	R:R:R266	2.43	Yes	No	0	8	7
275	R:R:L95	R:R:W172	2.28	No	No	0	6	9
276	R:R:F191	R:R:Y189	2.06	Yes	Yes	3	3	2
277	R:R:A168	R:R:G169	1.95	No	No	0	8	4
278	R:R:A105	R:R:P102	1.87	No	No	0	7	8
279	R:R:G61	R:R:V60	1.84	No	No	0	8	6
280	R:R:G92	R:R:V133	1.84	No	No	0	8	7
281	R:R:G112	R:R:T106	1.82	No	No	0	4	5
282	R:R:P194	R:R:V302	1.77	No	No	0	1	1
283	R:R:G61	R:R:L97	1.71	No	No	0	8	6
284	R:R:A168	R:R:S88	1.71	No	No	0	8	9
285	R:R:C170	R:R:V174	1.71	No	No	0	3	4
286	R:R:A329	R:R:V325	1.7	No	No	0	8	6
287	R:R:K151	R:R:P152	1.67	No	No	0	6	8
288	R:R:L180	R:R:P181	1.64	No	No	0	4	7
289	R:R:S59	R:R:V60	1.62	No	No	0	5	6
290	R:R:A90	R:R:I69	1.62	No	Yes	0	9	7
291	R:R:A241	R:R:L274	1.58	No	No	0	5	5
292	R:R:A281	R:R:L282	1.58	No	No	0	5	6
293	R:R:T190	R:R:T199	1.57	No	No	0	1	5
294	R:R:C283	R:R:N322	1.57	No	Yes	0	8	9
295	R:R:I227	R:R:S231	1.55	Yes	No	0	4	4
296	R:R:I52	R:R:V56	1.54	No	No	0	5	5
297	R:R:K151	R:R:V150	1.52	No	No	0	6	7
298	R:R:I173	R:R:I177	1.47	No	No	0	3	4
299	R:R:L276	R:R:T272	1.47	No	No	0	8	8
300	R:R:Q262	R:R:S265	1.44	No	No	0	4	6
301	R:R:I177	R:R:L180	1.43	No	No	0	4	4
302	R:R:Q299	R:R:T297	1.42	No	No	0	1	4
303	R:R:E201	R:R:T190	1.41	No	No	0	5	1
304	R:R:L109	R:R:L47	1.38	No	No	0	5	3
305	R:R:K147	R:R:Q156	1.36	No	No	0	5	4
306	R:R:E215	R:R:L212	1.33	No	No	0	3	1
307	R:R:R271	R:R:V275	1.31	No	No	0	7	6
308	R:R:E254	R:R:Q256	1.27	No	No	0	4	1
309	R:R:T204	R:R:Y189	1.25	No	Yes	0	4	2
310	R:R:K246	R:R:R242	1.24	No	No	0	4	4
311	R:R:N197	R:R:R192	1.21	No	No	0	5	2
312	R:R:L109	R:R:Y51	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.151	10	1	0
2	R:R:Y54	9.295	4	1	7
3	R:R:I69	4.7625	4	0	7
4	R:R:T75	4.16	4	6	5
5	R:R:N83	6.4975	4	7	8
6	R:R:F85	7.8125	4	8	8
7	R:R:L89	6.418	5	1	9
8	R:R:D93	7.21	4	1	9
9	R:R:L96	3.835	4	0	7
10	R:R:D104	5.98	5	1	6
11	R:R:Y108	7.09333	6	1	5
12	R:R:W113	5.822	5	0	8
13	R:R:F125	5.964	5	2	6
14	R:R:R127	8.864	5	1	6
15	R:R:F136	4.365	4	2	6
16	R:R:S142	5.21	4	4	9
17	R:R:Y146	7.1075	4	0	8
18	R:R:S175	4.26	4	2	8
19	R:R:E182	7.38	5	3	5
20	R:R:Y189	3.615	4	3	2
21	R:R:F191	4.4675	4	3	3
22	R:R:D193	5.325	4	0	1
23	R:R:Y206	10.1583	6	3	3
24	R:R:P207	6.5975	4	3	3
25	R:R:F222	9.1925	4	1	6
26	R:R:F225	6.0575	4	2	6
27	R:R:Y226	6.926	5	1	8
28	R:R:I227	4.5625	4	1	4
29	R:R:L230	3.6225	4	0	6
30	R:R:Y236	5.268	5	0	7
31	R:R:Y237	5.998	5	4	9
32	R:R:L244	3.21	4	0	8
33	R:R:I251	3.716	5	0	4
34	R:R:I263	4.85	4	9	3
35	R:R:F280	6.4125	4	1	9
36	R:R:W284	6.668	5	1	8
37	R:R:N287	6.21	5	1	7
38	R:R:H288	10.465	4	1	7
39	R:R:L290	6.5675	4	0	4
40	R:R:F320	4.312	5	1	7
41	R:R:N322	4.395	4	1	9
42	R:R:N326	6.4775	4	1	9
43	R:R:Y331	10.56	4	0	7
44	R:R:F337	8.785	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:C100	31.3601	5.66	Yes	No	0	0	6
2	R:R:C100	R:R:D104	18.5461	4.67	No	Yes	0	6	6
3	R:R:D104	R:R:Y108	32.1725	3.45	Yes	Yes	1	6	5
4	R:R:Y108	R:R:Y51	22.2662	7.94	Yes	No	0	5	5
5	R:R:C48	R:R:Y51	11.1685	5.38	No	No	0	5	5
6	L:L:?1	R:R:V103	15.5426	3.19	Yes	No	1	0	5
7	R:R:D104	R:R:V103	20.0375	4.38	Yes	No	1	6	5
8	L:L:?1	R:R:N287	43.77	7.84	Yes	Yes	1	0	7
9	R:R:N287	R:R:R316	13.9679	8.44	Yes	No	1	7	5
10	R:R:R316	R:R:Y108	11.7517	3.09	No	Yes	1	5	5
11	R:R:C100	R:R:F320	19.8584	4.19	No	Yes	0	6	7
12	R:R:D104	R:R:Y54	11.6976	12.64	Yes	Yes	1	6	7
13	R:R:F320	R:R:L97	17.8546	3.65	Yes	No	0	7	6
14	R:R:G61	R:R:L97	13.818	1.71	No	No	0	8	6
15	L:L:?1	R:R:R127	34.347	8.67	Yes	Yes	1	0	6
16	R:R:L96	R:R:R127	22.9702	4.86	Yes	Yes	0	7	6
17	R:R:L96	R:R:S323	36.2466	3	Yes	No	0	7	9
18	R:R:D93	R:R:S323	45.9863	5.89	Yes	No	0	9	9
19	R:R:D93	R:R:N65	67.8984	8.08	Yes	No	0	9	9
20	R:R:N65	R:R:P327	48.9023	8.15	No	No	0	9	9
21	R:R:L68	R:R:P327	47.2652	3.28	No	No	0	9	9
22	R:R:I86	R:R:L68	45.6197	2.85	No	No	0	8	9
23	R:R:I86	R:R:N83	43.9658	5.66	No	Yes	0	8	8
24	R:R:M78	R:R:N83	37.2672	11.22	No	Yes	0	7	8
25	R:R:H340	R:R:M78	26.7736	3.94	No	No	0	5	7
26	R:R:F337	R:R:H340	23.6076	13.58	Yes	No	0	9	5
27	R:R:F337	R:R:Y331	16.4924	3.09	Yes	Yes	0	9	7
28	L:L:?1	R:R:V131	12.6307	3.19	Yes	No	1	0	8
29	R:R:L96	R:R:V131	15.3468	2.98	Yes	No	0	7	8
30	L:L:?1	R:R:W284	60.0917	3.25	Yes	Yes	1	0	8
31	R:R:N322	R:R:W284	24.849	4.52	Yes	Yes	1	9	8
32	R:R:N322	R:R:N326	44.6532	5.45	Yes	Yes	1	9	9
33	R:R:D93	R:R:N326	29.2439	6.73	Yes	Yes	1	9	9
34	R:R:L94	R:R:N65	20.0208	6.87	No	No	0	7	9
35	R:R:I69	R:R:L94	16.4549	4.28	Yes	No	0	7	7
36	R:R:F73	R:R:I69	11.0435	8.79	No	Yes	0	4	7
37	R:R:L89	R:R:N326	13.6263	9.61	Yes	Yes	1	9	9
38	R:R:L89	R:R:T137	23.4784	4.42	Yes	No	0	9	7
39	R:R:L141	R:R:T137	13.0806	2.95	No	No	0	9	7
40	R:R:F85	R:R:L141	11.6601	3.65	Yes	No	0	8	9
41	R:R:S88	R:R:T137	11.1477	4.8	No	No	0	9	7
42	L:L:?1	R:R:C221	29.8438	6.79	Yes	No	0	0	5
43	R:R:C221	R:R:F225	28.1608	4.19	No	Yes	0	5	6
44	R:R:F225	R:R:G132	23.3118	3.01	Yes	No	2	6	7
45	R:R:G132	R:R:S175	16.909	3.71	No	Yes	2	7	8
46	R:R:L123	R:R:R127	28.0858	6.07	No	Yes	0	5	6
47	R:R:I313	R:R:Y108	11.1602	10.88	No	Yes	0	4	5
48	R:R:L123	R:R:V122	17.9213	2.98	No	No	0	5	4
49	R:R:I118	R:R:V122	16.5924	3.07	No	No	0	3	4
50	R:R:I118	R:R:K121	15.2552	4.36	No	No	0	3	7
51	R:R:K121	R:R:S186	13.9096	6.12	No	No	0	7	5
52	R:R:C120	R:R:S186	12.5557	5.16	No	No	0	9	5
53	L:L:?1	R:R:Y291	51.0935	38.46	Yes	No	0	0	6
54	R:R:S205	R:R:Y291	36.6632	3.82	No	No	0	4	6
55	R:R:E182	R:R:S205	35.0344	8.62	Yes	No	0	5	4
56	R:R:S175	R:R:T129	13.718	3.2	Yes	No	2	8	5
57	R:R:F125	R:R:T129	10.6978	7.78	Yes	No	2	6	5
58	R:R:F280	R:R:W284	42.362	12.03	Yes	Yes	1	9	8
59	R:R:F280	R:R:L230	61.2164	3.65	Yes	Yes	0	9	6
60	R:R:L230	R:R:S234	100	3	Yes	No	0	6	4
61	R:R:S234	R:R:V277	98.3962	3.23	No	No	0	4	8
62	R:R:V277	R:R:Y237	96.784	5.05	No	Yes	0	8	9
63	R:R:S142	R:R:Y237	86.432	6.36	Yes	Yes	4	9	9
64	L:L:?1	R:R:H288	43.3785	21.09	Yes	Yes	1	0	7
65	R:R:H288	R:R:Y226	42.4245	5.44	Yes	Yes	1	7	8
66	R:R:L230	R:R:Y226	48.7065	4.69	Yes	Yes	0	6	8
67	R:R:S142	R:R:Y236	81.4247	5.09	Yes	Yes	0	9	7
68	R:R:Y146	R:R:Y236	74.8177	3.97	Yes	Yes	0	8	7
69	R:R:I240	R:R:Y146	58.4878	3.63	No	Yes	0	8	8
70	R:R:I240	R:R:V149	56.7007	4.61	No	No	0	8	9
71	R:R:L244	R:R:V149	55.4926	2.98	Yes	No	0	8	9
72	R:R:E182	R:R:Y206	28.1733	3.37	Yes	Yes	3	5	3
73	R:R:P207	R:R:Y206	22.9952	4.17	Yes	Yes	3	3	3
74	R:R:P207	R:R:Y189	16.8257	4.17	Yes	Yes	3	3	2
75	R:R:F191	R:R:Y189	12.6932	2.06	Yes	Yes	3	3	2
76	R:R:L290	R:R:N287	25.7488	4.12	Yes	Yes	0	4	7
77	R:R:H294	R:R:L290	20.5915	12.86	No	Yes	0	4	4
78	R:R:H294	R:R:Y293	19.0127	3.27	No	No	0	4	5
79	R:R:T297	R:R:Y293	17.3256	8.74	No	No	0	4	5
80	R:R:Q299	R:R:T297	15.6301	1.42	No	No	0	1	4
81	R:R:Q299	R:R:V302	12.2141	7.16	No	No	0	1	1
82	R:R:P194	R:R:V302	10.4936	1.77	No	No	0	1	1
83	R:R:S218	R:R:Y291	13.1889	7.63	No	No	0	5	6
84	R:R:S218	R:R:S295	18.3545	6.52	No	No	0	5	4
85	R:R:F296	R:R:S295	11.4268	2.64	No	No	0	5	4
86	R:R:I269	R:R:L244	21.8454	4.28	No	Yes	0	7	8
87	R:R:L244	R:R:R266	25.7405	2.43	Yes	No	0	8	7
88	R:R:I251	R:R:R266	21.9288	6.26	Yes	No	0	4	7
89	R:R:I269	R:R:L333	19.975	2.85	No	No	0	7	6
90	R:R:L333	R:R:T272	18.0962	5.9	No	No	0	6	8
91	R:R:L276	R:R:T272	12.1433	1.47	No	No	0	8	8
92	R:R:A329	R:R:L276	10.1396	4.73	No	No	0	8	8
93	R:R:L97	R:R:S323	16.8215	4.5	No	No	0	6	9
94	R:R:D93	R:R:L89	12.4766	8.14	Yes	Yes	1	9	9
95	R:R:F280	R:R:N322	21.9996	6.04	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:C100	5.66	1	Yes	No	0	6	0	1
L:L:?1	R:R:V103	3.19	1	Yes	No	0	5	0	1
L:L:?1	R:R:R127	8.67	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:V131	3.19	1	Yes	No	0	8	0	1
L:L:?1	R:R:C221	6.79	1	Yes	No	0	5	0	1
L:L:?1	R:R:W284	3.25	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:N287	7.84	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:H288	21.09	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y291	38.46	1	Yes	No	0	6	0	1
L:L:?1	R:R:A319	3.37	1	Yes	No	0	8	0	1
R:R:L96	R:R:R127	4.86	0	Yes	Yes	7	6	2	1
R:R:L96	R:R:V131	2.98	0	Yes	No	7	8	2	1
R:R:R127	R:R:T99	11.64	1	Yes	No	6	6	1	2
R:R:C100	R:R:D104	4.67	0	No	Yes	6	6	1	2
R:R:C100	R:R:F320	4.19	0	No	Yes	6	7	1	2
R:R:D104	R:R:V103	4.38	1	Yes	No	6	5	2	1
R:R:R127	R:R:V103	13.08	1	Yes	No	6	5	1	1
R:R:D104	R:R:R316	4.76	1	Yes	No	6	5	2	2
R:R:L123	R:R:R127	6.07	0	No	Yes	5	6	2	1
R:R:V131	R:R:W284	6.13	1	No	Yes	8	8	1	1
R:R:S205	R:R:Y291	3.82	0	No	No	4	6	2	1
R:R:S218	R:R:Y291	7.63	0	No	No	5	6	2	1
R:R:C221	R:R:F225	4.19	0	No	Yes	5	6	1	2
R:R:F222	R:R:Y226	10.32	1	Yes	Yes	6	8	2	2
R:R:F222	R:R:H288	7.92	1	Yes	Yes	6	7	2	1
R:R:H288	R:R:Y226	5.44	1	Yes	Yes	7	8	1	2
R:R:F280	R:R:W284	12.03	1	Yes	Yes	9	8	2	1
R:R:F280	R:R:N322	6.04	1	Yes	Yes	9	9	2	2
R:R:H288	R:R:W284	7.41	1	Yes	Yes	7	8	1	1
R:R:N322	R:R:W284	4.52	1	Yes	Yes	9	8	2	1
R:R:L290	R:R:N287	4.12	0	Yes	Yes	4	7	2	1
R:R:N287	R:R:S315	5.96	1	Yes	No	7	6	1	2
R:R:N287	R:R:R316	8.44	1	Yes	No	7	5	1	2
R:R:A319	R:R:N287	4.69	1	No	Yes	8	7	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8Y53_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	274
Number of Links	312
Number of Hubs	44
Number of Links mediated by Hubs	165
Number of Communities	9
Number of Nodes involved in Communities	62
Number of Links involved in Communities	80

Path Summary
Number Of Nodes in MetaPath	96
Number Of Links MetaPath	95
Number of Shortest Paths	62447
Length Of Smallest Path	3
Average Path Length	14.5547
Length of Longest Path	36
Minimum Path Strength	1.275
Average Path Strength	6.18685
Maximum Path Strength	29.775
Minimum Path Correlation	0.7
Average Path Correlation	0.934696
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	55.4914
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.8543
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • regulation of biological quality • blood circulation • behavior • adult feeding behavior • adult behavior • feeding behavior • monosaccharide metabolic process • carbohydrate metabolic process • hexose metabolic process • small molecule metabolic process • metabolic process • primary metabolic process • glucose metabolic process • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1D
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32247
Sequence	>8Y53_nogp_Chain_R L C A I Y I T Y A V I I S V G I L G N A I L I K V F F K T K S M Q T V P N I F I T S L A F G D L L L L L T C V P V D A T H Y L A E G W L F G R I G C K V L S F I R L T S V G V S V F T L T I L S A D R Y K A V V K P L E R Q P S N A I L K T C V K A G C V W I V S M I F A L P E A I F S N V Y T F R D P N K N M T F E S C T S Y P V S K K L L Q E I H S L L C F L V F Y I I P L S I I S V Y Y S L I A R T L Y K S T L N I P T E E Q S H A R K Q I E S R K R I A R T V L V L V A L F A L C W L P N H L L Y L Y H S F T S Q T Y V D P S A M H F I F T I F S R V L A F S N S C V N P F A L Y W L S K S F Q K H F K A Q L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8Y52	A	Peptide	Bombesin	BB₃	Homo sapiens	BA1	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-09-11	doi.org/10.1016/j.celrep.2024.114511
	8Y52 (No Gprot)	A	Peptide	Bombesin	BB₃	Homo sapiens	BA1	-		2.9	2024-09-11	doi.org/10.1016/j.celrep.2024.114511
	8Y53	A	Peptide	Bombesin	BB₃	Homo sapiens	MK5046	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.93	2024-09-11	doi.org/10.1016/j.celrep.2024.114511
	8Y53 (No Gprot)	A	Peptide	Bombesin	BB₃	Homo sapiens	MK5046	-		2.93	2024-09-11	doi.org/10.1016/j.celrep.2024.114511
	8Y51	A	Peptide	Bombesin	BB₃	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.3	2025-02-12	To be published
	8Y51 (No Gprot)	A	Peptide	Bombesin	BB₃	Homo sapiens	-	-		3.3	2025-02-12	To be published
	9K07	A	Peptide	Bombesin	BB₃	Homo sapiens	DSO-5a	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.87	2025-08-27	/doi.org/10.1016/j.apsb.2025.06.025
	9K07 (No Gprot)	A	Peptide	Bombesin	BB₃	Homo sapiens	DSO-5a	-		2.87	2025-08-27	/doi.org/10.1016/j.apsb.2025.06.025
	9LWP	A	Peptide	Bombesin	BB₃	Homo sapiens	-	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.93	2025-07-16	doi.org/10.1016/j.apsb.2025.06.025
	9LWP (No Gprot)	A	Peptide	Bombesin	BB₃	Homo sapiens	-	-		2.93	2025-07-16	doi.org/10.1016/j.apsb.2025.06.025

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