psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R127	3.81	Yes	No	0	0	6
2	L:L:?1	R:R:L128	6.5	Yes	No	0	0	5
3	L:L:?1	R:R:V131	5.44	Yes	No	1	0	8
4	L:L:?1	R:R:S205	3.14	Yes	No	0	0	4
5	L:L:?1	R:R:C221	3.31	Yes	No	0	0	5
6	L:L:?1	R:R:W284	3.57	Yes	Yes	1	0	8
7	L:L:?1	R:R:N287	15.77	Yes	No	0	0	7
8	L:L:?1	R:R:H288	8.73	Yes	Yes	1	0	7
9	L:L:?1	R:R:Y291	6.12	Yes	Yes	0	0	6
10	L:L:?1	R:R:R316	11.42	Yes	No	1	0	5
11	R:R:C48	R:R:Y108	5.38	No	Yes	0	5	5
12	R:R:I313	R:R:I50	4.42	No	No	0	4	5
13	R:R:D104	R:R:Y51	4.6	No	No	0	6	5
14	R:R:I58	R:R:Y54	4.84	No	Yes	1	7	7
15	R:R:C100	R:R:Y54	2.69	No	Yes	1	6	7
16	R:R:D104	R:R:Y54	20.69	No	Yes	0	6	7
17	R:R:V317	R:R:Y54	5.05	No	Yes	1	5	7
18	R:R:F320	R:R:Y54	8.25	Yes	Yes	1	7	7
19	R:R:F320	R:R:I57	3.77	Yes	No	0	7	8
20	R:R:I58	R:R:L97	2.85	No	No	0	7	6
21	R:R:F320	R:R:I58	7.54	Yes	No	1	7	7
22	R:R:G61	R:R:V60	3.68	No	Yes	5	8	6
23	R:R:C324	R:R:V60	3.42	No	Yes	5	7	6
24	R:R:F328	R:R:V60	3.93	No	Yes	0	7	6
25	R:R:C324	R:R:G61	3.92	No	No	5	7	8
26	R:R:G64	R:R:L63	3.42	No	No	0	8	4
27	R:R:G64	R:R:I67	3.53	No	No	0	8	7
28	R:R:G64	R:R:P327	4.06	No	No	0	8	9
29	R:R:A90	R:R:N65	3.13	No	No	0	9	9
30	R:R:D93	R:R:N65	16.16	No	No	0	9	9
31	R:R:L94	R:R:N65	5.49	No	No	0	7	9
32	R:R:F341	R:R:I67	5.02	Yes	No	0	6	7
33	R:R:I86	R:R:L68	4.28	No	No	0	8	9
34	R:R:L68	R:R:T87	2.95	No	No	0	9	6
35	R:R:F337	R:R:L68	7.31	No	No	0	9	9
36	R:R:I69	R:R:K70	2.91	No	No	0	7	4
37	R:R:F91	R:R:I69	6.28	No	No	0	6	7
38	R:R:K70	R:R:K74	5.75	No	No	0	4	5
39	R:R:M78	R:R:V71	4.56	Yes	No	2	7	7
40	R:R:H340	R:R:V71	5.54	Yes	No	2	5	7
41	R:R:F72	R:R:F73	4.29	Yes	No	0	7	4
42	R:R:F72	R:R:Q79	5.86	Yes	No	0	7	7
43	R:R:F72	R:R:N83	4.83	Yes	No	0	7	8
44	R:R:F72	R:R:T87	18.16	Yes	No	0	7	6
45	R:R:F73	R:R:F91	4.29	No	No	0	4	6
46	R:R:K74	R:R:Q344	5.42	No	No	0	5	5
47	R:R:S77	R:R:T75	3.2	No	No	2	6	5
48	R:R:M78	R:R:T75	3.01	Yes	No	2	7	5
49	R:R:H340	R:R:T75	8.21	Yes	No	2	5	5
50	R:R:K76	R:R:Q79	2.71	No	No	0	6	7
51	R:R:M78	R:R:S77	3.07	Yes	No	2	7	6
52	R:R:H340	R:R:S77	4.18	Yes	No	2	5	6
53	R:R:M78	R:R:N83	8.41	Yes	No	0	7	8
54	R:R:H340	R:R:M78	9.19	Yes	Yes	2	5	7
55	R:R:T80	R:R:V81	3.17	No	Yes	6	8	6
56	R:R:P82	R:R:T80	6.99	No	No	6	8	8
57	R:R:N83	R:R:T80	4.39	No	No	0	8	8
58	R:R:P82	R:R:V81	3.53	No	Yes	6	8	6
59	R:R:P157	R:R:V81	5.3	No	Yes	0	3	6
60	R:R:T164	R:R:V81	4.76	No	Yes	0	7	6
61	R:R:I84	R:R:T164	7.6	No	No	0	5	7
62	R:R:F85	R:R:T137	5.19	Yes	No	0	8	7
63	R:R:F85	R:R:I140	6.28	Yes	No	0	8	6
64	R:R:F85	R:R:T164	2.59	Yes	No	0	8	7
65	R:R:F85	R:R:K167	3.72	Yes	No	0	8	6
66	R:R:I86	R:R:L141	4.28	No	No	0	8	9
67	R:R:I86	R:R:L330	5.71	No	No	0	8	9
68	R:R:S88	R:R:T137	3.2	No	No	0	9	7
69	R:R:S88	R:R:W172	4.94	No	Yes	0	9	9
70	R:R:L89	R:R:S134	3	Yes	No	0	9	9
71	R:R:L89	R:R:T137	5.9	Yes	No	0	9	7
72	R:R:L138	R:R:L89	4.15	No	Yes	1	8	9
73	R:R:L89	R:R:N326	13.73	Yes	No	1	9	9
74	R:R:G92	R:R:W172	2.81	No	Yes	0	8	9
75	R:R:D93	R:R:L97	8.14	No	No	0	9	6
76	R:R:D93	R:R:S323	8.83	No	No	0	9	9
77	R:R:I126	R:R:L95	2.85	No	No	0	5	6
78	R:R:L96	R:R:S130	4.5	No	No	0	7	8
79	R:R:L96	R:R:S323	3	No	No	0	7	9
80	R:R:I126	R:R:T99	3.04	No	No	0	5	6
81	R:R:R127	R:R:T99	5.17	No	No	0	6	6
82	R:R:C100	R:R:R316	4.18	No	No	1	6	5
83	R:R:C100	R:R:F320	2.79	No	Yes	1	6	7
84	R:R:P102	R:R:V101	3.53	No	No	0	8	7
85	R:R:F115	R:R:P102	2.89	Yes	No	0	6	8
86	R:R:L123	R:R:P102	4.93	No	No	0	5	8
87	R:R:D104	R:R:Y108	5.75	No	Yes	0	6	5
88	R:R:F115	R:R:T106	3.89	Yes	No	0	6	5
89	R:R:L109	R:R:Y108	7.03	No	Yes	0	5	5
90	R:R:G112	R:R:W113	2.81	No	No	0	4	8
91	R:R:R117	R:R:W113	16.99	No	No	0	3	8
92	R:R:F115	R:R:L114	6.09	Yes	No	0	6	3
93	R:R:C120	R:R:F115	4.19	No	Yes	0	9	6
94	R:R:F185	R:R:R117	11.76	No	No	0	4	3
95	R:R:I118	R:R:K121	2.91	No	No	0	3	7
96	R:R:E182	R:R:S124	7.19	No	No	0	5	5
97	R:R:F125	R:R:M176	4.98	No	No	0	6	4
98	R:R:A179	R:R:F125	2.77	No	No	0	7	6
99	R:R:S175	R:R:T129	6.4	No	No	0	8	5
100	R:R:M176	R:R:T129	10.54	No	No	0	4	5
101	R:R:G132	R:R:V131	3.68	No	No	1	7	8
102	R:R:V131	R:R:W284	4.9	No	Yes	1	8	8
103	R:R:F136	R:R:G132	3.01	Yes	No	1	6	7
104	R:R:F225	R:R:G132	4.52	Yes	No	1	6	7
105	R:R:V133	R:R:V171	3.21	No	No	0	7	7
106	R:R:V133	R:R:W172	18.39	No	Yes	0	7	9
107	R:R:S175	R:R:V133	4.85	No	No	0	8	7
108	R:R:F136	R:R:V135	2.62	Yes	No	0	6	8
109	R:R:P229	R:R:V135	3.53	No	No	0	9	8
110	R:R:F280	R:R:V135	3.93	Yes	No	0	9	8
111	R:R:F136	R:R:V174	2.62	Yes	No	1	6	4
112	R:R:F136	R:R:F178	4.29	Yes	No	1	6	5
113	R:R:F136	R:R:V224	2.62	Yes	No	1	6	5
114	R:R:F136	R:R:F225	6.43	Yes	Yes	1	6	6
115	R:R:L138	R:R:N326	5.49	No	No	1	8	9
116	R:R:P229	R:R:T139	3.5	No	No	0	9	7
117	R:R:I232	R:R:T139	6.08	No	No	0	6	7
118	R:R:L141	R:R:R145	9.72	No	No	0	9	9
119	R:R:I233	R:R:S142	7.74	No	No	7	8	9
120	R:R:S142	R:R:Y236	5.09	No	No	0	9	7
121	R:R:S142	R:R:Y237	12.72	No	Yes	7	9	9
122	R:R:A143	R:R:Y236	4	No	No	0	6	7
123	R:R:R145	R:R:Y237	7.2	No	Yes	0	9	9
124	R:R:V150	R:R:Y146	13.88	No	Yes	0	7	8
125	R:R:K151	R:R:Y146	4.78	No	Yes	0	6	8
126	R:R:Y146	R:R:Y236	11.91	Yes	No	0	8	7
127	R:R:L239	R:R:Y146	8.21	No	Yes	0	5	8
128	R:R:I240	R:R:Y146	3.63	No	Yes	0	8	8
129	R:R:V149	R:R:V150	3.21	No	No	0	9	7
130	R:R:I240	R:R:V149	3.07	No	No	0	8	9
131	R:R:L244	R:R:V149	2.98	Yes	No	0	8	9
132	R:R:T243	R:R:V150	14.28	No	No	0	6	7
133	R:R:E154	R:R:K151	4.05	No	No	0	4	6
134	R:R:P157	R:R:Q156	3.16	No	No	0	3	4
135	R:R:A160	R:R:K163	4.82	No	No	0	7	4
136	R:R:C170	R:R:K167	3.23	No	No	0	3	6
137	R:R:G169	R:R:W172	2.81	No	Yes	0	4	9
138	R:R:F178	R:R:V174	2.62	No	No	1	5	4
139	R:R:F178	R:R:V224	3.93	No	No	1	5	5
140	R:R:E182	R:R:S205	2.87	No	No	0	5	4
141	R:R:I184	R:R:Y206	3.63	No	Yes	0	5	3
142	R:R:F185	R:R:P207	5.78	No	No	0	4	3
143	R:R:S205	R:R:Y206	13.99	No	Yes	0	4	3
144	R:R:K210	R:R:Y206	17.91	No	Yes	4	4	3
145	R:R:L213	R:R:Y206	8.21	No	Yes	4	4	3
146	R:R:Q214	R:R:Y206	5.64	Yes	Yes	4	3	3
147	R:R:H217	R:R:Y206	13.07	No	Yes	0	6	3
148	R:R:K210	R:R:L213	14.1	No	No	4	4	4
149	R:R:K210	R:R:Q214	14.92	No	Yes	4	4	3
150	R:R:I216	R:R:L212	2.85	No	No	0	5	1
151	R:R:Q214	R:R:Y291	4.51	Yes	Yes	0	3	6
152	R:R:Q214	R:R:S295	7.22	Yes	No	0	3	4
153	R:R:E215	R:R:L219	3.98	No	No	0	3	5
154	R:R:E215	R:R:S295	2.87	No	No	0	3	4
155	R:R:E215	R:R:F296	8.16	No	No	0	3	5
156	R:R:H217	R:R:Y291	8.71	No	Yes	0	6	6
157	R:R:S218	R:R:Y291	10.17	No	Yes	0	5	6
158	R:R:L292	R:R:S218	7.51	No	No	0	5	5
159	R:R:S218	R:R:S295	6.52	No	No	0	5	4
160	R:R:C221	R:R:F225	2.79	No	Yes	0	5	6
161	R:R:F222	R:R:Y226	5.16	Yes	Yes	1	6	8
162	R:R:F222	R:R:I227	6.28	Yes	No	0	6	4
163	R:R:F222	R:R:H288	5.66	Yes	Yes	1	6	7
164	R:R:F222	R:R:L292	3.65	Yes	No	0	6	5
165	R:R:I227	R:R:L223	4.28	No	No	0	4	5
166	R:R:F225	R:R:V224	2.62	Yes	No	1	6	5
167	R:R:L230	R:R:Y226	7.03	No	Yes	0	6	8
168	R:R:L285	R:R:Y226	8.21	No	Yes	0	6	8
169	R:R:H288	R:R:Y226	8.71	Yes	Yes	1	7	8
170	R:R:I228	R:R:P229	3.39	No	No	0	5	9
171	R:R:I228	R:R:I232	2.94	No	No	0	5	6
172	R:R:F280	R:R:L230	7.31	Yes	No	0	9	6
173	R:R:A281	R:R:L230	3.15	No	No	0	5	6
174	R:R:I233	R:R:Y237	7.25	No	Yes	7	8	9
175	R:R:S234	R:R:V277	3.23	No	No	0	4	8
176	R:R:V273	R:R:Y237	7.57	No	Yes	0	8	9
177	R:R:V277	R:R:Y237	3.79	No	Yes	0	8	9
178	R:R:A241	R:R:L274	3.15	No	No	0	5	5
179	R:R:K246	R:R:T243	3	No	No	0	4	6
180	R:R:L244	R:R:S247	3	Yes	No	3	8	7
181	R:R:L244	R:R:R266	3.64	Yes	Yes	3	8	7
182	R:R:I269	R:R:L244	2.85	No	Yes	0	7	8
183	R:R:K267	R:R:Y245	3.58	No	No	0	5	5
184	R:R:A270	R:R:Y245	6.67	No	No	0	7	5
185	R:R:R266	R:R:S247	5.27	Yes	No	3	7	7
186	R:R:I263	R:R:T248	6.08	Yes	No	0	3	4
187	R:R:I251	R:R:P252	3.39	Yes	No	0	4	4
188	R:R:I251	R:R:Q262	9.61	Yes	No	3	4	4
189	R:R:I251	R:R:I263	10.3	Yes	Yes	0	4	3
190	R:R:I251	R:R:R266	7.52	Yes	Yes	3	4	7
191	R:R:A259	R:R:P252	3.74	No	No	0	3	4
192	R:R:E254	R:R:T253	4.23	No	No	0	4	4
193	R:R:R260	R:R:T253	5.17	No	No	0	3	4
194	R:R:Q256	R:R:R260	4.67	No	No	0	1	3
195	R:R:Q262	R:R:R266	3.5	No	Yes	3	4	7
196	R:R:R268	R:R:S265	2.64	No	No	0	7	6
197	R:R:K267	R:R:R271	3.71	No	No	0	5	7
198	R:R:I269	R:R:L333	2.85	No	No	0	7	6
199	R:R:L276	R:R:T272	2.95	No	No	0	8	8
200	R:R:L333	R:R:T272	11.79	No	No	0	6	8
201	R:R:A329	R:R:L276	4.73	No	No	0	8	8
202	R:R:L279	R:R:V325	4.47	No	No	0	7	6
203	R:R:F280	R:R:W284	7.02	Yes	Yes	1	9	8
204	R:R:F280	R:R:N322	6.04	Yes	Yes	1	9	9
205	R:R:C283	R:R:S321	3.44	No	No	0	8	5
206	R:R:C283	R:R:N322	3.15	No	Yes	0	8	9
207	R:R:H288	R:R:W284	4.23	Yes	Yes	1	7	8
208	R:R:A319	R:R:W284	2.59	No	Yes	0	8	8
209	R:R:N322	R:R:W284	6.78	Yes	Yes	1	9	8
210	R:R:L285	R:R:P286	3.28	No	No	0	6	9
211	R:R:L285	R:R:L289	8.3	No	No	0	6	6
212	R:R:P286	R:R:S315	3.56	No	No	0	9	6
213	R:R:L318	R:R:P286	4.93	No	No	0	7	9
214	R:R:N287	R:R:S315	4.47	No	No	0	7	6
215	R:R:A319	R:R:N287	4.69	No	No	0	8	7
216	R:R:H294	R:R:L290	5.14	No	Yes	0	4	4
217	R:R:L290	R:R:T312	7.37	Yes	No	0	4	4
218	R:R:L290	R:R:S315	4.5	Yes	No	0	4	6
219	R:R:F296	R:R:L292	3.65	No	No	0	5	5
220	R:R:H294	R:R:H308	7.17	No	Yes	0	4	3
221	R:R:H308	R:R:T312	6.85	Yes	No	0	3	4
222	R:R:I313	R:R:V317	3.07	No	No	0	4	5
223	R:R:F314	R:R:L318	13.4	No	No	0	5	7
224	R:R:F320	R:R:R316	3.21	Yes	No	1	7	5
225	R:R:F320	R:R:V317	7.87	Yes	No	1	7	5
226	R:R:L318	R:R:S321	3	No	No	0	7	5
227	R:R:N322	R:R:N326	5.45	Yes	No	1	9	9
228	R:R:Q338	R:R:Y331	6.76	No	No	0	8	7
229	R:R:F341	R:R:Y331	11.35	Yes	No	0	6	7
230	R:R:F337	R:R:S334	2.64	No	No	0	9	8
231	R:R:H340	R:R:S336	4.18	Yes	No	0	5	6
232	R:R:K339	R:R:Q338	2.71	No	No	0	4	8
233	R:R:K342	R:R:Q338	4.07	No	No	0	5	8
234	R:R:F341	R:R:K342	3.72	Yes	No	0	6	5
235	R:R:F341	R:R:L345	6.09	Yes	No	0	6	6
236	R:R:E254	R:R:E255	2.54	No	No	0	4	1
237	R:R:I263	R:R:R260	2.51	Yes	No	0	3	3
238	R:R:F311	R:R:L290	2.44	No	Yes	0	5	4
239	R:R:T272	R:R:W332	2.43	No	No	0	8	6
240	R:R:D144	R:R:F85	2.39	No	Yes	0	8	8
241	R:R:F309	R:R:Y108	2.06	No	Yes	0	4	5
242	R:R:F337	R:R:Y331	2.06	No	No	0	9	7
243	R:R:R268	R:R:W332	2	No	No	0	7	6
244	R:R:G119	R:R:V122	1.84	No	No	0	5	4
245	R:R:A241	R:R:A270	1.79	No	No	0	5	7
246	R:R:G61	R:R:L97	1.71	No	No	0	8	6
247	R:R:A168	R:R:S88	1.71	No	No	0	8	9
248	R:R:K151	R:R:P152	1.67	No	No	0	6	8
249	R:R:C165	R:R:I84	1.64	No	No	0	4	5
250	R:R:C165	R:R:I161	1.64	No	No	0	4	3
251	R:R:L180	R:R:P181	1.64	No	No	0	4	7
252	R:R:S234	R:R:S238	1.63	No	No	0	4	4
253	R:R:S59	R:R:V60	1.62	No	Yes	0	5	6
254	R:R:S209	R:R:V208	1.62	No	No	0	4	5
255	R:R:V56	R:R:V60	1.6	No	Yes	0	5	6
256	R:R:C283	R:R:L279	1.59	No	No	0	8	7
257	R:R:A270	R:R:L244	1.58	No	Yes	0	7	8
258	R:R:I227	R:R:S231	1.55	No	No	0	4	4
259	R:R:I126	R:R:V122	1.54	No	No	0	5	4
260	R:R:H217	R:R:P181	1.53	No	No	0	6	7
261	R:R:I57	R:R:T53	1.52	No	No	0	8	5
262	R:R:F115	R:R:G116	1.51	Yes	No	0	6	8
263	R:R:F115	R:R:G119	1.51	Yes	No	0	6	5
264	R:R:L239	R:R:V235	1.49	No	No	0	5	4
265	R:R:L279	R:R:V275	1.49	No	No	0	7	6
266	R:R:I173	R:R:I177	1.47	No	No	0	3	4
267	R:R:I62	R:R:L63	1.43	No	No	0	6	4
268	R:R:I62	R:R:L94	1.43	No	No	0	6	7
269	R:R:I177	R:R:L180	1.43	No	No	0	4	4
270	R:R:P207	R:R:Y206	1.39	No	Yes	0	3	3
271	R:R:H308	R:R:S305	1.39	Yes	No	0	3	2
272	R:R:A241	R:R:R242	1.38	No	No	0	5	4
273	R:R:H107	R:R:T106	1.37	No	No	0	5	5
274	R:R:E264	R:R:I263	1.37	No	Yes	0	4	3
275	R:R:E154	R:R:K147	1.35	No	No	0	4	5
276	R:R:A55	R:R:Y51	1.33	No	No	0	6	5
277	R:R:E154	R:R:L153	1.33	No	No	0	4	6
278	R:R:R127	R:R:V103	1.31	No	No	0	6	5
279	R:R:H308	R:R:M307	1.31	Yes	No	0	3	3
280	R:R:K335	R:R:R268	1.24	No	No	0	5	7
281	R:R:I52	R:R:Y51	1.21	No	No	0	5	5
282	R:R:H294	R:R:Y293	1.09	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.781	10	1	0
2	R:R:Y54	8.304	5	1	7
3	R:R:V60	2.85	5	5	6
4	R:R:F72	8.285	4	0	7
5	R:R:M78	5.648	5	2	7
6	R:R:V81	4.19	4	6	6
7	R:R:F85	4.034	5	0	8
8	R:R:L89	6.695	4	1	9
9	R:R:Y108	5.055	4	0	5
10	R:R:F115	3.34667	6	0	6
11	R:R:F136	3.59833	6	1	6
12	R:R:Y146	8.482	5	0	8
13	R:R:W172	7.2375	4	0	9
14	R:R:Y206	9.12	7	4	3
15	R:R:Q214	8.0725	4	4	3
16	R:R:F222	5.1875	4	1	6
17	R:R:F225	4.09	4	1	6
18	R:R:Y226	7.2775	4	1	8
19	R:R:Y237	7.706	5	7	9
20	R:R:L244	2.81	5	3	8
21	R:R:I251	7.705	4	3	4
22	R:R:I263	5.065	4	0	3
23	R:R:R266	4.9825	4	3	7
24	R:R:F280	6.075	4	1	9
25	R:R:W284	4.84833	6	1	8
26	R:R:H288	6.8325	4	1	7
27	R:R:L290	4.8625	4	0	4
28	R:R:Y291	7.3775	4	0	6
29	R:R:H308	4.18	4	0	3
30	R:R:F320	5.57167	6	1	7
31	R:R:N322	5.355	4	1	9
32	R:R:H340	6.26	5	2	5
33	R:R:F341	6.545	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R316	39.1513	11.42	Yes	No	1	0	5
2	R:R:D104	R:R:Y54	17.8592	20.69	No	Yes	0	6	7
3	R:R:F320	R:R:R316	31.0378	3.21	Yes	No	1	7	5
4	R:R:F320	R:R:I58	23.6034	7.54	Yes	No	1	7	7
5	R:R:I58	R:R:L97	31.5221	2.85	No	No	0	7	6
6	R:R:D93	R:R:L97	30.1953	8.14	No	No	0	9	6
7	R:R:D93	R:R:N65	29.374	16.16	No	No	0	9	9
8	R:R:L94	R:R:N65	28.9633	5.49	No	No	0	7	9
9	R:R:I62	R:R:L94	28.779	1.43	No	No	0	6	7
10	R:R:I62	R:R:L63	28.6316	1.43	No	No	0	6	4
11	R:R:G64	R:R:L63	28.5684	3.42	No	No	0	8	4
12	R:R:G64	R:R:I67	28.5684	3.53	No	No	0	8	7
13	R:R:F341	R:R:I67	28.5789	5.02	Yes	No	0	6	7
14	L:L:?1	R:R:W284	62.2545	3.57	Yes	Yes	1	0	8
15	R:R:N322	R:R:W284	78.9238	6.78	Yes	Yes	1	9	8
16	R:R:N322	R:R:N326	94.7454	5.45	Yes	No	1	9	9
17	R:R:L89	R:R:N326	93.8135	13.73	Yes	No	1	9	9
18	R:R:L89	R:R:T137	94.4032	5.9	Yes	No	0	9	7
19	R:R:F85	R:R:T137	92.4183	5.19	Yes	No	0	8	7
20	R:R:F85	R:R:T164	91.3652	2.59	Yes	No	0	8	7
21	R:R:T164	R:R:V81	90.2701	4.76	No	Yes	0	7	6
22	R:R:T80	R:R:V81	88.4221	3.17	No	Yes	6	8	6
23	R:R:N83	R:R:T80	88.7853	4.39	No	No	0	8	8
24	R:R:F72	R:R:N83	86.832	4.83	Yes	No	0	7	8
25	R:R:F72	R:R:T87	83.9415	18.16	Yes	No	0	7	6
26	R:R:L68	R:R:T87	83.7624	2.95	No	No	0	9	6
27	R:R:I86	R:R:L68	100	4.28	No	No	0	8	9
28	R:R:F341	R:R:Y331	27.2785	11.35	Yes	No	0	6	7
29	R:R:F337	R:R:Y331	28.5632	2.06	No	No	0	9	7
30	R:R:I86	R:R:L141	98.589	4.28	No	No	0	8	9
31	R:R:S88	R:R:T137	18.8227	3.2	No	No	0	9	7
32	R:R:S88	R:R:W172	15.79	4.94	No	Yes	0	9	9
33	L:L:?1	R:R:R127	23.377	3.81	Yes	No	0	0	6
34	R:R:R127	R:R:T99	20.834	5.17	No	No	0	6	6
35	R:R:I126	R:R:T99	19.3914	3.04	No	No	0	5	6
36	R:R:I126	R:R:V122	16.464	1.54	No	No	0	5	4
37	R:R:G119	R:R:V122	14.9897	1.84	No	No	0	5	4
38	R:R:F115	R:R:G119	13.505	1.51	Yes	No	0	6	5
39	L:L:?1	R:R:S205	16.8641	3.14	Yes	No	0	0	4
40	R:R:S205	R:R:Y206	12.9363	13.99	No	Yes	0	4	3
41	R:R:V133	R:R:W172	11.162	18.39	No	Yes	0	7	9
42	R:R:F280	R:R:V135	13.6998	3.93	Yes	No	0	9	8
43	R:R:L141	R:R:R145	97.894	9.72	No	No	0	9	9
44	R:R:R145	R:R:Y237	97.1884	7.2	No	Yes	0	9	9
45	R:R:S142	R:R:Y237	92.3182	12.72	No	Yes	7	9	9
46	R:R:S142	R:R:Y236	91.9549	5.09	No	No	0	9	7
47	R:R:Y146	R:R:Y236	90.3649	11.91	Yes	No	0	8	7
48	R:R:V150	R:R:Y146	42.9211	13.88	No	Yes	0	7	8
49	R:R:I240	R:R:Y146	40.6887	3.63	No	Yes	0	8	8
50	R:R:V149	R:R:V150	39.8094	3.21	No	No	0	9	7
51	R:R:I240	R:R:V149	39.6041	3.07	No	No	0	8	9
52	R:R:L244	R:R:V149	77.0073	2.98	Yes	No	0	8	9
53	L:L:?1	R:R:Y291	21.4079	6.12	Yes	Yes	0	0	6
54	R:R:F222	R:R:H288	10.3459	5.66	Yes	Yes	1	6	7
55	R:R:A270	R:R:L244	18.2436	1.58	No	Yes	0	7	8
56	R:R:L244	R:R:R266	33.644	3.64	Yes	Yes	3	8	7
57	R:R:I251	R:R:R266	28.8053	7.52	Yes	Yes	3	4	7
58	R:R:I251	R:R:I263	21.1236	10.3	Yes	Yes	0	4	3
59	R:R:I263	R:R:R260	13.2891	2.51	Yes	No	0	3	3
60	R:R:I269	R:R:L244	23.2296	2.85	No	Yes	0	7	8
61	R:R:I269	R:R:L333	20.9077	2.85	No	No	0	7	6
62	R:R:L333	R:R:T272	18.5226	11.79	No	No	0	6	8
63	R:R:T272	R:R:W332	10.6408	2.43	No	No	0	8	6
64	R:R:A319	R:R:W284	11.6043	2.59	No	Yes	0	8	8
65	L:L:?1	R:R:N287	20.3601	15.77	Yes	No	0	0	7
66	R:R:A319	R:R:N287	10.7355	4.69	No	No	0	8	7
67	R:R:N287	R:R:S315	27.826	4.47	No	No	0	7	6
68	R:R:L290	R:R:S315	25.1145	4.5	Yes	No	0	4	6
69	R:R:H294	R:R:L290	11.4516	5.14	No	Yes	0	4	4
70	R:R:F337	R:R:L68	29.9531	7.31	No	No	0	9	9
71	R:R:F280	R:R:N322	13.247	6.04	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:R127	3.81	1	Yes	No	0	6	0	1
L:L:?1	R:R:L128	6.5	1	Yes	No	0	5	0	1
L:L:?1	R:R:V131	5.44	1	Yes	No	0	8	0	1
L:L:?1	R:R:S205	3.14	1	Yes	No	0	4	0	1
L:L:?1	R:R:C221	3.31	1	Yes	No	0	5	0	1
L:L:?1	R:R:W284	3.57	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:N287	15.77	1	Yes	No	0	7	0	1
L:L:?1	R:R:H288	8.73	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y291	6.12	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:R316	11.42	1	Yes	No	0	5	0	1
R:R:R127	R:R:T99	5.17	0	No	No	6	6	1	2
R:R:C100	R:R:R316	4.18	1	No	No	6	5	2	1
R:R:C100	R:R:F320	2.79	1	No	Yes	6	7	2	2
R:R:G132	R:R:V131	3.68	1	No	No	7	8	2	1
R:R:V131	R:R:W284	4.9	1	No	Yes	8	8	1	1
R:R:F225	R:R:G132	4.52	1	Yes	No	6	7	2	2
R:R:E182	R:R:S205	2.87	0	No	No	5	4	2	1
R:R:S205	R:R:Y206	13.99	0	No	Yes	4	3	1	2
R:R:Q214	R:R:Y206	5.64	4	Yes	Yes	3	3	2	2
R:R:H217	R:R:Y206	13.07	0	No	Yes	6	3	2	2
R:R:Q214	R:R:Y291	4.51	4	Yes	Yes	3	6	2	1
R:R:H217	R:R:Y291	8.71	0	No	Yes	6	6	2	1
R:R:S218	R:R:Y291	10.17	0	No	Yes	5	6	2	1
R:R:C221	R:R:F225	2.79	0	No	Yes	5	6	1	2
R:R:F222	R:R:Y226	5.16	1	Yes	Yes	6	8	2	2
R:R:F222	R:R:H288	5.66	1	Yes	Yes	6	7	2	1
R:R:H288	R:R:Y226	8.71	1	Yes	Yes	7	8	1	2
R:R:F280	R:R:W284	7.02	1	Yes	Yes	9	8	2	1
R:R:F280	R:R:N322	6.04	1	Yes	Yes	9	9	2	2
R:R:H288	R:R:W284	4.23	1	Yes	Yes	7	8	1	1
R:R:A319	R:R:W284	2.59	0	No	Yes	8	8	2	1
R:R:N322	R:R:W284	6.78	1	Yes	Yes	9	8	2	1
R:R:N287	R:R:S315	4.47	0	No	No	7	6	1	2
R:R:A319	R:R:N287	4.69	0	No	No	8	7	2	1
R:R:F320	R:R:R316	3.21	1	Yes	No	7	5	2	1
R:R:R127	R:R:V103	1.31	0	No	No	6	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9K07_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.59
Number of Linked Nodes	247
Number of Links	282
Number of Hubs	33
Number of Links mediated by Hubs	139
Number of Communities	7
Number of Nodes involved in Communities	46
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	42966
Length Of Smallest Path	3
Average Path Length	17.4208
Length of Longest Path	39
Minimum Path Strength	1.27
Average Path Strength	6.06177
Maximum Path Strength	15.95
Minimum Path Correlation	0.7
Average Path Correlation	0.925092
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	44.9024
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.1549
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • bombesin receptor activity • oxidoreductase activity • monooxygenase activity • Oplophorus-luciferin 2-monooxygenase activity • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen • catalytic activity • luciferin monooxygenase activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • multicellular organismal process • system process • circulatory system process • regulation of blood pressure
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • regulation of biological quality • blood circulation • behavior • adult feeding behavior • adult behavior • feeding behavior • monosaccharide metabolic process • carbohydrate metabolic process • hexose metabolic process • small molecule metabolic process • metabolic process • primary metabolic process • glucose metabolic process • bioluminescence • cell periphery • cellular anatomical structure • plasma membrane • membrane • extracellular region • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • D1 dopamine receptor binding • dopamine receptor binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cell population proliferation • positive regulation of cell population proliferation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • renal system process • positive regulation of urine volume • regulation of urine volume • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to nitrogen compound • cellular response to acetylcholine • response to oxygen-containing compound • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • response to nutrient levels • response to nutrient • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • response to hormone • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • regulation of protein transport • protein secretion • regulation of protein secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • synapse • cell junction • hippocampal mossy fiber to CA3 synapse • cell body • cilium • ciliary basal body • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • organelle membrane • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • response to hypoxia • response to oxygen levels • response to abiotic stimulus • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • cardiac muscle cell apoptotic process • photoreceptor inner segment • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • cell projection membrane • G-protein beta-subunit binding
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1E
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1E
Name	(R)-tacrine(10)-hupyridone
Synonyms	(R)-N-9 -(1 ,2 ,3 ,4 -TETRAHYDROACRIDINYL)-N'-5 -[5 ,6 ,7 ,8 -TETRAHYDRO-2'(1'H)-QUINOLINONYL]-1,10-DIAMINODECANE; (R)-TACRINE(10)-HUPYRIDONE
Identifier
Formula	C32 H44 N4 O
Molecular Weight	500.718
SMILES
PubChem	5287575
Formal Charge	0
Total Atoms	81
Total Chiral Atoms	1
Total Bonds	85
Total Aromatic Bonds	17


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32247
Sequence	>9K07_nogp_Chain_R C A I Y I T Y A V I I S V G I L G N A I L I K V F F K T K S M Q T V P N I F I T S L A F G D L L L L L T C V P V D A T H Y L A E G W L F G R I G C K V L S F I R L T S V G V S V F T L T I L S A D R Y K A V V K P L E R Q P S N A I L K T C V K A G C V W I V S M I F A L P E A I F T S Y P V S K K L L Q E I H S L L C F L V F Y I I P L S I I S V Y Y S L I A R T L Y K S T L N I P T E E Q S H A R K Q I E S R K R I A R T V L V L V A L F A L C W L P N H L L Y L Y H S F T S A M H F I F T I F S R V L A F S N S C V N P F A L Y W L S K S F Q K H F K A Q L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8Y52	A	Peptide	Bombesin	BB₃	Homo sapiens	BA1	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-09-11	doi.org/10.1016/j.celrep.2024.114511
	8Y52 (No Gprot)	A	Peptide	Bombesin	BB₃	Homo sapiens	BA1	-		2.9	2024-09-11	doi.org/10.1016/j.celrep.2024.114511
	8Y53	A	Peptide	Bombesin	BB₃	Homo sapiens	MK5046	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.93	2024-09-11	doi.org/10.1016/j.celrep.2024.114511
	8Y53 (No Gprot)	A	Peptide	Bombesin	BB₃	Homo sapiens	MK5046	-		2.93	2024-09-11	doi.org/10.1016/j.celrep.2024.114511
	8Y51	A	Peptide	Bombesin	BB₃	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.3	2025-02-12	To be published
	8Y51 (No Gprot)	A	Peptide	Bombesin	BB₃	Homo sapiens	-	-		3.3	2025-02-12	To be published
	9K07	A	Peptide	Bombesin	BB₃	Homo sapiens	DSO-5a	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.87	2025-08-27	/doi.org/10.1016/j.apsb.2025.06.025
	9K07 (No Gprot)	A	Peptide	Bombesin	BB₃	Homo sapiens	DSO-5a	-		2.87	2025-08-27	/doi.org/10.1016/j.apsb.2025.06.025
	9LWP	A	Peptide	Bombesin	BB₃	Homo sapiens	-	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.93	2025-07-16	doi.org/10.1016/j.apsb.2025.06.025
	9LWP (No Gprot)	A	Peptide	Bombesin	BB₃	Homo sapiens	-	-		2.93	2025-07-16	doi.org/10.1016/j.apsb.2025.06.025

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9K07_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.