Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:R38 5.685164
2A:A:E209 10.2425419
3A:A:F219 7.638336178
4A:A:M221 5.5725408
5A:A:F222 12.802517
6A:A:K233 6.11419
7A:A:W234 7.356509
8A:A:F238 8.81519
9A:A:I245 4.8925447
10A:A:F246 4.6875409
11A:A:D249 7.9325408
12A:A:Y253 6.4325408
13A:A:R265 6.81254199
14A:A:L270 7.16406
15A:A:F273 5.166559
16A:A:W277 8.692556
17A:A:W281 11.884515
18A:A:I288 6.32449
19A:A:F290 5.91833649
20A:A:L291 4.6325458
21A:A:N292 3.806549
22A:A:I308 7.23407
23A:A:F312 7.5025408
24A:A:F315 12.834126
25A:A:F340 10.9665127
26A:A:K343 5.51254123
27A:A:F345 6.706558
28A:A:I358 6.9494
29A:A:Y360 11.078598
30A:A:F363 7.585455
31A:A:D368 6.1825449
32A:A:N371 8.24449
33A:A:F376 5.821676178
34A:A:I383 3.818508
35A:A:Q385 7.4225495
36B:B:L14 3.775408
37B:B:L30 4.675405
38B:B:T34 5.22425
39B:B:I37 4.865422
40B:B:V40 5.0375423
41B:B:H54 10.4525119
42B:B:K57 12.4575419
43B:B:Y59 8.114518
44B:B:W63 6.235607
45B:B:D76 8.884169
46B:B:I80 8.99754118
47B:B:W82 9.781676119
48B:B:K89 5.0545119
49B:B:I93 5.65407
50B:B:L95 4.3175408
51B:B:W99 8.33625819
52B:B:M101 5.262519
53B:B:Y105 4.285717206
54B:B:N110 6.194134
55B:B:Y111 6.65134
56B:B:Y124 5.01333606
57B:B:H142 7.61667679
58B:B:Y145 5.11833618
59B:B:C149 3.84478
60B:B:F151 4.6875409
61B:B:I157 4.3725407
62B:B:T159 5.79579
63B:B:D163 7.816579
64B:B:L168 4.99406
65B:B:W169 9.88833678
66B:B:Q176 8.085474
67B:B:F180 8.718567
68B:B:H183 9.664569
69B:B:V187 4.3775469
70B:B:F199 9.68469
71B:B:V200 7.625436
72B:B:D205 6.824569
73B:B:K209 10.6825466
74B:B:L210 5.454505
75B:B:W211 10.21568
76B:B:C218 6.7465
77B:B:Q220 7.3625437
78B:B:F222 8.0675438
79B:B:H225 9.836149
80B:B:F235 7.16616
81B:B:P236 6.015417
82B:B:N237 6.7375405
83B:B:F241 7.992536
84B:B:D247 6.9125149
85B:B:F253 7.635436
86B:B:D254 3.84409
87B:B:D258 8.65537
88B:B:Q259 5.1025436
89B:B:E260 7.2875406
90B:B:Y264 6.22515
91B:B:C271 4.6075415
92B:B:F278 5.87617
93B:B:R283 8.04167629
94B:B:L285 5.555416
95B:B:Y289 7.46333617
96B:B:D290 5.265416
97B:B:N295 7.925416
98B:B:W297 4.808518
99B:B:K301 5.11405
100B:B:L308 7.7575427
101B:B:H311 9.618529
102B:B:R314 10.164518
103B:B:T321 6.70254217
104B:B:W332 11.7343719
105B:B:D333 9.06429
106B:B:W339 8.47529
107G:G:E22 7.14469
108G:G:R27 6.59638
109G:G:D48 5.972529
110G:G:L50 4.636529
111G:G:L51 3.7825426
112G:G:P60 6.68489
113G:G:F61 5.67333988
114R:R:Y54 11.87754107
115R:R:F72 8.1875407
116R:R:V81 4.6225406
117R:R:F85 6.302508
118R:R:L97 6.3565106
119R:R:Y146 10.025408
120R:R:E182 7.0075405
121R:R:Y206 8.622503
122R:R:Q214 3.6475403
123R:R:F222 6.2654276
124R:R:F225 4.5406
125R:R:Y226 7.23254278
126R:R:Y237 7.108509
127R:R:I251 4.854594
128R:R:P252 4.755494
129R:R:H258 5.2025404
130R:R:Q262 7.85494
131R:R:R266 5.71143797
132R:R:W284 5.664268
133R:R:F320 7.636676107
134R:R:N322 6.2954269
135R:R:Y331 7.595407
136R:R:F337 4.705409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:F222 A:A:R42 10.53184.28YesNo079
2B:B:S97 B:B:W99 70.76463.71NoYes089
3B:B:D118 B:B:S97 70.506710.31NoNo098
4B:B:D118 B:B:I120 70.25574.2NoNo096
5B:B:E138 B:B:I120 69.51984.1NoNo066
6B:B:E138 B:B:S122 34.63948.62NoNo068
7B:B:S122 B:B:Y124 34.36015.09NoYes086
8B:B:V112 B:B:Y124 60.18433.79NoYes086
9B:B:E138 B:B:V135 34.63947.13NoNo064
10B:B:V135 B:B:Y124 34.36015.05NoYes046
11A:A:F238 B:B:W99 57.938911.02YesYes199
12A:A:F238 A:A:W234 54.3364.01YesYes099
13A:A:R231 A:A:W234 99.95987NoYes099
14A:A:D272 A:A:R231 10010.72NoNo089
15A:A:D272 A:A:F246 99.79755.97NoYes089
16A:A:F246 A:A:L289 84.19493.65YesNo099
17A:A:L289 A:A:L291 76.47395.54NoYes598
18A:A:F363 A:A:L291 78.10194.87YesYes558
19A:A:F363 A:A:R342 77.16829.62YesNo054
20A:A:P361 A:A:R342 76.95498.65NoNo054
21A:A:P361 R:R:P252 81.26873.9NoYes054
22A:A:Y360 R:R:P252 23.5098.34YesYes984
23A:A:D378 A:A:Y360 19.920919.54NoYes078
24A:A:D378 A:A:I288 11.082312.59NoYes079
25A:A:F238 A:A:L44 10.25119.49YesNo099
26A:A:N292 A:A:T364 11.6815.85YesNo499
27A:A:F290 A:A:T364 12.17916.49YesNo499
28B:B:H62 B:B:Y105 57.75913.27NoYes066
29B:B:H62 B:B:R150 57.37815.8NoNo066
30B:B:C148 B:B:R150 33.82244.18NoNo066
31B:B:C148 B:B:T102 27.52773.38NoNo068
32B:B:C149 B:B:T102 27.11725.07YesNo088
33B:B:C149 B:B:T159 11.03133.38YesYes789
34A:A:W234 B:B:Y145 58.81653.86YesYes098
35A:A:K233 B:B:Y145 20.90414.78YesYes198
36B:B:M101 B:B:Y145 50.39158.38YesYes198
37A:A:K233 B:B:D228 19.94528.3YesNo099
38B:B:M61 B:B:W63 11.69425.82NoYes067
39B:B:C317 B:B:M61 11.8294.86NoNo076
40B:B:C317 B:B:S316 11.9773.44NoNo079
41B:B:Q75 B:B:W99 16.10715.48NoYes199
42B:B:R314 B:B:W332 27.361525.99YesYes189
43B:B:W332 B:B:Y59 52.06669.65YesYes198
44A:A:W281 B:B:W332 27.35583.75YesYes159
45A:A:F246 A:A:F273 15.47275.36YesYes099
46A:A:F273 A:A:F345 12.71647.5YesYes598
47A:A:F345 A:A:L270 18.14359.74YesYes086
48A:A:E344 A:A:L270 26.1326.63NoYes056
49A:A:E344 A:A:F312 17.77217.49NoYes058
50A:A:F312 A:A:I308 14.55033.77YesYes087
51A:A:F273 A:A:I348 11.25643.77YesNo094
52A:A:I348 A:A:L270 10.73164.28NoYes046
53B:B:D290 B:B:R314 33.89927.15YesYes168
54A:A:W281 B:B:D290 26.67543.35YesYes156
55R:R:I251 R:R:P252 55.21133.39YesYes944
56R:R:I251 R:R:R266 53.25753.76YesYes947
57R:R:L244 R:R:R266 56.88213.64NoYes087
58R:R:I269 R:R:L244 55.63042.85NoNo078
59A:A:L393 R:R:I269 54.72812.85NoNo087
60A:A:L393 R:R:R145 54.36563.64NoNo089
61R:R:L141 R:R:R145 49.13017.29NoNo099
62R:R:I86 R:R:L141 19.46172.85NoNo089
63R:R:I86 R:R:L330 19.20174.28NoNo089
64R:R:F337 R:R:L330 18.94224.87YesNo099
65R:R:F337 R:R:M78 16.07123.73YesNo097
66R:R:H340 R:R:M78 15.281511.82NoNo057
67R:R:H340 R:R:S336 13.96224.18NoNo056
68R:R:S334 R:R:S336 13.70474.89NoNo086
69A:A:N392 R:R:S334 13.44764.47NoNo078
70A:A:N392 R:R:N83 13.19376.81NoNo078
71B:B:L192 B:B:R150 24.39123.64NoNo056
72B:B:F199 B:B:L192 22.74293.65YesNo095
73B:B:F199 B:B:W211 18.564913.03YesYes698
74B:B:C218 B:B:W211 11.97796.53YesYes658
75B:B:C218 G:G:E22 10.32564.56YesYes659
76B:B:D228 B:B:S227 19.32085.89NoNo096
77B:B:D247 B:B:S227 19.11424.42YesNo096
78B:B:D247 B:B:H225 15.6635.04YesYes1499
79B:B:H225 B:B:T243 13.228612.32YesNo098
80B:B:F253 B:B:T243 12.97986.49YesNo068
81B:B:C271 B:B:D290 60.35446.22YesYes156
82B:B:C271 B:B:Y289 58.20894.03YesYes157
83B:B:W297 B:B:Y289 52.65797.72YesYes187
84B:B:W297 B:B:Y264 45.22035.79YesYes185
85B:B:M262 B:B:Y264 41.358.38NoYes045
86B:B:L30 B:B:M262 40.6677.07YesNo054
87B:B:L30 B:B:T34 40.35465.9YesYes055
88B:B:I37 B:B:T34 20.59764.56YesYes225
89B:B:L300 B:B:T34 18.65445.9NoYes265
90B:B:I37 B:B:R283 18.31136.26YesYes229
91B:B:L300 B:B:R283 18.275412.15NoYes269
92B:B:R283 G:G:L51 32.75683.64YesYes296
93G:G:D48 G:G:L51 30.49654.07YesYes296
94G:G:D48 G:G:L50 24.25974.07YesYes299
95B:B:M45 G:G:L50 20.37485.65NoYes249
96B:B:M45 B:B:W339 17.24343.49NoYes249
97B:B:C149 B:B:I157 15.27543.27YesYes087
98R:R:F85 R:R:L141 32.67013.65YesNo089
99R:R:F85 R:R:I140 31.99237.54YesNo086
100R:R:I140 R:R:V171 31.5343.07NoNo067
101R:R:F136 R:R:V171 31.30763.93NoNo067
102R:R:F136 R:R:F225 30.40645.36NoYes066
103R:R:C221 R:R:F225 27.67084.19NoYes056
104R:R:C221 R:R:H217 27.45417.37NoNo056
105R:R:H217 R:R:Y206 26.810620.69NoYes063
106R:R:Q214 R:R:Y206 23.77044.51YesYes033
107R:R:Q214 R:R:Y291 11.15454.51YesNo036
108R:R:S218 R:R:Y291 10.91615.09NoNo056
109R:R:L292 R:R:S218 21.40556.01NoNo055
110R:R:F222 R:R:L292 20.41664.87YesNo065
111R:R:F222 R:R:Y226 18.91858.25YesYes2768
112R:R:Q214 R:R:S295 12.17814.33YesNo034
113R:R:S218 R:R:S295 10.98636.52NoNo054
114R:R:F72 R:R:N83 12.94624.83YesNo078
115R:R:F72 R:R:F73 11.956912.86YesNo074
116R:R:F73 R:R:F91 11.70953.22NoNo046
117R:R:F91 R:R:I69 11.46345.02NoNo067
118R:R:I69 R:R:L94 11.21891.43NoNo077
119R:R:I62 R:R:L94 10.98021.43NoNo067
120R:R:I62 R:R:L97 10.50967.14NoYes066
121R:R:L230 R:R:Y226 11.9855.86NoYes068
122R:R:F280 R:R:L230 10.98676.09NoNo096
123B:B:V112 B:B:Y105 53.84793.79NoYes2086
124B:B:M101 B:B:Y59 44.5783.59YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9LWP
Class A
SubFamily Peptide
Type Bombesin
SubType BB3
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.93
Date 2025-07-16
D.O.I. doi.org/10.1016/j.apsb.2025.06.025
Net Summary
Imin 3.27
Number of Linked Nodes 834
Number of Links 968
Number of Hubs 136
Number of Links mediated by Hubs 515
Number of Communities 27
Number of Nodes involved in Communities 187
Number of Links involved in Communities 249
Path Summary
Number Of Nodes in MetaPath 125
Number Of Links MetaPath 124
Number of Shortest Paths 912128
Length Of Smallest Path 3
Average Path Length 29.2918
Length of Longest Path 65
Minimum Path Strength 1.155
Average Path Strength 6.44859
Maximum Path Strength 23.9
Minimum Path Correlation 0.71
Average Path Correlation 0.979558
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 48.0426
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.8214
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular process   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • cytoskeletal protein binding   • spectrin binding   • protein-containing complex binding   • protein binding   • binding   • enzyme binding   • GTPase binding   • phosphoric ester hydrolase activity   • alkylglycerophosphoethanolamine phosphodiesterase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • hydrolase activity   • catalytic activity   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity, acting on acid anhydrides   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • response to decreased oxygen levels   • cellular response to stimulus   • response to stimulus   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to chemical stimulus   • cellular response to stress   • response to hypoxia   • response to stress   • response to chemical   • response to oxygen levels   • response to abiotic stimulus   • cellular process   • cell population proliferation   • regulation of biological process   • regulation of cellular process   • signaling   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cell communication   • G protein-coupled receptor signaling pathway   • signal transduction   • muscle cell apoptotic process   • striated muscle cell apoptotic process   • apoptotic process   • cell death   • programmed cell death   • cardiac muscle cell apoptotic process   • photoreceptor inner segment   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • intracellular anatomical structure   • cytoplasm   • membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • plasma membrane region   • organelle membrane   • cell projection membrane   • synapse   • cell junction   • cell body   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • G-protein beta/gamma-subunit complex binding   • signaling receptor binding   • G protein-coupled receptor binding   • cation binding   • metal ion binding   • D1 dopamine receptor binding   • dopamine receptor binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • positive regulation of cell population proliferation   • positive regulation of biological process   • positive regulation of neural precursor cell proliferation   • regulation of cell population proliferation   • neural precursor cell proliferation   • positive regulation of cellular process   • regulation of neural precursor cell proliferation   • reactive oxygen species metabolic process   • regulation of superoxide metabolic process   • positive regulation of reactive oxygen species metabolic process   • superoxide metabolic process   • positive regulation of metabolic process   • superoxide anion generation   • metabolic process   • positive regulation of superoxide anion generation   • regulation of superoxide anion generation   • regulation of metabolic process   • regulation of reactive oxygen species metabolic process   • regulation of calcium ion transport   • regulation of localization   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • intracellular signaling cassette   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • negative regulation of signaling   • negative regulation of biological process   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • negative regulation of cellular process   • regulation of G protein-coupled receptor signaling pathway   • adenylate cyclase-activating adrenergic receptor signaling pathway   • negative regulation of response to stimulus   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • negative regulation of signal transduction   • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell division   • regulation of body fluid levels   • renal system process   • positive regulation of urine volume   • regulation of urine volume   • regulation of vascular associated smooth muscle cell proliferation   • positive regulation of vascular associated smooth muscle cell proliferation   • regulation of smooth muscle cell proliferation   • smooth muscle cell proliferation   • positive regulation of smooth muscle cell proliferation   • muscle cell proliferation   • vascular associated smooth muscle cell proliferation   • cell-cell signaling   • gamma-aminobutyric acid signaling pathway   • purinergic nucleotide receptor signaling pathway   • cell surface receptor signaling pathway   • G protein-coupled purinergic receptor signaling pathway   • G protein-coupled adenosine receptor signaling pathway   • regulation of molecular function   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • regulated exocytosis   • regulation of calcium ion-dependent exocytosis   • negative regulation of transport   • negative regulation of regulated secretory pathway   • vesicle-mediated transport   • regulation of regulated secretory pathway   • secretion by cell   • regulation of secretion by cell   • negative regulation of secretion   • negative regulation of exocytosis   • negative regulation of secretion by cell   • calcium-ion regulated exocytosis   • secretion   • negative regulation of calcium ion-dependent exocytosis   • export from cell   • regulation of vesicle-mediated transport   • regulation of secretion   • exocytosis   • regulation of exocytosis   • regulation of programmed cell death   • negative regulation of apoptotic signaling pathway   • negative regulation of programmed cell death   • regulation of apoptotic process   • apoptotic signaling pathway   • negative regulation of apoptotic process   • regulation of apoptotic signaling pathway   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of cell migration   • regulation of locomotion   • positive regulation of cell motility   • regulation of cell migration   • cell migration   • cell motility   • locomotion   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • trans-synaptic signaling   • modulation of chemical synaptic transmission   • negative regulation of synaptic transmission   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • cellular response to nitrogen compound   • cellular response to acetylcholine   • response to oxygen-containing compound   • response to nitrogen compound   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • cellular response to oxygen-containing compound   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • response to nutrient levels   • response to nutrient   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • response to hormone   • cellular response to hormone stimulus   • skeletal system development   • bone development   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • coagulation   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • regulation of protein transport   • protein secretion   • regulation of protein secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • midbody   • dense core granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle   • secretory granule   • secretory vesicle   • vesicle   • neuronal dense core vesicle   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • membraneless organelle   • intracellular membraneless organelle   • microtubule cytoskeleton   • cytosol   • nucleus   • membrane-enclosed lumen   • intracellular organelle lumen   • nucleoplasm   • organelle lumen   • nuclear lumen   • neuron to neuron synapse   • hippocampal mossy fiber to CA3 synapse   • ciliary basal body   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • neuropeptide receptor activity   • bombesin receptor activity   • oxidoreductase activity   • monooxygenase activity   • Oplophorus-luciferin 2-monooxygenase activity   • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)   • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen   • luciferin monooxygenase activity   • circulatory system process   • regulation of blood pressure   • blood circulation   • behavior   • adult feeding behavior   • adult behavior   • feeding behavior   • monosaccharide metabolic process   • carbohydrate metabolic process   • hexose metabolic process   • small molecule metabolic process   • primary metabolic process   • glucose metabolic process   • bioluminescence
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9LWP_Chain_A
EKAEKIKLD RTRLLLLGA SGKSTIVKG IFETKFQVD KVNFHMFDV 
GRRKWIQCF NDVTAIIFV VSSYNRLQE ALNFKSIWN NRWLRTISV 
ILFLNKQDL LAEKVLAGK SKIEDYFPE FARYTTPDP RVTRAKYFI 
REFISTASG DGRHCYPHF TCVDTENRR FNDCDIIML RYLVSADAA 
RSMDNREGE KARLDNDDD KVDIAIKLQ NENV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>9LWP_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>9LWP_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP32247
Sequence
>9LWP_Chain_R
LCAIYITYA VIISVGILG NAILIKVFF KTKSMQTVP NIFITSLAF 
GDLLLLLTC VPVDATHYG WLFGRIGKV LSFIRLTSV GVSVFTLTI 
LSADRYKAV VKPLERQPS NAILKTCVK AGCVWIVSM IFALPEAIF 
CTSYPVSKK LLQEIHSLL CFLVFYIIP LSIISVYYS LIARTLYKS 
TLNIPTEEQ SHARKQIES RKRIARTVL VLVALFALC WLPNHLLYL 
YHSFTSAMH FIFTIFSRV LAFSNSCVN PFALYWLSK SFQKHFKAQ 
L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8Y52APeptideBombesinBB3Homo sapiensBA1-chim(NtGi1-Gs-CtGq)/β1/γ22.92024-09-11doi.org/10.1016/j.celrep.2024.114511
8Y52 (No Gprot) APeptideBombesinBB3Homo sapiensBA1-2.92024-09-11doi.org/10.1016/j.celrep.2024.114511
8Y53APeptideBombesinBB3Homo sapiensMK5046-chim(NtGi1-Gs-CtGq)/β1/γ22.932024-09-11doi.org/10.1016/j.celrep.2024.114511
8Y53 (No Gprot) APeptideBombesinBB3Homo sapiensMK5046-2.932024-09-11doi.org/10.1016/j.celrep.2024.114511
8Y51APeptideBombesinBB3Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.32025-02-12To be published
8Y51 (No Gprot) APeptideBombesinBB3Homo sapiens--3.32025-02-12To be published
9K07APeptideBombesinBB3Homo sapiensDSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ22.872025-08-27/doi.org/10.1016/j.apsb.2025.06.025
9K07 (No Gprot) APeptideBombesinBB3Homo sapiensDSO-5a-2.872025-08-27/doi.org/10.1016/j.apsb.2025.06.025
9LWP (No Gprot) APeptideBombesinBB3Homo sapiens--2.932025-07-16doi.org/10.1016/j.apsb.2025.06.025




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