psnGPCR

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Orange: nodes, hubs and links specific of s1p5_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p5_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	s1p5_off Int. Strength	s1p5_on Int. Strength	s1p5_off Hub1?	s1p5_on Hub1?	s1p5_off Hub2?	s1p5_on Hub2?	ConSurf1	ConSurf2
1	Lig	NT.Y19	s1p5_off	7.35	0	Yes	Yes	Yes	Yes	0	9
2	2x57	Lig	s1p5_off	10.28	0	Yes	Yes	Yes	Yes	7	0
3	2x61	Lig	s1p5_off	4.47	0	Yes	Yes	Yes	Yes	6	0
4	3x28	Lig	s1p5_off	4.57	0	Yes	Yes	Yes	Yes	5	0
5	E2.P187	Lig	s1p5_off	3.09	0	Yes	No	Yes	Yes	4	0
6	7x35	Lig	s1p5_off	5.95	0	No	No	Yes	Yes	4	0
7	7x39	Lig	s1p5_off	3.22	0	No	No	Yes	Yes	5	0
8	7x42	Lig	s1p5_off	6.2	0	No	No	Yes	Yes	7	0
9	NT.A9	NT.P10	s1p5_off	3.74	0	No	No	No	No	8	5
10	NT.A9	NT.V16	s1p5_off	5.09	0	No	No	No	No	8	2
11	NT.P10	NT.V11	s1p5_off	3.53	0	No	No	No	No	5	4
12	E1x51	NT.V11	s1p5_off	7.59	0	No	No	No	No	2	4
13	NT.I15	NT.S12	s1p5_off	6.19	0	Yes	No	No	No	7	6
14	3x22	NT.V14	s1p5_off	5.3	0	No	No	No	No	2	4
15	NT.I15	NT.Y19	s1p5_off	3.63	0	Yes	No	Yes	Yes	7	9
16	3x25	NT.I15	s1p5_off	3.52	0	Yes	Yes	Yes	No	9	7
17	E2.L188	NT.I15	s1p5_off	4.28	0	Yes	No	Yes	No	4	7
18	NT.L25	NT.V16	s1p5_off	5.96	0	Yes	No	No	No	6	2
19	E1x501	NT.V16	s1p5_off	4.47	0	Yes	No	No	No	6	2
20	E2.L176	NT.H18	s1p5_off	6.43	0	No	No	Yes	Yes	3	8
21	E2.L179	NT.H18	s1p5_off	3.86	0	No	No	Yes	Yes	2	8
22	E2.L188	NT.H18	s1p5_off	7.71	0	Yes	No	Yes	Yes	4	8
23	NT.K24	NT.Y19	s1p5_off	3.58	0	Yes	No	Yes	Yes	6	9
24	E1x50	NT.Y19	s1p5_off	3.75	0	No	No	Yes	Yes	5	9
25	NT.L25	NT.N20	s1p5_off	5.49	0	Yes	No	No	No	6	8
26	E3.R280	NT.Y21	s1p5_off	7.2	0	No	No	Yes	No	3	5
27	E2.T184	NT.T22	s1p5_off	6.28	0	Yes	No	No	No	5	8
28	E2.P187	NT.T22	s1p5_off	3.5	0	Yes	No	No	No	4	8
29	E2.P187	NT.K24	s1p5_off	5.02	0	Yes	No	Yes	No	4	6
30	NT.L25	NT.R29	s1p5_off	6.07	0	Yes	No	No	No	6	2
31	E1x501	NT.A28	s1p5_off	4.73	0	Yes	No	No	No	6	8
32	1x33	NT.Y30	s1p5_off	3.09	0	No	No	No	No	3	3
33	E1x47	NT.Y30	s1p5_off	5.79	0	No	No	No	No	6	3
34	E1x48	NT.Y30	s1p5_off	11.13	0	No	No	No	No	3	3
35	NT.P32	NT.Q31	s1p5_off	3.16	0	No	No	No	No	6	2
36	1x36	NT.L36	s1p5_off	3.15	0	No	No	No	No	4	3
37	1x33	1x35	s1p5_off	11.91	0	No	No	No	No	3	3
38	1x39	2x61	s1p5_off	3.27	0	No	No	Yes	Yes	6	6
39	1x39	7x42	s1p5_off	3.24	0	No	No	No	No	6	7
40	1x45	1x49	s1p5_off	3.5	0	No	No	Yes	No	4	8
41	1x46	2x54	s1p5_off	3.53	0	Yes	Yes	No	No	7	7
42	1x46	7x46	s1p5_off	7.74	0	Yes	Yes	No	No	7	9
43	1x49	1x50	s1p5_off	5.26	0	Yes	No	Yes	Yes	8	9
44	1x49	7x47	s1p5_off	6.63	0	Yes	No	No	No	8	6
45	1x50	2x47	s1p5_off	5.85	0	Yes	Yes	Yes	No	9	9
46	1x51	1x55	s1p5_off	5.54	0	No	No	No	No	4	4
47	1x53	7x53	s1p5_off	3.79	0	Yes	No	Yes	Yes	9	9
48	1x56	1x60	s1p5_off	5.54	0	No	No	Yes	No	7	6
49	1x56	I1x50	s1p5_off	3.93	0	No	No	Yes	No	7	8
50	1x57	I1x50	s1p5_off	3.65	0	No	Yes	Yes	No	7	8
51	1x58	I1x51	s1p5_off	3.18	0	No	No	No	No	3	8
52	1x59	1x60	s1p5_off	7.9	0	No	No	Yes	No	5	6
53	1x60	I1x49	s1p5_off	3.39	0	Yes	No	No	No	6	5
54	1x60	I1x50	s1p5_off	9.05	0	Yes	No	Yes	No	6	8
55	1x60	8x53	s1p5_off	4.39	0	Yes	No	No	No	6	7
56	1x60	8x56	s1p5_off	7.9	0	Yes	No	No	No	6	4
57	I1x49	I1x50	s1p5_off	21.38	0	No	No	Yes	No	5	8
58	8x49	I1x49	s1p5_off	17.87	0	No	No	No	No	6	5
59	2x40	I1x50	s1p5_off	11.79	0	Yes	No	Yes	No	8	8
60	8x50	I1x50	s1p5_off	6.09	0	No	No	Yes	No	8	8
61	2x37	2x39	s1p5_off	3.22	0	No	No	Yes	No	7	8
62	2x39	2x40	s1p5_off	11.2	0	Yes	No	Yes	No	8	8
63	2x39	3x50	s1p5_off	12.41	0	Yes	No	No	No	8	9
64	2x39	6x33	s1p5_off	5.65	0	Yes	No	No	No	8	8
65	2x40	6x33	s1p5_off	3.65	0	Yes	No	No	No	8	8
66	2x41	4x42	s1p5_off	4.42	0	No	No	Yes	Yes	4	6
67	2x42	3x45	s1p5_off	4.73	0	No	No	No	No	8	6
68	2x43	7x53	s1p5_off	10.55	0	No	No	Yes	Yes	8	9
69	2x44	2x47	s1p5_off	3.64	0	No	No	Yes	No	6	9
70	2x45	4x50	s1p5_off	6.18	0	No	No	No	No	9	9
71	2x46	7x53	s1p5_off	3.52	0	Yes	Yes	Yes	Yes	9	9
72	2x47	7x53	s1p5_off	6.24	0	Yes	No	Yes	Yes	9	9
73	2x48	4x50	s1p5_off	7.97	0	No	No	No	No	5	9
74	2x50	7x49	s1p5_off	9.42	0	No	No	Yes	Yes	9	9
75	2x52	3x35	s1p5_off	4.73	0	No	No	No	No	7	7
76	2x53	2x57	s1p5_off	5.34	0	No	No	Yes	Yes	8	7
77	2x53	7x46	s1p5_off	3.42	0	No	No	No	No	8	9
78	2x54	2x57	s1p5_off	4.35	0	No	No	Yes	Yes	7	7
79	2x57	3x32	s1p5_off	3.79	0	Yes	Yes	No	No	7	5
80	2x57	7x42	s1p5_off	7.18	0	Yes	Yes	No	No	7	7
81	2x60	3x29	s1p5_off	10.52	0	No	No	Yes	Yes	5	5
82	2x64	E1x50	s1p5_off	3.2	0	No	No	No	No	5	5
83	2x64	3x28	s1p5_off	9.22	0	No	No	Yes	Yes	5	5
84	3x28	E1x52	s1p5_off	6.07	0	Yes	Yes	No	No	5	5
85	3x21	3x24	s1p5_off	4.5	0	No	No	No	No	7	4
86	3x26	E2.N174	s1p5_off	7.25	0	Yes	Yes	No	No	5	6
87	3x26	E2.Y189	s1p5_off	4.13	0	Yes	Yes	Yes	Yes	5	5
88	3x28	3x29	s1p5_off	12.79	0	Yes	Yes	Yes	Yes	5	5
89	3x33	E2.L186	s1p5_off	3.65	0	No	Yes	No	No	5	7
90	3x36	5x47	s1p5_off	7.31	0	No	No	Yes	No	7	8
91	3x36	6x52	s1p5_off	3.65	0	No	No	Yes	Yes	7	7
92	3x37	4x56	s1p5_off	7.37	0	Yes	No	No	Yes	6	6
93	3x37	5x47	s1p5_off	6.49	0	Yes	No	Yes	No	6	8
94	3x40	5x47	s1p5_off	6.55	0	No	No	Yes	No	8	8
95	3x40	6x44	s1p5_off	3.93	0	No	No	Yes	No	8	9
96	3x43	5x54	s1p5_off	5.71	0	No	Yes	No	No	8	8
97	3x43	6x41	s1p5_off	4.15	0	No	Yes	No	No	8	8
98	3x46	6x37	s1p5_off	5.71	0	No	Yes	No	No	9	8
99	3x47	5x57	s1p5_off	3.15	0	No	No	No	No	8	7
100	3x48	4x45	s1p5_off	7.07	0	No	No	No	No	6	5
101	3x49	3x52	s1p5_off	5.3	0	No	No	No	No	9	4
102	3x49	4x42	s1p5_off	4.23	0	No	No	Yes	Yes	9	6
103	3x51	5x61	s1p5_off	4.64	0	No	No	No	No	8	9
104	4x54	4x58	s1p5_off	8.3	0	No	No	No	No	5	5
105	4x56	5x43	s1p5_off	4.76	0	No	Yes	No	No	6	5
106	4x59	E2.W173	s1p5_off	4.56	0	No	No	Yes	No	5	4
107	5x42	E2.W173	s1p5_off	4.01	0	No	No	Yes	No	5	4
108	E2.L176	E2.N174	s1p5_off	10.98	0	No	No	No	No	3	6
109	E2.L176	E2.L188	s1p5_off	4.15	0	No	No	Yes	No	3	4
110	6x58	E2.S183	s1p5_off	10.31	0	Yes	No	No	No	4	5
111	7x31	E2.T184	s1p5_off	7.37	0	Yes	Yes	Yes	No	1	5
112	6x55	E2.V185	s1p5_off	4.47	0	No	No	No	No	6	4
113	5x39	5x43	s1p5_off	9.41	0	Yes	Yes	No	No	7	5
114	5x40	6x55	s1p5_off	5.96	0	No	No	No	No	6	6
115	5x41	5x45	s1p5_off	8.3	0	No	No	No	No	5	4
116	5x44	6x56	s1p5_off	4.47	0	No	No	No	No	4	5
117	5x51	6x44	s1p5_off	3.65	0	No	No	Yes	No	6	9
118	5x57	5x60	s1p5_off	3.64	0	No	No	No	No	7	6
119	5x58	5x62	s1p5_off	12.91	0	No	Yes	Yes	No	9	6
120	5x58	6x34	s1p5_off	3.52	0	No	Yes	Yes	No	9	7
121	5x58	6x38	s1p5_off	8.9	0	No	Yes	No	No	9	6
122	5x61	6x34	s1p5_off	5.71	0	No	No	Yes	No	9	7
123	5x62	5x65	s1p5_off	3.79	0	Yes	No	No	Yes	6	8
124	5x62	6x30	s1p5_off	7.63	0	Yes	No	No	No	6	7
125	6x30	6x34	s1p5_off	4.5	0	No	No	Yes	No	7	7
126	6x35	7x56	s1p5_off	3.88	0	No	No	Yes	No	7	7
127	6x36	7x56	s1p5_off	7.85	0	No	No	Yes	No	9	7
128	6x39	7x52	s1p5_off	7.68	0	No	No	No	No	7	9
129	6x39	7x56	s1p5_off	3.17	0	No	No	Yes	No	7	7
130	6x40	7x49	s1p5_off	4.43	0	No	No	Yes	Yes	8	9
131	6x48	6x52	s1p5_off	13.03	0	Yes	No	Yes	Yes	9	7
132	6x48	7x41	s1p5_off	7.78	0	Yes	No	No	No	9	7
133	6x57	6x61	s1p5_off	4.76	0	No	No	Yes	No	5	5
134	6x57	7x31	s1p5_off	4.15	0	No	No	Yes	Yes	5	1
135	6x61	E3.T281	s1p5_off	3.38	0	Yes	No	No	No	5	4
136	E3.C282	E3.T281	s1p5_off	5.07	0	Yes	Yes	No	No	4	4
137	7x36	7x37	s1p5_off	8.67	0	No	No	No	No	4	5
138	7x49	7x53	s1p5_off	5.81	0	Yes	Yes	Yes	Yes	9	9
139	8x47	8x50	s1p5_off	15.1	0	No	No	No	No	8	8
140	8x48	8x51	s1p5_off	10.66	0	No	No	No	No	5	9
141	8x48	8x52	s1p5_off	12.41	0	No	No	No	No	5	4
142	8x56	8x57	s1p5_off	7.29	0	No	No	No	No	4	5
143	2x46	2x49	s1p5_off	3	0	Yes	Yes	No	No	9	8
144	2x46	3x39	s1p5_off	3	0	Yes	Yes	No	No	9	9
145	1x53	8x54	s1p5_off	2.98	0	Yes	No	Yes	No	9	6
146	1x56	8x54	s1p5_off	2.98	0	No	No	Yes	No	7	6
147	2x52	3x34	s1p5_off	2.98	0	No	No	Yes	No	7	5
148	3x41	4x52	s1p5_off	2.98	0	No	No	No	No	5	4
149	5x41	6x59	s1p5_off	2.98	0	No	No	No	No	5	4
150	5x44	6x55	s1p5_off	2.98	0	No	No	No	No	4	6
151	7x30	7x33	s1p5_off	2.87	0	No	No	No	Yes	4	4
152	7x51	7x55	s1p5_off	2.85	0	No	No	No	No	6	5
153	E1x49	E1x51	s1p5_off	2.82	0	No	No	No	No	4	2
154	1x33	1x36	s1p5_off	2.77	0	No	No	No	No	3	4
155	6x31	6x34	s1p5_off	2.77	0	No	No	Yes	No	4	7
156	6x51	7x38	s1p5_off	2.77	0	No	No	No	No	7	5
157	6x54	7x31	s1p5_off	2.77	0	No	No	Yes	Yes	5	1
158	7x54	8x51	s1p5_off	2.59	0	No	No	No	No	7	9
159	3x50	6x31	s1p5_off	2.43	0	No	No	No	No	9	4
160	NT.A34	NT.G35	s1p5_off	1.95	0	No	No	No	No	3	3
161	2x56	3x31	s1p5_off	1.95	0	No	No	No	No	5	5
162	2x64	E1x47	s1p5_off	1.86	0	No	No	No	No	5	6
163	3x34	4x57	s1p5_off	1.84	0	Yes	No	No	No	5	8
164	5x36	E2.C175	s1p5_off	1.81	0	No	No	No	No	5	6
165	2x45	4x46	s1p5_off	1.71	0	No	No	No	No	9	7
166	1x47	2x55	s1p5_off	1.7	0	No	No	No	No	6	3
167	7x34	E2.V185	s1p5_off	1.7	0	No	No	No	No	4	4
168	1x43	2x61	s1p5_off	1.64	0	No	No	Yes	Yes	6	6
169	3x47	5x54	s1p5_off	1.62	0	No	No	No	No	8	8
170	6x43	7x52	s1p5_off	1.62	0	No	No	No	No	7	9
171	2x39	6x32	s1p5_off	1.61	0	Yes	No	No	No	8	8
172	5x44	5x48	s1p5_off	1.6	0	No	No	No	No	4	4
173	6x47	7x48	s1p5_off	1.59	0	No	No	No	No	8	6
174	1x52	8x54	s1p5_off	1.58	0	No	No	Yes	No	6	6
175	1x52	8x57	s1p5_off	1.58	0	No	No	No	No	6	5
176	1x60	I1x48	s1p5_off	1.53	0	Yes	No	No	No	6	5
177	6x49	6x52	s1p5_off	1.51	0	No	No	Yes	Yes	5	7
178	1x37	NT.L36	s1p5_off	1.49	0	No	No	No	No	5	3
179	6x54	7x30	s1p5_off	1.49	0	No	No	No	No	5	4
180	8x57	8x58	s1p5_off	1.49	0	No	No	No	No	5	6
181	3x52	3x53	s1p5_off	1.47	0	No	No	No	No	4	8
182	7x32	E2.T184	s1p5_off	1.47	0	No	No	Yes	No	1	5
183	7x54	7x55	s1p5_off	1.47	0	No	No	No	No	7	5
184	7x54	8x54	s1p5_off	1.47	0	No	No	Yes	No	7	6
185	7x55	7x56	s1p5_off	1.47	0	No	No	Yes	No	5	7
186	NT.P8	NT.R7	s1p5_off	1.44	0	No	No	No	No	6	6
187	5x63	5x66	s1p5_off	1.39	0	No	No	No	No	4	5
188	1x40	2x62	s1p5_off	1.38	0	No	No	No	No	4	5
189	4x55	4x59	s1p5_off	1.38	0	No	No	No	No	3	5
190	NT.E13	NT.L6	s1p5_off	1.33	0	No	No	No	No	4	6
191	4x38	4x39	s1p5_off	1.32	0	No	No	No	No	6	7
192	4x38	4x41	s1p5_off	1.32	0	No	No	No	No	6	7
193	8x51	8x55	s1p5_off	1.21	0	No	No	No	No	9	4
194	Lig	NT.K24	Shared	3.53	4.67	Yes	Yes	Yes	No	0	6
195	2x60	Lig	Shared	8.6	11.82	No	No	Yes	Yes	5	0
196	3x29	Lig	Shared	14.12	9.65	Yes	Yes	Yes	Yes	5	0
197	3x32	Lig	Shared	7.47	0.99	No	No	Yes	Yes	5	0
198	7x38	Lig	Shared	19.95	7.33	No	No	Yes	Yes	5	0
199	E2.C182	NT.H18	Shared	4.42	14.74	No	No	Yes	Yes	9	8
200	E1x501	NT.Y19	Shared	5.86	3.52	Yes	No	Yes	Yes	6	9
201	3x25	NT.Y19	Shared	5.79	3.86	Yes	Yes	Yes	Yes	9	9
202	E2.P187	NT.Y19	Shared	12.52	25.03	Yes	No	Yes	Yes	4	9
203	E2.L179	NT.Y21	Shared	16.41	3.52	No	No	Yes	No	2	5
204	E2.D180	NT.Y21	Shared	9.2	11.49	No	No	Yes	No	3	5
205	NT.K24	NT.T22	Shared	6.01	3	Yes	No	No	No	6	8
206	E1x501	NT.L25	Shared	4.15	8.3	Yes	No	Yes	No	6	6
207	1x40	2x61	Shared	7.14	4.28	No	No	Yes	Yes	4	6
208	1x42	1x46	Shared	3.07	3.07	No	No	Yes	Yes	6	7
209	1x43	2x58	Shared	3.61	3.61	No	No	No	No	6	7
210	1x46	7x47	Shared	4.28	8.56	Yes	Yes	No	No	7	6
211	1x49	7x50	Shared	17.29	3.14	Yes	No	No	Yes	8	9
212	1x50	2x50	Shared	6.73	10.77	Yes	Yes	No	No	9	9
213	1x50	2x51	Shared	4.12	5.49	Yes	Yes	No	No	9	7
214	1x50	7x50	Shared	9.77	3.26	Yes	Yes	No	Yes	9	9
215	1x53	2x47	Shared	4.76	1.59	Yes	No	Yes	No	9	9
216	1x53	7x50	Shared	3.53	5.3	Yes	No	No	Yes	9	9
217	1x54	2x47	Shared	5.9	2.95	No	No	Yes	No	7	9
218	1x57	2x40	Shared	3.65	9.74	No	Yes	Yes	No	7	8
219	2x38	3x49	Shared	3.14	3.14	No	Yes	No	No	5	9
220	2x38	4x42	Shared	6.99	5.25	No	Yes	Yes	Yes	5	6
221	2x42	3x46	Shared	4.28	5.71	No	No	No	Yes	8	9
222	2x42	4x42	Shared	4.42	2.95	No	No	Yes	Yes	8	6
223	2x45	3x42	Shared	4.89	1.63	No	No	No	No	9	8
224	2x46	7x49	Shared	4.12	2.75	Yes	Yes	Yes	Yes	9	9
225	2x49	3x39	Shared	6.52	1.63	No	No	No	No	8	9
226	2x50	7x46	Shared	4.42	8.83	No	No	No	No	9	9
227	2x60	3x28	Shared	9.64	3.62	No	No	Yes	Yes	5	5
228	2x63	3x28	Shared	3.64	14.58	No	No	Yes	Yes	4	5
229	E1x47	E1x48	Shared	4.06	4.06	No	No	No	No	6	3
230	3x28	E1x50	Shared	11.64	6.47	Yes	Yes	No	No	5	5
231	3x24	E1x52	Shared	4.15	5.54	No	No	No	No	4	5
232	3x21	3x22	Shared	3.56	3.56	No	No	No	No	7	2
233	3x25	3x26	Shared	10.02	3.01	Yes	Yes	Yes	Yes	9	5
234	3x25	3x28	Shared	8	8	Yes	Yes	Yes	Yes	9	5
235	3x25	3x29	Shared	6.54	3.27	Yes	Yes	Yes	Yes	9	5
236	3x25	E2.L188	Shared	20.5	6.83	Yes	Yes	Yes	No	9	4
237	3x25	E2.Y189	Shared	4.82	5.79	Yes	Yes	Yes	Yes	9	5
238	3x26	E2.L188	Shared	6.09	8.53	Yes	Yes	Yes	No	5	4
239	3x29	E2.L186	Shared	5.3	5.3	Yes	Yes	No	No	5	7
240	3x29	E2.Y189	Shared	3.37	12.35	Yes	Yes	Yes	Yes	5	5
241	3x33	E2.Y189	Shared	9.28	4.13	No	Yes	Yes	Yes	5	5
242	3x36	6x48	Shared	15.94	6.83	No	No	Yes	No	7	9
243	3x37	4x53	Shared	6.4	3.2	Yes	No	No	No	6	7
244	3x38	4x50	Shared	7.78	3.89	No	No	No	No	7	9
245	3x38	4x53	Shared	3.42	3.42	No	No	No	No	7	7
246	3x40	5x50	Shared	4.61	3.07	No	No	No	No	8	8
247	3x41	4x49	Shared	3.15	3.15	No	No	No	No	5	7
248	3x44	5x50	Shared	4.28	7.14	No	No	No	No	7	8
249	3x44	5x54	Shared	4.28	5.71	No	No	No	No	7	8
250	3x45	4x45	Shared	3.22	1.61	No	No	No	No	6	5
251	4x56	5x39	Shared	4.69	1.17	No	Yes	Yes	Yes	6	7
252	4x60	E2.Y189	Shared	12.52	5.56	No	No	Yes	Yes	6	5
253	4x60	5x39	Shared	13.91	12.52	No	No	Yes	Yes	6	7
254	5x39	E2.W173	Shared	14.47	6.75	Yes	Yes	Yes	No	7	4
255	E2.C175	E2.C182	Shared	7.28	5.46	No	No	No	No	6	9
256	E2.A181	E2.R178	Shared	5.53	1.38	No	No	No	No	4	3
257	5x40	E2.S183	Shared	3.23	1.62	No	No	No	No	6	5
258	6x58	E2.T184	Shared	8.67	5.78	Yes	No	Yes	No	4	5
259	6x58	E2.V185	Shared	4.38	2.92	Yes	No	No	No	4	4
260	E2.L186	E2.Y189	Shared	11.72	8.21	No	No	Yes	Yes	7	5
261	5x39	E2.Y189	Shared	3.97	5.96	Yes	Yes	Yes	Yes	7	5
262	5x40	6x59	Shared	3.21	1.6	No	No	No	No	6	4
263	5x47	6x52	Shared	7.5	9.65	Yes	No	Yes	Yes	8	7
264	5x62	5x66	Shared	4.12	12.35	Yes	No	No	No	6	5
265	5x62	6x34	Shared	17.58	14.07	Yes	No	Yes	No	6	7
266	6x40	7x52	Shared	4.61	3.07	No	No	No	No	8	9
267	6x44	6x48	Shared	13.03	7.02	Yes	No	Yes	No	9	9
268	6x44	7x45	Shared	6.04	12.08	Yes	No	No	Yes	9	9
269	6x47	7x45	Shared	9.45	6.3	No	No	No	Yes	8	9
270	6x48	7x45	Shared	6.78	18.08	Yes	No	No	Yes	9	9
271	6x49	6x50	Shared	4.06	4.06	No	No	No	No	5	9
272	6x54	7x37	Shared	6.09	14.61	No	No	No	No	5	5
273	6x58	7x31	Shared	6.79	4.07	Yes	No	Yes	Yes	4	1
274	6x61	E3.C282	Shared	7.28	7.28	Yes	No	Yes	Yes	5	4
275	6x61	7x31	Shared	3.17	4.76	Yes	No	Yes	Yes	5	1
276	E3.P278	E3.T281	Shared	12.24	1.75	No	No	No	No	3	4
277	7x31	E3.C282	Shared	3.17	4.76	Yes	Yes	Yes	Yes	1	4
278	5x51	6x45	Shared	2.98	1.49	No	No	No	No	6	6
279	3x37	3x41	Shared	2.95	1.47	Yes	No	No	No	6	5
280	2x46	3x46	Shared	2.85	2.85	Yes	Yes	No	Yes	9	9
281	3x26	4x61	Shared	2.77	2.77	Yes	Yes	No	No	5	5
282	E3.A279	NT.Y21	Shared	2.67	6.67	No	No	Yes	No	2	5
283	5x38	E2.W173	Shared	2.59	3.89	No	No	Yes	No	4	4
284	3x30	3x31	Shared	2.11	2.11	No	No	No	No	6	5
285	7x29	E3.C282	Shared	1.88	1.88	No	No	Yes	Yes	4	4
286	1x47	2x54	Shared	1.84	1.84	No	No	No	No	6	7
287	3x31	3x34	Shared	1.84	1.84	No	No	Yes	No	5	5
288	E2.A181	E2.C175	Shared	1.81	3.61	No	No	No	No	4	6
289	2x53	3x35	Shared	1.79	1.79	No	No	No	No	8	7
290	3x21	3x23	Shared	1.71	1.71	No	No	No	No	7	1
291	4x63	E2.N174	Shared	1.7	1.7	No	No	No	No	5	6
292	6x50	7x40	Shared	1.64	1.64	No	No	No	No	9	7
293	5x37	E2.S183	Shared	1.53	9.18	No	No	No	No	4	5
294	4x39	4x40	Shared	1.5	1.5	No	No	No	No	7	3
295	3x34	4x54	Shared	1.49	2.98	Yes	No	No	No	5	5
296	6x57	7x30	Shared	1.49	1.49	No	No	No	No	5	4
297	E2.L179	NT.L17	Shared	1.38	13.84	No	No	No	No	2	3
298	1x51	2x51	Shared	1.38	1.38	No	No	No	No	4	7
299	6x53	6x56	Shared	1.38	2.77	No	No	No	No	5	5
300	E2.L176	NT.V14	s1p5_on	0	10.43	No	No	No	No	3	4
301	3x22	NT.I15	s1p5_on	0	11.85	No	No	Yes	No	2	7
302	NT.H18	NT.L17	s1p5_on	0	11.57	Yes	Yes	No	No	8	3
303	E2.C175	NT.H18	s1p5_on	0	4.42	No	No	Yes	Yes	6	8
304	E2.P187	NT.H18	s1p5_on	0	3.05	Yes	No	Yes	Yes	4	8
305	NT.L25	NT.Y19	s1p5_on	0	3.52	Yes	No	Yes	Yes	6	9
306	NT.G23	NT.T22	s1p5_on	0	3.64	No	No	No	No	7	8
307	NT.G23	NT.R26	s1p5_on	0	7.51	No	No	No	No	7	3
308	1x33	1x34	s1p5_on	0	2.77	No	No	No	No	3	7
309	1x33	1x37	s1p5_on	0	3.92	No	No	No	No	3	5
310	1x35	7x33	s1p5_on	0	6.53	No	No	No	Yes	3	4
311	1x35	7x35	s1p5_on	0	3.99	No	No	No	No	3	4
312	1x39	2x57	s1p5_on	0	8.06	No	No	Yes	Yes	6	7
313	1x46	1x50	s1p5_on	0	4.25	Yes	Yes	Yes	Yes	7	9
314	1x47	2x51	s1p5_on	0	2.98	No	No	No	No	6	7
315	1x49	1x53	s1p5_on	0	7.13	Yes	No	Yes	No	8	9
316	1x54	2x48	s1p5_on	0	2.77	No	No	No	No	7	5
317	1x57	1x58	s1p5_on	0	3.42	No	Yes	No	No	7	3
318	1x57	2x44	s1p5_on	0	3.42	No	Yes	No	No	7	6
319	2x38	4x38	s1p5_on	0	10.69	No	Yes	No	No	5	6
320	2x39	7x56	s1p5_on	0	7.53	Yes	No	Yes	No	8	7
321	2x43	2x47	s1p5_on	0	2.95	No	No	Yes	No	8	9
322	2x46	3x42	s1p5_on	0	7.51	Yes	Yes	No	No	9	8
323	2x46	3x43	s1p5_on	0	2.77	Yes	Yes	No	Yes	9	8
324	2x49	3x38	s1p5_on	0	3.42	No	No	No	No	8	7
325	2x49	4x50	s1p5_on	0	3.71	No	No	No	No	8	9
326	2x50	7x50	s1p5_on	0	3.22	No	No	No	Yes	9	9
327	2x56	3x32	s1p5_on	0	3.39	No	No	No	No	5	5
328	2x57	2x61	s1p5_on	0	10.88	Yes	Yes	Yes	Yes	7	6
329	2x57	7x38	s1p5_on	0	15.24	Yes	Yes	No	No	7	5
330	2x63	E1x50	s1p5_on	0	2.95	No	No	No	No	4	5
331	E1x50	E1x52	s1p5_on	0	5.9	No	No	No	No	5	5
332	3x25	E2.L186	s1p5_on	0	4.56	Yes	Yes	No	No	9	7
333	3x26	4x60	s1p5_on	0	4.33	Yes	Yes	No	No	5	6
334	3x33	5x39	s1p5_on	0	9.28	No	Yes	Yes	Yes	5	7
335	3x33	Lig	s1p5_on	0	7.26	No	Yes	Yes	Yes	5	0
336	3x34	4x53	s1p5_on	0	3.23	Yes	No	No	No	5	7
337	3x36	Lig	s1p5_on	0	7.33	No	No	Yes	Yes	7	0
338	3x37	Lig	s1p5_on	0	10.74	Yes	No	Yes	Yes	6	0
339	3x40	Lig	s1p5_on	0	7.89	No	No	Yes	Yes	8	0
340	3x43	7x45	s1p5_on	0	2.75	No	Yes	No	Yes	8	9
341	3x43	7x49	s1p5_on	0	2.75	No	Yes	Yes	Yes	8	9
342	3x43	7x53	s1p5_on	0	3.52	No	Yes	Yes	Yes	8	9
343	3x46	3x50	s1p5_on	0	3.76	No	Yes	No	No	9	9
344	3x46	7x53	s1p5_on	0	3.63	No	Yes	Yes	Yes	9	9
345	3x47	5x58	s1p5_on	0	5.34	No	No	No	Yes	8	9
346	3x49	4x38	s1p5_on	0	4.31	No	No	No	No	9	6
347	3x50	5x58	s1p5_on	0	5.14	No	No	No	Yes	9	9
348	3x50	7x53	s1p5_on	0	6.17	No	No	Yes	Yes	9	9
349	3x51	5x60	s1p5_on	0	6.59	No	No	No	No	8	6
350	3x53	3x56	s1p5_on	0	7.76	No	No	No	No	8	0
351	3x54	5x61	s1p5_on	0	5.83	No	No	No	No	0	9
352	3x56	I2x54	s1p5_on	0	17.29	No	No	No	No	0	0
353	I2x51	I2x52	s1p5_on	0	4.06	No	No	No	No	0	0
354	4x42	4x43	s1p5_on	0	2.95	Yes	Yes	No	No	6	1
355	4x42	4x45	s1p5_on	0	3.01	Yes	Yes	No	No	6	5
356	4x59	5x39	s1p5_on	0	7.03	No	No	Yes	Yes	5	7
357	E2.L188	E2.N174	s1p5_on	0	5.49	Yes	No	No	No	4	6
358	E2.T184	E2.V185	s1p5_on	0	3.17	Yes	No	No	No	5	4
359	7x31	E2.V185	s1p5_on	0	2.98	Yes	Yes	No	No	1	4
360	5x43	Lig	s1p5_on	0	11.56	No	No	Yes	Yes	5	0
361	5x44	6x52	s1p5_on	0	3.93	No	No	Yes	Yes	4	7
362	5x47	Lig	s1p5_on	0	4.84	Yes	No	Yes	Yes	8	0
363	5x48	6x52	s1p5_on	0	3.93	No	No	Yes	Yes	4	7
364	5x58	6x37	s1p5_on	0	8.21	No	Yes	No	No	9	8
365	5x58	6x41	s1p5_on	0	4.69	No	Yes	No	No	9	8
366	5x62	6x33	s1p5_on	0	4.69	Yes	No	No	No	6	8
367	5x64	5x68	s1p5_on	0	3.96	No	No	No	No	5	7
368	6x27	6x28	s1p5_on	0	3.35	No	No	No	No	0	0
369	6x33	6x37	s1p5_on	0	2.77	No	No	No	No	8	8
370	6x34	6x38	s1p5_on	0	3	Yes	No	No	No	7	6
371	6x47	7x43	s1p5_on	0	3.61	No	No	No	No	8	5
372	6x50	7x37	s1p5_on	0	2.89	No	No	No	No	9	5
373	6x51	6x55	s1p5_on	0	5.54	No	No	No	No	7	6
374	6x51	Lig	s1p5_on	0	6.42	No	No	Yes	Yes	7	0
375	6x52	6x56	s1p5_on	0	6.09	Yes	Yes	No	No	7	5
376	6x54	6x55	s1p5_on	0	2.77	No	No	No	No	5	6
377	6x54	6x57	s1p5_on	0	4.15	No	No	No	No	5	5
378	6x57	E3.C282	s1p5_on	0	3.17	No	No	Yes	Yes	5	4
379	7x33	7x35	s1p5_on	0	5.22	No	Yes	No	No	4	4
380	7x33	7x36	s1p5_on	0	7.9	No	Yes	No	No	4	4
381	7x38	7x42	s1p5_on	0	2.83	No	No	No	No	5	7
382	7x42	7x46	s1p5_on	0	7.67	No	No	No	No	7	9
383	7x43	7x47	s1p5_on	0	3.15	No	No	No	No	5	6
384	7x45	7x49	s1p5_on	0	5.45	No	Yes	Yes	Yes	9	9
385	7x47	7x48	s1p5_on	0	2.77	No	No	No	No	6	6
386	7x48	7x51	s1p5_on	0	2.85	No	No	No	No	6	6
387	7x49	7x50	s1p5_on	0	3.26	Yes	Yes	No	Yes	9	9
388	7x52	7x53	s1p5_on	0	4.84	No	No	Yes	Yes	9	9
389	7x32	7x33	s1p5_on	0	2.66	No	No	No	Yes	1	4
390	4x41	I2x56	s1p5_on	0	2.64	No	No	No	No	7	0
391	5x36	E2.W173	s1p5_on	0	2.59	No	No	Yes	No	5	4
392	1x45	1x46	s1p5_on	0	2.51	No	No	Yes	Yes	4	7
393	3x52	4x41	s1p5_on	0	2.43	No	No	No	No	4	7
394	4x39	4x43	s1p5_on	0	2.43	No	No	No	No	7	1
395	7x31	E3.R280	s1p5_on	0	2.43	Yes	Yes	No	No	1	3
396	7x32	E3.R280	s1p5_on	0	2.43	No	No	No	No	1	3
397	2x52	4x50	s1p5_on	0	2.28	No	No	No	No	7	9
398	7x34	Lig	s1p5_on	0	2.09	No	No	Yes	Yes	4	0
399	I2x51	I2x54	s1p5_on	0	2.03	No	No	No	No	0	0
400	1x39	7x39	s1p5_on	0	1.96	No	No	No	No	6	5
401	2x53	2x54	s1p5_on	0	1.95	No	No	No	No	8	7
402	5x49	5x52	s1p5_on	0	1.95	No	No	No	No	4	3
403	6x61	E3.P278	s1p5_on	0	1.88	Yes	No	No	No	5	3
404	2x37	2x38	s1p5_on	0	1.87	No	No	No	Yes	7	5
405	I2x53	I2x54	s1p5_on	0	1.87	No	No	No	No	0	0
406	5x48	5x49	s1p5_on	0	1.84	No	No	No	No	4	4
407	E1x47	E1x501	s1p5_on	0	1.71	No	No	Yes	No	6	6
408	4x51	4x54	s1p5_on	0	1.71	No	No	No	No	4	5
409	5x37	E3.P278	s1p5_on	0	1.67	No	No	No	No	4	3
410	E1x48	E1x49	s1p5_on	0	1.64	No	No	No	No	3	4
411	1x36	2x61	s1p5_on	0	1.62	No	No	Yes	Yes	4	6
412	5x65	6x30	s1p5_on	0	1.62	No	Yes	No	No	8	7
413	3x44	5x53	s1p5_on	0	1.58	No	No	No	No	7	5
414	6x43	7x48	s1p5_on	0	1.58	No	No	No	No	7	6
415	6x51	7x41	s1p5_on	0	1.58	No	No	No	No	7	7
416	2x61	2x64	s1p5_on	0	1.55	Yes	Yes	No	No	6	5
417	3x54	5x65	s1p5_on	0	1.52	No	No	No	Yes	0	8
418	3x33	4x57	s1p5_on	0	1.51	No	Yes	No	No	5	8
419	1x58	1x59	s1p5_on	0	1.5	No	No	No	No	3	5
420	3x51	5x57	s1p5_on	0	1.5	No	No	No	No	8	7
421	NT.L17	NT.V14	s1p5_on	0	1.49	No	No	No	No	3	4
422	1x47	1x48	s1p5_on	0	1.49	No	No	No	No	6	4
423	4x52	4x56	s1p5_on	0	1.49	No	No	No	Yes	4	6
424	5x65	6x33	s1p5_on	0	1.49	No	Yes	No	No	8	8
425	7x56	8x47	s1p5_on	0	1.46	Yes	No	No	No	7	8
426	6x26	6x28	s1p5_on	0	1.44	No	No	No	No	0	0
427	5x64	5x65	s1p5_on	0	1.43	No	No	No	Yes	5	8
428	1x57	2x43	s1p5_on	0	1.38	No	Yes	No	No	7	8
429	3x48	5x57	s1p5_on	0	1.38	No	No	No	No	6	7
430	3x55	5x60	s1p5_on	0	1.38	No	No	No	No	0	6
431	4x55	4x56	s1p5_on	0	1.38	No	No	No	Yes	3	6
432	4x59	4x62	s1p5_on	0	1.38	No	No	No	No	5	5
433	5x68	5x72	s1p5_on	0	1.37	No	No	No	No	7	0
434	1x43	2x57	s1p5_on	0	1.34	No	No	Yes	Yes	6	7
435	3x56	I2x55	s1p5_on	0	1.31	No	No	No	No	0	0
436	6x44	6x45	s1p5_on	0	1.31	Yes	No	No	No	9	6
437	6x35	6x36	s1p5_on	0	1.29	No	No	No	No	7	9
438	4x41	4x45	s1p5_on	0	1.24	No	No	No	No	7	5
439	4x56	5x42	s1p5_on	0	1.22	No	Yes	No	No	6	5
440	2x40	I1x51	s1p5_on	0	1.13	Yes	No	No	No	8	8
441	4x39	I1x51	s1p5_on	0	1.13	No	No	No	No	7	8

Orange: nodes, hubs and links specific of s1p5_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p5_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	s1p5_off Avg Int. Strength	s1p5_on Avg Int. Strength	s1p5_off Num Of Links	s1p5_on Num Of Links	ConSurf
1	NT.I15	s1p5_off	4.405	11.85	4	1	7
2	NT.Y21	s1p5_off	8.87	7.22667	4	3	5
3	NT.K24	s1p5_off	4.535	3.835	4	2	6
4	NT.L25	s1p5_off	5.4175	5.91	4	2	6
5	1x49	s1p5_off	8.17	5.135	4	2	8
6	1x53	s1p5_off	3.765	4.67333	4	3	9
7	1x60	s1p5_off	5.67143	0	7	0	6
8	I1x50	s1p5_off	9.315	0	6	0	8
9	2x39	s1p5_off	6.818	7.53	5	1	8
10	2x40	s1p5_off	7.5725	5.435	4	2	8
11	2x47	s1p5_off	5.278	2.49667	5	3	9
12	E1x501	s1p5_off	4.8025	4.51	4	3	6
13	3x34	s1p5_off	2.0375	2.68333	4	3	5
14	3x37	s1p5_off	5.8025	5.13667	4	3	6
15	E2.W173	s1p5_off	6.4075	4.41	4	3	4
16	E2.T184	s1p5_off	5.9475	4.475	4	2	5
17	E2.P187	s1p5_off	6.0325	14.04	4	2	4
18	E2.L188	s1p5_off	8.546	6.95	5	3	4
19	5x47	s1p5_off	6.9625	7.245	4	2	8
20	5x62	s1p5_off	9.206	10.37	5	3	6
21	6x34	s1p5_off	6.816	8.535	5	2	7
22	6x44	s1p5_off	6.6625	6.80333	4	3	9
23	6x48	s1p5_off	11.312	10.6433	5	3	9
24	6x58	s1p5_off	7.5375	4.25667	4	3	4
25	6x61	s1p5_off	4.6475	4.64	4	3	5
26	7x56	s1p5_off	4.0925	4.495	4	2	7
27	8x54	s1p5_off	2.2525	0	4	0	6
28	Lig	Shared	7.6	7.12231	13	13	0
29	NT.H18	Shared	5.605	8.445	4	4	8
30	NT.Y19	Shared	6.06857	8.9825	7	4	9
31	1x46	Shared	4.655	4.5975	4	4	7
32	1x50	Shared	6.346	5.9425	5	4	9
33	2x46	Shared	3.298	3.97	5	4	9
34	2x57	Shared	6.188	8.88	5	4	7
35	2x61	Shared	4.13	4.5825	4	4	6
36	3x25	Shared	8.45571	5.04571	7	7	9
37	3x26	Shared	6.052	4.66	5	4	5
38	3x28	Shared	8.19625	8.1675	8	4	5
39	3x29	Shared	8.77333	7.6425	6	4	5
40	4x42	Shared	5.015	3.54	4	4	6
41	E2.Y189	Shared	7.11572	7	7	6	5
42	5x39	Shared	9.29	7.11833	5	6	7
43	6x52	Shared	6.4225	5.9	4	4	7
44	E3.C282	Shared	4.35	4.2725	4	4	4
45	7x31	Shared	4.57	3.8	6	5	1
46	7x49	Shared	5.945	3.5525	4	4	9
47	7x53	Shared	5.982	4.54	5	4	9
48	1x57	s1p5_on	3.65	4.49	2	4	7
49	2x38	s1p5_on	5.065	5.2375	2	4	5
50	3x33	s1p5_on	6.465	5.545	2	4	5
51	3x43	s1p5_on	4.93	2.9475	2	4	8
52	3x46	s1p5_on	4.28	3.9875	3	4	9
53	4x56	s1p5_on	5.60667	1.315	3	4	6
54	5x58	s1p5_on	8.44333	5.845	3	4	9
55	5x65	s1p5_on	3.79	1.515	1	4	8
56	7x33	s1p5_on	2.87	5.5775	1	4	4
57	7x45	s1p5_on	7.42333	8.932	3	5	9
58	7x50	s1p5_on	10.1967	3.636	3	5	9

Orange: nodes, hubs and links specific of s1p5_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p5_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	s1p5_off Recurrence	s1p5_on Recurrence	s1p5_off Hub1?	s1p5_on Hub1?	s1p5_off Hub2?	s1p5_on Hub2?	ConSurf1	ConSurf2
1	Lig	NT.Y19	s1p5_off	20.943	0	Yes	Yes	Yes	Yes	0	9
2	3x28	Lig	s1p5_off	18.1781	0	Yes	Yes	Yes	Yes	5	0
3	3x25	3x28	s1p5_off	10.8236	1.92261	Yes	Yes	Yes	Yes	9	5
4	3x25	E2.L188	s1p5_off	22.2995	5.75168	Yes	Yes	Yes	No	9	4
5	E2.L188	NT.H18	s1p5_off	27.579	0	Yes	No	Yes	Yes	4	8
6	E2.L179	NT.H18	s1p5_off	13.8851	0	No	No	Yes	Yes	2	8
7	E2.C182	NT.H18	s1p5_off	11.5778	1.99531	No	No	Yes	Yes	9	8
8	Lig	NT.K24	s1p5_off	19.4363	7.98934	Yes	Yes	Yes	No	0	6
9	NT.K24	NT.T22	s1p5_off	25.4772	6.0748	Yes	No	No	No	6	8
10	E2.P187	Lig	s1p5_off	19.4363	0	Yes	No	Yes	Yes	4	0
11	E2.P187	NT.T22	s1p5_off	25.4772	0	Yes	No	No	No	4	8
12	E2.T184	NT.T22	s1p5_off	49.4692	0	Yes	No	No	No	5	8
13	1x46	2x54	s1p5_off	22.3227	0	Yes	Yes	No	No	7	7
14	2x54	2x57	s1p5_off	23.2128	0	No	No	Yes	Yes	7	7
15	2x57	Lig	s1p5_off	100	0	Yes	Yes	Yes	Yes	7	0
16	1x49	7x47	s1p5_off	21.2325	0	Yes	No	No	No	8	6
17	1x46	7x47	s1p5_off	21.5399	2.31844	Yes	Yes	No	No	7	6
18	2x53	7x46	s1p5_off	76.7944	0	No	No	No	No	8	9
19	2x53	2x57	s1p5_off	78.117	0	No	No	Yes	Yes	8	7
20	1x49	7x50	s1p5_off	20.3782	2.61734	Yes	No	No	Yes	8	9
21	1x50	7x50	s1p5_off	20.9501	8.19129	Yes	Yes	No	Yes	9	9
22	1x50	2x47	s1p5_off	22.1225	0	Yes	Yes	Yes	No	9	9
23	1x53	7x53	s1p5_off	21.8151	0	Yes	No	Yes	Yes	9	9
24	7x49	7x53	s1p5_off	21.2861	0	Yes	Yes	Yes	Yes	9	9
25	2x50	7x49	s1p5_off	32.9622	0	No	No	Yes	Yes	9	9
26	1x56	8x54	s1p5_off	58.8898	0	No	No	Yes	No	7	6
27	1x53	8x54	s1p5_off	81.0069	0	Yes	No	Yes	No	9	6
28	1x56	1x60	s1p5_off	13.5366	0	No	No	Yes	No	7	6
29	1x56	I1x50	s1p5_off	43.473	0	No	No	Yes	No	7	8
30	2x40	I1x50	s1p5_off	32.2223	0	Yes	No	Yes	No	8	8
31	2x39	2x40	s1p5_off	28.5262	0	Yes	No	Yes	No	8	8
32	2x39	3x50	s1p5_off	22.8928	0	Yes	No	No	No	8	9
33	3x37	4x56	s1p5_off	36.1792	0	Yes	No	No	Yes	6	6
34	4x56	5x39	s1p5_off	36.8673	8.00549	No	Yes	Yes	Yes	6	7
35	5x39	E2.Y189	s1p5_off	42.2469	2.46385	Yes	Yes	Yes	Yes	7	5
36	3x29	E2.Y189	s1p5_off	33.4376	3.25551	Yes	Yes	Yes	Yes	5	5
37	3x37	5x47	s1p5_off	27.3127	0	Yes	No	Yes	No	6	8
38	3x40	5x47	s1p5_off	13.3221	0	No	No	Yes	No	8	8
39	6x31	6x34	s1p5_off	19.3416	0	No	No	Yes	No	4	7
40	3x50	6x31	s1p5_off	21.1145	0	No	No	No	No	9	4
41	6x58	E2.T184	s1p5_off	21.6918	2.01955	Yes	No	Yes	No	4	5
42	7x31	E2.T184	s1p5_off	24.7909	0	Yes	Yes	Yes	No	1	5
43	6x58	E2.V185	s1p5_off	11.0648	0	Yes	No	No	No	4	4
44	7x54	8x54	s1p5_off	14.2158	0	No	No	Yes	No	7	6
45	3x25	E2.Y189	s1p5_off	10.9969	3.12626	Yes	Yes	Yes	Yes	9	5
46	3x29	Lig	Shared	41.423	46.9505	Yes	Yes	Yes	Yes	5	0
47	3x25	NT.Y19	Shared	18.8233	35.5037	Yes	Yes	Yes	Yes	9	9
48	1x50	2x50	Shared	44.3112	11.8992	Yes	Yes	No	No	9	9
49	2x50	7x46	Shared	76.882	28.9684	No	No	No	No	9	9
50	1x53	2x47	Shared	20.7088	25.5675	Yes	No	Yes	No	9	9
51	1x53	7x50	Shared	40.5204	27.999	Yes	No	No	Yes	9	9
52	NT.H18	NT.L17	s1p5_on	0	13.846	Yes	Yes	No	No	8	3
53	E2.P187	NT.H18	s1p5_on	0	23.0794	Yes	No	Yes	Yes	4	8
54	E2.P187	NT.Y19	s1p5_on	6.68251	24.9132	Yes	No	Yes	Yes	4	9
55	3x25	3x29	s1p5_on	8.34286	40.8434	Yes	Yes	Yes	Yes	9	5
56	7x31	E3.R280	s1p5_on	0	11.6568	Yes	Yes	No	No	1	3
57	7x31	E3.C282	s1p5_on	6.34294	20.6075	Yes	Yes	Yes	Yes	1	4
58	6x57	E3.C282	s1p5_on	0	37.4424	No	No	Yes	Yes	5	4
59	6x54	6x57	s1p5_on	0	40.8676	No	No	No	No	5	5
60	6x54	6x55	s1p5_on	0	49.1478	No	No	No	No	5	6
61	6x51	6x55	s1p5_on	0	50.7553	No	No	No	No	7	6
62	6x51	Lig	s1p5_on	0	53.922	No	No	Yes	Yes	7	0
63	2x57	7x38	s1p5_on	0	18.1679	Yes	Yes	No	No	7	5
64	7x38	Lig	s1p5_on	1.70682	41.2877	No	No	Yes	Yes	5	0
65	7x42	7x46	s1p5_on	0	29.2431	No	No	No	No	7	9
66	7x38	7x42	s1p5_on	0	29.5743	No	No	No	No	5	7
67	6x47	7x45	s1p5_on	5.3671	10.1058	No	No	No	Yes	8	9
68	6x48	7x45	s1p5_on	5.33314	96.6476	Yes	No	No	Yes	9	9
69	3x36	6x48	s1p5_on	4.42701	99.8869	No	No	Yes	No	7	9
70	3x36	Lig	s1p5_on	0	100	No	No	Yes	Yes	7	0
71	1x50	2x51	s1p5_on	2.20189	12.3193	Yes	Yes	No	No	9	7
72	2x50	7x50	s1p5_on	0	16.7865	No	No	No	Yes	9	9
73	7x49	7x50	s1p5_on	0	26.7792	Yes	Yes	No	Yes	9	9
74	7x45	7x49	s1p5_on	0	35.7056	No	Yes	Yes	Yes	9	9
75	1x57	2x43	s1p5_on	0	15.7202	No	Yes	No	No	7	8
76	2x43	2x47	s1p5_on	0	18.1517	No	No	Yes	No	8	9
77	2x38	4x42	s1p5_on	0.625536	15.9625	No	Yes	Yes	Yes	5	6
78	2x42	4x42	s1p5_on	3.74071	53.5504	No	No	Yes	Yes	8	6
79	2x42	3x46	s1p5_on	6.16421	57.234	No	No	No	Yes	8	9
80	2x46	3x46	s1p5_on	7.25265	43.8565	Yes	Yes	No	Yes	9	9
81	2x46	3x43	s1p5_on	0	21.181	Yes	Yes	No	Yes	9	8
82	3x43	7x45	s1p5_on	0	61.0712	No	Yes	No	Yes	8	9
83	3x46	7x53	s1p5_on	0	18.1679	No	Yes	Yes	Yes	9	9
84	3x43	7x53	s1p5_on	0	43.4849	No	Yes	Yes	Yes	8	9
85	2x46	7x49	s1p5_on	7.42243	29.6066	Yes	Yes	Yes	Yes	9	9
86	3x38	4x53	s1p5_on	5.55297	10.0493	No	No	No	No	7	7
87	3x37	4x53	s1p5_on	6.46626	21.5849	Yes	No	No	No	6	7
88	3x37	Lig	s1p5_on	0	27.1347	Yes	No	Yes	Yes	6	0
89	3x34	4x53	s1p5_on	0	10.0493	Yes	No	No	No	5	7
90	3x40	Lig	s1p5_on	0	10.0493	No	No	Yes	Yes	8	0
91	3x50	7x53	s1p5_on	0	22.2635	No	No	Yes	Yes	9	9
92	3x50	5x58	s1p5_on	0	27.5063	No	No	No	Yes	9	9
93	5x65	6x33	s1p5_on	0	12.6666	No	Yes	No	No	8	8
94	6x33	6x37	s1p5_on	0	21.2376	No	No	No	No	8	8
95	5x58	6x37	s1p5_on	0	22.7886	No	Yes	No	No	9	8
96	4x42	4x43	s1p5_on	0	16.4634	Yes	Yes	No	No	6	1
97	4x42	4x45	s1p5_on	0	19.5735	Yes	Yes	No	No	6	5
98	6x61	E3.P278	s1p5_on	0	12.0123	Yes	No	No	No	5	3
99	6x61	E3.C282	s1p5_on	0.0125107	13.3371	Yes	No	Yes	Yes	5	4
100	5x47	6x52	s1p5_on	8.00865	13.9591	Yes	No	Yes	Yes	8	7
101	5x47	Lig	s1p5_on	0	15.8898	Yes	No	Yes	Yes	8	0
102	4x41	4x45	s1p5_on	0	11.6488	No	No	No	No	7	5
103	4x39	4x43	s1p5_on	0	12.6666	No	No	No	No	7	1
104	3x33	Lig	s1p5_on	0	24.6547	No	Yes	Yes	Yes	5	0
105	3x33	5x39	s1p5_on	0	18.2648	No	Yes	Yes	Yes	5	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
Lig	NT.Y19	s1p5_off	7.35	0	1	0	0	1
Lig	NT.K24	Shared	3.53	4.67	1	0	0	1
2x57	Lig	s1p5_off	10.28	0	1	0	1	0
2x60	Lig	Shared	8.6	11.82	1	0	1	0
2x61	Lig	s1p5_off	4.47	0	0	0	1	0
3x28	Lig	s1p5_off	4.57	0	1	1	1	0
3x29	Lig	Shared	14.12	9.65	1	1	1	0
3x32	Lig	Shared	7.47	0.99	1	0	1	0
E2.P187	Lig	s1p5_off	3.09	0	1	0	1	0
7x35	Lig	s1p5_off	5.95	0	0	5	1	0
7x38	Lig	Shared	19.95	7.33	0	0	1	0
7x39	Lig	s1p5_off	3.22	0	0	0	1	0
7x42	Lig	s1p5_off	6.2	0	1	0	1	0
NT.I15	NT.Y19	s1p5_off	3.63	0	1	0	2	1
3x25	NT.I15	s1p5_off	3.52	0	1	1	2	2
NT.K24	NT.Y19	s1p5_off	3.58	0	1	0	1	1
E1x50	NT.Y19	s1p5_off	3.75	0	1	1	2	1
E1x501	NT.Y19	Shared	5.86	3.52	1	1	2	1
3x25	NT.Y19	Shared	5.79	3.86	1	1	2	1
E2.P187	NT.Y19	Shared	12.52	25.03	1	0	1	1
NT.K24	NT.T22	Shared	6.01	3	1	0	1	2
E2.P187	NT.T22	s1p5_off	3.5	0	1	0	1	2
E2.P187	NT.K24	s1p5_off	5.02	0	1	0	1	1
E1x501	NT.L25	Shared	4.15	8.3	1	1	2	2
1x39	2x61	s1p5_off	3.27	0	0	0	2	1
1x39	7x42	s1p5_off	3.24	0	0	0	2	1
1x40	2x61	Shared	7.14	4.28	0	0	2	1
2x53	2x57	s1p5_off	5.34	0	0	0	2	1
2x53	7x46	s1p5_off	3.42	0	0	0	2	2
2x54	2x57	s1p5_off	4.35	0	0	0	2	1
2x57	3x32	s1p5_off	3.79	0	1	0	1	1
2x57	7x42	s1p5_off	7.18	0	1	0	1	1
2x60	3x28	Shared	9.64	3.62	1	0	1	1
2x60	3x29	s1p5_off	10.52	0	1	0	1	1
2x63	3x28	Shared	3.64	14.58	0	1	2	1
2x64	E1x50	s1p5_off	3.2	0	1	0	2	2
2x64	3x28	s1p5_off	9.22	0	1	0	2	1
3x28	E1x50	Shared	11.64	6.47	1	1	1	2
3x28	E1x52	s1p5_off	6.07	0	1	1	1	2
3x25	3x28	Shared	8	8	1	1	2	1
3x25	3x29	Shared	6.54	3.27	1	1	2	1
3x25	E2.Y189	Shared	4.82	5.79	1	1	2	2
3x28	3x29	s1p5_off	12.79	0	1	1	1	1
3x29	E2.L186	Shared	5.3	5.3	1	1	1	2
3x29	E2.Y189	Shared	3.37	12.35	1	1	1	2
3x33	E2.L186	s1p5_off	3.65	0	1	1	1	2
3x33	E2.Y189	Shared	9.28	4.13	1	1	1	2
3x36	5x47	s1p5_off	7.31	0	4	0	1	1
3x36	6x48	Shared	15.94	6.83	4	0	1	2
3x36	6x52	s1p5_off	3.65	0	4	0	1	2
3x37	4x53	Shared	6.4	3.2	0	0	1	2
3x37	4x56	s1p5_off	7.37	0	0	0	1	2
3x37	5x47	s1p5_off	6.49	0	0	0	1	1
3x40	5x47	s1p5_off	6.55	0	0	0	1	1
3x40	5x50	Shared	4.61	3.07	0	0	1	2
3x40	6x44	s1p5_off	3.93	0	0	0	1	2
4x56	5x39	Shared	4.69	1.17	1	0	2	2
4x56	5x43	s1p5_off	4.76	0	1	0	2	1
6x55	E2.V185	s1p5_off	4.47	0	0	0	2	2
E2.L186	E2.Y189	Shared	11.72	8.21	1	1	2	2
5x39	E2.Y189	Shared	3.97	5.96	1	1	2	2
5x39	5x43	s1p5_off	9.41	0	1	1	2	1
5x47	6x52	Shared	7.5	9.65	4	0	1	2
6x44	6x48	Shared	13.03	7.02	4	2	2	2
6x48	6x52	s1p5_off	13.03	0	4	2	2	2
6x48	7x41	s1p5_off	7.78	0	4	2	2	2
3x37	3x41	Shared	2.95	1.47	0	0	1	2
6x51	7x38	s1p5_off	2.77	0	0	0	1	1
7x34	E2.V185	s1p5_off	1.7	0	0	0	1	2
1x43	2x61	s1p5_off	1.64	0	0	0	2	1
E2.P187	NT.H18	s1p5_on	0	3.05	1	0	1	2
NT.L25	NT.Y19	s1p5_on	0	3.52	1	1	2	1
1x35	7x33	s1p5_on	0	6.53	0	5	2	2
1x35	7x35	s1p5_on	0	3.99	0	5	2	1
1x39	2x57	s1p5_on	0	8.06	0	0	2	1
2x56	3x32	s1p5_on	0	3.39	0	0	2	1
2x57	2x61	s1p5_on	0	10.88	1	0	1	1
2x57	7x38	s1p5_on	0	15.24	1	0	1	1
2x63	E1x50	s1p5_on	0	2.95	0	1	2	2
E1x50	E1x52	s1p5_on	0	5.9	1	1	2	2
3x25	E2.L186	s1p5_on	0	4.56	1	1	2	2
3x33	5x39	s1p5_on	0	9.28	1	1	1	2
3x33	Lig	s1p5_on	0	7.26	1	1	1	0
3x36	Lig	s1p5_on	0	7.33	4	0	1	0
3x37	Lig	s1p5_on	0	10.74	0	0	1	0
3x40	Lig	s1p5_on	0	7.89	0	0	1	0
5x43	Lig	s1p5_on	0	11.56	1	0	1	0
5x47	Lig	s1p5_on	0	4.84	4	0	1	0
6x51	6x55	s1p5_on	0	5.54	0	0	1	2
6x51	Lig	s1p5_on	0	6.42	0	0	1	0
7x33	7x35	s1p5_on	0	5.22	0	5	2	1
7x38	7x42	s1p5_on	0	2.83	0	0	1	1
7x42	7x46	s1p5_on	0	7.67	1	0	1	2
7x34	Lig	s1p5_on	0	2.09	0	0	1	0
1x39	7x39	s1p5_on	0	1.96	0	0	2	1
2x53	2x54	s1p5_on	0	1.95	0	0	2	2
1x36	2x61	s1p5_on	0	1.62	0	0	2	1
6x51	7x41	s1p5_on	0	1.58	0	0	1	2
2x61	2x64	s1p5_on	0	1.55	0	0	1	2
3x33	4x57	s1p5_on	0	1.51	1	1	1	2
1x43	2x57	s1p5_on	0	1.34	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	s1p5_off	7YXA-S1P₅-ONO-5430608
	s1p5_on	7EW1-S1P₅-Siponimod-Gi1/β1/γ2

Network Difference
Value	s1p5_off	s1p5_on
I_min	3.07	2.75
Number of Linked Nodes	252	228
Number of Specific Nodes	50 (19.84%)	26 (11.40%)
Number of Shared Nodes	202 (80.16%)	202 (88.60%)
Number of Links	299	248
Number of Specific Links	193 (64.55%)	142 (57.26%)
Number of Shared Links	106 (35.45%)	106 (42.74%)
Number of Hubs	47	31
Number of Specific Hubs	27 (57.45%)	11 (35.48%)
Number of Shared Hubs	20 (42.55%)	20 (64.52%)
Average % Shared Neighbours (Jaccard)	23.28
Average % Shared Neighbours (Otsuka)	30.24
Average % Shared Neighbours (Overlap Coefficient)	36.14
Average % Shared Cliques (k3-6)	52.54
Graphlets Similarity	0.605556

Paths Difference
Value	s1p5_off	s1p5_on
Number Of Nodes in MetaPath	46	58
Specific Nodes in MetaPath	25 (54.35%)	37 (63.79%)
Shared Nodes in MetaPath	202 (80.16%)	202 (80.16%)
Number Of Links MetaPath	51	60
Specific Links in MetaPath	45 (88.24%)	54 (90.00%)
Shared Links in MetaPath	106 (35.45%)	106 (35.45%)
Number of Shortest Paths	86770	27693
Length Of Smallest Path	3	3
Average Path Length	15.2146	11.5815
Length of Longest Path	32	25
Minimum Path Strength	1.32	1.13
Average Path Strength	6.00957	5.7908
Maximum Path Strength	19.625	14.445
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.926078	0.923708
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.57143	5
Average % Of Corr. Nodes	42.3295	54.4678
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	55.1428	42.1872
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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