Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Q24 5.81535
2R:R:R25 6.348594
3R:R:L37 4.816536
4R:R:F38 9.384507
5R:R:P39 1.6925406
6R:R:H41 6.3025437
7R:R:K47 7.925632
8R:R:D48 5.886532
9R:R:K52 8.6625433
10R:R:R54 6.4225432
11R:R:F65 6.19833632
12R:R:R66 5.75535
13R:R:F68 9.665637
14R:R:R69 5.932538
15R:R:E80 4.6345308
16R:R:S84 5.414306
17R:R:L87 6.2465306
18R:R:Y95 3.9865328
19R:R:D99 6.63667639
20R:R:K106 4.956534
21R:R:E109 4.995435
22R:R:F114 2.84595
23R:R:Q117 8.824596
24R:R:K119 4.062593
25R:R:I120 2.6493
26R:R:F128 6.9654343
27R:R:H134 5.4925494
28R:R:I135 5.6975404
29R:R:P136 4.555694
30R:R:V142 3.4575407
31R:R:Y161 8.1275404
32R:R:I162 4.0954136
33R:R:R185 5.01509
34R:R:Q193 5.00254199
35R:R:M197 3.7375407
36R:R:D199 6.6775457
37R:R:I200 4.1375458
38R:R:Y203 7.958555
39R:R:W208 6.81167629
40R:R:V209 2.7025428
41R:R:G210 3.3025428
42R:R:I223 3.1275405
43R:R:K225 6.39503
44R:R:F226 4.426526
45R:R:E229 6.7825425
46R:R:I235 3.1875427
47R:R:C236 4.875429
48R:R:D238 3.935428
49R:R:F239 5.14125826
50R:R:E257 4.63254363
51R:R:A264 2.925427
52R:R:V266 3.694527
53R:R:I267 4.3325427
54R:R:V268 3.8665196
55R:R:F270 3.51754197
56R:R:S271 2.765174
57R:R:G273 3.194174
58R:R:D275 5.4245175
59R:R:W293 9.4125408
60R:R:E297 6.01254198
61R:R:S302 3.995425
62R:R:L304 3.7454172
63R:R:I305 3.418524
64R:R:Y310 5.4125403
65R:R:F311 7.22423
66R:R:V314 2.992527
67R:R:F320 3.556506
68R:R:I327 4.81506
69R:R:F330 7.33438
70R:R:F333 6.1765337
71R:R:R340 6.98404
72R:R:F351 5.372536
73R:R:T355 4.435434
74R:R:F356 7.105438
75R:R:E399 6.06538
76R:R:N400 3.525434
77R:R:I401 3.41537
78R:R:P407 3.06431
79R:R:Y408 7.916533
80R:R:Y411 5.8775435
81R:R:H413 5.744507
82R:R:L414 5.07436
83R:R:Y418 8.43254377
84R:R:I434 5.784106
85R:R:K454 4.12754103
86R:R:V455 4.1354104
87R:R:E456 6.31754105
88R:R:W458 5.036676104
89R:R:Q459 7.7465107
90R:R:V460 2.565407
91R:R:H463 9.25105
92R:R:F469 3.446138
93R:R:N471 8.944136
94R:R:N472 5.68254374
95R:R:Q476 4.024133
96R:R:F479 7.0065138
97R:R:V486 3.66453
98R:R:Y489 6.185458
99R:R:I492 3.784525
100R:R:W494 5.065627
101R:R:S497 3.96253
102R:R:I503 7.036524
103R:R:F505 5.996524
104R:R:K506 3.93405
105R:R:Y511 6.1175455
106R:R:N512 6.57554
107R:R:V513 4.62667653
108R:R:K516 6.31452
109R:R:I523 4.65656
110R:R:E525 6.245454
111R:R:W530 4.73528
112R:R:R535 3.4575424
113R:R:V537 2.8425424
114R:R:G549 2.8325159
115R:R:C561 3.82529
116R:R:F563 10.46754387
117R:R:Y573 5.921676156
118R:R:S574 2.9575408
119R:R:C585 4.05754159
120R:R:F589 6.4645155
121R:R:N592 7.44254157
122R:R:N594 7.735403
123R:R:T596 5.924155
124R:R:E610 6.825407
125R:R:V633 4.194405
126R:R:F634 4.4925409
127R:R:F637 5.70754404
128R:R:I642 3.7925267
129R:R:N647 8.88479
130R:R:R648 4.61754418
131R:R:E649 4.2675407
132R:R:C660 2.505477
133R:R:F662 5.22754208
134R:R:F668 9.76409
135R:R:I669 1.895408
136R:R:E671 4.515404
137R:R:W675 5.63254423
138R:R:F684 9.44408
139R:R:S687 4.34476
140R:R:C691 3.0775478
141R:R:C694 3.2875476
142R:R:V697 3.33478
143R:R:K698 7.2075479
144R:R:L721 4.698576
145R:R:Q724 6.22478
146R:R:L730 2.835403
147R:R:T732 2.4154437
148R:R:Q735 7.4975409
149R:R:W742 5.0125459
150R:R:P748 3.5375409
151R:R:I763 5.615407
152R:R:E767 6.01407
153R:R:C781 2.0075407
154R:R:C787 3.07754448
155R:R:F788 2.4175408
156R:R:F792 3.25408
157R:R:E799 5.7408
158R:R:E803 6.825409
159R:R:F814 5.0645219
160R:R:V838 3.255407
161R:R:F846 4.456206
162R:R:F853 4.665409
163S:S:Q24 5.81545
164S:S:R25 6.3485114
165S:S:L37 4.816546
166S:S:F38 9.384507
167S:S:P39 1.6925406
168S:S:H41 6.3025447
169S:S:K47 7.925642
170S:S:D48 5.886542
171S:S:K52 8.6625443
172S:S:R54 6.4225442
173S:S:F65 6.19833642
174S:S:R66 5.75545
175S:S:F68 9.665647
176S:S:R69 5.932548
177S:S:E80 4.45318
178S:S:S84 5.414316
179S:S:L87 6.2465316
180S:S:Y95 6.4325408
181S:S:I97 6.5525448
182S:S:D99 6.63667649
183S:S:K106 4.956544
184S:S:E109 4.995445
185S:S:F114 2.845115
186S:S:K119 4.0625113
187S:S:D126 6.84493
188S:S:F128 5.26286793
189S:S:I135 5.6975404
190S:S:P136 4.5556114
191S:S:V142 3.4575407
192S:S:Y161 8.1275404
193S:S:I162 4.0954146
194S:S:R185 5.01509
195S:S:Q193 5.00254229
196S:S:M197 3.7375407
197S:S:D199 6.6775467
198S:S:I200 4.1375468
199S:S:Y203 7.958565
200S:S:W208 6.81167619
201S:S:V209 2.7025418
202S:S:G210 3.3025418
203S:S:I223 3.1275405
204S:S:K225 6.39503
205S:S:F226 4.426516
206S:S:E229 6.7825415
207S:S:I235 3.1875417
208S:S:C236 4.875419
209S:S:D238 3.935418
210S:S:F239 5.14125816
211S:S:E257 4.63254503
212S:S:A264 2.925417
213S:S:V266 3.694517
214S:S:I267 4.3325417
215S:S:V268 3.8665226
216S:S:F270 3.51754227
217S:S:S271 2.765184
218S:S:G273 3.194184
219S:S:D275 5.4245185
220S:S:W293 9.4125408
221S:S:E297 6.01254228
222S:S:S302 3.995415
223S:S:L304 3.7454182
224S:S:I305 3.418514
225S:S:Y310 5.4125403
226S:S:F311 7.22413
227S:S:V314 2.992517
228S:S:F320 3.556506
229S:S:I327 4.81506
230S:S:F330 7.33448
231S:S:F333 6.1765487
232S:S:R340 6.98404
233S:S:F351 5.372546
234S:S:T355 4.435444
235S:S:F356 7.105448
236S:S:E399 6.06548
237S:S:N400 3.525444
238S:S:I401 3.41547
239S:S:P407 3.06441
240S:S:Y408 7.916543
241S:S:Y411 5.8775445
242S:S:H413 5.744507
243S:S:L414 5.07446
244S:S:Y418 8.43254517
245S:S:I434 5.784126
246S:S:K454 4.12754123
247S:S:V455 4.1354124
248S:S:E456 6.31754125
249S:S:W458 5.036676124
250S:S:Q459 7.7465127
251S:S:V460 2.565407
252S:S:H463 9.25125
253S:S:F469 3.446148
254S:S:N471 8.944146
255S:S:N472 5.68254514
256S:S:Q476 4.024143
257S:S:F479 7.0065148
258S:S:V486 3.66463
259S:S:Y489 6.185468
260S:S:I492 3.784515
261S:S:W494 5.065617
262S:S:S497 3.96273
263S:S:I503 7.036514
264S:S:F505 5.996514
265S:S:K506 3.726515
266S:S:Y511 6.1175465
267S:S:N512 6.57564
268S:S:V513 4.62667663
269S:S:K516 6.31462
270S:S:I523 4.65666
271S:S:E525 6.245464
272S:S:W530 4.73518
273S:S:R535 3.4575414
274S:S:V537 2.8425414
275S:S:G549 2.8325169
276S:S:R551 3.84287
277S:S:K552 8.49254288
278S:S:C561 3.82519
279S:S:Y573 5.921676166
280S:S:S574 2.9575408
281S:S:C585 4.05754169
282S:S:F589 6.4645165
283S:S:N592 7.44254167
284S:S:N594 7.735403
285S:S:T596 5.924165
286S:S:E610 6.825407
287S:S:V633 4.194535
288S:S:F634 4.4925409
289S:S:F637 5.70754534
290S:S:I642 3.7925297
291S:S:N647 8.88489
292S:S:R648 4.61754548
293S:S:E649 4.2675407
294S:S:C660 2.505487
295S:S:F662 5.22754238
296S:S:F668 9.76409
297S:S:I669 1.895408
298S:S:E671 4.515404
299S:S:W675 5.63254553
300S:S:F684 9.44408
301S:S:S687 4.34486
302S:S:C691 3.0775488
303S:S:C694 3.2875486
304S:S:V697 3.33488
305S:S:K698 7.2075489
306S:S:L721 4.698586
307S:S:Q724 6.22488
308S:S:L730 2.835403
309S:S:T732 2.4154567
310S:S:Q735 7.4975409
311S:S:W742 5.0125589
312S:S:P748 3.5375409
313S:S:I763 5.615407
314S:S:E767 6.01407
315S:S:C781 2.0075407
316S:S:C787 3.07754578
317S:S:F788 2.4175408
318S:S:F792 5.6554608
319S:S:E799 5.7408
320S:S:E803 6.825409
321S:S:F814 5.0645249
322S:S:V838 3.255407
323S:S:F846 4.456236
324S:S:F853 4.665409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:L37 R:R:Q24 10.49935.32YesYes365
2R:R:L37 R:R:S113 22.43823YesNo064
3R:R:G36 R:R:S113 22.6253.71NoNo074
4R:R:G35 R:R:G36 22.81572.11NoNo087
5R:R:G35 R:R:T138 23.00863.64NoNo086
6R:R:F114 R:R:T138 23.20363.89YesNo056
7R:R:F114 R:R:K119 21.21632.48YesYes953
8R:R:H134 R:R:L91 12.65247.71YesNo046
9R:R:G30 R:R:L91 10.91791.71NoNo096
10R:R:G30 R:R:K29 10.06521.74NoNo093
11R:R:L157 R:R:L159 71.76075.54NoNo075
12R:R:L159 R:R:Y161 71.67815.86NoYes054
13R:R:I139 R:R:Y161 14.999719.34NoYes054
14R:R:K119 R:R:V115 86.26447.59YesNo035
15R:R:I120 R:R:V115 86.47181.54YesNo035
16R:R:I120 S:S:D126 11.792.8YesYes933
17R:R:I120 S:S:I120 1004.42YesNo033
18R:R:V460 R:R:Y161 13.22563.79YesYes074
19R:R:I427 R:R:V460 13.18793.07NoYes057
20S:S:I120 S:S:V115 99.98571.54NoNo035
21S:S:K119 S:S:V115 99.95617.59YesNo035
22S:S:F114 S:S:K119 23.96232.48YesYes1153
23R:R:L461 R:R:Y161 78.1053.52NoYes074
24R:R:L461 R:R:R465 77.99543.64NoNo075
25R:R:E481 R:R:R465 77.88552.33NoNo045
26R:R:D480 R:R:E481 77.77533.9NoNo074
27R:R:D480 R:R:Y514 76.76335.75NoNo074
28R:R:N512 R:R:Y514 75.38523.49YesNo544
29R:R:N512 R:R:V513 71.62462.96YesYes543
30R:R:A196 R:R:V513 66.65611.7NoYes083
31R:R:A196 R:R:F320 66.5364.16NoYes086
32R:R:F320 R:R:M197 64.90912.49YesYes067
33R:R:F226 R:R:M197 43.00634.98YesYes067
34R:R:M197 R:R:V268 21.43124.56YesYes076
35R:R:F226 R:R:V209 40.66752.62YesYes268
36R:R:V209 R:R:V266 20.15324.81YesYes287
37R:R:V266 R:R:W208 16.58012.45YesYes279
38R:R:F239 R:R:G210 16.10626.02YesYes268
39R:R:G210 R:R:V209 21.65521.84YesYes288
40R:R:G210 R:R:T211 21.85781.82YesNo085
41R:R:T211 R:R:V268 21.92381.59NoYes056
42R:R:C542 R:R:W208 13.55453.92NoYes099
43R:R:G210 R:R:I267 26.64063.53YesYes287
44R:R:I212 R:R:V269 17.63214.61NoNo065
45R:R:S271 R:R:V269 16.82881.62YesNo045
46R:R:C542 R:R:S543 12.58151.72NoNo098
47R:R:F563 R:R:S543 12.365817.18YesNo078
48R:R:I267 R:R:K291 18.02234.36YesNo076
49R:R:K291 R:R:W293 16.838125.53NoYes068
50R:R:D578 R:R:F563 10.39463.58NoYes3877
51R:R:D545 R:R:D578 10.190610.65NoNo057
52S:S:F114 S:S:T138 30.44333.89YesNo056
53S:S:G35 S:S:T138 30.24473.64NoNo086
54S:S:G35 S:S:G36 30.04682.11NoNo087
55S:S:G36 S:S:S113 29.84963.71NoNo074
56S:S:L37 S:S:S113 29.65523YesNo064
57S:S:L37 S:S:Q24 13.475.32YesYes465
58S:S:F38 S:S:Q24 10.407911.71YesYes075
59S:S:K119 S:S:L157 73.66744.23YesNo1137
60S:S:L157 S:S:L159 81.06755.54NoNo075
61S:S:L159 S:S:Y161 80.93425.86NoYes054
62S:S:K106 S:S:L37 15.31487.05YesYes446
63S:S:K106 S:S:K47 14.40652.87YesYes442
64S:S:V460 S:S:Y161 20.93243.79YesYes074
65S:S:I427 S:S:V460 21.53573.07NoYes057
66S:S:I427 S:S:S426 14.22441.55NoNo057
67S:S:L461 S:S:Y161 83.93613.52NoYes074
68S:S:L461 S:S:R465 83.82143.64NoNo075
69S:S:E481 S:S:R465 84.11962.33NoNo045
70S:S:D480 S:S:E481 83.99563.9NoNo074
71S:S:D480 S:S:Y514 82.89985.75NoNo074
72S:S:N512 S:S:Y514 81.413.49YesNo644
73S:S:N512 S:S:V513 77.31442.96YesYes643
74S:S:A196 S:S:V513 71.70131.7NoYes083
75S:S:A196 S:S:F320 71.56744.16NoYes086
76S:S:F320 S:S:M197 69.7082.49YesYes067
77S:S:F226 S:S:M197 46.15984.98YesYes067
78S:S:M197 S:S:V268 23.02494.56YesYes076
79S:S:F226 S:S:V209 43.62.62YesYes168
80S:S:V209 S:S:V266 21.4394.81YesYes187
81S:S:V266 S:S:W208 17.49372.45YesYes179
82S:S:G210 S:S:V209 23.13191.84YesYes188
83S:S:F239 S:S:G210 17.20066.02YesYes168
84S:S:T211 S:S:V268 23.4841.59NoYes056
85S:S:G210 S:S:T211 23.39651.82YesNo085
86S:S:C542 S:S:W208 14.28833.92NoYes099
87S:S:G210 S:S:I267 28.52773.53YesYes187
88S:S:I212 S:S:V269 18.78134.61NoNo065
89S:S:S271 S:S:V269 17.92681.62YesNo045
90S:S:C542 S:S:S543 13.25521.72NoNo098
91S:S:F563 S:S:S543 13.027417.18NoNo078
92S:S:I267 S:S:K291 19.26974.36YesNo076
93S:S:K291 S:S:W293 18.002125.53NoYes068
94S:S:D578 S:S:F563 10.90313.58NoNo2877
95S:S:D545 S:S:D578 10.731910.65NoNo057
96S:S:D545 S:S:T577 10.500610.12NoNo055
97S:S:A548 S:S:T577 10.26891.68NoNo045
98R:R:K106 R:R:L37 11.09617.05YesYes346
99R:R:K106 R:R:K47 10.2672.87YesYes342
100R:R:K119 R:R:L157 68.66084.23YesNo937
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7E6U
Class C
SubFamily Ion
Type Calcium-sensing
SubType CaS
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 6
Date 2021-09-22
D.O.I. 10.7554/eLife.68578
Net Summary
Imin 1.54
Number of Linked Nodes 1487
Number of Links 1887
Number of Hubs 324
Number of Links mediated by Hubs 1139
Number of Communities 61
Number of Nodes involved in Communities 502
Number of Links involved in Communities 714
Path Summary
Number Of Nodes in MetaPath 101
Number Of Links MetaPath 100
Number of Shortest Paths 1233499
Length Of Smallest Path 3
Average Path Length 28.7142
Length of Longest Path 68
Minimum Path Strength 1.14
Average Path Strength 4.87832
Maximum Path Strength 30.46
Minimum Path Correlation 0.73
Average Path Correlation 0.996564
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 13.3333
Average % Of Corr. Nodes 72.8148
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.3541
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41180
Sequence
>7E6U_Chain_R
DQRAQKKGD IILGGLFPI HFGVAAKDQ DLKSRFRGF RWLQAMIFA 
IEEINSSPA LLPNLTLGY RIFDSKALE ATLSFVAQN KIDSLNLDE 
FCNCSEHIP STIAVVGAT GSGVSTAVA NLLGLFYIP RTIPNDEHQ 
ATAMADIIE YFRWNWVGT IAADDDYGR PGIEKFREE AEERDICID 
FSELISQYS DEEEIQHVV EVIQNSTAK VIVVFSSGP DLEPLIKEI 
VRRNITGKI WLASEAWAS SSLIAMPQY FHVVGGTIG FALKAGQIP 
GFREFLKKV HPRKSVHNG FAKEFWEET FNPLCTGDE NISSVETPY 
IDYTHLRIS YNVYLAVYS IAHALQDIY TCLPGRGLF TNGSCADIK 
KVEAWQVLK HLRHLNFTN NMGEQVTFD ECGDLVGNY SIINWHLSP 
EDGSIVFKE VGYYNVYAK KGERLFINE EKILWSGFS REVPFSNCS 
RDCLAGTRK GIIEGEPTC CFECVECPD GEYSDETDA SACNKCPDD 
FWSNENHTS CIAKEIEFL SWTEPFGIA LTLFAVLGI FLTAFVLGV 
FIKFRNTPI VKATNRELS YLLLFSLLC CFSSSLFFI GEPQDWTCR 
LRQPAFGIS FVLCISCIL VKTNRVLLV FEAKIPTSF HRKWWGLNL 
QFLLVFLCT FMQIVICVI WLYTAPPSS YRNQELEDE IIFITCHEG 
SLMALGFLI GYTCLLAAI CFFFAFKSR KLPENFNEA KFITFSMLI 
FFIVWISFI PAYASTYGK FVSAVEVIA ILAASFGLL ACIFFNKIY 
IILFKPSR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP41180
Sequence
>7E6U_Chain_S
DQRAQKKGD IILGGLFPI HFGVAAKDQ DLKSRFRGF RWLQAMIFA 
IEEINSSPA LLPNLTLGY RIFDSKALE ATLSFVAQN KIDSLNLDE 
FCNCSEHIP STIAVVGAT GSGVSTAVA NLLGLFYIP RTIPNDEHQ 
ATAMADIIE YFRWNWVGT IAADDDYGR PGIEKFREE AEERDICID 
FSELISQYS DEEEIQHVV EVIQNSTAK VIVVFSSGP DLEPLIKEI 
VRRNITGKI WLASEAWAS SSLIAMPQY FHVVGGTIG FALKAGQIP 
GFREFLKKV HPRKSVHNG FAKEFWEET FNPLCTGDE NISSVETPY 
IDYTHLRIS YNVYLAVYS IAHALQDIY TCLPGRGLF TNGSCADIK 
KVEAWQVLK HLRHLNFTN NMGEQVTFD ECGDLVGNY SIINWHLSP 
EDGSIVFKE VGYYNVYAK KGERLFINE EKILWSGFS REVPFSNCS 
RDCLAGTRK GIIEGEPTC CFECVECPD GEYSDETDA SACNKCPDD 
FWSNENHTS CIAKEIEFL SWTEPFGIA LTLFAVLGI FLTAFVLGV 
FIKFRNTPI VKATNRELS YLLLFSLLC CFSSSLFFI GEPQDWTCR 
LRQPAFGIS FVLCISCIL VKTNRVLLV FEAKIPTSF HRKWWGLNL 
QFLLVFLCT FMQIVICVI WLYTAPPSS YRNQELEDE IIFITCHEG 
SLMALGFLI GYTCLLAAI CFFFAFKSR KLPENFNEA KFITFSMLI 
FFIVWISFI PAYASTYGK FVSAVEVIA ILAASFGLL ACIFFNKIY 
IILFKPSR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7DD5CIonCalcium-sensingCaSGallus gallusCaCa; Ca; Tryptophan; NPS-2143-3.22021-06-1610.1126/sciadv.abg1483
7DD6CIonCalcium-sensingCaSGallus gallusCaCa; Ca; Tryptophan-3.22021-06-1610.1126/sciadv.abg1483
7DD7CIonCalcium-sensingCaSGallus gallusCaCa; Ca; Tryptophan; Evocalcet-3.22021-06-1610.1126/sciadv.abg1483
7DTTCIonCalcium-sensingCaSHomo sapiensCaCa-3.82021-03-1010.1038/s41422-021-00474-0
7DTUCIonCalcium-sensingCaSHomo sapiens-Tryptophan-4.42021-03-1010.1038/s41422-021-00474-0
7DTVCIonCalcium-sensingCaSHomo sapiensCaCa; Tryptophan-3.52021-03-1010.1038/s41422-021-00474-0
7DTWCIonCalcium-sensingCaSHomo sapiens---4.52021-03-1010.1038/s41422-021-00474-0
7E6TCIonCalcium-sensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-32021-09-2210.7554/eLife.68578
7E6UCIonCalcium-sensingCaSHomo sapiens---62021-09-2210.7554/eLife.68578
7M3ECIonCalcium-sensingCaSHomo sapiens-Ca; Ca; Tryptophan; NPS-2143; PO4-3.22021-06-3010.1038/s41586-021-03691-0
7M3FCIonCalcium-sensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4-2.82021-06-3010.1038/s41586-021-03691-0
7M3GCIonCalcium-sensingCaSHomo sapiens-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4-2.52021-06-3010.1038/s41586-021-03691-0
7M3JCIonCalcium-sensingCaSHomo sapiens-NPS-2143; PO4-4.12021-06-3010.1038/s41586-021-03691-0
7SILCIonCalcium-sensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-2.72022-01-1910.1073/pnas.2115849118
7SIMCIonCalcium-sensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-2.72022-01-1910.1073/pnas.2115849118
7SINCIonCalcium-sensingCaSHomo sapiens-NPS-2143-5.92022-01-1910.1073/pnas.2115849118
8SZFCIonCalcium-sensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-2.82024-02-0710.1038/s41586-024-07055-2
8SZGCIonCalcium-sensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWchim(NtGi1-Gq)/&β;1/&γ;23.62024-02-0710.1038/s41586-024-07055-2
8SZHCIonCalcium-sensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWGi1/&β;1/&γ;23.12024-02-0710.1038/s41586-024-07055-2
8SZICIonCalcium-sensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWGi3/&β;1/&γ;23.52024-02-0710.1038/s41586-024-07055-2
8WPGCIonCalcium-sensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca-2.72023-11-2210.1038/s41422-023-00892-2
8WPUCIonCalcium-sensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(NtGi2L-Gs-CtGq)/&β;1/&γ;23.12023-11-2210.1038/s41422-023-00892-2
9AXFCIonCalcium-sensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.52024-04-1710.1038/s41586-024-07331-1
9AYFCIonCalcium-sensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4Gi1/&β;1/&γ;23.62024-04-1710.1038/s41586-024-07331-1




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Download 7E6U.zip



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