Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1S:S:F38 9.455427
2S:S:P39 7.8675426
3S:S:I40 9.24425
4S:S:H41 8.462527
5S:S:F42 11.85254263
6S:S:L51 4.842556
7S:S:P55 10.72456
8S:S:R62 7.02754264
9S:S:Y63 8.06429725
10S:S:F65 8.516522
11S:S:R66 8.946525
12S:S:F68 9.606527
13S:S:R69 8.172528
14S:S:W70 8.02925
15S:S:L71 5.788524
16S:S:Q72 7.158527
17S:S:M74 6.082528
18S:S:I81 6.1325409
19S:S:L88 5.8275409
20S:S:L93 4.865409
21S:S:Y95 10.8325408
22S:S:R96 6.512584
23S:S:I97 6.6875428
24S:S:F98 8.56667684
25S:S:D99 7.8625429
26S:S:S113 5.84484
27S:S:F114 6.62167685
28S:S:I135 4.305404
29S:S:T145 6.952525
30S:S:T151 5.1275425
31S:S:F160 7.768587
32S:S:I162 4.68586
33S:S:P163 4.3075408
34S:S:Q164 6.9625488
35S:S:Y167 8.434528
36S:S:R172 6.8475424
37S:S:L173 6.514525
38S:S:F180 7.856525
39S:S:F183 8.326508
40S:S:R185 7.844529
41S:S:I187 4.66506
42S:S:N189 6.0325428
43S:S:D190 9.1125428
44S:S:Q193 7.9925429
45S:S:F204 8.406567
46S:S:W206 8.265669
47S:S:W208 10.43639
48S:S:T211 6.35254155
49S:S:D217 4.6125426
50S:S:Y218 7.73827
51S:S:K225 5.865403
52S:S:R227 7.8445154
53S:S:E229 8.774315
54S:S:R233 8.1365314
55S:S:F239 5.38536
56S:S:V258 6.5375434
57S:S:V266 8.1225467
58S:S:I267 5.775437
59S:S:F270 8.502527
60S:S:P274 4.3225403
61S:S:L276 6.8575435
62S:S:I280 6.04405
63S:S:E282 5.5854236
64S:S:R286 7.3485234
65S:S:W299 7.64637
66S:S:L304 8.9754262
67S:S:Y310 7.1825323
68S:S:F311 10.06403
69S:S:F320 6.1925406
70S:S:I327 7.3175426
71S:S:F330 8.718528
72S:S:R331 7.39404
73S:S:F333 8.4675407
74S:S:L334 7.984526
75S:S:N345 4.22628
76S:S:F347 7.536525
77S:S:E350 8.7575425
78S:S:F351 10.3583626
79S:S:W352 15.2625428
80S:S:T355 8424
81S:S:R392 5.7425401
82S:S:E399 11.34428
83S:S:Y408 9.47333623
84S:S:Y411 11.5625425
85S:S:L414 7.3175426
86S:S:R415 7.78405
87S:S:S417 5.805426
88S:S:Y418 10.0165147
89S:S:Y421 9.692528
90S:S:F444 5.69254103
91S:S:I452 4.47254333
92S:S:V455 3.074334
93S:S:W458 10.085104
94S:S:Q459 8.8054107
95S:S:L461 5.62754107
96S:S:K462 5.0285104
97S:S:H463 7.3025405
98S:S:F469 10.124148
99S:S:N471 5.6965146
100S:S:D484 8.3875428
101S:S:N488 9.464174
102S:S:N493 7.3275469
103S:S:W494 8.02857737
104S:S:H495 9.41407
105S:S:S497 2.7925403
106S:S:Y511 9.425405
107S:S:N512 7.55174
108S:S:Y514 6.345174
109S:S:L521 5.62465
110S:S:I528 8.52467
111S:S:W530 9.04875868
112S:S:V537 5.6925464
113S:S:P538 7.98468
114S:S:T550 4.26254186
115S:S:K552 12.6254188
116S:S:P559 5.825436
117S:S:C562 6.4375439
118S:S:F563 11.28754187
119S:S:H595 4.2925405
120S:S:W608 7.5375405
121S:S:E610 5.491676167
122S:S:F612 7.05254168
123S:S:F662 8.824388
124S:S:F668 10.1525409
125S:S:P672 5.66754399
126S:S:W675 5.3875403
127S:S:R680 9.125398
128S:S:Q681 6.8725479
129S:S:F684 10.788578
130S:S:F688 6.40667608
131S:S:I695 4.8325407
132S:S:L723 3.774217
133S:S:Q724 7.9454218
134S:S:Q735 6.708509
135S:S:W742 6.20333679
136S:S:N753 3.955407
137S:S:I760 6.72254165
138S:S:I761 8.1154277
139S:S:F762 6.62754167
140S:S:L773 5.68333678
141S:S:L776 5.63408
142S:S:F801 7.84254209
143S:S:I807 4.7525409
144S:S:F809 7.1654409
145S:S:F814 8.298579
146S:S:W818 10.5367679
147S:S:F821 8.56833679
148S:S:Y825 11.2125479
149S:S:F832 6.9465165
150S:S:E837 12.9375479
151S:S:L849 4.0525408
152S:S:F853 9.72254199
153S:S:R866 9.65754206
154S:S:N867 8.40754209
155R:R:L37 4.5325406
156R:R:F38 9.455417
157R:R:P39 7.8675416
158R:R:I40 7.6475415
159R:R:H41 7.316517
160R:R:F42 12.654283
161R:R:L51 5.8054106
162R:R:C60 6.4675417
163R:R:R62 7.87254284
164R:R:Y63 7.58571715
165R:R:F65 7.998512
166R:R:R66 9.864515
167R:R:F68 9.166517
168R:R:R69 7.11667618
169R:R:W70 8.83875815
170R:R:L71 5.33333614
171R:R:Q72 7.6575417
172R:R:I75 6.1075414
173R:R:I81 7.7409
174R:R:L88 5.135409
175R:R:Y95 9.9325408
176R:R:R96 7.5404
177R:R:I97 6.0825408
178R:R:F98 9.348504
179R:R:F114 7.094505
180R:R:T145 6.2715
181R:R:T151 4.7575415
182R:R:F160 8.515407
183R:R:I162 4.15406
184R:R:P163 4.102508
185R:R:Y167 9.025418
186R:R:R172 6.574514
187R:R:L173 7405
188R:R:L174 8.715417
189R:R:S175 5.5275418
190R:R:F180 8.522515
191R:R:F183 8.382518
192R:R:R185 7.81333619
193R:R:I187 4.2775416
194R:R:N189 6.18518
195R:R:Q193 7.11833619
196R:R:F204 8.17333697
197R:R:W206 7.62799
198R:R:W208 9.398577139
199R:R:Y218 8.05167617
200R:R:K225 8.2275403
201R:R:R227 7.8325154
202R:R:E229 10.32405
203R:R:R233 9.8775404
204R:R:F239 5.78254136
205R:R:V266 7.74497
206R:R:F270 6.925417
207R:R:D275 5.4925405
208R:R:L276 7.89445
209R:R:L279 5.0425405
210R:R:E297 8.565418
211R:R:W299 8.04167647
212R:R:I305 6.25544
213R:R:Y310 6.66543
214R:R:F311 7.605403
215R:R:F320 6.658506
216R:R:I327 5.944516
217R:R:F330 7.82618
218R:R:F333 7.725407
219R:R:L334 9.2875416
220R:R:N345 4.15618
221R:R:F347 6.9975415
222R:R:E350 6.6275415
223R:R:F351 10.315616
224R:R:W352 12.724518
225R:R:E353 6.125417
226R:R:T355 7.35414
227R:R:F356 12.79418
228R:R:C395 5.5275419
229R:R:E399 9.026518
230R:R:Y408 9.475613
231R:R:Y411 12.59415
232R:R:L414 7.6225416
233R:R:I416 8.6875414
234R:R:S417 5.475416
235R:R:Y418 8.36667617
236R:R:Y421 9.058518
237R:R:Q432 5.89254437
238R:R:Y435 5.714433
239R:R:F444 4.89453
240R:R:E456 7.835455
241R:R:W458 10.1983654
242R:R:Q459 7.598557
243R:R:L461 5.93457
244R:R:K462 7.21454
245R:R:H463 7.6225405
246R:R:N471 5.58416
247R:R:M473 5.01414
248R:R:D484 9.0175418
249R:R:N493 6.788599
250R:R:W494 8.48286747
251R:R:S497 2.9775403
252R:R:Y511 8.62405
253R:R:N512 7.6165244
254R:R:Y514 6.756244
255R:R:E525 6.8225494
256R:R:W530 8.57667998
257R:R:V537 5.836594
258R:R:P538 7.98498
259R:R:K552 8.5625408
260R:R:E558 7.19754135
261R:R:C582 5.70754369
262R:R:D588 5.14126
263R:R:W590 7.573336126
264R:R:S591 3.334128
265R:R:H595 4.64405
266R:R:T596 3.49405
267R:R:E610 8.0525407
268R:R:I624 3.1025405
269R:R:V633 4.7775405
270R:R:F634 5.775409
271R:R:T640 6.84259
272R:R:I642 7.55754257
273R:R:F662 8.9954468
274R:R:F668 10.9554119
275R:R:R680 8.5325118
276R:R:Q681 6.8156119
277R:R:F684 10.03336118
278R:R:F688 6.77408
279R:R:F706 7.195409
280R:R:W719 5.758506
281R:R:Q724 12.25754488
282R:R:F733 4.48754494
283R:R:W742 6.146676119
284R:R:I760 7.2654225
285R:R:I761 7.1465127
286R:R:F762 8.47227
287R:R:L773 5.14754118
288R:R:Y779 7.38254309
289R:R:F788 5.425408
290R:R:F801 6.11409
291R:R:F814 8.0245119
292R:R:F815 5.84407
293R:R:W818 15.6054119
294R:R:F821 4.5525419
295R:R:P823 4.42409
296R:R:L849 4.4025408
297R:R:F853 7.048336479
298R:R:I860 6.23754259
299R:R:N867 10.234259
300H:H:?4 17.48336170
301H:H:?6 18.9367630
302H:H:?8 20.28336240
303H:H:?1 17.04711730
304X:X:?1 7.429091120
305X:X:?2 10.16620
306X:X:?3 14.4681070
307W:W:?1 8.4031010
308W:W:?2 9.365610
309I:I:?4 6.3375410
310W:W:?3 15.21569110
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1S:S:D217 S:S:R220 21.4443.57YesNo066
2R:R:L173 S:S:R220 18.578813.36YesNo056
3S:S:S147 S:S:S171 18.34774.89NoNo287
4S:S:Y218 X:X:?1 12.340622.76YesYes270
5S:S:D217 S:S:L173 19.96584.07YesYes265
6S:S:F320 S:S:Q193 10.32459.37YesYes069
7S:S:D238 S:S:W208 36.261822.33NoYes389
8S:S:D238 S:S:F239 36.2323.58NoYes386
9S:S:F239 S:S:I267 35.13863.77YesYes367
10S:S:I259 S:S:I267 32.69772.94NoYes067
11S:S:I212 S:S:I259 32.69512.94NoNo066
12S:S:I212 S:S:I243 32.68684.42NoNo065
13S:S:I243 S:S:S271 32.68534.64NoNo054
14S:S:A214 S:S:S271 32.68433.42NoNo054
15S:S:A214 S:S:D216 29.04654.63NoNo056
16S:S:D216 S:S:Y218 29.04183.45NoYes067
17S:S:C542 S:S:W208 36.049120.89NoYes399
18R:R:L173 R:R:S171 14.42414.5YesNo057
19R:R:S147 R:R:S171 14.42624.89NoNo087
20R:R:F270 R:R:M197 21.46848.71YesNo077
21R:R:M197 R:R:V268 34.75646.09NoNo076
22R:R:F226 R:R:V268 33.697911.8NoNo066
23S:S:C542 S:S:S543 36.2993.44NoNo098
24S:S:F563 S:S:S543 36.30556.61YesNo078
25S:S:C546 S:S:F563 1002.79NoYes1897
26S:S:C546 S:S:T550 99.91213.38NoYes1896
27S:S:E567 S:S:T550 99.50238.47NoYes046
28S:S:E567 S:S:H595 99.4694.92NoYes045
29S:S:F563 S:S:K552 64.876429.78YesYes1878
30R:R:I554 S:S:K552 65.15182.91NoYes038
31R:R:I554 S:S:I554 65.1544.42NoNo033
32R:R:K552 S:S:I554 65.18012.91YesNo083
33S:S:H595 S:S:S591 97.56192.79YesNo058
34S:S:G571 S:S:S591 97.52713.71NoNo078
35S:S:G571 S:S:W590 97.49239.85NoNo076
36S:S:D758 S:S:W590 97.248313.4NoNo046
37S:S:E757 S:S:I760 97.14345.47NoYes045
38S:S:D758 S:S:E757 97.21343.9NoNo044
39S:S:E604 S:S:I760 96.68198.2NoYes1665
40S:S:E604 S:S:K831 96.7924.05NoNo1669
41S:S:E610 S:S:K831 48.18239.45YesNo1679
42S:S:E610 S:S:F612 46.6524.66YesYes1678
43S:S:F612 S:S:F832 46.87049.65YesYes1685
44S:S:F832 S:S:K831 48.57459.93YesNo1659
45S:S:F612 S:S:L616 19.07319.74YesNo088
46S:S:A835 S:S:F612 74.4094.16NoYes088
47S:S:L616 S:S:V838 18.95688.94NoNo087
48S:S:F684 S:S:F688 14.785210.72YesYes088
49S:S:F684 S:S:I841 14.4917.58YesNo089
50S:S:I841 S:S:S665 18.38614.64NoNo098
51S:S:S665 S:S:V838 18.84166.46NoNo087
52S:S:M811 S:S:S810 12.00523.07NoNo099
53S:S:L848 S:S:S810 12.24063NoNo079
54S:S:F688 S:S:L848 12.36276.09YesNo087
55R:R:P823 S:S:A835 74.30933.74YesNo098
56R:R:P823 S:S:V836 14.09395.3YesNo098
57S:S:F821 S:S:V836 13.98095.24YesNo098
58S:S:F821 X:X:?3 10.8174.72YesYes790
59R:R:I822 R:R:P823 63.15453.39NoYes079
60R:R:I822 W:W:?3 62.81934.42NoYes070
61R:R:F814 W:W:?3 36.59483.77YesYes1190
62R:R:F814 R:R:F815 17.37169.65YesYes097
63R:R:F788 R:R:F815 17.0195.36YesYes087
64R:R:T145 W:W:?1 10.54775.3YesYes150
65R:R:S147 W:W:?1 12.92756.48NoYes180
66R:R:R66 W:W:?1 29.6656.12YesYes150
67R:R:L334 R:R:Y408 16.278711.72YesYes163
68R:R:L334 R:R:R69 16.49793.64YesYes168
69R:R:R66 R:R:R69 21.99925.33YesYes158
70R:R:F351 R:R:Y408 11.977717.54YesYes163
71R:R:I81 R:R:Y425 18.324414.51YesNo098
72R:R:F330 R:R:R69 17.43484.28YesYes188
73R:R:Y421 R:R:Y425 13.508417.87YesNo188
74R:R:I327 R:R:Y421 15.861410.88YesYes168
75R:R:F330 R:R:I327 10.30617.54YesYes186
76R:R:I327 R:R:L414 14.37544.28YesYes166
77R:R:L414 R:R:S417 14.76296.01YesYes166
78R:R:S417 R:R:W70 11.32193.71YesYes165
79R:R:I416 W:W:?2 18.09836.57YesYes140
80R:R:E297 W:W:?1 29.08610.48YesYes180
81R:R:E297 R:R:Q193 51.84335.1YesYes189
82R:R:F320 R:R:Q193 39.789812.88YesYes069
83R:R:F320 R:R:I200 26.17833.77YesNo068
84R:R:I200 R:R:L521 26.17055.71NoNo085
85R:R:I201 R:R:I235 33.27625.89NoNo067
86R:R:A230 R:R:I235 33.28866.5NoNo067
87R:R:A230 R:R:F226 33.30524.16NoNo066
88R:R:F204 R:R:W206 28.10215.03YesYes979
89R:R:F204 R:R:I523 28.53473.77YesNo076
90R:R:I523 R:R:L521 28.58858.56NoNo065
91R:R:I201 R:R:V209 48.04026.14NoNo068
92R:R:V266 R:R:W206 14.8913.48YesYes979
93R:R:D238 R:R:F239 65.44273.58NoYes1386
94R:R:F239 R:R:G210 63.69049.03YesNo068
95R:R:G210 R:R:V209 63.72293.68NoNo088
96R:R:D238 R:R:W208 65.433718.98NoYes1389
97R:R:C542 R:R:W208 65.240318.28NoYes1399
98R:R:F356 R:R:T355 13.313911.67YesYes184
99R:R:F563 R:R:S543 65.34275.28NoNo078
100R:R:F563 R:R:K552 65.332921.09NoYes078
101R:R:F853 R:R:I852 34.3087.54YesNo099
102R:R:I695 R:R:I852 34.6522.94NoNo079
103R:R:C787 R:R:I695 37.47523.27NoNo087
104R:R:C787 R:R:M811 48.9936.48NoNo089
105R:R:I692 R:R:M811 32.92058.75NoNo079
106R:R:F688 R:R:I692 37.8885.02YesNo087
107R:R:F684 R:R:F688 19.20447.5YesYes088
108R:R:F684 W:W:?3 19.964316.04YesYes1180
109R:R:F688 R:R:F814 19.158511.79YesYes089
110R:R:F788 R:R:M811 16.43374.98YesNo089
111R:R:I857 R:R:V633 12.51744.61NoYes085
112R:R:F634 R:R:F853 12.55797.5YesYes099
113R:R:F790 R:R:L696 10.1194.87NoNo078
114R:R:C787 R:R:L696 11.19786.35NoNo088
115S:S:L173 S:S:S171 18.29834.5YesNo257
116R:R:C542 R:R:S543 65.35573.44NoNo098
117R:R:F270 R:R:Q193 13.24744.68YesYes179
118R:R:F320 R:R:M197 13.3098.71YesNo067
119R:R:E297 R:R:I416 22.6754.1YesYes184
120R:R:I201 R:R:W206 14.79564.7NoYes069
121R:R:V209 R:R:V266 15.71676.41NoYes087
122S:S:S147 S:S:Y218 11.52015.09NoYes287
123R:R:R69 W:W:?2 13.47569.78YesYes180
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F42 S:S:R62 5.34 26 Yes Yes 3 4 1 2
S:S:F42 S:S:N64 20.54 26 Yes No 3 4 1 2
S:S:F42 S:S:L304 17.05 26 Yes Yes 3 2 1 2
M:M:?1 S:S:F42 4.48 0 No Yes 0 3 0 1
S:S:L304 S:S:R62 7.29 26 Yes Yes 2 4 2 2
S:S:R66 S:S:W70 13 2 Yes Yes 5 5 2 2
S:S:R66 X:X:?1 6.99 2 Yes Yes 5 0 2 1
S:S:T145 S:S:W70 6.06 2 Yes Yes 5 5 2 2
S:S:I416 S:S:W70 19.97 2 No Yes 4 5 2 2
S:S:W70 X:X:?1 5.73 2 Yes Yes 5 0 2 1
S:S:T145 X:X:?1 5.3 2 Yes Yes 5 0 2 1
S:S:S147 S:S:Y218 5.09 2 No Yes 8 7 2 2
S:S:S147 X:X:?1 6.48 2 No Yes 8 0 2 1
S:S:A168 X:X:?1 3.4 0 No Yes 5 0 2 1
S:S:S170 X:X:?1 7.56 0 No Yes 7 0 2 1
S:S:A298 S:S:Y218 4 2 No Yes 6 7 2 2
S:S:Y218 X:X:?1 22.76 2 Yes Yes 7 0 2 1
S:S:G273 S:S:S302 3.71 0 No No 4 5 2 1
S:S:E297 X:X:?1 6.67 0 No Yes 8 0 2 1
S:S:A298 X:X:?1 9.06 2 No Yes 6 0 2 1
M:M:?1 S:S:S302 5.52 0 No No 0 5 0 1
S:S:I416 X:X:?1 4.11 2 No Yes 4 0 2 1
M:M:?1 X:X:?1 3.66 0 No Yes 0 0 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:P39 S:S:W70 5.4 2 Yes Yes 6 5 2 1
S:S:P39 S:S:T145 10.49 2 Yes Yes 6 5 2 1
I:I:?1 S:S:P39 9.06 2 No Yes 0 6 2 2
M:M:?1 S:S:F42 4.48 0 No Yes 0 3 1 2
S:S:R66 S:S:R69 5.33 2 Yes Yes 5 8 1 2
S:S:R66 S:S:W70 13 2 Yes Yes 5 5 1 1
S:S:R66 X:X:?1 6.99 2 Yes Yes 5 0 1 0
S:S:R66 X:X:?2 16.77 2 Yes Yes 5 0 1 2
S:S:G67 S:S:W70 5.63 0 No Yes 4 5 2 1
S:S:R69 S:S:S417 6.59 2 Yes Yes 8 6 2 2
S:S:R69 X:X:?2 13.98 2 Yes Yes 8 0 2 2
S:S:T145 S:S:W70 6.06 2 Yes Yes 5 5 1 1
S:S:W70 S:S:Y167 4.82 2 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 19.97 2 No Yes 4 5 1 1
S:S:S417 S:S:W70 3.71 2 Yes Yes 6 5 2 1
S:S:W70 X:X:?1 5.73 2 Yes Yes 5 0 1 0
S:S:W70 X:X:?2 7.86 2 Yes Yes 5 0 1 2
S:S:T145 S:S:Y167 7.49 2 Yes Yes 5 8 1 2
S:S:T145 X:X:?1 5.3 2 Yes Yes 5 0 1 0
I:I:?1 S:S:T145 5.42 2 No Yes 0 5 2 1
S:S:S147 S:S:S171 4.89 2 No No 8 7 1 2
S:S:S147 S:S:Y218 5.09 2 No Yes 8 7 1 1
S:S:S147 X:X:?1 6.48 2 No Yes 8 0 1 0
S:S:A168 X:X:?1 3.4 0 No Yes 5 0 1 0
S:S:I187 S:S:S170 6.19 0 Yes No 6 7 2 1
S:S:D190 S:S:S170 11.78 2 Yes No 8 7 2 1
S:S:S170 X:X:?1 7.56 0 No Yes 7 0 1 0
S:S:I187 S:S:L322 5.71 0 Yes No 6 4 2 2
S:S:D190 S:S:Q193 11.75 2 Yes Yes 8 9 2 2
S:S:D190 S:S:Y218 5.75 2 Yes Yes 8 7 2 1
S:S:D190 S:S:F270 7.17 2 Yes Yes 8 7 2 2
S:S:F270 S:S:Q193 7.03 2 Yes Yes 7 9 2 2
S:S:E297 S:S:Q193 3.82 0 No Yes 8 9 1 2
S:S:D216 S:S:Y218 3.45 0 No Yes 6 7 2 1
S:S:G219 S:S:Y218 4.35 0 No Yes 7 7 2 1
S:S:F270 S:S:Y218 11.35 2 Yes Yes 7 7 2 1
S:S:S296 S:S:Y218 5.09 2 No Yes 8 7 2 1
S:S:A298 S:S:Y218 4 2 No Yes 6 7 1 1
S:S:Y218 X:X:?1 22.76 2 Yes Yes 7 0 1 0
S:S:F270 S:S:S296 7.93 2 Yes No 7 8 2 2
S:S:E297 S:S:L322 15.9 0 No No 8 4 1 2
S:S:E297 X:X:?1 6.67 0 No Yes 8 0 1 0
S:S:A298 X:X:?1 9.06 2 No Yes 6 0 1 0
M:M:?1 S:S:S302 5.52 0 No No 0 5 1 2
S:S:I416 X:X:?1 4.11 2 No Yes 4 0 1 0
S:S:I416 X:X:?2 9.85 2 No Yes 4 0 1 2
S:S:S417 X:X:?2 6.91 2 Yes Yes 6 0 2 2
M:M:?1 X:X:?1 3.66 0 No Yes 0 0 1 0
S:S:R66 S:S:S301 2.64 2 Yes No 5 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F668 S:S:Q681 4.68 0 Yes Yes 9 9 2 1
S:S:E837 S:S:F668 13.99 7 Yes Yes 9 9 1 2
S:S:F668 S:S:I841 3.77 0 Yes No 9 9 2 2
S:S:Q681 S:S:W742 4.38 7 Yes Yes 9 9 1 2
S:S:L773 S:S:Q681 3.99 7 Yes Yes 8 9 1 1
S:S:Q681 X:X:?3 14.44 7 Yes Yes 9 0 1 0
S:S:F684 S:S:F688 10.72 7 Yes Yes 8 8 1 2
S:S:F684 S:S:W818 6.01 7 Yes Yes 8 9 1 1
S:S:F684 S:S:I841 17.58 7 Yes No 8 9 1 2
S:S:F684 X:X:?3 16.99 7 Yes Yes 8 0 1 0
S:S:F688 S:S:F814 9.65 0 Yes Yes 8 9 2 2
S:S:Q735 S:S:T780 4.25 0 Yes No 9 7 2 1
S:S:L773 S:S:W742 3.42 7 Yes Yes 8 9 1 2
S:S:E767 S:S:L773 3.98 7 No Yes 7 8 1 1
S:S:E767 X:X:?3 10.27 7 No Yes 7 0 1 0
S:S:G774 S:S:L773 3.42 0 No Yes 4 8 2 1
S:S:I777 S:S:L773 4.28 7 No Yes 8 8 1 1
S:S:L773 X:X:?3 15.01 7 Yes Yes 8 0 1 0
S:S:I777 X:X:?3 11.06 7 No Yes 8 0 1 0
S:S:T780 X:X:?3 11.42 0 No Yes 7 0 1 0
S:S:F814 S:S:W818 12.03 7 Yes Yes 9 9 2 1
S:S:V817 S:S:W818 4.9 0 No Yes 9 9 2 1
S:S:F821 S:S:W818 13.03 7 Yes Yes 9 9 1 1
S:S:A840 S:S:W818 5.19 7 No Yes 9 9 2 1
S:S:W818 X:X:?3 22.06 7 Yes Yes 9 0 1 0
S:S:F821 S:S:Y825 12.38 7 Yes Yes 9 9 1 1
S:S:F821 S:S:V836 5.24 7 Yes No 9 8 1 2
S:S:E837 S:S:F821 10.49 7 Yes Yes 9 9 1 1
S:S:A840 S:S:F821 5.55 7 No Yes 9 9 2 1
S:S:F821 X:X:?3 4.72 7 Yes Yes 9 0 1 0
S:S:V833 S:S:Y825 7.57 0 No Yes 6 9 2 1
S:S:E837 S:S:Y825 6.73 7 Yes Yes 9 9 1 1
S:S:Y825 X:X:?3 18.17 7 Yes Yes 9 0 1 0
S:S:E837 X:X:?3 20.54 7 Yes Yes 9 0 1 0
S:S:E767 S:S:L770 2.65 7 No No 7 3 1 2
S:S:F684 S:S:S664 2.64 7 Yes No 8 6 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:R66 R:R:R69 5.33 1 Yes Yes 5 8 1 2
R:R:R66 R:R:W70 13 1 Yes Yes 5 5 1 2
R:R:R66 W:W:?1 6.12 1 Yes Yes 5 0 1 2
R:R:R66 W:W:?2 18.17 1 Yes Yes 5 0 1 2
L:L:?1 R:R:R66 6.7 0 No Yes 0 5 0 1
R:R:R69 W:W:?2 9.78 1 Yes Yes 8 0 2 2
R:R:W70 W:W:?1 6.55 1 Yes Yes 5 0 2 2
R:R:W70 W:W:?2 9.17 1 Yes Yes 5 0 2 2
R:R:P407 R:R:S303 3.56 1 No No 1 3 2 1
L:L:?1 R:R:S303 5.52 0 No No 0 3 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P39 R:R:W70 5.4 1 Yes Yes 6 5 2 1
R:R:P39 R:R:T145 10.49 1 Yes Yes 6 5 2 1
I:I:?4 R:R:P39 9.06 1 Yes Yes 0 6 2 2
R:R:R66 R:R:R69 5.33 1 Yes Yes 5 8 1 2
R:R:R66 R:R:W70 13 1 Yes Yes 5 5 1 1
R:R:R66 W:W:?1 6.12 1 Yes Yes 5 0 1 0
R:R:R66 W:W:?2 18.17 1 Yes Yes 5 0 1 2
L:L:?1 R:R:R66 6.7 0 No Yes 0 5 2 1
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:R69 R:R:S417 5.27 1 Yes Yes 8 6 2 2
R:R:R69 W:W:?2 9.78 1 Yes Yes 8 0 2 2
R:R:T145 R:R:W70 7.28 1 Yes Yes 5 5 1 1
R:R:I416 R:R:W70 19.97 1 Yes Yes 4 5 1 1
R:R:S417 R:R:W70 3.71 1 Yes Yes 6 5 2 1
R:R:W70 W:W:?1 6.55 1 Yes Yes 5 0 1 0
R:R:W70 W:W:?2 9.17 1 Yes Yes 5 0 1 2
R:R:G146 R:R:T145 3.64 0 No Yes 5 5 2 1
R:R:T145 R:R:Y167 6.24 1 Yes Yes 5 8 1 2
R:R:A168 R:R:T145 5.03 1 No Yes 5 5 1 1
R:R:T145 W:W:?1 5.3 1 Yes Yes 5 0 1 0
I:I:?4 R:R:T145 5.42 1 Yes Yes 0 5 2 1
R:R:S147 R:R:S171 4.89 1 No No 8 7 1 2
R:R:S147 R:R:Y218 5.09 1 No Yes 8 7 1 1
R:R:S147 W:W:?1 6.48 1 No Yes 8 0 1 0
R:R:A168 W:W:?1 4.53 1 No Yes 5 0 1 0
R:R:D190 R:R:S170 10.31 0 No No 8 7 2 1
R:R:S170 W:W:?1 8.64 0 No Yes 7 0 1 0
R:R:D190 R:R:Q193 7.83 0 No Yes 8 9 2 2
R:R:D190 R:R:Y218 5.75 0 No Yes 8 7 2 1
R:R:Q193 R:R:S296 4.33 1 Yes No 9 8 2 2
R:R:E297 R:R:Q193 5.1 1 Yes Yes 8 9 1 2
R:R:G219 R:R:Y218 4.35 0 No Yes 7 7 2 1
R:R:S296 R:R:Y218 6.36 1 No Yes 8 7 2 1
R:R:A298 R:R:Y218 4 1 No Yes 6 7 1 1
R:R:Y218 W:W:?1 22.76 1 Yes Yes 7 0 1 0
R:R:E297 R:R:L322 14.58 1 Yes No 8 4 1 2
R:R:E297 R:R:I416 4.1 1 Yes Yes 8 4 1 1
R:R:E297 W:W:?1 10.48 1 Yes Yes 8 0 1 0
R:R:A298 W:W:?1 9.06 1 No Yes 6 0 1 0
R:R:I416 W:W:?1 4.11 1 Yes Yes 4 0 1 0
R:R:I416 W:W:?2 6.57 1 Yes Yes 4 0 1 2
R:R:S417 W:W:?2 6.91 1 Yes Yes 6 0 2 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F684 R:R:S664 5.28 11 Yes No 8 6 1 2
R:R:F668 R:R:R680 21.38 11 Yes Yes 9 8 2 2
R:R:F668 R:R:Q681 4.68 11 Yes Yes 9 9 2 1
R:R:E837 R:R:F668 13.99 11 No Yes 9 9 1 2
R:R:F668 R:R:I841 3.77 11 Yes No 9 9 2 2
R:R:Q681 R:R:R680 4.67 11 Yes Yes 9 8 1 2
R:R:Q681 R:R:W742 4.38 11 Yes Yes 9 9 1 2
R:R:L773 R:R:Q681 5.32 11 Yes Yes 8 9 2 1
R:R:E837 R:R:Q681 6.37 11 No Yes 9 9 1 1
R:R:Q681 W:W:?3 15.47 11 Yes Yes 9 0 1 0
R:R:F684 R:R:F688 7.5 11 Yes Yes 8 8 1 2
R:R:F684 R:R:W818 7.02 11 Yes Yes 8 9 1 1
R:R:F684 R:R:I841 21.35 11 Yes No 8 9 1 2
R:R:F684 W:W:?3 16.04 11 Yes Yes 8 0 1 0
R:R:F688 R:R:F814 11.79 0 Yes Yes 8 9 2 1
R:R:L773 R:R:W742 5.69 11 Yes Yes 8 9 2 2
R:R:I777 R:R:L773 4.28 0 No Yes 8 8 1 2
R:R:I777 W:W:?3 23.22 0 No Yes 8 0 1 0
R:R:F814 R:R:T780 3.89 11 Yes No 9 7 1 1
R:R:T780 W:W:?3 6.85 11 No Yes 7 0 1 0
R:R:F814 R:R:F815 9.65 11 Yes Yes 9 7 1 2
R:R:F814 R:R:W818 11.02 11 Yes Yes 9 9 1 1
R:R:F814 W:W:?3 3.77 11 Yes Yes 9 0 1 0
R:R:A840 R:R:W818 9.08 0 No Yes 9 9 2 1
R:R:W818 W:W:?3 35.3 11 Yes Yes 9 0 1 0
R:R:I819 R:R:I822 4.42 0 No No 6 7 2 1
R:R:I822 R:R:P823 3.39 0 No Yes 7 9 1 2
R:R:I822 W:W:?3 4.42 0 No Yes 7 0 1 0
R:R:Y825 W:W:?3 15.44 0 No Yes 9 0 1 0
R:R:E837 W:W:?3 16.43 11 No Yes 9 0 1 0
R:R:F684 R:R:G685 3.01 11 Yes No 8 8 1 2
R:R:V833 R:R:Y825 2.52 0 No No 6 9 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9ASB_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.39
Number of Linked Nodes 1587
Number of Links 1959
Number of Hubs 310
Number of Links mediated by Hubs 1133
Number of Communities 49
Number of Nodes involved in Communities 469
Number of Links involved in Communities 692
Path Summary
Number Of Nodes in MetaPath 124
Number Of Links MetaPath 123
Number of Shortest Paths 11301299
Length Of Smallest Path 3
Average Path Length 47.1546
Length of Longest Path 77
Minimum Path Strength 1.155
Average Path Strength 7.55731
Maximum Path Strength 35.96
Minimum Path Correlation 0.7
Average Path Correlation 0.999182
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.27273
Average % Of Corr. Nodes 58.3903
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.5751
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • D2 dopamine receptor binding   • adenylate cyclase inhibitor activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • enzyme inhibitor activity   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • cell division   • leukocyte migration   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • negative regulation of peptide hormone secretion   • negative regulation of establishment of protein localization   • negative regulation of protein secretion   • negative regulation of signaling   • negative regulation of cell communication   • negative regulation of peptide secretion   • negative regulation of cellular process   • negative regulation of protein localization   • negative regulation of insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • ciliary basal body   • amino acid binding   • identical protein binding   • calcium ion binding   • phosphoric ester hydrolase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • phospholipase C activity   • phosphatidylinositol-4,5-bisphosphate phospholipase C activity   • phospholipase activity   • lipase activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • transmembrane transporter binding   • cell adhesion molecule binding   • integrin binding   • protein homodimerization activity   • protein dimerization activity   • kinase binding   • protein kinase binding   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of monoatomic ion transport   • metal ion transport   • calcium ion transport   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • tube development   • branching morphogenesis of an epithelial tube   • morphogenesis of an epithelium   • tissue morphogenesis   • tube morphogenesis   • morphogenesis of a branching structure   • epithelial tube morphogenesis   • morphogenesis of a branching epithelium   • regulation of tube diameter   • regulation of tube size   • regulation of system process   • positive regulation of vasoconstriction   • circulatory system process   • regulation of blood circulation   • vascular process in circulatory system   • regulation of vasoconstriction   • blood vessel diameter maintenance   • vasoconstriction   • blood circulation   • regulation of anatomical structure size   • monoatomic ion transmembrane transport   • chloride transport   • transmembrane transport   • chloride transmembrane transport   • monoatomic anion transport   • monoatomic anion transmembrane transport   • inorganic anion transport   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of gene expression   • regulation of macromolecule biosynthetic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • response to ischemia   • response to decreased oxygen levels   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • response to hypoxia   • response to oxygen levels   • response to abiotic stimulus   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • calcium ion homeostasis   • cellular homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • organic acid transport   • bile acid secretion   • organic anion transport   • monocarboxylic acid transport   • carboxylic acid transport   • acid secretion   • response to peptide   • cellular response to peptide   • behavior   • chemosensory behavior   • JNK cascade   • MAPK cascade   • cellular response to low-density lipoprotein particle stimulus   • response to lipoprotein particle   • cellular response to lipoprotein particle stimulus   • regulation of calcium ion import   • positive regulation of calcium ion transport   • positive regulation of calcium ion import   • positive regulation of transport   • positive regulation of monoatomic ion transport   • calcium ion import   • ossification   • connective tissue development   • adipose tissue development   • fat pad development   • response to fibroblast growth factor   • response to growth factor   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • cellular response to glucose stimulus   • intracellular glucose homeostasis   • response to hexose   • cellular response to carbohydrate stimulus   • response to monosaccharide   • response to carbohydrate   • response to glucose   • glucose homeostasis   • carbohydrate homeostasis   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • response to nutrient levels   • response to nutrient   • response to vitamin   • cellular response to vitamin D   • cellular response to nutrient levels   • response to vitamin D   • cellular response to vitamin   • cellular response to nutrient   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • vasodilation   • positive chemotaxis   • chemotaxis   • positive regulation of locomotion   • positive regulation of positive chemotaxis   • regulation of chemotaxis   • positive regulation of chemotaxis   • regulation of positive chemotaxis   • positive regulation of response to external stimulus   • taxis   • regulation of locomotion   • locomotion   • response to hepatocyte growth factor   • cellular response to growth factor stimulus   • cellular response to hepatocyte growth factor stimulus   • positive regulation of establishment of protein localization   • positive regulation of insulin secretion   • positive regulation of peptide hormone secretion   • positive regulation of secretion by cell   • positive regulation of protein transport   • positive regulation of hormone secretion   • positive regulation of secretion   • positive regulation of peptide secretion   • positive regulation of protein secretion   • detection of stimulus   • response to metal ion   • detection of chemical stimulus   • detection of calcium ion   • response to calcium ion   • presynapse   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse   • somatodendritic compartment   • cell body   • neuronal cell body   • apical part of cell   • apical plasma membrane   • cell surface   • axon   • axon terminus   • distal axon   • neuron projection terminus
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Type 1 solute binding protein-like   • TNF receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Type 1 solute binding protein-like   • TNF receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8 H:H:?9 H:H:?1 H:H:?2 H:H:?3
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylglucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodeTCR
PDB ResiduesX:X:?1 W:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeTCR
NameCYCLOMETHYLTRYPTOPHAN
Synonyms
Identifier
FormulaC12 H12 N2 O2
Molecular Weight216.236
SMILES
PubChem449440
Formal Charge0
Total Atoms28
Total Chiral Atoms1
Total Bonds30
Total Aromatic Bonds10

CodePO4
PDB ResiduesX:X:?2 W:W:?2
Environment DetailsOpen EMBL-EBI Page
CodePO4
NamePhosphate ion
Synonyms
  • Orthophosphate
  • Phosphate ion
  • Phosphate
Identifier
FormulaO4 P
Molecular Weight94.971
SMILES
PubChem1061
Formal Charge-3
Total Atoms5
Total Chiral Atoms0
Total Bonds4
Total Aromatic Bonds0

CodeCA
PDB ResiduesI:I:?1 M:M:?1 I:I:?2 I:I:?3 I:I:?4 L:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeCA
NameCALCIUM ION
Synonyms
Identifier
FormulaCa
Molecular Weight40.078
SMILES
PubChem
Formal Charge2
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

Code9IG
PDB ResiduesX:X:?3 W:W:?3
Environment DetailsOpen EMBL-EBI Page
Code9IG
Name3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine
Synonyms
Identifier
FormulaC18 H22 Cl N O
Molecular Weight303.826
SMILES
PubChem158797
Formal Charge0
Total Atoms43
Total Chiral Atoms1
Total Bonds44
Total Aromatic Bonds12

PDBsumOpen PDBsum Page
ChainS
ProteinReceptor
UniProtP41180
Sequence
>9ASB_nogp_Chain_S
GPDQRAQKK GDIILGGLF PIHFGVAAK DQDLKSRPE SVECIRYNF 
RGFRWLQAM IFAIEEINS SPALLPNLT LGYRIFDTC NTVSKALEA 
TLSFVAQNK IDSLNEHIP STIAVVGAT GSGVSTAVA NLLGLFYIP 
QVSYASSSR LLSNKNQFK SFLRTIPND EHQATAMAD IIEYFRWNW 
VGTIAADDD YGRPGIEKF REEAEERDI CIDFSELIS QYSDEEEIQ 
HVVEVIQNS TAKVIVVFS SGPDLEPLI KEIVRRNIT GKIWLASEA 
WASSSLIAM PQYFHVVGG TIGFALKAG QIPGFREFL KKVHPRKSV 
HNGFAKEFW EETFNCHLR PLCTGDENI SSVETPYID YTHLRISYN 
VYLAVYSIA HALQDIYTC LPGRGLFTN GSCADIKKV EAWQVLKHL 
RHLNFTNNM GEQVTFDEC GDLVGNYSI INWHLSPED GSIVFKEVG 
YYNVYAKKG ERLFINEEK ILWSGFSRE VPFSNCSRD CLAGTRKGI 
IEGEPTCCF ECVECPDGE YSDETDASA CNKCPDDFW SNENHTSCI 
AKEIEFLSW TEPFGIALT LFAVLGIFL TAFVLGVFI KFRNTPIVK 
ATNRELSYL LLFSLLCCF SSSLFFIGE PQDWTCRLR QPAFGISFV 
LCISCILVK TNRVLLVFE AWGLNLQFL LVFLCTFMQ IVICVIWLY 
TAPPSSYRN QELEDEIIF ITCHEGSLM ALGFLIGYT CLLAAICFF 
FAFKSRKLP ENFNEAKFI TFSMLIFFI VWISFIPAY ASTYGKFVS 
AVEVIAILA ASFGLLACI FFNKIYIIL FKPSRNTIE EVR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP41180
Sequence
>9ASB_nogp_Chain_R
GPDQRAQKK GDIILGGLF PIHFGVAAK DQDLKSRPE SVECIRYNF 
RGFRWLQAM IFAIEEINS SPALLPNLT LGYRIFDTC NTVSKALEA 
TLSFVAQNK IDSLNSEHI PSTIAVVGA TGSGVSTAV ANLLGLFYI 
PQVSYASSS RLLSNKNQF KSFLRTIPN DEHQATAMA DIIEYFRWN 
WVGTIAADD DYGRPGIEK FREEAEERD ICIDFSELI SQYSDEEEI 
QHVVEVIQN STAKVIVVF SSGPDLEPL IKEIVRRNI TGKIWLASE 
AWASSSLIA MPQYFHVVG GTIGFALKA GQIPGFREF LKKVHPRKS 
VHNGFAKEF WEETFNCHL RPLCTGDEN ISSVETPYI DYTHLRISY 
NVYLAVYSI AHALQDIYT CLPGRGLFT NGSCADIKK VEAWQVLKH 
LRHLNFTNN MGEQVTFDE CGDLVGNYS IINWHLSPE DGSIVFKEV 
GYYNVYAKK GERLFINEE KILWSGFSR EVPFSNCSR DCLAGTRKG 
IIEGEPTCC FECVECPDG EYSDETDAS ACNKCPDDF WSNENHTSC 
IAKEIEFLS WTEPFGIAL TLFAVLGIF LTAFVLGVF IKFRNTPIV 
KATNRELSY LLLFSLLCC FSSSLFFIG EPQDWTCRL RQPAFGISF 
VLCISCILV KTNRVLLVF EAKIPTSFH RKWWGLNLQ FLLVFLCTF 
MQIVICVIW LYTAPPSSY RNQELEDEI IFITCHEGS LMALGFLIG 
YTCLLAAIC FFFAFKSRK LPENFNEAK FITFSMLIF FIVWISFIP 
AYASTYGKF VSAVEVIAI LAASFGLLA CIFFNKIYI ILFKPSRN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WPGCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca-2.72023-11-22doi.org/10.1038/s41422-023-00892-2
8WPUCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(NtGi2L-Gs-CtGq)/β1/γ23.12023-11-22doi.org/10.1038/s41422-023-00892-2
8WPU (No Gprot) CIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca3.12023-11-22doi.org/10.1038/s41422-023-00892-2
7DTUCIonCalcium SensingCaSHomo sapiens-Tryptophan-4.42021-03-10doi.org/10.1038/s41422-021-00474-0
7M3JCIonCalcium SensingCaSHomo sapiens-NPS-2143; PO4-4.12021-06-30doi.org/10.1038/s41586-021-03691-0
7SINCIonCalcium SensingCaSHomo sapiens-NPS-2143-5.92022-01-19doi.org/10.1073/pnas.2115849118
9C1PCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan; '6218; PO4-2.82024-10-02doi.org/10.1126/science.ado1868
7DTVCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan-3.52021-03-10doi.org/10.1038/s41422-021-00474-0
7M3ECIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; NPS-2143-3.22021-06-30doi.org/10.1038/s41586-021-03691-0
7DD5CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; NPS-2143-3.22021-06-16doi.org/10.1126/sciadv.abg1483
7M3GCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4-2.52021-06-30doi.org/10.1038/s41586-021-03691-0
7DD7CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; Evocalcet-3.22021-06-16doi.org/10.1126/sciadv.abg1483
8SZFCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-2.82024-02-07doi.org/10.1038/s41586-024-07055-2
8SZGCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Sperminechim(NtGi1-Gq)/β1/γ23.62024-02-07doi.org/10.1038/s41586-024-07055-2
8SZG (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine3.62024-02-07doi.org/10.1038/s41586-024-07055-2
8SZHCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; SpermineGi1/β1/γ23.12024-02-07doi.org/10.1038/s41586-024-07055-2
8SZH (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine3.12024-02-07doi.org/10.1038/s41586-024-07055-2
7M3FCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4-2.82021-06-30doi.org/10.1038/s41586-021-03691-0
8SZICIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4Gi3/β1/γ23.52024-02-07doi.org/10.1038/s41586-024-07055-2
8SZI (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO43.52024-02-07doi.org/10.1038/s41586-024-07055-2
9C2FCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Tryptophan; '54149; PO4-2.82024-10-02doi.org/10.1126/science.ado1868
7DD6CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan-3.22021-06-16doi.org/10.1126/sciadv.abg1483
7SIMCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-2.72022-01-19doi.org/10.1073/pnas.2115849118
7E6TCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-32021-09-22doi.org/10.7554/eLife.68578
9ASBCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.42024-04-17doi.org/10.1038/s41586-024-07331-1
9ASB (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.42024-04-17doi.org/10.1038/s41586-024-07331-1
9AVGCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs)/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AVG (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AVLCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4Gi3/β2/γ23.82024-04-17doi.org/10.1038/s41586-024-07331-1
9AVL (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.82024-04-17doi.org/10.1038/s41586-024-07331-1
9AXFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.52024-04-17doi.org/10.1038/s41586-024-07331-1
9AXF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.52024-04-17doi.org/10.1038/s41586-024-07331-1
9AYFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4Gi1/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AYF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-17doi.org/10.1038/s41586-024-07331-1
7SILCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-2.72022-01-19doi.org/10.1073/pnas.2115849118
7DTTCIonCalcium SensingCaSHomo sapiensCaCa-3.82021-03-10doi.org/10.1038/s41422-021-00474-0
7DTWCIonCalcium SensingCaSHomo sapiens---4.52021-03-10doi.org/10.1038/s41422-021-00474-0
7E6UCIonCalcium SensingCaSHomo sapiens---62021-09-22doi.org/10.7554/eLife.68578




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9ASB_nogp.zip



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You can also  read or  download a guide explaining the meaning of all files and numerical data.