psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	I:I:?1	R:R:G557	3.14	No	No	24	0	6
2	I:I:?1	S:S:D234	7.49	No	No	24	0	5
3	I:I:?2	R:R:D234	7.49	No	No	25	0	5
4	I:I:?2	S:S:G557	3.14	No	No	25	0	6
5	R:R:R25	R:R:Y20	10.29	No	Yes	0	4	2
6	R:R:R96	R:R:Y20	6.17	Yes	Yes	8	4	2
7	R:R:S113	R:R:Y20	8.9	No	Yes	8	4	2
8	R:R:I135	R:R:Y20	4.84	Yes	Yes	0	4	2
9	R:R:G21	R:R:P22	4.06	No	No	8	3	5
10	R:R:E109	R:R:G21	4.91	Yes	No	8	5	3
11	R:R:G21	S:S:L123	3.42	No	No	8	3	5
12	R:R:F98	R:R:P22	8.67	Yes	No	8	4	5
13	R:R:E109	R:R:P22	3.14	Yes	No	8	5	5
14	R:R:F347	R:R:Q24	12.88	Yes	No	0	5	5
15	R:R:E350	R:R:Q24	6.37	No	No	0	5	5
16	R:R:Q27	R:R:R25	10.51	No	No	0	4	4
17	R:R:F98	R:R:R25	13.9	Yes	No	0	4	4
18	R:R:A26	R:R:N345	4.69	No	Yes	0	6	8
19	R:R:Q27	R:R:R96	7.01	No	Yes	0	4	4
20	R:R:E79	R:R:K28	4.05	No	No	0	7	5
21	R:R:K28	R:R:Y95	14.33	No	Yes	2	5	8
22	R:R:H344	R:R:K28	20.96	No	No	2	3	5
23	R:R:G30	R:R:K29	3.49	No	No	0	9	3
24	R:R:D31	R:R:L91	4.07	No	No	0	8	6
25	R:R:D31	R:R:T92	11.56	No	No	0	8	7
26	R:R:I32	R:R:L93	4.28	No	No	0	6	9
27	R:R:I139	R:R:I32	5.89	No	No	0	5	6
28	R:R:I32	R:R:L431	4.28	No	No	0	6	8
29	R:R:I33	R:R:R96	3.76	No	Yes	0	5	4
30	R:R:I33	R:R:P136	3.39	No	No	0	5	4
31	R:R:I427	R:R:L34	7.14	No	No	0	5	7
32	R:R:F114	R:R:G35	4.52	Yes	No	8	5	8
33	R:R:G35	R:R:V141	3.68	No	No	8	8	7
34	R:R:G36	R:R:M74	3.49	No	Yes	2	7	8
35	R:R:G36	R:R:I97	3.53	No	Yes	2	7	8
36	R:R:L37	R:R:T100	4.42	No	No	0	6	7
37	R:R:F114	R:R:L37	4.87	Yes	No	0	5	6
38	R:R:L37	R:R:V153	4.47	No	No	0	6	6
39	R:R:F38	R:R:L71	3.65	Yes	No	0	7	4
40	R:R:F38	R:R:M74	7.46	Yes	Yes	2	7	8
41	R:R:F38	R:R:Y167	13.41	Yes	Yes	2	7	8
42	R:R:F38	R:R:V420	5.24	Yes	No	2	7	7
43	R:R:N64	R:R:P39	3.26	Yes	Yes	0	4	6
44	R:R:P39	R:R:W70	5.4	Yes	Yes	2	6	5
45	R:R:N102	R:R:P39	4.89	No	Yes	0	3	6
46	R:R:P39	R:R:T145	8.74	Yes	Yes	2	6	5
47	R:R:H41	R:R:I40	6.63	Yes	Yes	2	7	5
48	R:R:I40	R:R:Y63	6.04	Yes	Yes	2	5	5
49	R:R:D99	R:R:I40	11.2	Yes	Yes	2	9	5
50	R:R:F347	R:R:I40	3.77	Yes	Yes	2	5	5
51	R:R:C60	R:R:H41	13.27	No	Yes	2	7	7
52	R:R:H41	R:R:Y63	5.44	Yes	Yes	2	7	5
53	R:R:D99	R:R:H41	5.04	Yes	Yes	2	9	7
54	R:R:C101	R:R:H41	5.9	Yes	Yes	2	8	7
55	R:R:E350	R:R:H41	8.62	No	Yes	2	5	7
56	R:R:F42	R:R:R62	5.34	Yes	No	0	3	4
57	R:R:F42	R:R:N64	20.54	Yes	Yes	0	3	4
58	R:R:F42	R:R:P274	4.33	Yes	Yes	26	3	3
59	R:R:F42	R:R:L304	15.83	Yes	No	26	3	2
60	R:R:V44	R:R:V58	6.41	No	No	0	2	1
61	R:R:T103	R:R:V44	6.35	No	No	0	4	2
62	R:R:A45	R:R:K47	3.21	No	No	0	1	2
63	R:R:K47	R:R:Q49	12.2	No	No	0	2	1
64	R:R:E59	R:R:K47	13.5	No	No	0	1	2
65	R:R:D50	R:R:K52	13.83	No	No	0	3	3
66	R:R:L51	R:R:P55	3.28	Yes	No	0	6	6
67	R:R:L51	S:S:L461	4.15	Yes	No	0	6	7
68	R:R:L51	S:S:K462	8.46	Yes	Yes	0	6	4
69	R:R:L51	S:S:R465	9.72	Yes	No	0	6	5
70	R:R:K52	S:S:T445	4.5	No	Yes	0	3	1
71	R:R:R54	S:S:E456	5.82	No	Yes	10	2	5
72	R:R:R54	S:S:W458	14.99	No	Yes	10	2	4
73	R:R:P55	S:S:Y161	9.74	No	No	0	6	4
74	R:R:P55	S:S:W458	13.51	No	Yes	0	6	4
75	R:R:K106	R:R:V58	3.04	Yes	No	0	4	1
76	R:R:C101	R:R:C60	7.28	Yes	No	2	8	7
77	R:R:C60	R:R:K106	3.23	No	Yes	2	7	4
78	R:R:E277	R:R:R62	3.49	Yes	No	0	2	4
79	R:R:F65	R:R:Y63	8.25	Yes	Yes	2	2	5
80	R:R:F68	R:R:Y63	6.19	Yes	Yes	2	7	5
81	R:R:E350	R:R:Y63	8.98	No	Yes	2	5	5
82	R:R:F351	R:R:Y63	6.19	Yes	Yes	2	6	5
83	R:R:E354	R:R:Y63	14.59	No	Yes	0	4	5
84	R:R:N64	R:R:R66	3.62	Yes	Yes	0	4	5
85	R:R:G67	R:R:N64	5.09	No	Yes	0	4	4
86	R:R:F351	R:R:F65	4.29	Yes	Yes	2	6	2
87	R:R:F65	R:R:T406	15.56	Yes	No	0	2	4
88	R:R:F65	R:R:P407	7.22	Yes	No	0	2	1
89	R:R:R66	R:R:R69	5.33	Yes	Yes	2	5	8
90	R:R:R66	R:R:W70	7	Yes	Yes	2	5	5
91	R:R:R66	W:W:W1	4	Yes	Yes	2	5	0
92	R:R:R66	W:W:?2	26.56	Yes	Yes	2	5	0
93	R:R:G67	R:R:W70	5.63	No	Yes	0	4	5
94	R:R:F68	R:R:Q72	11.71	Yes	Yes	2	7	7
95	R:R:F68	R:R:N345	6.04	Yes	Yes	2	7	8
96	R:R:F351	R:R:F68	11.79	Yes	Yes	2	6	7
97	R:R:F68	R:R:Y408	8.25	Yes	Yes	2	7	3
98	R:R:L334	R:R:R69	4.86	Yes	Yes	2	6	8
99	R:R:R69	R:R:Y411	11.32	Yes	Yes	2	8	5
100	R:R:R69	R:R:S417	6.59	Yes	Yes	2	8	6
101	R:R:R69	W:W:?2	16.77	Yes	Yes	2	8	0
102	R:R:T145	R:R:W70	7.28	Yes	Yes	2	5	5
103	R:R:W70	R:R:Y167	3.86	Yes	Yes	2	5	8
104	R:R:I416	R:R:W70	12.92	Yes	Yes	2	4	5
105	R:R:S417	R:R:W70	3.71	Yes	Yes	2	6	5
106	R:R:W70	W:W:W1	4.69	Yes	Yes	2	5	0
107	R:R:W70	W:W:?2	14.42	Yes	Yes	2	5	0
108	R:R:I97	R:R:L71	7.14	Yes	No	0	8	4
109	R:R:L71	R:R:N345	4.12	No	Yes	0	4	8
110	R:R:F333	R:R:Q72	8.2	No	Yes	0	7	7
111	R:R:N345	R:R:Q72	3.96	Yes	Yes	2	8	7
112	R:R:Q72	R:R:Y408	6.76	Yes	Yes	2	7	3
113	R:R:A73	R:R:F330	4.16	No	Yes	0	7	8
114	R:R:A73	R:R:V420	3.39	No	No	0	7	7
115	R:R:I97	R:R:M74	7.29	Yes	Yes	2	8	8
116	R:R:M74	R:R:V142	4.56	Yes	No	0	8	7
117	R:R:M74	R:R:V424	3.04	Yes	No	0	8	8
118	R:R:I75	R:R:Y95	10.88	No	Yes	0	4	8
119	R:R:F333	R:R:I75	5.02	No	No	0	7	4
120	R:R:E80	R:R:F76	5.83	No	No	0	8	7
121	R:R:F330	R:R:F76	6.43	Yes	No	0	8	7
122	R:R:F333	R:R:F76	12.86	No	No	0	7	7
123	R:R:A77	R:R:Y421	4	No	Yes	0	8	8
124	R:R:A77	R:R:V424	5.09	No	No	0	8	8
125	R:R:I78	R:R:Y95	7.25	No	Yes	0	6	8
126	R:R:E80	R:R:Y421	10.1	No	Yes	2	8	8
127	R:R:E80	R:R:Y425	10.1	No	No	2	8	8
128	R:R:I81	R:R:L93	5.71	No	No	0	9	9
129	R:R:I81	R:R:Y425	4.84	No	No	0	9	8
130	R:R:A428	R:R:I81	4.87	No	No	0	9	9
131	R:R:N82	R:R:T92	4.39	No	No	0	9	7
132	R:R:L93	R:R:N82	5.49	No	No	0	9	9
133	R:R:P85	R:R:S84	3.56	No	No	0	3	6
134	R:R:H429	R:R:L87	10.29	No	No	0	6	6
135	R:R:L88	R:R:L91	9.69	No	No	0	9	6
136	R:R:L431	R:R:L88	4.15	No	No	0	8	9
137	R:R:P89	R:R:Y435	8.34	No	Yes	0	8	3
138	R:R:P89	W:W:?3	9.06	No	No	0	8	0
139	R:R:I97	R:R:Y95	8.46	Yes	Yes	2	8	8
140	R:R:H344	R:R:Y95	3.27	No	Yes	2	3	8
141	R:R:F98	R:R:R96	6.41	Yes	Yes	8	4	4
142	R:R:R96	R:R:S113	5.27	Yes	No	8	4	4
143	R:R:F114	R:R:R96	4.28	Yes	Yes	8	5	4
144	R:R:A110	R:R:F98	5.55	No	Yes	0	5	4
145	R:R:F98	R:R:S113	5.28	Yes	No	8	4	4
146	R:R:F114	R:R:F98	6.43	Yes	Yes	8	5	4
147	R:R:C101	R:R:D99	6.22	Yes	Yes	2	8	9
148	R:R:D99	R:R:F347	4.78	Yes	Yes	2	9	5
149	R:R:A107	R:R:T100	3.36	No	No	0	7	7
150	R:R:C101	R:R:K106	3.23	Yes	Yes	2	8	4
151	R:R:S105	R:R:T103	3.2	No	No	0	4	4
152	R:R:A152	R:R:V104	3.39	No	No	3	5	4
153	R:R:V104	S:S:N155	5.91	No	Yes	3	4	5
154	R:R:V104	S:S:Q179	7.16	No	No	3	4	5
155	R:R:L108	S:S:L159	4.15	No	No	0	4	5
156	R:R:E109	S:S:L123	6.63	Yes	No	8	5	5
157	R:R:T111	R:R:V153	7.93	No	No	0	7	6
158	R:R:L156	R:R:T111	5.9	No	No	0	5	7
159	R:R:L112	S:S:L156	4.15	No	No	0	5	5
160	R:R:F114	R:R:T138	5.19	Yes	No	0	5	6
161	R:R:F114	R:R:V141	5.24	Yes	No	8	5	7
162	R:R:F160	R:R:V115	7.87	No	No	0	7	5
163	R:R:I120	R:R:Q117	4.12	No	Yes	0	3	6
164	R:R:D121	R:R:Q117	10.44	No	Yes	0	3	6
165	R:R:I135	R:R:Q117	12.35	Yes	Yes	0	4	6
166	R:R:Q117	R:R:S137	4.33	Yes	No	0	6	4
167	R:R:N118	R:R:S137	5.96	No	No	0	4	4
168	R:R:F160	R:R:N118	7.25	No	No	0	7	4
169	R:R:I162	R:R:N118	4.25	Yes	No	0	6	4
170	R:R:K119	R:R:L123	8.46	No	Yes	0	3	5
171	R:R:K119	S:S:L112	5.64	No	No	0	3	5
172	R:R:I120	R:R:L125	4.28	No	No	0	3	4
173	R:R:L123	R:R:L125	4.15	Yes	No	0	5	4
174	R:R:L123	S:S:E109	3.98	Yes	No	0	5	5
175	R:R:C131	R:R:D126	4.67	No	No	0	3	3
176	R:R:I135	R:R:S132	3.1	Yes	No	0	4	4
177	R:R:I139	R:R:V460	4.61	No	No	0	5	7
178	R:R:A140	R:R:P163	5.61	No	Yes	0	6	8
179	R:R:A140	R:R:I427	4.87	No	No	0	6	5
180	R:R:L157	R:R:V141	5.96	No	No	0	7	7
181	R:R:G143	R:R:Q164	4.93	No	Yes	0	9	8
182	R:R:G143	R:R:S166	3.71	No	Yes	0	9	9
183	R:R:A144	R:R:V149	5.09	No	No	0	6	4
184	R:R:A144	R:R:S150	3.42	No	No	0	6	8
185	R:R:G146	R:R:T145	3.64	No	Yes	0	5	5
186	R:R:T145	R:R:Y167	7.49	Yes	Yes	2	5	8
187	R:R:A168	R:R:T145	5.03	No	Yes	2	5	5
188	R:R:T145	W:W:W1	6.06	Yes	Yes	2	5	0
189	R:R:S147	R:R:S171	4.89	No	No	0	8	7
190	R:R:S147	R:R:Y218	5.09	No	Yes	0	8	7
191	R:R:S150	R:R:S166	3.26	No	Yes	5	8	9
192	R:R:S150	R:R:S169	6.52	No	No	5	8	8
193	R:R:L174	R:R:T151	4.42	Yes	No	5	7	5
194	R:R:F180	R:R:T151	6.49	Yes	No	5	5	5
195	R:R:D217	R:R:T151	4.34	No	No	0	6	5
196	R:R:A152	S:S:N155	3.13	No	Yes	3	5	5
197	R:R:Q164	R:R:V153	4.3	Yes	No	0	8	6
198	R:R:N155	R:R:Q179	5.28	Yes	Yes	5	5	5
199	R:R:F180	R:R:N155	4.83	Yes	Yes	5	5	5
200	R:R:N155	S:S:V104	8.87	Yes	No	5	5	4
201	R:R:N155	S:S:A152	3.13	Yes	No	0	5	5
202	R:R:L156	S:S:L112	4.15	No	No	0	5	5
203	R:R:I162	R:R:L157	4.28	Yes	No	0	6	7
204	R:R:L157	R:R:Q164	5.32	No	Yes	0	7	8
205	R:R:G158	R:R:S182	3.71	No	No	0	6	7
206	R:R:F160	R:R:L159	3.65	No	No	0	7	5
207	R:R:K181	R:R:Y161	7.17	No	No	0	7	4
208	R:R:Y161	S:S:P55	16.69	No	No	0	4	6
209	R:R:I162	R:R:P163	3.39	Yes	Yes	0	6	8
210	R:R:A457	R:R:I162	4.87	No	Yes	0	4	6
211	R:R:P163	R:R:V460	3.53	Yes	No	0	8	7
212	R:R:L461	R:R:P163	6.57	No	Yes	0	7	8
213	R:R:L464	R:R:P163	3.28	Yes	Yes	0	7	8
214	R:R:F183	R:R:Q164	10.54	Yes	Yes	0	8	8
215	R:R:A423	R:R:V165	3.39	No	No	0	9	6
216	R:R:I427	R:R:V165	4.61	No	No	0	5	6
217	R:R:S166	R:R:S169	6.52	Yes	No	5	9	8
218	R:R:F183	R:R:S166	3.96	Yes	Yes	5	8	9
219	R:R:I416	R:R:Y167	4.84	Yes	Yes	2	4	8
220	R:R:V420	R:R:Y167	8.83	No	Yes	2	7	8
221	R:R:A168	W:W:W1	5.19	No	Yes	2	5	0
222	R:R:I187	R:R:S170	4.64	Yes	No	0	6	7
223	R:R:D190	R:R:S170	7.36	No	No	0	8	7
224	R:R:L173	R:R:S171	4.5	Yes	No	27	5	7
225	R:R:P221	R:R:S171	3.56	No	No	27	3	7
226	R:R:L173	R:R:R172	6.07	Yes	No	0	5	4
227	R:R:E191	R:R:R172	8.14	No	No	0	3	4
228	R:R:R172	S:S:D215	10.72	No	No	0	4	6
229	R:R:D217	R:R:L173	5.43	No	Yes	0	6	5
230	R:R:L173	R:R:P221	8.21	Yes	No	27	5	3
231	R:R:L173	S:S:R220	8.5	Yes	No	0	5	6
232	R:R:F180	R:R:L174	3.65	Yes	Yes	5	5	7
233	R:R:F183	R:R:L174	18.27	Yes	Yes	5	8	7
234	R:R:L174	R:R:R185	4.86	Yes	Yes	5	7	9
235	R:R:R185	R:R:S175	5.27	Yes	No	5	9	8
236	R:R:C482	R:R:S175	6.89	No	No	5	7	8
237	R:R:D484	R:R:S175	5.89	Yes	No	5	8	8
238	R:R:N176	R:R:N178	8.17	No	No	0	6	3
239	R:R:N176	R:R:Q179	6.6	No	Yes	0	6	5
240	R:R:F183	R:R:K177	3.72	Yes	No	0	8	7
241	R:R:N178	S:S:Y246	15.12	No	No	0	3	3
242	R:R:F180	R:R:Q179	10.54	Yes	Yes	5	5	5
243	R:R:Q179	S:S:V104	5.73	Yes	No	5	5	4
244	R:R:L461	R:R:S182	4.5	No	No	0	7	7
245	R:R:F183	R:R:R185	6.41	Yes	Yes	5	8	9
246	R:R:L184	R:R:L464	4.15	No	Yes	0	6	7
247	R:R:N189	R:R:R185	6.03	No	Yes	5	8	9
248	R:R:D484	R:R:R185	5.96	Yes	Yes	5	8	9
249	R:R:L422	R:R:T186	4.42	No	No	0	8	8
250	R:R:I187	R:R:P188	3.39	Yes	No	0	6	8
251	R:R:I187	R:R:L322	5.71	Yes	No	28	6	4
252	R:R:I187	R:R:N419	5.66	Yes	No	28	6	7
253	R:R:E191	R:R:N189	7.89	No	No	0	3	8
254	R:R:D484	R:R:N189	4.04	Yes	No	5	8	8
255	R:R:D190	R:R:Y218	9.2	No	Yes	0	8	7
256	R:R:D190	R:R:F270	3.58	No	Yes	0	8	7
257	R:R:E191	R:R:K225	14.85	No	Yes	0	3	3
258	R:R:H192	R:R:Y489	3.27	No	Yes	0	4	8
259	R:R:H192	R:R:V513	15.22	No	No	0	4	3
260	R:R:E297	R:R:Q193	5.1	No	No	0	8	9
261	R:R:F320	R:R:Q193	7.03	Yes	No	29	6	9
262	R:R:Q193	R:R:Y489	4.51	No	Yes	29	9	8
263	R:R:A194	R:R:K225	3.21	No	Yes	0	7	3
264	R:R:E229	R:R:T195	12.7	Yes	No	0	5	4
265	R:R:A196	R:R:F320	4.16	No	Yes	0	8	6
266	R:R:A196	R:R:Y511	10.68	No	Yes	0	8	5
267	R:R:M197	R:R:V268	4.56	No	Yes	0	7	6
268	R:R:F270	R:R:M197	7.46	Yes	No	0	7	7
269	R:R:F320	R:R:M197	6.22	Yes	No	0	6	7
270	R:R:A198	R:R:R233	5.53	No	Yes	0	7	4
271	R:R:D199	R:R:R233	10.72	No	Yes	0	7	4
272	R:R:D199	R:R:Y511	4.6	No	Yes	0	7	5
273	R:R:D199	R:R:L521	4.07	No	No	0	7	5
274	R:R:I200	R:R:I491	5.89	No	Yes	0	8	8
275	R:R:I201	R:R:V209	6.14	No	Yes	6	6	8
276	R:R:I201	R:R:I235	5.89	No	Yes	6	6	7
277	R:R:E202	R:R:R233	9.3	No	Yes	0	5	4
278	R:R:F204	R:R:Y203	9.28	Yes	No	6	7	5
279	R:R:L521	R:R:Y203	3.52	No	No	6	5	5
280	R:R:I523	R:R:Y203	7.25	Yes	No	6	6	5
281	R:R:F204	R:R:W206	13.03	Yes	Yes	6	7	9
282	R:R:F204	R:R:I523	3.77	Yes	Yes	6	7	6
283	R:R:E525	R:R:F204	3.5	No	Yes	6	4	7
284	R:R:F204	R:R:W530	12.03	Yes	Yes	6	7	8
285	R:R:V266	R:R:W206	7.36	Yes	Yes	6	7	9
286	R:R:W206	R:R:W530	3.75	Yes	Yes	6	9	8
287	R:R:S540	R:R:W206	11.12	No	Yes	6	9	9
288	R:R:N207	R:R:N541	12.26	No	No	0	6	5
289	R:R:C561	R:R:N207	7.87	No	No	0	9	6
290	R:R:D238	R:R:W208	20.1	Yes	Yes	9	8	9
291	R:R:A264	R:R:W208	3.89	No	Yes	9	7	9
292	R:R:C542	R:R:W208	20.89	No	Yes	9	9	9
293	R:R:P559	R:R:W208	8.11	No	Yes	0	6	9
294	R:R:C562	R:R:W208	7.84	No	Yes	9	9	9
295	R:R:G210	R:R:V209	3.68	No	Yes	0	8	8
296	R:R:I235	R:R:V209	3.07	Yes	Yes	6	7	8
297	R:R:I237	R:R:V209	3.07	No	Yes	0	6	8
298	R:R:V209	R:R:V266	3.21	Yes	Yes	6	8	7
299	R:R:F239	R:R:G210	9.03	Yes	No	0	6	8
300	R:R:I223	R:R:T211	6.08	No	Yes	0	5	5
301	R:R:I237	R:R:T211	9.12	No	Yes	0	6	5
302	R:R:S240	R:R:T211	6.4	No	Yes	0	4	5
303	R:R:T211	R:R:V268	3.17	Yes	Yes	0	5	6
304	R:R:F239	R:R:I212	3.77	Yes	No	0	6	6
305	R:R:I212	R:R:I243	4.42	No	Yes	0	6	5
306	R:R:A213	R:R:I223	4.87	No	No	0	4	5
307	R:R:A214	R:R:D216	3.09	No	No	0	5	6
308	R:R:A214	R:R:S271	3.42	No	No	0	5	4
309	R:R:A214	R:R:D275	4.63	No	No	0	5	5
310	R:R:D215	R:R:R220	7.15	Yes	No	0	6	6
311	R:R:D215	R:R:L242	8.14	Yes	No	0	6	4
312	R:R:D215	S:S:R172	10.72	Yes	No	0	6	4
313	R:R:D216	R:R:Y218	3.45	No	Yes	0	6	7
314	R:R:D217	R:R:R220	3.57	No	No	0	6	6
315	R:R:G219	R:R:Y218	4.35	No	Yes	0	7	7
316	R:R:S296	R:R:Y218	6.36	No	Yes	0	8	7
317	R:R:A298	R:R:Y218	4	No	Yes	0	6	7
318	R:R:R220	S:S:L173	10.93	No	Yes	0	6	5
319	R:R:F270	R:R:G222	4.52	Yes	No	0	7	7
320	R:R:F270	R:R:I223	6.28	Yes	No	0	7	5
321	R:R:E224	R:R:R227	12.79	No	No	0	6	4
322	R:R:E224	S:S:E224	3.81	No	No	0	6	6
323	R:R:E228	R:R:K225	4.05	No	Yes	0	3	3
324	R:R:E229	R:R:K225	13.5	Yes	Yes	0	5	3
325	R:R:F226	R:R:V268	10.49	No	Yes	0	6	6
326	R:R:E231	R:R:R227	8.14	No	No	0	4	4
327	R:R:R227	S:S:R227	9.6	No	Yes	0	4	4
328	R:R:E229	R:R:R233	3.49	Yes	Yes	0	5	4
329	R:R:A230	R:R:I235	4.87	No	Yes	0	6	7
330	R:R:I235	R:R:R233	3.76	Yes	Yes	0	7	4
331	R:R:D234	S:S:G557	5.03	No	No	25	5	6
332	R:R:C236	R:R:P559	3.77	No	No	0	9	6
333	R:R:C236	R:R:C561	7.28	No	No	30	9	9
334	R:R:D238	R:R:F239	3.58	Yes	Yes	9	8	6
335	R:R:D238	R:R:S262	7.36	Yes	No	9	8	7
336	R:R:A264	R:R:D238	3.09	No	Yes	9	7	8
337	R:R:F239	R:R:I259	3.77	Yes	No	0	6	6
338	R:R:F239	R:R:S262	5.28	Yes	No	9	6	7
339	R:R:F239	R:R:I267	3.77	Yes	No	9	6	7
340	R:R:E241	R:R:H254	8.62	No	No	0	5	3
341	R:R:E241	R:R:V255	7.13	No	Yes	0	5	5
342	R:R:E241	R:R:V258	4.28	No	No	0	5	4
343	R:R:I243	R:R:V255	3.07	Yes	Yes	31	5	5
344	R:R:I243	R:R:S271	3.1	Yes	No	0	5	4
345	R:R:I243	R:R:L279	5.71	Yes	No	31	5	5
346	R:R:Q245	R:R:Y246	11.27	No	No	0	4	3
347	R:R:P274	R:R:Q245	4.74	Yes	No	0	3	4
348	R:R:Y246	S:S:N178	18.61	No	No	0	3	3
349	R:R:D248	R:R:E250	6.5	No	No	0	3	2
350	R:R:D248	R:R:E251	14.29	No	No	0	3	4
351	R:R:E249	R:R:I252	4.1	No	No	0	2	4
352	R:R:I252	R:R:L279	4.28	No	No	0	4	5
353	R:R:E282	R:R:Q253	6.37	Yes	No	19	6	3
354	R:R:Q253	R:R:R286	11.68	No	Yes	19	3	4
355	R:R:I259	R:R:V255	3.07	No	Yes	0	6	5
356	R:R:L279	R:R:V255	5.96	No	Yes	31	5	5
357	R:R:E282	R:R:V256	4.28	Yes	No	19	6	5
358	R:R:I283	R:R:V256	4.61	No	No	0	4	5
359	R:R:R286	R:R:V256	5.23	Yes	No	19	4	5
360	R:R:Q260	R:R:R286	8.18	No	Yes	0	5	4
361	R:R:I288	R:R:Q260	6.86	No	No	0	4	5
362	R:R:K265	R:R:S540	3.06	No	No	0	5	9
363	R:R:I292	R:R:V266	6.14	No	Yes	0	7	7
364	R:R:S540	R:R:V266	3.23	No	Yes	6	9	7
365	R:R:I267	R:R:K291	4.36	No	No	9	7	6
366	R:R:I267	R:R:W293	7.05	No	No	9	7	8
367	R:R:L294	R:R:V268	4.47	No	Yes	0	7	6
368	R:R:V269	R:R:W299	9.81	No	Yes	0	5	7
369	R:R:F270	R:R:S296	5.28	Yes	No	0	7	8
370	R:R:D275	R:R:S272	7.36	No	No	0	5	5
371	R:R:S272	W:W:W1	3.71	No	Yes	0	5	0
372	R:R:G273	R:R:P274	4.06	No	Yes	0	4	3
373	R:R:G273	R:R:S302	3.71	No	No	0	4	5
374	R:R:L304	R:R:P274	3.28	No	Yes	26	2	3
375	R:R:L276	R:R:W299	10.25	No	Yes	12	5	7
376	R:R:I305	R:R:L276	4.28	Yes	No	12	4	5
377	R:R:E277	R:R:P278	3.14	Yes	No	0	2	2
378	R:R:E277	R:R:K281	5.4	Yes	No	0	2	2
379	R:R:E277	R:R:L304	6.63	Yes	No	0	2	2
380	R:R:I280	R:R:I305	4.42	No	Yes	0	5	4
381	R:R:I280	R:R:V314	3.07	No	No	0	5	7
382	R:R:K281	R:R:Y310	4.78	No	Yes	0	2	3
383	R:R:E282	R:R:R285	8.14	Yes	No	19	6	3
384	R:R:E282	R:R:R286	3.49	Yes	Yes	19	6	4
385	R:R:I283	R:R:I288	7.36	No	No	0	4	4
386	R:R:I283	R:R:V313	4.61	No	Yes	0	4	3
387	R:R:V284	R:R:Y310	10.09	No	Yes	13	3	3
388	R:R:H312	R:R:V284	8.3	No	No	13	3	3
389	R:R:V284	R:R:V313	6.41	No	Yes	13	3	3
390	R:R:R285	R:R:R286	3.2	No	Yes	19	3	4
391	R:R:N287	R:R:T289	4.39	No	No	0	6	5
392	R:R:H312	R:R:N287	5.1	No	No	0	3	6
393	R:R:G290	R:R:T289	3.64	No	No	0	4	5
394	R:R:K291	R:R:W293	3.48	No	No	9	6	8
395	R:R:I292	R:R:P538	6.77	No	No	0	7	8
396	R:R:T317	R:R:W293	7.28	No	No	0	7	8
397	R:R:A295	R:R:W299	10.37	No	Yes	0	7	7
398	R:R:E297	R:R:L322	10.6	No	No	0	8	4
399	R:R:E297	W:W:W1	5.45	No	Yes	0	8	0
400	R:R:A298	W:W:W1	5.19	No	Yes	0	6	0
401	R:R:I305	R:R:W299	5.87	Yes	Yes	12	4	7
402	R:R:W299	R:R:W494	4.69	Yes	Yes	12	7	7
403	R:R:I305	R:R:W494	3.52	Yes	Yes	12	4	7
404	R:R:A306	R:R:W494	6.48	No	Yes	12	4	7
405	R:R:A306	R:R:I503	4.87	No	Yes	12	4	4
406	R:R:M307	R:R:Q309	6.8	No	No	13	3	3
407	R:R:M307	R:R:Y310	5.99	No	Yes	13	3	3
408	R:R:Q309	R:R:Y310	3.38	No	Yes	13	3	3
409	R:R:F311	R:R:G315	6.02	Yes	No	0	3	4
410	R:R:F311	R:R:L496	24.36	Yes	No	0	3	3
411	R:R:F311	R:R:I503	5.02	Yes	Yes	0	3	4
412	R:R:F311	R:R:G532	4.52	Yes	No	0	3	1
413	R:R:H312	R:R:V313	5.54	No	Yes	13	3	3
414	R:R:V313	R:R:V314	3.21	Yes	No	0	3	7
415	R:R:V314	R:R:W494	4.9	No	Yes	0	7	7
416	R:R:G316	R:R:N493	5.09	No	No	0	8	9
417	R:R:T317	R:R:W494	12.13	No	Yes	0	7	7
418	R:R:F320	R:R:Y489	4.13	Yes	Yes	29	6	8
419	R:R:F320	R:R:I491	6.28	Yes	Yes	0	6	8
420	R:R:A321	R:R:R415	6.91	No	No	0	5	5
421	R:R:L322	R:R:N419	4.12	No	No	28	4	7
422	R:R:K323	R:R:N488	4.2	No	No	0	5	4
423	R:R:K323	R:R:S490	7.65	No	No	0	5	8
424	R:R:A324	R:R:H413	4.39	No	No	0	5	7
425	R:R:G325	R:R:Y418	10.14	No	Yes	2	4	7
426	R:R:G325	R:R:M473	3.49	No	No	2	4	4
427	R:R:M473	R:R:Q326	5.44	No	No	0	4	3
428	R:R:I327	R:R:P328	3.39	Yes	No	0	6	4
429	R:R:F330	R:R:I327	6.28	Yes	Yes	2	8	6
430	R:R:I327	R:R:L414	4.28	Yes	Yes	2	6	6
431	R:R:I327	R:R:Y418	3.63	Yes	Yes	2	6	7
432	R:R:I327	R:R:Y421	12.09	Yes	Yes	2	6	8
433	R:R:F330	R:R:L334	15.83	Yes	Yes	2	8	6
434	R:R:F330	R:R:L414	6.09	Yes	Yes	2	8	6
435	R:R:E332	R:R:R331	3.49	No	Yes	0	5	4
436	R:R:K335	R:R:R331	9.9	No	Yes	2	4	4
437	R:R:I409	R:R:R331	12.53	No	Yes	2	5	4
438	R:R:R331	R:R:Y411	8.23	Yes	Yes	2	4	5
439	R:R:L334	R:R:Y408	11.72	Yes	Yes	2	6	3
440	R:R:L334	R:R:Y411	3.52	Yes	Yes	2	6	5
441	R:R:I409	R:R:K335	4.36	No	No	2	5	4
442	R:R:F351	R:R:V337	3.93	Yes	No	2	6	5
443	R:R:V337	R:R:Y408	5.05	No	Yes	2	5	3
444	R:R:H338	R:R:P339	9.15	No	No	0	4	7
445	R:R:H338	R:R:R340	6.77	No	No	0	4	4
446	R:R:H338	R:R:K341	3.93	No	No	0	4	3
447	R:R:P339	R:R:W352	25.67	No	No	0	7	8
448	R:R:L360	R:R:P339	3.28	Yes	No	0	4	7
449	R:R:A348	R:R:S342	3.42	No	No	0	5	3
450	R:R:F347	R:R:N345	3.62	Yes	Yes	2	5	8
451	R:R:F351	R:R:I401	3.77	Yes	No	0	6	7
452	R:R:F351	R:R:Y408	11.35	Yes	Yes	2	6	3
453	R:R:F356	R:R:W352	18.04	Yes	No	20	8	8
454	R:R:E399	R:R:W352	4.36	Yes	No	20	8	8
455	R:R:E353	R:R:L360	7.95	No	Yes	0	7	4
456	R:R:F356	R:R:T355	6.49	Yes	Yes	20	8	4
457	R:R:I401	R:R:T355	4.56	No	Yes	0	7	4
458	R:R:T355	R:R:V404	4.76	Yes	No	20	4	4
459	R:R:T355	R:R:T406	3.14	Yes	No	0	4	4
460	R:R:E399	R:R:F356	8.16	Yes	Yes	20	8	8
461	R:R:F356	R:R:V404	3.93	Yes	No	20	8	4
462	R:R:N357	R:R:R392	3.62	No	No	0	3	1
463	R:R:C358	R:R:C395	7.28	No	No	0	9	9
464	R:R:H359	R:R:Q361	11.13	No	No	0	4	1
465	R:R:C395	R:R:L360	7.94	No	Yes	0	9	4
466	R:R:P393	R:R:R392	5.76	No	No	0	1	1
467	R:R:E399	R:R:T396	9.88	Yes	No	0	8	6
468	R:R:N400	R:R:S402	8.94	No	No	0	4	4
469	R:R:D410	R:R:E405	3.9	No	No	0	6	4
470	R:R:L414	R:R:Y411	11.72	Yes	Yes	2	6	5
471	R:R:H413	R:R:T412	9.58	No	No	0	7	5
472	R:R:H413	R:R:R415	12.41	No	No	0	7	5
473	R:R:L414	R:R:S417	6.01	Yes	Yes	2	6	6
474	R:R:I416	W:W:W1	5.87	Yes	Yes	2	4	0
475	R:R:I416	W:W:?2	9.85	Yes	Yes	2	4	0
476	R:R:S417	W:W:?2	5.18	Yes	Yes	2	6	0
477	R:R:L422	R:R:Y418	7.03	No	Yes	2	8	7
478	R:R:N471	R:R:Y418	4.65	Yes	Yes	2	6	7
479	R:R:N472	R:R:Y418	4.65	No	Yes	0	4	7
480	R:R:M473	R:R:Y418	9.58	No	Yes	2	4	7
481	R:R:Y421	R:R:Y425	17.87	Yes	No	2	8	8
482	R:R:N472	R:R:Y421	5.81	No	Yes	0	4	8
483	R:R:L422	R:R:N471	4.12	No	Yes	2	8	6
484	R:R:F479	R:R:S426	6.61	No	No	0	8	7
485	R:R:F469	R:R:H429	21.5	No	No	0	8	6
486	R:R:A430	R:R:L464	3.15	No	Yes	0	8	7
487	R:R:Q432	R:R:Y435	3.38	Yes	Yes	0	7	3
488	R:R:Q432	R:R:T436	9.92	Yes	No	0	7	4
489	R:R:D433	R:R:H463	8.82	No	Yes	0	4	5
490	R:R:A450	R:R:I434	4.87	No	No	0	3	6
491	R:R:I434	R:R:V455	3.07	No	No	0	6	4
492	R:R:H463	R:R:I434	11.93	Yes	No	0	5	6
493	R:R:I452	R:R:Y435	8.46	No	Yes	0	3	3
494	R:R:C437	R:R:C449	7.28	No	No	33	6	7
495	R:R:L438	R:R:P439	4.93	No	No	0	3	2
496	R:R:H463	R:R:L443	10.29	Yes	No	0	5	3
497	R:R:H466	R:R:L443	5.14	No	No	0	4	3
498	R:R:F444	R:R:S448	3.96	Yes	No	14	3	3
499	R:R:F444	R:R:Q459	4.68	Yes	Yes	14	3	7
500	R:R:F444	R:R:H463	5.66	Yes	Yes	0	3	5
501	R:R:F444	S:S:K52	9.93	Yes	Yes	14	3	3
502	R:R:T445	S:S:K52	9.01	No	Yes	0	1	3
503	R:R:S448	S:S:K52	3.06	No	Yes	14	3	3
504	R:R:A450	R:R:Q459	7.58	No	Yes	0	3	7
505	R:R:D451	R:R:K453	5.53	No	No	34	3	2
506	R:R:D451	R:R:K454	5.53	No	No	34	3	3
507	R:R:K453	R:R:K454	14.37	No	No	34	2	3
508	R:R:E456	R:R:W458	6.54	No	Yes	14	5	4
509	R:R:E456	R:R:Q459	3.82	No	Yes	14	5	7
510	R:R:Q459	R:R:W458	15.33	Yes	Yes	14	7	4
511	R:R:W458	S:S:D50	3.35	Yes	Yes	0	4	3
512	R:R:W458	S:S:K52	4.64	Yes	Yes	14	4	3
513	R:R:W458	S:S:R54	5	Yes	No	0	4	2
514	R:R:W458	S:S:P55	12.16	Yes	No	0	4	6
515	R:R:L461	R:R:R465	6.07	No	Yes	0	7	5
516	R:R:H466	R:R:K462	10.48	No	Yes	0	4	4
517	R:R:K462	S:S:D50	11.06	Yes	Yes	0	4	3
518	R:R:K462	S:S:L51	4.23	Yes	No	0	4	6
519	R:R:H466	R:R:R465	3.39	No	Yes	0	4	5
520	R:R:R465	S:S:D48	10.72	Yes	No	0	5	2
521	R:R:R465	S:S:D50	4.76	Yes	Yes	0	5	3
522	R:R:F469	R:R:L467	3.65	No	No	0	8	7
523	R:R:N468	R:R:Q476	6.6	No	No	0	6	3
524	R:R:N468	R:R:T478	5.85	No	No	0	6	3
525	R:R:F469	R:R:V477	13.11	No	No	0	8	6
526	R:R:Q476	R:R:T470	5.67	No	No	0	3	5
527	R:R:E475	R:R:N471	5.26	No	Yes	0	5	6
528	R:R:N471	R:R:V477	4.43	Yes	No	0	6	6
529	R:R:D480	R:R:D484	5.32	No	Yes	0	7	8
530	R:R:C482	R:R:D484	4.67	No	Yes	5	7	8
531	R:R:V486	R:R:V513	3.21	No	No	0	3	3
532	R:R:V486	R:R:Y514	5.05	No	No	0	3	4
533	R:R:N488	R:R:N512	5.45	No	Yes	32	4	4
534	R:R:N488	R:R:Y514	6.98	No	No	32	4	4
535	R:R:Y489	R:R:Y511	3.97	Yes	Yes	0	8	5
536	R:R:E507	R:R:S490	4.31	No	No	0	5	8
537	R:R:I491	R:R:V508	3.07	Yes	No	0	8	7
538	R:R:I491	R:R:I523	4.42	Yes	Yes	0	8	6
539	R:R:F505	R:R:I492	6.28	No	No	0	4	5
540	R:R:H495	R:R:N493	8.93	No	No	0	7	9
541	R:R:I503	R:R:W494	4.7	Yes	Yes	12	4	7
542	R:R:F505	R:R:W494	11.02	No	Yes	0	4	7
543	R:R:H495	R:R:K506	18.34	No	No	0	7	5
544	R:R:H495	R:R:L529	11.57	No	No	0	7	4
545	R:R:P498	R:R:S497	3.56	No	Yes	0	3	3
546	R:R:D500	R:R:S497	8.83	No	Yes	0	4	3
547	R:R:S497	R:R:V504	3.23	Yes	No	0	3	3
548	R:R:E499	R:R:P498	6.29	No	No	0	4	3
549	R:R:E507	R:R:G509	3.27	No	No	0	5	9
550	R:R:I528	R:R:V508	9.22	No	No	0	7	7
551	R:R:F522	R:R:Y510	17.54	No	No	0	1	3
552	R:R:R520	R:R:Y511	13.38	No	Yes	0	3	5
553	R:R:N512	R:R:Y514	8.14	Yes	No	32	4	4
554	R:R:A515	R:R:N512	4.69	No	Yes	0	4	4
555	R:R:K517	R:R:R520	12.38	No	No	0	1	3
556	R:R:I523	R:R:L521	5.71	Yes	No	6	6	5
557	R:R:E526	R:R:N524	10.52	No	No	0	3	5
558	R:R:K527	R:R:N524	5.6	No	No	0	3	5
559	R:R:E525	R:R:W530	7.63	No	Yes	6	4	8
560	R:R:E525	R:R:R535	5.82	No	No	0	4	4
561	R:R:I528	R:R:W530	10.57	No	Yes	0	7	8
562	R:R:V537	R:R:W530	6.13	No	Yes	6	4	8
563	R:R:P538	R:R:W530	14.86	No	Yes	6	8	8
564	R:R:F533	R:R:S531	3.96	No	No	0	1	4
565	R:R:P538	R:R:V537	3.53	No	No	6	8	4
566	R:R:F539	R:R:N541	8.46	No	No	0	1	5
567	R:R:F539	R:R:R544	18.17	No	No	0	1	5
568	R:R:C542	R:R:C562	7.28	No	No	9	9	9
569	R:R:F563	R:R:S543	9.25	Yes	No	0	7	8
570	R:R:D545	R:R:D578	14.64	No	No	0	5	7
571	R:R:C546	R:R:T550	5.07	No	No	15	9	6
572	R:R:C546	R:R:C565	7.28	No	No	15	9	9
573	R:R:A548	R:R:T596	3.36	No	No	0	4	5
574	R:R:G549	R:R:S574	3.71	No	No	0	9	8
575	R:R:C565	R:R:T550	3.38	No	No	15	9	6
576	R:R:R551	R:R:V566	5.23	No	No	0	7	4
577	R:R:R551	S:S:R551	23.46	No	No	0	7	7
578	R:R:F563	R:R:K552	14.89	Yes	No	15	7	8
579	R:R:D578	R:R:K552	6.91	No	No	15	7	8
580	R:R:K552	S:S:I554	8.72	No	No	0	8	3
581	R:R:I554	S:S:K552	18.9	No	No	0	3	8
582	R:R:I554	S:S:S580	3.1	No	No	0	3	4
583	R:R:E558	R:R:I555	8.2	No	No	0	5	5
584	R:R:E556	S:S:S580	10.06	No	No	0	6	4
585	R:R:G557	S:S:D234	5.03	No	No	24	6	5
586	R:R:E558	R:R:P559	3.14	No	No	0	5	6
587	R:R:C562	R:R:E558	9.12	No	No	0	9	5
588	R:R:D578	R:R:F563	3.58	No	Yes	15	7	7
589	R:R:E567	R:R:V566	4.28	No	No	0	4	4
590	R:R:C568	R:R:S574	5.16	No	No	0	9	8
591	R:R:C568	R:R:C582	7.28	No	No	0	9	9
592	R:R:E572	R:R:P569	7.86	No	No	0	7	5
593	R:R:P569	S:S:P569	7.79	No	No	0	5	5
594	R:R:G571	R:R:W590	5.63	No	Yes	0	7	6
595	R:R:C582	R:R:E572	3.04	No	No	0	9	7
596	R:R:E572	R:R:K584	10.8	No	No	0	7	4
597	R:R:N583	R:R:Y573	9.3	No	No	0	1	6
598	R:R:C598	R:R:Y573	5.38	No	No	0	9	6
599	R:R:S580	S:S:I554	3.1	No	No	0	4	3
600	R:R:S580	S:S:E556	7.19	No	No	0	4	6
601	R:R:C585	R:R:P586	5.65	No	No	0	9	4
602	R:R:C585	R:R:C598	7.28	No	No	0	9	9
603	R:R:F589	R:R:P586	4.33	No	No	0	5	4
604	R:R:D588	R:R:F589	8.36	No	No	0	6	5
605	R:R:A600	R:R:F589	4.16	No	No	0	4	5
606	R:R:S591	R:R:W590	3.71	No	Yes	0	8	6
607	R:R:D758	R:R:W590	5.58	No	Yes	0	4	6
608	R:R:E759	R:R:W590	6.54	No	Yes	0	4	6
609	R:R:E593	R:R:N592	3.94	No	No	0	2	7
610	R:R:E593	R:R:N594	6.57	No	No	0	2	3
611	R:R:K601	R:R:Q754	4.07	No	No	0	8	4
612	R:R:E604	R:R:F762	11.66	No	Yes	0	6	7
613	R:R:E604	R:R:K831	10.8	No	No	0	6	9
614	R:R:F605	R:R:S607	9.25	No	No	0	7	7
615	R:R:E671	R:R:F605	3.5	No	No	0	4	7
616	R:R:I669	R:R:L606	4.28	Yes	No	0	8	9
617	R:R:L606	R:R:S834	4.5	No	No	0	9	8
618	R:R:S607	R:R:T609	3.2	No	No	0	7	4
619	R:R:E610	R:R:S607	7.19	No	No	0	7	7
620	R:R:T617	R:R:W608	3.64	Yes	Yes	36	5	5
621	R:R:L666	R:R:W608	3.42	No	Yes	0	7	5
622	R:R:I669	R:R:W608	8.22	Yes	Yes	36	8	5
623	R:R:G670	R:R:W608	4.22	No	Yes	0	7	5
624	R:R:E610	R:R:P611	3.14	No	No	0	7	4
625	R:R:I614	R:R:T617	3.04	No	Yes	0	6	5
626	R:R:L616	R:R:V838	7.45	No	Yes	0	8	7
627	R:R:I669	R:R:T617	3.04	Yes	Yes	36	8	5
628	R:R:A620	R:R:L842	3.15	No	No	0	7	9
629	R:R:F662	R:R:G623	4.52	No	No	0	8	6
630	R:R:I624	R:R:L659	4.28	No	No	0	5	4
631	R:R:F662	R:R:I624	3.77	No	No	0	8	5
632	R:R:F854	R:R:L626	6.09	No	No	0	4	4
633	R:R:L659	R:R:T627	4.42	No	No	0	4	7
634	R:R:L849	R:R:T627	5.9	No	No	0	8	7
635	R:R:L655	R:R:V630	7.45	No	Yes	7	9	7
636	R:R:F853	R:R:V630	3.93	Yes	Yes	7	9	7
637	R:R:I857	R:R:V630	4.61	No	Yes	0	8	7
638	R:R:I635	R:R:L631	5.71	Yes	No	7	4	4
639	R:R:L631	R:R:Y652	3.52	No	Yes	7	4	7
640	R:R:L631	R:R:L655	6.92	No	No	7	4	9
641	R:R:I857	R:R:V633	4.61	No	No	0	8	5
642	R:R:F634	R:R:V643	3.93	Yes	No	0	9	9
643	R:R:F634	R:R:S651	6.61	Yes	No	7	9	9
644	R:R:F634	R:R:Y652	5.16	Yes	Yes	7	9	7
645	R:R:F634	R:R:F853	5.36	Yes	Yes	7	9	9
646	R:R:I635	R:R:R638	3.76	Yes	No	7	4	6
647	R:R:I635	R:R:Y652	6.04	Yes	Yes	7	4	7
648	R:R:F637	R:R:K636	13.65	No	No	0	4	4
649	R:R:R638	R:R:R648	6.4	No	Yes	0	6	8
650	R:R:R638	R:R:Y652	4.12	No	Yes	7	6	7
651	R:R:N639	R:R:R648	4.82	No	Yes	0	4	8
652	R:R:P641	R:R:T640	5.25	No	No	0	8	9
653	R:R:T640	R:R:V643	6.35	No	No	0	9	9
654	R:R:I642	R:R:I860	7.36	No	No	0	7	9
655	R:R:I860	R:R:V643	3.07	No	No	0	9	9
656	R:R:K698	R:R:T646	9.01	No	No	0	9	9
657	R:R:E803	R:R:T646	4.23	No	No	7	9	9
658	R:R:K856	R:R:T646	9.01	No	No	7	9	9
659	R:R:L650	R:R:N647	6.87	Yes	No	22	8	9
660	R:R:N647	R:R:R701	14.46	No	No	22	9	8
661	R:R:N647	R:R:Q724	9.24	No	Yes	22	9	8
662	R:R:E649	R:R:R648	4.65	No	Yes	0	7	8
663	R:R:E649	R:R:Q724	8.92	No	Yes	0	7	8
664	R:R:E649	R:R:F725	4.66	No	No	0	7	5
665	R:R:K698	R:R:L650	4.23	No	Yes	0	9	8
666	R:R:L650	R:R:Q724	3.99	Yes	Yes	22	8	8
667	R:R:L650	R:R:V728	4.47	Yes	Yes	0	8	7
668	R:R:S651	R:R:Y652	3.82	No	Yes	7	9	7
669	R:R:C694	R:R:L653	4.76	No	No	0	6	5
670	R:R:F725	R:R:L653	4.87	No	No	0	5	5
671	R:R:C691	R:R:L654	3.17	Yes	Yes	0	8	8
672	R:R:C694	R:R:L654	6.35	No	Yes	0	6	8
673	R:R:I695	R:R:L654	4.28	Yes	Yes	0	7	8
674	R:R:F853	R:R:L654	6.09	Yes	Yes	0	9	8
675	R:R:F853	R:R:L655	10.96	Yes	No	7	9	9
676	R:R:C660	R:R:F656	8.38	No	No	0	7	4
677	R:R:L690	R:R:S657	7.51	No	No	0	7	9
678	R:R:C691	R:R:S657	5.16	Yes	No	0	8	9
679	R:R:C691	R:R:L658	4.76	Yes	No	37	8	8
680	R:R:L658	R:R:L848	11.07	No	No	37	8	7
681	R:R:L658	R:R:L849	4.15	No	No	0	8	8
682	R:R:C660	R:R:S687	3.44	No	No	0	7	6
683	R:R:C661	R:R:F684	4.19	No	Yes	0	7	8
684	R:R:C661	R:R:S845	5.16	No	No	0	7	8
685	R:R:F662	R:R:S845	7.93	No	No	0	8	8
686	R:R:F684	R:R:S664	5.28	Yes	No	0	8	6
687	R:R:S665	R:R:V838	4.85	No	Yes	0	8	7
688	R:R:L842	R:R:S665	7.51	No	No	0	9	8
689	R:R:F667	R:R:T676	3.89	No	No	0	5	7
690	R:R:F668	R:R:R680	18.17	Yes	No	0	9	8
691	R:R:E837	R:R:F668	9.33	No	Yes	0	9	9
692	R:R:F668	R:R:I841	3.77	Yes	No	0	9	9
693	R:R:I669	R:R:V838	3.07	Yes	Yes	0	8	7
694	R:R:E671	R:R:P672	11	No	No	35	4	9
695	R:R:E671	R:R:I763	6.83	No	Yes	35	4	7
696	R:R:I763	R:R:P672	8.47	Yes	No	35	7	9
697	R:R:Q673	R:R:W675	16.43	No	No	0	4	3
698	R:R:D674	R:R:R678	13.1	No	Yes	0	3	5
699	R:R:D674	R:R:S749	5.89	No	No	0	3	5
700	R:R:T676	R:R:W675	4.85	No	No	0	7	3
701	R:R:C677	R:R:C765	5.46	No	No	0	9	9
702	R:R:L743	R:R:R678	3.64	No	Yes	0	7	5
703	R:R:P747	R:R:R678	4.32	No	Yes	0	8	5
704	R:R:C765	R:R:R680	9.75	No	No	0	9	8
705	R:R:Q681	R:R:W742	6.57	No	Yes	0	9	9
706	R:R:L773	R:R:Q681	13.31	No	No	0	8	9
707	R:R:Q681	W:W:?4	6.8	No	Yes	0	9	0
708	R:R:C739	R:R:P682	7.53	No	No	0	7	5
709	R:R:P682	R:R:W742	6.76	No	Yes	0	5	9
710	R:R:F684	R:R:F688	7.5	Yes	No	0	8	8
711	R:R:F684	R:R:I841	17.58	Yes	No	0	8	9
712	R:R:F684	W:W:?4	18.66	Yes	Yes	0	8	0
713	R:R:I686	R:R:I736	4.42	No	No	0	7	5
714	R:R:F688	R:R:I692	8.79	No	No	0	8	7
715	R:R:F688	R:R:F814	13.93	No	Yes	0	8	9
716	R:R:Q735	R:R:V689	14.33	Yes	No	39	9	7
717	R:R:V689	R:R:Y779	3.79	No	Yes	39	7	9
718	R:R:L690	R:R:T732	7.37	No	No	0	7	7
719	R:R:C691	R:R:L848	3.17	Yes	No	37	8	7
720	R:R:C787	R:R:I692	3.27	Yes	No	0	8	7
721	R:R:S693	R:R:V728	8.08	No	Yes	0	9	7
722	R:R:C731	R:R:S693	5.16	No	No	0	5	9
723	R:R:S693	R:R:T732	3.2	No	No	0	9	7
724	R:R:C694	R:R:V728	3.42	No	Yes	0	6	7
725	R:R:C787	R:R:I695	3.27	Yes	Yes	0	8	7
726	R:R:I695	R:R:I807	4.42	Yes	No	0	7	9
727	R:R:I695	R:R:I852	4.42	Yes	No	0	7	9
728	R:R:I786	R:R:L696	4.28	No	No	0	4	8
729	R:R:C787	R:R:L696	3.17	Yes	No	0	8	8
730	R:R:F790	R:R:L696	8.53	Yes	No	0	7	8
731	R:R:V697	R:R:V728	4.81	No	Yes	0	8	7
732	R:R:F790	R:R:N700	9.67	Yes	No	0	7	7
733	R:R:Q724	R:R:R701	16.35	Yes	No	22	8	8
734	R:R:F801	R:R:V702	6.55	Yes	No	0	9	9
735	R:R:L704	R:R:W719	11.39	No	No	0	8	6
736	R:R:F706	R:R:V705	3.93	Yes	No	0	9	9
737	R:R:F706	R:R:L797	4.87	Yes	Yes	0	9	8
738	R:R:F706	R:R:P798	5.78	Yes	No	0	9	9
739	R:R:F706	R:R:F801	5.36	Yes	Yes	0	9	9
740	R:R:E707	R:R:K709	6.75	No	No	0	6	8
741	R:R:F733	R:R:I736	3.77	No	No	0	4	5
742	R:R:M734	R:R:Y779	8.38	No	Yes	0	4	9
743	R:R:L776	R:R:Q735	10.65	No	Yes	0	8	9
744	R:R:Q735	R:R:Y779	7.89	Yes	Yes	39	9	9
745	R:R:Q735	R:R:T780	5.67	Yes	No	0	9	7
746	R:R:I741	R:R:V737	3.07	No	No	0	4	3
747	R:R:I738	R:R:L776	4.28	No	No	0	8	8
748	R:R:C739	R:R:L743	3.17	No	No	0	7	7
749	R:R:P748	R:R:W742	8.11	No	Yes	0	9	9
750	R:R:S769	R:R:W742	4.94	No	Yes	0	9	9
751	R:R:A772	R:R:W742	7.78	No	Yes	0	6	9
752	R:R:A746	R:R:S769	3.42	No	No	0	6	9
753	R:R:I763	R:R:S750	3.1	Yes	No	0	7	6
754	R:R:N753	R:R:Y751	15.12	Yes	Yes	40	7	3
755	R:R:E755	R:R:Y751	5.61	No	Yes	40	4	3
756	R:R:T764	R:R:Y751	3.75	No	Yes	0	7	3
757	R:R:I761	R:R:R752	3.76	No	No	0	7	3
758	R:R:I763	R:R:R752	5.01	Yes	No	0	7	3
759	R:R:E755	R:R:N753	7.89	No	Yes	40	4	7
760	R:R:L756	R:R:N753	5.49	No	Yes	0	5	7
761	R:R:E755	R:R:Q754	14.02	No	No	0	4	4
762	R:R:I761	R:R:Q754	5.49	No	No	0	7	4
763	R:R:E757	R:R:I760	8.2	No	No	0	4	5
764	R:R:E757	R:R:F762	5.83	No	Yes	0	4	7
765	R:R:F762	R:R:G830	7.53	Yes	No	0	7	8
766	R:R:E767	R:R:H766	3.69	No	No	0	7	6
767	R:R:G768	R:R:H766	3.18	No	No	0	7	6
768	R:R:F775	R:R:M771	3.73	No	No	0	4	3
769	R:R:I777	R:R:L773	4.28	No	No	0	8	8
770	R:R:L776	W:W:?4	4.04	No	Yes	0	8	0
771	R:R:G778	R:R:I777	3.53	No	No	0	5	8
772	R:R:I777	W:W:?4	16.66	No	Yes	0	8	0
773	R:R:L783	R:R:Y779	12.89	No	Yes	0	9	9
774	R:R:T780	W:W:?4	6.45	No	Yes	0	7	0
775	R:R:C781	R:R:F815	5.59	No	No	0	7	7
776	R:R:A784	R:R:F815	4.16	No	No	0	8	7
777	R:R:C787	R:R:M811	6.48	Yes	No	0	8	9
778	R:R:F788	R:R:T808	6.49	No	No	0	8	9
779	R:R:F788	R:R:M811	9.95	No	No	0	8	9
780	R:R:F788	R:R:L812	4.87	No	No	0	8	9
781	R:R:A791	R:R:I807	4.87	No	No	0	9	9
782	R:R:F792	R:R:R795	3.21	No	No	0	8	9
783	R:R:L797	R:R:S794	7.51	Yes	No	0	8	9
784	R:R:K796	R:R:R795	18.56	No	No	0	7	9
785	R:R:A804	R:R:N802	4.69	No	No	0	9	9
786	R:R:E803	R:R:K856	10.8	No	No	7	9	9
787	R:R:K805	S:S:K805	4.31	No	Yes	23	9	9
788	R:R:K805	S:S:F809	3.72	No	Yes	23	9	9
789	R:R:F806	R:R:N855	13.29	No	No	0	5	9
790	R:R:F809	S:S:F809	7.5	No	Yes	0	9	9
791	R:R:F809	S:S:L812	4.87	No	No	0	9	9
792	R:R:L848	R:R:S810	6.01	No	No	0	7	9
793	R:R:C851	R:R:S810	5.16	No	No	0	8	9
794	R:R:G847	R:R:I813	3.53	No	No	0	8	8
795	R:R:I813	S:S:I816	5.89	No	No	0	8	8
796	R:R:F814	R:R:F815	10.72	Yes	No	0	9	7
797	R:R:F814	R:R:W818	8.02	Yes	No	38	9	9
798	R:R:F814	W:W:?4	3.56	Yes	Yes	38	9	0
799	R:R:I816	S:S:V817	4.61	No	No	0	8	9
800	R:R:A843	R:R:V817	5.09	No	No	0	7	9
801	R:R:A840	R:R:W818	7.78	No	No	0	9	9
802	R:R:W818	W:W:?4	33.25	No	Yes	38	9	0
803	R:R:F821	R:R:S820	3.96	Yes	No	0	9	7
804	R:R:S820	S:S:S820	4.89	No	No	0	7	7
805	R:R:S820	S:S:A824	3.42	No	No	0	7	7
806	R:R:F821	R:R:V836	9.18	Yes	No	0	9	8
807	R:R:F821	R:R:I839	5.02	Yes	No	0	9	7
808	R:R:F821	S:S:P823	7.22	Yes	No	0	9	9
809	R:R:I822	R:R:P823	3.39	No	No	0	7	9
810	R:R:I822	W:W:?4	4.17	No	Yes	0	7	0
811	R:R:P823	S:S:F612	5.78	No	No	0	9	8
812	R:R:P823	S:S:I839	3.39	No	No	0	9	7
813	R:R:A824	R:R:V836	3.39	No	No	41	7	8
814	R:R:A824	S:S:S827	3.42	No	No	41	7	8
815	R:R:Y825	W:W:?4	11.12	No	Yes	0	9	0
816	R:R:S827	S:S:T828	3.2	No	No	0	8	8
817	R:R:S827	S:S:F832	3.96	No	Yes	0	8	5
818	R:R:F832	R:R:T828	3.89	No	No	0	5	8
819	R:R:V833	R:R:Y829	3.79	No	No	0	6	6
820	R:R:F832	R:R:K831	12.41	No	No	0	5	9
821	R:R:V836	S:S:S827	3.23	No	No	41	8	8
822	R:R:E837	W:W:?4	11.6	No	Yes	0	9	0
823	R:R:F854	R:R:L849	3.65	No	No	0	4	8
824	R:R:A850	R:R:F854	4.16	No	No	0	1	4
825	R:R:F853	R:R:I852	10.05	Yes	No	0	9	9
826	R:R:F853	R:R:K856	4.96	Yes	No	7	9	9
827	R:R:F862	R:R:Y858	16.5	No	No	0	5	8
828	S:S:R25	S:S:Y20	11.32	No	No	0	4	2
829	S:S:G21	S:S:P22	4.06	No	No	16	3	5
830	S:S:E109	S:S:G21	4.91	No	No	16	5	3
831	S:S:F98	S:S:P22	8.67	Yes	No	16	4	5
832	S:S:E109	S:S:P22	3.14	No	No	16	5	5
833	S:S:F347	S:S:Q24	10.54	No	No	0	5	5
834	S:S:E350	S:S:Q24	5.1	No	No	0	5	5
835	S:S:Q27	S:S:R25	5.84	No	No	0	4	4
836	S:S:F98	S:S:R25	17.1	Yes	No	0	4	4
837	S:S:A26	S:S:N345	4.69	No	Yes	0	6	8
838	S:S:Q27	S:S:R96	10.51	No	Yes	0	4	4
839	S:S:K28	S:S:Y95	16.72	No	Yes	1	5	8
840	S:S:H344	S:S:K28	7.86	No	No	1	3	5
841	S:S:D31	S:S:L91	9.5	No	No	0	8	6
842	S:S:D31	S:S:T92	7.23	No	No	0	8	7
843	S:S:I32	S:S:L91	7.14	No	No	0	6	6
844	S:S:I139	S:S:I32	5.89	Yes	No	42	5	6
845	S:S:I32	S:S:L431	7.14	No	No	42	6	8
846	S:S:L34	S:S:L93	4.15	No	No	0	7	9
847	S:S:I427	S:S:L34	5.71	Yes	No	0	5	7
848	S:S:G35	S:S:V141	5.52	No	No	0	8	7
849	S:S:G36	S:S:M74	3.49	No	Yes	1	7	8
850	S:S:G36	S:S:I97	3.53	No	Yes	1	7	8
851	S:S:L37	S:S:T100	4.42	No	No	0	6	7
852	S:S:F114	S:S:L37	3.65	Yes	No	0	5	6
853	S:S:F38	S:S:L71	7.31	Yes	No	1	7	4
854	S:S:F38	S:S:M74	6.22	Yes	Yes	1	7	8
855	S:S:F38	S:S:I97	3.77	Yes	Yes	1	7	8
856	S:S:F38	S:S:Y167	12.38	Yes	Yes	1	7	8
857	S:S:F38	S:S:V420	3.93	Yes	No	1	7	7
858	S:S:P39	S:S:W70	5.4	No	Yes	1	6	5
859	S:S:N102	S:S:P39	4.89	No	No	0	3	6
860	S:S:P39	S:S:T145	8.74	No	Yes	1	6	5
861	S:S:H41	S:S:I40	5.3	Yes	No	1	7	5
862	S:S:I40	S:S:Y63	4.84	No	Yes	1	5	5
863	S:S:D99	S:S:I40	12.59	Yes	No	1	9	5
864	S:S:C60	S:S:H41	7.37	Yes	Yes	1	7	7
865	S:S:H41	S:S:Y63	5.44	Yes	Yes	1	7	5
866	S:S:D99	S:S:H41	6.3	Yes	Yes	1	9	7
867	S:S:C101	S:S:H41	5.9	Yes	Yes	1	8	7
868	S:S:E350	S:S:H41	8.62	No	Yes	1	5	7
869	S:S:F42	S:S:R62	7.48	Yes	No	0	3	4
870	S:S:F42	S:S:N64	14.5	Yes	No	0	3	4
871	S:S:F42	S:S:P274	8.67	Yes	Yes	43	3	3
872	S:S:F42	S:S:L304	14.61	Yes	No	43	3	2
873	S:S:V44	S:S:V58	8.02	No	No	0	2	1
874	S:S:C60	S:S:V44	3.42	Yes	No	0	7	2
875	S:S:T103	S:S:V44	4.76	No	No	0	4	2
876	S:S:E56	S:S:K47	10.8	No	No	0	1	2
877	S:S:C101	S:S:C60	7.28	Yes	Yes	1	8	7
878	S:S:C60	S:S:K106	3.23	Yes	No	1	7	4
879	S:S:I61	S:S:R62	5.01	No	No	0	2	4
880	S:S:F65	S:S:Y63	8.25	Yes	Yes	1	2	5
881	S:S:F68	S:S:Y63	4.13	Yes	Yes	1	7	5
882	S:S:E350	S:S:Y63	7.86	No	Yes	1	5	5
883	S:S:F351	S:S:Y63	5.16	Yes	Yes	1	6	5
884	S:S:E354	S:S:Y63	16.83	No	Yes	0	4	5
885	S:S:N64	S:S:R66	6.03	No	Yes	0	4	5
886	S:S:G67	S:S:N64	3.39	No	No	0	4	4
887	S:S:F351	S:S:F65	4.29	Yes	Yes	1	6	2
888	S:S:F65	S:S:T406	15.56	Yes	No	1	2	4
889	S:S:F65	S:S:P407	7.22	Yes	No	1	2	1
890	S:S:F65	S:S:Y408	3.09	Yes	Yes	1	2	3
891	S:S:R66	S:S:R69	3.2	Yes	Yes	1	5	8
892	S:S:R66	S:S:W70	8	Yes	Yes	1	5	5
893	S:S:R66	X:X:?2	18.17	Yes	Yes	1	5	0
894	S:S:G67	S:S:W70	5.63	No	Yes	0	4	5
895	S:S:F68	S:S:Q72	12.88	Yes	Yes	1	7	7
896	S:S:F68	S:S:N345	4.83	Yes	Yes	1	7	8
897	S:S:F347	S:S:F68	3.22	No	Yes	0	5	7
898	S:S:F351	S:S:F68	10.72	Yes	Yes	1	6	7
899	S:S:F68	S:S:Y408	11.35	Yes	Yes	1	7	3
900	S:S:R69	S:S:Y408	3.09	Yes	Yes	1	8	3
901	S:S:R69	S:S:Y411	17.49	Yes	Yes	0	8	5
902	S:S:R69	X:X:?2	5.59	Yes	Yes	1	8	0
903	S:S:T145	S:S:W70	7.28	Yes	Yes	1	5	5
904	S:S:W70	S:S:Y167	5.79	Yes	Yes	1	5	8
905	S:S:I416	S:S:W70	12.92	Yes	Yes	1	4	5
906	S:S:S417	S:S:W70	6.18	No	Yes	1	6	5
907	S:S:W70	X:X:?2	9.17	Yes	Yes	1	5	0
908	S:S:I97	S:S:L71	5.71	Yes	No	1	8	4
909	S:S:F333	S:S:Q72	9.37	Yes	Yes	1	7	7
910	S:S:N345	S:S:Q72	6.6	Yes	Yes	1	8	7
911	S:S:Q72	S:S:Y408	6.76	Yes	Yes	1	7	3
912	S:S:A73	S:S:F330	4.16	No	Yes	0	7	8
913	S:S:A73	S:S:V420	3.39	No	No	0	7	7
914	S:S:I97	S:S:M74	7.29	Yes	Yes	1	8	8
915	S:S:M74	S:S:V142	4.56	Yes	No	0	8	7
916	S:S:I75	S:S:Y95	9.67	No	Yes	0	4	8
917	S:S:F333	S:S:I75	6.28	Yes	No	0	7	4
918	S:S:E79	S:S:F76	4.66	No	Yes	1	7	7
919	S:S:E80	S:S:F76	8.16	No	Yes	1	8	7
920	S:S:F76	S:S:I327	3.77	Yes	Yes	1	7	6
921	S:S:F330	S:S:F76	5.36	Yes	Yes	1	8	7
922	S:S:F333	S:S:F76	13.93	Yes	Yes	1	7	7
923	S:S:A77	S:S:Y421	4	No	Yes	0	8	8
924	S:S:I78	S:S:Y95	4.84	No	Yes	0	6	8
925	S:S:I78	S:S:V424	3.07	No	No	0	6	8
926	S:S:E79	S:S:F333	9.33	No	Yes	1	7	7
927	S:S:E80	S:S:Y421	6.73	No	Yes	1	8	8
928	S:S:E80	S:S:Y425	4.49	No	Yes	1	8	8
929	S:S:I81	S:S:L87	5.71	No	Yes	1	9	6
930	S:S:I81	S:S:Y425	6.04	No	Yes	1	9	8
931	S:S:A428	S:S:I81	4.87	No	No	0	9	9
932	S:S:N82	S:S:T92	5.85	No	No	0	9	7
933	S:S:L93	S:S:N82	5.49	No	No	0	9	9
934	S:S:P85	S:S:S84	3.56	No	No	0	3	6
935	S:S:L87	S:S:Y425	4.69	Yes	Yes	1	6	8
936	S:S:H429	S:S:L87	5.14	No	Yes	1	6	6
937	S:S:L87	S:S:Q432	5.32	Yes	No	0	6	7
938	S:S:L88	S:S:L91	5.54	No	No	0	9	6
939	S:S:N90	S:S:P89	3.26	No	No	0	8	8
940	S:S:P89	S:S:Y435	6.95	No	No	0	8	3
941	S:S:I97	S:S:Y95	7.25	Yes	Yes	1	8	8
942	S:S:H344	S:S:Y95	3.27	No	Yes	1	3	8
943	S:S:F98	S:S:R96	4.28	Yes	Yes	16	4	4
944	S:S:F114	S:S:R96	5.34	Yes	Yes	16	5	4
945	S:S:P136	S:S:R96	7.21	No	Yes	0	4	4
946	S:S:A110	S:S:F98	4.16	No	Yes	0	5	4
947	S:S:F98	S:S:S113	6.61	Yes	No	0	4	4
948	S:S:F114	S:S:F98	6.43	Yes	Yes	16	5	4
949	S:S:C101	S:S:D99	6.22	Yes	Yes	1	8	9
950	S:S:D99	S:S:F347	4.78	Yes	No	0	9	5
951	S:S:C101	S:S:K106	4.85	Yes	No	1	8	4
952	S:S:K106	S:S:S105	3.06	No	No	0	4	4
953	S:S:T111	S:S:V153	7.93	No	No	0	7	6
954	S:S:L156	S:S:T111	5.9	No	No	0	5	7
955	S:S:F114	S:S:V141	6.55	Yes	No	0	5	7
956	S:S:F160	S:S:V115	10.49	No	No	0	7	5
957	S:S:A116	S:S:I135	3.25	No	No	0	6	4
958	S:S:I135	S:S:Q117	15.1	No	No	0	4	6
959	S:S:F160	S:S:N118	7.25	No	No	0	7	4
960	S:S:I162	S:S:N118	4.25	No	No	0	6	4
961	S:S:I120	S:S:K119	7.27	No	No	0	3	3
962	S:S:K119	S:S:L123	11.28	No	No	0	3	5
963	S:S:K119	S:S:L125	9.87	No	No	0	3	4
964	S:S:C131	S:S:I120	6.55	No	No	0	3	3
965	S:S:I135	S:S:P136	6.77	No	No	0	4	4
966	S:S:I139	S:S:L431	4.28	Yes	No	42	5	8
967	S:S:I139	S:S:V460	3.07	Yes	No	0	5	7
968	S:S:A140	S:S:I427	4.87	No	Yes	0	6	5
969	S:S:L157	S:S:V141	4.47	No	No	0	7	7
970	S:S:G143	S:S:Q164	4.93	No	Yes	0	9	8
971	S:S:A144	S:S:V149	3.39	No	No	0	6	4
972	S:S:G146	S:S:T145	3.64	No	Yes	1	5	5
973	S:S:T145	S:S:Y167	6.24	Yes	Yes	1	5	8
974	S:S:A168	S:S:T145	5.03	No	Yes	1	5	5
975	S:S:T145	X:X:W1	4.85	Yes	Yes	1	5	0
976	S:S:G146	S:S:V149	3.68	No	No	0	5	4
977	S:S:G146	X:X:W1	4.22	No	Yes	1	5	0
978	S:S:S147	S:S:S171	6.52	No	No	0	8	7
979	S:S:S147	X:X:W1	6.18	No	Yes	0	8	0
980	S:S:G148	S:S:T151	3.64	No	Yes	3	4	5
981	S:S:D217	S:S:G148	3.35	Yes	No	3	6	4
982	S:S:S150	S:S:S166	3.26	No	No	3	8	9
983	S:S:S150	S:S:S169	6.52	No	No	3	8	8
984	S:S:F183	S:S:S150	5.28	Yes	No	3	8	8
985	S:S:L174	S:S:T151	5.9	Yes	Yes	3	7	5
986	S:S:F180	S:S:T151	5.19	Yes	Yes	3	5	5
987	S:S:D217	S:S:T151	4.34	Yes	Yes	3	6	5
988	S:S:Q164	S:S:V153	7.16	Yes	No	0	8	6
989	S:S:N155	S:S:Q179	6.6	Yes	No	3	5	5
990	S:S:F180	S:S:N155	6.04	Yes	Yes	3	5	5
991	S:S:I162	S:S:L157	4.28	No	No	0	6	7
992	S:S:L157	S:S:Q164	7.99	No	Yes	0	7	8
993	S:S:G158	S:S:S182	3.71	No	No	0	6	7
994	S:S:F160	S:S:L159	3.65	No	No	0	7	5
995	S:S:K181	S:S:Y161	7.17	No	No	0	7	4
996	S:S:I162	S:S:P163	3.39	No	Yes	0	6	8
997	S:S:P163	S:S:V460	3.53	Yes	No	0	8	7
998	S:S:L461	S:S:P163	6.57	No	Yes	0	7	8
999	S:S:L464	S:S:P163	3.28	Yes	Yes	0	7	8
1000	S:S:F183	S:S:Q164	10.54	Yes	Yes	0	8	8
1001	S:S:T186	S:S:V165	3.17	No	Yes	44	8	6
1002	S:S:A423	S:S:V165	3.39	No	Yes	44	9	6
1003	S:S:S426	S:S:V165	3.23	No	Yes	0	7	6
1004	S:S:I427	S:S:V165	3.07	Yes	Yes	0	5	6
1005	S:S:S166	S:S:S169	6.52	No	No	3	9	8
1006	S:S:F183	S:S:S166	3.96	Yes	No	3	8	9
1007	S:S:I416	S:S:Y167	4.84	Yes	Yes	1	4	8
1008	S:S:V420	S:S:Y167	10.09	No	Yes	1	7	8
1009	S:S:A168	X:X:W1	3.89	No	Yes	1	5	0
1010	S:S:I187	S:S:S170	4.64	Yes	No	0	6	7
1011	S:S:D190	S:S:S170	10.31	No	No	0	8	7
1012	S:S:S170	X:X:W1	4.94	No	Yes	0	7	0
1013	S:S:L174	S:S:S171	4.5	Yes	No	0	7	7
1014	S:S:L173	S:S:R172	6.07	Yes	No	0	5	4
1015	S:S:E191	S:S:R172	9.3	No	No	0	3	4
1016	S:S:D217	S:S:L173	4.07	Yes	Yes	0	6	5
1017	S:S:L173	S:S:P221	6.57	Yes	No	0	5	3
1018	S:S:F180	S:S:L174	7.31	Yes	Yes	3	5	7
1019	S:S:F183	S:S:L174	13.4	Yes	Yes	3	8	7
1020	S:S:L174	S:S:R185	4.86	Yes	Yes	3	7	9
1021	S:S:R185	S:S:S175	5.27	Yes	No	3	9	8
1022	S:S:C482	S:S:S175	6.89	No	No	3	7	8
1023	S:S:D484	S:S:S175	4.42	Yes	No	3	8	8
1024	S:S:N176	S:S:N178	8.17	No	No	0	6	3
1025	S:S:F183	S:S:K177	3.72	Yes	No	0	8	7
1026	S:S:F180	S:S:Q179	9.37	Yes	No	3	5	5
1027	S:S:F183	S:S:R185	6.41	Yes	Yes	3	8	9
1028	S:S:L184	S:S:L464	4.15	No	Yes	0	6	7
1029	S:S:F479	S:S:L184	10.96	Yes	No	0	8	6
1030	S:S:N189	S:S:R185	7.23	No	Yes	0	8	9
1031	S:S:D484	S:S:R185	7.15	Yes	Yes	3	8	9
1032	S:S:A423	S:S:T186	3.36	No	No	44	9	8
1033	S:S:I187	S:S:P188	5.08	Yes	Yes	1	6	8
1034	S:S:I187	S:S:L322	7.14	Yes	Yes	1	6	4
1035	S:S:I187	S:S:N419	4.25	Yes	No	0	6	7
1036	S:S:L322	S:S:P188	3.28	Yes	Yes	1	4	8
1037	S:S:P188	S:S:Y489	5.56	Yes	Yes	1	8	8
1038	S:S:E191	S:S:N189	7.89	No	No	0	3	8
1039	S:S:D190	S:S:Q193	13.05	No	Yes	0	8	9
1040	S:S:D190	S:S:Y218	5.75	No	Yes	0	8	7
1041	S:S:E191	S:S:K225	13.5	No	Yes	0	3	3
1042	S:S:H192	S:S:Y511	4.36	No	Yes	1	4	5
1043	S:S:H192	S:S:V513	11.07	No	Yes	1	4	3
1044	S:S:H192	S:S:R520	5.64	No	No	1	4	3
1045	S:S:F270	S:S:Q193	3.51	Yes	Yes	1	7	9
1046	S:S:Q193	S:S:S296	4.33	Yes	No	1	9	8
1047	S:S:E297	S:S:Q193	3.82	No	Yes	0	8	9
1048	S:S:F320	S:S:Q193	12.88	Yes	Yes	1	6	9
1049	S:S:Q193	S:S:Y489	5.64	Yes	Yes	1	9	8
1050	S:S:A194	S:S:K225	3.21	No	Yes	0	7	3
1051	S:S:D199	S:S:T195	4.34	Yes	No	0	7	4
1052	S:S:E229	S:S:T195	11.29	Yes	No	0	5	4
1053	S:S:A196	S:S:F320	4.16	No	Yes	0	8	6
1054	S:S:A196	S:S:Y511	9.34	No	Yes	0	8	5
1055	S:S:M197	S:S:V268	3.04	No	No	0	7	6
1056	S:S:F270	S:S:M197	8.71	Yes	No	0	7	7
1057	S:S:F320	S:S:M197	6.22	Yes	No	0	6	7
1058	S:S:A198	S:S:R233	4.15	No	Yes	0	7	4
1059	S:S:D199	S:S:E202	12.99	Yes	No	1	7	5
1060	S:S:D199	S:S:R233	10.72	Yes	Yes	1	7	4
1061	S:S:D199	S:S:Y511	5.75	Yes	Yes	1	7	5
1062	S:S:D199	S:S:L521	4.07	Yes	Yes	1	7	5
1063	S:S:F320	S:S:I200	3.77	Yes	No	0	6	8
1064	S:S:I200	S:S:L521	4.28	No	Yes	0	8	5
1065	S:S:I201	S:S:W206	4.7	No	Yes	1	6	9
1066	S:S:I201	S:S:V209	3.07	No	Yes	1	6	8
1067	S:S:I201	S:S:I235	5.89	No	No	1	6	7
1068	S:S:E202	S:S:R233	16.28	No	Yes	1	5	4
1069	S:S:F204	S:S:Y203	7.22	Yes	No	1	7	5
1070	S:S:L521	S:S:Y203	3.52	Yes	No	1	5	5
1071	S:S:I523	S:S:Y203	6.04	No	No	1	6	5
1072	S:S:F204	S:S:W206	11.02	Yes	Yes	1	7	9
1073	S:S:F204	S:S:I523	5.02	Yes	No	1	7	6
1074	S:S:E525	S:S:F204	4.66	Yes	Yes	1	4	7
1075	S:S:F204	S:S:W530	10.02	Yes	Yes	1	7	8
1076	S:S:V266	S:S:W206	13.48	Yes	Yes	1	7	9
1077	S:S:W206	S:S:W530	5.62	Yes	Yes	1	9	8
1078	S:S:S540	S:S:W206	7.41	No	Yes	1	9	9
1079	S:S:N207	S:S:N541	13.62	No	No	0	6	5
1080	S:S:C561	S:S:N207	11.02	Yes	No	0	9	6
1081	S:S:D238	S:S:W208	16.75	Yes	Yes	4	8	9
1082	S:S:T263	S:S:W208	4.85	No	Yes	0	5	9
1083	S:S:A264	S:S:W208	3.89	No	Yes	4	7	9
1084	S:S:C542	S:S:W208	14.37	No	Yes	4	9	9
1085	S:S:P559	S:S:W208	5.4	No	Yes	4	6	9
1086	S:S:C562	S:S:W208	5.22	No	Yes	4	9	9
1087	S:S:I235	S:S:V209	3.07	No	Yes	1	7	8
1088	S:S:I237	S:S:V209	3.07	No	Yes	0	6	8
1089	S:S:V209	S:S:V266	6.41	Yes	Yes	1	8	7
1090	S:S:F239	S:S:G210	7.53	Yes	No	0	6	8
1091	S:S:I223	S:S:T211	6.08	No	No	0	5	5
1092	S:S:I237	S:S:T211	6.08	No	No	0	6	5
1093	S:S:S240	S:S:T211	7.99	No	No	0	4	5
1094	S:S:I212	S:S:I243	5.89	No	No	0	6	5
1095	S:S:I212	S:S:V269	3.07	No	No	0	6	5
1096	S:S:A213	S:S:I223	4.87	No	No	0	4	5
1097	S:S:A214	S:S:D216	3.09	No	No	0	5	6
1098	S:S:A214	S:S:S271	3.42	No	No	0	5	4
1099	S:S:A214	S:S:D275	3.09	No	Yes	0	5	5
1100	S:S:D215	S:S:R220	7.15	No	No	0	6	6
1101	S:S:D215	S:S:L242	10.86	No	No	0	6	4
1102	S:S:D216	S:S:Y218	3.45	No	Yes	0	6	7
1103	S:S:D217	S:S:R220	3.57	Yes	No	0	6	6
1104	S:S:S296	S:S:Y218	6.36	No	Yes	1	8	7
1105	S:S:A298	S:S:Y218	4	No	Yes	1	6	7
1106	S:S:Y218	X:X:W1	15.43	Yes	Yes	1	7	0
1107	S:S:F270	S:S:G222	6.02	Yes	No	0	7	7
1108	S:S:E224	S:S:R227	15.12	No	Yes	0	6	4
1109	S:S:E228	S:S:K225	9.45	No	Yes	0	3	3
1110	S:S:E229	S:S:K225	10.8	Yes	Yes	0	5	3
1111	S:S:A230	S:S:F226	4.16	No	No	0	6	6
1112	S:S:F226	S:S:V268	10.49	No	No	0	6	6
1113	S:S:E229	S:S:E232	5.07	Yes	No	1	5	4
1114	S:S:E229	S:S:R233	9.3	Yes	Yes	1	5	4
1115	S:S:A230	S:S:I235	4.87	No	No	0	6	7
1116	S:S:E232	S:S:R233	3.49	No	Yes	1	4	4
1117	S:S:C236	S:S:C561	7.28	No	Yes	4	9	9
1118	S:S:D238	S:S:F239	4.78	Yes	Yes	4	8	6
1119	S:S:D238	S:S:S262	4.42	Yes	No	4	8	7
1120	S:S:A264	S:S:D238	3.09	No	Yes	4	7	8
1121	S:S:F239	S:S:V258	5.24	Yes	No	4	6	4
1122	S:S:F239	S:S:S262	6.61	Yes	No	4	6	7
1123	S:S:F239	S:S:I267	3.77	Yes	No	4	6	7
1124	S:S:E241	S:S:H254	4.92	No	No	4	5	3
1125	S:S:E241	S:S:V255	5.7	No	No	0	5	5
1126	S:S:E241	S:S:V258	9.98	No	No	4	5	4
1127	S:S:I243	S:S:V255	3.07	No	No	0	5	5
1128	S:S:I243	S:S:L279	4.28	No	No	0	5	5
1129	S:S:Q245	S:S:Y246	14.65	No	No	0	4	3
1130	S:S:P274	S:S:Q245	4.74	Yes	No	0	3	4
1131	S:S:D275	S:S:Q245	5.22	Yes	No	0	5	4
1132	S:S:E251	S:S:S247	10.06	No	No	0	4	2
1133	S:S:I252	S:S:S247	6.19	No	No	0	4	2
1134	S:S:D248	S:S:E251	9.09	No	No	0	3	4
1135	S:S:I252	S:S:P278	3.39	No	No	0	4	2
1136	S:S:E282	S:S:I252	5.47	No	No	0	6	4
1137	S:S:H254	S:S:V258	4.15	No	No	4	3	4
1138	S:S:I259	S:S:V255	3.07	No	No	0	6	5
1139	S:S:I283	S:S:V256	6.14	Yes	No	0	4	5
1140	S:S:R286	S:S:V256	6.54	Yes	No	0	4	5
1141	S:S:E257	S:S:R286	3.49	No	Yes	0	3	4
1142	S:S:Q260	S:S:R286	5.84	No	Yes	0	5	4
1143	S:S:K265	S:S:S540	3.06	No	No	0	5	9
1144	S:S:I292	S:S:V266	3.07	Yes	Yes	1	7	7
1145	S:S:S540	S:S:V266	6.46	No	Yes	1	9	7
1146	S:S:I267	S:S:K291	5.82	No	No	4	7	6
1147	S:S:I267	S:S:W293	9.4	No	Yes	4	7	8
1148	S:S:L294	S:S:V268	5.96	No	No	0	7	6
1149	S:S:V269	S:S:W299	9.81	No	Yes	0	5	7
1150	S:S:F270	S:S:S296	9.25	Yes	No	1	7	8
1151	S:S:L276	S:S:S271	7.51	No	No	0	5	4
1152	S:S:P274	S:S:S272	3.56	Yes	No	0	3	5
1153	S:S:D275	S:S:S272	4.42	Yes	No	0	5	5
1154	S:S:G273	S:S:P274	4.06	No	Yes	0	4	3
1155	S:S:L304	S:S:P274	3.28	No	Yes	43	2	3
1156	S:S:L276	S:S:W299	10.25	No	Yes	17	5	7
1157	S:S:I305	S:S:L276	7.14	Yes	No	17	4	5
1158	S:S:E277	S:S:K281	5.4	No	No	0	2	2
1159	S:S:E277	S:S:L304	7.95	No	No	0	2	2
1160	S:S:E277	S:S:I305	4.1	No	Yes	0	2	4
1161	S:S:I283	S:S:L279	4.28	Yes	No	0	4	5
1162	S:S:I280	S:S:I305	4.42	No	Yes	0	5	4
1163	S:S:I280	S:S:Y310	8.46	No	Yes	0	5	3
1164	S:S:I280	S:S:V314	6.14	No	No	0	5	7
1165	S:S:K281	S:S:Y310	4.78	No	Yes	0	2	3
1166	S:S:E282	S:S:R285	8.14	No	No	0	6	3
1167	S:S:I283	S:S:I288	4.42	Yes	No	0	4	4
1168	S:S:I283	S:S:V313	3.07	Yes	No	0	4	3
1169	S:S:V284	S:S:Y310	10.09	No	Yes	0	3	3
1170	S:S:V284	S:S:V313	6.41	No	No	0	3	3
1171	S:S:R285	S:S:R286	4.26	No	Yes	0	3	4
1172	S:S:N287	S:S:T289	4.39	No	No	0	6	5
1173	S:S:H312	S:S:N287	5.1	No	No	0	3	6
1174	S:S:K291	S:S:W293	3.48	No	Yes	4	6	8
1175	S:S:I292	S:S:W530	7.05	Yes	Yes	1	7	8
1176	S:S:I292	S:S:P538	5.08	Yes	No	1	7	8
1177	S:S:V314	S:S:W293	8.58	No	Yes	0	7	8
1178	S:S:T317	S:S:W293	6.06	No	Yes	0	7	8
1179	S:S:I318	S:S:L294	4.28	No	No	0	6	7
1180	S:S:A295	S:S:W299	11.67	No	Yes	0	7	7
1181	S:S:E297	S:S:L322	9.28	No	Yes	0	8	4
1182	S:S:E297	S:S:I416	5.47	No	Yes	0	8	4
1183	S:S:A298	X:X:W1	6.48	No	Yes	1	6	0
1184	S:S:I305	S:S:W299	5.87	Yes	Yes	17	4	7
1185	S:S:W299	S:S:W494	3.75	Yes	Yes	17	7	7
1186	S:S:I305	S:S:S302	4.64	Yes	No	0	4	5
1187	S:S:P407	S:S:S303	3.56	No	No	0	1	3
1188	S:S:I305	S:S:W494	3.52	Yes	Yes	17	4	7
1189	S:S:A306	S:S:W494	6.48	No	Yes	17	4	7
1190	S:S:A306	S:S:I503	4.87	No	No	17	4	4
1191	S:S:M307	S:S:P308	3.35	No	No	0	3	2
1192	S:S:M307	S:S:Q309	5.44	No	No	45	3	3
1193	S:S:M307	S:S:Y310	4.79	No	Yes	45	3	3
1194	S:S:Q309	S:S:Y310	9.02	No	Yes	45	3	3
1195	S:S:F311	S:S:G315	7.53	Yes	No	0	3	4
1196	S:S:F311	S:S:L496	20.7	Yes	No	0	3	3
1197	S:S:F311	S:S:I503	7.54	Yes	No	0	3	4
1198	S:S:H312	S:S:V313	4.15	No	No	0	3	3
1199	S:S:G316	S:S:N493	5.09	No	No	0	8	9
1200	S:S:T317	S:S:W494	12.13	No	Yes	0	7	7
1201	S:S:I318	S:S:W530	3.52	No	Yes	0	6	8
1202	S:S:F320	S:S:Y489	4.13	Yes	Yes	1	6	8
1203	S:S:A321	S:S:R415	6.91	Yes	No	0	5	5
1204	S:S:A321	S:S:I492	3.25	Yes	No	0	5	5
1205	S:S:L322	S:S:Y489	3.52	Yes	Yes	1	4	8
1206	S:S:A324	S:S:H413	5.85	No	No	0	5	7
1207	S:S:G325	S:S:Y418	10.14	No	Yes	0	4	7
1208	S:S:M473	S:S:Q326	4.08	Yes	No	0	4	3
1209	S:S:I327	S:S:P328	3.39	Yes	No	0	6	4
1210	S:S:F330	S:S:I327	6.28	Yes	Yes	1	8	6
1211	S:S:I327	S:S:Y418	3.63	Yes	Yes	1	6	7
1212	S:S:I327	S:S:Y421	9.67	Yes	Yes	1	6	8
1213	S:S:N472	S:S:P328	3.26	No	No	0	4	4
1214	S:S:F330	S:S:L334	12.18	Yes	No	0	8	6
1215	S:S:F330	S:S:L414	6.09	Yes	No	0	8	6
1216	S:S:K335	S:S:R331	12.38	No	No	0	4	4
1217	S:S:R331	S:S:Y411	13.38	No	Yes	0	4	5
1218	S:S:L334	S:S:Y408	11.72	No	Yes	0	6	3
1219	S:S:L334	S:S:Y411	4.69	No	Yes	0	6	5
1220	S:S:K335	S:S:S402	3.06	No	No	0	4	4
1221	S:S:I409	S:S:K335	14.54	No	No	0	5	4
1222	S:S:F351	S:S:V337	6.55	Yes	No	1	6	5
1223	S:S:V337	S:S:Y408	6.31	No	Yes	1	5	3
1224	S:S:H338	S:S:P339	7.63	No	No	1	4	7
1225	S:S:H338	S:S:W352	3.17	No	Yes	1	4	8
1226	S:S:P339	S:S:W352	28.38	No	Yes	1	7	8
1227	S:S:L360	S:S:P339	3.28	No	No	0	4	7
1228	S:S:A348	S:S:S342	3.42	No	No	0	5	3
1229	S:S:H344	S:S:V343	6.92	No	No	0	3	3
1230	S:S:A348	S:S:N345	4.69	No	Yes	0	5	8
1231	S:S:A348	S:S:K349	3.21	No	No	0	5	3
1232	S:S:F351	S:S:I401	6.28	Yes	No	0	6	7
1233	S:S:F351	S:S:Y408	19.6	Yes	Yes	1	6	3
1234	S:S:F356	S:S:W352	17.04	Yes	Yes	1	8	8
1235	S:S:E399	S:S:W352	5.45	No	Yes	1	8	8
1236	S:S:F356	S:S:T355	10.38	Yes	Yes	1	8	4
1237	S:S:I401	S:S:T355	4.56	No	Yes	0	7	4
1238	S:S:T355	S:S:V404	4.76	Yes	No	1	4	4
1239	S:S:T355	S:S:T406	3.14	Yes	No	1	4	4
1240	S:S:E399	S:S:F356	15.16	No	Yes	1	8	8
1241	S:S:F356	S:S:V404	3.93	Yes	No	1	8	4
1242	S:S:C358	S:S:P393	3.77	No	No	0	9	1
1243	S:S:C358	S:S:C395	7.28	No	No	0	9	9
1244	S:S:H359	S:S:Q361	13.6	No	No	0	4	1
1245	S:S:H359	S:S:R392	10.16	No	No	0	4	1
1246	S:S:C395	S:S:L360	7.94	No	No	0	9	4
1247	S:S:F391	S:S:R392	3.21	No	No	0	1	1
1248	S:S:G397	S:S:T396	3.64	No	No	0	5	6
1249	S:S:D398	S:S:T396	5.78	No	No	0	3	6
1250	S:S:E399	S:S:T396	8.47	No	No	0	8	6
1251	S:S:N400	S:S:S402	4.47	No	No	0	4	4
1252	S:S:I401	S:S:I409	4.42	No	No	0	7	5
1253	S:S:D410	S:S:E405	9.09	No	No	0	6	4
1254	S:S:P407	S:S:T406	3.5	No	No	1	1	4
1255	S:S:I409	S:S:Y408	6.04	No	Yes	0	5	3
1256	S:S:L414	S:S:Y411	8.21	No	Yes	0	6	5
1257	S:S:H413	S:S:T412	5.48	No	No	0	7	5
1258	S:S:H413	S:S:R415	13.54	No	No	0	7	5
1259	S:S:L414	S:S:S417	4.5	No	No	0	6	6
1260	S:S:R415	X:X:?2	6.99	No	Yes	0	5	0
1261	S:S:I416	X:X:?2	6.57	Yes	Yes	1	4	0
1262	S:S:S417	X:X:?2	5.18	No	Yes	1	6	0
1263	S:S:L422	S:S:Y418	7.03	No	Yes	0	8	7
1264	S:S:N471	S:S:Y418	5.81	Yes	Yes	1	6	7
1265	S:S:M473	S:S:Y418	3.59	Yes	Yes	1	4	7
1266	S:S:Y421	S:S:Y425	6.95	Yes	Yes	1	8	8
1267	S:S:L422	S:S:V477	4.47	No	No	0	8	6
1268	S:S:H429	S:S:Y425	6.53	No	Yes	1	6	8
1269	S:S:F479	S:S:S426	3.96	Yes	No	0	8	7
1270	S:S:I427	S:S:L464	4.28	Yes	Yes	0	5	7
1271	S:S:F469	S:S:H429	19.23	No	No	0	8	6
1272	S:S:A430	S:S:L464	3.15	No	Yes	0	8	7
1273	S:S:Q432	S:S:T436	5.67	No	No	0	7	4
1274	S:S:D433	S:S:H463	3.78	No	Yes	0	4	5
1275	S:S:A450	S:S:I434	4.87	No	No	0	3	6
1276	S:S:I434	S:S:V455	3.07	No	No	0	6	4
1277	S:S:H463	S:S:I434	14.58	Yes	No	0	5	6
1278	S:S:T436	S:S:Y435	4.99	No	No	0	4	3
1279	S:S:I452	S:S:Y435	4.84	No	No	0	3	3
1280	S:S:C437	S:S:C449	7.28	No	No	46	6	7
1281	S:S:K462	S:S:L443	15.51	Yes	No	10	4	3
1282	S:S:H463	S:S:L443	6.43	Yes	No	0	5	3
1283	S:S:H466	S:S:L443	3.86	No	No	10	4	3
1284	S:S:A450	S:S:F444	4.16	No	Yes	10	3	3
1285	S:S:F444	S:S:W458	5.01	Yes	Yes	10	3	4
1286	S:S:F444	S:S:Q459	4.68	Yes	Yes	10	3	7
1287	S:S:F444	S:S:K462	3.72	Yes	Yes	10	3	4
1288	S:S:F444	S:S:H463	4.53	Yes	Yes	0	3	5
1289	S:S:N446	S:S:T445	5.85	No	Yes	0	3	1
1290	S:S:A450	S:S:Q459	7.58	No	Yes	10	3	7
1291	S:S:I452	S:S:K453	4.36	No	No	0	3	2
1292	S:S:I452	S:S:V455	4.61	No	No	0	3	4
1293	S:S:E456	S:S:K454	8.1	Yes	No	0	5	3
1294	S:S:Q459	S:S:V455	4.3	Yes	No	0	7	4
1295	S:S:E456	S:S:W458	7.63	Yes	Yes	10	5	4
1296	S:S:E456	S:S:Q459	8.92	Yes	Yes	10	5	7
1297	S:S:Q459	S:S:W458	16.43	Yes	Yes	10	7	4
1298	S:S:H466	S:S:K462	5.24	No	Yes	10	4	4
1299	S:S:F469	S:S:L467	3.65	No	No	0	8	7
1300	S:S:N468	S:S:Q476	6.6	No	No	0	6	3
1301	S:S:N468	S:S:T478	5.85	No	No	0	6	3
1302	S:S:F469	S:S:V477	9.18	No	No	0	8	6
1303	S:S:Q476	S:S:T470	5.67	No	No	0	3	5
1304	S:S:M473	S:S:N471	7.01	Yes	Yes	1	4	6
1305	S:S:G474	S:S:N471	3.39	No	Yes	0	5	6
1306	S:S:E475	S:S:N471	10.52	No	Yes	1	5	6
1307	S:S:M473	S:S:N472	5.61	Yes	No	0	4	4
1308	S:S:E475	S:S:M473	5.41	No	Yes	1	5	4
1309	S:S:F479	S:S:L485	7.31	Yes	No	0	8	4
1310	S:S:D480	S:S:D484	3.99	No	Yes	0	7	8
1311	S:S:C482	S:S:D484	3.11	No	Yes	3	7	8
1312	S:S:V486	S:S:V513	3.21	No	Yes	0	3	3
1313	S:S:N488	S:S:N512	5.45	No	Yes	1	4	4
1314	S:S:N488	S:S:V513	4.43	No	Yes	1	4	3
1315	S:S:N488	S:S:Y514	9.3	No	No	1	4	4
1316	S:S:Y489	S:S:Y511	3.97	Yes	Yes	1	8	5
1317	S:S:I491	S:S:V508	3.07	No	No	0	8	7
1318	S:S:G509	S:S:I491	5.29	No	No	0	9	8
1319	S:S:F505	S:S:I492	7.54	No	No	0	4	5
1320	S:S:H495	S:S:N493	10.2	No	No	0	7	9
1321	S:S:I528	S:S:N493	4.25	Yes	No	0	7	9
1322	S:S:I503	S:S:W494	4.7	No	Yes	17	4	7
1323	S:S:F505	S:S:W494	12.03	No	Yes	0	4	7
1324	S:S:H495	S:S:K506	7.86	No	No	0	7	5
1325	S:S:H495	S:S:L529	12.86	No	No	0	7	4
1326	S:S:P498	S:S:S497	3.56	No	Yes	0	3	3
1327	S:S:D500	S:S:S497	5.89	No	Yes	0	4	3
1328	S:S:S497	S:S:S502	3.26	Yes	No	0	3	4
1329	S:S:S497	S:S:V504	3.23	Yes	No	0	3	3
1330	S:S:K506	S:S:V504	3.04	No	No	0	5	3
1331	S:S:I528	S:S:V508	9.22	Yes	No	0	7	7
1332	S:S:F522	S:S:Y510	14.44	No	No	0	1	3
1333	S:S:R520	S:S:Y511	13.38	No	Yes	1	3	5
1334	S:S:L521	S:S:Y511	3.52	Yes	Yes	1	5	5
1335	S:S:N512	S:S:Y514	5.81	Yes	No	1	4	4
1336	S:S:A515	S:S:N512	4.69	No	Yes	0	4	4
1337	S:S:V513	S:S:Y514	7.57	Yes	No	1	3	4
1338	S:S:I523	S:S:L521	8.56	No	Yes	1	6	5
1339	S:S:K527	S:S:N524	9.79	No	No	0	3	5
1340	S:S:E525	S:S:E526	3.81	Yes	No	0	4	3
1341	S:S:E525	S:S:I528	6.83	Yes	Yes	1	4	7
1342	S:S:E525	S:S:W530	8.72	Yes	Yes	1	4	8
1343	S:S:E525	S:S:V537	4.28	Yes	No	1	4	4
1344	S:S:E526	S:S:R535	5.82	No	No	0	3	4
1345	S:S:I528	S:S:W530	5.87	Yes	Yes	1	7	8
1346	S:S:V537	S:S:W530	12.26	No	Yes	1	4	8
1347	S:S:P538	S:S:W530	18.92	No	Yes	1	8	8
1348	S:S:F533	S:S:S531	5.28	No	No	0	1	4
1349	S:S:E536	S:S:S534	5.75	No	No	0	5	4
1350	S:S:P538	S:S:V537	3.53	No	No	1	8	4
1351	S:S:F539	S:S:N541	8.46	No	No	0	1	5
1352	S:S:C542	S:S:C562	7.28	No	No	4	9	9
1353	S:S:R544	S:S:S543	7.91	No	No	0	5	8
1354	S:S:F563	S:S:S543	7.93	Yes	No	0	7	8
1355	S:S:D545	S:S:T577	4.34	No	No	0	5	5
1356	S:S:D545	S:S:D578	13.31	No	No	18	5	7
1357	S:S:C546	S:S:T550	6.76	No	Yes	18	9	6
1358	S:S:C546	S:S:F563	4.19	No	Yes	18	9	7
1359	S:S:C546	S:S:C565	7.28	No	No	18	9	9
1360	S:S:C565	S:S:T550	6.76	No	Yes	18	9	6
1361	S:S:E567	S:S:T550	5.64	No	Yes	0	4	6
1362	S:S:R551	S:S:V566	13.08	No	No	0	7	4
1363	S:S:C582	S:S:R551	4.18	No	No	0	9	7
1364	S:S:F563	S:S:K552	22.33	Yes	No	0	7	8
1365	S:S:E558	S:S:I555	5.47	No	No	0	5	5
1366	S:S:E564	S:S:I555	8.2	No	No	0	6	5
1367	S:S:E558	S:S:P559	6.29	No	No	0	5	6
1368	S:S:C562	S:S:P559	3.77	No	No	4	9	6
1369	S:S:E567	S:S:H595	7.39	No	Yes	0	4	5
1370	S:S:C568	S:S:S574	3.44	No	No	0	9	8
1371	S:S:C568	S:S:C582	7.28	No	No	0	9	9
1372	S:S:E572	S:S:P569	7.86	No	No	0	7	5
1373	S:S:D570	S:S:H595	11.35	No	Yes	0	5	5
1374	S:S:G571	S:S:W590	9.85	No	No	0	7	6
1375	S:S:G571	S:S:S591	3.71	No	No	0	7	8
1376	S:S:E572	S:S:K584	8.1	No	No	0	7	4
1377	S:S:D575	S:S:Y573	4.6	No	No	0	8	6
1378	S:S:N583	S:S:Y573	12.79	No	No	0	1	6
1379	S:S:C585	S:S:Y573	5.38	Yes	No	0	9	6
1380	S:S:C585	S:S:P586	3.77	Yes	No	0	9	4
1381	S:S:C585	S:S:C598	5.46	Yes	No	0	9	9
1382	S:S:F589	S:S:P586	10.11	No	No	0	5	4
1383	S:S:D587	S:S:D588	10.65	No	Yes	0	3	6
1384	S:S:D588	S:S:R752	7.15	Yes	No	21	6	3
1385	S:S:D588	S:S:Q754	3.92	Yes	No	21	6	4
1386	S:S:D588	S:S:I761	7	Yes	Yes	21	6	7
1387	S:S:E759	S:S:W590	13.08	No	No	0	4	6
1388	S:S:H595	S:S:S591	5.58	Yes	No	0	5	8
1389	S:S:N592	S:S:S597	8.94	No	No	0	7	1
1390	S:S:I599	S:S:N592	14.16	No	No	0	4	7
1391	S:S:S597	S:S:T596	3.2	No	No	0	1	5
1392	S:S:K601	S:S:Q754	6.78	No	No	21	8	4
1393	S:S:I761	S:S:K601	8.72	Yes	No	21	7	8
1394	S:S:I603	S:S:I761	5.89	No	Yes	0	4	7
1395	S:S:I603	S:S:I763	7.36	No	No	0	4	7
1396	S:S:E604	S:S:F762	4.66	No	Yes	0	6	7
1397	S:S:E604	S:S:K831	9.45	No	No	0	6	9
1398	S:S:F605	S:S:S607	9.25	No	No	0	7	7
1399	S:S:E671	S:S:F605	10.49	No	No	0	4	7
1400	S:S:F605	S:S:P672	5.78	No	No	0	7	9
1401	S:S:E610	S:S:L606	3.98	No	No	0	7	9
1402	S:S:E610	S:S:S607	5.75	No	No	0	7	7
1403	S:S:T617	S:S:W608	7.28	No	Yes	0	5	5
1404	S:S:I669	S:S:W608	4.7	Yes	Yes	0	8	5
1405	S:S:G670	S:S:W608	4.22	No	Yes	0	7	5
1406	S:S:F612	S:S:F832	11.79	No	Yes	0	8	5
1407	S:S:A835	S:S:F612	4.16	No	No	0	8	8
1408	S:S:L616	S:S:V838	7.45	No	No	0	8	7
1409	S:S:A620	S:S:L666	3.15	No	No	0	7	7
1410	S:S:F662	S:S:G623	7.53	Yes	No	0	8	6
1411	S:S:L659	S:S:T627	4.42	No	No	0	4	7
1412	S:S:F662	S:S:T627	6.49	Yes	No	0	8	7
1413	S:S:L849	S:S:T627	5.9	No	No	0	8	7
1414	S:S:F629	S:S:V633	5.24	No	No	0	3	5
1415	S:S:L655	S:S:V630	4.47	No	No	47	9	7
1416	S:S:F853	S:S:V630	5.24	Yes	No	47	9	7
1417	S:S:I857	S:S:V630	6.14	No	No	0	8	7
1418	S:S:I635	S:S:L631	5.71	No	No	0	4	4
1419	S:S:L631	S:S:L655	13.84	No	No	0	4	9
1420	S:S:I857	S:S:V633	3.07	No	No	0	8	5
1421	S:S:F634	S:S:V643	10.49	No	No	0	9	9
1422	S:S:F634	S:S:S651	7.93	No	No	0	9	9
1423	S:S:F634	S:S:K856	4.96	No	No	0	9	9
1424	S:S:F637	S:S:T640	16.86	No	Yes	0	4	9
1425	S:S:F637	S:S:I860	5.02	No	No	0	4	9
1426	S:S:N639	S:S:R638	7.23	No	No	0	4	6
1427	S:S:R638	S:S:R648	4.26	No	No	0	6	8
1428	S:S:P641	S:S:T640	3.5	No	Yes	0	8	9
1429	S:S:I642	S:S:T640	3.04	Yes	Yes	48	7	9
1430	S:S:T640	S:S:T868	4.71	Yes	No	48	9	6
1431	S:S:K644	S:S:P641	3.35	No	No	0	8	8
1432	S:S:E870	S:S:P641	6.29	No	No	0	7	8
1433	S:S:I642	S:S:V643	3.07	Yes	No	0	7	9
1434	S:S:I642	S:S:I860	8.83	Yes	No	0	7	9
1435	S:S:I642	S:S:T868	4.56	Yes	No	48	7	6
1436	S:S:K644	S:S:R648	8.66	No	No	0	8	8
1437	S:S:N700	S:S:T646	5.85	No	Yes	0	7	9
1438	S:S:N800	S:S:T646	7.31	Yes	Yes	49	7	9
1439	S:S:E803	S:S:T646	7.06	No	Yes	49	9	9
1440	S:S:L650	S:S:N647	10.98	No	No	0	8	9
1441	S:S:N647	S:S:Q724	5.28	No	Yes	0	9	8
1442	S:S:R648	S:S:Y652	4.12	No	No	0	8	7
1443	S:S:C694	S:S:L650	4.76	No	No	0	6	8
1444	S:S:K698	S:S:L650	7.05	No	No	0	9	8
1445	S:S:L653	S:S:L690	4.15	No	No	0	5	7
1446	S:S:C694	S:S:L653	3.17	No	No	0	6	5
1447	S:S:C691	S:S:L654	4.76	Yes	Yes	0	8	8
1448	S:S:C694	S:S:L654	7.94	No	Yes	0	6	8
1449	S:S:I695	S:S:L654	5.71	No	Yes	0	7	8
1450	S:S:F853	S:S:L654	6.09	Yes	Yes	0	9	8
1451	S:S:F853	S:S:L655	8.53	Yes	No	47	9	9
1452	S:S:C660	S:S:F656	5.59	No	No	0	7	4
1453	S:S:L690	S:S:S657	9.01	No	No	0	7	9
1454	S:S:C691	S:S:S657	6.89	Yes	No	0	8	9
1455	S:S:C691	S:S:L658	3.17	Yes	No	0	8	8
1456	S:S:L658	S:S:L849	4.15	No	No	0	8	8
1457	S:S:C660	S:S:S687	5.16	No	No	0	7	6
1458	S:S:C661	S:S:S687	5.16	No	No	0	7	6
1459	S:S:C661	S:S:S845	3.44	No	No	0	7	8
1460	S:S:F662	S:S:S845	10.57	Yes	No	0	8	8
1461	S:S:F662	S:S:F846	5.36	Yes	No	0	8	6
1462	S:S:F684	S:S:S664	5.28	Yes	No	0	8	6
1463	S:S:S665	S:S:V838	3.23	No	No	0	8	7
1464	S:S:F667	S:S:L679	7.31	No	No	0	5	5
1465	S:S:F668	S:S:R680	13.9	Yes	Yes	0	9	8
1466	S:S:E837	S:S:F668	10.49	No	Yes	0	9	9
1467	S:S:F668	S:S:V838	3.93	Yes	No	0	9	7
1468	S:S:F668	S:S:I841	3.77	Yes	No	0	9	9
1469	S:S:E671	S:S:Q673	5.1	No	No	0	4	4
1470	S:S:I763	S:S:P672	8.47	No	No	0	7	9
1471	S:S:Q673	S:S:W675	17.52	No	No	0	4	3
1472	S:S:D674	S:S:R678	11.91	No	Yes	0	3	5
1473	S:S:T676	S:S:W675	7.28	No	No	0	7	3
1474	S:S:R680	S:S:T676	3.88	Yes	No	0	8	7
1475	S:S:C677	S:S:S750	3.44	No	No	0	9	6
1476	S:S:C677	S:S:C765	7.28	No	No	0	9	9
1477	S:S:P747	S:S:R678	7.21	No	Yes	0	8	5
1478	S:S:P748	S:S:R678	7.21	No	Yes	0	9	5
1479	S:S:A683	S:S:L679	3.15	No	No	0	5	5
1480	S:S:Q681	S:S:R680	7.01	No	Yes	0	9	8
1481	S:S:C765	S:S:R680	6.96	No	Yes	0	9	8
1482	S:S:L773	S:S:Q681	5.32	No	No	0	8	9
1483	S:S:Q681	X:X:?4	7.77	No	Yes	0	9	0
1484	S:S:C739	S:S:P682	3.77	No	No	0	7	5
1485	S:S:P682	S:S:W742	4.05	No	Yes	0	5	9
1486	S:S:F684	S:S:F688	10.72	Yes	Yes	0	8	8
1487	S:S:F684	S:S:W818	6.01	Yes	Yes	11	8	9
1488	S:S:F684	S:S:I841	15.07	Yes	No	0	8	9
1489	S:S:F684	X:X:?4	19.55	Yes	Yes	11	8	0
1490	S:S:G685	S:S:Q735	4.93	No	Yes	0	8	9
1491	S:S:I686	S:S:Q735	4.12	No	Yes	0	7	9
1492	S:S:F688	S:S:I692	8.79	Yes	No	0	8	7
1493	S:S:F688	S:S:F814	7.5	Yes	Yes	0	8	9
1494	S:S:F688	S:S:L848	3.65	Yes	No	0	8	7
1495	S:S:T732	S:S:V689	4.76	No	Yes	0	7	7
1496	S:S:Q735	S:S:V689	17.19	Yes	Yes	0	9	7
1497	S:S:T780	S:S:V689	3.17	No	Yes	0	7	7
1498	S:S:L690	S:S:T732	5.9	No	No	0	7	7
1499	S:S:C691	S:S:L848	6.35	Yes	No	0	8	7
1500	S:S:A784	S:S:I692	3.25	No	No	0	8	7
1501	S:S:C787	S:S:I692	3.27	No	No	0	8	7
1502	S:S:S693	S:S:V728	3.23	No	No	0	9	7
1503	S:S:I695	S:S:L848	4.28	No	No	0	7	7
1504	S:S:C787	S:S:L696	6.35	No	No	0	8	8
1505	S:S:F790	S:S:L696	3.65	Yes	No	0	7	8
1506	S:S:Q724	S:S:V697	5.73	Yes	No	0	8	8
1507	S:S:V697	S:S:V728	3.21	No	No	0	8	7
1508	S:S:R701	S:S:T699	7.76	No	No	0	8	9
1509	S:S:T699	S:S:V702	6.35	No	No	0	9	9
1510	S:S:R701	S:S:S794	3.95	No	No	0	8	9
1511	S:S:E799	S:S:R701	3.49	No	No	0	8	8
1512	S:S:V702	S:S:V705	3.21	No	No	0	9	9
1513	S:S:L703	S:S:Q724	10.65	No	Yes	0	7	8
1514	S:S:K717	S:S:W719	13.92	No	No	0	6	6
1515	S:S:L723	S:S:W719	4.56	No	No	0	7	6
1516	S:S:L726	S:S:N722	6.87	No	No	0	4	3
1517	S:S:L723	S:S:Q724	6.65	No	Yes	0	7	8
1518	S:S:I736	S:S:T732	3.04	No	No	0	5	7
1519	S:S:F733	S:S:V737	9.18	No	No	0	4	3
1520	S:S:M734	S:S:Y779	7.18	No	No	0	4	9
1521	S:S:L776	S:S:Q735	5.32	No	Yes	0	8	9
1522	S:S:Q735	S:S:Y779	4.51	Yes	No	0	9	9
1523	S:S:F775	S:S:I738	6.28	No	No	0	4	8
1524	S:S:P748	S:S:W742	9.46	No	Yes	0	9	9
1525	S:S:E767	S:S:W742	3.27	No	Yes	0	7	9
1526	S:S:S769	S:S:W742	4.94	No	Yes	0	9	9
1527	S:S:A772	S:S:W742	5.19	No	Yes	0	6	9
1528	S:S:A746	S:S:S769	3.42	No	No	0	6	9
1529	S:S:N753	S:S:Y751	10.47	No	No	0	7	3
1530	S:S:H766	S:S:Y751	6.53	Yes	No	0	6	3
1531	S:S:I761	S:S:R752	7.52	Yes	No	21	7	3
1532	S:S:E755	S:S:N753	6.57	No	No	0	4	7
1533	S:S:I761	S:S:Q754	5.49	Yes	No	21	7	4
1534	S:S:F762	S:S:L756	4.87	Yes	No	0	7	5
1535	S:S:E757	S:S:E759	6.34	No	No	0	4	4
1536	S:S:E757	S:S:I760	5.47	No	No	0	4	5
1537	S:S:D758	S:S:E759	3.9	No	No	0	4	4
1538	S:S:F762	S:S:I760	6.28	Yes	No	0	7	5
1539	S:S:F762	S:S:G830	4.52	Yes	No	0	7	8
1540	S:S:G768	S:S:H766	3.18	No	Yes	0	7	6
1541	S:S:E767	S:S:L770	7.95	No	No	0	7	3
1542	S:S:L770	X:X:?4	6.06	No	Yes	0	3	0
1543	S:S:L773	S:S:L776	4.15	No	No	0	8	8
1544	S:S:I777	X:X:?4	18.75	No	Yes	0	8	0
1545	S:S:T780	X:X:?4	6.45	No	Yes	0	7	0
1546	S:S:A784	S:S:F814	4.16	No	Yes	0	8	9
1547	S:S:C787	S:S:M811	3.24	No	No	0	8	9
1548	S:S:F788	S:S:T808	3.89	No	No	0	8	9
1549	S:S:F788	S:S:M811	4.98	No	No	0	8	9
1550	S:S:F789	S:S:F790	5.36	No	Yes	0	4	7
1551	S:S:F789	S:S:K793	3.72	No	No	0	4	7
1552	S:S:A791	S:S:I807	3.25	No	No	0	9	9
1553	S:S:F792	S:S:R795	16.03	No	No	0	8	9
1554	S:S:L797	S:S:S794	4.5	No	No	0	8	9
1555	S:S:K796	S:S:R795	4.95	No	No	0	7	9
1556	S:S:N802	S:S:P798	4.89	No	No	0	9	9
1557	S:S:F801	S:S:N800	4.83	No	Yes	0	9	7
1558	S:S:E803	S:S:N800	5.26	No	Yes	49	9	7
1559	S:S:K856	S:S:N800	9.79	No	Yes	0	9	7
1560	S:S:F801	S:S:I859	8.79	No	No	0	9	9
1561	S:S:K805	S:S:N802	6.99	Yes	No	0	9	9
1562	S:S:F806	S:S:K805	4.96	Yes	Yes	23	5	9
1563	S:S:F809	S:S:K805	8.69	Yes	Yes	23	9	9
1564	S:S:F806	S:S:F809	3.22	Yes	Yes	23	5	9
1565	S:S:C851	S:S:F806	4.19	No	Yes	0	8	5
1566	S:S:F806	S:S:N855	15.71	Yes	No	0	5	9
1567	S:S:I807	S:S:I852	4.42	No	No	0	9	9
1568	S:S:M811	S:S:S810	4.6	No	No	0	9	9
1569	S:S:C851	S:S:S810	3.44	No	No	0	8	9
1570	S:S:I852	S:S:S810	3.1	No	No	0	9	9
1571	S:S:G847	S:S:I813	3.53	No	No	0	8	8
1572	S:S:F814	S:S:F815	11.79	Yes	No	0	9	7
1573	S:S:F814	S:S:W818	7.02	Yes	Yes	0	9	9
1574	S:S:A843	S:S:V817	5.09	No	No	0	7	9
1575	S:S:F821	S:S:W818	12.03	Yes	Yes	11	9	9
1576	S:S:A840	S:S:W818	7.78	No	Yes	11	9	9
1577	S:S:W818	X:X:?4	18.29	Yes	Yes	11	9	0
1578	S:S:F821	S:S:Y825	11.35	Yes	Yes	11	9	9
1579	S:S:F821	S:S:V836	3.93	Yes	No	0	9	8
1580	S:S:A840	S:S:F821	4.16	No	Yes	11	9	9
1581	S:S:I822	S:S:P823	3.39	No	No	0	7	9
1582	S:S:V833	S:S:Y825	5.05	No	Yes	0	6	9
1583	S:S:E837	S:S:Y825	5.61	No	Yes	11	9	9
1584	S:S:Y825	X:X:?4	10.27	Yes	Yes	11	9	0
1585	S:S:T828	S:S:V833	6.35	No	No	0	8	6
1586	S:S:F832	S:S:K831	12.41	Yes	No	0	5	9
1587	S:S:E837	X:X:?4	6.77	No	Yes	11	9	0
1588	S:S:A850	S:S:F854	6.93	No	No	0	1	4
1589	S:S:F853	S:S:I852	5.02	Yes	No	0	9	9
1590	S:S:F862	S:S:Y858	10.32	No	No	0	5	8
1591	S:S:I859	S:S:N867	5.66	No	No	0	9	9
1592	S:S:F862	S:S:L861	6.09	No	No	0	5	5
1593	S:S:K863	S:S:P864	3.35	No	No	0	7	8
1594	S:S:E871	S:S:I869	5.47	No	No	0	5	6
1595	S:S:E871	S:S:V872	4.28	No	No	0	5	4
1596	R:R:A154	R:R:Q164	3.03	No	Yes	0	7	8
1597	S:S:A154	S:S:Q164	3.03	No	Yes	0	7	8
1598	R:R:P85	W:W:?3	3.02	No	No	0	3	0
1599	S:S:P85	X:X:?3	3.02	No	No	0	3	0
1600	S:S:P89	X:X:?3	3.02	No	No	0	8	0
1601	R:R:F605	R:R:G670	3.01	No	No	0	7	7
1602	R:R:F684	R:R:G685	3.01	Yes	No	0	8	8
1603	S:S:F311	S:S:G532	3.01	Yes	No	0	3	1
1604	R:R:L125	S:S:S132	3	No	No	0	4	4
1605	R:R:L464	R:R:S426	3	Yes	No	0	7	7
1606	R:R:L467	R:R:S426	3	No	No	0	7	7
1607	R:R:R678	R:R:W675	3	Yes	No	0	5	3
1608	S:S:L461	S:S:S182	3	No	No	0	7	7
1609	S:S:L606	S:S:S834	3	No	No	0	9	8
1610	S:S:K698	S:S:T646	3	No	Yes	0	9	9
1611	S:S:L842	S:S:S665	3	No	No	0	9	8
1612	R:R:N345	R:R:S342	2.98	Yes	No	0	8	3
1613	R:R:L861	R:R:V633	2.98	No	No	0	5	5
1614	R:R:L727	R:R:V697	2.98	No	No	0	7	8
1615	S:S:L861	S:S:V633	2.98	No	No	0	5	5
1616	S:S:L783	S:S:V689	2.98	No	Yes	0	9	7
1617	S:S:L727	S:S:V697	2.98	No	No	0	7	8
1618	R:R:C568	R:R:H595	2.95	No	No	0	9	5
1619	S:S:L547	S:S:T550	2.95	No	Yes	0	1	6
1620	S:S:C568	S:S:H595	2.95	No	Yes	0	9	5
1621	S:S:L666	S:S:T617	2.95	No	No	0	7	5
1622	R:R:I318	R:R:I528	2.94	No	No	0	6	7
1623	R:R:I554	S:S:I554	2.94	No	No	0	3	3
1624	R:R:I603	R:R:I761	2.94	No	No	0	4	7
1625	R:R:I642	R:R:I859	2.94	No	No	0	7	9
1626	S:S:D275	S:S:S244	2.94	Yes	No	0	5	4
1627	S:S:I738	S:S:M734	2.92	No	No	0	8	4
1628	S:S:G219	S:S:Y218	2.9	No	Yes	0	7	7
1629	R:R:D545	R:R:T577	2.89	No	No	0	5	5
1630	R:R:E109	S:S:S122	2.87	Yes	No	0	5	3
1631	R:R:E251	R:R:S247	2.87	No	No	0	4	2
1632	R:R:K516	R:R:K517	2.87	No	No	0	2	1
1633	R:R:L812	S:S:I813	2.85	No	No	0	9	8
1634	S:S:I669	S:S:L606	2.85	Yes	No	0	8	9
1635	S:S:I669	S:S:L616	2.85	Yes	No	0	8	8
1636	S:S:I786	S:S:L782	2.85	No	No	0	4	4
1637	R:R:I318	R:R:N493	2.83	No	No	0	6	9
1638	R:R:K793	R:R:L703	2.82	No	No	0	7	7
1639	R:R:R415	W:W:?2	2.8	No	Yes	0	5	0
1640	R:R:C546	R:R:F563	2.79	No	Yes	15	9	7
1641	R:R:C582	R:R:R551	2.79	No	No	0	9	7
1642	R:R:H595	R:R:S591	2.79	No	No	0	5	8
1643	S:S:H134	S:S:S132	2.79	No	No	0	4	4
1644	S:S:H766	S:S:S749	2.79	Yes	No	0	6	5
1645	S:S:P864	S:S:Y858	2.78	No	No	0	8	8
1646	R:R:L159	S:S:L108	2.77	No	No	0	5	4
1647	R:R:A835	R:R:F612	2.77	No	No	0	8	8
1648	R:R:A645	R:R:F801	2.77	No	Yes	0	9	9
1649	R:R:L703	R:R:L797	2.77	No	Yes	0	7	8
1650	R:R:A844	R:R:F814	2.77	No	Yes	0	9	9
1651	R:R:A840	R:R:F821	2.77	No	Yes	0	9	9
1652	R:R:A850	R:R:F846	2.77	No	No	0	1	6
1653	S:S:A600	S:S:F589	2.77	No	No	0	4	5
1654	S:S:L622	S:S:L626	2.77	No	No	0	3	4
1655	S:S:A844	S:S:F688	2.77	No	Yes	0	9	8
1656	S:S:A785	S:S:F815	2.77	No	No	0	2	7
1657	R:R:L797	R:R:N802	2.75	Yes	No	0	8	9
1658	S:S:L721	S:S:N722	2.75	No	No	0	6	3
1659	R:R:I686	R:R:Q735	2.74	No	Yes	0	7	9
1660	R:R:E564	R:R:I555	2.73	No	No	0	6	5
1661	S:S:E602	S:S:I760	2.73	No	No	0	3	5
1662	S:S:E507	S:S:K527	2.7	No	No	0	5	3
1663	R:R:D545	R:R:N541	2.69	No	No	0	5	5
1664	R:R:D575	R:R:N583	2.69	No	No	0	8	1
1665	R:R:L87	R:R:Q432	2.66	No	Yes	0	6	7
1666	R:R:L88	R:R:Q432	2.66	No	Yes	0	9	7
1667	R:R:L394	R:R:Q361	2.66	No	No	0	1	1
1668	R:R:E767	R:R:L770	2.65	No	No	0	7	3
1669	S:S:E353	S:S:L360	2.65	No	No	0	7	4
1670	R:R:S240	S:S:R227	2.64	No	Yes	0	4	4
1671	R:R:F533	R:R:S534	2.64	No	No	0	1	4
1672	S:S:N261	S:S:Q260	2.64	No	No	0	4	5
1673	S:S:F444	S:S:S448	2.64	Yes	No	0	3	3
1674	S:S:F533	S:S:S534	2.64	No	No	0	1	4
1675	S:S:E526	S:S:N524	2.63	No	No	0	3	5
1676	R:R:F629	R:R:V630	2.62	No	Yes	0	3	7
1677	R:R:F629	R:R:V633	2.62	No	No	0	3	5
1678	R:R:F668	R:R:V838	2.62	Yes	Yes	0	9	7
1679	R:R:F821	R:R:V817	2.62	Yes	No	0	9	9
1680	S:S:F790	S:S:V702	2.62	Yes	No	0	7	9
1681	S:S:D23	S:S:Q24	2.61	No	No	0	1	5
1682	S:S:C236	S:S:W208	2.61	No	Yes	4	9	9
1683	S:S:C561	S:S:W208	2.61	Yes	Yes	4	9	9
1684	S:S:D575	S:S:E576	2.6	No	No	0	8	3
1685	R:R:F790	R:R:T699	2.59	Yes	No	0	7	9
1686	R:R:E257	R:R:Q253	2.55	No	No	0	3	3
1687	S:S:E257	S:S:Q253	2.55	No	No	0	3	3
1688	R:R:F637	R:R:I860	2.51	No	No	0	4	9
1689	S:S:F790	S:S:I786	2.51	Yes	No	0	7	4
1690	S:S:T764	S:S:Y751	2.5	No	No	0	7	3
1691	R:R:K644	R:R:R648	2.48	No	Yes	0	8	8
1692	S:S:K517	S:S:R520	2.48	No	No	0	1	3
1693	S:S:E767	S:S:H766	2.46	No	Yes	0	7	6
1694	I:I:?2	S:S:E558	2.44	No	No	0	0	5
1695	R:R:F479	R:R:L485	2.44	No	No	0	8	4
1696	R:R:F612	R:R:L616	2.44	No	No	0	8	8
1697	R:R:F667	R:R:L679	2.44	No	No	0	5	5
1698	R:R:F729	R:R:L690	2.44	No	No	0	3	7
1699	S:S:F846	S:S:L622	2.44	No	No	0	6	3
1700	S:S:F854	S:S:L849	2.44	No	No	0	4	8
1701	R:R:T263	R:R:W208	2.43	No	Yes	0	5	9
1702	S:S:L743	S:S:R678	2.43	No	Yes	0	7	5
1703	R:R:F522	R:R:N524	2.42	No	No	0	1	5
1704	R:R:F762	R:R:N753	2.42	Yes	Yes	0	7	7
1705	R:R:F801	R:R:N800	2.42	Yes	No	0	9	7
1706	R:R:K863	R:R:Y858	2.39	No	No	0	7	8
1707	R:R:N512	R:R:Y510	2.33	Yes	No	0	4	3
1708	R:R:E803	R:R:F806	2.33	No	No	0	9	5
1709	S:S:E231	S:S:R227	2.33	No	Yes	0	4	4
1710	S:S:E332	S:S:R331	2.33	No	No	0	5	4
1711	S:S:N512	S:S:Y510	2.33	Yes	No	0	4	3
1712	S:S:H338	S:S:R340	2.26	No	No	0	4	4
1713	R:R:H766	R:R:Y751	2.18	No	Yes	0	6	3
1714	R:R:F625	R:R:F629	2.14	No	No	0	3	3
1715	R:R:F789	R:R:F790	2.14	No	Yes	0	4	7
1716	S:S:F667	S:S:R680	2.14	No	Yes	0	5	8
1717	S:S:F725	S:S:F729	2.14	No	No	0	5	3
1718	R:R:G30	R:R:G94	2.11	No	No	0	9	9
1719	R:R:G440	R:R:G447	2.11	No	No	0	3	1
1720	R:R:G442	R:R:G447	2.11	No	No	0	4	1
1721	S:S:G30	S:S:G94	2.11	No	No	0	9	9
1722	S:S:G440	S:S:G447	2.11	No	No	0	3	1
1723	S:S:G442	S:S:G447	2.11	No	No	0	4	1
1724	R:R:F832	S:S:Y829	2.06	No	No	0	5	6
1725	R:R:G487	R:R:P188	2.03	No	No	0	6	8
1726	R:R:G329	R:R:P328	2.03	No	No	0	5	4
1727	S:S:G487	S:S:P188	2.03	No	Yes	0	6	8
1728	S:S:G329	S:S:P328	2.03	No	No	0	5	4
1729	R:R:C437	R:R:G442	1.96	No	No	33	6	4
1730	R:R:C449	R:R:G442	1.96	No	No	33	7	4
1731	S:S:C437	S:S:G442	1.96	No	No	46	6	4
1732	S:S:C449	S:S:G442	1.96	No	No	46	7	4
1733	S:S:C781	S:S:G778	1.96	No	No	0	7	5
1734	R:R:A295	R:R:G319	1.95	No	No	0	7	8
1735	R:R:A300	R:R:G319	1.95	No	No	0	6	8
1736	S:S:A295	S:S:G319	1.95	No	No	0	7	8
1737	S:S:A300	S:S:G319	1.95	No	No	0	6	8
1738	S:S:A548	S:S:G549	1.95	No	No	0	4	9
1739	S:S:A457	S:S:P163	1.87	No	Yes	0	4	8
1740	R:R:G148	R:R:S147	1.86	No	No	0	4	8
1741	R:R:G501	R:R:S497	1.86	No	Yes	0	5	3
1742	S:S:G501	S:S:S497	1.86	No	Yes	0	5	3
1743	S:S:G549	S:S:S574	1.86	No	No	0	9	8
1744	R:R:G30	R:R:T92	1.82	No	No	0	9	7
1745	R:R:G474	R:R:T470	1.82	No	No	0	5	5
1746	S:S:G30	S:S:T92	1.82	No	No	0	9	7
1747	S:S:G35	S:S:T138	1.82	No	No	0	8	6
1748	S:S:G290	S:S:T289	1.82	No	No	0	4	5
1749	S:S:G474	S:S:T470	1.82	No	No	0	5	5
1750	S:S:G549	S:S:T596	1.82	No	No	0	9	5
1751	R:R:A791	R:R:A804	1.79	No	No	0	9	9
1752	R:R:P407	R:R:S303	1.78	No	No	0	1	3
1753	R:R:G632	R:R:I635	1.76	No	Yes	0	1	4
1754	S:S:G94	S:S:I33	1.76	No	No	0	9	5
1755	S:S:G43	S:S:I61	1.76	No	No	0	2	2
1756	S:S:G613	S:S:I669	1.76	No	Yes	0	8	8
1757	S:S:G632	S:S:I635	1.76	No	No	0	1	4
1758	R:R:G483	R:R:K177	1.74	No	No	0	7	7
1759	S:S:G518	S:S:K517	1.74	No	No	0	3	1
1760	S:S:G553	S:S:K552	1.74	No	No	0	6	8
1761	R:R:C598	R:R:S591	1.72	No	No	0	9	8
1762	R:R:C660	R:R:S663	1.72	No	No	0	7	6
1763	R:R:C661	R:R:S687	1.72	No	No	0	7	6
1764	S:S:C585	S:S:S591	1.72	Yes	No	0	9	8
1765	S:S:C731	S:S:S693	1.72	No	No	0	5	9
1766	R:R:A86	R:R:S84	1.71	No	No	0	3	6
1767	R:R:A300	R:R:S301	1.71	No	No	0	6	5
1768	R:R:G501	R:R:L496	1.71	No	No	0	5	3
1769	R:R:A579	R:R:S574	1.71	No	No	0	7	8
1770	R:R:A581	R:R:S580	1.71	No	No	0	4	4
1771	R:R:G623	R:R:L622	1.71	No	No	0	6	3
1772	R:R:A683	R:R:S664	1.71	No	No	0	5	6
1773	R:R:G720	R:R:L723	1.71	No	No	0	7	7
1774	S:S:A86	S:S:S84	1.71	No	No	0	3	6
1775	S:S:A300	S:S:S301	1.71	No	No	0	6	5
1776	S:S:A321	S:S:S301	1.71	Yes	No	0	5	5
1777	S:S:A321	S:S:S490	1.71	Yes	No	0	5	8
1778	S:S:A579	S:S:S574	1.71	No	No	0	7	8
1779	S:S:A804	S:S:S794	1.71	No	No	0	9	9
1780	R:R:G346	R:R:N345	1.7	No	Yes	0	3	8
1781	R:R:G474	R:R:N471	1.7	No	Yes	0	5	6
1782	S:S:A45	S:S:V58	1.7	No	No	0	1	1
1783	S:S:A107	S:S:V149	1.7	No	No	0	7	4
1784	S:S:A107	S:S:V153	1.7	No	No	0	7	6
1785	S:S:G346	S:S:N345	1.7	No	Yes	0	3	8
1786	S:S:A840	S:S:V817	1.7	No	No	0	9	9
1787	R:R:C236	R:R:T560	1.69	No	No	30	9	4
1788	R:R:I503	R:R:P308	1.69	Yes	No	0	4	2
1789	R:R:C561	R:R:T560	1.69	No	No	30	9	4
1790	S:S:C236	S:S:T560	1.69	No	No	4	9	4
1791	S:S:C561	S:S:T560	1.69	Yes	No	4	9	4
1792	R:R:D570	R:R:G571	1.68	No	No	0	5	7
1793	R:R:A746	R:R:T745	1.68	No	No	0	6	4
1794	S:S:A746	S:S:T745	1.68	No	No	0	6	4
1795	R:R:K863	R:R:P864	1.67	No	No	0	7	8
1796	S:S:K47	S:S:P55	1.67	No	No	0	2	6
1797	R:R:G43	R:R:Q245	1.64	No	No	0	2	4
1798	R:R:E399	R:R:G397	1.64	Yes	No	0	8	5
1799	R:R:E564	R:R:G553	1.64	No	No	0	6	6
1800	R:R:E556	R:R:G557	1.64	No	No	0	6	6
1801	R:R:C851	R:R:I813	1.64	No	No	0	8	8
1802	S:S:L438	S:S:P439	1.64	No	No	0	3	2
1803	S:S:C781	S:S:I777	1.64	No	No	0	7	8
1804	R:R:S244	R:R:S247	1.63	No	No	0	4	2
1805	R:R:S497	R:R:S502	1.63	Yes	No	0	3	4
1806	R:R:A45	R:R:I61	1.62	No	No	0	1	2
1807	R:R:A116	R:R:I135	1.62	No	Yes	0	6	4
1808	R:R:S403	R:R:V404	1.62	No	No	0	2	4
1809	R:R:D410	R:R:P407	1.61	No	No	0	6	1
1810	R:R:S53	S:S:T445	1.6	No	Yes	0	3	1
1811	S:S:S448	S:S:T445	1.6	No	Yes	0	3	1
1812	S:S:V737	S:S:V740	1.6	No	No	0	3	3
1813	R:R:T828	R:R:V833	1.59	No	No	0	8	6
1814	S:S:T617	S:S:V621	1.59	No	No	0	5	4
1815	S:S:C731	S:S:L730	1.59	No	No	0	5	3
1816	S:S:E610	S:S:P611	1.57	No	No	0	7	4
1817	S:S:A645	S:S:N800	1.56	No	Yes	0	9	7
1818	R:R:I401	R:R:S402	1.55	No	No	0	7	4
1819	S:S:I139	S:S:S137	1.55	Yes	No	0	5	4
1820	S:S:I292	S:S:S531	1.55	Yes	No	0	7	4
1821	S:S:I624	S:S:V621	1.54	No	No	0	5	4
1822	S:S:I741	S:S:V740	1.54	No	No	0	4	3
1823	R:R:K106	R:R:S57	1.53	Yes	No	0	4	1
1824	R:R:I741	R:R:T745	1.52	No	No	0	4	4
1825	S:S:C131	S:S:E133	1.52	No	No	0	3	5
1826	S:S:C482	S:S:E481	1.52	No	No	0	7	4
1827	R:R:F612	R:R:G613	1.51	No	No	0	8	8
1828	S:S:F479	S:S:G483	1.51	Yes	No	0	8	7
1829	S:S:A515	S:S:E519	1.51	No	No	0	4	4
1830	R:R:L123	R:R:S122	1.5	Yes	No	0	5	3
1831	R:R:G720	R:R:R701	1.5	No	No	0	7	8
1832	R:R:N592	R:R:S597	1.49	No	No	0	7	1
1833	S:S:N400	S:S:S403	1.49	No	No	0	4	2
1834	R:R:D215	R:R:S244	1.47	Yes	No	0	6	4
1835	R:R:L618	R:R:T617	1.47	No	Yes	0	4	5
1836	R:R:I819	R:R:I822	1.47	No	No	0	6	7
1837	R:R:I819	S:S:I839	1.47	No	No	0	6	7
1838	S:S:D50	S:S:S53	1.47	Yes	No	0	3	3
1839	S:S:D121	S:S:S122	1.47	No	No	0	3	3
1840	S:S:I819	S:S:I822	1.47	No	No	0	6	7
1841	R:R:N592	R:R:T596	1.46	No	No	0	7	5
1842	R:R:N594	R:R:T596	1.46	No	No	0	3	5
1843	S:S:N594	S:S:T596	1.46	No	No	0	3	5
1844	S:S:E59	S:S:S57	1.44	No	No	0	1	1
1845	S:S:P393	S:S:R392	1.44	No	No	0	1	1
1846	R:R:I786	R:R:L782	1.43	No	No	0	4	4
1847	R:R:K349	R:R:L360	1.41	No	Yes	0	3	4
1848	R:R:L770	R:R:M771	1.41	No	No	0	3	3
1849	S:S:G720	S:S:W719	1.41	No	No	0	7	6
1850	R:R:A826	S:S:F832	1.39	No	Yes	0	5	5
1851	R:R:L723	R:R:L726	1.38	No	No	0	7	4
1852	R:R:L726	R:R:L730	1.38	No	No	0	4	3
1853	S:S:L703	S:S:L704	1.38	No	No	0	7	8
1854	R:R:E602	R:R:I603	1.37	No	No	0	3	4
1855	R:R:E602	R:R:I760	1.37	No	No	0	3	5
1856	R:R:K462	S:S:Q49	1.36	Yes	No	0	4	1
1857	S:S:E519	S:S:K516	1.35	No	No	0	4	2
1858	R:R:D587	R:R:D588	1.33	No	No	0	3	6
1859	R:R:N261	R:R:Q260	1.32	No	No	0	4	5
1860	R:R:E799	R:R:N800	1.31	No	No	0	8	7
1861	S:S:E593	S:S:N594	1.31	No	No	0	2	3
1862	S:S:E649	S:S:N647	1.31	No	No	0	7	9
1863	S:S:F729	S:S:V728	1.31	No	No	0	3	7
1864	R:R:D575	R:R:E576	1.3	No	No	0	8	3
1865	S:S:D248	S:S:E250	1.3	No	No	0	3	2
1866	S:S:D500	S:S:E499	1.3	No	No	0	4	4
1867	S:S:F792	S:S:T808	1.3	No	No	0	8	9
1868	R:R:E229	R:R:E232	1.27	Yes	No	0	5	4
1869	R:R:S534	R:R:W530	1.24	No	Yes	0	4	8
1870	S:S:F637	S:S:K636	1.24	No	No	0	4	4
1871	R:R:E353	R:R:H359	1.23	No	No	0	7	4
1872	R:R:F619	R:R:L842	1.22	No	No	0	3	9
1873	S:S:F619	S:S:L618	1.22	No	No	0	3	4
1874	S:S:F619	S:S:L842	1.22	No	No	0	3	9
1875	S:S:F625	S:S:L626	1.22	No	No	0	3	4
1876	S:S:F725	S:S:L726	1.22	No	No	0	5	4
1877	R:R:F725	R:R:N722	1.21	No	No	0	5	3
1878	S:S:T609	S:S:W608	1.21	No	Yes	0	4	5
1879	S:S:D545	S:S:F563	1.19	No	Yes	18	5	7
1880	S:S:D578	S:S:F563	1.19	No	Yes	18	7	7
1881	R:R:L743	R:R:Y744	1.17	No	No	0	7	3
1882	R:R:N90	R:R:Y435	1.16	No	Yes	0	8	3
1883	R:R:L723	R:R:W719	1.14	No	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y20	7.55	4	8	2
2	R:R:F38	7.44	4	2	7
3	R:R:P39	5.5725	4	2	6
4	R:R:I40	6.91	4	2	5
5	R:R:H41	7.48333	6	2	7
6	R:R:F42	11.51	4	26	3
7	R:R:L51	6.4025	4	0	6
8	R:R:Y63	7.95429	7	2	5
9	R:R:N64	8.1275	4	0	4
10	R:R:F65	8.83	4	2	2
11	R:R:R66	9.302	5	2	5
12	R:R:F68	8.796	5	2	7
13	R:R:R69	8.974	5	2	8
14	R:R:W70	7.21222	9	2	5
15	R:R:Q72	7.6575	4	2	7
16	R:R:M74	5.168	5	2	8
17	R:R:Y95	8.838	5	2	8
18	R:R:R96	5.48333	6	8	4
19	R:R:I97	6.605	4	2	8
20	R:R:F98	7.70667	6	8	4
21	R:R:D99	6.81	4	2	9
22	R:R:C101	5.6575	4	2	8
23	R:R:K106	2.7575	4	2	4
24	R:R:E109	4.3875	4	8	5
25	R:R:F114	5.08833	6	8	5
26	R:R:Q117	7.81	4	0	6
27	R:R:L123	4.5225	4	0	5
28	R:R:I135	5.4775	4	0	4
29	R:R:T145	6.37333	6	2	5
30	R:R:N155	5.5275	4	5	5
31	R:R:I162	4.1975	4	0	6
32	R:R:P163	4.476	5	0	8
33	R:R:Q164	5.624	5	0	8
34	R:R:S166	4.3625	4	5	9
35	R:R:Y167	7.686	5	2	8
36	R:R:L173	6.542	5	27	5
37	R:R:L174	7.8	4	5	7
38	R:R:Q179	7.0375	4	5	5
39	R:R:F180	6.3775	4	5	5
40	R:R:F183	8.58	5	5	8
41	R:R:R185	5.706	5	5	9
42	R:R:I187	4.85	4	28	6
43	R:R:F204	8.322	5	6	7
44	R:R:W206	8.815	4	6	9
45	R:R:W208	10.5433	6	9	9
46	R:R:V209	3.834	5	6	8
47	R:R:T211	6.1925	4	0	5
48	R:R:D215	6.87	4	0	6
49	R:R:Y218	5.40833	6	0	7
50	R:R:K225	8.9025	4	0	3
51	R:R:E229	7.74	4	0	5
52	R:R:R233	6.56	5	0	4
53	R:R:I235	4.3975	4	6	7
54	R:R:D238	8.5325	4	9	8
55	R:R:F239	4.86667	6	9	6
56	R:R:I243	4.075	4	31	5
57	R:R:V255	4.8075	4	31	5
58	R:R:V266	4.985	4	6	7
59	R:R:V268	5.6725	4	0	6
60	R:R:F270	5.424	5	0	7
61	R:R:P274	4.1025	4	26	3
62	R:R:E277	4.665	4	0	2
63	R:R:E282	5.57	4	19	6
64	R:R:R286	6.356	5	19	4
65	R:R:W299	8.198	5	12	7
66	R:R:I305	4.5225	4	12	4
67	R:R:Y310	6.06	4	13	3
68	R:R:F311	9.98	4	0	3
69	R:R:V313	4.9425	4	13	3
70	R:R:F320	5.564	5	29	6
71	R:R:I327	5.934	5	2	6
72	R:R:F330	7.758	5	2	8
73	R:R:R331	8.5375	4	2	4
74	R:R:L334	8.9825	4	2	6
75	R:R:N345	3.87286	7	2	8
76	R:R:F347	6.2625	4	2	5
77	R:R:F351	6.88667	6	2	6
78	R:R:T355	4.7375	4	20	4
79	R:R:F356	9.155	4	20	8
80	R:R:L360	5.145	4	0	4
81	R:R:E399	6.01	4	20	8
82	R:R:Y408	8.626	5	2	3
83	R:R:Y411	8.6975	4	2	5
84	R:R:L414	7.025	4	2	6
85	R:R:I416	8.37	4	2	4
86	R:R:S417	5.3725	4	2	6
87	R:R:Y418	6.61333	6	2	7
88	R:R:Y421	9.974	5	2	8
89	R:R:Q432	4.655	4	0	7
90	R:R:Y435	5.335	4	0	3
91	R:R:F444	6.0575	4	14	3
92	R:R:W458	7.83667	6	14	4
93	R:R:Q459	7.8525	4	14	7
94	R:R:K462	6.7825	4	0	4
95	R:R:H463	9.175	4	0	5
96	R:R:L464	3.395	4	0	7
97	R:R:R465	6.235	4	0	5
98	R:R:N471	4.032	5	2	6
99	R:R:D484	5.176	5	5	8
100	R:R:Y489	3.97	4	29	8
101	R:R:I491	4.915	4	0	8
102	R:R:W494	6.77714	7	12	7
103	R:R:S497	3.822	5	0	3
104	R:R:I503	4.07	4	12	4
105	R:R:Y511	8.1575	4	0	5
106	R:R:N512	5.1525	4	32	4
107	R:R:I523	5.2875	4	6	6
108	R:R:W530	8.03	7	6	8
109	R:R:F563	7.6275	4	15	7
110	R:R:W590	5.365	4	0	6
111	R:R:W608	4.875	4	36	5
112	R:R:T617	2.7975	4	36	5
113	R:R:V630	4.6525	4	7	7
114	R:R:F634	5.265	4	7	9
115	R:R:I635	4.3175	4	7	4
116	R:R:R648	4.5875	4	0	8
117	R:R:L650	4.89	4	22	8
118	R:R:Y652	4.532	5	7	7
119	R:R:L654	4.9725	4	0	8
120	R:R:F668	8.4725	4	0	9
121	R:R:I669	4.6525	4	36	8
122	R:R:R678	6.015	4	0	5
123	R:R:F684	9.37	6	0	8
124	R:R:C691	4.065	4	37	8
125	R:R:I695	4.0975	4	0	7
126	R:R:F706	4.985	4	0	9
127	R:R:Q724	9.625	4	22	8
128	R:R:V728	5.195	4	0	7
129	R:R:Q735	8.256	5	39	9
130	R:R:W742	6.832	5	0	9
131	R:R:Y751	6.665	4	40	3
132	R:R:N753	7.73	4	40	7
133	R:R:F762	6.86	4	0	7
134	R:R:I763	5.8525	4	35	7
135	R:R:Y779	8.2375	4	39	9
136	R:R:C787	4.0475	4	0	8
137	R:R:F790	5.7325	4	0	7
138	R:R:L797	4.475	4	0	8
139	R:R:F801	4.275	4	0	9
140	R:R:F814	7.8	5	38	9
141	R:R:F821	5.12833	6	0	9
142	R:R:V838	4.4975	4	0	7
143	R:R:F853	6.89167	6	7	9
144	S:S:F38	6.722	5	1	7
145	S:S:H41	6.48833	6	1	7
146	S:S:F42	11.315	4	43	3
147	S:S:D50	5.16	4	0	3
148	S:S:K52	6.66	4	14	3
149	S:S:C60	5.325	4	1	7
150	S:S:Y63	7.50143	7	1	5
151	S:S:F65	7.682	5	1	2
152	S:S:R66	8.85	4	1	5
153	S:S:F68	7.855	6	1	7
154	S:S:R69	7.3425	4	1	8
155	S:S:W70	7.54625	8	1	5
156	S:S:Q72	8.9025	4	1	7
157	S:S:M74	5.39	4	1	8
158	S:S:F76	7.176	5	1	7
159	S:S:L87	5.215	4	1	6
160	S:S:Y95	8.35	5	1	8
161	S:S:R96	6.835	4	16	4
162	S:S:I97	5.51	5	1	8
163	S:S:F98	7.875	6	16	4
164	S:S:D99	7.4725	4	1	9
165	S:S:C101	6.0625	4	1	8
166	S:S:F114	5.4925	4	16	5
167	S:S:I139	3.6975	4	42	5
168	S:S:T145	5.96333	6	1	5
169	S:S:T151	4.7675	4	3	5
170	S:S:N155	5.42	4	3	5
171	S:S:P163	3.728	5	0	8
172	S:S:Q164	6.73	5	0	8
173	S:S:V165	3.215	4	44	6
174	S:S:Y167	7.868	5	1	8
175	S:S:L173	6.91	4	0	5
176	S:S:L174	7.194	5	3	7
177	S:S:F180	6.9775	4	3	5
178	S:S:F183	7.21833	6	3	8
179	S:S:R185	6.184	5	3	9
180	S:S:I187	5.2775	4	1	6
181	S:S:P188	3.9875	4	1	8
182	S:S:Q193	7.205	6	1	9
183	S:S:D199	7.574	5	1	7
184	S:S:F204	7.588	5	1	7
185	S:S:W206	8.446	5	1	9
186	S:S:W208	6.9625	8	4	9
187	S:S:V209	3.905	4	1	8
188	S:S:D217	3.8325	4	3	6
189	S:S:Y218	6.315	6	1	7
190	S:S:K225	9.24	4	0	3
191	S:S:R227	7.4225	4	0	4
192	S:S:E229	9.115	4	1	5
193	S:S:R233	8.788	5	1	4
194	S:S:D238	7.26	4	4	8
195	S:S:F239	5.586	5	4	6
196	S:S:V266	7.355	4	1	7
197	S:S:F270	6.8725	4	1	7
198	S:S:P274	4.862	5	43	3
199	S:S:D275	3.9175	4	0	5
200	S:S:I283	4.4775	4	0	4
201	S:S:R286	5.0325	4	0	4
202	S:S:I292	4.1875	4	1	7
203	S:S:W293	6.88	4	4	8
204	S:S:W299	8.27	5	17	7
205	S:S:I305	4.94833	6	17	4
206	S:S:Y310	7.428	5	45	3
207	S:S:F311	9.695	4	0	3
208	S:S:F320	6.232	5	1	6
209	S:S:A321	3.395	4	0	5
210	S:S:L322	5.805	4	1	4
211	S:S:I327	5.348	5	1	6
212	S:S:F330	6.814	5	1	8
213	S:S:F333	9.7275	4	1	7
214	S:S:N345	4.502	5	1	8
215	S:S:F351	8.76667	6	1	6
216	S:S:W352	13.51	4	1	8
217	S:S:T355	5.71	4	1	4
218	S:S:F356	11.6275	4	1	8
219	S:S:Y408	8.495	8	1	3
220	S:S:Y411	10.9425	4	0	5
221	S:S:I416	7.45	4	1	4
222	S:S:Y418	6.04	5	1	7
223	S:S:Y421	6.8375	4	1	8
224	S:S:Y425	5.74	5	1	8
225	S:S:I427	4.4825	4	0	5
226	S:S:F444	4.12333	6	10	3
227	S:S:T445	3.3875	4	0	1
228	S:S:E456	7.6175	4	10	5
229	S:S:W458	11.514	5	10	4
230	S:S:Q459	8.382	5	10	7
231	S:S:K462	8.2325	4	10	4
232	S:S:H463	7.33	4	0	5
233	S:S:L464	3.715	4	0	7
234	S:S:N471	6.6825	4	1	6
235	S:S:M473	5.14	5	1	4
236	S:S:F479	5.935	4	0	8
237	S:S:D484	4.6675	4	3	8
238	S:S:Y489	4.564	5	1	8
239	S:S:W494	7.10167	6	17	7
240	S:S:S497	3.56	5	0	3
241	S:S:Y511	6.72	6	1	5
242	S:S:N512	4.57	4	1	4
243	S:S:V513	6.57	4	1	3
244	S:S:L521	4.79	5	1	5
245	S:S:E525	5.66	5	1	4
246	S:S:I528	6.5425	4	1	7
247	S:S:W530	8.9975	8	1	8
248	S:S:T550	5.5275	4	18	6
249	S:S:C561	5.65	4	4	9
250	S:S:F563	7.366	5	18	7
251	S:S:C585	4.0825	4	0	9
252	S:S:D588	7.18	4	21	6
253	S:S:H595	6.8175	4	0	5
254	S:S:W608	4.3525	4	0	5
255	S:S:T640	7.0275	4	48	9
256	S:S:I642	4.875	4	48	7
257	S:S:T646	5.805	4	49	9
258	S:S:L654	6.125	4	0	8
259	S:S:F662	7.4875	4	0	8
260	S:S:F668	8.0225	4	0	9
261	S:S:I669	3.04	4	0	8
262	S:S:R678	7.19	4	0	5
263	S:S:R680	6.778	5	0	8
264	S:S:F684	11.326	5	11	8
265	S:S:F688	6.686	5	0	8
266	S:S:V689	7.025	4	0	7
267	S:S:C691	5.2925	4	0	8
268	S:S:Q724	7.0775	4	0	8
269	S:S:Q735	7.214	5	0	9
270	S:S:W742	5.382	5	0	9
271	S:S:I761	6.924	5	21	7
272	S:S:F762	5.0825	4	0	7
273	S:S:H766	3.74	4	0	6
274	S:S:F790	3.535	4	0	7
275	S:S:N800	5.75	5	49	7
276	S:S:K805	6.2375	4	23	9
277	S:S:F806	7.02	4	23	5
278	S:S:F809	5.7825	4	23	9
279	S:S:F814	7.6175	4	0	9
280	S:S:W818	10.226	5	11	9
281	S:S:F821	7.8675	4	11	9
282	S:S:Y825	8.07	4	11	9
283	S:S:F832	7.3875	4	0	5
284	S:S:F853	6.22	4	47	9
285	W:W:W1	5.02	8	2	0
286	W:W:?2	12.5967	6	2	0
287	W:W:?4	11.631	10	38	0
288	X:X:W1	6.57	7	1	0
289	X:X:?2	8.61167	6	1	0
290	X:X:?4	11.7387	8	11	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I554	S:S:I554	96.985	2.94	No	No	0	3	3
2	R:R:K552	S:S:I554	97.3276	8.72	No	No	0	8	3
3	R:R:D578	R:R:K552	97.3182	6.91	No	No	15	7	8
4	R:R:D545	R:R:D578	97.9256	14.64	No	No	0	5	7
5	R:R:D545	R:R:N541	98.0961	2.69	No	No	0	5	5
6	R:R:N207	R:R:N541	98.3516	12.26	No	No	0	6	5
7	R:R:C561	R:R:N207	98.4366	7.87	No	No	0	9	6
8	R:R:C236	R:R:C561	98.5024	7.28	No	No	30	9	9
9	R:R:C236	R:R:P559	98.6916	3.77	No	No	0	9	6
10	R:R:P559	R:R:W208	99.0961	8.11	No	Yes	0	6	9
11	R:R:D238	R:R:W208	99.8312	20.1	Yes	Yes	9	8	9
12	R:R:D238	R:R:F239	100	3.58	Yes	Yes	9	8	6
13	R:R:F239	R:R:G210	61.9948	9.03	Yes	No	0	6	8
14	R:R:G210	R:R:V209	62.03	3.68	No	Yes	0	8	8
15	R:R:I235	R:R:V209	61.7632	3.07	Yes	Yes	6	7	8
16	R:R:I235	R:R:R233	61.9212	3.76	Yes	Yes	0	7	4
17	R:R:E229	R:R:R233	64.2259	3.49	Yes	Yes	0	5	4
18	R:R:E229	R:R:K225	64.3196	13.5	Yes	Yes	0	5	3
19	R:R:E191	R:R:K225	64.4324	14.85	No	Yes	0	3	3
20	R:R:F239	R:R:I212	40.2663	3.77	Yes	No	0	6	6
21	R:R:I212	R:R:I243	40.2846	4.42	No	Yes	0	6	5
22	R:R:I243	R:R:S271	40.6245	3.1	Yes	No	0	5	4
23	R:R:A214	R:R:S271	40.6517	3.42	No	No	0	5	4
24	R:R:E191	R:R:R172	57.3993	8.14	No	No	0	3	4
25	R:R:L173	R:R:R172	36.2092	6.07	Yes	No	0	5	4
26	R:R:L173	S:S:R220	50.7435	8.5	Yes	No	0	5	6
27	S:S:D217	S:S:R220	71.9099	3.57	Yes	No	0	6	6
28	S:S:D217	S:S:T151	47.3819	4.34	Yes	Yes	3	6	5
29	S:S:L174	S:S:T151	46.8487	5.9	Yes	Yes	3	7	5
30	S:S:F183	S:S:L174	10.163	13.4	Yes	Yes	3	8	7
31	S:S:F183	S:S:Q164	10.3573	10.54	Yes	Yes	0	8	8
32	S:S:L157	S:S:Q164	10.8475	7.99	No	Yes	0	7	8
33	R:R:A214	R:R:D216	34.4941	3.09	No	No	0	5	6
34	R:R:D216	R:R:Y218	34.5252	3.45	No	Yes	0	6	7
35	R:R:S147	R:R:Y218	51.3	5.09	No	Yes	0	8	7
36	R:R:S147	R:R:S171	51.3176	4.89	No	No	0	8	7
37	R:R:L173	R:R:S171	51.2967	4.5	Yes	No	27	5	7
38	R:R:R172	S:S:D215	21.2632	10.72	No	No	0	4	6
39	S:S:D215	S:S:R220	21.2565	7.15	No	No	0	6	6
40	R:R:D217	R:R:L173	37.1818	5.43	No	Yes	0	6	5
41	R:R:D217	R:R:R220	38.3923	3.57	No	No	0	6	6
42	R:R:D215	R:R:R220	19.2535	7.15	Yes	No	0	6	6
43	R:R:D215	S:S:R172	18.9875	10.72	Yes	No	0	6	4
44	R:R:R220	S:S:L173	19.2476	10.93	No	Yes	0	6	5
45	S:S:L173	S:S:R172	43.6035	6.07	Yes	No	0	5	4
46	S:S:D217	S:S:L173	25.3548	4.07	Yes	Yes	0	6	5
47	R:R:A298	R:R:Y218	13.4198	4	No	Yes	0	6	7
48	R:R:I554	S:S:K552	96.4699	18.9	No	No	0	3	8
49	S:S:F563	S:S:K552	96.2978	22.33	Yes	No	0	7	8
50	S:S:C546	S:S:F563	95.7807	4.19	No	Yes	18	9	7
51	S:S:C546	S:S:T550	95.5895	6.76	No	Yes	18	9	6
52	S:S:E567	S:S:T550	95.4352	5.64	No	Yes	0	4	6
53	S:S:E567	S:S:H595	95.3487	7.39	No	Yes	0	4	5
54	S:S:H595	S:S:S591	91.1493	5.58	Yes	No	0	5	8
55	S:S:G571	S:S:S591	90.2626	3.71	No	No	0	7	8
56	S:S:G571	S:S:W590	90.1737	9.85	No	No	0	7	6
57	S:S:E759	S:S:W590	90.0847	13.08	No	No	0	4	6
58	S:S:E757	S:S:E759	89.9067	6.34	No	No	0	4	4
59	S:S:E757	S:S:I760	89.8177	5.47	No	No	0	4	5
60	S:S:F762	S:S:I760	89.6394	6.28	Yes	No	0	7	5
61	S:S:E604	S:S:F762	89.3718	4.66	No	Yes	0	6	7
62	S:S:E604	S:S:K831	89.2825	9.45	No	No	0	6	9
63	S:S:F832	S:S:K831	89.1931	12.41	Yes	No	0	5	9
64	S:S:F612	S:S:F832	52.2933	11.79	No	Yes	0	8	5
65	R:R:P823	S:S:F612	52.0835	5.78	No	No	0	9	8
66	R:R:I822	R:R:P823	51.7594	3.39	No	No	0	7	9
67	R:R:I822	W:W:?4	51.5584	4.17	No	Yes	0	7	0
68	R:R:F684	W:W:?4	19.9552	18.66	Yes	Yes	0	8	0
69	R:R:F684	R:R:F688	17.6293	7.5	Yes	No	0	8	8
70	R:R:F688	R:R:I692	34.8719	8.79	No	No	0	8	7
71	R:R:C787	R:R:I692	34.6425	3.27	Yes	No	0	8	7
72	R:R:C787	R:R:I695	31.4273	3.27	Yes	Yes	0	8	7
73	R:R:I695	R:R:L654	18.8891	4.28	Yes	Yes	0	7	8
74	R:R:F814	W:W:?4	17.9943	3.56	Yes	Yes	38	9	0
75	R:R:F688	R:R:F814	17.4754	13.93	No	Yes	0	8	9
76	R:R:S827	S:S:F832	43.7755	3.96	No	Yes	0	8	5
77	R:R:S827	S:S:T828	43.6674	3.2	No	No	0	8	8
78	S:S:T828	S:S:V833	43.5592	6.35	No	No	0	8	6
79	S:S:V833	S:S:Y825	43.451	5.05	No	Yes	0	6	9
80	S:S:Y825	X:X:?4	36.8555	10.27	Yes	Yes	11	9	0
81	S:S:F684	X:X:?4	23.2698	19.55	Yes	Yes	11	8	0
82	S:S:F684	S:S:F688	23.1331	10.72	Yes	Yes	0	8	8
83	S:S:L174	S:S:S171	37.2351	4.5	Yes	No	0	7	7
84	S:S:S147	S:S:S171	37.1718	6.52	No	No	0	8	7
85	S:S:S147	X:X:W1	37.1095	6.18	No	Yes	0	8	0
86	S:S:T145	X:X:W1	33.3269	4.85	Yes	Yes	1	5	0
87	S:S:T145	S:S:W70	28.8947	7.28	Yes	Yes	1	5	5
88	S:S:R66	S:S:W70	12.1894	8	Yes	Yes	1	5	5
89	S:S:R66	S:S:R69	13.1862	3.2	Yes	Yes	1	5	8
90	S:S:R69	S:S:Y408	24.52	3.09	Yes	Yes	1	8	3
91	S:S:W70	X:X:?2	12.4892	9.17	Yes	Yes	1	5	0
92	S:S:R69	X:X:?2	13.315	5.59	Yes	Yes	1	8	0
93	S:S:E191	S:S:R172	62.2771	9.3	No	No	0	3	4
94	S:S:E191	S:S:K225	62.6159	13.5	No	Yes	0	3	3
95	S:S:E229	S:S:K225	62.1912	10.8	Yes	Yes	0	5	3
96	S:S:E229	S:S:T195	30.7465	11.29	Yes	No	0	5	4
97	S:S:D199	S:S:T195	30.5878	4.34	Yes	No	0	7	4
98	S:S:E229	S:S:R233	31.1227	9.3	Yes	Yes	1	5	4
99	S:S:D199	S:S:R233	30.6466	10.72	Yes	Yes	1	7	4
100	S:S:D199	S:S:L521	51.8536	4.07	Yes	Yes	1	7	5
101	S:S:L521	S:S:Y203	27.1577	3.52	Yes	No	1	5	5
102	S:S:F204	S:S:Y203	26.7382	7.22	Yes	No	1	7	5
103	S:S:F204	S:S:W206	13.9353	11.02	Yes	Yes	1	7	9
104	S:S:I523	S:S:L521	27.1577	8.56	No	Yes	1	6	5
105	S:S:F204	S:S:I523	26.7382	5.02	Yes	No	1	7	6
106	S:S:E525	S:S:F204	18.6973	4.66	Yes	Yes	1	4	7
107	S:S:F204	S:S:W530	20.0079	10.02	Yes	Yes	1	7	8
108	S:S:E525	S:S:I528	12.8447	6.83	Yes	Yes	1	4	7
109	S:S:I528	S:S:N493	19.5247	4.25	Yes	No	0	7	9
110	S:S:I528	S:S:W530	13.187	5.87	Yes	Yes	1	7	8
111	S:S:H495	S:S:N493	16.271	10.2	No	No	0	7	9
112	S:S:H495	S:S:K506	13.0171	7.86	No	No	0	7	5
113	S:S:K506	S:S:V504	11.3901	3.04	No	No	0	5	3
114	S:S:F688	S:S:L848	18.6117	3.65	Yes	No	0	8	7
115	S:S:C691	S:S:L848	10.3186	6.35	Yes	No	0	8	7
116	S:S:C694	S:S:L654	11.9414	7.94	No	Yes	0	6	8
117	S:S:C694	S:S:L650	17.4361	4.76	No	No	0	6	8
118	R:R:A298	W:W:W1	13.3663	5.19	No	Yes	0	6	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:P39	S:S:W70	5.4	1	No	Yes	6	5	2	2
S:S:P39	S:S:T145	8.74	1	No	Yes	6	5	2	1
S:S:T145	S:S:W70	7.28	1	Yes	Yes	5	5	1	2
S:S:W70	S:S:Y167	5.79	1	Yes	Yes	5	8	2	2
S:S:G146	S:S:T145	3.64	1	No	Yes	5	5	1	1
S:S:T145	S:S:Y167	6.24	1	Yes	Yes	5	8	1	2
S:S:A168	S:S:T145	5.03	1	No	Yes	5	5	1	1
S:S:T145	X:X:W1	4.85	1	Yes	Yes	5	0	1	0
S:S:G146	S:S:V149	3.68	1	No	No	5	4	1	2
S:S:G146	X:X:W1	4.22	1	No	Yes	5	0	1	0
S:S:S147	S:S:S171	6.52	0	No	No	8	7	1	2
S:S:S147	X:X:W1	6.18	0	No	Yes	8	0	1	0
S:S:A168	X:X:W1	3.89	1	No	Yes	5	0	1	0
S:S:I187	S:S:S170	4.64	1	Yes	No	6	7	2	1
S:S:D190	S:S:S170	10.31	0	No	No	8	7	2	1
S:S:S170	X:X:W1	4.94	0	No	Yes	7	0	1	0
S:S:D190	S:S:Y218	5.75	0	No	Yes	8	7	2	1
S:S:D216	S:S:Y218	3.45	0	No	Yes	6	7	2	1
S:S:S296	S:S:Y218	6.36	1	No	Yes	8	7	2	1
S:S:A298	S:S:Y218	4	1	No	Yes	6	7	1	1
S:S:Y218	X:X:W1	15.43	1	Yes	Yes	7	0	1	0
S:S:A298	X:X:W1	6.48	1	No	Yes	6	0	1	0
S:S:G219	S:S:Y218	2.9	0	No	Yes	7	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:F684	S:S:S664	5.28	11	Yes	No	8	6	1	2
S:S:F668	S:S:R680	13.9	0	Yes	Yes	9	8	2	2
S:S:E837	S:S:F668	10.49	11	No	Yes	9	9	1	2
S:S:F668	S:S:I841	3.77	0	Yes	No	9	9	2	2
S:S:Q681	S:S:R680	7.01	0	No	Yes	9	8	1	2
S:S:L773	S:S:Q681	5.32	0	No	No	8	9	2	1
S:S:Q681	X:X:?4	7.77	0	No	Yes	9	0	1	0
S:S:F684	S:S:F688	10.72	11	Yes	Yes	8	8	1	2
S:S:F684	S:S:W818	6.01	11	Yes	Yes	8	9	1	1
S:S:F684	S:S:I841	15.07	11	Yes	No	8	9	1	2
S:S:F684	X:X:?4	19.55	11	Yes	Yes	8	0	1	0
S:S:F688	S:S:F814	7.5	0	Yes	Yes	8	9	2	2
S:S:T780	S:S:V689	3.17	0	No	Yes	7	7	1	2
S:S:E767	S:S:L770	7.95	0	No	No	7	3	2	1
S:S:L770	X:X:?4	6.06	0	No	Yes	3	0	1	0
S:S:I777	X:X:?4	18.75	0	No	Yes	8	0	1	0
S:S:T780	X:X:?4	6.45	0	No	Yes	7	0	1	0
S:S:F814	S:S:W818	7.02	0	Yes	Yes	9	9	2	1
S:S:F821	S:S:W818	12.03	11	Yes	Yes	9	9	2	1
S:S:A840	S:S:W818	7.78	11	No	Yes	9	9	2	1
S:S:W818	X:X:?4	18.29	11	Yes	Yes	9	0	1	0
S:S:F821	S:S:Y825	11.35	11	Yes	Yes	9	9	2	1
S:S:A840	S:S:F821	4.16	11	No	Yes	9	9	2	2
S:S:V833	S:S:Y825	5.05	0	No	Yes	6	9	2	1
S:S:E837	S:S:Y825	5.61	11	No	Yes	9	9	1	1
S:S:Y825	X:X:?4	10.27	11	Yes	Yes	9	0	1	0
S:S:E837	X:X:?4	6.77	11	No	Yes	9	0	1	0
S:S:C781	S:S:I777	1.64	0	No	No	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N64	R:R:P39	3.26	0	Yes	Yes	4	6	2	2
R:R:P39	R:R:W70	5.4	2	Yes	Yes	6	5	2	1
R:R:P39	R:R:T145	8.74	2	Yes	Yes	6	5	2	1
R:R:N64	R:R:R66	3.62	0	Yes	Yes	4	5	2	1
R:R:G67	R:R:N64	5.09	0	No	Yes	4	4	2	2
R:R:R66	R:R:R69	5.33	2	Yes	Yes	5	8	1	2
R:R:R66	R:R:W70	7	2	Yes	Yes	5	5	1	1
R:R:R66	W:W:W1	4	2	Yes	Yes	5	0	1	0
R:R:R66	W:W:?2	26.56	2	Yes	Yes	5	0	1	2
R:R:G67	R:R:W70	5.63	0	No	Yes	4	5	2	1
R:R:R69	R:R:S417	6.59	2	Yes	Yes	8	6	2	2
R:R:R69	W:W:?2	16.77	2	Yes	Yes	8	0	2	2
R:R:T145	R:R:W70	7.28	2	Yes	Yes	5	5	1	1
R:R:W70	R:R:Y167	3.86	2	Yes	Yes	5	8	1	2
R:R:I416	R:R:W70	12.92	2	Yes	Yes	4	5	1	1
R:R:S417	R:R:W70	3.71	2	Yes	Yes	6	5	2	1
R:R:W70	W:W:W1	4.69	2	Yes	Yes	5	0	1	0
R:R:W70	W:W:?2	14.42	2	Yes	Yes	5	0	1	2
R:R:G146	R:R:T145	3.64	0	No	Yes	5	5	2	1
R:R:T145	R:R:Y167	7.49	2	Yes	Yes	5	8	1	2
R:R:A168	R:R:T145	5.03	2	No	Yes	5	5	1	1
R:R:T145	W:W:W1	6.06	2	Yes	Yes	5	0	1	0
R:R:I416	R:R:Y167	4.84	2	Yes	Yes	4	8	1	2
R:R:A168	W:W:W1	5.19	2	No	Yes	5	0	1	0
R:R:E297	R:R:Q193	5.1	0	No	No	8	9	1	2
R:R:A298	R:R:Y218	4	0	No	Yes	6	7	1	2
R:R:D275	R:R:S272	7.36	0	No	No	5	5	2	1
R:R:S272	W:W:W1	3.71	0	No	Yes	5	0	1	0
R:R:E297	R:R:L322	10.6	0	No	No	8	4	1	2
R:R:E297	W:W:W1	5.45	0	No	Yes	8	0	1	0
R:R:A298	W:W:W1	5.19	0	No	Yes	6	0	1	0
R:R:I416	W:W:W1	5.87	2	Yes	Yes	4	0	1	0
R:R:I416	W:W:?2	9.85	2	Yes	Yes	4	0	1	2
R:R:S417	W:W:?2	5.18	2	Yes	Yes	6	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C661	R:R:F684	4.19	0	No	Yes	7	8	2	1
R:R:F684	R:R:S664	5.28	0	Yes	No	8	6	1	2
R:R:E837	R:R:F668	9.33	0	No	Yes	9	9	1	2
R:R:F668	R:R:I841	3.77	0	Yes	No	9	9	2	2
R:R:Q681	R:R:W742	6.57	0	No	Yes	9	9	1	2
R:R:L773	R:R:Q681	13.31	0	No	No	8	9	2	1
R:R:Q681	W:W:?4	6.8	0	No	Yes	9	0	1	0
R:R:F684	R:R:F688	7.5	0	Yes	No	8	8	1	2
R:R:F684	R:R:I841	17.58	0	Yes	No	8	9	1	2
R:R:F684	W:W:?4	18.66	0	Yes	Yes	8	0	1	0
R:R:F688	R:R:F814	13.93	0	No	Yes	8	9	2	1
R:R:L776	R:R:Q735	10.65	0	No	Yes	8	9	1	2
R:R:Q735	R:R:T780	5.67	39	Yes	No	9	7	2	1
R:R:I738	R:R:L776	4.28	0	No	No	8	8	2	1
R:R:I777	R:R:L773	4.28	0	No	No	8	8	1	2
R:R:L776	W:W:?4	4.04	0	No	Yes	8	0	1	0
R:R:G778	R:R:I777	3.53	0	No	No	5	8	2	1
R:R:I777	W:W:?4	16.66	0	No	Yes	8	0	1	0
R:R:T780	W:W:?4	6.45	0	No	Yes	7	0	1	0
R:R:F814	R:R:F815	10.72	38	Yes	No	9	7	1	2
R:R:F814	R:R:W818	8.02	38	Yes	No	9	9	1	1
R:R:F814	W:W:?4	3.56	38	Yes	Yes	9	0	1	0
R:R:A840	R:R:W818	7.78	0	No	No	9	9	2	1
R:R:W818	W:W:?4	33.25	38	No	Yes	9	0	1	0
R:R:I822	R:R:P823	3.39	0	No	No	7	9	1	2
R:R:I822	W:W:?4	4.17	0	No	Yes	7	0	1	0
R:R:Y825	W:W:?4	11.12	0	No	Yes	9	0	1	0
R:R:E837	W:W:?4	11.6	0	No	Yes	9	0	1	0
R:R:F684	R:R:G685	3.01	0	Yes	No	8	8	1	2
R:R:A844	R:R:F814	2.77	0	No	Yes	9	9	2	1
R:R:I819	R:R:I822	1.47	0	No	No	6	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8WPU_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	1567
Number of Links	1883
Number of Hubs	290
Number of Links mediated by Hubs	1068
Number of Communities	49
Number of Nodes involved in Communities	404
Number of Links involved in Communities	567

Path Summary
Number Of Nodes in MetaPath	119
Number Of Links MetaPath	118
Number of Shortest Paths	7690736
Length Of Smallest Path	3
Average Path Length	47.6044
Length of Longest Path	88
Minimum Path Strength	1.22
Average Path Strength	7.45209
Maximum Path Strength	25.955
Minimum Path Correlation	0.71
Average Path Correlation	0.999126
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2
Average % Of Corr. Nodes	63.4895
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.8242
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • amino acid binding • identical protein binding • protein binding • cation binding • ion binding • calcium ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • phosphoric ester hydrolase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • phospholipase C activity • hydrolase activity • phosphatidylinositol-4,5-bisphosphate phospholipase C activity • catalytic activity • phospholipase activity • lipase activity • transmembrane transporter binding • cell adhesion molecule binding • protein-containing complex binding • integrin binding • signaling receptor binding • protein homodimerization activity • protein dimerization activity • kinase binding • enzyme binding • protein kinase binding • biological regulation • regulation of biological quality • regulation of presynaptic membrane potential • regulation of membrane potential • regulation of calcium ion transport • regulation of localization • regulation of biological process • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization
Gene Ontology	Biological Process	• biological regulation • regulation of biological quality • regulation of presynaptic membrane potential • regulation of membrane potential • regulation of calcium ion transport • regulation of localization • regulation of biological process • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • developmental process • multicellular organismal process • epithelium development • tube development • branching morphogenesis of an epithelial tube • morphogenesis of an epithelium • tissue development • tissue morphogenesis • anatomical structure morphogenesis • multicellular organism development • tube morphogenesis • morphogenesis of a branching structure • anatomical structure development • epithelial tube morphogenesis • morphogenesis of a branching epithelium • regulation of tube diameter • system process • regulation of tube size • regulation of system process • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • monoatomic ion transmembrane transport • inorganic ion transmembrane transport • inorganic anion transmembrane transport • chloride transport • transmembrane transport • chloride transmembrane transport • monoatomic anion transport • monoatomic anion transmembrane transport • cellular process • inorganic anion transport • regulation of biosynthetic process • regulation of cellular process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • response to stimulus • response to stress • response to ischemia • response to decreased oxygen levels • cellular response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to chemical • response to oxygen levels • response to abiotic stimulus • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • organic acid transport • bile acid secretion • organic anion transport • monocarboxylic acid transport • carboxylic acid transport • secretion • acid secretion • response to peptide • cellular response to peptide • behavior • chemosensory behavior • signaling • intracellular signal transduction • cell communication • JNK cascade • intracellular signaling cassette • MAPK cascade • signal transduction • cellular response to low-density lipoprotein particle stimulus • response to endogenous stimulus • response to lipoprotein particle • response to nitrogen compound • cellular response to lipoprotein particle stimulus • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of calcium ion import • positive regulation of calcium ion transport • positive regulation of calcium ion import • positive regulation of transport • positive regulation of monoatomic ion transport • calcium ion import • ossification • connective tissue development • adipose tissue development • fat pad development • animal organ development • response to fibroblast growth factor • response to growth factor • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • response to oxygen-containing compound • cellular response to glucose stimulus • intracellular glucose homeostasis • cellular response to oxygen-containing compound • response to hexose • cellular response to carbohydrate stimulus • response to monosaccharide • response to carbohydrate • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • response to nutrient levels • response to lipid • response to nutrient • response to vitamin • cellular response to vitamin D • cellular response to nutrient levels • response to vitamin D • cellular response to vitamin • cellular response to lipid • cellular response to nutrient • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • vasodilation • positive chemotaxis • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of positive chemotaxis • response to external stimulus • regulation of chemotaxis • positive regulation of chemotaxis • regulation of positive chemotaxis • positive regulation of response to external stimulus • taxis • regulation of locomotion • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular response to endogenous stimulus • response to hepatocyte growth factor • cellular response to growth factor stimulus • cellular response to hepatocyte growth factor stimulus • protein localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • cellular macromolecule localization • positive regulation of insulin secretion • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of secretion • positive regulation of protein localization • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • amide transport • signal release • positive regulation of peptide secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • detection of stimulus • response to metal ion • detection of chemical stimulus • detection of calcium ion • response to calcium ion • cell periphery • presynapse • cellular anatomical structure • synapse • cell junction • membrane • plasma membrane • presynaptic membrane • plasma membrane region • synaptic membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • glutamatergic synapse
Gene Ontology	Cellular Component	• cell periphery • presynapse • cellular anatomical structure • synapse • cell junction • membrane • plasma membrane • presynaptic membrane • plasma membrane region • synaptic membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • glutamatergic synapse • somatodendritic compartment • cell body • neuronal cell body • apical part of cell • apical plasma membrane • cell surface • axon • neuron projection • axon terminus • plasma membrane bounded cell projection • cell projection • distal axon • neuron projection terminus • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • D1 dopamine receptor binding • dopamine receptor binding • G protein activity • molecular function regulator activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • multicellular organismal process • renal system process • system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • negative regulation of lyase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to nitrogen compound • cellular response to acetylcholine • response to oxygen-containing compound • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • response to nutrient levels • response to nutrient • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • response to hormone • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • protein localization • establishment of protein localization • nitrogen compound transport • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • amide transport • signal release • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • dendrite • dendritic tree • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • cilium • ciliary basal body • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Type 1 solute binding protein-like • TNF receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Type 1 solute binding protein-like • TNF receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CA
PDB Residues	I:I:?1 I:I:?2 W:W:?3 X:X:?3
Environment Details	Open EMBL-EBI Page
Code	CA
Name	CALCIUM ION
Synonyms
Identifier
Formula	Ca
Molecular Weight	40.078
SMILES
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


Code	PO4
PDB Residues	W:W:?2 X:X:?2
Environment Details	Open EMBL-EBI Page
Code	PO4
Name	Phosphate ion
Synonyms	Phosphate Phosphate ion Orthophosphate
Identifier
Formula	O4 P
Molecular Weight	94.971
SMILES
PubChem	1061
Formal Charge	-3
Total Atoms	5
Total Chiral Atoms	0
Total Bonds	4
Total Aromatic Bonds	0


Code	YP4
PDB Residues	W:W:?4 X:X:?4
Environment Details	Open EMBL-EBI Page
Code	YP4
Name	Cinacalcet
Synonyms	Cinacalcet hydrochloride (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine Cinacalcet CNC
Identifier
Formula	C22 H22 F3 N
Molecular Weight	357.412
SMILES
PubChem	156419
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	1
Total Bonds	50
Total Aromatic Bonds	17


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41180
Sequence	>8WPU_nogp_Chain_R Y G P D Q R A Q K K G D I I L G G L F P I H F G V A A K D Q D L K S R P E S V E C I R Y N F R G F R W L Q A M I F A I E E I N S S P A L L P N L T L G Y R I F D T C N T V S K A L E A T L S F V A Q N K I D S L N L D C S E H I P S T I A V V G A T G S G V S T A V A N L L G L F Y I P Q V S Y A S S S R L L S N K N Q F K S F L R T I P N D E H Q A T A M A D I I E Y F R W N W V G T I A A D D D Y G R P G I E K F R E E A E E R D I C I D F S E L I S Q Y S D E E E I Q H V V E V I Q N S T A K V I V V F S S G P D L E P L I K E I V R R N I T G K I W L A S E A W A S S S L I A M P Q Y F H V V G G T I G F A L K A G Q I P G F R E F L K K V H P R K S V H N G F A K E F W E E T F N C H L Q R P L C T G D E N I S S V E T P Y I D Y T H L R I S Y N V Y L A V Y S I A H A L Q D I Y T C L P G R G L F T N G S C A D I K K V E A W Q V L K H L R H L N F T N N M G E Q V T F D E C G D L V G N Y S I I N W H L S P E D G S I V F K E V G Y Y N V Y A K K G E R L F I N E E K I L W S G F S R E V P F S N C S R D C L A G T R K G I I E G E P T C C F E C V E C P D G E Y S D E T D A S A C N K C P D D F W S N E N H T S C I A K E I E F L S W T E P F G I A L T L F A V L G I F L T A F V L G V F I K F R N T P I V K A T N R E L S Y L L L F S L L C C F S S S L F F I G E P Q D W T C R L R Q P A F G I S F V L C I S C I L V K T N R V L L V F E A K W G L N L Q F L L V F L C T F M Q I V I C V I W L Y T A P P S S Y R N Q E L E D E I I F I T C H E G S L M A L G F L I G Y T C L L A A I C F F F A F K S R K L P E N F N E A K F I T F S M L I F F I V W I S F I P A Y A S T Y G K F V S A V E V I A I L A A S F G L L A C I F F N K I Y I I L F K P S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	S
Protein	Receptor
UniProt	P41180
Sequence	>8WPU_nogp_Chain_S Y G P D Q R A Q K K G D I I L G G L F P I H F G V A A K D Q D L K S R P E S V E C I R Y N F R G F R W L Q A M I F A I E E I N S S P A L L P N L T L G Y R I F D T C N T V S K A L E A T L S F V A Q N K I D S L N L C S E H I P S T I A V V G A T G S G V S T A V A N L L G L F Y I P Q V S Y A S S S R L L S N K N Q F K S F L R T I P N D E H Q A T A M A D I I E Y F R W N W V G T I A A D D D Y G R P G I E K F R E E A E E R D I C I D F S E L I S Q Y S D E E E I Q H V V E V I Q N S T A K V I V V F S S G P D L E P L I K E I V R R N I T G K I W L A S E A W A S S S L I A M P Q Y F H V V G G T I G F A L K A G Q I P G F R E F L K K V H P R K S V H N G F A K E F W E E T F N C H L Q F R P L C T G D E N I S S V E T P Y I D Y T H L R I S Y N V Y L A V Y S I A H A L Q D I Y T C L P G R G L F T N G S C A D I K K V E A W Q V L K H L R H L N F T N N M G E Q V T F D E C G D L V G N Y S I I N W H L S P E D G S I V F K E V G Y Y N V Y A K K G E R L F I N E E K I L W S G F S R E V P F S N C S R D C L A G T R K G I I E G E P T C C F E C V E C P D G E Y S D E T D A S A C N K C P D D F W S N E N H T S C I A K E I E F L S W T E P F G I A L T L F A V L G I F L T A F V L G V F I K F R N T P I V K A T N R E L S Y L L L F S L L C C F S S S L F F I G E P Q D W T C R L R Q P A F G I S F V L C I S C I L V K T N R V L L V K W W G L N L Q F L L V F L C T F M Q I V I C V I W L Y T A P P S S Y R N Q E L E D E I I F I T C H E G S L M A L G F L I G Y T C L L A A I C F F F A F K S R K L P E N F N E A K F I T F S M L I F F I V W I S F I P A Y A S T Y G K F V S A V E V I A I L A A S F G L L A C I F F N K I Y I I L F K P S R N T I E E V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9C2F	C	Ion	Calcium Sensing	CaS	Homo sapiens	Ca	Ca; Ca; Tryptophan; '6218; PO4	-	2.8	2024-10-02	10.1126/science.ado1868
	9C1P	C	Ion	Calcium Sensing	CaS	Homo sapiens	Ca	Ca; Tryptophan; '6218; PO4	-	2.8	2024-10-02	10.1126/science.ado1868
	9AXF	C	Ion	Calcium Sensing	CaS	Homo sapiens	Ca	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	chim(NtGi1-Gs-CtGq)/β1/γ2	3.5	2024-04-17	10.1038/s41586-024-07331-1
	9AXF (No Gprot)	C	Ion	Calcium Sensing	CaS	Homo sapiens	Ca	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4		3.5	2024-04-17	10.1038/s41586-024-07331-1
	9ASB	C	Ion	Calcium Sensing	CaS	Homo sapiens	Ca	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	chim(NtGi1-Gs-CtGq)/β1/γ2	3.4	2024-04-17	10.1038/s41586-024-07331-1
	9ASB (No Gprot)	C	Ion	Calcium Sensing	CaS	Homo sapiens	Ca	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4		3.4	2024-04-17	10.1038/s41586-024-07331-1
	9AVG	C	Ion	Calcium Sensing	CaS	Homo sapiens	Ca	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	chim(NtGi1-Gs)/β1/γ2	3.6	2024-04-17	10.1038/s41586-024-07331-1
	9AVG (No Gprot)	C	Ion	Calcium Sensing	CaS	Homo sapiens	Ca	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4		3.6	2024-04-17	10.1038/s41586-024-07331-1
	9AYF	C	Ion	Calcium Sensing	CaS	Homo sapiens	Ca	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	Gi1/β1/γ2	3.6	2024-04-17	10.1038/s41586-024-07331-1
	9AYF (No Gprot)	C	Ion	Calcium Sensing	CaS	Homo sapiens	Ca	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4		3.6	2024-04-17	10.1038/s41586-024-07331-1
	9AVL	C	Ion	Calcium Sensing	CaS	Homo sapiens	Ca	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	Gi3/β2/γ2	3.8	2024-04-17	10.1038/s41586-024-07331-1
	9AVL (No Gprot)	C	Ion	Calcium Sensing	CaS	Homo sapiens	Ca	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4		3.8	2024-04-17	10.1038/s41586-024-07331-1
	8SZF	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	-	2.8	2024-02-07	10.1038/s41586-024-07055-2
	8SZG	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	chim(NtGi1-Gq)/β1/γ2	3.6	2024-02-07	10.1038/s41586-024-07055-2
	8SZG (No Gprot)	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW		3.6	2024-02-07	10.1038/s41586-024-07055-2
	8SZH	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	Gi1/β1/γ2	3.1	2024-02-07	10.1038/s41586-024-07055-2
	8SZH (No Gprot)	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW		3.1	2024-02-07	10.1038/s41586-024-07055-2
	8SZI	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	Gi3/β1/γ2	3.5	2024-02-07	10.1038/s41586-024-07055-2
	8SZI (No Gprot)	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW		3.5	2024-02-07	10.1038/s41586-024-07055-2
	8WPG	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Tryptophan; Cinacalcet; PO4; Ca	-	2.7	2023-11-22	10.1038/s41422-023-00892-2
	8WPU	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Tryptophan; Cinacalcet; PO4; Ca	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.1	2023-11-22	10.1038/s41422-023-00892-2
	8WPU (No Gprot)	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Tryptophan; Cinacalcet; PO4; Ca		3.1	2023-11-22	10.1038/s41422-023-00892-2
	7SIN	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	NPS-2143	-	5.9	2022-01-19	10.1073/pnas.2115849118
	7SIM	C	Ion	Calcium Sensing	CaS	Homo sapiens	Ca	Ca; Ca; Cyclomethyltryptophan; PO4	-	2.7	2022-01-19	10.1073/pnas.2115849118
	7SIL	C	Ion	Calcium Sensing	CaS	Homo sapiens	Ca	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	-	2.7	2022-01-19	10.1073/pnas.2115849118
	7E6U	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	-	-	6	2021-09-22	10.7554/eLife.68578
	7E6T	C	Ion	Calcium Sensing	CaS	Homo sapiens	Ca	Ca; Ca; Cyclomethyltryptophan; PO4	-	3	2021-09-22	10.7554/eLife.68578
	7M3J	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	NPS-2143; PO4	-	4.1	2021-06-30	10.1038/s41586-021-03691-0
	7M3G	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	-	2.5	2021-06-30	10.1038/s41586-021-03691-0
	7M3F	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4	-	2.8	2021-06-30	10.1038/s41586-021-03691-0
	7M3E	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; NPS-2143	-	3.2	2021-06-30	10.1038/s41586-021-03691-0
	7DD7	C	Ion	Calcium Sensing	CaS	Gallus gallus	Ca	Ca; Ca; Tryptophan; Evocalcet	-	3.2	2021-06-16	10.1126/sciadv.abg1483
	7DD6	C	Ion	Calcium Sensing	CaS	Gallus gallus	Ca	Ca; Ca; Tryptophan	-	3.2	2021-06-16	10.1126/sciadv.abg1483
	7DD5	C	Ion	Calcium Sensing	CaS	Gallus gallus	Ca	Ca; Ca; Tryptophan; NPS-2143	-	3.2	2021-06-16	10.1126/sciadv.abg1483
	7DTW	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	-	-	4.5	2021-03-10	10.1038/s41422-021-00474-0
	7DTV	C	Ion	Calcium Sensing	CaS	Homo sapiens	Ca	Ca; Tryptophan	-	3.5	2021-03-10	10.1038/s41422-021-00474-0
	7DTU	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Tryptophan	-	4.4	2021-03-10	10.1038/s41422-021-00474-0
	7DTT	C	Ion	Calcium Sensing	CaS	Homo sapiens	Ca	Ca	-	3.8	2021-03-10	10.1038/s41422-021-00474-0

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8WPU_nogp.zip

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