Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1H:H:?1 15.5233630
2H:H:?3 16.92336110
3H:H:?8 15.9475400
4H:H:?11 13.4685220
5H:H:?13 15.11254230
6R:R:Y20 7.55482
7R:R:F38 7.44427
8R:R:P39 5.5725426
9R:R:I40 6.91425
10R:R:H41 7.48333627
11R:R:F42 11.514293
12R:R:L51 6.4025406
13R:R:Y63 7.95429725
14R:R:N64 8.1275404
15R:R:F65 8.83422
16R:R:R66 9.302525
17R:R:F68 8.796527
18R:R:R69 8.974528
19R:R:W70 7.21222925
20R:R:Q72 7.6575427
21R:R:M74 5.7428
22R:R:Y95 8.838528
23R:R:R96 5.48333684
24R:R:I97 6.605428
25R:R:F98 7.70667684
26R:R:D99 6.81429
27R:R:C101 5.6575428
28R:R:K106 2.7575424
29R:R:E109 4.3875485
30R:R:F114 5.08833685
31R:R:Q117 7.81406
32R:R:L123 4.5225405
33R:R:I135 5.4775404
34R:R:T145 6.37333625
35R:R:N155 5.5275455
36R:R:I162 4.1975406
37R:R:P163 4.476508
38R:R:Q164 5.624508
39R:R:S166 4.3625459
40R:R:Y167 7.686528
41R:R:L173 6.5425305
42R:R:L174 7.8457
43R:R:Q179 7.0375455
44R:R:F180 6.3775455
45R:R:F183 8.58558
46R:R:R185 5.706559
47R:R:I187 4.854316
48R:R:F204 8.322567
49R:R:W206 8.815469
50R:R:W208 10.5433699
51R:R:V209 3.834568
52R:R:T211 6.1925405
53R:R:D215 6.87406
54R:R:Y218 5.40833607
55R:R:K225 8.9025403
56R:R:E229 7.74405
57R:R:R233 6.56504
58R:R:I235 4.3975467
59R:R:D238 8.5325498
60R:R:F239 4.86667696
61R:R:I243 4.0754335
62R:R:V255 4.80754335
63R:R:V266 4.985467
64R:R:V268 5.6725406
65R:R:F270 5.424507
66R:R:P274 4.10254293
67R:R:E277 4.665402
68R:R:E282 5.574186
69R:R:R286 6.3565184
70R:R:W299 8.1985137
71R:R:I305 4.52254134
72R:R:Y310 6.064143
73R:R:F311 9.98403
74R:R:V313 4.94254143
75R:R:F320 5.5645326
76R:R:I327 5.934526
77R:R:F330 7.758528
78R:R:R331 8.5375424
79R:R:L334 8.9825426
80R:R:N345 3.87286728
81R:R:F347 6.2625425
82R:R:F351 6.88667626
83R:R:T355 4.73754194
84R:R:F356 9.1554198
85R:R:L360 5.145404
86R:R:E399 6.014198
87R:R:Y408 8.626523
88R:R:Y411 8.6975425
89R:R:L414 7.025426
90R:R:I416 8.37424
91R:R:S417 5.3725426
92R:R:Y418 6.61333627
93R:R:Y421 9.974528
94R:R:Q432 4.655407
95R:R:Y435 5.335403
96R:R:F444 6.0575403
97R:R:W458 7.836676354
98R:R:Q459 7.85254357
99R:R:K462 6.7825404
100R:R:H463 9.175405
101R:R:L464 3.395407
102R:R:R465 6.235405
103R:R:N471 4.032526
104R:R:D484 5.176558
105R:R:N488 9.70254224
106R:R:Y489 3.974328
107R:R:I491 4.915408
108R:R:W494 6.777147137
109R:R:S497 3.822503
110R:R:I503 4.074134
111R:R:Y511 8.1575405
112R:R:N512 8.88254224
113R:R:Y514 8.7254224
114R:R:I523 5.2875466
115R:R:W530 8.03768
116R:R:F563 7.62754157
117R:R:W590 5.365406
118R:R:W608 4.875405
119R:R:V630 4.6525477
120R:R:F634 5.265479
121R:R:I635 4.3175474
122R:R:R648 4.5875408
123R:R:L650 4.894248
124R:R:Y652 4.532577
125R:R:L654 4.9725408
126R:R:F668 8.4725409
127R:R:R678 6.015405
128R:R:F684 9.37608
129R:R:C691 4.0654388
130R:R:I695 4.0975407
131R:R:F706 4.985409
132R:R:Q724 9.6254248
133R:R:V728 5.195407
134R:R:Q735 8.2565409
135R:R:W742 6.832509
136R:R:Y751 6.6654413
137R:R:N753 7.734417
138R:R:F762 6.86407
139R:R:I763 5.85254377
140R:R:Y779 8.23754409
141R:R:C787 4.0475408
142R:R:F790 5.7325407
143R:R:L797 4.475408
144R:R:F801 4.275409
145R:R:F814 7.85399
146R:R:F821 5.12833609
147R:R:V838 4.4975407
148R:R:F853 6.89167679
149S:S:F38 6.722517
150S:S:H41 6.48833617
151S:S:F42 11.3154443
152S:S:D50 5.16403
153S:S:C60 5.325417
154S:S:Y63 7.50143715
155S:S:F65 7.682512
156S:S:R66 8.85415
157S:S:F68 7.855617
158S:S:R69 7.3425418
159S:S:W70 7.54625815
160S:S:Q72 8.9025417
161S:S:M74 5.39418
162S:S:F76 7.176517
163S:S:L87 5.215416
164S:S:Y95 8.35518
165S:S:R96 6.8354164
166S:S:I97 5.51518
167S:S:F98 7.8756164
168S:S:D99 7.4725419
169S:S:C101 6.0625418
170S:S:F114 5.49254165
171S:S:I139 3.69754435
172S:S:T145 5.96333615
173S:S:T151 4.7675445
174S:S:N155 5.42445
175S:S:P163 3.728508
176S:S:Q164 6.73508
177S:S:V165 3.2154456
178S:S:Y167 7.868518
179S:S:L173 6.91405
180S:S:L174 7.194547
181S:S:F180 6.9775445
182S:S:F183 7.21833648
183S:S:R185 6.184549
184S:S:I187 5.2775416
185S:S:P188 3.9875418
186S:S:Q193 7.205619
187S:S:D199 7.574517
188S:S:F204 7.588517
189S:S:W206 8.446519
190S:S:W208 6.9625839
191S:S:V209 3.905418
192S:S:D217 3.8325446
193S:S:Y218 6.315617
194S:S:K225 9.24403
195S:S:R227 7.4225404
196S:S:E229 9.115415
197S:S:R233 8.788514
198S:S:D238 7.26438
199S:S:F239 5.586536
200S:S:V266 7.355417
201S:S:F270 6.8725417
202S:S:P274 4.8625443
203S:S:D275 3.9175405
204S:S:I283 4.4775404
205S:S:R286 5.0325404
206S:S:I292 4.1875417
207S:S:W293 6.88438
208S:S:W299 8.275177
209S:S:I305 4.948336174
210S:S:Y310 7.4285463
211S:S:F311 9.695403
212S:S:F320 6.232516
213S:S:A321 3.395405
214S:S:L322 5.805414
215S:S:I327 5.348516
216S:S:F330 6.814518
217S:S:F333 9.7275417
218S:S:N345 4.502518
219S:S:F351 8.76667616
220S:S:W352 13.51418
221S:S:T355 5.71414
222S:S:F356 11.6275418
223S:S:Y408 8.495813
224S:S:Y411 10.9425405
225S:S:I416 7.45414
226S:S:Y418 6.04517
227S:S:Y421 6.8375418
228S:S:Y425 5.74518
229S:S:I427 4.4825405
230S:S:F444 4.123336103
231S:S:T445 3.3875401
232S:S:E456 7.61754105
233S:S:W458 11.5145104
234S:S:Q459 8.3825107
235S:S:K462 8.23254104
236S:S:H463 7.33405
237S:S:L464 3.715407
238S:S:N471 6.6825416
239S:S:M473 5.14514
240S:S:F479 5.935408
241S:S:D484 4.6675448
242S:S:Y489 4.564518
243S:S:W494 7.101676177
244S:S:S497 3.56503
245S:S:Y511 6.72615
246S:S:N512 4.57414
247S:S:V513 6.57413
248S:S:L521 4.79515
249S:S:E525 5.66514
250S:S:I528 6.5425417
251S:S:W530 8.9975818
252S:S:T550 5.52754486
253S:S:C561 5.65439
254S:S:C585 4.0825409
255S:S:D588 7.184206
256S:S:H595 6.8175405
257S:S:W608 4.3525405
258S:S:T646 5.8054509
259S:S:L654 6.125408
260S:S:F662 7.4875408
261S:S:F668 8.0225409
262S:S:I669 3.04408
263S:S:R678 7.19405
264S:S:R680 6.778508
265S:S:F684 11.3265128
266S:S:F688 6.686508
267S:S:V689 7.025407
268S:S:C691 5.2925408
269S:S:Q724 7.0775408
270S:S:Q735 7.214509
271S:S:W742 5.382509
272S:S:I761 6.9245207
273S:S:F762 5.0825407
274S:S:H766 3.74406
275S:S:F790 3.535407
276S:S:N800 5.755507
277S:S:K805 6.23754259
278S:S:F806 7.024255
279S:S:F809 5.78254259
280S:S:F814 7.6175409
281S:S:W818 10.2265129
282S:S:F821 7.86754129
283S:S:Y825 8.074129
284S:S:F832 7.3875405
285S:S:F853 6.224499
286W:W:W1 5.02820
287W:W:?2 12.5967620
288W:W:?4 11.63110390
289X:X:W1 6.57710
290X:X:?2 8.61167610
291X:X:?4 11.73878120
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:E191 R:R:K225 64.559714.85NoYes033
2R:R:E229 R:R:K225 64.446113.5YesYes053
3R:R:E229 R:R:R233 64.34993.49YesYes054
4R:R:I235 R:R:R233 62.07993.76YesYes074
5R:R:I235 R:R:V209 61.92093.07YesYes678
6R:R:G210 R:R:V209 62.15473.68NoYes088
7R:R:F239 R:R:G210 62.11799.03YesNo068
8R:R:D238 R:R:F239 1003.58YesYes986
9R:R:D238 R:R:W208 99.829920.1YesYes989
10R:R:P559 R:R:W208 99.09118.11NoYes069
11R:R:C236 R:R:P559 98.68263.77NoNo096
12R:R:C236 R:R:C561 98.49277.28NoNo1199
13R:R:C561 R:R:N207 98.42577.87NoNo1196
14H:H:?3 R:R:N207 98.026816.02YesNo1106
15H:H:?3 R:R:D545 97.61583.65YesNo005
16R:R:D545 R:R:D578 97.443714.64NoNo057
17R:R:D578 R:R:K552 96.83476.91NoNo1578
18R:R:K552 S:S:I554 96.848.72NoNo083
19R:R:I554 S:S:I554 96.49422.94NoNo033
20R:R:I554 S:S:K552 95.974318.9NoNo038
21S:S:F563 S:S:K552 95.800722.33NoNo078
22S:S:C546 S:S:F563 95.53994.19NoNo097
23S:S:C546 S:S:T550 95.34796.76NoYes4896
24S:S:E567 S:S:T550 95.19175.64NoYes046
25S:S:E567 S:S:H595 95.10467.39NoYes045
26R:R:D217 R:R:L173 38.47545.43NoYes065
27R:R:L173 R:R:S171 52.08574.5YesNo3057
28R:R:S147 R:R:S171 52.1054.89NoNo087
29R:R:S147 R:R:Y218 52.08535.09NoYes087
30R:R:A298 R:R:Y218 13.92534NoYes067
31R:R:A298 W:W:W1 13.8725.19NoYes060
32S:S:L157 S:S:Q164 10.66387.99NoYes078
33S:S:W70 X:X:?2 12.1939.17YesYes150
34S:S:T145 S:S:W70 28.35097.28YesYes155
35S:S:S147 X:X:W1 36.10936.18NoYes080
36S:S:S147 S:S:S171 36.15126.52NoNo087
37S:S:L174 S:S:S171 36.19414.5YesNo077
38S:S:F183 S:S:Q164 10.170410.54YesYes088
39R:R:L173 R:R:R172 36.41376.07YesNo054
40S:S:L174 S:S:T151 45.52615.9YesYes475
41S:S:D217 S:S:T151 46.04644.34YesYes465
42S:S:D217 S:S:R220 71.39333.57YesNo066
43S:S:D215 S:S:R220 21.03757.15NoNo066
44R:R:D216 R:R:Y218 34.68683.45NoYes067
45R:R:A214 R:R:D216 34.6553.09NoNo056
46R:R:A214 R:R:S271 40.53473.42NoNo054
47R:R:I243 R:R:S271 40.50673.1YesNo054
48R:R:I212 R:R:I243 40.16274.42NoYes065
49R:R:D217 R:R:R220 39.68843.57NoNo066
50R:R:D215 R:R:R220 19.90037.15YesNo066
51S:S:D217 S:S:L173 26.16484.07YesYes065
52S:S:L173 S:S:R172 45.07876.07YesNo054
53S:S:E191 S:S:R172 64.4089.3NoNo034
54S:S:H595 S:S:S591 90.60755.58YesNo058
55S:S:G571 S:S:S591 89.71373.71NoNo078
56S:S:G571 S:S:W590 89.62419.85NoNo076
57S:S:E759 S:S:W590 89.534413.08NoNo046
58S:S:E757 S:S:E759 89.3556.34NoNo044
59S:S:E757 S:S:I760 89.26525.47NoNo045
60S:S:F762 S:S:I760 89.08566.28YesNo075
61S:S:E604 S:S:F762 88.81584.66NoYes067
62S:S:E604 S:S:K831 88.72589.45NoNo069
63S:S:F832 S:S:K831 88.635812.41YesNo059
64S:S:F612 S:S:F832 52.183911.79NoYes085
65R:R:P823 S:S:F612 51.97415.78NoNo098
66R:R:I822 R:R:P823 51.65023.39NoNo079
67R:R:I822 W:W:?4 51.44894.17NoYes070
68R:R:F684 W:W:?4 19.908218.66YesYes080
69R:R:F684 R:R:F688 17.58247.5YesNo088
70R:R:F688 R:R:I692 34.7838.79NoNo087
71R:R:C787 R:R:I692 34.55413.27YesNo087
72R:R:C787 R:R:I695 31.3463.27YesYes087
73R:R:I695 R:R:L654 18.83944.28YesYes078
74R:R:F814 W:W:?4 17.95193.56YesYes3990
75R:R:F688 R:R:F814 17.432813.93NoYes089
76R:R:S827 S:S:F832 43.01913.96NoYes085
77R:R:S827 S:S:T828 42.91083.2NoNo088
78S:S:T828 S:S:V833 42.80256.35NoNo086
79S:S:V833 S:S:Y825 42.69415.05NoYes069
80S:S:Y825 X:X:?4 36.107810.27YesYes1290
81S:S:F684 X:X:?4 22.763919.55YesYes1280
82S:S:F684 S:S:F688 22.617610.72YesYes088
83S:S:R69 X:X:?2 13.11835.59YesYes180
84S:S:R69 S:S:Y408 24.07833.09YesYes183
85S:S:D199 S:S:T195 31.7194.34YesNo074
86S:S:E229 S:S:T195 31.872611.29YesNo054
87S:S:E229 S:S:K225 64.424410.8YesYes053
88S:S:D199 S:S:R233 31.778910.72YesYes174
89S:S:E229 S:S:R233 32.23999.3YesYes154
90S:S:E191 S:S:K225 64.833113.5NoYes033
91S:S:L521 S:S:Y203 30.17563.52YesNo155
92S:S:F204 S:S:Y203 29.76367.22YesNo175
93S:S:F204 S:S:W206 16.53811.02YesYes179
94S:S:I523 S:S:L521 30.17568.56NoYes165
95S:S:F204 S:S:I523 29.76365.02YesNo176
96S:S:E525 S:S:F204 19.01844.66YesYes147
97S:S:F204 S:S:W530 23.1510.02YesYes178
98S:S:E525 S:S:I528 13.23086.83YesYes147
99S:S:I528 S:S:N493 19.85454.25YesNo079
100S:S:I528 S:S:W530 13.24065.87YesYes178
101S:S:H495 S:S:N493 16.545810.2NoNo079
102S:S:H495 S:S:K506 13.2377.86NoNo075
103S:S:K506 S:S:V504 11.58253.04NoNo053
104S:S:F688 S:S:L848 18.10043.65YesNo087
105S:S:C691 S:S:L848 10.06076.35YesNo087
106S:S:C694 S:S:L654 11.43867.94NoYes068
107S:S:C694 S:S:L650 16.694.76NoNo068
108R:R:E191 R:R:R172 57.38368.14NoNo034
109R:R:L173 S:S:R220 50.4438.5YesNo056
110S:S:T145 X:X:W1 32.80774.85YesYes150
111R:R:F239 R:R:I212 40.14363.77YesNo066
112R:R:R172 S:S:D215 21.042510.72NoNo046
113R:R:D215 S:S:R172 19.636610.72YesNo064
114R:R:R220 S:S:L173 19.893910.93NoYes065
115S:S:R66 S:S:W70 11.93748YesYes155
116S:S:R66 S:S:R69 12.92813.2YesYes158
117S:S:D199 S:S:L521 54.3324.07YesYes175
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:P39 S:S:W70 5.4 1 No Yes 6 5 2 2
S:S:P39 S:S:T145 8.74 1 No Yes 6 5 2 1
S:S:T145 S:S:W70 7.28 1 Yes Yes 5 5 1 2
S:S:W70 S:S:Y167 5.79 1 Yes Yes 5 8 2 2
S:S:G146 S:S:T145 3.64 1 No Yes 5 5 1 1
S:S:T145 S:S:Y167 6.24 1 Yes Yes 5 8 1 2
S:S:A168 S:S:T145 5.03 1 No Yes 5 5 1 1
S:S:T145 X:X:W1 4.85 1 Yes Yes 5 0 1 0
S:S:G146 S:S:V149 3.68 1 No No 5 4 1 2
S:S:G146 X:X:W1 4.22 1 No Yes 5 0 1 0
S:S:S147 S:S:S171 6.52 0 No No 8 7 1 2
S:S:S147 X:X:W1 6.18 0 No Yes 8 0 1 0
S:S:A168 X:X:W1 3.89 1 No Yes 5 0 1 0
S:S:I187 S:S:S170 4.64 1 Yes No 6 7 2 1
S:S:D190 S:S:S170 10.31 0 No No 8 7 2 1
S:S:S170 X:X:W1 4.94 0 No Yes 7 0 1 0
S:S:D190 S:S:Y218 5.75 0 No Yes 8 7 2 1
S:S:D216 S:S:Y218 3.45 0 No Yes 6 7 2 1
S:S:S296 S:S:Y218 6.36 1 No Yes 8 7 2 1
S:S:A298 S:S:Y218 4 1 No Yes 6 7 1 1
S:S:Y218 X:X:W1 15.43 1 Yes Yes 7 0 1 0
S:S:A298 X:X:W1 6.48 1 No Yes 6 0 1 0
S:S:G219 S:S:Y218 2.9 0 No Yes 7 7 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F684 S:S:S664 5.28 12 Yes No 8 6 1 2
S:S:F668 S:S:R680 13.9 0 Yes Yes 9 8 2 2
S:S:E837 S:S:F668 10.49 12 No Yes 9 9 1 2
S:S:F668 S:S:I841 3.77 0 Yes No 9 9 2 2
S:S:Q681 S:S:R680 7.01 0 No Yes 9 8 1 2
S:S:L773 S:S:Q681 5.32 0 No No 8 9 2 1
S:S:Q681 X:X:?4 7.77 0 No Yes 9 0 1 0
S:S:F684 S:S:F688 10.72 12 Yes Yes 8 8 1 2
S:S:F684 S:S:W818 6.01 12 Yes Yes 8 9 1 1
S:S:F684 S:S:I841 15.07 12 Yes No 8 9 1 2
S:S:F684 X:X:?4 19.55 12 Yes Yes 8 0 1 0
S:S:F688 S:S:F814 7.5 0 Yes Yes 8 9 2 2
S:S:T780 S:S:V689 3.17 0 No Yes 7 7 1 2
S:S:E767 S:S:L770 7.95 0 No No 7 3 2 1
S:S:L770 X:X:?4 6.06 0 No Yes 3 0 1 0
S:S:I777 X:X:?4 18.75 0 No Yes 8 0 1 0
S:S:T780 X:X:?4 6.45 0 No Yes 7 0 1 0
S:S:F814 S:S:W818 7.02 0 Yes Yes 9 9 2 1
S:S:F821 S:S:W818 12.03 12 Yes Yes 9 9 2 1
S:S:A840 S:S:W818 7.78 12 No Yes 9 9 2 1
S:S:W818 X:X:?4 18.29 12 Yes Yes 9 0 1 0
S:S:F821 S:S:Y825 11.35 12 Yes Yes 9 9 2 1
S:S:A840 S:S:F821 4.16 12 No Yes 9 9 2 2
S:S:V833 S:S:Y825 5.05 0 No Yes 6 9 2 1
S:S:E837 S:S:Y825 5.61 12 No Yes 9 9 1 1
S:S:Y825 X:X:?4 10.27 12 Yes Yes 9 0 1 0
S:S:E837 X:X:?4 6.77 12 No Yes 9 0 1 0
S:S:C781 S:S:I777 1.64 0 No No 7 8 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:N64 R:R:P39 3.26 0 Yes Yes 4 6 2 2
R:R:P39 R:R:W70 5.4 2 Yes Yes 6 5 2 1
R:R:P39 R:R:T145 8.74 2 Yes Yes 6 5 2 1
R:R:N64 R:R:R66 3.62 0 Yes Yes 4 5 2 1
R:R:G67 R:R:N64 5.09 0 No Yes 4 4 2 2
R:R:R66 R:R:R69 5.33 2 Yes Yes 5 8 1 2
R:R:R66 R:R:W70 7 2 Yes Yes 5 5 1 1
R:R:R66 W:W:W1 4 2 Yes Yes 5 0 1 0
R:R:R66 W:W:?2 26.56 2 Yes Yes 5 0 1 2
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:R69 R:R:S417 6.59 2 Yes Yes 8 6 2 2
R:R:R69 W:W:?2 16.77 2 Yes Yes 8 0 2 2
R:R:T145 R:R:W70 7.28 2 Yes Yes 5 5 1 1
R:R:W70 R:R:Y167 3.86 2 Yes Yes 5 8 1 2
R:R:I416 R:R:W70 12.92 2 Yes Yes 4 5 1 1
R:R:S417 R:R:W70 3.71 2 Yes Yes 6 5 2 1
R:R:W70 W:W:W1 4.69 2 Yes Yes 5 0 1 0
R:R:W70 W:W:?2 14.42 2 Yes Yes 5 0 1 2
R:R:G146 R:R:T145 3.64 0 No Yes 5 5 2 1
R:R:T145 R:R:Y167 7.49 2 Yes Yes 5 8 1 2
R:R:A168 R:R:T145 5.03 2 No Yes 5 5 1 1
R:R:T145 W:W:W1 6.06 2 Yes Yes 5 0 1 0
R:R:I416 R:R:Y167 4.84 2 Yes Yes 4 8 1 2
R:R:A168 W:W:W1 5.19 2 No Yes 5 0 1 0
R:R:E297 R:R:Q193 5.1 0 No No 8 9 1 2
R:R:A298 R:R:Y218 4 0 No Yes 6 7 1 2
R:R:D275 R:R:S272 7.36 0 No No 5 5 2 1
R:R:S272 W:W:W1 3.71 0 No Yes 5 0 1 0
R:R:E297 R:R:L322 10.6 0 No No 8 4 1 2
R:R:E297 W:W:W1 5.45 0 No Yes 8 0 1 0
R:R:A298 W:W:W1 5.19 0 No Yes 6 0 1 0
R:R:I416 W:W:W1 5.87 2 Yes Yes 4 0 1 0
R:R:I416 W:W:?2 9.85 2 Yes Yes 4 0 1 2
R:R:S417 W:W:?2 5.18 2 Yes Yes 6 0 2 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C661 R:R:F684 4.19 0 No Yes 7 8 2 1
R:R:F684 R:R:S664 5.28 0 Yes No 8 6 1 2
R:R:E837 R:R:F668 9.33 0 No Yes 9 9 1 2
R:R:F668 R:R:I841 3.77 0 Yes No 9 9 2 2
R:R:Q681 R:R:W742 6.57 0 No Yes 9 9 1 2
R:R:L773 R:R:Q681 13.31 0 No No 8 9 2 1
R:R:Q681 W:W:?4 6.8 0 No Yes 9 0 1 0
R:R:F684 R:R:F688 7.5 0 Yes No 8 8 1 2
R:R:F684 R:R:I841 17.58 0 Yes No 8 9 1 2
R:R:F684 W:W:?4 18.66 0 Yes Yes 8 0 1 0
R:R:F688 R:R:F814 13.93 0 No Yes 8 9 2 1
R:R:L776 R:R:Q735 10.65 0 No Yes 8 9 1 2
R:R:Q735 R:R:T780 5.67 40 Yes No 9 7 2 1
R:R:I738 R:R:L776 4.28 0 No No 8 8 2 1
R:R:I777 R:R:L773 4.28 0 No No 8 8 1 2
R:R:L776 W:W:?4 4.04 0 No Yes 8 0 1 0
R:R:G778 R:R:I777 3.53 0 No No 5 8 2 1
R:R:I777 W:W:?4 16.66 0 No Yes 8 0 1 0
R:R:T780 W:W:?4 6.45 0 No Yes 7 0 1 0
R:R:F814 R:R:F815 10.72 39 Yes No 9 7 1 2
R:R:F814 R:R:W818 8.02 39 Yes No 9 9 1 1
R:R:F814 W:W:?4 3.56 39 Yes Yes 9 0 1 0
R:R:A840 R:R:W818 7.78 0 No No 9 9 2 1
R:R:W818 W:W:?4 33.25 39 No Yes 9 0 1 0
R:R:I822 R:R:P823 3.39 0 No No 7 9 1 2
R:R:I822 W:W:?4 4.17 0 No Yes 7 0 1 0
R:R:Y825 W:W:?4 11.12 0 No Yes 9 0 1 0
R:R:E837 W:W:?4 11.6 0 No Yes 9 0 1 0
R:R:F684 R:R:G685 3.01 0 Yes No 8 8 1 2
R:R:A844 R:R:F814 2.77 0 No Yes 9 9 2 1
R:R:I819 R:R:I822 1.47 0 No No 6 7 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8WPU_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.07
Number of Linked Nodes 1582
Number of Links 1906
Number of Hubs 291
Number of Links mediated by Hubs 1076
Number of Communities 50
Number of Nodes involved in Communities 416
Number of Links involved in Communities 586
Path Summary
Number Of Nodes in MetaPath 118
Number Of Links MetaPath 117
Number of Shortest Paths 8106132
Length Of Smallest Path 3
Average Path Length 47.09
Length of Longest Path 89
Minimum Path Strength 1.22
Average Path Strength 7.47478
Maximum Path Strength 33.845
Minimum Path Correlation 0.7
Average Path Correlation 0.999297
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2
Average % Of Corr. Nodes 64.9525
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.8645
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • amino acid binding   • identical protein binding   • protein binding   • cation binding   • ion binding   • calcium ion binding   • metal ion binding   • small molecule binding   • phosphoric ester hydrolase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • phospholipase C activity   • hydrolase activity   • phosphatidylinositol-4,5-bisphosphate phospholipase C activity   • catalytic activity   • phospholipase activity   • lipase activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • transmembrane transporter binding   • cell adhesion molecule binding   • protein-containing complex binding   • integrin binding   • signaling receptor binding   • protein homodimerization activity   • protein dimerization activity   • kinase binding   • enzyme binding   • protein kinase binding   • biological regulation   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • regulation of biological process   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization
Gene OntologyBiological Process• biological regulation   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • regulation of biological process   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • developmental process   • multicellular organismal process   • epithelium development   • tube development   • branching morphogenesis of an epithelial tube   • morphogenesis of an epithelium   • tissue development   • tissue morphogenesis   • anatomical structure morphogenesis   • multicellular organism development   • tube morphogenesis   • morphogenesis of a branching structure   • anatomical structure development   • epithelial tube morphogenesis   • morphogenesis of a branching epithelium   • regulation of tube diameter   • system process   • regulation of tube size   • regulation of system process   • positive regulation of biological process   • positive regulation of vasoconstriction   • circulatory system process   • regulation of blood circulation   • vascular process in circulatory system   • regulation of vasoconstriction   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • blood vessel diameter maintenance   • vasoconstriction   • blood circulation   • regulation of anatomical structure size   • monoatomic ion transmembrane transport   • chloride transport   • transmembrane transport   • chloride transmembrane transport   • monoatomic anion transport   • monoatomic anion transmembrane transport   • cellular process   • inorganic anion transport   • regulation of biosynthetic process   • regulation of cellular process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • response to stimulus   • response to stress   • response to ischemia   • response to decreased oxygen levels   • cellular response to stimulus   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to chemical stimulus   • cellular response to stress   • response to hypoxia   • response to chemical   • response to oxygen levels   • response to abiotic stimulus   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • organic acid transport   • bile acid secretion   • organic anion transport   • monocarboxylic acid transport   • carboxylic acid transport   • secretion   • acid secretion   • response to peptide   • cellular response to peptide   • behavior   • chemosensory behavior   • signaling   • intracellular signal transduction   • cell communication   • JNK cascade   • intracellular signaling cassette   • MAPK cascade   • signal transduction   • cellular response to low-density lipoprotein particle stimulus   • response to endogenous stimulus   • response to lipoprotein particle   • response to nitrogen compound   • cellular response to lipoprotein particle stimulus   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • regulation of calcium ion import   • positive regulation of calcium ion transport   • positive regulation of calcium ion import   • positive regulation of transport   • positive regulation of monoatomic ion transport   • calcium ion import   • ossification   • connective tissue development   • adipose tissue development   • fat pad development   • animal organ development   • response to fibroblast growth factor   • response to growth factor   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • response to oxygen-containing compound   • cellular response to glucose stimulus   • intracellular glucose homeostasis   • cellular response to oxygen-containing compound   • response to hexose   • cellular response to carbohydrate stimulus   • response to monosaccharide   • response to carbohydrate   • response to glucose   • glucose homeostasis   • carbohydrate homeostasis   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • response to nutrient levels   • response to lipid   • response to nutrient   • response to vitamin   • cellular response to vitamin D   • cellular response to nutrient levels   • response to vitamin D   • cellular response to vitamin   • cellular response to lipid   • cellular response to nutrient   • cell population proliferation   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • vasodilation   • positive chemotaxis   • chemotaxis   • positive regulation of locomotion   • regulation of response to external stimulus   • positive regulation of positive chemotaxis   • response to external stimulus   • regulation of chemotaxis   • positive regulation of chemotaxis   • regulation of positive chemotaxis   • positive regulation of response to external stimulus   • taxis   • regulation of locomotion   • locomotion   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular response to endogenous stimulus   • response to hepatocyte growth factor   • cellular response to growth factor stimulus   • cellular response to hepatocyte growth factor stimulus   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • positive regulation of insulin secretion   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • regulation of protein secretion   • regulation of secretion   • positive regulation of protein localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • positive regulation of secretion   • amide transport   • signal release   • positive regulation of peptide secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • detection of stimulus   • response to metal ion   • detection of chemical stimulus   • detection of calcium ion   • response to calcium ion   • cell periphery   • presynapse   • cellular anatomical structure   • synapse   • cell junction   • membrane   • plasma membrane   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse
Gene OntologyCellular Component• cell periphery   • presynapse   • cellular anatomical structure   • synapse   • cell junction   • membrane   • plasma membrane   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse   • somatodendritic compartment   • cell body   • neuronal cell body   • apical part of cell   • apical plasma membrane   • cell surface   • axon   • neuron projection   • axon terminus   • plasma membrane bounded cell projection   • cell projection   • distal axon   • neuron projection terminus   • binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • cation binding   • metal ion binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • D1 dopamine receptor binding   • dopamine receptor binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • regulation of biological process   • cell population proliferation   • regulation of cellular process   • positive regulation of cell population proliferation   • biological regulation   • positive regulation of biological process   • positive regulation of neural precursor cell proliferation   • regulation of cell population proliferation   • cellular process   • neural precursor cell proliferation   • positive regulation of cellular process   • regulation of neural precursor cell proliferation   • reactive oxygen species metabolic process   • regulation of superoxide metabolic process   • positive regulation of reactive oxygen species metabolic process   • superoxide metabolic process   • positive regulation of metabolic process   • superoxide anion generation   • metabolic process   • positive regulation of superoxide anion generation   • regulation of superoxide anion generation   • regulation of metabolic process   • regulation of reactive oxygen species metabolic process   • regulation of calcium ion transport   • regulation of localization   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • cellular response to stimulus   • positive regulation of cell communication   • positive regulation of signal transduction   • response to stimulus   • signaling   • regulation of signal transduction   • intracellular signal transduction   • cell communication   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • intracellular signaling cassette   • signal transduction   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • negative regulation of signaling   • negative regulation of biological process   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • negative regulation of cellular process   • regulation of G protein-coupled receptor signaling pathway   • adenylate cyclase-activating adrenergic receptor signaling pathway   • negative regulation of response to stimulus   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • negative regulation of signal transduction   • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell division   • regulation of body fluid levels   • multicellular organismal process   • renal system process   • system process   • positive regulation of urine volume   • regulation of urine volume   • regulation of biological quality   • regulation of vascular associated smooth muscle cell proliferation   • positive regulation of vascular associated smooth muscle cell proliferation   • regulation of smooth muscle cell proliferation   • smooth muscle cell proliferation   • positive regulation of smooth muscle cell proliferation   • muscle cell proliferation   • vascular associated smooth muscle cell proliferation   • cell-cell signaling   • gamma-aminobutyric acid signaling pathway   • purinergic nucleotide receptor signaling pathway   • cell surface receptor signaling pathway   • G protein-coupled purinergic receptor signaling pathway   • G protein-coupled adenosine receptor signaling pathway   • regulation of molecular function   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • regulated exocytosis   • regulation of calcium ion-dependent exocytosis   • negative regulation of transport   • negative regulation of regulated secretory pathway   • vesicle-mediated transport   • regulation of regulated secretory pathway   • secretion by cell   • regulation of secretion by cell   • negative regulation of secretion   • negative regulation of exocytosis   • negative regulation of secretion by cell   • calcium-ion regulated exocytosis   • secretion   • negative regulation of calcium ion-dependent exocytosis   • export from cell   • regulation of vesicle-mediated transport   • regulation of secretion   • exocytosis   • regulation of exocytosis   • regulation of programmed cell death   • negative regulation of apoptotic signaling pathway   • negative regulation of programmed cell death   • regulation of apoptotic process   • cell death   • apoptotic signaling pathway   • negative regulation of apoptotic process   • apoptotic process   • programmed cell death   • regulation of apoptotic signaling pathway   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of cell migration   • regulation of locomotion   • positive regulation of cell motility   • regulation of cell migration   • cell migration   • cell motility   • locomotion   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • trans-synaptic signaling   • modulation of chemical synaptic transmission   • negative regulation of synaptic transmission   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • cellular response to nitrogen compound   • cellular response to acetylcholine   • response to oxygen-containing compound   • response to nitrogen compound   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • G protein-coupled acetylcholine receptor signaling pathway   • response to chemical   • response to acetylcholine   • response to nutrient levels   • response to nutrient   • developmental process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • response to hormone   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • regulation of protein transport   • protein secretion   • regulation of protein secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • midbody   • membrane-bounded organelle   • intracellular anatomical structure   • dense core granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle   • organelle   • secretory granule   • secretory vesicle   • cytoplasm   • vesicle   • neuronal dense core vesicle   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • membraneless organelle   • intracellular membraneless organelle   • microtubule cytoskeleton   • cytosol   • dendrite   • dendritic tree   • nucleus   • membrane-enclosed lumen   • intracellular organelle lumen   • nucleoplasm   • organelle lumen   • nuclear lumen   • neuron to neuron synapse   • hippocampal mossy fiber to CA3 synapse   • cilium   • ciliary basal body   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network   • organelle membrane   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • phospholipase C-activating G protein-coupled receptor signaling pathway   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Type 1 solute binding protein-like   • TNF receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Type 1 solute binding protein-like   • TNF receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8 H:H:?9 H:H:?10 H:H:?11 H:H:?12 H:H:?13
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylglucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodeCA
PDB ResiduesI:I:?1 I:I:?2 W:W:?3 X:X:?3
Environment DetailsOpen EMBL-EBI Page
CodeCA
NameCALCIUM ION
Synonyms
Identifier
FormulaCa
Molecular Weight40.078
SMILES
PubChem
Formal Charge2
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

CodePO4
PDB ResiduesW:W:?2 X:X:?2
Environment DetailsOpen EMBL-EBI Page
CodePO4
NamePhosphate ion
Synonyms
  • Orthophosphate
  • Phosphate ion
  • Phosphate
Identifier
FormulaO4 P
Molecular Weight94.971
SMILES
PubChem1061
Formal Charge-3
Total Atoms5
Total Chiral Atoms0
Total Bonds4
Total Aromatic Bonds0

CodeYP4
PDB ResiduesW:W:?4 X:X:?4
Environment DetailsOpen EMBL-EBI Page
CodeYP4
NameCinacalcet
Synonyms
  • (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine
  • Cinacalcet
  • Cinacalcet hydrochloride
  • CNC
  • N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine
Identifier
FormulaC22 H22 F3 N
Molecular Weight357.412
SMILES
PubChem156419
Formal Charge0
Total Atoms48
Total Chiral Atoms1
Total Bonds50
Total Aromatic Bonds17

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41180
Sequence
>8WPU_nogp_Chain_R
YGPDQRAQK KGDIILGGL FPIHFGVAA KDQDLKSRP ESVECIRYN 
FRGFRWLQA MIFAIEEIN SSPALLPNL TLGYRIFDT CNTVSKALE 
ATLSFVAQN KIDSLNLDC SEHIPSTIA VVGATGSGV STAVANLLG 
LFYIPQVSY ASSSRLLSN KNQFKSFLR TIPNDEHQA TAMADIIEY 
FRWNWVGTI AADDDYGRP GIEKFREEA EERDICIDF SELISQYSD 
EEEIQHVVE VIQNSTAKV IVVFSSGPD LEPLIKEIV RRNITGKIW 
LASEAWASS SLIAMPQYF HVVGGTIGF ALKAGQIPG FREFLKKVH 
PRKSVHNGF AKEFWEETF NCHLQRPLC TGDENISSV ETPYIDYTH 
LRISYNVYL AVYSIAHAL QDIYTCLPG RGLFTNGSC ADIKKVEAW 
QVLKHLRHL NFTNNMGEQ VTFDECGDL VGNYSIINW HLSPEDGSI 
VFKEVGYYN VYAKKGERL FINEEKILW SGFSREVPF SNCSRDCLA 
GTRKGIIEG EPTCCFECV ECPDGEYSD ETDASACNK CPDDFWSNE 
NHTSCIAKE IEFLSWTEP FGIALTLFA VLGIFLTAF VLGVFIKFR 
NTPIVKATN RELSYLLLF SLLCCFSSS LFFIGEPQD WTCRLRQPA 
FGISFVLCI SCILVKTNR VLLVFEAKW GLNLQFLLV FLCTFMQIV 
ICVIWLYTA PPSSYRNQE LEDEIIFIT CHEGSLMAL GFLIGYTCL 
LAAICFFFA FKSRKLPEN FNEAKFITF SMLIFFIVW ISFIPAYAS 
TYGKFVSAV EVIAILAAS FGLLACIFF NKIYIILFK PS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP41180
Sequence
>8WPU_nogp_Chain_S
YGPDQRAQK KGDIILGGL FPIHFGVAA KDQDLKSRP ESVECIRYN 
FRGFRWLQA MIFAIEEIN SSPALLPNL TLGYRIFDT CNTVSKALE 
ATLSFVAQN KIDSLNLCS EHIPSTIAV VGATGSGVS TAVANLLGL 
FYIPQVSYA SSSRLLSNK NQFKSFLRT IPNDEHQAT AMADIIEYF 
RWNWVGTIA ADDDYGRPG IEKFREEAE ERDICIDFS ELISQYSDE 
EEIQHVVEV IQNSTAKVI VVFSSGPDL EPLIKEIVR RNITGKIWL 
ASEAWASSS LIAMPQYFH VVGGTIGFA LKAGQIPGF REFLKKVHP 
RKSVHNGFA KEFWEETFN CHLQFRPLC TGDENISSV ETPYIDYTH 
LRISYNVYL AVYSIAHAL QDIYTCLPG RGLFTNGSC ADIKKVEAW 
QVLKHLRHL NFTNNMGEQ VTFDECGDL VGNYSIINW HLSPEDGSI 
VFKEVGYYN VYAKKGERL FINEEKILW SGFSREVPF SNCSRDCLA 
GTRKGIIEG EPTCCFECV ECPDGEYSD ETDASACNK CPDDFWSNE 
NHTSCIAKE IEFLSWTEP FGIALTLFA VLGIFLTAF VLGVFIKFR 
NTPIVKATN RELSYLLLF SLLCCFSSS LFFIGEPQD WTCRLRQPA 
FGISFVLCI SCILVKTNR VLLVKWWGL NLQFLLVFL CTFMQIVIC 
VIWLYTAPP SSYRNQELE DEIIFITCH EGSLMALGF LIGYTCLLA 
AICFFFAFK SRKLPENFN EAKFITFSM LIFFIVWIS FIPAYASTY 
GKFVSAVEV IAILAASFG LLACIFFNK IYIILFKPS RNTIEEV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WPGCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca-2.72023-11-22doi.org/10.1038/s41422-023-00892-2
8WPUCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(NtGi2L-Gs-CtGq)/β1/γ23.12023-11-22doi.org/10.1038/s41422-023-00892-2
8WPU (No Gprot) CIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca3.12023-11-22doi.org/10.1038/s41422-023-00892-2
7DTUCIonCalcium SensingCaSHomo sapiens-Tryptophan-4.42021-03-10doi.org/10.1038/s41422-021-00474-0
7M3JCIonCalcium SensingCaSHomo sapiens-NPS-2143; PO4-4.12021-06-30doi.org/10.1038/s41586-021-03691-0
7SINCIonCalcium SensingCaSHomo sapiens-NPS-2143-5.92022-01-19doi.org/10.1073/pnas.2115849118
9C1PCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan; '6218; PO4-2.82024-10-02doi.org/10.1126/science.ado1868
7DTVCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan-3.52021-03-10doi.org/10.1038/s41422-021-00474-0
7M3ECIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; NPS-2143-3.22021-06-30doi.org/10.1038/s41586-021-03691-0
7DD5CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; NPS-2143-3.22021-06-16doi.org/10.1126/sciadv.abg1483
7M3GCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4-2.52021-06-30doi.org/10.1038/s41586-021-03691-0
7DD7CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; Evocalcet-3.22021-06-16doi.org/10.1126/sciadv.abg1483
8SZFCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-2.82024-02-07doi.org/10.1038/s41586-024-07055-2
8SZGCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Sperminechim(NtGi1-Gq)/β1/γ23.62024-02-07doi.org/10.1038/s41586-024-07055-2
8SZG (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine3.62024-02-07doi.org/10.1038/s41586-024-07055-2
8SZHCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; SpermineGi1/β1/γ23.12024-02-07doi.org/10.1038/s41586-024-07055-2
8SZH (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine3.12024-02-07doi.org/10.1038/s41586-024-07055-2
7M3FCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4-2.82021-06-30doi.org/10.1038/s41586-021-03691-0
8SZICIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4Gi3/β1/γ23.52024-02-07doi.org/10.1038/s41586-024-07055-2
8SZI (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO43.52024-02-07doi.org/10.1038/s41586-024-07055-2
9C2FCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Tryptophan; '54149; PO4-2.82024-10-02doi.org/10.1126/science.ado1868
7DD6CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan-3.22021-06-16doi.org/10.1126/sciadv.abg1483
7SIMCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-2.72022-01-19doi.org/10.1073/pnas.2115849118
7E6TCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-32021-09-22doi.org/10.7554/eLife.68578
9ASBCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.42024-04-17doi.org/10.1038/s41586-024-07331-1
9ASB (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.42024-04-17doi.org/10.1038/s41586-024-07331-1
9AVGCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs)/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AVG (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AVLCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4Gi3/β2/γ23.82024-04-17doi.org/10.1038/s41586-024-07331-1
9AVL (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.82024-04-17doi.org/10.1038/s41586-024-07331-1
9AXFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.52024-04-17doi.org/10.1038/s41586-024-07331-1
9AXF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.52024-04-17doi.org/10.1038/s41586-024-07331-1
9AYFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4Gi1/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AYF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-17doi.org/10.1038/s41586-024-07331-1
7SILCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-2.72022-01-19doi.org/10.1073/pnas.2115849118
7DTTCIonCalcium SensingCaSHomo sapiensCaCa-3.82021-03-10doi.org/10.1038/s41422-021-00474-0
7DTWCIonCalcium SensingCaSHomo sapiens---4.52021-03-10doi.org/10.1038/s41422-021-00474-0
7E6UCIonCalcium SensingCaSHomo sapiens---62021-09-22doi.org/10.7554/eLife.68578




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