Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1K:K:?1 7.323851340
2K:K:?2 6.301671240
3K:K:W5 3.43333610
4K:K:?6 9.842510
5R:R:Y20 4.65254212
6R:R:G30 2.31254289
7R:R:F38 4.864527
8R:R:I40 5.675425
9R:R:H41 7.1527
10R:R:F42 7.27754303
11R:R:V44 4.04422
12R:R:P55 6.6954126
13R:R:Y63 5.90429725
14R:R:F65 7.066522
15R:R:R66 9.275425
16R:R:F68 7.56427
17R:R:R69 5.64333628
18R:R:W70 7.61143725
19R:R:L71 3.56833624
20R:R:Q72 4.608527
21R:R:M74 3.19628
22R:R:F76 6.7125427
23R:R:I81 4.1625409
24R:R:L93 4.5375409
25R:R:Y95 7.508528
26R:R:I97 3.755628
27R:R:F98 8.568504
28R:R:C101 4.89428
29R:R:F114 3.982505
30R:R:I135 5.1425214
31R:R:T145 4.418525
32R:R:V153 4.514106
33R:R:L157 4.2665107
34R:R:F160 5.44667607
35R:R:P163 3.7775408
36R:R:Q164 5.4465108
37R:R:Y167 4.56667628
38R:R:S169 4.1325408
39R:R:R172 5.7825404
40R:R:L173 4.8375405
41R:R:L174 8.1054107
42R:R:F180 6.7454105
43R:R:F183 7.3565108
44R:R:R185 7.1065109
45R:R:I187 3.985406
46R:R:F204 7.7665137
47R:R:W206 6.6385139
48R:R:W208 6.18857739
49R:R:T211 4.1275405
50R:R:I212 3.235436
51R:R:D216 3.105426
52R:R:Y218 3.89727
53R:R:K225 5.8654333
54R:R:F226 4.1925406
55R:R:E229 5.44254335
56R:R:R233 6.778504
57R:R:F239 4.47333636
58R:R:V266 5.3485137
59R:R:V269 4.27435
60R:R:P274 3.366303
61R:R:D275 3.438525
62R:R:L276 6.1625435
63R:R:E277 7.4275402
64R:R:E282 7.6365226
65R:R:R286 5.111676224
66R:R:W293 4.76438
67R:R:W299 5.76737
68R:R:L304 4.41754302
69R:R:I305 4.006534
70R:R:F311 7.91403
71R:R:F320 3.855406
72R:R:I327 4.745426
73R:R:F330 7.148528
74R:R:L334 6.54333626
75R:R:H338 7.115404
76R:R:N345 3.6525428
77R:R:F347 4.2425425
78R:R:F351 8.255626
79R:R:E353 5.27254367
80R:R:T355 6.305424
81R:R:F356 9.734528
82R:R:L360 6.824364
83R:R:R392 1.5425401
84R:R:Y408 6.18286723
85R:R:Y411 7.525425
86R:R:L414 4.865426
87R:R:R415 7.1225405
88R:R:S417 3.6975426
89R:R:Y418 6.736527
90R:R:Y421 7.9075428
91R:R:W458 9.3425484
92R:R:Q459 8.4875487
93R:R:L461 4.37487
94R:R:F469 9.2854378
95R:R:N471 3.38833626
96R:R:M473 4.036524
97R:R:D484 7.68254108
98R:R:W494 6.688537
99R:R:S497 3.4685383
100R:R:F505 4.792534
101R:R:Y511 6.238505
102R:R:Y514 4.39404
103R:R:W530 6.667138
104R:R:T550 3.1854396
105R:R:R551 7.8875407
106R:R:K552 7.87408
107R:R:C582 4.56754409
108R:R:I603 3.7754164
109R:R:W608 4.5825405
110R:R:L616 3.7875408
111R:R:G623 4.24254206
112R:R:L626 2.33754204
113R:R:V630 3.854187
114R:R:F634 3.6025189
115R:R:F637 3.474184
116R:R:R648 4.205408
117R:R:L655 4.24754189
118R:R:F662 7.075208
119R:R:F668 8.2275409
120R:R:P672 4.294169
121R:R:W675 5.4125403
122R:R:Q681 9.0025409
123R:R:F684 6.748336238
124R:R:F688 5.435408
125R:R:V689 3.8165427
126R:R:I692 4.52754247
127R:R:L696 4.234248
128R:R:F706 6.4154199
129R:R:W719 3.6565436
130R:R:Q724 6.715408
131R:R:P748 2.63409
132R:R:I760 5.5645175
133R:R:I761 7.614167
134R:R:F762 6.366676177
135R:R:I777 3.908508
136R:R:Y779 7.05754429
137R:R:F788 3.466578
138R:R:F790 3.09754247
139R:R:L797 3.58254198
140R:R:F801 5.97754199
141R:R:T808 3.59479
142R:R:F809 4.3325479
143R:R:F814 5.815239
144R:R:I816 3.7408
145R:R:F821 4.03609
146R:R:P823 3.30254269
147R:R:L842 2.83254209
148R:R:F853 5.868336189
149R:R:I860 3.755409
150S:S:F38 5.072517
151S:S:H41 7.1517
152S:S:F42 8.07754443
153S:S:V44 3.645412
154S:S:L51 2.67486
155S:S:P55 5.7486
156S:S:C60 5.635417
157S:S:Y63 5.73715
158S:S:F65 5.998512
159S:S:R66 8.305415
160S:S:F68 7.3175417
161S:S:R69 7.8675418
162S:S:W70 7.06333615
163S:S:L71 4.57514
164S:S:Q72 4.67617
165S:S:M74 3.5625408
166S:S:I75 4.615414
167S:S:F76 6.3725417
168S:S:L87 4.442516
169S:S:Y95 6.92408
170S:S:I97 4.505418
171S:S:F98 6.882504
172S:S:C101 5.504518
173S:S:F114 4.55505
174S:S:I135 4.196676324
175S:S:T145 4.276515
176S:S:S147 2.8825418
177S:S:V153 4.1525466
178S:S:L157 3.416567
179S:S:F160 5.67667667
180S:S:I162 3.5225466
181S:S:P163 3.43667608
182S:S:Q164 5.128568
183S:S:Y167 5.114518
184S:S:S169 4.54408
185S:S:L173 4.5265345
186S:S:L174 8.105467
187S:S:F180 7.274565
188S:S:F183 7.128568
189S:S:R185 6.626569
190S:S:Q193 4.978509
191S:S:M197 4.87254467
192S:S:F204 8.4775497
193S:S:W208 6.32875859
194S:S:T211 3.7075405
195S:S:Y218 4.155617
196S:S:K225 6.20254453
197S:S:F226 2.8585466
198S:S:E229 6.5554455
199S:S:R233 6.766504
200S:S:F239 4.91333656
201S:S:V266 5.78407
202S:S:I267 4.44457
203S:S:V269 4.308555
204S:S:F270 4.1775407
205S:S:P274 3.395443
206S:S:D275 3.1954475
207S:S:L276 5.86555
208S:S:I280 4.2075455
209S:S:E282 5.6925256
210S:S:R286 6.2685254
211S:S:I292 3.305497
212S:S:W293 5.3475458
213S:S:L294 3.2875407
214S:S:S296 3.6025408
215S:S:W299 5.70143757
216S:S:L304 3.84254442
217S:S:I305 3.8725454
218S:S:Y310 6.42403
219S:S:F311 6.9975403
220S:S:F320 4.738506
221S:S:G325 4.305414
222S:S:I327 4.86333616
223S:S:F330 5.61518
224S:S:L334 5.73167616
225S:S:V337 2.745415
226S:S:N345 3.268518
227S:S:F347 4.878515
228S:S:F351 8.02333616
229S:S:W352 11.434518
230S:S:T355 6.6275414
231S:S:F356 11.54418
232S:S:L360 5.1404
233S:S:E399 7.425418
234S:S:Y408 7.155613
235S:S:Y411 8.74415
236S:S:L414 4.6575416
237S:S:Y418 6.99417
238S:S:Y421 8.986518
239S:S:F444 3.131676123
240S:S:W458 7.1465124
241S:S:Q459 6.7465127
242S:S:L461 5.024317
243S:S:K462 5.405404
244S:S:F469 9.285418
245S:S:N471 4.17833616
246S:S:N472 4.75414
247S:S:M473 4.99667614
248S:S:D484 7.1525468
249S:S:I491 2.57408
250S:S:N493 5.7675499
251S:S:W494 7.13833657
252S:S:H495 6.7825407
253S:S:I503 3.85454
254S:S:Y511 5.09833605
255S:S:Y514 4.8754504
256S:S:L521 4.97495
257S:S:I523 4.41496
258S:S:W530 6.33143798
259S:S:R551 7.2125407
260S:S:K552 7.9545148
261S:S:C582 4.64519
262S:S:W590 6.015406
263S:S:T596 1.97405
264S:S:C598 5.8254279
265S:S:E604 5.6375406
266S:S:W608 6.0175405
267S:S:E610 4.615407
268S:S:T627 4.3325407
269S:S:V630 4.5365157
270S:S:F634 3.8525159
271S:S:T640 4.065409
272S:S:I642 4.62254117
273S:S:L654 3.4254158
274S:S:L655 4.215159
275S:S:F662 5.995538
276S:S:F668 5.668509
277S:S:P672 4.565449
278S:S:R680 5.046548
279S:S:Q681 5.354549
280S:S:F684 6.70857748
281S:S:F688 5.046508
282S:S:R701 3.59508
283S:S:Q735 6.9225449
284S:S:W742 5.32549
285S:S:I763 4.265447
286S:S:L773 4.22448
287S:S:I777 3.9225448
288S:S:F790 4.2407
289S:S:F801 4.325119
290S:S:F809 6.478579
291S:S:M811 3.9575409
292S:S:F814 8.065409
293S:S:W818 8.862549
294S:S:F821 5.272549
295S:S:Y825 8.758549
296S:S:F832 4.7545265
297S:S:E837 5.595449
298S:S:V838 4.3675407
299S:S:F853 6.074297159
300S:S:I859 5.04754119
301S:S:K863 14.73754117
302S:S:N867 8.0754119
303S:S:T868 8.0354116
304S:S:R873 6.85254115
305W:W:?1 9.13710230
306W:W:?2 4.321870
307W:W:W5 4.428520
308W:W:?6 9.68620
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1K:K:?1 K:K:?2 28.52856.71YesYes400
2K:K:?2 R:R:F832 82.10494.86YesNo005
3K:K:?2 S:S:P823 48.80749.82YesNo409
4R:R:F832 R:R:K831 82.20796.2NoNo059
5R:R:E604 R:R:K831 86.28998.1NoNo069
6R:R:E604 R:R:I760 86.20184.1NoYes1765
7R:R:E759 R:R:I760 87.8555.47NoYes1745
8R:R:E759 R:R:W590 89.55055.45NoNo046
9R:R:G571 R:R:W590 89.75098.44NoNo076
10R:R:G571 R:R:S591 89.8513.71NoNo078
11R:R:H595 R:R:S591 89.9515.58NoNo058
12R:R:C568 R:R:H595 90.15092.95NoNo095
13R:R:C568 R:R:C582 90.557.28NoYes099
14R:R:C582 R:R:R551 90.94814.18YesYes097
15R:R:G553 R:R:R551 95.06891.5NoYes067
16R:R:G553 R:R:K552 95.16561.74NoYes068
17R:R:K552 S:S:I554 96.13021.45YesNo083
18R:R:S580 S:S:I554 97.27963.1NoNo043
19R:R:S580 S:S:E556 97.3757.19NoNo046
20S:S:E556 S:S:I555 97.47031.37NoNo065
21S:S:E558 S:S:I555 97.56555.47NoNo055
22S:S:E558 S:S:P559 97.66074.72NoNo056
23S:S:P559 S:S:W208 97.75592.7NoYes069
24S:S:D238 S:S:W208 99.175514.52NoYes589
25S:S:D238 S:S:F239 99.24423.58NoYes586
26S:S:F239 S:S:I267 96.89462.51YesYes567
27S:S:I212 S:S:I267 32.68862.94NoYes067
28S:S:I212 S:S:V269 32.99613.07NoYes065
29S:S:V269 S:S:W299 64.24799.81YesYes557
30S:S:S296 S:S:W299 98.36182.47YesYes087
31S:S:S296 S:S:Y218 1005.09YesYes087
32S:S:S147 S:S:Y218 80.6212.54YesYes187
33S:S:S147 S:S:S169 88.58693.26YesYes088
34S:S:S150 S:S:S169 86.53326.52NoYes088
35S:S:Q164 S:S:S150 86.26082.89YesNo088
36S:S:L157 S:S:Q164 84.60315.32YesYes678
37S:S:I162 S:S:L157 83.13542.85YesYes667
38S:S:F160 S:S:I162 77.01785.02YesYes676
39S:S:F160 S:S:K119 77.22752.48YesNo073
40R:R:K119 S:S:K119 77.31115.8NoNo033
41R:R:F160 R:R:K119 76.52722.48YesNo073
42R:R:F160 R:R:I162 76.05882.51YesNo076
43R:R:I162 R:R:L157 73.36484.28NoYes067
44R:R:L157 R:R:Q164 70.74026.65YesYes1078
45R:R:Q164 R:R:S150 46.01162.89YesNo088
46R:R:S150 R:R:S169 45.73466.52NoYes088
47R:R:S147 R:R:S169 45.69123.26NoYes088
48R:R:S147 R:R:Y218 44.75592.54NoYes087
49R:R:S296 R:R:Y218 18.83285.09NoYes087
50R:R:S296 R:R:W299 12.78262.47NoYes087
51S:S:I267 S:S:W293 64.28789.4YesYes578
52S:S:V269 S:S:W293 32.23822.45YesYes558
53S:S:T317 S:S:W293 32.2776.06NoYes078
54S:S:T317 S:S:W299 32.44152.43NoYes077
55K:K:W5 S:S:Y218 21.01723.86YesYes107
56K:K:W5 S:S:T145 27.58174.85YesYes105
57S:S:T145 S:S:W70 21.0372.43YesYes155
58R:R:Y218 W:W:W5 23.38213.86YesYes270
59R:R:F38 R:R:Y167 10.15779.28YesYes278
60R:R:R66 W:W:W5 10.66583YesYes250
61R:R:R66 R:R:R69 10.25435.33YesYes258
62R:R:L334 R:R:R69 13.56433.64YesYes268
63R:R:F183 R:R:Q164 25.15287.03YesYes1088
64R:R:F183 R:R:R185 23.64587.48YesYes1089
65R:R:I187 R:R:R185 20.28413.76YesYes069
66R:R:I187 R:R:L322 12.12962.85YesNo064
67R:R:L322 R:R:R415 11.59862.43NoYes045
68R:R:R415 W:W:?6 10.90176.99YesYes050
69R:R:F821 S:S:P823 48.69982.89YesNo099
70R:R:A840 R:R:F821 16.29962.77NoYes099
71R:R:A840 R:R:W818 16.17559.08NoNo099
72R:R:W818 W:W:?1 12.450824.1NoYes2390
73R:R:F821 R:R:V817 15.98512.62YesNo099
74R:R:V817 S:S:S820 15.85324.85NoNo097
75R:R:I816 S:S:S820 31.43883.1YesNo087
76R:R:I816 W:W:?2 29.9355.69YesYes080
77R:R:K805 W:W:?2 16.40046.56NoYes790
78R:R:F806 R:R:K805 16.45916.2NoNo059
79R:R:E803 R:R:F806 15.9234.66NoNo095
80R:R:E803 R:R:I852 14.85195.47NoNo099
81R:R:F853 R:R:I852 14.617711.3YesNo099
82R:R:F821 R:R:S820 15.98522.64YesNo097
83R:R:S820 S:S:S820 15.85314.89NoNo077
84R:R:F634 R:R:F853 10.85875.36YesYes1899
85K:K:?1 S:S:F684 16.356711.55YesYes408
86S:S:L334 S:S:R69 11.39723.64YesYes168
87S:S:C661 S:S:F684 13.26092.79NoYes078
88S:S:C661 S:S:S845 12.71285.16NoNo078
89S:S:F662 S:S:S845 12.5779.25YesNo088
90S:S:F662 S:S:T627 12.35392.59YesYes087
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
K:K:?1 K:K:?2 6.71 4 Yes Yes 0 0 1 0
K:K:?1 S:S:Q681 11.66 4 Yes Yes 0 9 1 2
K:K:?1 S:S:F684 11.55 4 Yes Yes 0 8 1 2
K:K:?1 S:S:G685 2.5 4 Yes No 0 8 1 2
K:K:?1 S:S:E767 7.74 4 Yes No 0 7 1 2
K:K:?1 S:S:L770 4.04 4 Yes No 0 3 1 2
K:K:?1 S:S:L773 6.06 4 Yes Yes 0 8 1 2
K:K:?1 S:S:I777 7.29 4 Yes Yes 0 8 1 1
K:K:?1 S:S:T780 6.45 4 Yes No 0 7 1 2
K:K:?1 S:S:W818 12.47 4 Yes Yes 0 9 1 2
K:K:?1 S:S:F821 2.67 4 Yes Yes 0 9 1 2
K:K:?1 S:S:Y825 10.27 4 Yes Yes 0 9 1 1
K:K:?1 S:S:E837 5.8 4 Yes Yes 0 9 1 2
K:K:?2 R:R:F612 3.24 4 Yes No 0 8 0 1
K:K:?2 R:R:F832 4.86 4 Yes No 0 5 0 1
K:K:?2 S:S:I777 3.79 4 Yes Yes 0 8 0 1
K:K:?2 S:S:I819 5.69 4 Yes No 0 6 0 1
K:K:?2 S:S:I822 6.64 4 Yes No 0 7 0 1
K:K:?2 S:S:P823 9.82 4 Yes No 0 9 0 1
K:K:?2 S:S:Y825 12.46 4 Yes Yes 0 9 0 1
K:K:?2 S:S:A826 5.23 4 Yes No 0 5 0 1
K:K:?2 S:S:Y829 14.02 4 Yes No 0 6 0 1
R:R:A835 R:R:F612 2.77 0 No No 8 8 2 1
R:R:F821 S:S:P823 2.89 0 Yes No 9 9 2 1
R:R:T828 S:S:Y829 2.5 0 No No 8 6 2 1
R:R:F832 R:R:K831 6.2 0 No No 5 9 1 2
S:S:L773 S:S:Q681 3.99 4 Yes Yes 8 9 2 2
S:S:F684 S:S:G685 3.01 4 Yes No 8 8 2 2
S:S:F684 S:S:W818 3.01 4 Yes Yes 8 9 2 2
S:S:E767 S:S:L773 3.98 4 No Yes 7 8 2 2
S:S:I777 S:S:L773 2.85 4 Yes Yes 8 8 1 2
S:S:F821 S:S:W818 9.02 4 Yes Yes 9 9 2 2
S:S:F821 S:S:Y825 9.28 4 Yes Yes 9 9 2 1
S:S:I822 S:S:P823 5.08 4 No No 7 9 1 1
S:S:V833 S:S:Y825 5.05 4 No Yes 6 9 2 1
S:S:E837 S:S:Y825 6.73 4 Yes Yes 9 9 2 1
S:S:E837 S:S:V833 2.85 4 Yes No 9 6 2 2
K:K:?2 S:S:C781 2.11 4 Yes No 0 7 0 1
S:S:G774 S:S:I777 1.76 0 No Yes 4 8 2 1
K:K:?2 R:R:A843 1.05 4 Yes No 0 7 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
K:K:?1 K:K:?2 6.71 4 Yes Yes 0 0 0 1
K:K:?1 S:S:Q681 11.66 4 Yes Yes 0 9 0 1
K:K:?1 S:S:F684 11.55 4 Yes Yes 0 8 0 1
K:K:?1 S:S:G685 2.5 4 Yes No 0 8 0 1
K:K:?1 S:S:E767 7.74 4 Yes No 0 7 0 1
K:K:?1 S:S:L770 4.04 4 Yes No 0 3 0 1
K:K:?1 S:S:L773 6.06 4 Yes Yes 0 8 0 1
K:K:?1 S:S:I777 7.29 4 Yes Yes 0 8 0 1
K:K:?1 S:S:T780 6.45 4 Yes No 0 7 0 1
K:K:?1 S:S:W818 12.47 4 Yes Yes 0 9 0 1
K:K:?1 S:S:F821 2.67 4 Yes Yes 0 9 0 1
K:K:?1 S:S:Y825 10.27 4 Yes Yes 0 9 0 1
K:K:?1 S:S:E837 5.8 4 Yes Yes 0 9 0 1
K:K:?2 R:R:F612 3.24 4 Yes No 0 8 1 2
K:K:?2 R:R:F832 4.86 4 Yes No 0 5 1 2
K:K:?2 S:S:I777 3.79 4 Yes Yes 0 8 1 1
K:K:?2 S:S:I819 5.69 4 Yes No 0 6 1 2
K:K:?2 S:S:I822 6.64 4 Yes No 0 7 1 2
K:K:?2 S:S:P823 9.82 4 Yes No 0 9 1 2
K:K:?2 S:S:Y825 12.46 4 Yes Yes 0 9 1 1
K:K:?2 S:S:A826 5.23 4 Yes No 0 5 1 2
K:K:?2 S:S:Y829 14.02 4 Yes No 0 6 1 2
S:S:C661 S:S:F684 2.79 0 No Yes 7 8 2 1
S:S:F684 S:S:S664 5.28 4 Yes No 8 6 1 2
S:S:F668 S:S:R680 9.62 0 Yes Yes 9 8 2 2
S:S:E837 S:S:F668 7 4 Yes Yes 9 9 1 2
S:S:F668 S:S:I841 2.51 0 Yes No 9 9 2 2
S:S:Q681 S:S:R680 4.67 4 Yes Yes 9 8 1 2
S:S:P682 S:S:Q681 3.16 4 No Yes 5 9 2 1
S:S:Q681 S:S:W742 3.29 4 Yes Yes 9 9 1 2
S:S:L773 S:S:Q681 3.99 4 Yes Yes 8 9 1 1
S:S:P682 S:S:W742 4.05 4 No Yes 5 9 2 2
S:S:F684 S:S:G685 3.01 4 Yes No 8 8 1 1
S:S:F684 S:S:F688 7.5 4 Yes Yes 8 8 1 2
S:S:F684 S:S:W818 3.01 4 Yes Yes 8 9 1 1
S:S:F684 S:S:I841 13.82 4 Yes No 8 9 1 2
S:S:F688 S:S:F814 7.5 0 Yes Yes 8 9 2 2
S:S:Q735 S:S:V689 10.03 4 Yes No 9 7 2 2
S:S:T780 S:S:V689 4.76 4 No No 7 7 1 2
S:S:Q735 S:S:T780 4.25 4 Yes No 9 7 2 1
S:S:E767 S:S:L773 3.98 4 No Yes 7 8 1 1
S:S:I777 S:S:L773 2.85 4 Yes Yes 8 8 1 1
S:S:F814 S:S:W818 12.03 0 Yes Yes 9 9 2 1
S:S:F821 S:S:W818 9.02 4 Yes Yes 9 9 1 1
S:S:A840 S:S:W818 7.78 4 No Yes 9 9 2 1
S:S:F821 S:S:Y825 9.28 4 Yes Yes 9 9 1 1
S:S:F821 S:S:V836 2.62 4 Yes No 9 8 1 2
S:S:A840 S:S:F821 2.77 4 No Yes 9 9 2 1
S:S:I822 S:S:P823 5.08 4 No No 7 9 2 2
S:S:V833 S:S:Y825 5.05 4 No Yes 6 9 2 1
S:S:E837 S:S:Y825 6.73 4 Yes Yes 9 9 1 1
S:S:E837 S:S:V833 2.85 4 Yes No 9 6 1 2
K:K:?2 S:S:C781 2.11 4 Yes No 0 7 1 2
S:S:G774 S:S:I777 1.76 0 No Yes 4 8 2 1
K:K:?2 R:R:A843 1.05 4 Yes No 0 7 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
K:K:W5 S:S:T145 4.85 1 Yes Yes 0 5 0 1
K:K:W5 S:S:S147 2.47 1 Yes Yes 0 8 0 1
K:K:W5 S:S:Y218 3.86 1 Yes Yes 0 7 0 1
K:K:W5 S:S:S272 2.47 1 Yes No 0 5 0 1
K:K:W5 S:S:E297 4.36 1 Yes No 0 8 0 1
K:K:W5 S:S:A298 2.59 1 Yes No 0 6 0 1
S:S:P39 S:S:T145 6.99 0 No Yes 6 5 2 1
S:S:T145 S:S:W70 2.43 1 Yes Yes 5 5 1 2
S:S:T145 S:S:Y167 3.75 1 Yes Yes 5 8 1 2
S:S:A168 S:S:T145 3.36 1 No Yes 5 5 2 1
S:S:S147 S:S:S169 3.26 1 Yes Yes 8 8 1 2
S:S:S147 S:S:S171 3.26 1 Yes No 8 7 1 2
S:S:S147 S:S:Y218 2.54 1 Yes Yes 8 7 1 1
S:S:A168 S:S:Y167 2.67 1 No Yes 5 8 2 2
S:S:D190 S:S:S170 8.83 1 No No 8 7 2 2
S:S:S170 S:S:Y218 2.54 1 No Yes 7 7 2 1
S:S:E297 S:S:I187 2.73 0 No No 8 6 1 2
S:S:D190 S:S:Q193 5.22 1 No Yes 8 9 2 2
S:S:D190 S:S:Y218 6.9 1 No Yes 8 7 2 1
S:S:Q193 S:S:S296 2.89 0 Yes Yes 9 8 2 2
S:S:E297 S:S:Q193 6.37 0 No Yes 8 9 1 2
S:S:S296 S:S:Y218 5.09 0 Yes Yes 8 7 2 1
S:S:A298 S:S:Y218 4 1 No Yes 6 7 1 1
S:S:P274 S:S:S272 3.56 44 Yes No 3 5 2 1
S:S:D275 S:S:S272 4.42 47 Yes No 5 5 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F788 R:R:T808 3.89 7 Yes Yes 8 9 1 1
R:R:F788 R:R:M811 3.73 7 Yes No 8 9 1 2
R:R:F788 R:R:L812 2.44 7 Yes No 8 9 1 1
R:R:F788 R:R:F815 3.22 7 Yes No 8 7 1 2
R:R:F788 W:W:?2 4.05 7 Yes Yes 8 0 1 0
R:R:F792 R:R:R795 11.76 7 No No 8 9 1 1
R:R:F792 W:W:?2 4.86 7 No Yes 8 0 1 0
R:R:K796 R:R:R795 2.48 0 No No 7 9 2 1
R:R:R795 W:W:?2 3.23 7 No Yes 9 0 1 0
R:R:A804 W:W:?2 3.14 0 No Yes 9 0 1 0
R:R:F806 R:R:K805 6.2 0 No No 5 9 2 1
R:R:K805 S:S:F809 3.72 7 No Yes 9 9 1 1
R:R:K805 W:W:?2 6.56 7 No Yes 9 0 1 0
R:R:F809 R:R:T808 3.89 7 Yes Yes 9 9 1 1
R:R:T808 W:W:?2 4.9 7 Yes Yes 9 0 1 0
R:R:F809 S:S:F809 8.57 7 Yes Yes 9 9 1 1
R:R:F809 S:S:L812 2.44 7 Yes No 9 9 1 2
R:R:F809 W:W:?2 2.43 7 Yes Yes 9 0 1 0
R:R:L812 W:W:?2 2.76 7 No Yes 9 0 1 0
R:R:I816 S:S:I816 2.94 0 Yes No 8 8 1 2
R:R:I816 S:S:V817 3.07 0 Yes No 8 9 1 2
R:R:I816 S:S:S820 3.1 0 Yes No 8 7 1 2
R:R:I816 W:W:?2 5.69 0 Yes Yes 8 0 1 0
R:R:I819 W:W:?2 9.48 0 No Yes 6 0 1 0
S:S:K805 S:S:N802 4.2 7 No No 9 9 1 2
S:S:F809 S:S:K805 7.44 7 Yes No 9 9 1 1
S:S:K805 W:W:?2 3.75 7 No Yes 9 0 1 0
S:S:F809 W:W:?2 10.52 7 Yes Yes 9 0 1 0
S:S:A843 S:S:V817 3.39 0 No No 7 9 1 2
S:S:A843 W:W:?2 3.14 0 No Yes 7 0 1 0
S:S:G847 W:W:?2 3.41 0 No Yes 8 0 1 0
S:S:C851 W:W:?2 4.22 0 No Yes 8 0 1 0
R:R:F789 R:R:F792 2.14 0 No No 4 8 2 1
S:S:F806 S:S:F809 2.14 0 No Yes 5 9 2 1
S:S:I813 W:W:?2 1.9 0 No Yes 8 0 1 0
S:S:I839 W:W:?2 1.9 0 No Yes 7 0 1 0
R:R:N802 W:W:?2 1.82 0 No Yes 9 0 1 0
R:R:A791 R:R:T808 1.68 0 No Yes 9 9 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C661 R:R:F684 2.79 0 No Yes 7 8 2 1
R:R:F684 R:R:S664 3.96 23 Yes No 8 6 1 2
R:R:E837 R:R:F668 10.49 0 No Yes 9 9 1 2
R:R:F668 R:R:I841 3.77 0 Yes No 9 9 2 2
R:R:Q681 R:R:W742 4.38 0 Yes No 9 9 1 2
R:R:E767 R:R:Q681 10.19 0 No Yes 7 9 2 1
R:R:L773 R:R:Q681 14.64 0 No Yes 8 9 2 1
R:R:Q681 W:W:?1 6.8 0 Yes Yes 9 0 1 0
R:R:F684 R:R:G685 3.01 23 Yes No 8 8 1 1
R:R:F684 R:R:F688 3.22 23 Yes Yes 8 8 1 2
R:R:F684 R:R:I841 15.07 23 Yes No 8 9 1 2
R:R:F684 W:W:?1 12.44 23 Yes Yes 8 0 1 0
R:R:G685 W:W:?1 2.5 23 No Yes 8 0 1 0
R:R:F688 R:R:T780 2.59 0 Yes No 8 7 2 1
R:R:F688 R:R:F814 9.65 0 Yes Yes 8 9 2 1
R:R:T780 R:R:V689 3.17 0 No Yes 7 7 1 2
R:R:I777 R:R:L773 4.28 0 Yes No 8 8 1 2
R:R:G774 R:R:I777 3.53 0 No Yes 4 8 2 1
R:R:I777 W:W:?1 8.33 0 Yes Yes 8 0 1 0
R:R:T780 W:W:?1 6.45 0 No Yes 7 0 1 0
R:R:F814 R:R:F815 6.43 23 Yes No 9 7 1 2
R:R:F814 R:R:W818 8.02 23 Yes No 9 9 1 1
R:R:F814 W:W:?1 3.56 23 Yes Yes 9 0 1 0
R:R:A840 R:R:W818 9.08 0 No No 9 9 2 1
R:R:W818 W:W:?1 24.1 23 No Yes 9 0 1 0
R:R:I822 R:R:P823 3.39 0 No Yes 7 9 1 2
R:R:I822 W:W:?1 4.17 0 No Yes 7 0 1 0
R:R:V833 R:R:Y825 2.52 0 No No 6 9 2 1
R:R:Y825 W:W:?1 16.25 0 No Yes 9 0 1 0
R:R:E837 W:W:?1 6.77 0 No Yes 9 0 1 0
R:R:G778 R:R:I777 1.76 0 No Yes 5 8 2 1
R:R:C781 R:R:I777 1.64 0 No Yes 7 8 2 1
R:R:A844 R:R:F814 1.39 0 No Yes 9 9 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P39 R:R:T145 5.25 0 No Yes 6 5 2 1
R:R:R66 R:R:R69 5.33 2 Yes Yes 5 8 1 2
R:R:R66 R:R:W70 12 2 Yes Yes 5 5 1 2
R:R:R66 W:W:W5 3 2 Yes Yes 5 0 1 0
R:R:R66 W:W:?6 16.77 2 Yes Yes 5 0 1 2
R:R:R69 W:W:?6 9.78 2 Yes Yes 8 0 2 2
R:R:T145 R:R:W70 3.64 2 Yes Yes 5 5 1 2
R:R:W70 R:R:Y167 2.89 2 Yes Yes 5 8 2 2
R:R:W70 W:W:?6 7.86 2 Yes Yes 5 0 2 2
R:R:T145 R:R:Y167 4.99 2 Yes Yes 5 8 1 2
R:R:A168 R:R:T145 3.36 2 No Yes 5 5 1 1
R:R:T145 W:W:W5 4.85 2 Yes Yes 5 0 1 0
R:R:S147 R:R:Y218 2.54 0 No Yes 8 7 2 1
R:R:A168 R:R:Y167 2.67 2 No Yes 5 8 1 2
R:R:A168 W:W:W5 3.89 2 No Yes 5 0 1 0
R:R:D190 R:R:S170 8.83 2 No No 8 7 2 2
R:R:S170 R:R:Y218 2.54 2 No Yes 7 7 2 1
R:R:D190 R:R:Q193 7.83 2 No No 8 9 2 2
R:R:D190 R:R:Y218 5.75 2 No Yes 8 7 2 1
R:R:E297 R:R:Q193 7.65 0 No No 8 9 1 2
R:R:D216 R:R:Y218 3.45 2 Yes Yes 6 7 2 1
R:R:S296 R:R:Y218 5.09 0 No Yes 8 7 2 1
R:R:A298 R:R:Y218 4 0 No Yes 6 7 2 1
R:R:Y218 W:W:W5 3.86 2 Yes Yes 7 0 1 0
R:R:E297 R:R:L322 2.65 0 No No 8 4 1 2
R:R:E297 W:W:W5 6.54 0 No Yes 8 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8SZH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.43
Number of Linked Nodes 1570
Number of Links 1932
Number of Hubs 308
Number of Links mediated by Hubs 1147
Number of Communities 53
Number of Nodes involved in Communities 473
Number of Links involved in Communities 683
Path Summary
Number Of Nodes in MetaPath 91
Number Of Links MetaPath 90
Number of Shortest Paths 4611927
Length Of Smallest Path 3
Average Path Length 44.0979
Length of Longest Path 81
Minimum Path Strength 1.16
Average Path Strength 5.07701
Maximum Path Strength 21.005
Minimum Path Correlation 0.7
Average Path Correlation 0.99755
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.96078
Average % Of Corr. Nodes 63.1445
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.7125
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • amino acid binding   • identical protein binding   • protein binding   • cation binding   • ion binding   • calcium ion binding   • metal ion binding   • small molecule binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • phosphoric ester hydrolase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • phospholipase C activity   • hydrolase activity   • phosphatidylinositol-4,5-bisphosphate phospholipase C activity   • catalytic activity   • phospholipase activity   • lipase activity   • transmembrane transporter binding   • cell adhesion molecule binding   • protein-containing complex binding   • integrin binding   • signaling receptor binding   • protein homodimerization activity   • protein dimerization activity   • kinase binding   • enzyme binding   • protein kinase binding   • biological regulation   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • regulation of biological process   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization
Gene OntologyBiological Process• biological regulation   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • regulation of biological process   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • developmental process   • multicellular organismal process   • epithelium development   • tube development   • branching morphogenesis of an epithelial tube   • morphogenesis of an epithelium   • tissue development   • tissue morphogenesis   • anatomical structure morphogenesis   • multicellular organism development   • tube morphogenesis   • morphogenesis of a branching structure   • anatomical structure development   • epithelial tube morphogenesis   • morphogenesis of a branching epithelium   • regulation of tube diameter   • system process   • regulation of tube size   • regulation of system process   • positive regulation of biological process   • positive regulation of vasoconstriction   • circulatory system process   • regulation of blood circulation   • vascular process in circulatory system   • regulation of vasoconstriction   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • blood vessel diameter maintenance   • vasoconstriction   • blood circulation   • regulation of anatomical structure size   • monoatomic ion transmembrane transport   • inorganic ion transmembrane transport   • inorganic anion transmembrane transport   • chloride transport   • transmembrane transport   • chloride transmembrane transport   • monoatomic anion transport   • monoatomic anion transmembrane transport   • cellular process   • inorganic anion transport   • regulation of biosynthetic process   • regulation of cellular process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • response to stimulus   • response to stress   • response to ischemia   • response to decreased oxygen levels   • cellular response to stimulus   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to chemical stimulus   • cellular response to stress   • response to hypoxia   • response to chemical   • response to oxygen levels   • response to abiotic stimulus   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • organic acid transport   • bile acid secretion   • organic anion transport   • monocarboxylic acid transport   • carboxylic acid transport   • secretion   • acid secretion   • response to peptide   • cellular response to peptide   • behavior   • chemosensory behavior   • signaling   • intracellular signal transduction   • cell communication   • JNK cascade   • intracellular signaling cassette   • MAPK cascade   • signal transduction   • cellular response to low-density lipoprotein particle stimulus   • response to endogenous stimulus   • response to lipoprotein particle   • response to nitrogen compound   • cellular response to lipoprotein particle stimulus   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • regulation of calcium ion import   • positive regulation of calcium ion transport   • positive regulation of calcium ion import   • positive regulation of transport   • positive regulation of monoatomic ion transport   • calcium ion import   • ossification   • connective tissue development   • adipose tissue development   • fat pad development   • animal organ development   • response to fibroblast growth factor   • response to growth factor   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • response to oxygen-containing compound   • cellular response to glucose stimulus   • intracellular glucose homeostasis   • cellular response to oxygen-containing compound   • response to hexose   • cellular response to carbohydrate stimulus   • response to monosaccharide   • response to carbohydrate   • response to glucose   • glucose homeostasis   • carbohydrate homeostasis   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • response to nutrient levels   • response to lipid   • response to nutrient   • response to vitamin   • cellular response to vitamin D   • cellular response to nutrient levels   • response to vitamin D   • cellular response to vitamin   • cellular response to lipid   • cellular response to nutrient   • cell population proliferation   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • vasodilation   • positive chemotaxis   • chemotaxis   • positive regulation of locomotion   • regulation of response to external stimulus   • positive regulation of positive chemotaxis   • response to external stimulus   • regulation of chemotaxis   • positive regulation of chemotaxis   • regulation of positive chemotaxis   • positive regulation of response to external stimulus   • taxis   • regulation of locomotion   • locomotion   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular response to endogenous stimulus   • response to hepatocyte growth factor   • cellular response to growth factor stimulus   • cellular response to hepatocyte growth factor stimulus   • protein localization   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • cellular macromolecule localization   • positive regulation of insulin secretion   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • regulation of protein secretion   • regulation of secretion   • positive regulation of protein localization   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • positive regulation of secretion   • amide transport   • signal release   • positive regulation of peptide secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • detection of stimulus   • response to metal ion   • detection of chemical stimulus   • detection of calcium ion   • response to calcium ion   • cell periphery   • presynapse   • cellular anatomical structure   • synapse   • cell junction   • membrane   • plasma membrane   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse
Gene OntologyCellular Component• cell periphery   • presynapse   • cellular anatomical structure   • synapse   • cell junction   • membrane   • plasma membrane   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse   • somatodendritic compartment   • cell body   • neuronal cell body   • apical part of cell   • apical plasma membrane   • cell surface   • axon   • neuron projection   • axon terminus   • plasma membrane bounded cell projection   • cell projection   • distal axon   • neuron projection terminus   • binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • GDP binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • cation binding   • metal ion binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular process   • cell division   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • regulation of molecular function   • negative regulation of lyase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • positive regulation of autophagy   • catabolic process   • macroautophagy   • autophagy   • positive regulation of biological process   • regulation of catabolic process   • regulation of autophagy   • positive regulation of catabolic process   • positive regulation of metabolic process   • regulation of macroautophagy   • metabolic process   • positive regulation of macroautophagy   • process utilizing autophagic mechanism   • regulation of metabolic process   • positive regulation of cellular process   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • nucleoside phosphate metabolic process   • ribose phosphate metabolic process   • purine nucleoside triphosphate metabolic process   • GTP metabolic process   • carbohydrate derivative metabolic process   • primary metabolic process   • nucleotide metabolic process   • purine-containing compound metabolic process   • nucleobase-containing compound metabolic process   • purine nucleotide metabolic process   • ribonucleotide metabolic process   • organophosphate metabolic process   • nucleobase-containing small molecule metabolic process   • purine ribonucleoside triphosphate metabolic process   • phosphate-containing compound metabolic process   • small molecule metabolic process   • nucleoside triphosphate metabolic process   • purine ribonucleotide metabolic process   • phosphorus metabolic process   • ribonucleoside triphosphate metabolic process   • midbody   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytoplasm   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • ciliary basal body   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Type 1 solute binding protein-like   • TNF receptor-like   • Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Type 1 solute binding protein-like   • TNF receptor-like   • Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeYP4
PDB ResiduesK:K:?1 W:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeYP4
NameCinacalcet
Synonyms
  • Cinacalcet hydrochloride
  • (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine
  • N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine
  • Cinacalcet
  • CNC
Identifier
FormulaC22 H22 F3 N
Molecular Weight357.412
SMILES
PubChem156419
Formal Charge0
Total Atoms48
Total Chiral Atoms1
Total Bonds50
Total Aromatic Bonds17

CodePCW
PDB ResiduesK:K:?2 W:W:?2
Environment DetailsOpen EMBL-EBI Page
CodePCW
Name(Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide
Synonyms(Z,Z)-4-HYDROXY-N,N,N-TRIMETHYL-10-OXO-7-[(1-OXO-9-OCTADECENYL)OXY]-3,5,9-TRIOXA-4-PHOSPHAHEPTACOS-18-EN-1-AMINIUM-4-OXIDE
Identifier
FormulaC44 H85 N O8 P
Molecular Weight787.121
SMILES
PubChem448653
Formal Charge1
Total Atoms139
Total Chiral Atoms2
Total Bonds138
Total Aromatic Bonds0

CodeCA
PDB ResiduesK:K:?3 K:K:?4 W:W:?3 W:W:?4
Environment DetailsOpen EMBL-EBI Page
CodeCA
NameCALCIUM ION
Synonyms
Identifier
FormulaCa
Molecular Weight40.078
SMILES
PubChem
Formal Charge2
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

CodePO4
PDB ResiduesK:K:?6 W:W:?6
Environment DetailsOpen EMBL-EBI Page
CodePO4
NamePhosphate ion
Synonyms
  • Phosphate
  • Phosphate ion
  • Orthophosphate
Identifier
FormulaO4 P
Molecular Weight94.971
SMILES
PubChem1061
Formal Charge-3
Total Atoms5
Total Chiral Atoms0
Total Bonds4
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41180
Sequence
>8SZH_nogp_Chain_R
YGPDQRAQK KGDIILGGL FPIHFGVAA KDQDLKSRP ESVECIRYN 
FRGFRWLQA MIFAIEEIN SSPALLPNL TLGYRIFDT CNTVSKALE 
ATLSFVAQN KIDSLNLCS EHIPSTIAV VGATGSGVS TAVANLLGL 
FYIPQVSYA SSSRLLSNK NQFKSFLRT IPNDEHQAT AMADIIEYF 
RWNWVGTIA ADDDYGRPG IEKFREEAE ERDICIDFS ELISQYSDE 
EEIQHVVEV IQNSTAKVI VVFSSGPDL EPLIKEIVR RNITGKIWL 
ASEAWASSS LIAMPQYFH VVGGTIGFA LKAGQIPGF REFLKKVHP 
RKSVHNGFA KEFWEETFN CHLQEFRPL CTGDENISS VETPYIDYT 
HLRISYNVY LAVYSIAHA LQDIYTCLP GRGLFTNGS CADIKKVEA 
WQVLKHLRH LNFTNNMGE QVTFDECGD LVGNYSIIN WHLSPEDGS 
IVFKEVGYY NVYAKKGER LFINEEKIL WSGFSREVP FSNCSRDCL 
AGTRKGIIE GEPTCCFEC VECPDGEYS DETDASACN KCPDDFWSN 
ENHTSCIAK EIEFLSWTE PFGIALTLF AVLGIFLTA FVLGVFIKF 
RNTPIVKAT NRELSYLLL FSLLCCFSS SLFFIGEPQ DWTCRLRQP 
AFGISFVLC ISCILVKTN RVLLVFEAK IPTSFHRKW WGLNLQFLL 
VFLCTFMQI VICVIWLYT APPSSYRNQ ELEDEIIFI TCHEGSLMA 
LGFLIGYTC LLAAICFFF AFKSRKLPE NFNEAKFIT FSMLIFFIV 
WISFIPAYA STYGKFVSA VEVIAILAA SFGLLACIF FNKIYIILF 
KPSRNTIEE VRCSTAAHA FKVAARA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP41180
Sequence
>8SZH_nogp_Chain_S
YGPDQRAQK KGDIILGGL FPIHFGVAA KDQDLKSRP ESVECIRYN 
FRGFRWLQA MIFAIEEIN SSPALLPNL TLGYRIFDT CNTVSKALE 
ATLSFVAQN KIDSLNLDC SEHIPSTIA VVGATGSGV STAVANLLG 
LFYIPQVSY ASSSRLLSN KNQFKSFLR TIPNDEHQA TAMADIIEY 
FRWNWVGTI AADDDYGRP GIEKFREEA EERDICIDF SELISQYSD 
EEEIQHVVE VIQNSTAKV IVVFSSGPD LEPLIKEIV RRNITGKIW 
LASEAWASS SLIAMPQYF HVVGGTIGF ALKAGQIPG FREFLKKVH 
PRKSVHNGF AKEFWEETF NCHLQERPL CTGDENISS VETPYIDYT 
HLRISYNVY LAVYSIAHA LQDIYTCLP GRGLFTNGS CADIKKVEA 
WQVLKHLRH LNFTNNMGE QVTFDECGD LVGNYSIIN WHLSPEDGS 
IVFKEVGYY NVYAKKGER LFINEEKIL WSGFSREVP FSNCSRDCL 
AGTRKGIIE GEPTCCFEC VECPDGEYS DETDASACN KCPDDFWSN 
ENHTSCIAK EIEFLSWTE PFGIALTLF AVLGIFLTA FVLGVFIKF 
RNTPIVKAT NRELSYLLL FSLLCCFSS SLFFIGEPQ DWTCRLRQP 
AFGISFVLC ISCILVKTN RVLLVFEAK NLQFLLVFL CTFMQIVIC 
VIWLYTAPP SSYRNQELE DEIIFITCH EGSLMALGF LIGYTCLLA 
AICFFFAFK SRKLPENFN EAKFITFSM LIFFIVWIS FIPAYASTY 
GKFVSAVEV IAILAASFG LLACIFFNK IYIILFKPS RNTIEEVRC 
ST


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9C2FCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Tryptophan; '6218; PO4-2.82024-10-0210.1126/science.ado1868
9C1PCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan; '6218; PO4-2.82024-10-0210.1126/science.ado1868
9AXFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.52024-04-1710.1038/s41586-024-07331-1
9AXF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.52024-04-1710.1038/s41586-024-07331-1
9ASBCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.42024-04-1710.1038/s41586-024-07331-1
9ASB (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.42024-04-1710.1038/s41586-024-07331-1
9AVGCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs)/β1/γ23.62024-04-1710.1038/s41586-024-07331-1
9AVG (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-1710.1038/s41586-024-07331-1
9AYFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4Gi1/β1/γ23.62024-04-1710.1038/s41586-024-07331-1
9AYF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-1710.1038/s41586-024-07331-1
9AVLCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4Gi3/β2/γ23.82024-04-1710.1038/s41586-024-07331-1
9AVL (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.82024-04-1710.1038/s41586-024-07331-1
8SZFCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-2.82024-02-0710.1038/s41586-024-07055-2
8SZGCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWchim(NtGi1-Gq)/β1/γ23.62024-02-0710.1038/s41586-024-07055-2
8SZG (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW3.62024-02-0710.1038/s41586-024-07055-2
8SZHCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWGi1/β1/γ23.12024-02-0710.1038/s41586-024-07055-2
8SZH (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW3.12024-02-0710.1038/s41586-024-07055-2
8SZICIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWGi3/β1/γ23.52024-02-0710.1038/s41586-024-07055-2
8SZI (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW3.52024-02-0710.1038/s41586-024-07055-2
8WPGCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca-2.72023-11-2210.1038/s41422-023-00892-2
8WPUCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(NtGi2L-Gs-CtGq)/β1/γ23.12023-11-2210.1038/s41422-023-00892-2
8WPU (No Gprot) CIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca3.12023-11-2210.1038/s41422-023-00892-2
7SINCIonCalcium SensingCaSHomo sapiens-NPS-2143-5.92022-01-1910.1073/pnas.2115849118
7SIMCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-2.72022-01-1910.1073/pnas.2115849118
7SILCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-2.72022-01-1910.1073/pnas.2115849118
7E6UCIonCalcium SensingCaSHomo sapiens---62021-09-2210.7554/eLife.68578
7E6TCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-32021-09-2210.7554/eLife.68578
7M3JCIonCalcium SensingCaSHomo sapiens-NPS-2143; PO4-4.12021-06-3010.1038/s41586-021-03691-0
7M3GCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4-2.52021-06-3010.1038/s41586-021-03691-0
7M3FCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4-2.82021-06-3010.1038/s41586-021-03691-0
7M3ECIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; NPS-2143-3.22021-06-3010.1038/s41586-021-03691-0
7DD7CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; Evocalcet-3.22021-06-1610.1126/sciadv.abg1483
7DD6CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan-3.22021-06-1610.1126/sciadv.abg1483
7DD5CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; NPS-2143-3.22021-06-1610.1126/sciadv.abg1483
7DTWCIonCalcium SensingCaSHomo sapiens---4.52021-03-1010.1038/s41422-021-00474-0
7DTVCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan-3.52021-03-1010.1038/s41422-021-00474-0
7DTUCIonCalcium SensingCaSHomo sapiens-Tryptophan-4.42021-03-1010.1038/s41422-021-00474-0
7DTTCIonCalcium SensingCaSHomo sapiensCaCa-3.82021-03-1010.1038/s41422-021-00474-0




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