CodePO4
NamePhosphate ion
Synonyms
  • Phosphate
  • Phosphate ion
  • Orthophosphate
Identifierphosphate
FormulaO4 P
Molecular Weight94.971
SMILES[O-]P(=O)([O-])[O-]
PubChem1061
Formal Charge-3
Total Atoms5
Total Chiral Atoms0
Total Bonds4
Total Aromatic Bonds0
Networks13
 missing image

This ligand is also present in the following 13 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7E6T C Ion Calcium-sensing CaS Homo sapiens Ca Ca; Ca; Cyclomethyltryptophan; PO4 - 3 2021-09-22 10.7554/eLife.68578

A 2D representation of the interactions of PO4 in 7E6T
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F38 R:R:W70 3.01 1 Yes Yes 7 5 2 1
R:R:F38 R:R:Y167 10.32 1 Yes Yes 7 8 2 2
R:R:P39 R:R:W70 5.4 1 Yes Yes 6 5 2 1
R:R:P39 R:R:T145 5.25 1 Yes Yes 6 5 2 2
R:R:P39 R:R:Y167 2.78 1 Yes Yes 6 8 2 2
R:R:R66 R:R:R69 7.46 1 Yes No 5 8 1 1
R:R:R66 R:R:W70 7 1 Yes Yes 5 5 1 1
R:R:I416 R:R:R66 2.51 1 Yes Yes 4 5 1 1
R:R:R66 W:W:?907 5.96 1 Yes Yes 5 0 1 2
R:R:R66 W:W:?901 6.99 1 Yes Yes 5 0 1 0
R:R:G67 R:R:W70 7.04 0 No Yes 4 5 2 1
R:R:R69 R:R:Y408 4.12 1 No Yes 8 3 1 2
R:R:R69 W:W:?901 16.77 1 No Yes 8 0 1 0
R:R:T145 R:R:W70 2.43 1 Yes Yes 5 5 2 1
R:R:W70 R:R:Y167 4.82 1 Yes Yes 5 8 1 2
R:R:I416 R:R:W70 17.62 1 Yes Yes 4 5 1 1
R:R:S417 R:R:W70 4.94 1 Yes Yes 6 5 1 1
R:R:W70 W:W:?901 9.17 1 Yes Yes 5 0 1 0
R:R:A73 R:R:F330 4.16 0 No Yes 7 8 2 2
R:R:A73 R:R:S417 3.42 0 No Yes 7 6 2 1
R:R:T145 R:R:Y167 6.24 1 Yes Yes 5 8 2 2
R:R:T145 W:W:?907 5.17 1 Yes Yes 5 0 2 2
R:R:I416 R:R:Y167 3.63 1 Yes Yes 4 8 1 2
R:R:A321 R:R:R415 5.53 0 No Yes 5 5 2 1
R:R:L322 R:R:R415 6.07 0 No Yes 4 5 2 1
R:R:F330 R:R:I327 3.77 1 Yes Yes 8 6 2 2
R:R:I327 R:R:L414 2.85 1 Yes Yes 6 6 2 1
R:R:F330 R:R:L414 3.65 1 Yes Yes 8 6 2 1
R:R:L414 R:R:Y411 11.72 1 Yes No 6 5 1 2
R:R:H413 R:R:R415 12.41 0 No Yes 7 5 2 1
R:R:L414 R:R:S417 4.5 1 Yes Yes 6 6 1 1
R:R:L414 W:W:?901 4.78 1 Yes Yes 6 0 1 0
R:R:R415 W:W:?901 4.19 0 Yes Yes 5 0 1 0
R:R:I416 W:W:?907 4 1 Yes Yes 4 0 1 2
R:R:I416 W:W:?901 11.49 1 Yes Yes 4 0 1 0
R:R:S417 W:W:?901 3.45 1 Yes Yes 6 0 1 0
R:R:N64 R:R:R66 2.41 0 No Yes 4 5 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.12
Average Nodes In Shell23.00
Average Hubs In Shell15.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PO4 in 7E6T
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F38 S:S:W70 3.01 2 Yes Yes 7 5 2 1
S:S:F38 S:S:Y167 9.28 2 Yes Yes 7 8 2 2
S:S:P39 S:S:W70 5.4 2 No Yes 6 5 2 1
S:S:P39 S:S:T145 12.24 2 No Yes 6 5 2 2
S:S:R66 S:S:R69 4.26 2 Yes Yes 5 8 1 1
S:S:R66 S:S:W70 16.99 2 Yes Yes 5 5 1 1
S:S:I416 S:S:R66 3.76 2 Yes Yes 4 5 1 1
S:S:R66 X:X:?907 2.55 2 Yes Yes 5 0 1 2
S:S:R66 X:X:?901 20.96 2 Yes Yes 5 0 1 0
S:S:G67 S:S:W70 7.04 0 No Yes 4 5 2 1
S:S:F330 S:S:R69 3.21 2 Yes Yes 8 8 2 1
S:S:R69 S:S:Y408 4.12 2 Yes Yes 8 3 1 2
S:S:L414 S:S:R69 2.43 2 Yes Yes 6 8 1 1
S:S:R69 X:X:?901 8.38 2 Yes Yes 8 0 1 0
S:S:T145 S:S:W70 3.64 2 Yes Yes 5 5 2 1
S:S:W70 S:S:Y167 5.79 2 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 19.97 2 Yes Yes 4 5 1 1
S:S:S417 S:S:W70 4.94 2 Yes Yes 6 5 1 1
S:S:W70 X:X:?901 7.86 2 Yes Yes 5 0 1 0
S:S:A73 S:S:F330 4.16 0 No Yes 7 8 2 2
S:S:A73 S:S:S417 3.42 0 No Yes 7 6 2 1
S:S:T145 S:S:Y167 2.5 2 Yes Yes 5 8 2 2
S:S:I416 S:S:Y167 3.63 2 Yes Yes 4 8 1 2
S:S:A321 S:S:R415 5.53 0 No Yes 5 5 2 1
S:S:L322 S:S:R415 2.43 2 Yes Yes 4 5 2 1
S:S:F330 S:S:I327 3.77 2 Yes No 8 6 2 2
S:S:I327 S:S:L414 2.85 2 No Yes 6 6 2 1
S:S:F330 S:S:L414 3.65 2 Yes Yes 8 6 2 1
S:S:L414 S:S:Y411 9.38 2 Yes No 6 5 1 2
S:S:H413 S:S:R415 5.64 0 No Yes 7 5 2 1
S:S:L414 S:S:S417 4.5 2 Yes Yes 6 6 1 1
S:S:L414 X:X:?901 7.96 2 Yes Yes 6 0 1 0
S:S:R415 X:X:?901 2.79 0 Yes Yes 5 0 1 0
S:S:I416 X:X:?901 6.57 2 Yes Yes 4 0 1 0
S:S:S417 X:X:?901 6.91 2 Yes Yes 6 0 1 0
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.78
Average Nodes In Shell22.00
Average Hubs In Shell15.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7M3J C Ion Calcium-sensing CaS Homo sapiens - NPS-2143; PO4 - 4.1 2021-06-30 10.1038/s41586-021-03691-0

A 2D representation of the interactions of PO4 in 7M3J
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F38 R:R:W70 2 1 Yes Yes 7 5 2 1
R:R:F38 R:R:Y167 12.38 1 Yes Yes 7 8 2 2
R:R:P39 R:R:W70 4.05 1 No Yes 6 5 2 1
R:R:P39 R:R:T145 10.49 1 No Yes 6 5 2 2
R:R:N64 R:R:R66 3.62 0 No Yes 4 5 2 1
R:R:G67 R:R:N64 3.39 0 No No 4 4 2 2
R:R:R66 R:R:R69 4.26 1 Yes Yes 5 8 1 1
R:R:R66 R:R:W70 10 1 Yes Yes 5 5 1 1
R:R:R66 W:W:?905 19.56 1 Yes Yes 5 0 1 0
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:F330 R:R:R69 2.14 1 Yes Yes 8 8 2 1
R:R:L334 R:R:R69 3.64 1 Yes Yes 6 8 2 1
R:R:R69 R:R:Y408 2.06 1 Yes Yes 8 3 1 2
R:R:R69 R:R:Y411 4.12 1 Yes Yes 8 5 1 2
R:R:R69 W:W:?905 12.58 1 Yes Yes 8 0 1 0
R:R:T145 R:R:W70 7.28 1 Yes Yes 5 5 2 1
R:R:W70 R:R:Y167 1.93 1 Yes Yes 5 8 1 2
R:R:I416 R:R:W70 7.05 1 No Yes 4 5 1 1
R:R:S417 R:R:W70 3.71 1 Yes Yes 6 5 1 1
R:R:W70 W:W:?905 6.55 1 Yes Yes 5 0 1 0
R:R:A73 R:R:F330 2.77 0 No Yes 7 8 2 2
R:R:A73 R:R:S417 1.71 0 No Yes 7 6 2 1
R:R:T145 R:R:Y167 13.73 1 Yes Yes 5 8 2 2
R:R:I187 R:R:I416 1.47 1 Yes No 6 4 2 1
R:R:A321 R:R:R415 4.15 24 No No 5 5 2 1
R:R:F330 R:R:I327 3.77 1 Yes No 8 6 2 2
R:R:I327 R:R:L414 8.56 0 No Yes 6 6 2 1
R:R:F330 R:R:L334 8.53 1 Yes Yes 8 6 2 2
R:R:L334 R:R:Y408 8.21 1 Yes Yes 6 3 2 2
R:R:L334 R:R:Y411 3.52 1 Yes Yes 6 5 2 2
R:R:L414 R:R:Y411 7.03 1 Yes Yes 6 5 1 2
R:R:H413 R:R:R415 11.28 0 No No 7 5 2 1
R:R:L414 R:R:S417 3 1 Yes Yes 6 6 1 1
R:R:L414 W:W:?905 3.18 1 Yes Yes 6 0 1 0
R:R:R415 W:W:?905 2.79 0 No Yes 5 0 1 0
R:R:I416 W:W:?905 3.28 1 No Yes 4 0 1 0
R:R:S417 W:W:?905 6.91 1 Yes Yes 6 0 1 0
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.84
Average Nodes In Shell23.00
Average Hubs In Shell14.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PO4 in 7M3J
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F38 S:S:P39 4.33 2 Yes Yes 7 6 2 2
S:S:F38 S:S:W70 2 2 Yes Yes 7 5 2 1
S:S:F38 S:S:Y167 10.32 2 Yes Yes 7 8 2 2
S:S:P39 S:S:W70 2.7 2 Yes Yes 6 5 2 1
S:S:P39 S:S:T145 6.99 2 Yes Yes 6 5 2 2
S:S:N64 S:S:R66 3.62 0 No Yes 4 5 2 1
S:S:G67 S:S:N64 3.39 0 No No 4 4 2 2
S:S:R66 S:S:R69 2.13 2 Yes Yes 5 8 1 1
S:S:R66 S:S:W70 11 2 Yes Yes 5 5 1 1
S:S:R66 X:X:?904 20.96 2 Yes Yes 5 0 1 0
S:S:G67 S:S:W70 5.63 0 No Yes 4 5 2 1
S:S:F330 S:S:R69 3.21 2 Yes Yes 8 8 2 1
S:S:L334 S:S:R69 3.64 2 Yes Yes 6 8 2 1
S:S:R69 S:S:Y408 2.06 2 Yes Yes 8 3 1 2
S:S:R69 S:S:Y411 12.35 2 Yes No 8 5 1 2
S:S:R69 X:X:?904 15.37 2 Yes Yes 8 0 1 0
S:S:T145 S:S:W70 2.43 2 Yes Yes 5 5 2 1
S:S:W70 S:S:Y167 2.89 2 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 9.4 2 No Yes 4 5 1 1
S:S:W70 X:X:?904 7.86 2 Yes Yes 5 0 1 0
S:S:A73 S:S:F330 2.77 2 No Yes 7 8 2 2
S:S:A73 S:S:S417 3.42 2 No Yes 7 6 2 1
S:S:T145 S:S:Y167 7.49 2 Yes Yes 5 8 2 2
S:S:F330 S:S:I327 2.51 2 Yes Yes 8 6 2 2
S:S:I327 S:S:L414 2.85 2 Yes Yes 6 6 2 1
S:S:I327 S:S:S417 1.55 2 Yes Yes 6 6 2 1
S:S:F330 S:S:L334 12.18 2 Yes Yes 8 6 2 2
S:S:F330 S:S:S417 2.64 2 Yes Yes 8 6 2 1
S:S:L334 S:S:Y408 8.21 2 Yes Yes 6 3 2 2
S:S:L414 S:S:Y411 8.21 2 Yes No 6 5 1 2
S:S:L414 S:S:S417 3 2 Yes Yes 6 6 1 1
S:S:L414 X:X:?904 1.59 2 Yes Yes 6 0 1 0
S:S:I416 X:X:?904 6.57 2 No Yes 4 0 1 0
S:S:S417 X:X:?904 1.73 2 Yes Yes 6 0 1 0
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.01
Average Nodes In Shell19.00
Average Hubs In Shell14.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SIL C Ion Calcium-sensing CaS Homo sapiens Ca Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 - 2.7 2022-01-19 10.1073/pnas.2115849118

A 2D representation of the interactions of PO4 in 7SIL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P39 R:R:W70 5.4 1 Yes Yes 6 5 2 1
R:R:P39 R:R:T145 10.49 1 Yes Yes 6 5 2 2
R:R:R66 R:R:R69 6.4 1 Yes Yes 5 8 1 1
R:R:R66 R:R:W70 13 1 Yes Yes 5 5 1 1
R:R:R66 W:W:?2 5.96 1 Yes Yes 5 0 1 2
R:R:R66 W:W:?3 19.56 1 Yes Yes 5 0 1 0
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:L334 R:R:R69 3.64 1 Yes Yes 6 8 2 1
R:R:R69 R:R:Y411 12.35 1 Yes Yes 8 5 1 2
R:R:R69 R:R:S417 6.59 1 Yes Yes 8 6 1 1
R:R:R69 W:W:?3 13.97 1 Yes Yes 8 0 1 0
R:R:T145 R:R:W70 6.06 1 Yes Yes 5 5 2 1
R:R:W70 R:R:Y167 4.82 1 Yes Yes 5 8 1 2
R:R:I416 R:R:W70 21.14 1 Yes Yes 4 5 1 1
R:R:S417 R:R:W70 4.94 1 Yes Yes 6 5 1 1
R:R:W70 W:W:?2 6.39 1 Yes Yes 5 0 1 2
R:R:W70 W:W:?3 9.17 1 Yes Yes 5 0 1 0
R:R:A73 R:R:S417 3.42 0 No Yes 7 6 2 1
R:R:T145 R:R:Y167 9.99 1 Yes Yes 5 8 2 2
R:R:A168 R:R:T145 3.36 1 No Yes 5 5 2 2
R:R:T145 W:W:?2 5.17 1 Yes Yes 5 0 2 2
R:R:A168 R:R:I416 3.25 1 No Yes 5 4 2 1
R:R:A168 W:W:?2 3.31 1 No Yes 5 0 2 2
R:R:E297 R:R:I416 4.1 1 Yes Yes 8 4 2 1
R:R:E297 W:W:?2 11.15 1 Yes Yes 8 0 2 2
R:R:A321 R:R:R415 6.91 0 No No 5 5 2 1
R:R:L334 R:R:Y411 3.52 1 Yes Yes 6 5 2 2
R:R:L414 R:R:Y411 11.72 1 Yes Yes 6 5 2 2
R:R:H413 R:R:R415 13.54 0 No No 7 5 2 1
R:R:L414 R:R:S417 4.5 1 Yes Yes 6 6 2 1
R:R:I416 W:W:?2 4 1 Yes Yes 4 0 1 2
R:R:I416 W:W:?3 9.85 1 Yes Yes 4 0 1 0
R:R:S417 W:W:?3 6.91 1 Yes Yes 6 0 1 0
R:R:R415 W:W:?3 2.79 0 No Yes 5 0 1 0
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength10.38
Average Nodes In Shell20.00
Average Hubs In Shell14.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PO4 in 7SIL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:P39 S:S:W70 5.4 2 Yes Yes 6 5 2 1
S:S:P39 S:S:T145 10.49 2 Yes Yes 6 5 2 2
S:S:R66 S:S:R69 6.4 2 Yes Yes 5 8 1 1
S:S:R66 S:S:W70 13 2 Yes Yes 5 5 1 1
S:S:R66 X:X:?2 5.96 2 Yes Yes 5 0 1 2
S:S:R66 X:X:?3 19.56 2 Yes Yes 5 0 1 0
S:S:G67 S:S:W70 5.63 0 No Yes 4 5 2 1
S:S:L334 S:S:R69 3.64 2 Yes Yes 6 8 2 1
S:S:R69 S:S:Y411 12.35 2 Yes Yes 8 5 1 2
S:S:R69 S:S:S417 6.59 2 Yes Yes 8 6 1 1
S:S:R69 X:X:?3 13.97 2 Yes Yes 8 0 1 0
S:S:T145 S:S:W70 6.06 2 Yes Yes 5 5 2 1
S:S:W70 S:S:Y167 4.82 2 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 21.14 2 Yes Yes 4 5 1 1
S:S:S417 S:S:W70 4.94 2 Yes Yes 6 5 1 1
S:S:W70 X:X:?2 6.39 2 Yes Yes 5 0 1 2
S:S:W70 X:X:?3 9.17 2 Yes Yes 5 0 1 0
S:S:A73 S:S:S417 3.42 0 No Yes 7 6 2 1
S:S:T145 S:S:Y167 9.99 2 Yes Yes 5 8 2 2
S:S:A168 S:S:T145 3.36 2 No Yes 5 5 2 2
S:S:T145 X:X:?2 5.17 2 Yes Yes 5 0 2 2
S:S:A168 S:S:I416 3.25 2 No Yes 5 4 2 1
S:S:A168 X:X:?2 3.31 2 No Yes 5 0 2 2
S:S:E297 S:S:I416 5.47 2 Yes Yes 8 4 2 1
S:S:E297 X:X:?2 11.15 2 Yes Yes 8 0 2 2
S:S:A321 S:S:R415 6.91 0 No No 5 5 2 1
S:S:L334 S:S:Y411 3.52 2 Yes Yes 6 5 2 2
S:S:L414 S:S:Y411 10.55 2 Yes Yes 6 5 2 2
S:S:H413 S:S:R415 13.54 0 No No 7 5 2 1
S:S:L414 S:S:S417 4.5 2 Yes Yes 6 6 2 1
S:S:I416 X:X:?2 4 2 Yes Yes 4 0 1 2
S:S:I416 X:X:?3 9.85 2 Yes Yes 4 0 1 0
S:S:S417 X:X:?3 6.91 2 Yes Yes 6 0 1 0
S:S:R415 X:X:?3 2.79 0 No Yes 5 0 1 0
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength10.38
Average Nodes In Shell20.00
Average Hubs In Shell14.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SIM C Ion Calcium-sensing CaS Homo sapiens Ca Ca; Ca; Cyclomethyltryptophan; PO4 - 2.7 2022-01-19 10.1073/pnas.2115849118

A 2D representation of the interactions of PO4 in 7SIM
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P39 R:R:W70 5.4 1 Yes Yes 6 5 2 1
R:R:P39 R:R:T145 10.49 1 Yes Yes 6 5 2 2
R:R:R66 R:R:R69 5.33 1 Yes Yes 5 8 1 1
R:R:R66 R:R:W70 12 1 Yes Yes 5 5 1 1
R:R:R66 W:W:?1 5.96 1 Yes Yes 5 0 1 2
R:R:R66 W:W:?2 18.17 1 Yes Yes 5 0 1 0
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:L334 R:R:R69 3.64 1 Yes Yes 6 8 2 1
R:R:R69 R:R:Y411 13.38 1 Yes Yes 8 5 1 2
R:R:R69 R:R:S417 6.59 1 Yes Yes 8 6 1 1
R:R:R69 W:W:?2 12.58 1 Yes Yes 8 0 1 0
R:R:T145 R:R:W70 6.06 1 Yes Yes 5 5 2 1
R:R:W70 R:R:Y167 6.75 1 Yes Yes 5 8 1 2
R:R:I416 R:R:W70 21.14 1 Yes Yes 4 5 1 1
R:R:S417 R:R:W70 4.94 1 Yes Yes 6 5 1 1
R:R:W70 W:W:?1 5.59 1 Yes Yes 5 0 1 2
R:R:W70 W:W:?2 9.17 1 Yes Yes 5 0 1 0
R:R:T145 R:R:Y167 7.49 1 Yes Yes 5 8 2 2
R:R:T145 W:W:?1 5.17 1 Yes Yes 5 0 2 2
R:R:I416 R:R:Y167 4.84 1 Yes Yes 4 8 1 2
R:R:E297 R:R:I416 4.1 1 Yes Yes 8 4 2 1
R:R:E297 W:W:?1 11.15 1 Yes Yes 8 0 2 2
R:R:L334 R:R:Y411 3.52 1 Yes Yes 6 5 2 2
R:R:L414 R:R:Y411 12.89 1 Yes Yes 6 5 2 2
R:R:L414 R:R:S417 6.01 1 Yes Yes 6 6 2 1
R:R:I416 W:W:?1 4 1 Yes Yes 4 0 1 2
R:R:I416 W:W:?2 9.85 1 Yes Yes 4 0 1 0
R:R:S417 W:W:?2 6.91 1 Yes Yes 6 0 1 0
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub5.00
Average Interaction Strength11.34
Average Nodes In Shell15.00
Average Hubs In Shell14.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PO4 in 7SIM
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:P39 S:S:W70 5.4 2 Yes Yes 6 5 2 1
S:S:P39 S:S:T145 10.49 2 Yes Yes 6 5 2 2
S:S:R66 S:S:R69 5.33 2 Yes Yes 5 8 1 1
S:S:R66 S:S:W70 12 2 Yes Yes 5 5 1 1
S:S:R66 X:X:?1 5.96 2 Yes Yes 5 0 1 2
S:S:R66 X:X:?2 18.17 2 Yes Yes 5 0 1 0
S:S:G67 S:S:W70 5.63 0 No Yes 4 5 2 1
S:S:L334 S:S:R69 3.64 2 Yes Yes 6 8 2 1
S:S:R69 S:S:Y411 13.38 2 Yes Yes 8 5 1 2
S:S:R69 S:S:S417 6.59 2 Yes Yes 8 6 1 1
S:S:R69 X:X:?2 12.58 2 Yes Yes 8 0 1 0
S:S:T145 S:S:W70 6.06 2 Yes Yes 5 5 2 1
S:S:W70 S:S:Y167 6.75 2 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 21.14 2 Yes Yes 4 5 1 1
S:S:S417 S:S:W70 4.94 2 Yes Yes 6 5 1 1
S:S:W70 X:X:?1 5.59 2 Yes Yes 5 0 1 2
S:S:W70 X:X:?2 9.17 2 Yes Yes 5 0 1 0
S:S:T145 S:S:Y167 9.99 2 Yes Yes 5 8 2 2
S:S:T145 X:X:?1 4.13 2 Yes Yes 5 0 2 2
S:S:I416 S:S:Y167 3.63 2 Yes Yes 4 8 1 2
S:S:E297 S:S:I416 4.1 2 Yes Yes 8 4 2 1
S:S:E297 X:X:?1 13.01 2 Yes Yes 8 0 2 2
S:S:L334 S:S:Y411 3.52 2 Yes Yes 6 5 2 2
S:S:L414 S:S:Y411 12.89 2 Yes Yes 6 5 2 2
S:S:L414 S:S:S417 6.01 2 Yes Yes 6 6 2 1
S:S:I416 X:X:?1 4 2 Yes Yes 4 0 1 2
S:S:I416 X:X:?2 8.21 2 Yes Yes 4 0 1 0
S:S:S417 X:X:?2 6.91 2 Yes Yes 6 0 1 0
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub5.00
Average Interaction Strength11.01
Average Nodes In Shell15.00
Average Hubs In Shell14.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JXT A Amine Histamine H4 Homo Sapiens Histamine PO4 Gi1/Beta1/Gamma2 3.07 2024-03-20 10.1038/s41467-024-46840-5

A 2D representation of the interactions of PO4 in 8JXT
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D94 R:R:W348 12.28 2 No Yes 8 8 2 2
L:L:?1 R:R:D94 11.06 2 Yes No 0 8 1 2
R:R:N147 R:R:Y95 15.12 0 No Yes 8 8 2 1
R:R:I151 R:R:Y95 2.42 0 Yes Yes 7 8 2 1
R:R:P166 R:R:Y95 6.95 2 Yes Yes 7 8 2 1
R:R:F168 R:R:Y95 3.09 2 Yes Yes 6 8 2 1
L:L:?1 R:R:Y95 12.74 2 Yes Yes 0 8 1 1
R:R:Y95 W:W:?1 8.09 2 Yes Yes 8 0 1 0
R:R:C98 R:R:W316 2.61 0 No Yes 8 9 2 1
R:R:C98 R:R:W348 2.61 0 No Yes 8 8 2 2
R:R:E182 R:R:T99 2.82 2 Yes No 8 8 1 2
R:R:E182 R:R:V102 4.28 2 Yes Yes 8 8 1 2
R:R:F312 R:R:V102 7.87 2 Yes Yes 9 8 2 2
R:R:V102 R:R:W316 7.36 2 Yes Yes 8 9 2 1
R:R:F168 R:R:P166 10.11 2 Yes Yes 6 7 2 2
R:R:S179 R:R:S320 3.26 0 No No 8 8 2 1
R:R:E182 R:R:W316 10.9 2 Yes Yes 8 9 1 1
R:R:E182 W:W:?1 18.29 2 Yes Yes 8 0 1 0
R:R:F183 R:R:W316 2 0 No Yes 9 9 2 1
R:R:F312 R:R:W316 3.01 2 Yes Yes 9 9 2 1
R:R:F312 R:R:N350 2.42 2 Yes No 9 9 2 2
R:R:Q347 R:R:W316 24.09 2 No Yes 8 9 2 1
R:R:N350 R:R:W316 7.91 2 No Yes 9 9 2 1
R:R:W316 W:W:?1 6.55 2 Yes Yes 9 0 1 0
R:R:F344 R:R:Y319 10.32 2 No Yes 6 7 2 2
R:R:Q347 R:R:Y319 3.38 2 No Yes 8 7 2 2
L:L:?1 R:R:Y319 4.25 2 Yes Yes 0 7 1 2
R:R:F344 R:R:W348 2 2 No Yes 6 8 2 2
L:L:?1 R:R:F344 20.96 2 Yes No 0 6 1 2
L:L:?1 R:R:Q347 6.03 2 Yes No 0 8 1 2
L:L:?1 R:R:W348 11.35 2 Yes Yes 0 8 1 2
L:L:?1 W:W:?1 4.33 2 Yes Yes 0 0 1 0
R:R:S320 W:W:?1 1.73 0 No Yes 8 0 1 0
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.80
Average Nodes In Shell22.00
Average Hubs In Shell12.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8SZF C Ion Calcium-sensing CaS Homo sapiens - Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW - 2.8 2024-02-07 10.1038/s41586-024-07055-2

A 2D representation of the interactions of PO4 in 8SZF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:R66 R:R:R69 5.33 2 Yes Yes 5 8 1 1
R:R:R66 R:R:W70 9 2 Yes Yes 5 5 1 1
R:R:R66 W:W:W1 6 2 Yes Yes 5 0 1 2
R:R:R66 W:W:?5 16.77 2 Yes Yes 5 0 1 0
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:L334 R:R:R69 3.64 2 Yes Yes 6 8 2 1
R:R:R69 R:R:Y411 10.29 2 Yes No 8 5 1 2
R:R:R69 W:W:?5 8.38 2 Yes Yes 8 0 1 0
R:R:T145 R:R:W70 3.64 2 Yes Yes 5 5 2 1
R:R:I416 R:R:W70 17.62 2 No Yes 4 5 1 1
R:R:W70 W:W:W1 2.81 2 Yes Yes 5 0 1 2
R:R:W70 W:W:?5 9.17 2 Yes Yes 5 0 1 0
R:R:T145 W:W:W1 4.85 2 Yes Yes 5 0 2 2
R:R:A321 R:R:R415 6.91 0 No Yes 5 5 2 1
R:R:A324 R:R:H413 4.39 2 No No 5 7 2 2
R:R:A324 R:R:R415 2.77 2 No Yes 5 5 2 1
R:R:F330 R:R:I327 5.02 2 Yes Yes 8 6 2 2
R:R:I327 R:R:L414 4.28 2 Yes Yes 6 6 2 1
R:R:F330 R:R:L334 14.61 2 Yes Yes 8 6 2 2
R:R:F330 R:R:L414 3.65 2 Yes Yes 8 6 2 1
R:R:L414 R:R:Y411 9.38 2 Yes No 6 5 1 2
R:R:H413 R:R:R415 10.16 2 No Yes 7 5 2 1
R:R:L414 R:R:S417 4.5 2 Yes No 6 6 1 1
R:R:L414 W:W:?5 3.18 2 Yes Yes 6 0 1 0
R:R:R415 W:W:?5 5.59 2 Yes Yes 5 0 1 0
R:R:I416 W:W:?5 8.21 2 No Yes 4 0 1 0
R:R:S417 W:W:?5 6.91 2 No Yes 6 0 1 0
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.32
Average Nodes In Shell18.00
Average Hubs In Shell11.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PO4 in 8SZF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:R66 S:S:R69 3.2 1 Yes Yes 5 8 1 1
S:S:R66 S:S:W70 9 1 Yes Yes 5 5 1 1
K:K:W1 S:S:R66 5 1 Yes Yes 0 5 2 1
K:K:?3 S:S:R66 15.37 1 Yes Yes 0 5 0 1
S:S:G67 S:S:W70 5.63 0 No Yes 4 5 2 1
S:S:L334 S:S:R69 3.64 1 Yes Yes 6 8 2 1
S:S:R69 S:S:Y411 11.32 1 Yes No 8 5 1 2
K:K:?3 S:S:R69 8.38 1 Yes Yes 0 8 0 1
S:S:I416 S:S:W70 14.09 1 No Yes 4 5 1 1
S:S:S417 S:S:W70 4.94 1 No Yes 6 5 1 1
K:K:?3 S:S:W70 9.17 1 Yes Yes 0 5 0 1
S:S:A321 S:S:R415 5.53 0 No No 5 5 2 1
S:S:F330 S:S:I327 5.02 1 Yes Yes 8 6 2 2
S:S:I327 S:S:L414 2.85 1 Yes Yes 6 6 2 1
S:S:F330 S:S:L334 14.61 1 Yes Yes 8 6 2 2
S:S:F330 S:S:L414 3.65 1 Yes Yes 8 6 2 1
S:S:L414 S:S:Y411 8.21 1 Yes No 6 5 1 2
S:S:H413 S:S:R415 13.54 0 No No 7 5 2 1
S:S:L414 S:S:S417 4.5 1 Yes No 6 6 1 1
K:K:?3 S:S:L414 3.18 1 Yes Yes 0 6 0 1
K:K:?3 S:S:R415 2.79 1 Yes No 0 5 0 1
K:K:?3 S:S:I416 6.57 1 Yes No 0 4 0 1
K:K:?3 S:S:S417 6.91 1 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.48
Average Nodes In Shell16.00
Average Hubs In Shell9.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell21.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8SZG C Ion Calcium-sensing CaS Homo sapiens - Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW chim(NtGi1-Gq)/Beta1/Gamma2 3.6 2024-02-07 10.1038/s41586-024-07055-2

A 2D representation of the interactions of PO4 in 8SZG
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F38 R:R:W70 2 1 Yes Yes 7 5 2 1
R:R:F38 R:R:Y167 11.35 1 Yes Yes 7 8 2 2
R:R:N64 R:R:R66 2.41 0 No Yes 4 5 2 1
R:R:G67 R:R:N64 3.39 0 No No 4 4 2 2
R:R:R66 R:R:R69 4.26 1 Yes Yes 5 8 1 1
R:R:R66 R:R:W70 11 1 Yes Yes 5 5 1 1
R:R:R66 W:W:W5 3 1 Yes Yes 5 0 1 2
R:R:R66 W:W:?6 13.97 1 Yes Yes 5 0 1 0
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:L334 R:R:R69 3.64 1 Yes Yes 6 8 2 1
R:R:R69 R:R:Y411 9.26 1 Yes Yes 8 5 1 2
R:R:R69 W:W:?6 8.38 1 Yes Yes 8 0 1 0
R:R:T145 R:R:W70 3.64 1 Yes Yes 5 5 2 1
R:R:W70 R:R:Y167 2.89 1 Yes Yes 5 8 1 2
R:R:I416 R:R:W70 16.44 1 No Yes 4 5 1 1
R:R:S417 R:R:W70 2.47 1 Yes Yes 6 5 1 1
R:R:W70 W:W:?6 7.86 1 Yes Yes 5 0 1 0
R:R:A73 R:R:S417 1.71 0 No Yes 7 6 2 1
R:R:T145 R:R:Y167 3.75 1 Yes Yes 5 8 2 2
R:R:T145 W:W:W5 6.06 1 Yes Yes 5 0 2 2
R:R:I416 R:R:Y167 2.42 1 No Yes 4 8 1 2
R:R:A321 R:R:R415 2.77 0 No Yes 5 5 2 1
R:R:L322 R:R:R415 2.43 0 Yes Yes 4 5 2 1
R:R:A324 R:R:H413 4.39 1 No No 5 7 2 2
R:R:A324 R:R:R415 2.77 1 No Yes 5 5 2 1
R:R:L334 R:R:Y411 3.52 1 Yes Yes 6 5 2 2
R:R:L414 R:R:Y411 4.69 1 Yes Yes 6 5 2 2
R:R:H413 R:R:R415 9.03 1 No Yes 7 5 2 1
R:R:L414 R:R:S417 4.5 1 Yes Yes 6 6 2 1
R:R:R415 W:W:?6 4.19 1 Yes Yes 5 0 1 0
R:R:I416 W:W:?6 3.28 1 No Yes 4 0 1 0
R:R:S417 W:W:?6 3.45 1 Yes Yes 6 0 1 0
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength6.86
Average Nodes In Shell21.00
Average Hubs In Shell14.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PO4 in 8SZG
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F38 S:S:W70 2 2 Yes Yes 7 5 2 1
S:S:F38 S:S:Y167 10.32 2 Yes Yes 7 8 2 2
S:S:N64 S:S:R66 2.41 0 No Yes 4 5 2 1
S:S:R66 S:S:R69 4.26 2 Yes Yes 5 8 1 1
S:S:R66 S:S:W70 6 2 Yes Yes 5 5 1 1
K:K:W1 S:S:R66 2 2 Yes Yes 0 5 2 1
K:K:?2 S:S:R66 16.77 2 Yes Yes 0 5 0 1
S:S:L334 S:S:R69 2.43 2 Yes Yes 6 8 2 1
S:S:R69 S:S:Y408 2.06 2 Yes Yes 8 3 1 2
S:S:R69 S:S:Y411 8.23 2 Yes Yes 8 5 1 2
K:K:?2 S:S:R69 9.78 2 Yes Yes 0 8 0 1
S:S:T145 S:S:W70 2.43 2 Yes Yes 5 5 2 1
S:S:W70 S:S:Y167 3.86 2 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 14.09 2 Yes Yes 4 5 1 1
S:S:S417 S:S:W70 2.47 2 No Yes 6 5 1 1
K:K:?2 S:S:W70 7.86 2 Yes Yes 0 5 0 1
S:S:T145 S:S:Y167 3.75 2 Yes Yes 5 8 2 2
S:S:I416 S:S:Y167 2.42 2 Yes Yes 4 8 1 2
S:S:E297 S:S:I416 2.73 2 Yes Yes 8 4 2 1
K:K:W1 S:S:E297 5.45 2 Yes Yes 0 8 2 2
S:S:A321 S:S:R415 5.53 0 No No 5 5 2 1
S:S:F330 S:S:I327 3.77 2 Yes Yes 8 6 2 2
S:S:I327 S:S:L414 4.28 2 Yes Yes 6 6 2 1
S:S:F330 S:S:L334 9.74 2 Yes Yes 8 6 2 2
S:S:F330 S:S:L414 2.44 2 Yes Yes 8 6 2 1
S:S:L334 S:S:Y408 4.69 2 Yes Yes 6 3 2 2
S:S:L334 S:S:Y411 2.34 2 Yes Yes 6 5 2 2
S:S:L414 S:S:Y411 5.86 2 Yes Yes 6 5 1 2
S:S:H413 S:S:R415 10.16 0 No No 7 5 2 1
S:S:L414 S:S:S417 7.51 2 Yes No 6 6 1 1
K:K:?2 S:S:L414 3.18 2 Yes Yes 0 6 0 1
K:K:?2 S:S:R415 2.79 2 Yes No 0 5 0 1
K:K:W1 S:S:I416 2.35 2 Yes Yes 0 4 2 1
K:K:?2 S:S:I416 8.21 2 Yes Yes 0 4 0 1
K:K:?2 S:S:S417 5.18 2 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.68
Average Nodes In Shell21.00
Average Hubs In Shell16.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8SZH C Ion Calcium-sensing CaS Homo sapiens - Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW Gi1/Beta1/Gamma2 3.1 2024-02-07 10.1038/s41586-024-07055-2

A 2D representation of the interactions of PO4 in 8SZH
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F38 R:R:W70 2 1 Yes Yes 7 5 2 1
R:R:F38 R:R:Y167 9.28 1 Yes Yes 7 8 2 2
R:R:R66 R:R:R69 5.33 1 Yes Yes 5 8 1 1
R:R:R66 R:R:W70 12 1 Yes Yes 5 5 1 1
R:R:R66 W:W:W5 3 1 Yes Yes 5 0 1 2
R:R:R66 W:W:?6 16.77 1 Yes Yes 5 0 1 0
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:F330 R:R:R69 3.21 1 Yes Yes 8 8 2 1
R:R:L334 R:R:R69 3.64 1 Yes Yes 6 8 2 1
R:R:R69 R:R:Y411 9.26 1 Yes Yes 8 5 1 2
R:R:R69 R:R:S417 2.64 1 Yes Yes 8 6 1 1
R:R:R69 W:W:?6 9.78 1 Yes Yes 8 0 1 0
R:R:T145 R:R:W70 3.64 1 Yes Yes 5 5 2 1
R:R:W70 R:R:Y167 2.89 1 Yes Yes 5 8 1 2
R:R:I416 R:R:W70 18.79 1 No Yes 4 5 1 1
R:R:S417 R:R:W70 2.47 1 Yes Yes 6 5 1 1
R:R:W70 W:W:?6 7.86 1 Yes Yes 5 0 1 0
R:R:A73 R:R:S417 1.71 0 No Yes 7 6 2 1
R:R:T145 R:R:Y167 4.99 1 Yes Yes 5 8 2 2
R:R:T145 W:W:W5 4.85 1 Yes Yes 5 0 2 2
R:R:I416 R:R:Y167 2.42 1 No Yes 4 8 1 2
R:R:A321 R:R:R415 5.53 0 No Yes 5 5 2 1
R:R:L322 R:R:R415 2.43 0 Yes Yes 4 5 2 1
R:R:F330 R:R:I327 7.54 1 Yes Yes 8 6 2 2
R:R:I327 R:R:L414 4.28 1 Yes Yes 6 6 2 1
R:R:F330 R:R:L334 17.05 1 Yes Yes 8 6 2 2
R:R:F330 R:R:L414 3.65 1 Yes Yes 8 6 2 1
R:R:L334 R:R:Y411 3.52 1 Yes Yes 6 5 2 2
R:R:L414 R:R:Y411 7.03 1 Yes Yes 6 5 1 2
R:R:H413 R:R:R415 13.54 0 No Yes 7 5 2 1
R:R:L414 R:R:S417 4.5 1 Yes Yes 6 6 1 1
R:R:L414 W:W:?6 1.59 1 Yes Yes 6 0 1 0
R:R:R415 W:W:?6 6.99 0 Yes Yes 5 0 1 0
R:R:I416 W:W:?6 11.49 1 No Yes 4 0 1 0
R:R:S417 W:W:?6 5.18 1 Yes Yes 6 0 1 0
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.52
Average Nodes In Shell21.00
Average Hubs In Shell16.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PO4 in 8SZH
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F38 S:S:W70 2 1 Yes Yes 7 5 2 1
S:S:F38 S:S:Y167 10.32 1 Yes Yes 7 8 2 2
S:S:R66 S:S:R69 5.33 1 Yes Yes 5 8 1 1
S:S:R66 S:S:W70 10 1 Yes Yes 5 5 1 1
S:S:I416 S:S:R66 2.51 1 No Yes 4 5 1 1
K:K:?6 S:S:R66 15.37 1 Yes Yes 0 5 0 1
S:S:G67 S:S:W70 4.22 0 No Yes 4 5 2 1
S:S:F330 S:S:R69 2.14 1 Yes Yes 8 8 2 1
S:S:L334 S:S:R69 3.64 1 Yes Yes 6 8 2 1
S:S:R69 S:S:Y411 11.32 1 Yes Yes 8 5 1 2
K:K:?6 S:S:R69 11.18 1 Yes Yes 0 8 0 1
S:S:T145 S:S:W70 2.43 1 Yes Yes 5 5 2 1
S:S:W70 S:S:Y167 1.93 1 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 14.09 1 No Yes 4 5 1 1
S:S:S417 S:S:W70 2.47 1 Yes Yes 6 5 1 1
K:K:?6 S:S:W70 9.17 1 Yes Yes 0 5 0 1
S:S:A73 S:S:F330 4.16 0 No Yes 7 8 2 2
S:S:A73 S:S:S417 1.71 0 No Yes 7 6 2 1
S:S:T145 S:S:Y167 3.75 1 Yes Yes 5 8 2 2
S:S:F330 S:S:L334 12.18 1 Yes Yes 8 6 2 2
S:S:F330 S:S:L414 3.65 1 Yes Yes 8 6 2 2
S:S:L334 S:S:Y411 3.52 1 Yes Yes 6 5 2 2
S:S:L414 S:S:Y411 4.69 1 Yes Yes 6 5 2 2
S:S:L414 S:S:S417 6.01 1 Yes Yes 6 6 2 1
K:K:?6 S:S:I416 6.57 1 Yes No 0 4 0 1
K:K:?6 S:S:S417 6.91 1 Yes Yes 0 6 0 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.84
Average Nodes In Shell15.00
Average Hubs In Shell12.00
Average Links In Shell26.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8SZI C Ion Calcium-sensing CaS Homo sapiens - Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW Gi3/Beta1/Gamma2 3.5 2024-02-07 10.1038/s41586-024-07055-2

A 2D representation of the interactions of PO4 in 8SZI
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F38 R:R:W70 2 2 Yes Yes 7 5 2 1
R:R:F38 R:R:Y167 10.32 2 Yes Yes 7 8 2 2
R:R:R66 R:R:R69 5.33 2 Yes Yes 5 8 1 1
R:R:R66 R:R:W70 9 2 Yes Yes 5 5 1 1
R:R:R66 W:W:W4 3 2 Yes Yes 5 0 1 2
R:R:R66 W:W:?5 13.97 2 Yes Yes 5 0 1 0
R:R:F330 R:R:R69 2.14 2 Yes Yes 8 8 2 1
R:R:L334 R:R:R69 3.64 2 Yes Yes 6 8 2 1
R:R:R69 R:R:Y411 10.29 2 Yes Yes 8 5 1 2
R:R:R69 R:R:S417 2.64 2 Yes Yes 8 6 1 1
R:R:R69 W:W:?5 11.18 2 Yes Yes 8 0 1 0
R:R:T145 R:R:W70 2.43 2 Yes Yes 5 5 2 1
R:R:W70 R:R:Y167 2.89 2 Yes Yes 5 8 1 2
R:R:I416 R:R:W70 19.97 2 No Yes 4 5 1 1
R:R:S417 R:R:W70 3.71 2 Yes Yes 6 5 1 1
R:R:W70 W:W:?5 10.48 2 Yes Yes 5 0 1 0
R:R:T145 R:R:Y167 3.75 2 Yes Yes 5 8 2 2
R:R:T145 W:W:W4 6.06 2 Yes Yes 5 0 2 2
R:R:I416 R:R:Y167 2.42 2 No Yes 4 8 1 2
R:R:A321 R:R:R415 5.53 0 No Yes 5 5 2 1
R:R:L322 R:R:R415 2.43 0 No Yes 4 5 2 1
R:R:F330 R:R:L334 13.4 2 Yes Yes 8 6 2 2
R:R:F330 R:R:L414 3.65 2 Yes Yes 8 6 2 2
R:R:F330 R:R:S417 2.64 2 Yes Yes 8 6 2 1
R:R:L334 R:R:Y411 2.34 2 Yes Yes 6 5 2 2
R:R:L414 R:R:Y411 5.86 2 Yes Yes 6 5 2 2
R:R:H413 R:R:R415 11.28 0 No Yes 7 5 2 1
R:R:L414 R:R:S417 3 2 Yes Yes 6 6 2 1
R:R:R415 W:W:?5 2.79 0 Yes Yes 5 0 1 0
R:R:I416 W:W:?5 8.21 2 No Yes 4 0 1 0
R:R:S417 W:W:?5 5.18 2 Yes Yes 6 0 1 0
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.63
Average Nodes In Shell18.00
Average Hubs In Shell14.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PO4 in 8SZI
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F38 S:S:W70 2 1 Yes Yes 7 5 2 1
S:S:F38 S:S:Y167 10.32 1 Yes Yes 7 8 2 2
S:S:R66 S:S:R69 5.33 1 Yes Yes 5 8 1 1
S:S:R66 S:S:W70 9 1 Yes Yes 5 5 1 1
K:K:W4 S:S:R66 6 1 Yes Yes 0 5 2 1
K:K:?5 S:S:R66 15.37 1 Yes Yes 0 5 0 1
S:S:R69 S:S:W70 2 1 Yes Yes 8 5 1 1
S:S:L334 S:S:R69 3.64 1 Yes Yes 6 8 2 1
S:S:R69 S:S:Y408 2.06 1 Yes Yes 8 3 1 2
S:S:R69 S:S:Y411 6.17 1 Yes Yes 8 5 1 2
K:K:?5 S:S:R69 13.97 1 Yes Yes 0 8 0 1
S:S:T145 S:S:W70 3.64 1 Yes Yes 5 5 2 1
S:S:W70 S:S:Y167 6.75 1 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 14.09 1 No Yes 4 5 1 1
S:S:S417 S:S:W70 2.47 1 No Yes 6 5 1 1
K:K:W4 S:S:W70 1.87 1 Yes Yes 0 5 2 1
K:K:?5 S:S:W70 6.55 1 Yes Yes 0 5 0 1
S:S:T145 S:S:Y167 3.75 1 Yes Yes 5 8 2 2
K:K:W4 S:S:T145 6.06 1 Yes Yes 0 5 2 2
S:S:I416 S:S:Y167 2.42 1 No Yes 4 8 1 2
S:S:A321 S:S:R415 6.91 0 No Yes 5 5 2 1
S:S:A324 S:S:H413 4.39 1 No No 5 7 2 2
S:S:A324 S:S:R415 2.77 1 No Yes 5 5 2 1
S:S:L334 S:S:Y408 7.03 1 Yes Yes 6 3 2 2
S:S:L334 S:S:Y411 2.34 1 Yes Yes 6 5 2 2
S:S:L414 S:S:Y411 7.03 1 Yes Yes 6 5 2 2
S:S:H413 S:S:R415 11.28 1 No Yes 7 5 2 1
S:S:L414 S:S:S417 7.51 1 Yes No 6 6 2 1
K:K:?5 S:S:R415 4.19 1 Yes Yes 0 5 0 1
K:K:?5 S:S:I416 6.57 1 Yes No 0 4 0 1
K:K:?5 S:S:S417 6.91 1 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.93
Average Nodes In Shell18.00
Average Hubs In Shell13.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WPG C Ion Calcium-sensing CaS Homo sapiens - Tryptophan; Cinacalcet; PO4; Ca - 2.7 2023-11-22 10.1038/s41422-023-00892-2

A 2D representation of the interactions of PO4 in 8WPG
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:P39 S:S:W70 5.4 1 No Yes 6 5 2 1
S:S:P39 S:S:T145 10.49 1 No Yes 6 5 2 2
S:S:R66 S:S:R69 6.4 1 Yes Yes 5 8 1 1
S:S:R66 S:S:W70 8 1 Yes Yes 5 5 1 1
S:S:R66 X:X:W1 4 1 Yes Yes 5 0 1 2
S:S:R66 X:X:?5 20.96 1 Yes Yes 5 0 1 0
S:S:G67 S:S:W70 5.63 0 No Yes 4 5 2 1
S:S:L334 S:S:R69 4.86 1 Yes Yes 6 8 2 1
S:S:R69 S:S:Y411 12.35 1 Yes Yes 8 5 1 2
S:S:R69 S:S:S417 3.95 1 Yes Yes 8 6 1 1
S:S:R69 X:X:?5 13.97 1 Yes Yes 8 0 1 0
S:S:T145 S:S:W70 7.28 1 Yes Yes 5 5 2 1
S:S:W70 S:S:Y167 6.75 1 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 15.27 1 Yes Yes 4 5 1 1
S:S:S417 S:S:W70 4.94 1 Yes Yes 6 5 1 1
S:S:W70 X:X:W1 5.62 1 Yes Yes 5 0 1 2
S:S:W70 X:X:?5 10.48 1 Yes Yes 5 0 1 0
S:S:T145 S:S:Y167 7.49 1 Yes Yes 5 8 2 2
S:S:T145 X:X:W1 6.06 1 Yes Yes 5 0 2 2
S:S:I416 S:S:Y167 4.84 1 Yes Yes 4 8 1 2
S:S:E297 S:S:I416 4.1 1 Yes Yes 8 4 2 1
S:S:E297 X:X:W1 5.45 1 Yes Yes 8 0 2 2
S:S:A321 S:S:R415 6.91 0 No No 5 5 2 1
S:S:L334 S:S:Y411 3.52 1 Yes Yes 6 5 2 2
S:S:L414 S:S:Y411 16.41 1 Yes Yes 6 5 2 2
S:S:H413 S:S:R415 13.54 0 No No 7 5 2 1
S:S:L414 S:S:S417 6.01 1 Yes Yes 6 6 2 1
S:S:R415 X:X:?5 5.59 0 No Yes 5 0 1 0
S:S:I416 X:X:W1 3.52 1 Yes Yes 4 0 1 2
S:S:I416 X:X:?5 8.21 1 Yes Yes 4 0 1 0
S:S:S417 X:X:?5 5.18 1 Yes Yes 6 0 1 0
S:S:R66 S:S:S301 2.64 1 Yes No 5 5 1 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength10.73
Average Nodes In Shell19.00
Average Hubs In Shell13.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PO4 in 8WPG
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P39 R:R:W70 5.4 2 No Yes 6 5 2 1
R:R:P39 R:R:T145 8.74 2 No Yes 6 5 2 2
R:R:R66 R:R:R69 5.33 2 Yes Yes 5 8 1 1
R:R:R66 R:R:W70 8 2 Yes Yes 5 5 1 1
R:R:R66 W:W:W1 5 2 Yes Yes 5 0 1 2
R:R:R66 W:W:?3 23.75 2 Yes Yes 5 0 1 0
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:L334 R:R:R69 4.86 2 Yes Yes 6 8 2 1
R:R:R69 R:R:Y411 13.38 2 Yes Yes 8 5 1 2
R:R:R69 R:R:S417 3.95 2 Yes Yes 8 6 1 1
R:R:R69 W:W:?3 13.97 2 Yes Yes 8 0 1 0
R:R:T145 R:R:W70 7.28 2 Yes Yes 5 5 2 1
R:R:W70 R:R:Y167 6.75 2 Yes Yes 5 8 1 2
R:R:I416 R:R:W70 17.62 2 Yes Yes 4 5 1 1
R:R:S417 R:R:W70 3.71 2 Yes Yes 6 5 1 1
R:R:W70 W:W:W1 6.56 2 Yes Yes 5 0 1 2
R:R:W70 W:W:?3 10.48 2 Yes Yes 5 0 1 0
R:R:T145 R:R:Y167 6.24 2 Yes Yes 5 8 2 2
R:R:T145 W:W:W1 6.06 2 Yes Yes 5 0 2 2
R:R:I416 R:R:Y167 4.84 2 Yes Yes 4 8 1 2
R:R:A321 R:R:R415 6.91 0 No No 5 5 2 1
R:R:L334 R:R:Y411 3.52 2 Yes Yes 6 5 2 2
R:R:L414 R:R:Y411 12.89 2 Yes Yes 6 5 2 2
R:R:H413 R:R:R415 14.67 0 No No 7 5 2 1
R:R:L414 R:R:S417 6.01 2 Yes Yes 6 6 2 1
R:R:R415 W:W:?3 6.99 0 No Yes 5 0 1 0
R:R:I416 W:W:W1 3.52 2 Yes Yes 4 0 1 2
R:R:I416 W:W:?3 9.85 2 Yes Yes 4 0 1 0
R:R:S417 W:W:?3 6.91 2 Yes Yes 6 0 1 0
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength11.99
Average Nodes In Shell17.00
Average Hubs In Shell12.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WPU C Ion Calcium-sensing CaS Homo sapiens - Tryptophan; Cinacalcet; PO4; Ca chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 3.1 2023-11-22 10.1038/s41422-023-00892-2

A 2D representation of the interactions of PO4 in 8WPU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F38 S:S:W70 3.01 2 Yes Yes 7 5 2 1
S:S:F38 S:S:Y167 12.38 2 Yes Yes 7 8 2 2
S:S:F38 S:S:V420 3.93 2 Yes Yes 7 7 2 2
S:S:G67 S:S:P39 2.03 2 No Yes 4 6 2 2
S:S:P39 S:S:W70 5.4 2 Yes Yes 6 5 2 1
S:S:P39 S:S:T145 8.74 2 Yes Yes 6 5 2 2
S:S:N64 S:S:R66 6.03 0 No Yes 4 5 2 1
S:S:G67 S:S:N64 3.39 2 No No 4 4 2 2
S:S:R66 S:S:R69 3.2 2 Yes Yes 5 8 1 1
S:S:R66 S:S:W70 8 2 Yes Yes 5 5 1 1
S:S:P407 S:S:R66 2.88 2 Yes Yes 1 5 2 1
S:S:R66 X:X:W1 3 2 Yes Yes 5 0 1 2
S:S:R66 X:X:?2 18.17 2 Yes Yes 5 0 1 0
S:S:G67 S:S:W70 5.63 2 No Yes 4 5 2 1
S:S:R69 S:S:Y408 3.09 2 Yes Yes 8 3 1 2
S:S:R69 S:S:Y411 17.49 2 Yes Yes 8 5 1 2
S:S:R69 X:X:?2 5.59 2 Yes Yes 8 0 1 0
S:S:T145 S:S:W70 7.28 2 Yes Yes 5 5 2 1
S:S:W70 S:S:Y167 5.79 2 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 12.92 2 Yes Yes 4 5 1 1
S:S:S417 S:S:W70 6.18 2 No Yes 6 5 1 1
S:S:V420 S:S:W70 2.45 2 Yes Yes 7 5 2 1
S:S:W70 X:X:W1 2.81 2 Yes Yes 5 0 1 2
S:S:W70 X:X:?2 9.17 2 Yes Yes 5 0 1 0
S:S:T145 S:S:Y167 6.24 2 Yes Yes 5 8 2 2
S:S:T145 X:X:W1 4.85 2 Yes Yes 5 0 2 2
S:S:I416 S:S:Y167 4.84 2 Yes Yes 4 8 1 2
S:S:V420 S:S:Y167 10.09 2 Yes Yes 7 8 2 2
S:S:A321 S:S:R415 6.91 0 Yes No 5 5 2 1
S:S:L414 S:S:Y411 8.21 2 Yes Yes 6 5 2 2
S:S:H413 S:S:R415 13.54 0 No No 7 5 2 1
S:S:L414 S:S:S417 4.5 2 Yes No 6 6 2 1
S:S:R415 X:X:?2 6.99 0 No Yes 5 0 1 0
S:S:I416 S:S:N419 2.83 2 Yes No 4 7 1 2
S:S:I416 X:X:?2 6.57 2 Yes Yes 4 0 1 0
S:S:S417 X:X:?2 5.18 2 No Yes 6 0 1 0
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.61
Average Nodes In Shell22.00
Average Hubs In Shell16.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PO4 in 8WPU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F38 R:R:W70 2 1 Yes Yes 7 5 2 1
R:R:F38 R:R:Y167 13.41 1 Yes Yes 7 8 2 2
R:R:F38 R:R:V420 5.24 1 Yes Yes 7 7 2 2
R:R:N64 R:R:P39 3.26 1 Yes Yes 4 6 2 2
R:R:G67 R:R:P39 2.03 1 No Yes 4 6 2 2
R:R:P39 R:R:W70 5.4 1 Yes Yes 6 5 2 1
R:R:P39 R:R:T145 8.74 1 Yes Yes 6 5 2 2
R:R:N64 R:R:R66 3.62 1 Yes Yes 4 5 2 1
R:R:G67 R:R:N64 5.09 1 No Yes 4 4 2 2
R:R:R66 R:R:R69 5.33 1 Yes Yes 5 8 1 1
R:R:R66 R:R:W70 7 1 Yes Yes 5 5 1 1
R:R:R66 W:W:W1 4 1 Yes Yes 5 0 1 2
R:R:R66 W:W:?2 26.55 1 Yes Yes 5 0 1 0
R:R:G67 R:R:W70 5.63 1 No Yes 4 5 2 1
R:R:F330 R:R:R69 2.14 1 Yes Yes 8 8 2 1
R:R:L334 R:R:R69 4.86 1 Yes Yes 6 8 2 1
R:R:R69 R:R:Y408 2.06 1 Yes Yes 8 3 1 2
R:R:R69 R:R:Y411 11.32 1 Yes Yes 8 5 1 2
R:R:L414 R:R:R69 2.43 1 Yes Yes 6 8 2 1
R:R:R69 R:R:S417 6.59 1 Yes Yes 8 6 1 1
R:R:R69 W:W:?2 16.77 1 Yes Yes 8 0 1 0
R:R:T145 R:R:W70 7.28 1 Yes Yes 5 5 2 1
R:R:W70 R:R:Y167 3.86 1 Yes Yes 5 8 1 2
R:R:I416 R:R:W70 12.92 1 Yes Yes 4 5 1 1
R:R:S417 R:R:W70 3.71 1 Yes Yes 6 5 1 1
R:R:V420 R:R:W70 2.45 1 Yes Yes 7 5 2 1
R:R:W70 W:W:W1 4.69 1 Yes Yes 5 0 1 2
R:R:W70 W:W:?2 14.41 1 Yes Yes 5 0 1 0
R:R:T145 R:R:Y167 7.49 1 Yes Yes 5 8 2 2
R:R:T145 W:W:W1 6.06 1 Yes Yes 5 0 2 2
R:R:I416 R:R:Y167 4.84 1 Yes Yes 4 8 1 2
R:R:V420 R:R:Y167 8.83 1 Yes Yes 7 8 2 2
R:R:A321 R:R:R415 6.91 0 No No 5 5 2 1
R:R:F330 R:R:L334 15.83 1 Yes Yes 8 6 2 2
R:R:F330 R:R:L414 6.09 1 Yes Yes 8 6 2 2
R:R:F330 R:R:S417 2.64 1 Yes Yes 8 6 2 1
R:R:L334 R:R:Y408 11.72 1 Yes Yes 6 3 2 2
R:R:L334 R:R:Y411 3.52 1 Yes Yes 6 5 2 2
R:R:L414 R:R:Y411 11.72 1 Yes Yes 6 5 2 2
R:R:H413 R:R:R415 12.41 0 No No 7 5 2 1
R:R:L414 R:R:S417 6.01 1 Yes Yes 6 6 2 1
R:R:R415 W:W:?2 2.79 0 No Yes 5 0 1 0
R:R:I416 R:R:N419 2.83 1 Yes Yes 4 7 1 2
R:R:I416 W:W:W1 5.87 1 Yes Yes 4 0 1 2
R:R:I416 W:W:?2 9.85 1 Yes Yes 4 0 1 0
R:R:S417 W:W:?2 5.18 1 Yes Yes 6 0 1 0
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength12.59
Average Nodes In Shell23.00
Average Hubs In Shell19.00
Average Links In Shell46.00
Average Links Mediated by Hubs In Shell44.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9AXF C Ion Calcium-sensing CaS Homo Sapiens Ca Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 3.5 2024-04-17 10.1038/s41586-024-07331-1

A 2D representation of the interactions of PO4 in 9AXF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F38 R:R:W70 2 1 Yes Yes 7 5 2 1
R:R:F38 R:R:Y167 11.35 1 Yes Yes 7 8 2 2
R:R:N64 R:R:P39 1.63 0 Yes Yes 4 6 2 2
R:R:P39 R:R:W70 4.05 1 Yes Yes 6 5 2 1
R:R:P39 R:R:T145 6.99 1 Yes Yes 6 5 2 2
R:R:N64 R:R:R66 3.62 0 Yes Yes 4 5 2 1
R:R:G67 R:R:N64 3.39 0 No Yes 4 4 2 2
R:R:R66 R:R:R69 4.26 1 Yes Yes 5 8 1 1
R:R:R66 R:R:W70 12 1 Yes Yes 5 5 1 1
R:R:R66 W:W:?1 5.96 1 Yes Yes 5 0 1 2
R:R:R66 W:W:?2 13.97 1 Yes Yes 5 0 1 0
L:L:?1 R:R:R66 4.46 0 No Yes 0 5 2 1
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:F330 R:R:R69 3.21 1 Yes Yes 8 8 2 1
R:R:L334 R:R:R69 2.43 1 Yes Yes 6 8 2 1
R:R:R69 R:R:Y411 13.38 1 Yes Yes 8 5 1 2
R:R:R69 R:R:S417 2.64 1 Yes Yes 8 6 1 1
R:R:R69 W:W:?2 13.97 1 Yes Yes 8 0 1 0
R:R:T145 R:R:W70 3.64 1 Yes Yes 5 5 2 1
R:R:W70 R:R:Y167 1.93 1 Yes Yes 5 8 1 2
R:R:I416 R:R:W70 21.14 1 Yes Yes 4 5 1 1
R:R:S417 R:R:W70 4.94 1 Yes Yes 6 5 1 1
R:R:W70 W:W:?1 3.19 1 Yes Yes 5 0 1 2
R:R:W70 W:W:?2 7.86 1 Yes Yes 5 0 1 0
R:R:A73 R:R:F330 4.16 0 No Yes 7 8 2 2
R:R:A73 R:R:S417 1.71 0 No Yes 7 6 2 1
R:R:T145 R:R:Y167 6.24 1 Yes Yes 5 8 2 2
R:R:A168 R:R:T145 3.36 1 Yes Yes 5 5 2 2
R:R:T145 W:W:?1 5.17 1 Yes Yes 5 0 2 2
R:R:A168 R:R:Y167 2.67 1 Yes Yes 5 8 2 2
R:R:A168 R:R:I416 1.62 1 Yes Yes 5 4 2 1
R:R:A168 W:W:?1 3.31 1 Yes Yes 5 0 2 2
R:R:A321 R:R:R415 6.91 0 No Yes 5 5 2 1
R:R:L322 R:R:R415 2.43 1 Yes Yes 4 5 2 1
R:R:A324 R:R:H413 4.39 1 No No 5 7 2 2
R:R:A324 R:R:R415 2.77 1 No Yes 5 5 2 1
R:R:F330 R:R:I327 6.28 1 Yes Yes 8 6 2 2
R:R:I327 R:R:L414 4.28 1 Yes Yes 6 6 2 1
R:R:F330 R:R:L334 13.4 1 Yes Yes 8 6 2 2
R:R:F330 R:R:L414 4.87 1 Yes Yes 8 6 2 1
R:R:L334 R:R:Y411 2.34 1 Yes Yes 6 5 2 2
R:R:L414 R:R:Y411 11.72 1 Yes Yes 6 5 1 2
R:R:H413 R:R:R415 15.8 1 No Yes 7 5 2 1
R:R:L414 R:R:S417 4.5 1 Yes Yes 6 6 1 1
R:R:L414 W:W:?2 4.78 1 Yes Yes 6 0 1 0
R:R:R415 W:W:?2 4.19 1 Yes Yes 5 0 1 0
R:R:I416 W:W:?1 2 1 Yes Yes 4 0 1 2
R:R:I416 W:W:?2 8.21 1 Yes Yes 4 0 1 0
R:R:S417 W:W:?2 8.64 1 Yes Yes 6 0 1 0
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.80
Average Nodes In Shell26.00
Average Hubs In Shell20.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell48.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PO4 in 9AXF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F38 S:S:W70 2 1 Yes Yes 7 5 2 1
S:S:F38 S:S:Y167 12.38 1 Yes Yes 7 8 2 2
S:S:N64 S:S:P39 3.26 0 Yes Yes 4 6 2 2
S:S:P39 S:S:W70 4.05 1 Yes Yes 6 5 2 1
S:S:P39 S:S:T145 6.99 1 Yes Yes 6 5 2 2
S:S:N64 S:S:R66 2.41 0 Yes Yes 4 5 2 1
S:S:G67 S:S:N64 3.39 0 No Yes 4 4 2 2
S:S:R66 S:S:R69 5.33 1 Yes Yes 5 8 1 1
S:S:R66 S:S:W70 10 1 Yes Yes 5 5 1 1
S:S:R66 S:S:S301 2.64 1 Yes No 5 5 1 2
S:S:R66 X:X:?1 4.26 1 Yes Yes 5 0 1 2
S:S:R66 X:X:?2 20.96 1 Yes Yes 5 0 1 0
S:S:G67 S:S:W70 5.63 0 No Yes 4 5 2 1
S:S:F330 S:S:R69 3.21 1 Yes Yes 8 8 2 1
S:S:L334 S:S:R69 2.43 1 Yes Yes 6 8 2 1
S:S:R69 S:S:Y411 10.29 1 Yes Yes 8 5 1 2
S:S:R69 S:S:S417 2.64 1 Yes Yes 8 6 1 1
S:S:R69 X:X:?2 9.78 1 Yes Yes 8 0 1 0
S:S:T145 S:S:W70 3.64 1 Yes Yes 5 5 2 1
S:S:W70 S:S:Y167 1.93 1 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 18.79 1 Yes Yes 4 5 1 1
S:S:S417 S:S:W70 3.71 1 Yes Yes 6 5 1 1
S:S:W70 X:X:?1 3.19 1 Yes Yes 5 0 1 2
S:S:W70 X:X:?2 9.17 1 Yes Yes 5 0 1 0
S:S:A73 S:S:F330 4.16 0 No Yes 7 8 2 2
S:S:A73 S:S:S417 1.71 0 No Yes 7 6 2 1
S:S:T145 S:S:Y167 7.49 1 Yes Yes 5 8 2 2
S:S:A168 S:S:T145 3.36 1 Yes Yes 5 5 2 2
S:S:T145 X:X:?1 5.17 1 Yes Yes 5 0 2 2
S:S:A168 S:S:Y167 2.67 1 Yes Yes 5 8 2 2
S:S:I416 S:S:Y167 2.42 1 Yes Yes 4 8 1 2
S:S:A168 S:S:I416 3.25 1 Yes Yes 5 4 2 1
S:S:A168 X:X:?1 2.21 1 Yes Yes 5 0 2 2
S:S:A321 S:S:R415 6.91 0 No Yes 5 5 2 1
S:S:A324 S:S:H413 4.39 1 Yes No 5 7 2 2
S:S:A324 S:S:R415 2.77 1 Yes Yes 5 5 2 1
S:S:F330 S:S:I327 7.54 1 Yes Yes 8 6 2 2
S:S:I327 S:S:L414 4.28 1 Yes Yes 6 6 2 1
S:S:I327 S:S:S417 1.55 1 Yes Yes 6 6 2 1
S:S:F330 S:S:L334 14.61 1 Yes Yes 8 6 2 2
S:S:F330 S:S:L414 3.65 1 Yes Yes 8 6 2 1
S:S:L334 S:S:Y411 3.52 1 Yes Yes 6 5 2 2
S:S:L414 S:S:Y411 11.72 1 Yes Yes 6 5 1 2
S:S:H413 S:S:R415 13.54 1 No Yes 7 5 2 1
S:S:L414 S:S:S417 7.51 1 Yes Yes 6 6 1 1
S:S:L414 X:X:?2 1.59 1 Yes Yes 6 0 1 0
S:S:R415 X:X:?2 4.19 1 Yes Yes 5 0 1 0
S:S:I416 X:X:?1 3 1 Yes Yes 4 0 1 2
S:S:I416 X:X:?2 11.49 1 Yes Yes 4 0 1 0
S:S:S417 X:X:?2 8.64 1 Yes Yes 6 0 1 0
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub7.00
Average Interaction Strength9.40
Average Nodes In Shell25.00
Average Hubs In Shell20.00
Average Links In Shell50.00
Average Links Mediated by Hubs In Shell50.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9AYF C Ion Calcium-sensing CaS Homo Sapiens Ca Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 Gi1/Beta1/Gamma2 3.6 2024-04-17 10.1038/s41586-024-07331-1

A 2D representation of the interactions of PO4 in 9AYF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F38 S:S:W70 2 1 Yes Yes 7 5 2 1
S:S:F38 S:S:Y167 9.28 1 Yes Yes 7 8 2 2
S:S:G67 S:S:P39 2.03 1 No Yes 4 6 2 2
S:S:P39 S:S:W70 4.05 1 Yes Yes 6 5 2 1
S:S:P39 S:S:T145 5.25 1 Yes Yes 6 5 2 2
S:S:N64 S:S:R66 3.62 0 No Yes 4 5 2 1
S:S:G67 S:S:N64 1.7 1 No No 4 4 2 2
S:S:R66 S:S:R69 5.33 1 Yes Yes 5 8 1 1
S:S:R66 S:S:W70 10 1 Yes Yes 5 5 1 1
S:S:R66 X:X:?1 5.11 1 Yes Yes 5 0 1 2
S:S:R66 X:X:?2 22.36 1 Yes Yes 5 0 1 0
M:M:?7 S:S:R66 4.46 0 Yes Yes 0 5 2 1
S:S:G67 S:S:W70 5.63 1 No Yes 4 5 2 1
S:S:F330 S:S:R69 3.21 1 Yes Yes 8 8 2 1
S:S:L334 S:S:R69 2.43 1 Yes Yes 6 8 2 1
S:S:R69 S:S:Y411 10.29 1 Yes No 8 5 1 2
S:S:R69 S:S:S417 2.64 1 Yes Yes 8 6 1 1
S:S:R69 X:X:?2 13.97 1 Yes Yes 8 0 1 0
S:S:T145 S:S:W70 3.64 1 Yes Yes 5 5 2 1
S:S:W70 S:S:Y167 4.82 1 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 16.44 1 Yes Yes 4 5 1 1
S:S:S417 S:S:W70 4.94 1 Yes Yes 6 5 1 1
S:S:W70 X:X:?1 2.4 1 Yes Yes 5 0 1 2
S:S:W70 X:X:?2 7.86 1 Yes Yes 5 0 1 0
S:S:A73 S:S:F330 2.77 0 No Yes 7 8 2 2
S:S:A73 S:S:S417 1.71 0 No Yes 7 6 2 1
S:S:T145 S:S:Y167 4.99 1 Yes Yes 5 8 2 2
S:S:A168 S:S:T145 3.36 1 No Yes 5 5 2 2
S:S:T145 X:X:?1 3.1 1 Yes Yes 5 0 2 2
S:S:A168 S:S:Y167 2.67 1 No Yes 5 8 2 2
S:S:A168 S:S:I416 1.62 1 No Yes 5 4 2 1
S:S:E297 S:S:L322 10.6 1 Yes Yes 8 4 2 2
S:S:E297 S:S:I416 4.1 1 Yes Yes 8 4 2 1
S:S:E297 X:X:?1 7.43 1 Yes Yes 8 0 2 2
S:S:A321 S:S:R415 5.53 0 No Yes 5 5 2 1
S:S:L322 S:S:R415 2.43 1 Yes Yes 4 5 2 1
S:S:F330 S:S:I327 2.51 1 Yes Yes 8 6 2 2
S:S:I327 S:S:L414 2.85 1 Yes Yes 6 6 2 1
S:S:F330 S:S:L334 12.18 1 Yes Yes 8 6 2 2
S:S:F330 S:S:L414 3.65 1 Yes Yes 8 6 2 1
S:S:L414 S:S:Y411 16.41 1 Yes No 6 5 1 2
S:S:H413 S:S:R415 12.41 0 No Yes 7 5 2 1
S:S:L414 S:S:S417 4.5 1 Yes Yes 6 6 1 1
S:S:L414 X:X:?2 3.18 1 Yes Yes 6 0 1 0
S:S:R415 X:X:?2 2.79 0 Yes Yes 5 0 1 0
S:S:I416 S:S:N419 2.83 1 Yes No 4 7 1 2
S:S:I416 X:X:?1 3 1 Yes Yes 4 0 1 2
S:S:I416 X:X:?2 11.49 1 Yes Yes 4 0 1 0
S:S:S417 X:X:?2 6.91 1 Yes Yes 6 0 1 0
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub7.00
Average Interaction Strength9.79
Average Nodes In Shell27.00
Average Hubs In Shell19.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell48.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PO4 in 9AYF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F38 R:R:W70 2 1 Yes Yes 7 5 2 1
R:R:F38 R:R:Y167 12.38 1 Yes Yes 7 8 2 2
R:R:N64 R:R:P39 3.26 0 Yes Yes 4 6 2 2
R:R:P39 R:R:W70 4.05 1 Yes Yes 6 5 2 1
R:R:P39 R:R:T145 6.99 1 Yes Yes 6 5 2 2
R:R:N64 R:R:R66 3.62 0 Yes Yes 4 5 2 1
R:R:G67 R:R:N64 1.7 0 No Yes 4 4 2 2
R:R:R66 R:R:R69 4.26 1 Yes Yes 5 8 1 1
R:R:R66 R:R:W70 13 1 Yes Yes 5 5 1 1
R:R:R66 W:W:?1 5.11 1 Yes Yes 5 0 1 2
R:R:R66 W:W:?2 20.96 1 Yes Yes 5 0 1 0
L:L:?3 R:R:R66 2.23 1 No Yes 0 5 2 1
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:F330 R:R:R69 3.21 1 Yes Yes 8 8 2 1
R:R:L334 R:R:R69 3.64 1 Yes Yes 6 8 2 1
R:R:R69 R:R:Y411 7.2 1 Yes Yes 8 5 1 2
R:R:L414 R:R:R69 2.43 1 Yes Yes 6 8 1 1
R:R:R69 R:R:S417 3.95 1 Yes Yes 8 6 1 1
R:R:R69 W:W:?2 11.18 1 Yes Yes 8 0 1 0
R:R:T145 R:R:W70 3.64 1 Yes Yes 5 5 2 1
R:R:W70 R:R:Y167 4.82 1 Yes Yes 5 8 1 2
R:R:I416 R:R:W70 14.09 1 Yes Yes 4 5 1 1
R:R:S417 R:R:W70 3.71 1 Yes Yes 6 5 1 1
R:R:W70 W:W:?1 2.4 1 Yes Yes 5 0 1 2
R:R:W70 W:W:?2 7.86 1 Yes Yes 5 0 1 0
R:R:A73 R:R:F330 4.16 0 No Yes 7 8 2 2
R:R:A73 R:R:S417 1.71 0 No Yes 7 6 2 1
R:R:T145 R:R:Y167 4.99 1 Yes Yes 5 8 2 2
R:R:A168 R:R:T145 3.36 1 Yes Yes 5 5 2 2
R:R:T145 W:W:?1 5.17 1 Yes Yes 5 0 2 2
R:R:A168 R:R:Y167 2.67 1 Yes Yes 5 8 2 2
R:R:I416 R:R:Y167 4.84 1 Yes Yes 4 8 1 2
R:R:A168 R:R:I416 1.62 1 Yes Yes 5 4 2 1
R:R:A168 W:W:?1 2.21 1 Yes Yes 5 0 2 2
R:R:A321 R:R:R415 5.53 0 No Yes 5 5 2 1
R:R:L322 R:R:R415 2.43 1 Yes Yes 4 5 2 1
R:R:F330 R:R:I327 5.02 1 Yes Yes 8 6 2 2
R:R:I327 R:R:L414 2.85 1 Yes Yes 6 6 2 1
R:R:F330 R:R:L334 13.4 1 Yes Yes 8 6 2 2
R:R:F330 R:R:L414 2.44 1 Yes Yes 8 6 2 1
R:R:L334 R:R:Y411 3.52 1 Yes Yes 6 5 2 2
R:R:L414 R:R:Y411 8.21 1 Yes Yes 6 5 1 2
R:R:H413 R:R:R415 13.54 0 No Yes 7 5 2 1
R:R:L414 R:R:S417 4.5 1 Yes Yes 6 6 1 1
R:R:L414 W:W:?2 3.18 1 Yes Yes 6 0 1 0
R:R:R415 W:W:?2 4.19 0 Yes Yes 5 0 1 0
R:R:I416 W:W:?2 11.49 1 Yes Yes 4 0 1 0
R:R:S417 W:W:?2 6.91 1 Yes Yes 6 0 1 0
L:L:?3 W:W:?1 1.78 1 No Yes 0 0 2 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub7.00
Average Interaction Strength9.40
Average Nodes In Shell25.00
Average Hubs In Shell20.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell49.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links6.28
Average Number Of Links With An Hub5.28
Average Interaction Strength9.29
Average Nodes In Shell20.44
Average Hubs In Shell14.80
Average Links In Shell35.20
Average Links Mediated by Hubs In Shell34.12

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)