Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L39 3.658509
2A:A:I184 7.8275459
3A:A:E186 4.2575459
4A:A:F196 6.364417
5A:A:F199 7.38455
6A:A:V201 4.405459
7A:A:Q204 3.766559
8A:A:K210 4.64659
9A:A:W211 4.62333659
10A:A:H213 6.05754198
11A:A:F215 5.41559
12A:A:F223 3.7125409
13A:A:V225 2.7875407
14A:A:Y230 7.2156288
15A:A:D231 7.1154289
16A:A:W258 7.875195
17A:A:F259 6.5754429
18A:A:F274 6.8465289
19A:A:S281 5.58254287
20A:A:L283 6.655407
21A:A:Y287 4.568507
22A:A:Y296 4.512504
23A:A:Q304 7.864465
24A:A:F307 8.2975408
25A:A:E308 7.22254463
26A:A:Y320 6.1365247
27A:A:T324 5.384439
28A:A:D328 4.46254439
29A:A:F336 5.5325408
30A:A:D337 4.17404
31A:A:K345 6.68254245
32A:A:L348 4.8554139
33B:B:T34 5.98254255
34B:B:V40 2.7475403
35B:B:L51 8.175409
36B:B:H54 8.875409
37B:B:Y59 6.9925198
38B:B:M61 3.485486
39B:B:W63 6.24167687
40B:B:L70 6.1975485
41B:B:L79 4.42754337
42B:B:W82 10.014589
43B:B:S84 3.865485
44B:B:N88 2.9675407
45B:B:K89 6.83589
46B:B:I93 4.7175407
47B:B:L95 3.944338
48B:B:W99 8.316559
49B:B:I120 2.575406
50B:B:I123 3.8175406
51B:B:Y124 4.796336
52B:B:L139 5.7325409
53B:B:H142 6.435209
54B:B:Y145 4.17125858
55B:B:C149 2.7825208
56B:B:L152 3.545403
57B:B:T159 5.81254209
58B:B:W169 9.8025208
59B:B:D170 4.1675469
60B:B:F180 6.79567
61B:B:H183 6.254569
62B:B:D186 4.006559
63B:B:V187 4.3775469
64B:B:F199 6.328569
65B:B:V200 4.9025496
66B:B:C204 4.745457
67B:B:D205 4.87569
68B:B:K209 6.18566
69B:B:L210 4.836505
70B:B:W211 9.18568
71B:B:M217 4.01254343
72B:B:Q220 6.4075497
73B:B:F222 6.435498
74B:B:H225 8.98599
75B:B:I232 4.698598
76B:B:F235 7.896676116
77B:B:P236 5.32254117
78B:B:F241 5.38167696
79B:B:T243 5.03167698
80B:B:T249 4.6225496
81B:B:R251 8.946598
82B:B:F253 6.036596
83B:B:D258 8.5125497
84B:B:E260 6.0625496
85B:B:Y264 4.186115
86B:B:C271 4.60754115
87B:B:F278 3.966117
88B:B:R283 7.23254259
89B:B:Y289 5.824297117
90B:B:W297 3.935118
91B:B:D298 6.98754259
92B:B:K301 4.041676255
93B:B:H311 9.21254269
94B:B:W332 8.062867199
95B:B:D333 4.4775409
96B:B:K337 6.06754266
97B:B:W339 8.2625269
98G:G:V16 2.9225407
99G:G:L19 2.83409
100G:G:D48 7.17409
101G:G:F61 3.974588
102H:H:?1 14.5029720
103H:H:?3 17.885630
104H:H:?5 18.03630
105H:H:?9 14.114370
106X:X:?1 7.818181140
107X:X:W5 3.915410
108X:X:?6 9.842510
109R:R:Y20 4.65254292
110R:R:G30 2.31254489
111R:R:F38 5.4525427
112R:R:I40 5.675405
113R:R:H41 7.1527
114R:R:F42 7.27754503
115R:R:V44 4.04422
116R:R:P55 6.6954146
117R:R:Y63 5.90429725
118R:R:F65 7.066522
119R:R:R66 9.275425
120R:R:F68 7.56427
121R:R:R69 5.64333628
122R:R:W70 8.46833625
123R:R:L71 3.794504
124R:R:Q72 4.608527
125R:R:M74 3.19628
126R:R:F76 6.7125427
127R:R:I81 4.1625409
128R:R:L93 4.5375409
129R:R:Y95 7.508528
130R:R:I97 4.004528
131R:R:F98 8.568504
132R:R:C101 4.89428
133R:R:F114 4.3675405
134R:R:I135 5.1425294
135R:R:T145 4.418525
136R:R:V153 4.514126
137R:R:L157 4.2665127
138R:R:F160 6.04507
139R:R:P163 3.7775408
140R:R:Q164 5.4465128
141R:R:Y167 4.976528
142R:R:S169 4.1325408
143R:R:R172 5.7825404
144R:R:L173 4.8375405
145R:R:L174 8.1054127
146R:R:F180 6.7454125
147R:R:F183 7.3565128
148R:R:R185 7.1065129
149R:R:I187 3.985406
150R:R:F204 9.084157
151R:R:W206 7.6854159
152R:R:W208 6.18857739
153R:R:T211 4.1275405
154R:R:D216 3.1054386
155R:R:Y218 4.43507
156R:R:K225 5.865433
157R:R:E228 5.775433
158R:R:E229 5.4425435
159R:R:R233 6.778504
160R:R:D238 7.0625438
161R:R:F239 5.3536
162R:R:E241 5.0825435
163R:R:V266 5.3485157
164R:R:P274 3.366503
165R:R:D275 3.4385385
166R:R:L276 6.16254215
167R:R:E277 7.4275402
168R:R:E282 7.6365306
169R:R:R286 5.111676304
170R:R:W299 7.0845217
171R:R:L304 4.41754502
172R:R:I305 4.0065214
173R:R:F311 7.91403
174R:R:I327 4.745426
175R:R:F330 7.148528
176R:R:L334 6.54333626
177R:R:H338 7.115404
178R:R:N345 3.6525408
179R:R:F351 8.255626
180R:R:E353 5.27254567
181R:R:T355 6.305424
182R:R:F356 9.734528
183R:R:L360 6.824564
184R:R:R392 1.5425401
185R:R:Y408 7.652523
186R:R:Y411 7.525425
187R:R:L414 4.865426
188R:R:Y418 6.736527
189R:R:Y421 7.9075428
190R:R:W458 9.34254164
191R:R:Q459 8.48754167
192R:R:L461 4.37407
193R:R:F469 9.2854578
194R:R:N471 3.38833626
195R:R:M473 4.036524
196R:R:E475 3.8975425
197R:R:D484 7.68254128
198R:R:W494 6.6885217
199R:R:S497 3.4685583
200R:R:F505 5.36254214
201R:R:N512 7.4125424
202R:R:Y514 4.984524
203R:R:W530 6.667158
204R:R:T550 3.1854596
205R:R:C582 4.56754609
206R:R:W608 4.5825405
207R:R:L616 3.7875408
208R:R:G623 4.24254316
209R:R:L626 2.33754314
210R:R:V630 3.854237
211R:R:F637 3.474234
212R:R:N647 6.995409
213R:R:R648 4.205408
214R:R:F662 8.22754318
215R:R:F668 8.2275409
216R:R:P672 4.294229
217R:R:W675 5.4125403
218R:R:Q681 9.0025409
219R:R:F684 6.74833608
220R:R:F688 5.435408
221R:R:I692 4.52754637
222R:R:L696 4.234638
223R:R:R701 7.58254478
224R:R:F706 6.5945139
225R:R:W719 4.701676476
226R:R:Q724 6.715408
227R:R:P748 2.63409
228R:R:E757 8.9125434
229R:R:I760 5.564535
230R:R:I761 7.614227
231R:R:F762 6.36667637
232R:R:I777 3.908508
233R:R:F788 3.32408
234R:R:L797 3.58254138
235R:R:F801 5.4056139
236R:R:F814 5.815629
237R:R:F815 3.42407
238R:R:F821 4.03609
239R:R:P823 3.30254399
240R:R:Y829 5.506536
241R:R:F853 6.5545239
242R:R:K882 13.3754244
243R:R:V883 4.3745244
244S:S:F38 5.7125417
245S:S:H41 7.1517
246S:S:F42 8.07754643
247S:S:V44 3.645412
248S:S:P55 5.74166
249S:S:C60 5.635417
250S:S:Y63 5.73715
251S:S:F65 5.998512
252S:S:F68 7.3175417
253S:S:R69 7.8675418
254S:S:W70 9.37415
255S:S:L71 5.1025414
256S:S:Q72 4.67617
257S:S:M74 3.5625408
258S:S:I75 4.615414
259S:S:L87 4.442516
260S:S:Y95 6.92408
261S:S:F98 6.882504
262S:S:C101 5.504518
263S:S:F114 5.0775405
264S:S:I135 4.196676524
265S:S:T145 4.7375415
266S:S:V153 4.1525476
267S:S:L157 3.416577
268S:S:F160 6.316577
269S:S:I162 3.5225476
270S:S:P163 3.43667608
271S:S:Q164 5.128578
272S:S:Y167 5.7625418
273S:S:S169 4.54408
274S:S:L173 4.5265535
275S:S:L174 8.105477
276S:S:F180 7.274575
277S:S:F183 7.128578
278S:S:R185 6.626579
279S:S:Q193 4.978509
280S:S:W208 6.32875839
281S:S:Y218 4.9625417
282S:S:K225 6.2025403
283S:S:R233 7.83404
284S:S:D238 7.2125438
285S:S:F239 6.115436
286S:S:V266 5.78407
287S:S:V269 4.77254175
288S:S:F270 4.1775407
289S:S:P274 3.395643
290S:S:D275 3.1954665
291S:S:L276 5.865175
292S:S:I280 4.20754175
293S:S:E282 5.6925326
294S:S:R286 6.2685324
295S:S:I292 3.3054107
296S:S:L294 3.2875407
297S:S:W299 8.1354177
298S:S:L304 3.84254642
299S:S:I305 3.87254174
300S:S:Y310 6.42403
301S:S:F311 6.9975403
302S:S:F320 5.295406
303S:S:G325 4.305414
304S:S:I327 5.334516
305S:S:F330 5.61518
306S:S:L334 5.73167616
307S:S:V337 2.745415
308S:S:N345 3.268518
309S:S:F347 5.4875415
310S:S:F351 8.02333616
311S:S:W352 11.434518
312S:S:T355 6.6275414
313S:S:F356 11.54418
314S:S:L360 5.1404
315S:S:E399 7.425418
316S:S:Y408 7.155613
317S:S:Y411 8.74415
318S:S:L414 4.6575416
319S:S:Y418 6.99417
320S:S:Y421 8.986518
321S:S:F444 3.2625143
322S:S:W458 7.1465144
323S:S:Q459 6.7465147
324S:S:L461 5.024517
325S:S:F469 9.285418
326S:S:N471 4.17833616
327S:S:N472 4.75414
328S:S:M473 4.99667614
329S:S:D484 7.1525478
330S:S:N493 5.76754109
331S:S:W494 7.138336177
332S:S:H495 6.7825407
333S:S:Y511 5.618505
334S:S:N512 7.674374
335S:S:Y514 5.5845374
336S:S:L521 4.974105
337S:S:W530 6.331437108
338S:S:R551 7.2125407
339S:S:K552 7.9545188
340S:S:C582 4.64699
341S:S:W590 6.015406
342S:S:T596 1.97405
343S:S:C598 5.8254409
344S:S:E604 5.6375406
345S:S:W608 6.0175405
346S:S:E610 4.615407
347S:S:T627 4.3325407
348S:S:V630 4.5365277
349S:S:F634 4.2054279
350S:S:T640 4.065409
351S:S:I642 4.6225407
352S:S:L654 3.4254278
353S:S:L655 4.65254279
354S:S:F662 6.87754718
355S:S:F668 6.4575409
356S:S:P672 4.565449
357S:S:R680 5.046548
358S:S:Q681 5.354549
359S:S:F684 6.70857748
360S:S:F688 5.6975408
361S:S:R701 3.59508
362S:S:Q735 6.9225449
363S:S:W742 5.32549
364S:S:I763 4.265447
365S:S:L773 4.22448
366S:S:I777 3.385448
367S:S:F790 4.2407
368S:S:F801 4.7725409
369S:S:F809 5.4675409
370S:S:M811 3.9575409
371S:S:F814 8.065409
372S:S:W818 8.862549
373S:S:F821 5.272549
374S:S:Y825 7.8325449
375S:S:F832 4.7545395
376S:S:E837 5.595449
377S:S:V838 4.3675407
378S:S:F853 6.686279
379S:S:K863 14.73754737
380S:S:N867 8.0754739
381S:S:T868 8.035406
382S:S:R873 6.85254745
383W:W:?1 9.874449620
384W:W:W5 4.428520
385W:W:?6 9.68620
386W:W:?7 8.88111930
387X:X:?7 8.98556930
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:I80 16.15846.63YesNo098
2B:B:H54 B:B:S74 29.128713.95YesNo099
3B:B:D76 B:B:S74 29.29284.42NoNo099
4B:B:D76 B:B:G77 29.62691.68NoNo098
5B:B:G77 B:B:L95 29.96165.13NoYes088
6B:B:L95 B:B:Y124 31.10194.69YesYes3386
7B:B:V135 B:B:Y124 35.21616.31NoYes046
8B:B:R96 B:B:V135 35.38992.62NoNo064
9B:B:E138 B:B:R96 35.56385.82NoNo066
10B:B:E138 B:B:I120 35.74022.73NoYes066
11B:B:D118 B:B:I120 36.62452.8NoYes096
12B:B:D118 B:B:S97 36.80278.83NoNo098
13B:B:S97 B:B:W99 36.98136.18NoYes089
14A:A:F215 B:B:W99 39.14635.01YesYes599
15A:A:F215 A:A:L37 10010.96YesNo099
16A:A:L37 A:A:L39 1004.15NoYes099
17A:A:F223 A:A:L39 1002.44YesYes099
18A:A:F223 A:A:V225 1002.62YesYes097
19A:A:S246 A:A:V225 1001.62NoYes097
20A:A:A41 A:A:S246 1003.42NoNo079
21A:A:A41 A:A:S44 1001.71NoNo079
22A:A:A226 A:A:S44 1003.42NoNo089
23A:A:A226 A:A:K270 1004.82NoNo089
24A:A:K270 A:A:N269 1004.2NoNo099
25A:A:N269 A:A:T324 1005.85NoYes099
26A:A:F267 A:A:T324 1002.59NoYes099
27A:A:F267 A:A:H322 1005.66NoNo099
28A:A:F334 A:A:H322 10014.71NoNo039
29A:A:F334 R:R:K882 10031.02NoYes034
30A:A:D328 A:A:T324 1007.23YesYes4399
31A:A:D328 A:A:H322 1003.78YesNo099
32A:A:Q204 A:A:V201 68.57362.87YesYes599
33A:A:Q204 B:B:Y145 68.07694.51YesYes598
34B:B:G162 B:B:Y145 12.67644.35NoYes598
35B:B:G162 B:B:S161 12.42043.71NoNo099
36B:B:H142 B:B:S161 12.084416.74YesNo099
37A:A:F215 A:A:V201 1005.24YesYes599
38A:A:V201 A:A:W211 69.07444.9YesYes599
39A:A:W211 B:B:Y145 68.19393.86YesYes598
40B:B:D186 B:B:Y145 1003.45YesYes598
41B:B:D290 B:B:R314 12.025319.06NoNo068
42B:B:L70 B:B:W63 17.03411.39YesYes857
43B:B:L70 B:B:W82 23.32964.56YesYes859
44B:B:R314 B:B:W332 10.021316.99NoYes1989
45A:A:Y320 R:R:K882 10010.75YesYes2474
46A:A:Y320 R:R:V883 1005.05YesYes2474
47A:A:E318 R:R:V883 1002.85NoYes2444
48A:A:E318 R:R:R873 10012.79NoNo045
49A:A:Y354 R:R:R873 10011.32NoNo055
50B:B:C271 B:B:D290 13.58566.22YesNo056
51B:B:C271 B:B:Y289 14.24814.03YesYes1157
52B:B:I273 B:B:Y289 25.511110.88NoYes067
53B:B:G244 B:B:I273 36.82643.53NoNo056
54B:B:G244 B:B:T243 37.82043.64NoYes058
55B:B:F241 B:B:T243 19.03812.59YesYes968
56B:B:F222 B:B:F241 12.69468.57YesYes986
57B:B:D258 B:B:F222 23.38554.78YesYes978
58B:B:D258 B:B:R22 20.717314.29YesNo076
59B:B:I18 B:B:R22 14.03555.01NoNo076
60B:B:I18 G:G:A23 13.36731.62NoNo078
61B:B:L14 G:G:A23 12.03081.58NoNo088
62B:B:F253 B:B:T243 15.02983.89YesYes968
63B:B:F222 B:B:F253 12.69565.36YesYes986
64B:B:T321 B:B:W63 14.03039.7NoYes877
65B:B:D323 B:B:T321 13.36245.78NoNo877
66B:B:D323 B:B:M325 13.02884.16NoNo075
67B:B:M325 G:G:P49 12.6956.71NoNo057
68G:G:D48 G:G:P49 12.36113.22YesNo097
69B:B:S72 B:B:W82 12.47827.41NoYes099
70B:B:I229 B:B:T243 83.79336.08NoYes078
71B:B:G202 B:B:I229 84.12423.53NoNo067
72B:B:G202 B:B:S201 84.45531.86NoNo069
73B:B:H183 B:B:S201 92.98954.18YesNo099
74B:B:F180 B:B:T178 13.32863.89YesNo674
75B:B:D205 B:B:H183 1006.3YesYes699
76B:B:D205 B:B:G185 1003.35YesNo095
77B:B:F278 B:B:L285 12.67656.09YesNo1176
78B:B:C250 B:B:I273 10.98656.55NoNo086
79A:A:Y354 R:R:K644 1002.39NoNo058
80R:R:K644 R:R:R648 1009.9NoYes088
81R:R:R648 R:R:V643 1002.62YesNo089
82R:R:T640 R:R:V643 1003.17NoNo099
83R:R:F637 R:R:T640 1002.59YesNo049
84R:R:F637 R:R:V633 1002.62YesNo2345
85R:R:I857 R:R:V633 1003.07NoNo2385
86R:R:I857 R:R:V630 1003.07NoYes2387
87R:R:F853 R:R:V630 1003.93YesYes2397
88R:R:F853 R:R:I852 10011.3YesNo099
89R:R:I852 R:R:L848 1002.85NoNo097
90R:R:L848 R:R:S810 1003NoNo079
91R:R:M811 R:R:S810 1004.6NoNo099
92R:R:F788 R:R:M811 1003.73YesNo089
93R:R:F788 R:R:F815 1003.22YesYes087
94R:R:F814 R:R:F815 1006.43YesYes097
95R:R:F814 W:W:?1 1003.56YesYes6290
96R:R:I822 W:W:?1 1004.17NoYes070
97R:R:I822 R:R:P823 1003.39NoYes079
98R:R:P823 S:S:F832 1004.33YesYes3995
99S:S:F832 S:S:K831 1004.96YesNo059
100S:S:E604 S:S:K831 10012.15YesNo069
101S:S:E604 S:S:G830 1001.64YesNo068
102S:S:G830 X:X:?7 1001.64NoYes080
103R:R:E228 X:X:?7 68.194610.17YesYes330
104R:R:E228 R:R:K225 64.15024.05YesYes333
105R:R:E191 R:R:K225 64.29329.45NoYes033
106R:R:E191 R:R:N189 63.1673.94NoNo038
107R:R:D484 R:R:N189 63.09984.04YesNo088
108R:R:D484 R:R:R185 62.75915.48YesYes1289
109R:R:I187 R:R:R185 27.88683.76YesYes069
110R:R:I860 R:R:V643 1003.07NoNo099
111R:R:F637 R:R:I860 1005.02YesNo049
112R:R:F634 R:R:I857 1003.77NoNo2398
113R:R:F634 R:R:F853 1005.36NoYes2399
114S:S:E604 S:S:I760 36.19424.1YesNo065
115S:S:E757 S:S:I760 36.071210.93NoNo045
116S:S:E757 W:W:?7 36.016612.72NoYes040
117W:W:?7 X:X:?7 38.695824.22YesYes300
118S:S:D238 X:X:?7 43.57747.81YesYes380
119S:S:E228 W:W:?7 38.8526.36NoYes030
120S:S:E228 S:S:K225 38.57864.05NoYes033
121S:S:E229 S:S:K225 38.169310.8NoYes053
122S:S:E229 S:S:R233 37.89665.82NoYes054
123S:S:D199 S:S:R233 37.48758.34NoYes074
124S:S:D199 S:S:Y511 37.35133.45NoYes075
125S:S:E610 S:S:K831 24.73596.75YesNo079
126S:S:E610 S:S:L606 24.50045.3YesNo079
127S:S:L606 S:S:S834 23.95053NoNo098
128S:S:F668 S:S:S834 23.87195.28YesNo098
129S:S:E837 S:S:F668 20.26877YesYes099
130S:S:E837 X:X:?1 19.7895.8YesYes490
131S:S:F684 X:X:?1 16.494111.55YesYes480
132S:S:A196 S:S:Y511 34.60699.34NoYes085
133S:S:A196 S:S:F320 34.47074.16NoYes086
134S:S:F320 S:S:Q193 52.07287.03YesYes069
135S:S:E297 S:S:Q193 51.22796.37NoYes089
136S:S:E297 X:X:W5 50.18894.36NoYes080
137S:S:T145 X:X:W5 67.0154.85YesYes150
138S:S:D238 S:S:F239 40.91683.58YesYes386
139S:S:F239 S:S:G210 40.71079.03YesNo068
140S:S:G210 S:S:V209 40.64083.68NoNo088
141S:S:V209 S:S:V266 40.5714.81NoYes087
142S:S:L294 S:S:V266 37.83272.98YesYes077
143S:S:L294 S:S:V268 36.16664.47YesNo076
144S:S:M197 S:S:V268 35.44654.56NoNo076
145S:S:F320 S:S:M197 17.80276.22YesNo067
146S:S:F270 S:S:M197 17.59236.22YesNo077
147S:S:F270 S:S:S296 17.31223.96YesNo078
148S:S:S296 S:S:Y218 17.24595.09NoYes087
149S:S:Y218 X:X:W5 17.10443.86YesYes170
150S:S:E241 X:X:?7 10.73043.81NoYes050
151S:S:E241 S:S:V255 10.65717.13NoNo055
152S:S:L279 S:S:V255 10.58542.98NoNo055
153R:R:F183 R:R:R185 36.9817.48YesYes1289
154R:R:F183 R:R:Q164 36.70887.03YesYes1288
155R:R:L157 R:R:Q164 20.62726.65YesYes1278
156R:R:I187 R:R:L322 20.66152.85YesNo064
157R:R:E297 R:R:L322 20.5882.65NoNo084
158R:R:E297 W:W:W5 20.29246.54NoYes080
159R:R:Q164 R:R:V153 15.75585.73YesYes1286
160R:R:E241 W:W:?7 16.39333.81YesYes350
161R:R:E241 R:R:V255 15.98527.13YesNo055
162R:R:L279 R:R:V255 15.8524.47NoNo055
163R:R:I243 R:R:L279 13.73722.85NoNo055
164R:R:I212 R:R:I243 13.60584.42NoNo065
165R:R:I212 R:R:V269 12.80943.07NoNo065
166R:R:T111 R:R:V153 15.45626.35NoYes1276
167R:R:L156 R:R:T111 30.83845.9NoNo057
168R:R:L112 R:R:L156 30.68692.77NoNo055
169R:R:K119 R:R:L112 30.53554.23NoNo035
170R:R:K119 S:S:K119 30.38415.8NoNo033
171S:S:K119 S:S:L112 30.23254.23NoNo035
172S:S:L112 S:S:L156 30.08092.77NoNo055
173S:S:L156 S:S:T111 29.92944.42NoNo057
174S:S:L157 S:S:T111 22.14252.95YesNo777
175S:S:I162 S:S:L157 12.55122.85YesYes767
176R:R:L157 R:R:T111 15.53362.95YesNo1277
177S:S:T145 S:S:Y167 66.17813.75YesYes158
178S:S:F38 S:S:Y167 65.62210.32YesYes178
179S:S:F38 S:S:L71 48.25714.87YesYes174
180S:S:L71 S:S:N345 44.06014.12YesYes148
181S:S:F38 S:S:M74 17.10063.73YesYes078
182S:S:N345 S:S:Q72 36.80172.64YesYes187
183S:S:F68 S:S:Q72 12.65098.2YesYes177
184S:S:F351 S:S:F68 10.372111.79YesYes167
185S:S:Q72 S:S:V337 11.21822.87YesYes175
186S:S:F351 S:S:V337 10.37292.62YesYes165
187S:S:Q72 S:S:Y408 10.93245.64YesYes173
188S:S:F351 S:S:Y408 10.469915.47YesYes163
189S:S:F351 S:S:T355 27.81667.78YesYes164
190S:S:M74 S:S:V424 15.1383.04YesNo088
191S:S:A77 S:S:V424 14.85793.39NoNo088
192S:S:A77 S:S:Y421 14.57922.67NoYes088
193S:S:F356 S:S:T355 22.763411.67YesYes184
194S:S:F356 S:S:W352 18.548819.04YesYes188
195S:S:C661 S:S:F684 13.87182.79NoYes078
196S:S:C661 S:S:S845 13.55135.16NoNo078
197S:S:F662 S:S:S845 13.47129.25YesNo088
198S:S:F662 S:S:T627 13.15042.59YesYes087
199B:B:D186 B:B:G185 1001.68YesNo095
200B:B:C250 B:B:Y264 10.65262.69NoYes085
201B:B:H54 B:B:S72 12.64356.97YesNo099
202B:B:I80 B:B:W82 12.47811.74NoYes889
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8SZH
Class C
SubFamily Ion
Type Calcium Sensing
SubType CaS
Species Homo Sapiens
Ligand -
Other Ligand(s) Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.1
Date 2024-02-07
D.O.I. doi.org/10.1038/s41586-024-07055-2
Net Summary
Imin 2.59
Number of Linked Nodes 2167
Number of Links 2576
Number of Hubs 387
Number of Links mediated by Hubs 1414
Number of Communities 74
Number of Nodes involved in Communities 590
Number of Links involved in Communities 822
Path Summary
Number Of Nodes in MetaPath 203
Number Of Links MetaPath 202
Number of Shortest Paths 39813149
Length Of Smallest Path 3
Average Path Length 128
Length of Longest Path 102
Minimum Path Strength 1.16
Average Path Strength 8.05662
Maximum Path Strength 33.23
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.22581
Average % Of Corr. Nodes 108.518
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 69.4445
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • GDP binding   • G-protein beta/gamma-subunit complex binding   • signaling receptor binding   • G protein-coupled receptor binding   • cation binding   • metal ion binding   • cell division   • regulation of molecular function   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • positive regulation of autophagy   • catabolic process   • macroautophagy   • autophagy   • positive regulation of biological process   • regulation of catabolic process   • regulation of autophagy   • positive regulation of catabolic process   • positive regulation of metabolic process   • regulation of macroautophagy   • metabolic process   • positive regulation of macroautophagy   • process utilizing autophagic mechanism   • regulation of metabolic process   • positive regulation of cellular process   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • nucleoside phosphate metabolic process   • ribose phosphate metabolic process   • purine nucleoside triphosphate metabolic process   • GTP metabolic process   • carbohydrate derivative metabolic process   • primary metabolic process   • nucleotide metabolic process   • purine-containing compound metabolic process   • nucleobase-containing compound metabolic process   • purine nucleotide metabolic process   • ribonucleotide metabolic process   • organophosphate metabolic process   • nucleobase-containing small molecule metabolic process   • purine ribonucleoside triphosphate metabolic process   • phosphate-containing compound metabolic process   • small molecule metabolic process   • nucleoside triphosphate metabolic process   • purine ribonucleotide metabolic process   • phosphorus metabolic process   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body   • amino acid binding   • identical protein binding   • calcium ion binding   • phosphoric ester hydrolase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • phospholipase C activity   • phosphatidylinositol-4,5-bisphosphate phospholipase C activity   • phospholipase activity   • lipase activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • transmembrane transporter binding   • cell adhesion molecule binding   • integrin binding   • protein homodimerization activity   • protein dimerization activity   • kinase binding   • protein kinase binding   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • epithelium development   • tube development   • branching morphogenesis of an epithelial tube   • morphogenesis of an epithelium   • tissue development   • tissue morphogenesis   • anatomical structure morphogenesis   • tube morphogenesis   • morphogenesis of a branching structure   • epithelial tube morphogenesis   • morphogenesis of a branching epithelium   • regulation of tube diameter   • regulation of tube size   • regulation of system process   • positive regulation of vasoconstriction   • circulatory system process   • regulation of blood circulation   • vascular process in circulatory system   • regulation of vasoconstriction   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • blood vessel diameter maintenance   • vasoconstriction   • blood circulation   • regulation of anatomical structure size   • monoatomic ion transmembrane transport   • chloride transport   • transmembrane transport   • chloride transmembrane transport   • monoatomic anion transport   • monoatomic anion transmembrane transport   • inorganic anion transport   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • response to stress   • response to ischemia   • response to decreased oxygen levels   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to stress   • response to hypoxia   • response to oxygen levels   • response to abiotic stimulus   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • organic acid transport   • bile acid secretion   • organic anion transport   • monocarboxylic acid transport   • carboxylic acid transport   • secretion   • acid secretion   • response to peptide   • cellular response to peptide   • behavior   • chemosensory behavior   • JNK cascade   • MAPK cascade   • cellular response to low-density lipoprotein particle stimulus   • response to lipoprotein particle   • cellular response to lipoprotein particle stimulus   • regulation of calcium ion import   • positive regulation of calcium ion transport   • positive regulation of calcium ion import   • positive regulation of transport   • positive regulation of monoatomic ion transport   • calcium ion import   • ossification   • connective tissue development   • adipose tissue development   • fat pad development   • response to fibroblast growth factor   • response to growth factor   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • cellular response to glucose stimulus   • intracellular glucose homeostasis   • response to hexose   • cellular response to carbohydrate stimulus   • response to monosaccharide   • response to carbohydrate   • response to glucose   • glucose homeostasis   • carbohydrate homeostasis   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • response to nutrient levels   • response to nutrient   • response to vitamin   • cellular response to vitamin D   • cellular response to nutrient levels   • response to vitamin D   • cellular response to vitamin   • cellular response to nutrient   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • vasodilation   • positive chemotaxis   • chemotaxis   • positive regulation of locomotion   • regulation of response to external stimulus   • positive regulation of positive chemotaxis   • response to external stimulus   • regulation of chemotaxis   • positive regulation of chemotaxis   • regulation of positive chemotaxis   • positive regulation of response to external stimulus   • taxis   • regulation of locomotion   • locomotion   • response to hepatocyte growth factor   • cellular response to growth factor stimulus   • cellular response to hepatocyte growth factor stimulus   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • positive regulation of insulin secretion   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • regulation of protein secretion   • regulation of secretion   • positive regulation of protein localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • positive regulation of secretion   • amide transport   • signal release   • positive regulation of peptide secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • detection of stimulus   • response to metal ion   • detection of chemical stimulus   • detection of calcium ion   • response to calcium ion   • presynapse   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse   • somatodendritic compartment   • cell body   • neuronal cell body   • apical part of cell   • apical plasma membrane   • cell surface   • axon   • axon terminus   • distal axon   • neuron projection terminus
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • TNF receptor-like   • Type 1 solute binding protein-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • TNF receptor-like   • Type 1 solute binding protein-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8 H:H:?9
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylglucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodeYP4
PDB ResiduesX:X:?1 W:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeYP4
NameCinacalcet
Synonyms
  • (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine
  • Cinacalcet
  • Cinacalcet hydrochloride
  • CNC
  • N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine
Identifier
FormulaC22 H22 F3 N
Molecular Weight357.412
SMILES
PubChem156419
Formal Charge0
Total Atoms48
Total Chiral Atoms1
Total Bonds50
Total Aromatic Bonds17

CodeCA
PDB ResiduesX:X:?3 X:X:?4 W:W:?3 W:W:?4
Environment DetailsOpen EMBL-EBI Page
CodeCA
NameCALCIUM ION
Synonyms
Identifier
FormulaCa
Molecular Weight40.078
SMILES
PubChem
Formal Charge2
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

CodePO4
PDB ResiduesX:X:?6 W:W:?6
Environment DetailsOpen EMBL-EBI Page
CodePO4
NamePhosphate ion
Synonyms
  • Orthophosphate
  • Phosphate ion
  • Phosphate
Identifier
FormulaO4 P
Molecular Weight94.971
SMILES
PubChem1061
Formal Charge-3
Total Atoms5
Total Chiral Atoms0
Total Bonds4
Total Aromatic Bonds0

CodeSPM
PDB ResiduesW:W:?7 X:X:?7
Environment DetailsOpen EMBL-EBI Page
CodeSPM
NameSpermine
Synonyms4,9-diazadodecane-1,12-diamine
Identifier
FormulaC10 H26 N4
Molecular Weight202.34
SMILES
PubChem1103
Formal Charge0
Total Atoms40
Total Chiral Atoms0
Total Bonds39
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8SZH_Chain_A
AEDKAAVER SKMIDRNLR EDGEKAAKE VKLLLLGAG ESGKSTIVK 
QMKKTTGIV ETHFTFKDL YFKMFDVGG QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVLAEDEE MNRMHESMK LFDSICNNK WFTETSIIL 
FLNKKDLFE EKIKRSPLT ICYPEYTGS NTYEEAAAY IQCQFEDLN 
RRKDTKEIY THFTCATDT KNVQFVFDA VTDVIIKNN LKECGLY


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8SZH_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8SZH_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP41180
Sequence
>8SZH_Chain_R
YGPDQRAQK KGDIILGGL FPIHFGVAA KDQDLKSRP ESVECIRYN 
FRGFRWLQA MIFAIEEIN SSPALLPNL TLGYRIFDT CNTVSKALE 
ATLSFVAQN KIDSLNLCS EHIPSTIAV VGATGSGVS TAVANLLGL 
FYIPQVSYA SSSRLLSNK NQFKSFLRT IPNDEHQAT AMADIIEYF 
RWNWVGTIA ADDDYGRPG IEKFREEAE ERDICIDFS ELISQYSDE 
EEIQHVVEV IQNSTAKVI VVFSSGPDL EPLIKEIVR RNITGKIWL 
ASEAWASSS LIAMPQYFH VVGGTIGFA LKAGQIPGF REFLKKVHP 
RKSVHNGFA KEFWEETFN CHLQEFRPL CTGDENISS VETPYIDYT 
HLRISYNVY LAVYSIAHA LQDIYTCLP GRGLFTNGS CADIKKVEA 
WQVLKHLRH LNFTNNMGE QVTFDECGD LVGNYSIIN WHLSPEDGS 
IVFKEVGYY NVYAKKGER LFINEEKIL WSGFSREVP FSNCSRDCL 
AGTRKGIIE GEPTCCFEC VECPDGEYS DETDASACN KCPDDFWSN 
ENHTSCIAK EIEFLSWTE PFGIALTLF AVLGIFLTA FVLGVFIKF 
RNTPIVKAT NRELSYLLL FSLLCCFSS SLFFIGEPQ DWTCRLRQP 
AFGISFVLC ISCILVKTN RVLLVFEAK IPTSFHRKW WGLNLQFLL 
VFLCTFMQI VICVIWLYT APPSSYRNQ ELEDEIIFI TCHEGSLMA 
LGFLIGYTC LLAAICFFF AFKSRKLPE NFNEAKFIT FSMLIFFIV 
WISFIPAYA STYGKFVSA VEVIAILAA SFGLLACIF FNKIYIILF 
KPSRNTIEE VRCSTAAHA FKVAARA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP41180
Sequence
>8SZH_Chain_S
YGPDQRAQK KGDIILGGL FPIHFGVAA KDQDLKSRP ESVECIRYN 
FRGFRWLQA MIFAIEEIN SSPALLPNL TLGYRIFDT CNTVSKALE 
ATLSFVAQN KIDSLNLDC SEHIPSTIA VVGATGSGV STAVANLLG 
LFYIPQVSY ASSSRLLSN KNQFKSFLR TIPNDEHQA TAMADIIEY 
FRWNWVGTI AADDDYGRP GIEKFREEA EERDICIDF SELISQYSD 
EEEIQHVVE VIQNSTAKV IVVFSSGPD LEPLIKEIV RRNITGKIW 
LASEAWASS SLIAMPQYF HVVGGTIGF ALKAGQIPG FREFLKKVH 
PRKSVHNGF AKEFWEETF NCHLQERPL CTGDENISS VETPYIDYT 
HLRISYNVY LAVYSIAHA LQDIYTCLP GRGLFTNGS CADIKKVEA 
WQVLKHLRH LNFTNNMGE QVTFDECGD LVGNYSIIN WHLSPEDGS 
IVFKEVGYY NVYAKKGER LFINEEKIL WSGFSREVP FSNCSRDCL 
AGTRKGIIE GEPTCCFEC VECPDGEYS DETDASACN KCPDDFWSN 
ENHTSCIAK EIEFLSWTE PFGIALTLF AVLGIFLTA FVLGVFIKF 
RNTPIVKAT NRELSYLLL FSLLCCFSS SLFFIGEPQ DWTCRLRQP 
AFGISFVLC ISCILVKTN RVLLVFEAK NLQFLLVFL CTFMQIVIC 
VIWLYTAPP SSYRNQELE DEIIFITCH EGSLMALGF LIGYTCLLA 
AICFFFAFK SRKLPENFN EAKFITFSM LIFFIVWIS FIPAYASTY 
GKFVSAVEV IAILAASFG LLACIFFNK IYIILFKPS RNTIEEVRC 
ST


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WPGCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca-2.72023-11-22doi.org/10.1038/s41422-023-00892-2
8WPUCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(NtGi2L-Gs-CtGq)/β1/γ23.12023-11-22doi.org/10.1038/s41422-023-00892-2
8WPU (No Gprot) CIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca3.12023-11-22doi.org/10.1038/s41422-023-00892-2
7DTUCIonCalcium SensingCaSHomo sapiens-Tryptophan-4.42021-03-10doi.org/10.1038/s41422-021-00474-0
7M3JCIonCalcium SensingCaSHomo sapiens-NPS-2143; PO4-4.12021-06-30doi.org/10.1038/s41586-021-03691-0
7SINCIonCalcium SensingCaSHomo sapiens-NPS-2143-5.92022-01-19doi.org/10.1073/pnas.2115849118
9C1PCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan; '6218; PO4-2.82024-10-02doi.org/10.1126/science.ado1868
7DTVCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan-3.52021-03-10doi.org/10.1038/s41422-021-00474-0
7M3ECIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; NPS-2143-3.22021-06-30doi.org/10.1038/s41586-021-03691-0
7DD5CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; NPS-2143-3.22021-06-16doi.org/10.1126/sciadv.abg1483
7M3GCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4-2.52021-06-30doi.org/10.1038/s41586-021-03691-0
7DD7CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; Evocalcet-3.22021-06-16doi.org/10.1126/sciadv.abg1483
8SZFCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-2.82024-02-07doi.org/10.1038/s41586-024-07055-2
8SZGCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Sperminechim(NtGi1-Gq)/β1/γ23.62024-02-07doi.org/10.1038/s41586-024-07055-2
8SZG (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine3.62024-02-07doi.org/10.1038/s41586-024-07055-2
8SZHCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; SpermineGi1/β1/γ23.12024-02-07doi.org/10.1038/s41586-024-07055-2
8SZH (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine3.12024-02-07doi.org/10.1038/s41586-024-07055-2
7M3FCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4-2.82021-06-30doi.org/10.1038/s41586-021-03691-0
8SZICIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4Gi3/β1/γ23.52024-02-07doi.org/10.1038/s41586-024-07055-2
8SZI (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO43.52024-02-07doi.org/10.1038/s41586-024-07055-2
9C2FCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Tryptophan; '54149; PO4-2.82024-10-02doi.org/10.1126/science.ado1868
7DD6CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan-3.22021-06-16doi.org/10.1126/sciadv.abg1483
7SIMCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-2.72022-01-19doi.org/10.1073/pnas.2115849118
7E6TCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-32021-09-22doi.org/10.7554/eLife.68578
9ASBCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.42024-04-17doi.org/10.1038/s41586-024-07331-1
9ASB (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.42024-04-17doi.org/10.1038/s41586-024-07331-1
9AVGCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs)/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AVG (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AVLCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4Gi3/β2/γ23.82024-04-17doi.org/10.1038/s41586-024-07331-1
9AVL (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.82024-04-17doi.org/10.1038/s41586-024-07331-1
9AXFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.52024-04-17doi.org/10.1038/s41586-024-07331-1
9AXF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.52024-04-17doi.org/10.1038/s41586-024-07331-1
9AYFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4Gi1/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AYF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-17doi.org/10.1038/s41586-024-07331-1
7SILCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-2.72022-01-19doi.org/10.1073/pnas.2115849118
7DTTCIonCalcium SensingCaSHomo sapiensCaCa-3.82021-03-10doi.org/10.1038/s41422-021-00474-0
7DTWCIonCalcium SensingCaSHomo sapiens---4.52021-03-10doi.org/10.1038/s41422-021-00474-0
7E6UCIonCalcium SensingCaSHomo sapiens---62021-09-22doi.org/10.7554/eLife.68578




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