Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:L37 3.8125476
2R:R:F38 6.5925417
3R:R:P39 6.2475416
4R:R:H41 7.61517
5R:R:V44 3.645412
6R:R:R62 5.115404
7R:R:Y63 6.39715
8R:R:F65 6.518512
9R:R:R66 7.40833615
10R:R:F68 7.884517
11R:R:R69 8.7075418
12R:R:W70 7.8175815
13R:R:L71 4.3875414
14R:R:Q72 5.538517
15R:R:M74 5.226518
16R:R:I75 5.738514
17R:R:Y95 9.62408
18R:R:I97 6.0275418
19R:R:F98 7.31571774
20R:R:C101 5.2775418
21R:R:S113 5.255474
22R:R:F114 4.60333675
23R:R:K119 6.2785353
24R:R:N124 5.1545276
25R:R:E127 7.594364
26R:R:I135 4.0625404
27R:R:T145 5.15833615
28R:R:V153 4.51476
29R:R:L157 4.9925477
30R:R:F160 7.11754357
31R:R:P163 3.41833608
32R:R:Q164 5.034578
33R:R:Y167 7.1075418
34R:R:R172 6.844104
35R:R:L173 5.3925405
36R:R:F183 8.845408
37R:R:R185 8.00754109
38R:R:N189 5.44754108
39R:R:Q193 6.476519
40R:R:F204 8.65117
41R:R:W206 7.716676119
42R:R:W208 8.51599
43R:R:T211 4.8875405
44R:R:Y218 6.55717
45R:R:K225 7.1825103
46R:R:E229 7.814105
47R:R:R233 7.8425404
48R:R:F239 5.33167696
49R:R:Q245 7.8075404
50R:R:V258 6.56494
51R:R:V266 6.2225117
52R:R:F270 6.4875417
53R:R:P274 3.515403
54R:R:L276 5.535135
55R:R:E282 6.4054306
56R:R:R286 6.1225304
57R:R:W299 7.535137
58R:R:S302 4.20754135
59R:R:L304 4.8275402
60R:R:I305 4.176134
61R:R:F311 7.605403
62R:R:V313 4.5575403
63R:R:F320 5.438506
64R:R:I327 4.875416
65R:R:F330 6.21333618
66R:R:R331 7.2025404
67R:R:F333 8.2925417
68R:R:V337 4.4225415
69R:R:H338 8.2775414
70R:R:N345 3.74667618
71R:R:F351 9.44167616
72R:R:W352 10.0433618
73R:R:T355 7.025414
74R:R:F356 10.584518
75R:R:L360 6.245414
76R:R:R392 4.2775401
77R:R:E399 9.4675418
78R:R:Y408 7.945613
79R:R:L414 6.03516
80R:R:Y418 8.855187
81R:R:Y421 8.9975418
82R:R:Y425 10.87418
83R:R:Q432 5.0445297
84R:R:F444 4.51754283
85R:R:W458 10.6285284
86R:R:Q459 9.07754287
87R:R:L461 5.024227
88R:R:K462 5.124224
89R:R:H463 6.71405
90R:R:F469 10.265188
91R:R:N471 5.7565186
92R:R:M473 6.9585184
93R:R:D484 8.22254108
94R:R:N493 5.55254119
95R:R:W494 6.141437137
96R:R:S497 3.385403
97R:R:Y511 6.6654405
98R:R:N512 6.7654314
99R:R:I528 7.2985117
100R:R:W530 8.777147118
101R:R:V537 5.9854114
102R:R:E558 4.4054455
103R:R:Y573 8.5825486
104R:R:W590 6.674586
105R:R:S591 3.9875488
106R:R:L606 3.7425409
107R:R:W608 6.075405
108R:R:F612 5.625408
109R:R:T627 5.395407
110R:R:F634 4.79409
111R:R:T640 4.9725509
112R:R:L655 5.63254499
113R:R:F662 5.9465488
114R:R:Q681 5.805649
115R:R:F684 10.6575448
116R:R:F688 5.6375448
117R:R:V689 4.67254347
118R:R:F706 7.1054339
119R:R:W719 8.6454526
120R:R:Q735 5.45254349
121R:R:W742 4.922549
122R:R:I760 4.718585
123R:R:I761 6.3445477
124R:R:F762 4.91833687
125R:R:I763 5.0185327
126R:R:Y779 6.17754349
127R:R:L783 3.8854349
128R:R:C787 5.27448
129R:R:L797 4.0175408
130R:R:P798 6.53254339
131R:R:F806 5.23545
132R:R:I807 4.275409
133R:R:F809 4.29143749
134R:R:F814 5.48549
135R:R:W818 8.3475409
136R:R:F821 4.476509
137R:R:P823 3.572509
138R:R:E837 10.6925449
139R:R:I841 7.2725449
140R:R:L848 4.16447
141R:R:F853 7.48254499
142R:R:I857 4.3425408
143R:R:I859 4.855409
144S:S:Y20 5.55254272
145S:S:L37 3.436566
146S:S:F38 7.77427
147S:S:P39 5.65526
148S:S:H41 7.472537
149S:S:F42 11.465453
150S:S:V44 4.195402
151S:S:Y63 5.74714735
152S:S:F65 7.296532
153S:S:R66 8.662525
154S:S:F68 8.352537
155S:S:R69 7.1525428
156S:S:W70 7.28375825
157S:S:Q72 6.5475437
158S:S:M74 4.57628
159S:S:Y95 10.8325408
160S:S:I97 5.68528
161S:S:F98 7.026504
162S:S:C101 6.87438
163S:S:F114 4.488565
164S:S:K119 6.658503
165S:S:E127 7.87254374
166S:S:T145 5.36667625
167S:S:V153 4.51466
168S:S:L157 4.9925467
169S:S:P163 4.102508
170S:S:Q164 5.57468
171S:S:Y167 7.3175428
172S:S:R172 6.84754164
173S:S:L173 4.7985165
174S:S:F180 7.862505
175S:S:F183 7.62568
176S:S:L184 3.47406
177S:S:R185 7.0325469
178S:S:I187 4.374566
179S:S:P188 3.725468
180S:S:Q193 5.4275409
181S:S:F204 8.7754147
182S:S:W206 7.985149
183S:S:W208 7.596569
184S:S:V209 3.25754148
185S:S:Y218 7.66833627
186S:S:K225 6.9125163
187S:S:R227 8.86404
188S:S:R233 6.84167604
189S:S:F239 6.805406
190S:S:V258 4.81254574
191S:S:V266 7.32254147
192S:S:F270 4.975557
193S:S:G273 3.61454
194S:S:P274 3.48453
195S:S:D275 4.955405
196S:S:L276 6.702555
197S:S:E277 6.17452
198S:S:I280 4.92455
199S:S:R286 6.91254594
200S:S:W293 5.6554588
201S:S:W299 7.518557
202S:S:S302 3.8325455
203S:S:L304 5.60167652
204S:S:I305 4.16333654
205S:S:Y310 5.82403
206S:S:F311 6.7403
207S:S:H312 5.77754243
208S:S:V313 4.55754243
209S:S:V314 3.41407
210S:S:I327 6.5225426
211S:S:F330 6.24333628
212S:S:F333 8.4125407
213S:S:V337 4.0925435
214S:S:N345 4.702538
215S:S:F351 8.835636
216S:S:W352 11.13538
217S:S:T355 6.055434
218S:S:F356 9.8538
219S:S:L360 5.055404
220S:S:E399 9.0225438
221S:S:Y408 7.57333633
222S:S:Y411 10.755405
223S:S:L414 6.79426
224S:S:I416 9.155424
225S:S:Y418 8.02333627
226S:S:Y421 9.226528
227S:S:Y425 9.9675428
228S:S:Q432 6.55407
229S:S:F444 4.5954263
230S:S:W458 9.4445264
231S:S:Q459 7.5885267
232S:S:L461 5.62754217
233S:S:K462 5.154214
234S:S:N471 5.9625426
235S:S:M473 7.204524
236S:S:D484 8.945468
237S:S:W494 7.25857757
238S:S:S497 2.8725403
239S:S:Y511 6.03505
240S:S:N512 8.54254234
241S:S:V513 5.44233
242S:S:Y514 7.1845234
243S:S:W530 10.3685148
244S:S:P538 6.544148
245S:S:R551 8.12407
246S:S:Y573 6.21754646
247S:S:D588 3.2554206
248S:S:W590 8.17754636
249S:S:N594 13.6154653
250S:S:H595 5.24405
251S:S:W608 6.3525405
252S:S:E610 5.9175407
253S:S:F612 3.6625408
254S:S:T627 3.762507
255S:S:F634 5.1175409
256S:S:T646 4.13754199
257S:S:L655 7.30754259
258S:S:F662 6.4545668
259S:S:S665 2.76408
260S:S:F668 9.5454129
261S:S:Q681 7.6765129
262S:S:F684 9.1085128
263S:S:F688 6.14833608
264S:S:W742 4.90258129
265S:S:I761 6.494207
266S:S:F762 4.488507
267S:S:I763 3.974207
268S:S:L773 6.5854128
269S:S:L776 5.705408
270S:S:N800 6.9725197
271S:S:I807 4.045409
272S:S:F814 7.668509
273S:S:W818 9.766129
274S:S:F821 7.6954129
275S:S:Y829 8.05406
276S:S:F832 4.3275405
277S:S:E837 8.3685129
278S:S:F853 6.826259
279H:H:?1 16.34176310
280H:H:?3 16.3456150
281H:H:?5 21.5365230
282H:H:?7 19.655170
283W:W:?1 7.081010
284W:W:?2 8.80571710
285I:I:?2 5.65510
286W:W:?3 10.6571740
287X:X:?1 7.43920
288X:X:?2 10.7083620
289I:I:?6 6.3375420
290M:M:?1 4.698550
291X:X:?3 10.15810120
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:P163 R:R:V460 11.18063.53YesNo087
2R:R:I162 R:R:P163 18.57783.39NoYes068
3R:R:I162 R:R:L157 15.70595.71NoYes067
4R:R:F42 R:R:N64 10.734616.92NoNo034
5R:R:N64 R:R:R66 10.11163.62NoYes045
6R:R:F42 R:R:R62 10.70978.55NoYes034
7S:S:I162 S:S:P163 12.70453.39NoYes068
8S:S:I162 S:S:L157 13.26935.71NoYes067
9S:S:F114 S:S:F98 40.97285.36YesYes054
10S:S:F98 S:S:Y20 35.86518.25YesYes042
11S:S:E109 S:S:Y20 32.9337.86NoYes2752
12R:R:L159 S:S:E109 32.88286.63NoNo055
13R:R:F160 R:R:L159 32.76899.74YesNo075
14R:R:F160 R:R:N118 32.81558.46YesNo074
15R:R:I162 R:R:N118 32.70155.66NoNo064
16R:R:Q245 R:R:R62 11.88713.5YesYes044
17R:R:Q245 R:R:Y246 24.198918.04YesNo043
18R:R:Y246 S:S:N178 24.21925.81NoNo033
19S:S:N176 S:S:N178 24.23988.17NoNo063
20S:S:N176 S:S:Q179 24.26923.96NoNo065
21S:S:F180 S:S:Q179 24.299715.23YesNo055
22S:S:F114 S:S:L37 41.03193.65YesYes656
23S:S:L37 S:S:T100 55.3074.42YesNo067
24I:I:?6 S:S:T100 55.56678.13YesNo007
25S:S:Y218 X:X:?1 14.623521.07YesYes270
26S:S:D216 S:S:Y218 24.80585.75NoYes067
27S:S:A214 S:S:D216 24.79574.63NoNo056
28S:S:G553 S:S:R551 97.31191.5NoYes067
29S:S:G553 S:S:K552 97.3751.74NoNo068
30S:S:F563 S:S:K552 97.933816.13NoNo078
31S:S:F563 S:S:S543 97.99683.96NoNo078
32S:S:C542 S:S:S543 98.05973.44NoNo098
33S:S:C542 S:S:W208 98.01316.98NoYes5699
34S:S:D238 S:S:W208 99.875415.63NoYes089
35S:S:D238 S:S:S262 99.93778.83NoNo087
36S:S:F239 S:S:S262 1007.93YesNo067
37S:S:F239 S:S:I267 97.79585.02YesNo067
38S:S:I267 S:S:W293 97.83919.4NoYes5878
39S:S:V314 S:S:W293 73.74443.68YesYes078
40S:S:I280 S:S:V314 50.04233.07YesYes057
41S:S:I280 S:S:I305 24.3914.42YesYes554
42S:S:G273 S:S:I305 24.48863.53YesYes544
43M:M:?1 S:S:G273 24.37583.14YesYes504
44M:M:?1 S:S:F42 48.74496.72YesYes503
45S:S:F42 S:S:N64 74.057119.33YesNo034
46S:S:N64 S:S:P39 67.23463.26NoYes046
47I:I:?6 S:S:P39 53.59989.06YesYes206
48S:S:V314 S:S:W494 24.60213.68YesYes077
49S:S:I305 S:S:W494 48.93523.52YesYes547
50S:S:T317 S:S:W293 24.22866.06NoYes078
51S:S:T317 S:S:W494 24.280815.77NoYes077
52S:S:I305 S:S:S302 48.76453.1YesYes545
53M:M:?1 S:S:S302 24.37825.52YesYes505
54S:S:L304 S:S:S302 24.42143YesYes525
55S:S:F42 S:S:L304 24.887213.4YesYes532
56S:S:C582 S:S:R551 96.7974.18NoYes097
57S:S:C582 S:S:E572 95.78064.56NoNo097
58S:S:E572 S:S:P569 95.65324.72NoNo075
59R:R:P569 S:S:P569 95.58953.9NoNo055
60R:R:C582 R:R:P569 95.37163.77NoNo4695
61R:R:C568 R:R:C582 95.33437.28NoNo099
62R:R:C568 R:R:H595 95.07872.95NoNo095
63R:R:H595 R:R:S591 94.95085.58NoYes058
64R:R:S591 R:R:W590 94.23284.94YesYes886
65R:R:I761 R:R:K601 46.27085.82YesNo078
66R:R:K601 R:R:W590 46.34943.48NoYes086
67R:R:E759 R:R:W590 55.61619.81NoYes846
68R:R:F605 R:R:I763 45.29195.02NoYes3277
69R:R:I763 R:R:R752 22.89666.26YesNo073
70R:R:I761 R:R:R752 22.97825.01YesNo073
71R:R:I603 R:R:I763 22.89662.94NoYes047
72R:R:I603 R:R:I761 22.97822.94NoYes047
73R:R:F605 R:R:S607 45.13153.96NoNo077
74R:R:F612 R:R:L606 42.46994.87YesYes089
75R:R:K831 R:R:L606 44.30032.82NoYes099
76R:R:E610 R:R:K831 44.46669.45NoNo079
77R:R:E610 R:R:S607 44.79914.31NoNo077
78R:R:F612 R:R:L616 39.636610.96YesNo088
79R:R:L616 R:R:V838 39.46978.94NoNo087
80R:R:L842 R:R:V838 39.30282.98NoNo097
81R:R:L842 R:R:S665 38.96893NoNo098
82R:R:I841 R:R:S665 38.80194.64YesNo098
83R:R:F684 R:R:I841 32.386217.58YesYes489
84R:R:F684 R:R:F688 25.97787.5YesYes488
85R:R:F688 R:R:F809 15.31633.22YesYes489
86R:R:F809 R:R:L848 12.83653.65YesYes497
87R:R:I852 R:R:L848 10.79074.28NoYes097
88R:R:F853 R:R:I852 10.27887.54YesNo099
89R:R:E759 R:R:I760 55.54732.73NoYes845
90R:R:F762 R:R:I760 55.23611.3YesYes875
91R:R:F762 R:R:Y829 54.68183.09YesNo876
92R:R:Y829 S:S:Y829 54.633614.89NoYes066
93S:S:L756 S:S:Y829 27.32047.03NoYes056
94S:S:F762 S:S:L756 26.92138.53YesNo075
95S:S:E604 S:S:F762 53.51235.83NoYes067
96S:S:E604 S:S:K831 53.34910.8NoNo069
97S:S:F832 S:S:K831 52.20543.72YesNo059
98R:R:P823 S:S:F832 51.7152.89YesYes095
99R:R:P823 S:S:F612 50.56992.89YesYes098
100S:S:F612 S:S:L616 50.07886.09YesNo088
101S:S:L616 S:S:V838 49.91518.94NoNo087
102S:S:S665 S:S:V838 49.75143.23YesNo087
103S:S:I841 S:S:S665 29.40633.1NoYes098
104S:S:F684 S:S:I841 18.412311.3YesNo089
105S:S:F684 S:S:F688 13.983611.79YesYes088
106S:S:F688 S:S:L848 11.98984.87YesNo087
107S:S:L848 S:S:S810 11.82263NoNo079
108S:S:G830 S:S:Y829 26.98725.79NoYes086
109S:S:F762 S:S:G830 26.90743.01YesNo078
110S:S:S417 S:S:W70 11.46823.71NoYes265
111S:S:L414 S:S:S417 11.18477.51YesNo266
112S:S:I327 S:S:L414 10.24094.28YesYes266
113S:S:I327 S:S:Y421 10.397910.88YesYes268
114S:S:I187 S:S:R185 24.30563.76YesYes669
115S:S:S170 X:X:?1 12.77228.64NoYes070
116S:S:D190 S:S:S170 10.98898.83NoNo087
117S:S:D190 S:S:Y218 10.3065.75NoYes087
118S:S:A214 S:S:S271 26.37913.42NoNo054
119S:S:L276 S:S:S271 26.34636.01YesNo054
120S:S:F668 S:S:I841 10.90453.77YesNo099
121S:S:L842 S:S:S665 20.05583NoYes098
122S:S:F619 S:S:L842 19.88871.22NoNo039
123S:S:F619 S:S:L622 19.72181.22NoNo033
124S:S:G623 S:S:L622 19.38881.71NoNo063
125S:S:F662 S:S:G623 19.05439.03YesNo6686
126S:S:F662 S:S:T627 18.39152.59YesYes087
127S:S:L655 S:S:T627 10.20322.95YesYes097
128S:S:F634 S:S:F853 13.59687.5YesYes099
129S:S:F180 S:S:L174 23.67377.31YesNo057
130S:S:L174 S:S:R185 23.65494.86NoYes679
131S:S:I187 S:S:S170 23.71836.19YesNo067
132S:S:I280 S:S:L276 25.87458.56YesYes555
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F42 S:S:R62 6.41 5 Yes No 3 4 1 2
S:S:F42 S:S:N64 19.33 5 Yes No 3 4 1 2
S:S:F42 S:S:L304 13.4 5 Yes Yes 3 2 1 1
M:M:?1 S:S:F42 6.72 5 Yes Yes 0 3 0 1
S:S:E277 S:S:R62 6.98 5 Yes No 2 4 2 2
S:S:L304 S:S:R62 4.86 5 Yes No 2 4 1 2
S:S:P274 S:S:S272 3.56 5 Yes No 3 5 1 2
S:S:G273 S:S:P274 4.06 5 Yes Yes 4 3 1 1
S:S:G273 S:S:S302 3.71 5 Yes Yes 4 5 1 1
S:S:G273 S:S:I305 3.53 5 Yes Yes 4 4 1 2
M:M:?1 S:S:G273 3.14 5 Yes Yes 0 4 0 1
S:S:L304 S:S:P274 3.28 5 Yes Yes 2 3 1 1
M:M:?1 S:S:P274 3.02 5 Yes Yes 0 3 0 1
S:S:E277 S:S:L304 3.98 5 Yes Yes 2 2 2 1
S:S:L304 S:S:S302 3 5 Yes Yes 2 5 1 1
S:S:I305 S:S:S302 3.1 5 Yes Yes 4 5 2 1
M:M:?1 S:S:S302 5.52 5 Yes Yes 0 5 0 1
M:M:?1 S:S:L304 5.09 5 Yes Yes 0 2 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:P39 S:S:W70 4.05 2 Yes Yes 6 5 2 1
S:S:P39 S:S:T145 6.99 2 Yes Yes 6 5 2 1
I:I:?6 S:S:P39 9.06 2 Yes Yes 0 6 2 2
S:S:R66 S:S:R69 5.33 2 Yes Yes 5 8 1 2
S:S:R66 S:S:W70 10 2 Yes Yes 5 5 1 1
S:S:R66 X:X:?1 4.37 2 Yes Yes 5 0 1 0
S:S:R66 X:X:?2 20.97 2 Yes Yes 5 0 1 2
S:S:G67 S:S:W70 5.63 0 No Yes 4 5 2 1
S:S:R69 X:X:?2 9.78 2 Yes Yes 8 0 2 2
S:S:T145 S:S:W70 3.64 2 Yes Yes 5 5 1 1
S:S:I416 S:S:W70 18.79 2 Yes Yes 4 5 1 1
S:S:S417 S:S:W70 3.71 2 No Yes 6 5 2 1
S:S:W70 X:X:?1 3.28 2 Yes Yes 5 0 1 0
S:S:W70 X:X:?2 9.17 2 Yes Yes 5 0 1 2
S:S:T145 S:S:Y167 7.49 2 Yes Yes 5 8 1 2
S:S:A168 S:S:T145 3.36 0 No Yes 5 5 2 1
S:S:T145 X:X:?1 5.3 2 Yes Yes 5 0 1 0
I:I:?6 S:S:T145 5.42 2 Yes Yes 0 5 2 1
S:S:S147 S:S:S171 3.26 0 No No 8 7 1 2
S:S:S147 X:X:?1 5.4 0 No Yes 8 0 1 0
S:S:A168 S:S:I416 3.25 0 No Yes 5 4 2 1
S:S:I187 S:S:S170 6.19 6 Yes No 6 7 2 1
S:S:D190 S:S:S170 8.83 0 No No 8 7 2 1
S:S:S170 X:X:?1 8.64 0 No Yes 7 0 1 0
S:S:I187 S:S:L322 4.28 6 Yes No 6 4 2 2
S:S:D190 S:S:Q193 6.53 0 No Yes 8 9 2 2
S:S:D190 S:S:Y218 5.75 0 No Yes 8 7 2 1
S:S:Q193 S:S:S296 4.33 0 Yes No 9 8 2 2
S:S:E297 S:S:Q193 3.82 0 No Yes 8 9 1 2
S:S:D216 S:S:Y218 5.75 0 No Yes 6 7 2 1
S:S:G219 S:S:Y218 4.35 0 No Yes 7 7 2 1
S:S:S296 S:S:Y218 5.09 0 No Yes 8 7 2 1
S:S:A298 S:S:Y218 4 2 No Yes 6 7 1 1
S:S:Y218 X:X:?1 21.07 2 Yes Yes 7 0 1 0
S:S:E297 S:S:L322 14.58 0 No No 8 4 1 2
S:S:E297 X:X:?1 6.67 0 No Yes 8 0 1 0
S:S:A298 X:X:?1 9.06 2 No Yes 6 0 1 0
S:S:I416 X:X:?1 3.08 2 Yes Yes 4 0 1 0
S:S:I416 X:X:?2 11.5 2 Yes Yes 4 0 1 2
S:S:S417 X:X:?2 8.64 2 No Yes 6 0 2 2
S:S:R66 S:S:S301 2.64 2 Yes No 5 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F684 S:S:S664 5.28 12 Yes No 8 6 1 2
S:S:F668 S:S:Q681 3.51 12 Yes Yes 9 9 2 1
S:S:E837 S:S:F668 11.66 12 Yes Yes 9 9 1 2
S:S:F668 S:S:I841 3.77 12 Yes No 9 9 2 2
S:S:Q681 S:S:W742 3.29 12 Yes Yes 9 9 1 2
S:S:L773 S:S:Q681 6.65 12 Yes Yes 8 9 1 1
S:S:E837 S:S:Q681 6.37 12 Yes Yes 9 9 1 1
S:S:Q681 X:X:?3 18.56 12 Yes Yes 9 0 1 0
S:S:F684 S:S:F688 11.79 12 Yes Yes 8 8 1 2
S:S:F684 S:S:W818 3.01 12 Yes Yes 8 9 1 1
S:S:F684 S:S:I841 11.3 12 Yes No 8 9 1 2
S:S:F684 X:X:?3 14.16 12 Yes Yes 8 0 1 0
S:S:F688 S:S:F814 9.65 0 Yes Yes 8 9 2 2
S:S:T780 S:S:V689 4.76 0 No No 7 7 1 2
S:S:L773 S:S:W742 6.83 12 Yes Yes 8 9 1 2
S:S:I777 S:S:L773 4.28 12 No Yes 8 8 1 1
S:S:L773 X:X:?3 8.58 12 Yes Yes 8 0 1 0
S:S:I777 X:X:?3 7.74 12 No Yes 8 0 1 0
S:S:T780 X:X:?3 4.57 0 No Yes 7 0 1 0
S:S:F814 S:S:W818 11.02 0 Yes Yes 9 9 2 1
S:S:V817 S:S:W818 6.13 0 No Yes 9 9 2 1
S:S:F821 S:S:W818 12.03 12 Yes Yes 9 9 1 1
S:S:A840 S:S:W818 5.19 0 No Yes 9 9 2 1
S:S:W818 X:X:?3 21.18 12 Yes Yes 9 0 1 0
S:S:F821 S:S:Y825 10.32 12 Yes No 9 9 1 1
S:S:E837 S:S:F821 4.66 12 Yes Yes 9 9 1 1
S:S:F821 X:X:?3 3.77 12 Yes Yes 9 0 1 0
S:S:E837 S:S:Y825 7.86 12 Yes No 9 9 1 1
S:S:Y825 X:X:?3 9.08 12 No Yes 9 0 1 0
S:S:E837 X:X:?3 11.29 12 Yes Yes 9 0 1 0
S:S:G685 X:X:?3 2.65 0 No Yes 8 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:N64 R:R:R66 3.62 0 No Yes 4 5 2 1
R:R:R66 R:R:R69 4.26 1 Yes Yes 5 8 1 2
R:R:R66 R:R:W70 12 1 Yes Yes 5 5 1 2
R:R:R66 W:W:?1 6.12 1 Yes Yes 5 0 1 2
R:R:R66 W:W:?2 13.98 1 Yes Yes 5 0 1 2
L:L:?1 R:R:R66 4.47 0 No Yes 0 5 0 1
R:R:R69 W:W:?2 13.98 1 Yes Yes 8 0 2 2
R:R:W70 W:W:?1 3.28 1 Yes Yes 5 0 2 2
R:R:W70 W:W:?2 7.86 1 Yes Yes 5 0 2 2
R:R:G273 R:R:S302 3.71 13 No Yes 4 5 2 1
R:R:G273 R:R:I305 3.53 13 No Yes 4 4 2 2
R:R:L304 R:R:S302 4.5 0 Yes Yes 2 5 2 1
R:R:I305 R:R:S302 3.1 13 Yes Yes 4 5 2 1
L:L:?1 R:R:S302 5.52 0 No Yes 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P39 R:R:W70 4.05 1 Yes Yes 6 5 2 1
R:R:P39 R:R:T145 6.99 1 Yes Yes 6 5 2 1
I:I:?2 R:R:P39 9.06 1 Yes Yes 0 6 2 2
R:R:N64 R:R:R66 3.62 0 No Yes 4 5 2 1
R:R:G67 R:R:N64 3.39 0 No No 4 4 2 2
R:R:R66 R:R:R69 4.26 1 Yes Yes 5 8 1 2
R:R:R66 R:R:W70 12 1 Yes Yes 5 5 1 1
R:R:R66 W:W:?1 6.12 1 Yes Yes 5 0 1 0
R:R:R66 W:W:?2 13.98 1 Yes Yes 5 0 1 2
L:L:?1 R:R:R66 4.47 0 No Yes 0 5 2 1
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:R69 W:W:?2 13.98 1 Yes Yes 8 0 2 2
R:R:T145 R:R:W70 3.64 1 Yes Yes 5 5 1 1
R:R:I416 R:R:W70 21.14 1 No Yes 4 5 2 1
R:R:S417 R:R:W70 4.94 1 No Yes 6 5 2 1
R:R:W70 W:W:?1 3.28 1 Yes Yes 5 0 1 0
R:R:W70 W:W:?2 7.86 1 Yes Yes 5 0 1 2
R:R:T145 R:R:Y167 6.24 1 Yes Yes 5 8 1 2
R:R:A168 R:R:T145 3.36 1 No Yes 5 5 1 1
R:R:T145 W:W:?1 5.3 1 Yes Yes 5 0 1 0
I:I:?2 R:R:T145 5.42 1 Yes Yes 0 5 2 1
R:R:S147 R:R:S171 4.89 1 No No 8 7 1 2
R:R:S147 R:R:Y218 3.82 1 No Yes 8 7 1 1
R:R:S147 W:W:?1 6.48 1 No Yes 8 0 1 0
R:R:A168 W:W:?1 3.4 1 No Yes 5 0 1 0
R:R:D190 R:R:S170 8.83 0 No No 8 7 2 1
R:R:S170 W:W:?1 8.64 0 No Yes 7 0 1 0
R:R:D190 R:R:Q193 7.83 0 No Yes 8 9 2 2
R:R:D190 R:R:Y218 5.75 0 No Yes 8 7 2 1
R:R:Q193 R:R:S296 4.33 1 Yes No 9 8 2 2
R:R:E297 R:R:Q193 3.82 0 No Yes 8 9 1 2
R:R:D216 R:R:Y218 3.45 0 No Yes 6 7 2 1
R:R:G219 R:R:Y218 4.35 0 No Yes 7 7 2 1
R:R:S296 R:R:Y218 5.09 1 No Yes 8 7 2 1
R:R:A298 R:R:Y218 4 1 No Yes 6 7 1 1
R:R:Y218 W:W:?1 19.39 1 Yes Yes 7 0 1 0
R:R:E297 R:R:L322 15.9 0 No No 8 4 1 2
R:R:E297 W:W:?1 6.67 0 No Yes 8 0 1 0
R:R:A298 W:W:?1 9.06 1 No Yes 6 0 1 0
R:R:I416 W:W:?2 8.21 1 No Yes 4 0 2 2
R:R:S417 W:W:?2 8.64 1 No Yes 6 0 2 2
R:R:G146 W:W:?1 2.46 0 No Yes 5 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F684 R:R:S664 5.28 4 Yes No 8 6 1 2
R:R:I841 R:R:S664 3.1 4 Yes No 9 6 2 2
R:R:E837 R:R:F668 15.16 4 Yes No 9 9 1 2
R:R:F668 R:R:I841 3.77 0 No Yes 9 9 2 2
R:R:P682 R:R:Q681 3.16 0 No Yes 5 9 2 1
R:R:Q681 R:R:W742 3.29 4 Yes Yes 9 9 1 2
R:R:E767 R:R:Q681 7.65 4 No Yes 7 9 2 1
R:R:L773 R:R:Q681 5.32 4 No Yes 8 9 2 1
R:R:E837 R:R:Q681 5.1 4 Yes Yes 9 9 1 1
R:R:Q681 W:W:?3 10.31 4 Yes Yes 9 0 1 0
R:R:F684 R:R:F688 7.5 4 Yes Yes 8 8 1 2
R:R:F684 R:R:I841 17.58 4 Yes Yes 8 9 1 2
R:R:F684 W:W:?3 12.27 4 Yes Yes 8 0 1 0
R:R:F688 R:R:F814 4.29 4 Yes Yes 8 9 2 2
R:R:T780 R:R:V689 4.76 0 No Yes 7 7 1 2
R:R:L773 R:R:W742 3.42 4 No Yes 8 9 2 2
R:R:E767 R:R:L773 5.3 4 No No 7 8 2 2
R:R:I777 W:W:?3 6.64 0 No Yes 8 0 1 0
R:R:T780 W:W:?3 4.57 0 No Yes 7 0 1 0
R:R:F814 R:R:W818 11.02 4 Yes Yes 9 9 2 1
R:R:A844 R:R:W818 3.89 0 No Yes 9 9 2 1
R:R:W818 W:W:?3 15.89 0 Yes Yes 9 0 1 0
R:R:E837 R:R:Y825 11.22 4 Yes No 9 9 1 1
R:R:Y825 W:W:?3 13.63 4 No Yes 9 0 1 0
R:R:E837 W:W:?3 11.29 4 Yes Yes 9 0 1 0
R:R:A840 R:R:W818 2.59 0 No Yes 9 9 2 1
R:R:G778 R:R:I777 1.76 0 No No 5 8 2 1
R:R:C781 R:R:I777 1.64 0 No No 7 8 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9AXF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.96
Number of Linked Nodes 1591
Number of Links 1918
Number of Hubs 291
Number of Links mediated by Hubs 1089
Number of Communities 66
Number of Nodes involved in Communities 470
Number of Links involved in Communities 642
Path Summary
Number Of Nodes in MetaPath 133
Number Of Links MetaPath 132
Number of Shortest Paths 11823518
Length Of Smallest Path 3
Average Path Length 55.1177
Length of Longest Path 95
Minimum Path Strength 1.22
Average Path Strength 7.0248
Maximum Path Strength 35.4
Minimum Path Correlation 0.7
Average Path Correlation 0.999208
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.53846
Average % Of Corr. Nodes 54.528
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.6667
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • amino acid binding   • identical protein binding   • protein binding   • cation binding   • ion binding   • calcium ion binding   • metal ion binding   • small molecule binding   • phosphoric ester hydrolase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • phospholipase C activity   • hydrolase activity   • phosphatidylinositol-4,5-bisphosphate phospholipase C activity   • catalytic activity   • phospholipase activity   • lipase activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • transmembrane transporter binding   • cell adhesion molecule binding   • protein-containing complex binding   • integrin binding   • signaling receptor binding   • protein homodimerization activity   • protein dimerization activity   • kinase binding   • enzyme binding   • protein kinase binding   • biological regulation   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • regulation of biological process   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization
Gene OntologyBiological Process• biological regulation   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • regulation of biological process   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • developmental process   • multicellular organismal process   • epithelium development   • tube development   • branching morphogenesis of an epithelial tube   • morphogenesis of an epithelium   • tissue development   • tissue morphogenesis   • anatomical structure morphogenesis   • multicellular organism development   • tube morphogenesis   • morphogenesis of a branching structure   • anatomical structure development   • epithelial tube morphogenesis   • morphogenesis of a branching epithelium   • regulation of tube diameter   • system process   • regulation of tube size   • regulation of system process   • positive regulation of biological process   • positive regulation of vasoconstriction   • circulatory system process   • regulation of blood circulation   • vascular process in circulatory system   • regulation of vasoconstriction   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • blood vessel diameter maintenance   • vasoconstriction   • blood circulation   • regulation of anatomical structure size   • monoatomic ion transmembrane transport   • chloride transport   • transmembrane transport   • chloride transmembrane transport   • monoatomic anion transport   • monoatomic anion transmembrane transport   • cellular process   • inorganic anion transport   • regulation of biosynthetic process   • regulation of cellular process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • response to stimulus   • response to stress   • response to ischemia   • response to decreased oxygen levels   • cellular response to stimulus   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to chemical stimulus   • cellular response to stress   • response to hypoxia   • response to chemical   • response to oxygen levels   • response to abiotic stimulus   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • organic acid transport   • bile acid secretion   • organic anion transport   • monocarboxylic acid transport   • carboxylic acid transport   • secretion   • acid secretion   • response to peptide   • cellular response to peptide   • behavior   • chemosensory behavior   • signaling   • intracellular signal transduction   • cell communication   • JNK cascade   • intracellular signaling cassette   • MAPK cascade   • signal transduction   • cellular response to low-density lipoprotein particle stimulus   • response to endogenous stimulus   • response to lipoprotein particle   • response to nitrogen compound   • cellular response to lipoprotein particle stimulus   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • regulation of calcium ion import   • positive regulation of calcium ion transport   • positive regulation of calcium ion import   • positive regulation of transport   • positive regulation of monoatomic ion transport   • calcium ion import   • ossification   • connective tissue development   • adipose tissue development   • fat pad development   • animal organ development   • response to fibroblast growth factor   • response to growth factor   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • response to oxygen-containing compound   • cellular response to glucose stimulus   • intracellular glucose homeostasis   • cellular response to oxygen-containing compound   • response to hexose   • cellular response to carbohydrate stimulus   • response to monosaccharide   • response to carbohydrate   • response to glucose   • glucose homeostasis   • carbohydrate homeostasis   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • response to nutrient levels   • response to lipid   • response to nutrient   • response to vitamin   • cellular response to vitamin D   • cellular response to nutrient levels   • response to vitamin D   • cellular response to vitamin   • cellular response to lipid   • cellular response to nutrient   • cell population proliferation   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • vasodilation   • positive chemotaxis   • chemotaxis   • positive regulation of locomotion   • regulation of response to external stimulus   • positive regulation of positive chemotaxis   • response to external stimulus   • regulation of chemotaxis   • positive regulation of chemotaxis   • regulation of positive chemotaxis   • positive regulation of response to external stimulus   • taxis   • regulation of locomotion   • locomotion   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular response to endogenous stimulus   • response to hepatocyte growth factor   • cellular response to growth factor stimulus   • cellular response to hepatocyte growth factor stimulus   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • positive regulation of insulin secretion   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • regulation of protein secretion   • regulation of secretion   • positive regulation of protein localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • positive regulation of secretion   • amide transport   • signal release   • positive regulation of peptide secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • detection of stimulus   • response to metal ion   • detection of chemical stimulus   • detection of calcium ion   • response to calcium ion   • cell periphery   • presynapse   • cellular anatomical structure   • synapse   • cell junction   • membrane   • plasma membrane   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse
Gene OntologyCellular Component• cell periphery   • presynapse   • cellular anatomical structure   • synapse   • cell junction   • membrane   • plasma membrane   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse   • somatodendritic compartment   • cell body   • neuronal cell body   • apical part of cell   • apical plasma membrane   • cell surface   • axon   • neuron projection   • axon terminus   • plasma membrane bounded cell projection   • cell projection   • distal axon   • neuron projection terminus   • binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • D2 dopamine receptor binding   • adenylate cyclase inhibitor activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • enzyme inhibitor activity   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • cell-cell signaling   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • cell division   • leukocyte migration   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • negative regulation of peptide hormone secretion   • negative regulation of establishment of protein localization   • negative regulation of protein secretion   • negative regulation of signaling   • negative regulation of cell communication   • negative regulation of peptide secretion   • negative regulation of cellular process   • negative regulation of protein localization   • negative regulation of insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • cilium   • ciliary basal body   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • cell population proliferation   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Type 1 solute binding protein-like   • TNF receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Type 1 solute binding protein-like   • TNF receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8 H:H:?9 H:H:?10 H:H:?11 H:H:?12 H:H:?13 H:H:?14 H:H:?15 H:H:?16
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylglucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodeTCR
PDB ResiduesW:W:?1 X:X:?1
Environment DetailsOpen EMBL-EBI Page
CodeTCR
NameCYCLOMETHYLTRYPTOPHAN
Synonyms
Identifier
FormulaC12 H12 N2 O2
Molecular Weight216.236
SMILES
PubChem449440
Formal Charge0
Total Atoms28
Total Chiral Atoms1
Total Bonds30
Total Aromatic Bonds10

CodePO4
PDB ResiduesW:W:?2 X:X:?2
Environment DetailsOpen EMBL-EBI Page
CodePO4
NamePhosphate ion
Synonyms
  • Orthophosphate
  • Phosphate ion
  • Phosphate
Identifier
FormulaO4 P
Molecular Weight94.971
SMILES
PubChem1061
Formal Charge-3
Total Atoms5
Total Chiral Atoms0
Total Bonds4
Total Aromatic Bonds0

CodeCA
PDB ResiduesI:I:?2 L:L:?1 I:I:?3 I:I:?5 I:I:?6 M:M:?1 I:I:?7
Environment DetailsOpen EMBL-EBI Page
CodeCA
NameCALCIUM ION
Synonyms
Identifier
FormulaCa
Molecular Weight40.078
SMILES
PubChem
Formal Charge2
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

Code9IG
PDB ResiduesW:W:?3 X:X:?3
Environment DetailsOpen EMBL-EBI Page
Code9IG
Name3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine
Synonyms
Identifier
FormulaC18 H22 Cl N O
Molecular Weight303.826
SMILES
PubChem158797
Formal Charge0
Total Atoms43
Total Chiral Atoms1
Total Bonds44
Total Aromatic Bonds12

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41180
Sequence
>9AXF_nogp_Chain_R
YGPDQRAQK KGDIILGGL FPIHFGVAA KDQDLKSRP ESVECIRYN 
FRGFRWLQA MIFAIEEIN SSPALLPNL TLGYRIFDT CNTVSKALE 
ATLSFVAQN KIDSLNLDE FCNCSEHIP STIAVVGAT GSGVSTAVA 
NLLGLFYIP QVSYASSSR LLSNKNQFK SFLRTIPND EHQATAMAD 
IIEYFRWNW VGTIAADDD YGRPGIEKF REEAEERDI CIDFSELIS 
QYSDEEEIQ HVVEVIQNS TAKVIVVFS SGPDLEPLI KEIVRRNIT 
GKIWLASEA WASSSLIAM PQYFHVVGG TIGFALKAG QIPGFREFL 
KKVHPRKSV HNGFAKEFW EETFNCHLR PLCTGDENI SSVETPYID 
YTHLRISYN VYLAVYSIA HALQDIYTC LPGRGLFTN GSCADIKKV 
EAWQVLKHL RHLNFTNNM GEQVTFDEC GDLVGNYSI INWHLSPED 
GSIVFKEVG YYNVYAKKG ERLFINEEK ILWSGFSRE VPFSNCSRD 
CLAGTRKGI IEGEPTCCF ECVECPDGE YSDETDASA CNKCPDDFW 
SNENHTSCI AKEIEFLSW TEPFGIALT LFAVLGIFL TAFVLGVFI 
KFRNTPIVK ATNRELSYL LLFSLLCCF SSSLFFIGE PQDWTCRLR 
QPAFGISFV LCISCILVK TNRVLLVFE AKIPTSFHR KWWGLNLQF 
LLVFLCTFM QIVICVIWL YTAPPSSYR NQELEDEII FITCHEGSL 
MALGFLIGY TCLLAAICF FFAFKSRKL PENFNEAKF ITFSMLIFF 
IVWISFIPA YASTYGKFV SAVEVIAIL AASFGLLAC IFFNKIYII 
LFKPSRNTI EEVRCSTAA HAFK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP41180
Sequence
>9AXF_nogp_Chain_S
YGPDQRAQK KGDIILGGL FPIHFGVAA KDQDLKSRP ESVECIRYN 
FRGFRWLQA MIFAIEEIN SSPALLPNL TLGYRIFDT CNTVSKALE 
ATLSFVAQN KIDSLNLDE FCNCSEHIP STIAVVGAT GSGVSTAVA 
NLLGLFYIP QVSYASSSR LLSNKNQFK SFLRTIPND EHQATAMAD 
IIEYFRWNW VGTIAADDD YGRPGIEKF REEAEERDI CIDFSELIS 
QYSDEEEIQ HVVEVIQNS TAKVIVVFS SGPDLEPLI KEIVRRNIT 
GKIWLASEA WASSSLIAM PQYFHVVGG TIGFALKAG QIPGFREFL 
KKVHPRKSV HNGFAKEFW EETFNCHLR PLCTGDENI SSVETPYID 
YTHLRISYN VYLAVYSIA HALQDIYTC LPGRGLFTN GSCADIKKV 
EAWQVLKHL RHLNFTNNM GEQVTFDEC GDLVGNYSI INWHLSPED 
GSIVFKEVG YYNVYAKKG ERLFINEEK ILWSGFSRE VPFSNCSRD 
CLAGTRKGI IEGEPTCCF ECVECPDGE YSDETDASA CNKCPDDFW 
SNENHTSCI AKEIEFLSW TEPFGIALT LFAVLGIFL TAFVLGVFI 
KFRNTPIVK ATNRELSYL LLFSLLCCF SSSLFFIGE PQDWTCRLR 
QPAFGISFV LCISCILVK TNLQFLLVF LCTFMQIVI CVIWLYTAP 
PSSYRNQEL EDEIIFITC HEGSLMALG FLIGYTCLL AAICFFFAF 
KSRKLPENF NEAKFITFS MLIFFIVWI SFIPAYAST YGKFVSAVE 
VIAILAASF GLLACIFFN KIYIILFK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WPGCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca-2.72023-11-22doi.org/10.1038/s41422-023-00892-2
8WPUCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(NtGi2L-Gs-CtGq)/β1/γ23.12023-11-22doi.org/10.1038/s41422-023-00892-2
8WPU (No Gprot) CIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca3.12023-11-22doi.org/10.1038/s41422-023-00892-2
7DTUCIonCalcium SensingCaSHomo sapiens-Tryptophan-4.42021-03-10doi.org/10.1038/s41422-021-00474-0
7M3JCIonCalcium SensingCaSHomo sapiens-NPS-2143; PO4-4.12021-06-30doi.org/10.1038/s41586-021-03691-0
7SINCIonCalcium SensingCaSHomo sapiens-NPS-2143-5.92022-01-19doi.org/10.1073/pnas.2115849118
9C1PCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan; '6218; PO4-2.82024-10-02doi.org/10.1126/science.ado1868
7DTVCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan-3.52021-03-10doi.org/10.1038/s41422-021-00474-0
7M3ECIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; NPS-2143-3.22021-06-30doi.org/10.1038/s41586-021-03691-0
7DD5CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; NPS-2143-3.22021-06-16doi.org/10.1126/sciadv.abg1483
7M3GCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4-2.52021-06-30doi.org/10.1038/s41586-021-03691-0
7DD7CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; Evocalcet-3.22021-06-16doi.org/10.1126/sciadv.abg1483
8SZFCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-2.82024-02-07doi.org/10.1038/s41586-024-07055-2
8SZGCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Sperminechim(NtGi1-Gq)/β1/γ23.62024-02-07doi.org/10.1038/s41586-024-07055-2
8SZG (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine3.62024-02-07doi.org/10.1038/s41586-024-07055-2
8SZHCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; SpermineGi1/β1/γ23.12024-02-07doi.org/10.1038/s41586-024-07055-2
8SZH (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine3.12024-02-07doi.org/10.1038/s41586-024-07055-2
7M3FCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4-2.82021-06-30doi.org/10.1038/s41586-021-03691-0
8SZICIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4Gi3/β1/γ23.52024-02-07doi.org/10.1038/s41586-024-07055-2
8SZI (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO43.52024-02-07doi.org/10.1038/s41586-024-07055-2
9C2FCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Tryptophan; '54149; PO4-2.82024-10-02doi.org/10.1126/science.ado1868
7DD6CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan-3.22021-06-16doi.org/10.1126/sciadv.abg1483
7SIMCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-2.72022-01-19doi.org/10.1073/pnas.2115849118
7E6TCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-32021-09-22doi.org/10.7554/eLife.68578
9ASBCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.42024-04-17doi.org/10.1038/s41586-024-07331-1
9ASB (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.42024-04-17doi.org/10.1038/s41586-024-07331-1
9AVGCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs)/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AVG (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AVLCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4Gi3/β2/γ23.82024-04-17doi.org/10.1038/s41586-024-07331-1
9AVL (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.82024-04-17doi.org/10.1038/s41586-024-07331-1
9AXFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.52024-04-17doi.org/10.1038/s41586-024-07331-1
9AXF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.52024-04-17doi.org/10.1038/s41586-024-07331-1
9AYFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4Gi1/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AYF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-17doi.org/10.1038/s41586-024-07331-1
7SILCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-2.72022-01-19doi.org/10.1073/pnas.2115849118
7DTTCIonCalcium SensingCaSHomo sapiensCaCa-3.82021-03-10doi.org/10.1038/s41422-021-00474-0
7DTWCIonCalcium SensingCaSHomo sapiens---4.52021-03-10doi.org/10.1038/s41422-021-00474-0
7E6UCIonCalcium SensingCaSHomo sapiens---62021-09-22doi.org/10.7554/eLife.68578




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9AXF_nogp.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.