Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:L37 3.8125476
2R:R:F38 6.5925417
3R:R:P39 6.2475416
4R:R:H41 7.61517
5R:R:V44 3.645412
6R:R:R62 5.115404
7R:R:Y63 6.39715
8R:R:F65 6.518512
9R:R:R66 7.40833615
10R:R:F68 7.884517
11R:R:R69 8.7075418
12R:R:W70 7.8175815
13R:R:L71 4.3875414
14R:R:Q72 5.538517
15R:R:M74 4.84167618
16R:R:I75 5.27167614
17R:R:Y95 9.62418
18R:R:I97 5.41518
19R:R:F98 7.31571774
20R:R:C101 5.2775418
21R:R:S113 5.255474
22R:R:F114 4.60333675
23R:R:K119 6.2785303
24R:R:N124 5.1545226
25R:R:E127 7.594314
26R:R:I135 4.0625404
27R:R:T145 5.15833615
28R:R:V153 4.51476
29R:R:L157 4.584577
30R:R:F160 7.11754307
31R:R:P163 3.41833608
32R:R:Q164 5.034578
33R:R:Y167 7.1075418
34R:R:R172 6.844104
35R:R:L173 5.3925405
36R:R:F183 8.845408
37R:R:R185 8.00754109
38R:R:N189 5.44754108
39R:R:Q193 6.476519
40R:R:F204 8.6517
41R:R:W206 7.71667619
42R:R:W208 7.52667669
43R:R:T211 4.8875405
44R:R:Y218 6.55717
45R:R:K225 7.1825103
46R:R:E229 7.814105
47R:R:R233 7.8425404
48R:R:F239 5.33167666
49R:R:Q245 7.8075404
50R:R:V266 6.222517
51R:R:I267 5.36467
52R:R:F270 6.4875417
53R:R:P274 3.515403
54R:R:L276 5.535125
55R:R:E282 6.4054266
56R:R:R286 6.1225264
57R:R:W299 7.535127
58R:R:S302 4.20754125
59R:R:L304 4.8275402
60R:R:I305 4.176124
61R:R:F311 7.605403
62R:R:V313 4.5575403
63R:R:F320 5.438516
64R:R:I327 4.875416
65R:R:F330 6.21333618
66R:R:R331 7.2025414
67R:R:F333 8.2925417
68R:R:V337 4.4225415
69R:R:H338 8.2775414
70R:R:N345 3.74667618
71R:R:F351 9.44167616
72R:R:W352 10.0433618
73R:R:T355 7.025414
74R:R:F356 10.584518
75R:R:L360 6.245414
76R:R:R392 4.2775401
77R:R:E399 9.4675418
78R:R:Y408 7.945613
79R:R:I409 3.9125415
80R:R:L414 6.03516
81R:R:Y418 8.855147
82R:R:Y421 8.9975418
83R:R:Y425 10.87418
84R:R:Q432 5.0445257
85R:R:F444 4.51754233
86R:R:W458 10.6285234
87R:R:Q459 9.07754237
88R:R:L461 5.024187
89R:R:K462 5.124184
90R:R:H463 6.71405
91R:R:F469 10.265148
92R:R:N471 5.7565146
93R:R:M473 6.038336144
94R:R:D484 8.22254108
95R:R:I491 2.896518
96R:R:N493 5.5525419
97R:R:W494 6.141437127
98R:R:S497 3.2965383
99R:R:Y511 6.6654365
100R:R:N512 3.65404
101R:R:I523 3.374516
102R:R:I528 6.57167617
103R:R:W530 8.77714718
104R:R:V537 5.985414
105R:R:E558 4.4054415
106R:R:Y573 8.5825496
107R:R:W590 6.674596
108R:R:S591 3.9875498
109R:R:L606 3.7425409
110R:R:W608 6.075405
111R:R:F612 5.625408
112R:R:T627 5.395407
113R:R:F634 4.79409
114R:R:T640 4.9725469
115R:R:I642 5.7675407
116R:R:L655 5.63254459
117R:R:F662 5.9465448
118R:R:Q681 5.805639
119R:R:F684 10.6575438
120R:R:F688 5.6375438
121R:R:V689 4.67254297
122R:R:F706 7.1054289
123R:R:W719 8.6454486
124R:R:Q735 5.45254299
125R:R:W742 4.922539
126R:R:I760 4.718595
127R:R:I761 6.3445437
128R:R:F762 4.91833697
129R:R:I763 5.0185277
130R:R:Y779 6.17754299
131R:R:L783 3.8854299
132R:R:C787 5.27438
133R:R:L797 4.0175408
134R:R:P798 6.53254289
135R:R:F806 5.23535
136R:R:I807 4.275409
137R:R:F809 4.29143739
138R:R:F814 5.48539
139R:R:W818 8.3475409
140R:R:F821 4.476509
141R:R:P823 3.572509
142R:R:E837 10.6925439
143R:R:I841 7.2725439
144R:R:L848 4.16437
145R:R:F853 7.48254459
146R:R:I857 4.3425408
147R:R:I859 4.855409
148S:S:Y20 5.55254222
149S:S:L37 3.436546
150S:S:F38 7.77427
151S:S:P39 5.65526
152S:S:H41 7.472527
153S:S:F42 11.465453
154S:S:V44 4.195402
155S:S:Y63 5.74714725
156S:S:F65 7.296522
157S:S:R66 8.662525
158S:S:F68 8.352527
159S:S:R69 7.1525428
160S:S:W70 7.28375825
161S:S:Q72 6.5475427
162S:S:M74 4.57628
163S:S:I75 6.1975424
164S:S:Y95 10.8325428
165S:S:I97 5.22333628
166S:S:F98 7.026504
167S:S:C101 6.87428
168S:S:F114 4.488545
169S:S:K119 6.658503
170S:S:E127 7.87254324
171S:S:T145 5.36667625
172S:S:V153 4.51446
173S:S:L157 4.584547
174S:S:P163 4.102508
175S:S:Q164 5.57448
176S:S:Y167 7.3175428
177S:S:R172 6.84754134
178S:S:L173 4.7985135
179S:S:L174 8.0425447
180S:S:F180 7.862545
181S:S:F183 7.62548
182S:S:L184 3.47406
183S:S:R185 7.0325449
184S:S:I187 4.374546
185S:S:P188 3.725448
186S:S:Q193 5.4275409
187S:S:I200 3.8525488
188S:S:F204 8.775487
189S:S:W206 7.98589
190S:S:W208 7.596529
191S:S:V209 3.2575488
192S:S:Y218 7.66833627
193S:S:K225 6.9125133
194S:S:R227 8.86404
195S:S:R233 6.84167604
196S:S:F239 6.805406
197S:S:V266 7.3225487
198S:S:I267 5.434197
199S:S:F270 4.975517
200S:S:G273 3.61454
201S:S:P274 3.48453
202S:S:D275 4.955405
203S:S:L276 6.702555
204S:S:E277 6.17452
205S:S:I280 4.92455
206S:S:I283 3.34404
207S:S:R286 6.91254194
208S:S:I288 5.14754194
209S:S:W293 5.6554198
210S:S:W299 7.518557
211S:S:S302 3.8325455
212S:S:L304 5.60167652
213S:S:I305 4.16333654
214S:S:Y310 5.82403
215S:S:F311 6.7403
216S:S:V313 4.55754543
217S:S:V314 3.41407
218S:S:I327 6.5225426
219S:S:F330 6.24333628
220S:S:F333 8.4125407
221S:S:V337 4.0925425
222S:S:N345 4.702528
223S:S:F351 8.835626
224S:S:W352 11.13528
225S:S:T355 6.055424
226S:S:F356 9.8528
227S:S:L360 5.055404
228S:S:E399 9.0225428
229S:S:Y408 7.57333623
230S:S:Y411 10.755405
231S:S:L414 6.79426
232S:S:I416 9.155424
233S:S:Y418 8.02333627
234S:S:Y421 9.226528
235S:S:Y425 9.9675428
236S:S:Q432 6.55407
237S:S:F444 4.5954213
238S:S:W458 9.4445214
239S:S:Q459 7.5885217
240S:S:L461 5.62754177
241S:S:K462 5.154174
242S:S:N471 5.9625426
243S:S:M473 7.204524
244S:S:D484 8.945448
245S:S:W494 7.25857757
246S:S:S497 2.8725403
247S:S:Y511 6.03505
248S:S:N512 4.81254244
249S:S:V513 5.44243
250S:S:Y514 6.08754244
251S:S:I523 4.5525486
252S:S:W530 10.368588
253S:S:P538 6.54488
254S:S:R551 8.12407
255S:S:Y573 6.21754596
256S:S:D588 3.2554166
257S:S:W590 8.17754586
258S:S:H595 5.24405
259S:S:W608 6.3525405
260S:S:E610 5.9175407
261S:S:F612 3.6625408
262S:S:T627 3.762507
263S:S:F634 5.1175409
264S:S:T646 4.13754159
265S:S:L655 7.30754209
266S:S:F662 6.4545608
267S:S:S665 2.76408
268S:S:F668 9.5454119
269S:S:Q681 7.6765119
270S:S:F684 9.1085118
271S:S:F688 6.14833608
272S:S:W742 4.90258119
273S:S:I761 6.494167
274S:S:F762 4.488507
275S:S:I763 3.974167
276S:S:L773 6.5854118
277S:S:L776 5.705408
278S:S:N800 6.9725157
279S:S:I807 4.045409
280S:S:F814 7.668509
281S:S:W818 9.766119
282S:S:F821 7.6954119
283S:S:Y829 8.05406
284S:S:F832 4.3275405
285S:S:E837 8.3685119
286S:S:F853 6.826209
287W:W:?1 7.081010
288W:W:?2 8.80571710
289I:I:?2 5.65510
290W:W:?3 10.6571730
291X:X:?1 7.43920
292X:X:?2 10.7083620
293I:I:?6 5.65520
294M:M:?1 4.698550
295X:X:?3 10.15810110
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:R66 R:R:R69 16.05854.26YesYes158
2R:R:I162 R:R:P163 16.76093.39NoYes068
3R:R:I162 R:R:L157 17.28995.71NoYes067
4R:R:F42 R:R:N64 23.510516.92NoNo034
5R:R:N64 R:R:R66 21.48943.62NoYes045
6R:R:F42 R:R:R62 23.46718.55NoYes034
7S:S:I162 S:S:P163 11.82943.39NoYes068
8S:S:I162 S:S:L157 12.45585.71NoYes067
9S:S:F114 S:S:F98 36.7065.36YesYes054
10S:S:F98 S:S:Y20 31.90398.25YesYes042
11S:S:E109 S:S:Y20 29.07157.86NoYes2252
12R:R:L159 S:S:E109 29.12786.63NoNo055
13R:R:F160 R:R:L159 29.0539.74YesNo075
14R:R:F160 R:R:N118 29.50828.46YesNo074
15R:R:I162 R:R:N118 29.43335.66NoNo064
16R:R:Q245 R:R:R62 25.8583.5YesYes044
17R:R:D216 R:R:Y218 26.48533.45NoYes067
18R:R:A214 R:R:D216 26.54974.63NoNo056
19R:R:A214 R:R:D275 29.38923.09NoNo055
20R:R:D275 R:R:Q245 29.51476.53NoYes054
21R:R:F330 R:R:R69 12.48323.21YesYes188
22R:R:Q245 R:R:Y246 68.63718.04YesNo043
23R:R:Y246 S:S:N178 68.67635.81NoNo033
24S:S:N176 S:S:N178 68.71648.17NoNo063
25S:S:N176 S:S:Q179 68.77463.96NoNo065
26S:S:F180 S:S:Q179 68.834815.23YesNo055
27S:S:F114 S:S:L37 36.29253.65YesYes456
28R:R:D190 R:R:Y218 11.11155.75NoYes087
29S:S:L37 S:S:T100 22.82854.42YesNo067
30I:I:?6 S:S:T100 22.91148.13YesNo007
31I:I:?6 S:S:T145 33.81045.42YesYes205
32S:S:T145 X:X:?1 28.68035.3YesYes250
33S:S:Y218 X:X:?1 63.532321.07YesYes270
34S:S:D216 S:S:Y218 92.96935.75NoYes067
35S:S:A214 S:S:D216 92.93184.63NoNo056
36S:S:A144 S:S:L37 22.80173.15NoYes066
37I:I:?6 S:S:A144 22.84312.9YesNo006
38R:R:S296 R:R:Y218 11.32845.09NoYes187
39R:R:F320 R:R:Q193 23.909410.54YesYes169
40R:R:F320 R:R:I491 14.23583.77YesYes168
41R:R:F204 R:R:I523 13.14463.77YesYes176
42R:R:I212 R:R:V269 11.36496.14NoNo065
43R:R:F239 R:R:I267 12.47285.02YesYes667
44R:R:D238 R:R:F239 10.08093.58NoYes686
45R:R:G273 R:R:P274 12.85844.06NoYes043
46S:S:G553 S:S:R551 98.15571.5NoYes067
47S:S:G553 S:S:K552 98.20321.74NoNo068
48S:S:F563 S:S:K552 98.695716.13NoNo078
49S:S:F563 S:S:S543 98.93113.96NoNo078
50S:S:C542 S:S:S543 98.97813.44NoNo098
51S:S:C542 S:S:W208 98.795816.98NoYes5299
52S:S:D238 S:S:W208 99.90815.63NoYes089
53S:S:D238 S:S:S262 99.9548.83NoNo087
54S:S:F239 S:S:S262 1007.93YesNo067
55S:S:F239 S:S:I267 96.6615.02YesYes067
56S:S:I212 S:S:I267 92.71412.94NoYes067
57S:S:I212 S:S:I243 93.06484.42NoNo065
58S:S:I243 S:S:S271 93.10553.1NoNo054
59S:S:A214 S:S:S271 95.95063.42NoNo054
60S:S:C582 S:S:R551 97.83914.18NoYes097
61S:S:C582 S:S:E572 97.06584.56NoNo097
62S:S:E572 S:S:P569 96.96834.72NoNo075
63R:R:P569 S:S:P569 96.91953.9NoNo055
64R:R:C582 R:R:P569 96.71773.77NoNo4295
65R:R:C568 R:R:C582 96.72397.28NoNo099
66R:R:C568 R:R:H595 96.52762.95NoNo095
67R:R:H595 R:R:S591 96.42925.58NoYes058
68R:R:S591 R:R:W590 95.85764.94YesYes986
69R:R:I761 R:R:K601 52.44125.82YesNo078
70R:R:K601 R:R:W590 52.52043.48NoYes086
71R:R:E759 R:R:W590 60.05199.81NoYes946
72R:R:I603 R:R:I761 26.06212.94NoYes047
73R:R:I603 R:R:I763 25.97652.94NoYes047
74R:R:I761 R:R:R752 26.06215.01YesNo073
75R:R:I763 R:R:R752 25.97656.26YesNo073
76R:R:F605 R:R:I763 51.41445.02NoYes2777
77R:R:F605 R:R:S607 51.24913.96NoNo077
78R:R:F612 R:R:L606 48.4024.87YesYes089
79R:R:K831 R:R:L606 50.36062.82NoYes099
80R:R:E610 R:R:K831 50.53849.45NoNo079
81R:R:E610 R:R:S607 50.89384.31NoNo077
82R:R:F612 R:R:L616 45.36510.96YesNo088
83R:R:L616 R:R:V838 45.18598.94NoNo087
84R:R:L842 R:R:V838 45.00682.98NoNo097
85R:R:L842 R:R:S665 44.64853NoNo098
86R:R:I841 R:R:S665 44.46924.64YesNo098
87R:R:F684 R:R:I841 37.508517.58YesYes389
88R:R:F684 R:R:F688 30.56537.5YesYes388
89R:R:F688 R:R:F809 18.97573.22YesYes389
90R:R:F809 R:R:L848 16.35743.65YesYes397
91R:R:I852 R:R:L848 14.12094.28NoYes097
92R:R:F853 R:R:I852 13.56077.54YesNo099
93R:R:E759 R:R:I760 59.99172.73NoYes945
94R:R:F762 R:R:I760 59.677111.3YesYes975
95R:R:F762 R:R:Y829 59.10753.09YesNo976
96R:R:Y829 S:S:Y829 59.089714.89NoYes066
97S:S:L756 S:S:Y829 29.55227.03NoYes056
98S:S:F762 S:S:L756 29.13868.53YesNo075
99S:S:E604 S:S:F762 57.92395.83NoYes067
100S:S:E604 S:S:K831 57.751110.8NoNo069
101S:S:F832 S:S:K831 56.53973.72YesNo059
102R:R:P823 S:S:F832 56.01992.89YesYes095
103R:R:P823 S:S:F612 54.63182.89YesYes098
104S:S:F612 S:S:L616 54.11066.09YesNo088
105S:S:L616 S:S:V838 53.93688.94NoNo087
106S:S:S665 S:S:V838 53.76293.23YesNo087
107S:S:I841 S:S:S665 31.79943.1NoYes098
108S:S:F684 S:S:I841 19.942811.3YesNo089
109S:S:F684 S:S:F688 15.23311.79YesYes088
110S:S:F688 S:S:L848 13.08774.87YesNo087
111S:S:L848 S:S:S810 12.90693NoNo079
112S:S:G830 S:S:Y829 29.19295.79NoYes086
113S:S:F762 S:S:G830 29.11013.01YesNo078
114I:I:?6 S:S:P39 11.97819.06YesYes206
115S:S:F42 S:S:N64 10.409919.33YesNo034
116S:S:R66 X:X:?1 13.49044.37YesYes250
117S:S:R66 S:S:R69 16.63055.33YesYes258
118S:S:F330 S:S:R69 11.35413.21YesYes288
119S:S:F330 S:S:L334 10.153814.61YesNo086
120S:S:L334 S:S:Y408 19.79529.38NoYes063
121S:S:I187 S:S:R185 70.64133.76YesYes469
122S:S:S170 X:X:?1 37.73978.64NoYes070
123S:S:D190 S:S:S170 31.578.83NoNo087
124S:S:D190 S:S:Y218 29.98395.75NoYes087
125S:S:I401 S:S:V337 10.13033.07NoYes075
126S:S:I401 S:S:W352 18.29724.7NoYes078
127S:S:P339 S:S:W352 10.351920.27NoYes078
128S:S:F668 S:S:I841 11.83463.77YesNo099
129S:S:L842 S:S:S665 21.69393NoYes098
130S:S:F619 S:S:L842 21.51321.22NoNo039
131S:S:F619 S:S:L622 21.33281.22NoNo033
132S:S:G623 S:S:L622 20.97381.71NoNo063
133S:S:F662 S:S:G623 20.61179.03YesNo6086
134S:S:F662 S:S:T627 19.90032.59YesYes087
135S:S:L655 S:S:T627 11.04442.95YesYes097
136S:S:F634 S:S:F853 14.76417.5YesYes099
137S:S:F634 S:S:S651 10.37813.96YesNo099
138S:S:F180 S:S:L174 66.39297.31YesYes457
139S:S:L174 S:S:R185 66.48174.86YesYes479
140S:S:I187 S:S:S170 69.20766.19YesNo067
141R:R:G273 R:R:I305 12.58723.53NoYes1244
142R:R:P274 R:R:Q245 13.31783.16YesYes034
143R:R:D190 R:R:Q193 10.93757.83NoYes089
144R:R:Q193 R:R:S296 10.93444.33YesNo198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F42 S:S:R62 6.41 5 Yes No 3 4 1 2
S:S:F42 S:S:N64 19.33 5 Yes No 3 4 1 2
S:S:F42 S:S:L304 13.4 5 Yes Yes 3 2 1 1
M:M:?1 S:S:F42 6.72 5 Yes Yes 0 3 0 1
S:S:E277 S:S:R62 6.98 5 Yes No 2 4 2 2
S:S:L304 S:S:R62 4.86 5 Yes No 2 4 1 2
S:S:P274 S:S:S272 3.56 5 Yes No 3 5 1 2
S:S:G273 S:S:P274 4.06 5 Yes Yes 4 3 1 1
S:S:G273 S:S:S302 3.71 5 Yes Yes 4 5 1 1
S:S:G273 S:S:I305 3.53 5 Yes Yes 4 4 1 2
M:M:?1 S:S:G273 3.14 5 Yes Yes 0 4 0 1
S:S:L304 S:S:P274 3.28 5 Yes Yes 2 3 1 1
M:M:?1 S:S:P274 3.02 5 Yes Yes 0 3 0 1
S:S:E277 S:S:L304 3.98 5 Yes Yes 2 2 2 1
S:S:L304 S:S:S302 3 5 Yes Yes 2 5 1 1
S:S:I305 S:S:S302 3.1 5 Yes Yes 4 5 2 1
M:M:?1 S:S:S302 5.52 5 Yes Yes 0 5 0 1
M:M:?1 S:S:L304 5.09 5 Yes Yes 0 2 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:P39 S:S:W70 4.05 2 Yes Yes 6 5 2 1
S:S:P39 S:S:T145 6.99 2 Yes Yes 6 5 2 1
I:I:?6 S:S:P39 9.06 2 Yes Yes 0 6 2 2
S:S:R66 S:S:R69 5.33 2 Yes Yes 5 8 1 2
S:S:R66 S:S:W70 10 2 Yes Yes 5 5 1 1
S:S:R66 X:X:?1 4.37 2 Yes Yes 5 0 1 0
S:S:R66 X:X:?2 20.97 2 Yes Yes 5 0 1 2
S:S:G67 S:S:W70 5.63 0 No Yes 4 5 2 1
S:S:R69 X:X:?2 9.78 2 Yes Yes 8 0 2 2
S:S:T145 S:S:W70 3.64 2 Yes Yes 5 5 1 1
S:S:I416 S:S:W70 18.79 2 Yes Yes 4 5 1 1
S:S:S417 S:S:W70 3.71 2 No Yes 6 5 2 1
S:S:W70 X:X:?1 3.28 2 Yes Yes 5 0 1 0
S:S:W70 X:X:?2 9.17 2 Yes Yes 5 0 1 2
S:S:T145 S:S:Y167 7.49 2 Yes Yes 5 8 1 2
S:S:A168 S:S:T145 3.36 0 No Yes 5 5 2 1
S:S:T145 X:X:?1 5.3 2 Yes Yes 5 0 1 0
I:I:?6 S:S:T145 5.42 2 Yes Yes 0 5 2 1
S:S:S147 S:S:S171 3.26 0 No No 8 7 1 2
S:S:S147 X:X:?1 5.4 0 No Yes 8 0 1 0
S:S:A168 S:S:I416 3.25 0 No Yes 5 4 2 1
S:S:I187 S:S:S170 6.19 4 Yes No 6 7 2 1
S:S:D190 S:S:S170 8.83 0 No No 8 7 2 1
S:S:S170 X:X:?1 8.64 0 No Yes 7 0 1 0
S:S:I187 S:S:L322 4.28 4 Yes No 6 4 2 2
S:S:D190 S:S:Q193 6.53 0 No Yes 8 9 2 2
S:S:D190 S:S:Y218 5.75 0 No Yes 8 7 2 1
S:S:Q193 S:S:S296 4.33 0 Yes No 9 8 2 2
S:S:E297 S:S:Q193 3.82 0 No Yes 8 9 1 2
S:S:D216 S:S:Y218 5.75 0 No Yes 6 7 2 1
S:S:G219 S:S:Y218 4.35 0 No Yes 7 7 2 1
S:S:S296 S:S:Y218 5.09 0 No Yes 8 7 2 1
S:S:A298 S:S:Y218 4 2 No Yes 6 7 1 1
S:S:Y218 X:X:?1 21.07 2 Yes Yes 7 0 1 0
S:S:E297 S:S:L322 14.58 0 No No 8 4 1 2
S:S:E297 X:X:?1 6.67 0 No Yes 8 0 1 0
S:S:A298 X:X:?1 9.06 2 No Yes 6 0 1 0
S:S:I416 X:X:?1 3.08 2 Yes Yes 4 0 1 0
S:S:I416 X:X:?2 11.5 2 Yes Yes 4 0 1 2
S:S:S417 X:X:?2 8.64 2 No Yes 6 0 2 2
S:S:R66 S:S:S301 2.64 2 Yes No 5 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F684 S:S:S664 5.28 11 Yes No 8 6 1 2
S:S:F668 S:S:Q681 3.51 11 Yes Yes 9 9 2 1
S:S:E837 S:S:F668 11.66 11 Yes Yes 9 9 1 2
S:S:F668 S:S:I841 3.77 11 Yes No 9 9 2 2
S:S:Q681 S:S:W742 3.29 11 Yes Yes 9 9 1 2
S:S:L773 S:S:Q681 6.65 11 Yes Yes 8 9 1 1
S:S:E837 S:S:Q681 6.37 11 Yes Yes 9 9 1 1
S:S:Q681 X:X:?3 18.56 11 Yes Yes 9 0 1 0
S:S:F684 S:S:F688 11.79 11 Yes Yes 8 8 1 2
S:S:F684 S:S:W818 3.01 11 Yes Yes 8 9 1 1
S:S:F684 S:S:I841 11.3 11 Yes No 8 9 1 2
S:S:F684 X:X:?3 14.16 11 Yes Yes 8 0 1 0
S:S:F688 S:S:F814 9.65 0 Yes Yes 8 9 2 2
S:S:T780 S:S:V689 4.76 0 No No 7 7 1 2
S:S:L773 S:S:W742 6.83 11 Yes Yes 8 9 1 2
S:S:I777 S:S:L773 4.28 11 No Yes 8 8 1 1
S:S:L773 X:X:?3 8.58 11 Yes Yes 8 0 1 0
S:S:I777 X:X:?3 7.74 11 No Yes 8 0 1 0
S:S:T780 X:X:?3 4.57 0 No Yes 7 0 1 0
S:S:F814 S:S:W818 11.02 0 Yes Yes 9 9 2 1
S:S:V817 S:S:W818 6.13 0 No Yes 9 9 2 1
S:S:F821 S:S:W818 12.03 11 Yes Yes 9 9 1 1
S:S:A840 S:S:W818 5.19 0 No Yes 9 9 2 1
S:S:W818 X:X:?3 21.18 11 Yes Yes 9 0 1 0
S:S:F821 S:S:Y825 10.32 11 Yes No 9 9 1 1
S:S:E837 S:S:F821 4.66 11 Yes Yes 9 9 1 1
S:S:F821 X:X:?3 3.77 11 Yes Yes 9 0 1 0
S:S:E837 S:S:Y825 7.86 11 Yes No 9 9 1 1
S:S:Y825 X:X:?3 9.08 11 No Yes 9 0 1 0
S:S:E837 X:X:?3 11.29 11 Yes Yes 9 0 1 0
S:S:G685 X:X:?3 2.65 0 No Yes 8 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:N64 R:R:R66 3.62 0 No Yes 4 5 2 1
R:R:R66 R:R:R69 4.26 1 Yes Yes 5 8 1 2
R:R:R66 R:R:W70 12 1 Yes Yes 5 5 1 2
R:R:R66 W:W:?1 6.12 1 Yes Yes 5 0 1 2
R:R:R66 W:W:?2 13.98 1 Yes Yes 5 0 1 2
L:L:?1 R:R:R66 4.47 0 No Yes 0 5 0 1
R:R:R69 W:W:?2 13.98 1 Yes Yes 8 0 2 2
R:R:W70 W:W:?1 3.28 1 Yes Yes 5 0 2 2
R:R:W70 W:W:?2 7.86 1 Yes Yes 5 0 2 2
R:R:G273 R:R:S302 3.71 12 No Yes 4 5 2 1
R:R:G273 R:R:I305 3.53 12 No Yes 4 4 2 2
R:R:L304 R:R:S302 4.5 0 Yes Yes 2 5 2 1
R:R:I305 R:R:S302 3.1 12 Yes Yes 4 5 2 1
L:L:?1 R:R:S302 5.52 0 No Yes 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P39 R:R:W70 4.05 1 Yes Yes 6 5 2 1
R:R:P39 R:R:T145 6.99 1 Yes Yes 6 5 2 1
I:I:?2 R:R:P39 9.06 1 Yes Yes 0 6 2 2
R:R:N64 R:R:R66 3.62 0 No Yes 4 5 2 1
R:R:G67 R:R:N64 3.39 0 No No 4 4 2 2
R:R:R66 R:R:R69 4.26 1 Yes Yes 5 8 1 2
R:R:R66 R:R:W70 12 1 Yes Yes 5 5 1 1
R:R:R66 W:W:?1 6.12 1 Yes Yes 5 0 1 0
R:R:R66 W:W:?2 13.98 1 Yes Yes 5 0 1 2
L:L:?1 R:R:R66 4.47 0 No Yes 0 5 2 1
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:R69 W:W:?2 13.98 1 Yes Yes 8 0 2 2
R:R:T145 R:R:W70 3.64 1 Yes Yes 5 5 1 1
R:R:I416 R:R:W70 21.14 1 No Yes 4 5 2 1
R:R:S417 R:R:W70 4.94 1 No Yes 6 5 2 1
R:R:W70 W:W:?1 3.28 1 Yes Yes 5 0 1 0
R:R:W70 W:W:?2 7.86 1 Yes Yes 5 0 1 2
R:R:T145 R:R:Y167 6.24 1 Yes Yes 5 8 1 2
R:R:A168 R:R:T145 3.36 1 No Yes 5 5 1 1
R:R:T145 W:W:?1 5.3 1 Yes Yes 5 0 1 0
I:I:?2 R:R:T145 5.42 1 Yes Yes 0 5 2 1
R:R:S147 R:R:S171 4.89 1 No No 8 7 1 2
R:R:S147 R:R:Y218 3.82 1 No Yes 8 7 1 1
R:R:S147 W:W:?1 6.48 1 No Yes 8 0 1 0
R:R:A168 W:W:?1 3.4 1 No Yes 5 0 1 0
R:R:D190 R:R:S170 8.83 0 No No 8 7 2 1
R:R:S170 W:W:?1 8.64 0 No Yes 7 0 1 0
R:R:D190 R:R:Q193 7.83 0 No Yes 8 9 2 2
R:R:D190 R:R:Y218 5.75 0 No Yes 8 7 2 1
R:R:Q193 R:R:S296 4.33 1 Yes No 9 8 2 2
R:R:E297 R:R:Q193 3.82 0 No Yes 8 9 1 2
R:R:D216 R:R:Y218 3.45 0 No Yes 6 7 2 1
R:R:G219 R:R:Y218 4.35 0 No Yes 7 7 2 1
R:R:S296 R:R:Y218 5.09 1 No Yes 8 7 2 1
R:R:A298 R:R:Y218 4 1 No Yes 6 7 1 1
R:R:Y218 W:W:?1 19.39 1 Yes Yes 7 0 1 0
R:R:E297 R:R:L322 15.9 0 No No 8 4 1 2
R:R:E297 W:W:?1 6.67 0 No Yes 8 0 1 0
R:R:A298 W:W:?1 9.06 1 No Yes 6 0 1 0
R:R:I416 W:W:?2 8.21 1 No Yes 4 0 2 2
R:R:S417 W:W:?2 8.64 1 No Yes 6 0 2 2
R:R:G146 W:W:?1 2.46 0 No Yes 5 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F684 R:R:S664 5.28 3 Yes No 8 6 1 2
R:R:I841 R:R:S664 3.1 3 Yes No 9 6 2 2
R:R:E837 R:R:F668 15.16 3 Yes No 9 9 1 2
R:R:F668 R:R:I841 3.77 0 No Yes 9 9 2 2
R:R:P682 R:R:Q681 3.16 0 No Yes 5 9 2 1
R:R:Q681 R:R:W742 3.29 3 Yes Yes 9 9 1 2
R:R:E767 R:R:Q681 7.65 3 No Yes 7 9 2 1
R:R:L773 R:R:Q681 5.32 3 No Yes 8 9 2 1
R:R:E837 R:R:Q681 5.1 3 Yes Yes 9 9 1 1
R:R:Q681 W:W:?3 10.31 3 Yes Yes 9 0 1 0
R:R:F684 R:R:F688 7.5 3 Yes Yes 8 8 1 2
R:R:F684 R:R:I841 17.58 3 Yes Yes 8 9 1 2
R:R:F684 W:W:?3 12.27 3 Yes Yes 8 0 1 0
R:R:F688 R:R:F814 4.29 3 Yes Yes 8 9 2 2
R:R:T780 R:R:V689 4.76 0 No Yes 7 7 1 2
R:R:L773 R:R:W742 3.42 3 No Yes 8 9 2 2
R:R:E767 R:R:L773 5.3 3 No No 7 8 2 2
R:R:I777 W:W:?3 6.64 0 No Yes 8 0 1 0
R:R:T780 W:W:?3 4.57 0 No Yes 7 0 1 0
R:R:F814 R:R:W818 11.02 3 Yes Yes 9 9 2 1
R:R:A844 R:R:W818 3.89 0 No Yes 9 9 2 1
R:R:W818 W:W:?3 15.89 0 Yes Yes 9 0 1 0
R:R:E837 R:R:Y825 11.22 3 Yes No 9 9 1 1
R:R:Y825 W:W:?3 13.63 3 No Yes 9 0 1 0
R:R:E837 W:W:?3 11.29 3 Yes Yes 9 0 1 0
R:R:A840 R:R:W818 2.59 0 No Yes 9 9 2 1
R:R:G778 R:R:I777 1.76 0 No No 5 8 2 1
R:R:C781 R:R:I777 1.64 0 No No 7 8 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9AXF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.9
Number of Linked Nodes 1571
Number of Links 1910
Number of Hubs 295
Number of Links mediated by Hubs 1095
Number of Communities 60
Number of Nodes involved in Communities 465
Number of Links involved in Communities 643
Path Summary
Number Of Nodes in MetaPath 145
Number Of Links MetaPath 144
Number of Shortest Paths 8058824
Length Of Smallest Path 3
Average Path Length 47.7476
Length of Longest Path 94
Minimum Path Strength 1.22
Average Path Strength 6.39337
Maximum Path Strength 19.87
Minimum Path Correlation 0.7
Average Path Correlation 0.998872
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.5625
Average % Of Corr. Nodes 60.5443
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.9229
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • amino acid binding   • identical protein binding   • protein binding   • cation binding   • ion binding   • calcium ion binding   • metal ion binding   • small molecule binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • phosphoric ester hydrolase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • phospholipase C activity   • hydrolase activity   • phosphatidylinositol-4,5-bisphosphate phospholipase C activity   • catalytic activity   • phospholipase activity   • lipase activity   • transmembrane transporter binding   • cell adhesion molecule binding   • protein-containing complex binding   • integrin binding   • signaling receptor binding   • protein homodimerization activity   • protein dimerization activity   • kinase binding   • enzyme binding   • protein kinase binding   • biological regulation   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • regulation of biological process   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization
Gene OntologyBiological Process• biological regulation   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • regulation of biological process   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • developmental process   • multicellular organismal process   • epithelium development   • tube development   • branching morphogenesis of an epithelial tube   • morphogenesis of an epithelium   • tissue development   • tissue morphogenesis   • anatomical structure morphogenesis   • multicellular organism development   • tube morphogenesis   • morphogenesis of a branching structure   • anatomical structure development   • epithelial tube morphogenesis   • morphogenesis of a branching epithelium   • regulation of tube diameter   • system process   • regulation of tube size   • regulation of system process   • positive regulation of biological process   • positive regulation of vasoconstriction   • circulatory system process   • regulation of blood circulation   • vascular process in circulatory system   • regulation of vasoconstriction   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • blood vessel diameter maintenance   • vasoconstriction   • blood circulation   • regulation of anatomical structure size   • monoatomic ion transmembrane transport   • inorganic ion transmembrane transport   • inorganic anion transmembrane transport   • chloride transport   • transmembrane transport   • chloride transmembrane transport   • monoatomic anion transport   • monoatomic anion transmembrane transport   • cellular process   • inorganic anion transport   • regulation of biosynthetic process   • regulation of cellular process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • response to stimulus   • response to stress   • response to ischemia   • response to decreased oxygen levels   • cellular response to stimulus   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to chemical stimulus   • cellular response to stress   • response to hypoxia   • response to chemical   • response to oxygen levels   • response to abiotic stimulus   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • organic acid transport   • bile acid secretion   • organic anion transport   • monocarboxylic acid transport   • carboxylic acid transport   • secretion   • acid secretion   • response to peptide   • cellular response to peptide   • behavior   • chemosensory behavior   • signaling   • intracellular signal transduction   • cell communication   • JNK cascade   • intracellular signaling cassette   • MAPK cascade   • signal transduction   • cellular response to low-density lipoprotein particle stimulus   • response to endogenous stimulus   • response to lipoprotein particle   • response to nitrogen compound   • cellular response to lipoprotein particle stimulus   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • regulation of calcium ion import   • positive regulation of calcium ion transport   • positive regulation of calcium ion import   • positive regulation of transport   • positive regulation of monoatomic ion transport   • calcium ion import   • ossification   • connective tissue development   • adipose tissue development   • fat pad development   • animal organ development   • response to fibroblast growth factor   • response to growth factor   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • response to oxygen-containing compound   • cellular response to glucose stimulus   • intracellular glucose homeostasis   • cellular response to oxygen-containing compound   • response to hexose   • cellular response to carbohydrate stimulus   • response to monosaccharide   • response to carbohydrate   • response to glucose   • glucose homeostasis   • carbohydrate homeostasis   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • response to nutrient levels   • response to lipid   • response to nutrient   • response to vitamin   • cellular response to vitamin D   • cellular response to nutrient levels   • response to vitamin D   • cellular response to vitamin   • cellular response to lipid   • cellular response to nutrient   • cell population proliferation   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • vasodilation   • positive chemotaxis   • chemotaxis   • positive regulation of locomotion   • regulation of response to external stimulus   • positive regulation of positive chemotaxis   • response to external stimulus   • regulation of chemotaxis   • positive regulation of chemotaxis   • regulation of positive chemotaxis   • positive regulation of response to external stimulus   • taxis   • regulation of locomotion   • locomotion   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular response to endogenous stimulus   • response to hepatocyte growth factor   • cellular response to growth factor stimulus   • cellular response to hepatocyte growth factor stimulus   • protein localization   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • cellular macromolecule localization   • positive regulation of insulin secretion   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • regulation of protein secretion   • regulation of secretion   • positive regulation of protein localization   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • positive regulation of secretion   • amide transport   • signal release   • positive regulation of peptide secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • detection of stimulus   • response to metal ion   • detection of chemical stimulus   • detection of calcium ion   • response to calcium ion   • cell periphery   • presynapse   • cellular anatomical structure   • synapse   • cell junction   • membrane   • plasma membrane   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse
Gene OntologyCellular Component• cell periphery   • presynapse   • cellular anatomical structure   • synapse   • cell junction   • membrane   • plasma membrane   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse   • somatodendritic compartment   • cell body   • neuronal cell body   • apical part of cell   • apical plasma membrane   • cell surface   • axon   • neuron projection   • axon terminus   • plasma membrane bounded cell projection   • cell projection   • distal axon   • neuron projection terminus   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • D1 dopamine receptor binding   • molecular function activator activity   • enzyme activator activity   • cyclase activator activity   • adenylate cyclase activator activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to nitrogen compound   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • establishment of protein localization   • nitrogen compound transport   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • regulation of hormone secretion   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • midbody   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • ciliary basal body   • Golgi apparatus subcompartment   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • cell population proliferation   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Type 1 solute binding protein-like   • TNF receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Type 1 solute binding protein-like   • TNF receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeTCR
PDB ResiduesW:W:?1 X:X:?1
Environment DetailsOpen EMBL-EBI Page
CodeTCR
NameCYCLOMETHYLTRYPTOPHAN
Synonyms
Identifier
FormulaC12 H12 N2 O2
Molecular Weight216.236
SMILES
PubChem6920044
Formal Charge0
Total Atoms28
Total Chiral Atoms1
Total Bonds30
Total Aromatic Bonds10

CodePO4
PDB ResiduesW:W:?2 X:X:?2
Environment DetailsOpen EMBL-EBI Page
CodePO4
NamePhosphate ion
Synonyms
  • Phosphate
  • Phosphate ion
  • Orthophosphate
Identifier
FormulaO4 P
Molecular Weight94.971
SMILES
PubChem1061
Formal Charge-3
Total Atoms5
Total Chiral Atoms0
Total Bonds4
Total Aromatic Bonds0

CodeCA
PDB ResiduesI:I:?2 L:L:?1 I:I:?3 I:I:?5 I:I:?6 M:M:?1 I:I:?7
Environment DetailsOpen EMBL-EBI Page
CodeCA
NameCALCIUM ION
Synonyms
Identifier
FormulaCa
Molecular Weight40.078
SMILES
PubChem
Formal Charge2
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

Code9IG
PDB ResiduesW:W:?3 X:X:?3
Environment DetailsOpen EMBL-EBI Page
Code9IG
Name3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine
Synonyms
Identifier
FormulaC18 H22 Cl N O
Molecular Weight303.826
SMILES
PubChem158797
Formal Charge0
Total Atoms43
Total Chiral Atoms1
Total Bonds44
Total Aromatic Bonds12

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41180
Sequence
>9AXF_nogp_Chain_R
YGPDQRAQK KGDIILGGL FPIHFGVAA KDQDLKSRP ESVECIRYN 
FRGFRWLQA MIFAIEEIN SSPALLPNL TLGYRIFDT CNTVSKALE 
ATLSFVAQN KIDSLNLDE FCNCSEHIP STIAVVGAT GSGVSTAVA 
NLLGLFYIP QVSYASSSR LLSNKNQFK SFLRTIPND EHQATAMAD 
IIEYFRWNW VGTIAADDD YGRPGIEKF REEAEERDI CIDFSELIS 
QYSDEEEIQ HVVEVIQNS TAKVIVVFS SGPDLEPLI KEIVRRNIT 
GKIWLASEA WASSSLIAM PQYFHVVGG TIGFALKAG QIPGFREFL 
KKVHPRKSV HNGFAKEFW EETFNCHLR PLCTGDENI SSVETPYID 
YTHLRISYN VYLAVYSIA HALQDIYTC LPGRGLFTN GSCADIKKV 
EAWQVLKHL RHLNFTNNM GEQVTFDEC GDLVGNYSI INWHLSPED 
GSIVFKEVG YYNVYAKKG ERLFINEEK ILWSGFSRE VPFSNCSRD 
CLAGTRKGI IEGEPTCCF ECVECPDGE YSDETDASA CNKCPDDFW 
SNENHTSCI AKEIEFLSW TEPFGIALT LFAVLGIFL TAFVLGVFI 
KFRNTPIVK ATNRELSYL LLFSLLCCF SSSLFFIGE PQDWTCRLR 
QPAFGISFV LCISCILVK TNRVLLVFE AKIPTSFHR KWWGLNLQF 
LLVFLCTFM QIVICVIWL YTAPPSSYR NQELEDEII FITCHEGSL 
MALGFLIGY TCLLAAICF FFAFKSRKL PENFNEAKF ITFSMLIFF 
IVWISFIPA YASTYGKFV SAVEVIAIL AASFGLLAC IFFNKIYII 
LFKPSRNTI EEVRCSTAA HAFK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP41180
Sequence
>9AXF_nogp_Chain_S
YGPDQRAQK KGDIILGGL FPIHFGVAA KDQDLKSRP ESVECIRYN 
FRGFRWLQA MIFAIEEIN SSPALLPNL TLGYRIFDT CNTVSKALE 
ATLSFVAQN KIDSLNLDE FCNCSEHIP STIAVVGAT GSGVSTAVA 
NLLGLFYIP QVSYASSSR LLSNKNQFK SFLRTIPND EHQATAMAD 
IIEYFRWNW VGTIAADDD YGRPGIEKF REEAEERDI CIDFSELIS 
QYSDEEEIQ HVVEVIQNS TAKVIVVFS SGPDLEPLI KEIVRRNIT 
GKIWLASEA WASSSLIAM PQYFHVVGG TIGFALKAG QIPGFREFL 
KKVHPRKSV HNGFAKEFW EETFNCHLR PLCTGDENI SSVETPYID 
YTHLRISYN VYLAVYSIA HALQDIYTC LPGRGLFTN GSCADIKKV 
EAWQVLKHL RHLNFTNNM GEQVTFDEC GDLVGNYSI INWHLSPED 
GSIVFKEVG YYNVYAKKG ERLFINEEK ILWSGFSRE VPFSNCSRD 
CLAGTRKGI IEGEPTCCF ECVECPDGE YSDETDASA CNKCPDDFW 
SNENHTSCI AKEIEFLSW TEPFGIALT LFAVLGIFL TAFVLGVFI 
KFRNTPIVK ATNRELSYL LLFSLLCCF SSSLFFIGE PQDWTCRLR 
QPAFGISFV LCISCILVK TNLQFLLVF LCTFMQIVI CVIWLYTAP 
PSSYRNQEL EDEIIFITC HEGSLMALG FLIGYTCLL AAICFFFAF 
KSRKLPENF NEAKFITFS MLIFFIVWI SFIPAYAST YGKFVSAVE 
VIAILAASF GLLACIFFN KIYIILFK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9C2FCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Tryptophan; '6218; PO4-2.82024-10-0210.1126/science.ado1868
9C1PCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan; '6218; PO4-2.82024-10-0210.1126/science.ado1868
9AXFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.52024-04-1710.1038/s41586-024-07331-1
9AXF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.52024-04-1710.1038/s41586-024-07331-1
9ASBCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.42024-04-1710.1038/s41586-024-07331-1
9ASB (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.42024-04-1710.1038/s41586-024-07331-1
9AVGCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs)/β1/γ23.62024-04-1710.1038/s41586-024-07331-1
9AVG (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-1710.1038/s41586-024-07331-1
9AYFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4Gi1/β1/γ23.62024-04-1710.1038/s41586-024-07331-1
9AYF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-1710.1038/s41586-024-07331-1
9AVLCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4Gi3/β2/γ23.82024-04-1710.1038/s41586-024-07331-1
9AVL (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.82024-04-1710.1038/s41586-024-07331-1
8SZFCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-2.82024-02-0710.1038/s41586-024-07055-2
8SZGCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWchim(NtGi1-Gq)/β1/γ23.62024-02-0710.1038/s41586-024-07055-2
8SZG (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW3.62024-02-0710.1038/s41586-024-07055-2
8SZHCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWGi1/β1/γ23.12024-02-0710.1038/s41586-024-07055-2
8SZH (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW3.12024-02-0710.1038/s41586-024-07055-2
8SZICIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWGi3/β1/γ23.52024-02-0710.1038/s41586-024-07055-2
8SZI (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW3.52024-02-0710.1038/s41586-024-07055-2
8WPGCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca-2.72023-11-2210.1038/s41422-023-00892-2
8WPUCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(NtGi2L-Gs-CtGq)/β1/γ23.12023-11-2210.1038/s41422-023-00892-2
8WPU (No Gprot) CIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca3.12023-11-2210.1038/s41422-023-00892-2
7SINCIonCalcium SensingCaSHomo sapiens-NPS-2143-5.92022-01-1910.1073/pnas.2115849118
7SIMCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-2.72022-01-1910.1073/pnas.2115849118
7SILCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-2.72022-01-1910.1073/pnas.2115849118
7E6UCIonCalcium SensingCaSHomo sapiens---62021-09-2210.7554/eLife.68578
7E6TCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-32021-09-2210.7554/eLife.68578
7M3JCIonCalcium SensingCaSHomo sapiens-NPS-2143; PO4-4.12021-06-3010.1038/s41586-021-03691-0
7M3GCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4-2.52021-06-3010.1038/s41586-021-03691-0
7M3FCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4-2.82021-06-3010.1038/s41586-021-03691-0
7M3ECIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; NPS-2143-3.22021-06-3010.1038/s41586-021-03691-0
7DD7CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; Evocalcet-3.22021-06-1610.1126/sciadv.abg1483
7DD6CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan-3.22021-06-1610.1126/sciadv.abg1483
7DD5CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; NPS-2143-3.22021-06-1610.1126/sciadv.abg1483
7DTWCIonCalcium SensingCaSHomo sapiens---4.52021-03-1010.1038/s41422-021-00474-0
7DTVCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan-3.52021-03-1010.1038/s41422-021-00474-0
7DTUCIonCalcium SensingCaSHomo sapiens-Tryptophan-4.42021-03-1010.1038/s41422-021-00474-0
7DTTCIonCalcium SensingCaSHomo sapiensCaCa-3.82021-03-1010.1038/s41422-021-00474-0




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9AXF_nogp.zip



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You can also  read or  download a guide explaining the meaning of all files and numerical data.