CodeTCR
NameCYCLOMETHYLTRYPTOPHAN
Synonyms
Identifier(3S)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
FormulaC12 H12 N2 O2
Molecular Weight216.236
SMILESc1ccc2c(c1)c3c([nH]2)CN[C@@H](C3)C(=O)O
PubChem449440
Formal Charge0
Total Atoms28
Total Chiral Atoms1
Total Bonds30
Total Aromatic Bonds10
Networks5
 missing image

This ligand is also present in the following 5 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7E6T C Ion Calcium-sensing CaS Homo sapiens Ca Ca; Ca; Cyclomethyltryptophan; PO4 - 3 2021-09-22 10.7554/eLife.68578

A 2D representation of the interactions of TCR in 7E6T
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P39 R:R:W70 5.4 1 Yes Yes 6 5 2 2
R:R:P39 R:R:T145 5.25 1 Yes Yes 6 5 2 1
R:R:P39 R:R:Y167 2.78 1 Yes Yes 6 8 2 2
I:I:?904 R:R:P39 6.03 1 Yes Yes 0 6 2 2
R:R:R66 R:R:R69 7.46 1 Yes No 5 8 1 2
R:R:R66 R:R:W70 7 1 Yes Yes 5 5 1 2
R:R:I416 R:R:R66 2.51 1 Yes Yes 4 5 1 1
R:R:R66 W:W:?907 5.96 1 Yes Yes 5 0 1 0
R:R:R66 W:W:?901 6.99 1 Yes Yes 5 0 1 2
R:R:R69 W:W:?901 16.77 1 No Yes 8 0 2 2
R:R:T145 R:R:W70 2.43 1 Yes Yes 5 5 1 2
R:R:W70 R:R:Y167 4.82 1 Yes Yes 5 8 2 2
R:R:I416 R:R:W70 17.62 1 Yes Yes 4 5 1 2
R:R:W70 W:W:?901 9.17 1 Yes Yes 5 0 2 2
R:R:T145 R:R:Y167 6.24 1 Yes Yes 5 8 1 2
R:R:A168 R:R:T145 3.36 1 No Yes 5 5 2 1
I:I:?904 R:R:T145 2.71 1 Yes Yes 0 5 2 1
R:R:T145 W:W:?907 5.17 1 Yes Yes 5 0 1 0
R:R:S147 R:R:S171 6.52 1 No No 8 7 1 2
R:R:S147 R:R:Y218 5.09 1 No Yes 8 7 1 1
R:R:S147 W:W:?907 6.32 1 No Yes 8 0 1 0
R:R:A168 R:R:Y167 2.67 1 No Yes 5 8 2 2
R:R:I416 R:R:Y167 3.63 1 Yes Yes 4 8 1 2
R:R:D190 R:R:Q193 5.22 1 Yes Yes 8 9 2 2
R:R:D190 R:R:Y218 4.6 1 Yes Yes 8 7 2 1
R:R:Q193 R:R:S296 2.89 1 Yes No 9 8 2 2
R:R:E297 R:R:Q193 3.82 0 No Yes 8 9 1 2
R:R:D216 R:R:Y218 3.45 0 No Yes 6 7 2 1
R:R:S296 R:R:Y218 5.09 0 No Yes 8 7 2 1
R:R:A298 R:R:Y218 4 1 No Yes 6 7 1 1
R:R:Y218 W:W:?907 19.72 1 Yes Yes 7 0 1 0
R:R:E297 R:R:L322 10.6 0 No No 8 4 1 2
R:R:E297 W:W:?907 6.5 0 No Yes 8 0 1 0
R:R:A298 W:W:?907 3.31 1 No Yes 6 0 1 0
R:R:I416 W:W:?907 4 1 Yes Yes 4 0 1 0
R:R:I416 W:W:?901 11.49 1 Yes Yes 4 0 1 2
R:R:N64 R:R:R66 2.41 0 No Yes 4 5 2 1
R:R:G146 R:R:T145 1.82 0 No Yes 5 5 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.28
Average Nodes In Shell23.00
Average Hubs In Shell12.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TCR in 7E6T
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:R66 S:S:R69 4.26 2 Yes Yes 5 8 1 2
S:S:R66 S:S:W70 16.99 2 Yes Yes 5 5 1 2
S:S:I416 S:S:R66 3.76 2 Yes Yes 4 5 2 1
S:S:R66 X:X:?907 2.55 2 Yes Yes 5 0 1 0
S:S:R66 X:X:?901 20.96 2 Yes Yes 5 0 1 2
S:S:R69 X:X:?901 8.38 2 Yes Yes 8 0 2 2
S:S:I416 S:S:W70 19.97 2 Yes Yes 4 5 2 2
S:S:W70 X:X:?901 7.86 2 Yes Yes 5 0 2 2
S:S:S147 S:S:S171 3.26 2 No No 8 7 1 2
S:S:S147 S:S:Y218 3.82 2 No Yes 8 7 1 1
S:S:S147 X:X:?907 6.32 2 No Yes 8 0 1 0
S:S:I187 S:S:S170 4.64 2 Yes Yes 6 7 2 1
S:S:D190 S:S:S170 7.36 2 No Yes 8 7 2 1
S:S:S170 S:S:Y218 2.54 2 Yes Yes 7 7 1 1
M:M:?902 S:S:S170 5.51 2 Yes Yes 0 7 2 1
S:S:S170 X:X:?907 4.21 2 Yes Yes 7 0 1 0
S:S:I187 S:S:L322 2.85 2 Yes Yes 6 4 2 2
M:M:?902 S:S:I187 5.24 2 Yes Yes 0 6 2 2
S:S:D190 S:S:Y218 6.9 2 No Yes 8 7 2 1
M:M:?902 S:S:D190 2.49 2 Yes No 0 8 2 2
S:S:Q193 S:S:S296 7.22 0 Yes No 9 8 2 2
S:S:E297 S:S:Q193 3.82 0 No Yes 8 9 1 2
M:M:?902 S:S:Q193 2.44 2 Yes Yes 0 9 2 2
S:S:S296 S:S:Y218 3.82 0 No Yes 8 7 2 1
S:S:A298 S:S:Y218 4 2 No Yes 6 7 1 1
S:S:Y218 X:X:?907 18.9 2 Yes Yes 7 0 1 0
S:S:E297 S:S:L322 7.95 0 No Yes 8 4 1 2
S:S:E297 X:X:?907 6.5 0 No Yes 8 0 1 0
S:S:A298 X:X:?907 5.52 2 No Yes 6 0 1 0
S:S:I416 X:X:?901 6.57 2 Yes Yes 4 0 2 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.33
Average Nodes In Shell18.00
Average Hubs In Shell12.00
Average Links In Shell30.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SIL C Ion Calcium-sensing CaS Homo sapiens Ca Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 - 2.7 2022-01-19 10.1073/pnas.2115849118

A 2D representation of the interactions of TCR in 7SIL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P39 R:R:W70 5.4 1 Yes Yes 6 5 2 1
R:R:P39 R:R:T145 10.49 1 Yes Yes 6 5 2 1
I:I:?2 R:R:P39 9.05 1 No Yes 0 6 2 2
R:R:R66 R:R:R69 6.4 1 Yes Yes 5 8 1 2
R:R:R66 R:R:W70 13 1 Yes Yes 5 5 1 1
R:R:R66 W:W:?2 5.96 1 Yes Yes 5 0 1 0
R:R:R66 W:W:?3 19.56 1 Yes Yes 5 0 1 2
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:R69 R:R:S417 6.59 1 Yes Yes 8 6 2 2
R:R:R69 W:W:?3 13.97 1 Yes Yes 8 0 2 2
R:R:T145 R:R:W70 6.06 1 Yes Yes 5 5 1 1
R:R:W70 R:R:Y167 4.82 1 Yes Yes 5 8 1 2
R:R:I416 R:R:W70 21.14 1 Yes Yes 4 5 1 1
R:R:S417 R:R:W70 4.94 1 Yes Yes 6 5 2 1
R:R:W70 W:W:?2 6.39 1 Yes Yes 5 0 1 0
R:R:W70 W:W:?3 9.17 1 Yes Yes 5 0 1 2
R:R:T145 R:R:Y167 9.99 1 Yes Yes 5 8 1 2
R:R:A168 R:R:T145 3.36 1 No Yes 5 5 1 1
R:R:T145 W:W:?2 5.17 1 Yes Yes 5 0 1 0
I:I:?2 R:R:T145 5.41 1 No Yes 0 5 2 1
R:R:S147 R:R:S169 3.26 1 Yes No 8 8 1 2
R:R:S147 R:R:S171 3.26 1 Yes No 8 7 1 2
R:R:S147 R:R:Y218 3.82 1 Yes Yes 8 7 1 1
R:R:S147 W:W:?2 6.32 1 Yes Yes 8 0 1 0
R:R:A168 R:R:I416 3.25 1 No Yes 5 4 1 1
R:R:A168 W:W:?2 3.31 1 No Yes 5 0 1 0
R:R:I187 R:R:S170 6.19 0 Yes No 6 7 2 1
R:R:D190 R:R:S170 8.83 0 No No 8 7 2 1
R:R:S170 W:W:?2 7.37 0 No Yes 7 0 1 0
R:R:I187 R:R:L322 4.28 0 Yes No 6 4 2 2
R:R:D190 R:R:Y218 8.05 0 No Yes 8 7 2 1
R:R:E297 R:R:Q193 3.82 1 Yes No 8 9 1 2
R:R:D216 R:R:Y218 3.45 1 No Yes 6 7 2 1
R:R:S296 R:R:Y218 6.36 0 No Yes 8 7 2 1
R:R:A298 R:R:Y218 6.67 1 No Yes 6 7 1 1
R:R:Y218 W:W:?2 21.37 1 Yes Yes 7 0 1 0
R:R:E297 R:R:L322 13.25 1 Yes No 8 4 1 2
R:R:E297 R:R:I416 4.1 1 Yes Yes 8 4 1 1
R:R:E297 W:W:?2 11.15 1 Yes Yes 8 0 1 0
R:R:A298 W:W:?2 8.84 1 No Yes 6 0 1 0
R:R:I416 W:W:?2 4 1 Yes Yes 4 0 1 0
R:R:I416 W:W:?3 9.85 1 Yes Yes 4 0 1 2
R:R:S417 W:W:?3 6.91 1 Yes Yes 6 0 2 2
R:R:G219 R:R:Y218 2.9 0 No Yes 7 7 2 1
R:R:G146 W:W:?2 2.4 0 No Yes 5 0 1 0
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.48
Average Nodes In Shell28.00
Average Hubs In Shell14.00
Average Links In Shell45.00
Average Links Mediated by Hubs In Shell44.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TCR in 7SIL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:P39 S:S:W70 5.4 2 Yes Yes 6 5 2 1
S:S:P39 S:S:T145 10.49 2 Yes Yes 6 5 2 1
I:I:?6 S:S:P39 9.05 2 No Yes 0 6 2 2
S:S:R66 S:S:R69 6.4 2 Yes Yes 5 8 1 2
S:S:R66 S:S:W70 13 2 Yes Yes 5 5 1 1
S:S:R66 X:X:?2 5.96 2 Yes Yes 5 0 1 0
S:S:R66 X:X:?3 19.56 2 Yes Yes 5 0 1 2
S:S:G67 S:S:W70 5.63 0 No Yes 4 5 2 1
S:S:R69 S:S:S417 6.59 2 Yes Yes 8 6 2 2
S:S:R69 X:X:?3 13.97 2 Yes Yes 8 0 2 2
S:S:T145 S:S:W70 6.06 2 Yes Yes 5 5 1 1
S:S:W70 S:S:Y167 4.82 2 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 21.14 2 Yes Yes 4 5 1 1
S:S:S417 S:S:W70 4.94 2 Yes Yes 6 5 2 1
S:S:W70 X:X:?2 6.39 2 Yes Yes 5 0 1 0
S:S:W70 X:X:?3 9.17 2 Yes Yes 5 0 1 2
S:S:T145 S:S:Y167 9.99 2 Yes Yes 5 8 1 2
S:S:A168 S:S:T145 3.36 2 No Yes 5 5 1 1
S:S:T145 X:X:?2 5.17 2 Yes Yes 5 0 1 0
I:I:?6 S:S:T145 5.41 2 No Yes 0 5 2 1
S:S:S147 S:S:S169 3.26 2 Yes No 8 8 1 2
S:S:S147 S:S:S171 3.26 2 Yes No 8 7 1 2
S:S:S147 S:S:Y218 3.82 2 Yes Yes 8 7 1 1
S:S:S147 X:X:?2 6.32 2 Yes Yes 8 0 1 0
S:S:A168 S:S:I416 3.25 2 No Yes 5 4 1 1
S:S:A168 X:X:?2 3.31 2 No Yes 5 0 1 0
S:S:I187 S:S:S170 6.19 0 Yes No 6 7 2 1
S:S:D190 S:S:S170 8.83 0 No No 8 7 2 1
S:S:S170 X:X:?2 7.37 0 No Yes 7 0 1 0
S:S:I187 S:S:L322 4.28 0 Yes No 6 4 2 2
S:S:D190 S:S:Q193 3.92 0 No Yes 8 9 2 2
S:S:D190 S:S:Y218 8.05 0 No Yes 8 7 2 1
S:S:Q193 S:S:S296 4.33 0 Yes No 9 8 2 2
S:S:E297 S:S:Q193 3.82 2 Yes Yes 8 9 1 2
S:S:D216 S:S:Y218 3.45 0 No Yes 6 7 2 1
S:S:S296 S:S:Y218 6.36 0 No Yes 8 7 2 1
S:S:A298 S:S:Y218 6.67 2 No Yes 6 7 1 1
S:S:Y218 X:X:?2 21.37 2 Yes Yes 7 0 1 0
S:S:E297 S:S:L322 13.25 2 Yes No 8 4 1 2
S:S:E297 S:S:I416 5.47 2 Yes Yes 8 4 1 1
S:S:E297 X:X:?2 11.15 2 Yes Yes 8 0 1 0
S:S:A298 X:X:?2 8.84 2 No Yes 6 0 1 0
S:S:I416 X:X:?2 4 2 Yes Yes 4 0 1 0
S:S:I416 X:X:?3 9.85 2 Yes Yes 4 0 1 2
S:S:S417 X:X:?3 6.91 2 Yes Yes 6 0 2 2
S:S:G219 S:S:Y218 2.9 0 No Yes 7 7 2 1
S:S:G146 X:X:?2 2.4 0 No Yes 5 0 1 0
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.48
Average Nodes In Shell28.00
Average Hubs In Shell15.00
Average Links In Shell47.00
Average Links Mediated by Hubs In Shell46.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SIM C Ion Calcium-sensing CaS Homo sapiens Ca Ca; Ca; Cyclomethyltryptophan; PO4 - 2.7 2022-01-19 10.1073/pnas.2115849118

A 2D representation of the interactions of TCR in 7SIM
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P39 R:R:W70 5.4 1 Yes Yes 6 5 2 1
R:R:P39 R:R:T145 10.49 1 Yes Yes 6 5 2 1
I:I:?2 R:R:P39 9.05 1 No Yes 0 6 2 2
R:R:R66 R:R:R69 5.33 1 Yes Yes 5 8 1 2
R:R:R66 R:R:W70 12 1 Yes Yes 5 5 1 1
R:R:R66 W:W:?1 5.96 1 Yes Yes 5 0 1 0
R:R:R66 W:W:?2 18.17 1 Yes Yes 5 0 1 2
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:R69 R:R:S417 6.59 1 Yes Yes 8 6 2 2
R:R:R69 W:W:?2 12.58 1 Yes Yes 8 0 2 2
R:R:T145 R:R:W70 6.06 1 Yes Yes 5 5 1 1
R:R:W70 R:R:Y167 6.75 1 Yes Yes 5 8 1 2
R:R:I416 R:R:W70 21.14 1 Yes Yes 4 5 1 1
R:R:S417 R:R:W70 4.94 1 Yes Yes 6 5 2 1
R:R:W70 W:W:?1 5.59 1 Yes Yes 5 0 1 0
R:R:W70 W:W:?2 9.17 1 Yes Yes 5 0 1 2
R:R:T145 R:R:Y167 7.49 1 Yes Yes 5 8 1 2
R:R:T145 W:W:?1 5.17 1 Yes Yes 5 0 1 0
I:I:?2 R:R:T145 5.41 1 No Yes 0 5 2 1
R:R:S147 R:R:S169 4.89 1 Yes No 8 8 1 2
R:R:S147 R:R:S171 6.52 1 Yes No 8 7 1 2
R:R:S147 R:R:Y218 3.82 1 Yes Yes 8 7 1 1
R:R:S147 W:W:?1 6.32 1 Yes Yes 8 0 1 0
R:R:I416 R:R:Y167 4.84 1 Yes Yes 4 8 1 2
R:R:A168 W:W:?1 4.42 0 No Yes 5 0 1 0
R:R:I187 R:R:S170 6.19 0 Yes No 6 7 2 1
R:R:D190 R:R:S170 8.83 1 Yes No 8 7 2 1
R:R:S170 W:W:?1 8.42 0 No Yes 7 0 1 0
R:R:I187 R:R:L322 4.28 0 Yes No 6 4 2 2
R:R:D190 R:R:Q193 3.92 1 Yes Yes 8 9 2 2
R:R:D190 R:R:Y218 8.05 1 Yes Yes 8 7 2 1
R:R:D190 R:R:F270 9.55 1 Yes Yes 8 7 2 2
R:R:E297 R:R:Q193 3.82 1 Yes Yes 8 9 1 2
R:R:D216 R:R:Y218 3.45 1 No Yes 6 7 2 1
R:R:G219 R:R:Y218 4.35 0 No Yes 7 7 2 1
R:R:F270 R:R:Y218 15.47 1 Yes Yes 7 7 2 1
R:R:S296 R:R:Y218 6.36 1 No Yes 8 7 2 1
R:R:A298 R:R:Y218 5.34 1 No Yes 6 7 1 1
R:R:Y218 W:W:?1 20.55 1 Yes Yes 7 0 1 0
R:R:F270 R:R:S296 13.21 1 Yes No 7 8 2 2
R:R:E297 R:R:L322 10.6 1 Yes No 8 4 1 2
R:R:E297 R:R:I416 4.1 1 Yes Yes 8 4 1 1
R:R:E297 W:W:?1 11.15 1 Yes Yes 8 0 1 0
R:R:A298 W:W:?1 8.84 1 No Yes 6 0 1 0
R:R:I416 W:W:?1 4 1 Yes Yes 4 0 1 0
R:R:I416 W:W:?2 9.85 1 Yes Yes 4 0 1 2
R:R:S417 W:W:?2 6.91 1 Yes Yes 6 0 2 2
R:R:G146 W:W:?1 2.4 0 No Yes 5 0 1 0
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.53
Average Nodes In Shell29.00
Average Hubs In Shell17.00
Average Links In Shell48.00
Average Links Mediated by Hubs In Shell48.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TCR in 7SIM
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:P39 S:S:W70 5.4 2 Yes Yes 6 5 2 1
S:S:P39 S:S:T145 10.49 2 Yes Yes 6 5 2 1
I:I:?6 S:S:P39 9.05 2 No Yes 0 6 2 2
S:S:R66 S:S:R69 5.33 2 Yes Yes 5 8 1 2
S:S:R66 S:S:W70 12 2 Yes Yes 5 5 1 1
S:S:R66 X:X:?1 5.96 2 Yes Yes 5 0 1 0
S:S:R66 X:X:?2 18.17 2 Yes Yes 5 0 1 2
S:S:G67 S:S:W70 5.63 0 No Yes 4 5 2 1
S:S:R69 S:S:S417 6.59 2 Yes Yes 8 6 2 2
S:S:R69 X:X:?2 12.58 2 Yes Yes 8 0 2 2
S:S:T145 S:S:W70 6.06 2 Yes Yes 5 5 1 1
S:S:W70 S:S:Y167 6.75 2 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 21.14 2 Yes Yes 4 5 1 1
S:S:S417 S:S:W70 4.94 2 Yes Yes 6 5 2 1
S:S:W70 X:X:?1 5.59 2 Yes Yes 5 0 1 0
S:S:W70 X:X:?2 9.17 2 Yes Yes 5 0 1 2
S:S:T145 S:S:Y167 9.99 2 Yes Yes 5 8 1 2
S:S:T145 X:X:?1 4.13 2 Yes Yes 5 0 1 0
I:I:?6 S:S:T145 5.41 2 No Yes 0 5 2 1
S:S:S147 S:S:S169 4.89 2 Yes No 8 8 1 2
S:S:S147 S:S:S171 6.52 2 Yes No 8 7 1 2
S:S:S147 S:S:Y218 3.82 2 Yes Yes 8 7 1 1
S:S:S147 X:X:?1 6.32 2 Yes Yes 8 0 1 0
S:S:I416 S:S:Y167 3.63 2 Yes Yes 4 8 1 2
S:S:I187 S:S:S170 6.19 0 Yes No 6 7 2 1
S:S:D190 S:S:S170 8.83 2 Yes No 8 7 2 1
S:S:S170 X:X:?1 8.42 0 No Yes 7 0 1 0
S:S:I187 S:S:L322 4.28 0 Yes No 6 4 2 2
S:S:D190 S:S:Q193 3.92 2 Yes Yes 8 9 2 2
S:S:D190 S:S:Y218 8.05 2 Yes Yes 8 7 2 1
S:S:D190 S:S:F270 8.36 2 Yes Yes 8 7 2 2
S:S:Q193 S:S:S296 4.33 2 Yes No 9 8 2 2
S:S:E297 S:S:Q193 5.1 2 Yes Yes 8 9 1 2
S:S:D216 S:S:Y218 3.45 0 No Yes 6 7 2 1
S:S:G219 S:S:Y218 4.35 0 No Yes 7 7 2 1
S:S:F270 S:S:Y218 15.47 2 Yes Yes 7 7 2 1
S:S:S296 S:S:Y218 6.36 2 No Yes 8 7 2 1
S:S:A298 S:S:Y218 5.34 2 No Yes 6 7 1 1
S:S:Y218 X:X:?1 20.55 2 Yes Yes 7 0 1 0
S:S:F270 S:S:S296 13.21 2 Yes No 7 8 2 2
S:S:E297 S:S:L322 10.6 2 Yes No 8 4 1 2
S:S:E297 S:S:I416 4.1 2 Yes Yes 8 4 1 1
S:S:E297 X:X:?1 13.01 2 Yes Yes 8 0 1 0
S:S:A298 X:X:?1 8.84 2 No Yes 6 0 1 0
S:S:I416 X:X:?1 4 2 Yes Yes 4 0 1 0
S:S:I416 X:X:?2 8.21 2 Yes Yes 4 0 1 2
S:S:S417 X:X:?2 6.91 2 Yes Yes 6 0 2 2
S:S:A168 S:S:T145 3.36 0 No Yes 5 5 2 1
S:S:G146 X:X:?1 2.4 0 No Yes 5 0 1 0
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.92
Average Nodes In Shell29.00
Average Hubs In Shell17.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell49.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9AXF C Ion Calcium-sensing CaS Homo Sapiens Ca Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 3.5 2024-04-17 10.1038/s41586-024-07331-1

A 2D representation of the interactions of TCR in 9AXF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F38 R:R:W70 2 1 Yes Yes 7 5 2 1
R:R:F38 R:R:Y167 11.35 1 Yes Yes 7 8 2 2
R:R:N64 R:R:P39 1.63 0 Yes Yes 4 6 2 2
R:R:P39 R:R:W70 4.05 1 Yes Yes 6 5 2 1
R:R:P39 R:R:T145 6.99 1 Yes Yes 6 5 2 1
I:I:?2 R:R:P39 9.05 1 Yes Yes 0 6 2 2
R:R:N64 R:R:R66 3.62 0 Yes Yes 4 5 2 1
R:R:G67 R:R:N64 3.39 0 No Yes 4 4 2 2
R:R:R66 R:R:R69 4.26 1 Yes Yes 5 8 1 2
R:R:R66 R:R:W70 12 1 Yes Yes 5 5 1 1
R:R:R66 W:W:?1 5.96 1 Yes Yes 5 0 1 0
R:R:R66 W:W:?2 13.97 1 Yes Yes 5 0 1 2
L:L:?1 R:R:R66 4.46 0 No Yes 0 5 2 1
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:R69 R:R:S417 2.64 1 Yes Yes 8 6 2 2
R:R:R69 W:W:?2 13.97 1 Yes Yes 8 0 2 2
R:R:T145 R:R:W70 3.64 1 Yes Yes 5 5 1 1
R:R:W70 R:R:Y167 1.93 1 Yes Yes 5 8 1 2
R:R:I416 R:R:W70 21.14 1 Yes Yes 4 5 1 1
R:R:S417 R:R:W70 4.94 1 Yes Yes 6 5 2 1
R:R:W70 W:W:?1 3.19 1 Yes Yes 5 0 1 0
R:R:W70 W:W:?2 7.86 1 Yes Yes 5 0 1 2
R:R:G146 R:R:T145 1.82 1 Yes Yes 5 5 1 1
R:R:T145 R:R:Y167 6.24 1 Yes Yes 5 8 1 2
R:R:A168 R:R:T145 3.36 1 Yes Yes 5 5 1 1
R:R:T145 W:W:?1 5.17 1 Yes Yes 5 0 1 0
I:I:?2 R:R:T145 5.41 1 Yes Yes 0 5 2 1
R:R:G146 R:R:V149 1.84 1 Yes Yes 5 4 1 2
R:R:G146 R:R:S169 1.86 1 Yes Yes 5 8 1 2
R:R:G146 W:W:?1 2.4 1 Yes Yes 5 0 1 0
R:R:S147 R:R:S169 1.63 1 Yes Yes 8 8 1 2
R:R:S147 R:R:S171 4.89 1 Yes Yes 8 7 1 2
R:R:L174 R:R:S147 1.5 1 Yes Yes 7 8 2 1
R:R:S147 R:R:Y218 3.82 1 Yes Yes 8 7 1 1
R:R:S147 W:W:?1 6.32 1 Yes Yes 8 0 1 0
I:I:?2 R:R:V149 2.74 1 Yes Yes 0 4 2 2
R:R:A168 R:R:Y167 2.67 1 Yes Yes 5 8 1 2
R:R:A168 R:R:I416 1.62 1 Yes Yes 5 4 1 1
R:R:A168 W:W:?1 3.31 1 Yes Yes 5 0 1 0
R:R:L174 R:R:S169 1.5 1 Yes Yes 7 8 2 2
R:R:I187 R:R:S170 1.55 1 Yes Yes 6 7 2 1
R:R:D190 R:R:S170 8.83 1 No Yes 8 7 2 1
R:R:S170 R:R:Y218 2.54 1 Yes Yes 7 7 1 1
R:R:S170 W:W:?1 8.42 1 Yes Yes 7 0 1 0
R:R:L174 R:R:S171 1.5 1 Yes Yes 7 7 2 2
R:R:I187 R:R:L322 5.71 1 Yes Yes 6 4 2 2
R:R:D190 R:R:Q193 7.83 1 No Yes 8 9 2 2
R:R:D190 R:R:Y218 5.75 1 No Yes 8 7 2 1
R:R:F270 R:R:Q193 5.86 1 Yes Yes 7 9 2 2
R:R:Q193 R:R:S296 4.33 1 Yes Yes 9 8 2 2
R:R:E297 R:R:Q193 3.82 0 No Yes 8 9 1 2
R:R:D216 R:R:Y218 3.45 1 No Yes 6 7 2 1
R:R:D216 R:R:G219 1.68 1 No Yes 6 7 2 2
R:R:G219 R:R:Y218 4.35 1 Yes Yes 7 7 2 1
R:R:F270 R:R:Y218 2.06 1 Yes Yes 7 7 2 1
R:R:S296 R:R:Y218 5.09 1 Yes Yes 8 7 2 1
R:R:A298 R:R:Y218 4 1 No Yes 6 7 1 1
R:R:Y218 W:W:?1 18.9 1 Yes Yes 7 0 1 0
R:R:F270 R:R:G219 1.51 1 Yes Yes 7 7 2 2
R:R:F270 R:R:S296 6.61 1 Yes Yes 7 8 2 2
R:R:A298 R:R:S272 1.71 1 No Yes 6 5 1 2
R:R:E297 R:R:L322 15.9 0 No Yes 8 4 1 2
R:R:E297 W:W:?1 6.5 0 No Yes 8 0 1 0
R:R:A298 W:W:?1 8.84 1 No Yes 6 0 1 0
R:R:I416 W:W:?1 2 1 Yes Yes 4 0 1 0
R:R:I416 W:W:?2 8.21 1 Yes Yes 4 0 1 2
R:R:S417 W:W:?2 8.64 1 Yes Yes 6 0 2 2
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub9.00
Average Interaction Strength6.46
Average Nodes In Shell35.00
Average Hubs In Shell29.00
Average Links In Shell67.00
Average Links Mediated by Hubs In Shell67.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TCR in 9AXF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F38 S:S:W70 2 1 Yes Yes 7 5 2 1
S:S:F38 S:S:Y167 12.38 1 Yes Yes 7 8 2 2
S:S:N64 S:S:P39 3.26 0 Yes Yes 4 6 2 2
S:S:P39 S:S:W70 4.05 1 Yes Yes 6 5 2 1
S:S:P39 S:S:T145 6.99 1 Yes Yes 6 5 2 1
I:I:?6 S:S:P39 9.05 1 Yes Yes 0 6 2 2
S:S:N64 S:S:R66 2.41 0 Yes Yes 4 5 2 1
S:S:G67 S:S:N64 3.39 0 No Yes 4 4 2 2
S:S:R66 S:S:R69 5.33 1 Yes Yes 5 8 1 2
S:S:R66 S:S:W70 10 1 Yes Yes 5 5 1 1
S:S:R66 S:S:S301 2.64 1 Yes No 5 5 1 2
S:S:R66 X:X:?1 4.26 1 Yes Yes 5 0 1 0
S:S:R66 X:X:?2 20.96 1 Yes Yes 5 0 1 2
S:S:G67 S:S:W70 5.63 0 No Yes 4 5 2 1
S:S:R69 S:S:S417 2.64 1 Yes Yes 8 6 2 2
S:S:R69 X:X:?2 9.78 1 Yes Yes 8 0 2 2
S:S:T145 S:S:W70 3.64 1 Yes Yes 5 5 1 1
S:S:W70 S:S:Y167 1.93 1 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 18.79 1 Yes Yes 4 5 1 1
S:S:S417 S:S:W70 3.71 1 Yes Yes 6 5 2 1
S:S:W70 X:X:?1 3.19 1 Yes Yes 5 0 1 0
S:S:W70 X:X:?2 9.17 1 Yes Yes 5 0 1 2
S:S:G146 S:S:T145 1.82 0 No Yes 5 5 2 1
S:S:T145 S:S:Y167 7.49 1 Yes Yes 5 8 1 2
S:S:A168 S:S:T145 3.36 1 Yes Yes 5 5 1 1
S:S:T145 X:X:?1 5.17 1 Yes Yes 5 0 1 0
I:I:?6 S:S:T145 5.41 1 Yes Yes 0 5 2 1
S:S:G146 S:S:S169 1.86 0 No Yes 5 8 2 2
S:S:S147 S:S:S169 1.63 1 Yes Yes 8 8 1 2
S:S:S147 S:S:S171 3.26 1 Yes No 8 7 1 2
S:S:S147 S:S:Y218 2.54 1 Yes Yes 8 7 1 1
S:S:S147 X:X:?1 5.26 1 Yes Yes 8 0 1 0
S:S:A168 S:S:Y167 2.67 1 Yes Yes 5 8 1 2
S:S:I416 S:S:Y167 2.42 1 Yes Yes 4 8 1 2
S:S:A168 S:S:I416 3.25 1 Yes Yes 5 4 1 1
S:S:A168 X:X:?1 2.21 1 Yes Yes 5 0 1 0
S:S:I187 S:S:S170 6.19 1 Yes Yes 6 7 1 1
S:S:D190 S:S:S170 8.83 1 No Yes 8 7 2 1
S:S:S170 S:S:Y218 2.54 1 Yes Yes 7 7 1 1
S:S:S170 X:X:?1 8.42 1 Yes Yes 7 0 1 0
S:S:I187 S:S:R185 3.76 1 Yes Yes 6 9 1 2
S:S:I187 S:S:P188 3.39 1 Yes Yes 6 8 1 2
S:S:I187 S:S:L322 4.28 1 Yes Yes 6 4 1 2
S:S:I187 S:S:N419 4.25 1 Yes No 6 7 1 2
S:S:I187 X:X:?1 2 1 Yes Yes 6 0 1 0
S:S:L322 S:S:P188 3.28 1 Yes Yes 4 8 2 2
S:S:D190 S:S:Q193 6.53 1 No Yes 8 9 2 2
S:S:D190 S:S:Y218 5.75 1 No Yes 8 7 2 1
S:S:Q193 S:S:S296 4.33 1 Yes Yes 9 8 2 2
S:S:E297 S:S:Q193 3.82 0 No Yes 8 9 1 2
S:S:D216 S:S:Y218 5.75 1 No Yes 6 7 2 1
S:S:D216 S:S:G219 1.68 1 No Yes 6 7 2 2
S:S:G219 S:S:Y218 4.35 1 Yes Yes 7 7 2 1
S:S:S296 S:S:Y218 5.09 1 Yes Yes 8 7 2 1
S:S:A298 S:S:Y218 4 1 Yes Yes 6 7 1 1
S:S:Y218 X:X:?1 20.55 1 Yes Yes 7 0 1 0
S:S:A298 S:S:S272 1.71 1 Yes Yes 6 5 1 2
S:S:A298 S:S:S296 1.71 1 Yes Yes 6 8 1 2
S:S:E297 S:S:L322 14.58 0 No Yes 8 4 1 2
S:S:E297 X:X:?1 6.5 0 No Yes 8 0 1 0
S:S:A298 X:X:?1 8.84 1 Yes Yes 6 0 1 0
S:S:I416 X:X:?1 3 1 Yes Yes 4 0 1 0
S:S:I416 X:X:?2 11.49 1 Yes Yes 4 0 1 2
S:S:S417 X:X:?2 8.64 1 Yes Yes 6 0 2 2
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub10.00
Average Interaction Strength6.31
Average Nodes In Shell35.00
Average Hubs In Shell27.00
Average Links In Shell64.00
Average Links Mediated by Hubs In Shell64.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9AYF C Ion Calcium-sensing CaS Homo Sapiens Ca Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 Gi1/Beta1/Gamma2 3.6 2024-04-17 10.1038/s41586-024-07331-1

A 2D representation of the interactions of TCR in 9AYF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F38 S:S:W70 2 1 Yes Yes 7 5 2 1
S:S:F38 S:S:Y167 9.28 1 Yes Yes 7 8 2 2
S:S:G67 S:S:P39 2.03 1 No Yes 4 6 2 2
S:S:P39 S:S:W70 4.05 1 Yes Yes 6 5 2 1
S:S:P39 S:S:T145 5.25 1 Yes Yes 6 5 2 1
I:I:?6 S:S:P39 9.05 1 Yes Yes 0 6 2 2
S:S:N64 S:S:R66 3.62 0 No Yes 4 5 2 1
S:S:G67 S:S:N64 1.7 1 No No 4 4 2 2
S:S:R66 S:S:R69 5.33 1 Yes Yes 5 8 1 2
S:S:R66 S:S:W70 10 1 Yes Yes 5 5 1 1
S:S:R66 X:X:?1 5.11 1 Yes Yes 5 0 1 0
S:S:R66 X:X:?2 22.36 1 Yes Yes 5 0 1 2
M:M:?7 S:S:R66 4.46 0 Yes Yes 0 5 2 1
S:S:G67 S:S:W70 5.63 1 No Yes 4 5 2 1
S:S:R69 S:S:S417 2.64 1 Yes Yes 8 6 2 2
S:S:R69 X:X:?2 13.97 1 Yes Yes 8 0 2 2
S:S:T145 S:S:W70 3.64 1 Yes Yes 5 5 1 1
S:S:W70 S:S:Y167 4.82 1 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 16.44 1 Yes Yes 4 5 1 1
S:S:S417 S:S:W70 4.94 1 Yes Yes 6 5 2 1
S:S:W70 X:X:?1 2.4 1 Yes Yes 5 0 1 0
S:S:W70 X:X:?2 7.86 1 Yes Yes 5 0 1 2
S:S:G146 S:S:T145 1.82 0 No Yes 5 5 2 1
S:S:T145 S:S:Y167 4.99 1 Yes Yes 5 8 1 2
S:S:A168 S:S:T145 3.36 1 No Yes 5 5 2 1
S:S:T145 X:X:?1 3.1 1 Yes Yes 5 0 1 0
I:I:?6 S:S:T145 5.41 1 Yes Yes 0 5 2 1
S:S:G146 S:S:S169 1.86 0 No Yes 5 8 2 2
S:S:S147 S:S:S169 3.26 0 No Yes 8 8 1 2
S:S:S147 S:S:S171 3.26 0 No No 8 7 1 2
S:S:S147 X:X:?1 5.26 0 No Yes 8 0 1 0
S:S:A168 S:S:Y167 2.67 1 No Yes 5 8 2 2
S:S:A168 S:S:I416 1.62 1 No Yes 5 4 2 1
S:S:D190 S:S:S170 8.83 1 Yes No 8 7 2 1
S:S:S170 S:S:Y218 2.54 1 No Yes 7 7 1 1
S:S:S170 X:X:?1 7.37 1 No Yes 7 0 1 0
S:S:D190 S:S:Q193 6.53 1 Yes Yes 8 9 2 2
S:S:D190 S:S:Y218 5.75 1 Yes Yes 8 7 2 1
S:S:D190 S:S:F270 7.17 1 Yes Yes 8 7 2 2
S:S:Q193 S:S:S296 2.89 0 Yes Yes 9 8 2 2
S:S:E297 S:S:Q193 2.55 1 Yes Yes 8 9 1 2
S:S:D216 S:S:Y218 3.45 1 No Yes 6 7 2 1
S:S:D216 S:S:G219 1.68 1 No Yes 6 7 2 2
S:S:G219 S:S:Y218 4.35 1 Yes Yes 7 7 2 1
S:S:F270 S:S:Y218 11.35 1 Yes Yes 7 7 2 1
S:S:S296 S:S:Y218 3.82 1 Yes Yes 8 7 2 1
S:S:A298 S:S:Y218 4 1 No Yes 6 7 1 1
S:S:Y218 X:X:?1 16.44 1 Yes Yes 7 0 1 0
S:S:F270 S:S:G219 3.01 1 Yes Yes 7 7 2 2
S:S:F270 S:S:S296 7.93 1 Yes Yes 7 8 2 2
S:S:A298 S:S:S272 1.71 1 No Yes 6 5 1 2
S:S:E297 S:S:L322 10.6 1 Yes Yes 8 4 1 2
S:S:E297 S:S:I416 4.1 1 Yes Yes 8 4 1 1
S:S:E297 X:X:?1 7.43 1 Yes Yes 8 0 1 0
S:S:A298 X:X:?1 7.73 1 No Yes 6 0 1 0
S:S:I416 S:S:N419 2.83 1 Yes No 4 7 1 2
S:S:I416 X:X:?1 3 1 Yes Yes 4 0 1 0
S:S:I416 X:X:?2 11.49 1 Yes Yes 4 0 1 2
S:S:S417 X:X:?2 6.91 1 Yes Yes 6 0 2 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub6.00
Average Interaction Strength6.43
Average Nodes In Shell33.00
Average Hubs In Shell23.00
Average Links In Shell59.00
Average Links Mediated by Hubs In Shell57.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TCR in 9AYF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F38 R:R:W70 2 1 Yes Yes 7 5 2 1
R:R:F38 R:R:Y167 12.38 1 Yes Yes 7 8 2 2
R:R:N64 R:R:P39 3.26 0 Yes Yes 4 6 2 2
R:R:P39 R:R:W70 4.05 1 Yes Yes 6 5 2 1
R:R:P39 R:R:T145 6.99 1 Yes Yes 6 5 2 1
I:I:?2 R:R:P39 9.05 1 Yes Yes 0 6 2 2
R:R:N64 R:R:R66 3.62 0 Yes Yes 4 5 2 1
R:R:G67 R:R:N64 1.7 0 No Yes 4 4 2 2
R:R:R66 R:R:R69 4.26 1 Yes Yes 5 8 1 2
R:R:R66 R:R:W70 13 1 Yes Yes 5 5 1 1
R:R:R66 W:W:?1 5.11 1 Yes Yes 5 0 1 0
R:R:R66 W:W:?2 20.96 1 Yes Yes 5 0 1 2
L:L:?3 R:R:R66 2.23 1 No Yes 0 5 1 1
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:R69 R:R:S417 3.95 1 Yes Yes 8 6 2 2
R:R:R69 W:W:?2 11.18 1 Yes Yes 8 0 2 2
R:R:T145 R:R:W70 3.64 1 Yes Yes 5 5 1 1
R:R:W70 R:R:Y167 4.82 1 Yes Yes 5 8 1 2
R:R:I416 R:R:W70 14.09 1 Yes Yes 4 5 2 1
R:R:S417 R:R:W70 3.71 1 Yes Yes 6 5 2 1
R:R:W70 W:W:?1 2.4 1 Yes Yes 5 0 1 0
R:R:W70 W:W:?2 7.86 1 Yes Yes 5 0 1 2
R:R:G146 R:R:T145 1.82 0 No Yes 5 5 2 1
R:R:T145 R:R:Y167 4.99 1 Yes Yes 5 8 1 2
R:R:A168 R:R:T145 3.36 1 Yes Yes 5 5 1 1
R:R:T145 W:W:?1 5.17 1 Yes Yes 5 0 1 0
I:I:?2 R:R:T145 5.41 1 Yes Yes 0 5 2 1
R:R:G146 R:R:S169 1.86 0 No Yes 5 8 2 2
R:R:S147 R:R:S169 1.63 0 No Yes 8 8 1 2
R:R:S147 R:R:S171 3.26 0 No No 8 7 1 2
R:R:S147 W:W:?1 5.26 0 No Yes 8 0 1 0
R:R:A168 R:R:Y167 2.67 1 Yes Yes 5 8 1 2
R:R:I416 R:R:Y167 4.84 1 Yes Yes 4 8 2 2
R:R:A168 R:R:I416 1.62 1 Yes Yes 5 4 1 2
R:R:A168 W:W:?1 2.21 1 Yes Yes 5 0 1 0
R:R:I187 R:R:S170 4.64 1 Yes Yes 6 7 2 1
R:R:D190 R:R:S170 8.83 1 No Yes 8 7 2 1
R:R:S170 R:R:Y218 2.54 1 Yes Yes 7 7 1 1
R:R:S170 W:W:?1 7.37 1 Yes Yes 7 0 1 0
R:R:I187 R:R:L322 2.85 1 Yes Yes 6 4 2 2
R:R:D190 R:R:Q193 5.22 1 No Yes 8 9 2 2
R:R:D190 R:R:Y218 5.75 1 No Yes 8 7 2 1
R:R:Q193 R:R:S296 2.89 1 Yes Yes 9 8 2 2
R:R:E297 R:R:Q193 3.82 0 No Yes 8 9 1 2
R:R:D216 R:R:Y218 3.45 1 Yes Yes 6 7 2 1
R:R:S296 R:R:Y218 5.09 1 Yes Yes 8 7 2 1
R:R:A298 R:R:Y218 4 1 Yes Yes 6 7 1 1
R:R:Y218 W:W:?1 18.08 1 Yes Yes 7 0 1 0
R:R:A298 R:R:S272 1.71 1 Yes Yes 6 5 1 2
R:R:A298 R:R:S296 1.71 1 Yes Yes 6 8 1 2
R:R:E297 R:R:L322 10.6 0 No Yes 8 4 1 2
R:R:E297 W:W:?1 5.57 0 No Yes 8 0 1 0
R:R:A298 W:W:?1 7.73 1 Yes Yes 6 0 1 0
L:L:?3 R:R:S302 5.51 1 No Yes 0 5 1 2
R:R:I416 W:W:?2 11.49 1 Yes Yes 4 0 2 2
R:R:S417 W:W:?2 6.91 1 Yes Yes 6 0 2 2
L:L:?3 W:W:?1 1.78 1 No Yes 0 0 1 0
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub7.00
Average Interaction Strength6.07
Average Nodes In Shell32.00
Average Hubs In Shell25.00
Average Links In Shell57.00
Average Links Mediated by Hubs In Shell56.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links9.70
Average Number Of Links With An Hub6.70
Average Interaction Strength7.03
Average Nodes In Shell29.00
Average Hubs In Shell19.10
Average Links In Shell50.40
Average Links Mediated by Hubs In Shell49.60

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)