Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1K:K:?1 3.8851240
2K:K:W4 4.70333610
3K:K:?5 8.93610
4R:R:F38 4.56627
5R:R:H41 7.148527
6R:R:F42 8.385473
7R:R:V44 3.2475422
8R:R:L51 4.2325406
9R:R:R62 5.175474
10R:R:Y63 7.09167625
11R:R:F65 5.035622
12R:R:R66 7.8275425
13R:R:F68 6.05833627
14R:R:R69 5.87628
15R:R:W70 7.21143725
16R:R:L71 3.356524
17R:R:Q72 5.304527
18R:R:M74 3.08628
19R:R:I75 4.2424
20R:R:F76 5.354527
21R:R:Y95 6.838528
22R:R:R96 5.42754284
23R:R:I97 3.85833628
24R:R:F98 8.468504
25R:R:D99 6.14429
26R:R:C101 4.89428
27R:R:F114 4.33455
28R:R:T145 4.06833625
29R:R:S147 3.6975428
30R:R:V153 4.51456
31R:R:L157 4.266557
32R:R:I162 3.96406
33R:R:P163 3.396508
34R:R:Q164 5.04333658
35R:R:Y167 4.23143728
36R:R:R172 4.8975404
37R:R:L173 5.1775405
38R:R:L174 8.105457
39R:R:F180 6.745455
40R:R:F183 7.108558
41R:R:R185 5.52659
42R:R:I187 3.3175406
43R:R:M197 4.1275407
44R:R:I201 3.62406
45R:R:Y203 5.475495
46R:R:F204 8.634597
47R:R:W206 6.48333699
48R:R:W208 6.503336119
49R:R:T211 4.1275405
50R:R:I212 3.3425406
51R:R:Y218 3.68125827
52R:R:I223 4.0475405
53R:R:K225 6.544383
54R:R:F226 3.2075406
55R:R:E229 4.8345385
56R:R:R233 7.24404
57R:R:C236 3.3654119
58R:R:F239 5.1285116
59R:R:Q260 2.55254175
60R:R:V266 5.348597
61R:R:F270 4.235407
62R:R:G273 2.8275474
63R:R:P274 3.706573
64R:R:L276 5.955475
65R:R:E277 5.785472
66R:R:L279 4.3275405
67R:R:E282 6.4325176
68R:R:R286 4.9756174
69R:R:L294 3.2825407
70R:R:W299 5.3777
71R:R:L304 4.486572
72R:R:I305 4.164574
73R:R:Y310 4.345193
74R:R:F320 4.17406
75R:R:G325 3.9425424
76R:R:I327 4.018526
77R:R:F330 4.69143728
78R:R:F333 5.94427
79R:R:L334 5.93333626
80R:R:V337 2.115425
81R:R:N345 3.1875428
82R:R:F347 3.545625
83R:R:F351 7.68626
84R:R:W352 10.188528
85R:R:T355 6.3775424
86R:R:F356 10.582528
87R:R:H359 1.4775404
88R:R:L360 6.18254394
89R:R:I401 2.348527
90R:R:Y408 6.45723
91R:R:Y411 7.4525425
92R:R:L414 4.1975426
93R:R:R415 5.51405
94R:R:S417 3.434526
95R:R:Y418 6.09167627
96R:R:Y421 5.89857728
97R:R:Y425 8.8675428
98R:R:F444 2.92754183
99R:R:W458 7.6285184
100R:R:Q459 5.3745187
101R:R:L461 3.9954377
102R:R:L467 3.525427
103R:R:F469 8.556528
104R:R:N471 3.536526
105R:R:M473 4.0675424
106R:R:D484 5.582558
107R:R:Y489 5.225408
108R:R:W494 5.84286777
109R:R:S497 2.8975403
110R:R:I503 4.255474
111R:R:F505 4.542574
112R:R:Y511 4.73714705
113R:R:N512 3.654414
114R:R:Y514 3.4745414
115R:R:L521 3.31495
116R:R:W530 8.17167698
117R:R:T550 2.83254426
118R:R:K552 7.96408
119R:R:P559 2.44116
120R:R:C568 3.88754299
121R:R:C582 5.2954299
122R:R:W590 7.135406
123R:R:C598 4.354319
124R:R:W608 6.0675405
125R:R:L616 5.5625408
126R:R:V630 5.06487
127R:R:V633 4.6525485
128R:R:F634 3.716589
129R:R:F637 4.558584
130R:R:N647 6.3254159
131R:R:R648 4.9075408
132R:R:F662 5.2856208
133R:R:F668 6.25409
134R:R:P672 3.8425469
135R:R:C677 2.89569
136R:R:Q681 7.4475469
137R:R:F684 6.49667668
138R:R:R701 6.7154158
139R:R:F706 5.685219
140R:R:H715 6.015155
141R:R:W719 4.9254156
142R:R:Q724 7.80254158
143R:R:Q735 7.54409
144R:R:W742 4.97167669
145R:R:P748 3.04167669
146R:R:Y751 8.7654123
147R:R:I761 3.48407
148R:R:F762 8.37754127
149R:R:I763 4.7875467
150R:R:F788 5.985138
151R:R:L797 3.665218
152R:R:N800 3.5165437
153R:R:F801 5.40754219
154R:R:F806 6.1175405
155R:R:F814 7.12409
156R:R:F815 4.3375407
157R:R:I816 3.955408
158R:R:W818 7.066569
159R:R:F821 4.24833609
160R:R:Y829 5.24126
161R:R:I841 6.3125469
162R:R:I852 4.955409
163R:R:F853 6.095689
164R:R:I857 5.1125488
165R:R:I860 3.78489
166R:R:L861 3.795485
167R:R:N867 9.8875489
168S:S:G30 1.85754449
169S:S:G35 3.115438
170S:S:F38 4.74833617
171S:S:H41 6.924517
172S:S:F42 8.3475413
173S:S:P55 5.9254186
174S:S:Y63 5.93429715
175S:S:F65 5.41612
176S:S:R66 8.9275415
177S:S:F68 4.69143717
178S:S:R69 5.53618
179S:S:W70 5.37444915
180S:S:L71 4.34143714
181S:S:Q72 4.37571717
182S:S:M74 3.416518
183S:S:I75 4.2325414
184S:S:F76 5.53517
185S:S:L87 4.9625416
186S:S:Y95 5.964518
187S:S:R96 3.63504
188S:S:I97 4.805418
189S:S:F98 7.02534
190S:S:D99 6.2125419
191S:S:C101 6.0625418
192S:S:L112 1.38455
193S:S:F114 3.69635
194S:S:I135 4.895404
195S:S:T145 3.98615
196S:S:T151 3.2125435
197S:S:V153 4.51436
198S:S:L157 3.702537
199S:S:F160 5.768537
200S:S:I162 3.252536
201S:S:P163 2.41538
202S:S:Q164 6.045438
203S:S:Y167 4.96286718
204S:S:R172 5.755434
205S:S:L173 4.528535
206S:S:L174 7.1275437
207S:S:F180 5.886535
208S:S:F183 5.99167638
209S:S:L184 3.54406
210S:S:R185 6.156539
211S:S:Q193 5.184519
212S:S:I200 3.06418
213S:S:I201 3.334506
214S:S:F204 6.514517
215S:S:W206 6.128519
216S:S:W208 7.252867169
217S:S:T211 3.634505
218S:S:Y218 3.79817
219S:S:K225 6.2025403
220S:S:F226 2.6225406
221S:S:E229 5.84754465
222S:S:R233 6.4865464
223S:S:F239 4.8325166
224S:S:V269 4.062515
225S:S:F270 4.7325417
226S:S:S271 3.7025414
227S:S:G273 2.8275414
228S:S:P274 3.39513
229S:S:D275 3.9075415
230S:S:L276 5.046515
231S:S:I280 3.1225415
232S:S:E282 5.6925246
233S:S:R286 4.5856244
234S:S:W293 5.64418
235S:S:S296 4.625418
236S:S:W299 6.06833617
237S:S:L304 3.7725412
238S:S:I305 3.56514
239S:S:Y310 4.324513
240S:S:F311 6.8625403
241S:S:V313 3.8275403
242S:S:F320 4.83516
243S:S:I327 4.21333616
244S:S:F330 4.62618
245S:S:R331 8.29414
246S:S:F333 5.626517
247S:S:L334 5.33833616
248S:S:V337 2.782515
249S:S:N345 3.186518
250S:S:F347 4.09833615
251S:S:F351 7.18333616
252S:S:W352 10.85418
253S:S:T355 6.3775414
254S:S:F356 10.4675418
255S:S:L360 4.525404
256S:S:E399 8.1075418
257S:S:Y408 6.56571713
258S:S:I409 3.9625415
259S:S:Y411 7.23415
260S:S:L414 4.9575416
261S:S:R415 6.2875415
262S:S:Y418 5.05517
263S:S:Y421 9.132518
264S:S:Y425 8.3725418
265S:S:Y435 3.39254453
266S:S:F444 3.2354233
267S:S:W458 8.6965234
268S:S:Q459 6.985237
269S:S:K462 4.092504
270S:S:L464 3.7375407
271S:S:F469 8.82518
272S:S:N471 4.9516
273S:S:M473 3.91333614
274S:S:D484 7.0175438
275S:S:Y489 2.9825418
276S:S:W494 6.52617
277S:S:S497 2.8585323
278S:S:D500 3.894324
279S:S:Y511 4.02714705
280S:S:Y514 5.824484
281S:S:L521 4.675415
282S:S:W530 5.14375818
283S:S:C546 4.56254309
284S:S:K552 8.234308
285S:S:P559 3.18754166
286S:S:C562 4.054169
287S:S:F563 6.6154307
288S:S:C568 3.08754339
289S:S:Y573 4.99754256
290S:S:D578 7.40754307
291S:S:C582 4.50754339
292S:S:C585 3.39254259
293S:S:T596 2.3175405
294S:S:C598 5.8254259
295S:S:W608 4.0425405
296S:S:G623 3.8654146
297S:S:T627 4.0225147
298S:S:F634 4.0025409
299S:S:I635 3.0825404
300S:S:I642 4.854547
301S:S:L650 5.73254348
302S:S:L654 3.455408
303S:S:L655 5.16254149
304S:S:L658 3.65754148
305S:S:F662 6.788336148
306S:S:F668 7.8525109
307S:S:P672 3.8085109
308S:S:W675 5.13754493
309S:S:R680 7.0825108
310S:S:Q681 6.0145109
311S:S:F684 5.15167648
312S:S:F688 4.31333648
313S:S:V689 3.6054277
314S:S:I695 3.492547
315S:S:Q724 5.414348
316S:S:Q735 5.218336279
317S:S:P747 2.135408
318S:S:Q754 4.354264
319S:S:F762 4.56254227
320S:S:I763 5.134107
321S:S:C765 5.964109
322S:S:Y779 5.0154279
323S:S:F790 5.01407
324S:S:N800 4.0675447
325S:S:F801 6.7325449
326S:S:E803 4.304549
327S:S:K805 7.1454139
328S:S:I807 3.33449
329S:S:M811 4.13667649
330S:S:F814 5.264509
331S:S:W818 5.74667649
332S:S:Y825 6.2775449
333S:S:S827 3.5225408
334S:S:V838 4.3975407
335S:S:L848 3.16447
336S:S:F853 4.256149
337S:S:I859 6.9425449
338S:S:K863 15.255447
339W:W:?1 4.7755618130
340W:W:W4 4.35286720
341W:W:?5 8.63833620
342W:W:W6 7.442560
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1K:K:?1 S:S:P823 34.97084.36YesNo409
2R:R:F821 S:S:P823 35.14324.33YesNo099
3R:R:A840 R:R:F821 35.93392.77NoYes099
4R:R:A840 R:R:W818 36.02057.78NoYes099
5R:R:W818 W:W:W6 84.710312.18YesYes690
6R:R:Q681 W:W:W6 97.10643.29YesYes690
7R:R:Q681 R:R:W742 48.69574.38YesYes699
8R:R:P748 R:R:W742 51.02876.76YesYes699
9R:R:C677 R:R:P748 99.84291.88YesYes699
10R:R:C677 R:R:P672 99.781.88YesYes699
11R:R:I763 R:R:P672 99.82868.47YesYes679
12R:R:I603 R:R:I763 50.01712.94NoYes047
13R:R:I603 R:R:I761 49.94792.94NoYes047
14R:R:I761 R:R:K601 99.77795.82YesNo078
15R:R:K601 R:R:W590 99.76053.48NoYes086
16R:R:G571 R:R:W590 1008.44NoYes076
17R:R:G571 R:R:S591 99.98243.71NoNo078
18R:R:H595 R:R:S591 99.96475.58NoNo058
19R:R:C568 R:R:H595 99.92942.95YesNo095
20R:R:C568 R:R:C582 99.75777.28YesYes2999
21R:R:C582 R:R:R551 99.7265.57YesNo097
22R:R:R551 R:R:V566 99.164810.46NoNo074
23R:R:G553 R:R:V566 99.14641.84NoNo064
24R:R:G553 R:R:K552 99.12811.74NoYes068
25R:R:K552 S:S:I554 98.92462.91YesNo083
26R:R:I554 S:S:I554 98.86874.42NoNo033
27R:R:I554 S:S:G553 98.85011.76NoNo036
28S:S:G553 S:S:K552 98.83141.74NoYes068
29S:S:F563 S:S:K552 98.554116.13YesYes3078
30S:S:F563 S:S:S543 98.50243.96YesNo078
31S:S:C542 S:S:S543 98.48363.44NoNo098
32S:S:C542 S:S:W208 98.064116.98NoYes1699
33S:S:D238 S:S:W208 98.142614.52NoYes1689
34S:S:D238 S:S:F239 98.08323.58NoYes1686
35S:S:F239 S:S:G210 75.57637.53YesNo068
36S:S:G210 S:S:T211 65.57551.82NoYes085
37S:S:F226 S:S:T211 22.39092.59YesYes065
38S:S:F226 S:S:V268 21.61272.62YesNo066
39S:S:M197 S:S:V268 21.61033.04NoNo076
40S:S:F270 S:S:M197 21.56876.22YesNo077
41S:S:F270 S:S:Y218 16.46133.09YesYes177
42K:K:W4 S:S:Y218 32.60763.86YesYes107
43K:K:W4 S:S:W70 24.93751.87YesYes105
44S:S:F38 S:S:W70 13.80452YesYes175
45S:S:F38 S:S:I97 10.71692.51YesYes178
46S:S:G36 S:S:I97 11.06053.53NoYes078
47S:S:G35 S:S:G36 10.98742.11YesNo087
48S:S:I162 S:S:L157 10.86454.28YesYes367
49R:R:E767 R:R:Q681 48.656611.47NoYes679
50R:R:E767 R:R:P748 48.69123.14NoYes679
51R:R:I763 R:R:R752 49.87985.01YesNo073
52R:R:I761 R:R:R752 49.88213.76YesNo073
53S:S:F239 S:S:I259 22.59642.51YesNo066
54S:S:I259 S:S:K291 22.55342.91NoNo066
55S:S:K291 S:S:W293 22.37473.48NoYes168
56S:S:V269 S:S:W293 19.70482.45YesYes158
57S:S:V269 S:S:W299 17.88948.58YesYes157
58S:S:S296 S:S:W299 17.08382.47YesYes187
59S:S:S296 S:S:Y218 16.47455.09YesYes187
60S:S:I237 S:S:T211 45.65123.04NoYes065
61S:S:I237 S:S:R227 45.61372.51NoNo064
62S:S:E224 S:S:R227 45.53918.14NoNo064
63R:R:E224 S:S:E224 45.503310.15NoNo066
64R:R:E224 R:R:I223 45.46952.73NoYes065
65R:R:F270 R:R:I223 43.02532.51YesYes075
66R:R:F270 R:R:S296 38.70583.96YesNo078
67R:R:S296 R:R:Y218 34.93955.09NoYes087
68R:R:Y218 W:W:W4 29.80183.86YesYes270
69R:R:R66 W:W:W4 13.33463YesYes250
70R:R:T145 W:W:W4 10.60116.06YesYes250
71R:R:F38 R:R:M74 10.38753.73YesYes278
72R:R:L34 R:R:M74 14.7282.83NoYes078
73R:R:L34 R:R:L93 13.17524.15NoNo079
74R:R:I32 R:R:L93 12.11964.28NoNo069
75K:K:?1 S:S:C781 23.07273.16YesNo007
76S:S:C781 S:S:F814 22.98964.19NoYes079
77S:S:F814 S:S:W818 10.619710.02YesYes099
78S:S:V817 S:S:W818 21.6273.68NoYes099
79R:R:I816 S:S:V817 10.90794.61YesNo089
80R:R:I816 W:W:?1 11.44486.64YesYes080
81K:K:?1 S:S:Y825 10.86517.79YesYes409
82S:S:F821 S:S:Y825 10.70637.22NoYes499
83S:S:F821 S:S:W818 10.63016.01NoYes499
84S:S:A843 S:S:V817 10.89743.39NoNo079
85S:S:A843 W:W:?1 10.98765.23NoYes070
86R:R:F788 W:W:?1 45.77278.09YesYes1380
87R:R:F814 R:R:W818 47.155211.02YesYes099
88R:R:F814 R:R:F815 47.22017.5YesYes097
89R:R:F788 R:R:F815 46.96784.29YesYes087
90S:S:F688 S:S:F814 12.13895.36YesYes089
91S:S:F684 S:S:F688 10.42087.5YesYes488
92S:S:F684 S:S:I841 40.803910.05YesNo089
93S:S:F668 S:S:I841 40.35582.51YesNo099
94S:S:F668 S:S:V838 13.4873.93YesYes097
95S:S:L616 S:S:V838 12.58537.45NoYes087
96S:S:F612 S:S:L616 12.13623.65NoNo088
97S:S:F612 S:S:F832 11.23787.5NoNo085
98S:S:F684 S:S:W818 41.61135.01YesYes489
99S:S:G210 S:S:V209 10.01353.68NoNo088
100S:S:F832 S:S:K831 10.33978.69NoNo059
101S:S:F668 S:S:R680 18.423416.03YesYes1098
102S:S:C765 S:S:R680 10.33619.75YesYes1098
103S:S:Q681 S:S:W742 11.69352.19YesNo099
104S:S:F684 S:S:G685 10.35054.52YesNo088
105S:S:C851 S:S:S810 14.22483.44NoNo089
106S:S:C851 W:W:?1 14.31292.11NoYes080
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
K:K:?1 R:R:F832 4.86 4 Yes No 0 5 0 1
K:K:?1 R:R:A843 2.09 4 Yes No 0 7 0 1
K:K:?1 S:S:L770 2.76 4 Yes No 0 3 0 1
K:K:?1 S:S:C781 3.16 4 Yes No 0 7 0 1
K:K:?1 S:S:I819 3.79 4 Yes No 0 6 0 1
K:K:?1 S:S:I822 3.79 4 Yes No 0 7 0 1
K:K:?1 S:S:P823 4.36 4 Yes No 0 9 0 1
K:K:?1 S:S:Y825 7.79 4 Yes Yes 0 9 0 1
K:K:?1 S:S:A826 4.19 4 Yes No 0 5 0 1
K:K:?1 S:S:Y829 6.23 4 Yes No 0 6 0 1
K:K:?1 S:S:V833 1.98 4 Yes No 0 6 0 1
R:R:F821 S:S:P823 4.33 0 Yes No 9 9 2 1
R:R:T828 S:S:S827 4.8 0 No Yes 8 8 2 2
R:R:T828 S:S:Y829 8.74 0 No No 8 6 2 1
R:R:F832 S:S:S827 2.64 0 No Yes 5 8 1 2
S:S:C781 S:S:F814 4.19 0 No Yes 7 9 1 2
S:S:A785 S:S:F815 2.77 0 No No 2 7 2 1
S:S:F821 S:S:Y825 7.22 4 No Yes 9 9 2 1
S:S:F821 S:S:V836 6.55 4 No No 9 8 2 2
S:S:I822 S:S:P823 5.08 4 No No 7 9 1 1
S:S:V833 S:S:Y825 5.05 4 No Yes 6 9 1 1
S:S:V836 S:S:Y825 5.05 4 No Yes 8 9 2 1
S:S:T828 S:S:V833 3.17 0 No No 8 6 2 1
K:K:?1 S:S:F815 1.62 4 Yes No 0 7 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
K:K:W4 S:S:R66 6 1 Yes Yes 0 5 0 1
K:K:W4 S:S:W70 1.87 1 Yes Yes 0 5 0 1
K:K:W4 S:S:T145 6.06 1 Yes Yes 0 5 0 1
K:K:W4 S:S:A168 3.89 1 Yes No 0 5 0 1
K:K:W4 S:S:Y218 3.86 1 Yes Yes 0 7 0 1
K:K:W4 S:S:E297 6.54 1 Yes No 0 8 0 1
K:K:?5 S:S:R66 15.38 1 Yes Yes 0 5 2 1
K:K:?5 S:S:R69 13.98 1 Yes Yes 0 8 2 2
K:K:?5 S:S:W70 6.55 1 Yes Yes 0 5 2 1
K:K:?5 S:S:I416 6.57 1 Yes No 0 4 2 2
K:K:?5 S:S:S417 6.91 1 Yes No 0 6 2 2
S:S:F38 S:S:W70 2 1 Yes Yes 7 5 2 1
S:S:F38 S:S:Y167 10.32 1 Yes Yes 7 8 2 2
S:S:P39 S:S:T145 5.25 0 No Yes 6 5 2 1
S:S:R66 S:S:R69 5.33 1 Yes Yes 5 8 1 2
S:S:R66 S:S:W70 9 1 Yes Yes 5 5 1 1
S:S:R69 S:S:W70 2 1 Yes Yes 8 5 2 1
S:S:T145 S:S:W70 3.64 1 Yes Yes 5 5 1 1
S:S:W70 S:S:Y167 6.75 1 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 14.09 1 No Yes 4 5 2 1
S:S:S417 S:S:W70 2.47 1 No Yes 6 5 2 1
S:S:G146 S:S:T145 1.82 0 No Yes 5 5 2 1
S:S:T145 S:S:Y167 3.75 1 Yes Yes 5 8 1 2
S:S:A168 S:S:T145 3.36 1 No Yes 5 5 1 1
S:S:S147 S:S:Y218 2.54 0 No Yes 8 7 2 1
S:S:A168 S:S:Y167 2.67 1 No Yes 5 8 1 2
S:S:I416 S:S:Y167 2.42 1 No Yes 4 8 2 2
S:S:D190 S:S:S170 8.83 1 No No 8 7 2 2
S:S:S170 S:S:Y218 2.54 1 No Yes 7 7 2 1
S:S:D190 S:S:Q193 2.61 1 No Yes 8 9 2 2
S:S:D190 S:S:Y218 6.9 1 No Yes 8 7 2 1
S:S:Q193 S:S:S296 4.33 1 Yes Yes 9 8 2 2
S:S:E297 S:S:Q193 5.1 0 No Yes 8 9 1 2
S:S:D216 S:S:Y218 2.3 1 No Yes 6 7 2 1
S:S:F270 S:S:Y218 3.09 1 Yes Yes 7 7 2 1
S:S:S296 S:S:Y218 5.09 1 Yes Yes 8 7 2 1
S:S:A298 S:S:Y218 4 0 No Yes 6 7 2 1
S:S:F270 S:S:S296 6.61 1 Yes Yes 7 8 2 2
S:S:E297 S:S:L322 2.65 0 No No 8 4 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F788 R:R:T808 5.19 13 Yes No 8 9 1 1
R:R:F788 R:R:M811 7.46 13 Yes No 8 9 1 2
R:R:F788 R:R:L812 4.87 13 Yes No 8 9 1 1
R:R:F788 R:R:F815 4.29 13 Yes Yes 8 7 1 2
R:R:F788 W:W:?1 8.09 13 Yes Yes 8 0 1 0
R:R:F792 R:R:R795 14.97 13 No No 8 9 1 1
R:R:F792 W:W:?1 4.05 13 No Yes 8 0 1 0
R:R:K796 R:R:R795 9.9 13 No No 7 9 1 1
R:R:R795 W:W:?1 7.26 13 No Yes 9 0 1 0
R:R:K796 W:W:?1 1.87 13 No Yes 7 0 1 0
R:R:F806 R:R:K805 9.93 0 Yes No 5 9 2 1
R:R:K805 W:W:?1 6.56 0 No Yes 9 0 1 0
R:R:T808 W:W:?1 5.88 13 No Yes 9 0 1 0
R:R:F809 S:S:F809 3.22 0 No No 9 9 2 1
R:R:L812 W:W:?1 4.6 13 No Yes 9 0 1 0
R:R:I816 S:S:V817 4.61 0 Yes No 8 9 1 2
R:R:I816 S:S:S820 3.1 0 Yes No 8 7 1 2
R:R:I816 W:W:?1 6.64 0 Yes Yes 8 0 1 0
R:R:I819 W:W:?1 10.43 0 No Yes 6 0 1 0
S:S:K805 S:S:N802 11.19 13 Yes No 9 9 1 2
S:S:F806 S:S:K805 6.2 0 No Yes 5 9 2 1
S:S:F809 S:S:K805 7.44 13 No Yes 9 9 1 1
S:S:K805 W:W:?1 3.75 13 Yes Yes 9 0 1 0
S:S:F809 W:W:?1 9.71 13 No Yes 9 0 1 0
S:S:C851 S:S:S810 3.44 0 No No 8 9 1 2
S:S:I813 W:W:?1 1.9 0 No Yes 8 0 1 0
S:S:A843 S:S:V817 3.39 0 No No 7 9 1 2
S:S:I839 W:W:?1 1.9 0 No Yes 7 0 1 0
S:S:A843 W:W:?1 5.23 0 No Yes 7 0 1 0
S:S:G847 W:W:?1 2.27 0 No Yes 8 0 1 0
S:S:A850 W:W:?1 2.09 0 No Yes 1 0 1 0
S:S:C851 W:W:?1 2.11 0 No Yes 8 0 1 0
S:S:F619 W:W:?1 1.62 0 No Yes 3 0 1 0
R:R:I816 S:S:I816 1.47 0 Yes No 8 8 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C661 R:R:F684 2.79 0 No Yes 7 8 2 1
R:R:Q681 R:R:W742 4.38 6 Yes Yes 9 9 1 2
R:R:E767 R:R:Q681 11.47 6 No Yes 7 9 2 1
R:R:L773 R:R:Q681 10.65 0 No Yes 8 9 2 1
R:R:Q681 W:W:W6 3.29 6 Yes Yes 9 0 1 0
R:R:F684 R:R:G685 3.01 6 Yes No 8 8 1 2
R:R:F684 R:R:W818 2 6 Yes Yes 8 9 1 1
R:R:F684 R:R:I841 18.84 6 Yes Yes 8 9 1 2
R:R:F684 W:W:W6 11.02 6 Yes Yes 8 0 1 0
R:R:F688 R:R:T780 2.59 0 No No 8 7 2 1
R:R:F688 R:R:F814 8.57 0 No Yes 8 9 2 2
R:R:Q735 R:R:T780 4.25 0 Yes No 9 7 2 1
R:R:E767 R:R:W742 3.27 6 No Yes 7 9 2 2
R:R:I777 R:R:L773 4.28 0 No No 8 8 1 2
R:R:I777 W:W:W6 5.87 0 No Yes 8 0 1 0
R:R:T780 W:W:W6 4.85 0 No Yes 7 0 1 0
R:R:F814 R:R:W818 11.02 0 Yes Yes 9 9 2 1
R:R:A840 R:R:W818 7.78 0 No Yes 9 9 2 1
R:R:I841 R:R:W818 2.35 6 Yes Yes 9 9 2 1
R:R:W818 W:W:W6 12.18 6 Yes Yes 9 0 1 0
R:R:F684 R:R:S664 1.32 6 Yes No 8 6 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P39 R:R:T145 6.99 0 No Yes 6 5 2 1
R:R:R66 R:R:R69 5.33 2 Yes Yes 5 8 1 2
R:R:R66 R:R:W70 9 2 Yes Yes 5 5 1 2
R:R:R66 W:W:W4 3 2 Yes Yes 5 0 1 0
R:R:R66 W:W:?5 13.98 2 Yes Yes 5 0 1 2
R:R:R69 W:W:?5 11.18 2 Yes Yes 8 0 2 2
R:R:T145 R:R:W70 2.43 2 Yes Yes 5 5 1 2
R:R:W70 R:R:Y167 2.89 2 Yes Yes 5 8 2 2
R:R:W70 W:W:?5 10.48 2 Yes Yes 5 0 2 2
R:R:G146 R:R:T145 1.82 0 No Yes 5 5 2 1
R:R:T145 R:R:Y167 3.75 2 Yes Yes 5 8 1 2
R:R:A168 R:R:T145 3.36 2 No Yes 5 5 1 1
R:R:T145 W:W:W4 6.06 2 Yes Yes 5 0 1 0
R:R:S147 R:R:S169 3.26 2 Yes No 8 8 1 2
R:R:S147 R:R:S171 6.52 2 Yes No 8 7 1 2
R:R:S147 R:R:Y218 2.54 2 Yes Yes 8 7 1 1
R:R:S147 W:W:W4 2.47 2 Yes Yes 8 0 1 0
R:R:A168 R:R:Y167 2.67 2 No Yes 5 8 1 2
R:R:A168 W:W:W4 3.89 2 No Yes 5 0 1 0
R:R:D190 R:R:S170 8.83 2 No No 8 7 2 1
R:R:S170 R:R:Y218 2.54 2 No Yes 7 7 1 1
R:R:S170 W:W:W4 2.47 2 No Yes 7 0 1 0
R:R:D190 R:R:Q193 6.53 2 No No 8 9 2 2
R:R:D190 R:R:Y218 5.75 2 No Yes 8 7 2 1
R:R:E297 R:R:Q193 5.1 2 No No 8 9 1 2
R:R:D216 R:R:Y218 2.3 0 No Yes 6 7 2 1
R:R:S296 R:R:Y218 5.09 0 No Yes 8 7 2 1
R:R:E297 R:R:Y218 3.37 2 No Yes 8 7 1 1
R:R:A298 R:R:Y218 4 0 No Yes 6 7 2 1
R:R:Y218 W:W:W4 3.86 2 Yes Yes 7 0 1 0
R:R:E297 W:W:W4 8.72 2 No Yes 8 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8SZI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 1.82
Number of Linked Nodes 1547
Number of Links 1991
Number of Hubs 342
Number of Links mediated by Hubs 1255
Number of Communities 50
Number of Nodes involved in Communities 528
Number of Links involved in Communities 795
Path Summary
Number Of Nodes in MetaPath 107
Number Of Links MetaPath 106
Number of Shortest Paths 13526984
Length Of Smallest Path 3
Average Path Length 54.7983
Length of Longest Path 84
Minimum Path Strength 1.18
Average Path Strength 4.79534
Maximum Path Strength 20.745
Minimum Path Correlation 0.7
Average Path Correlation 0.999123
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.92308
Average % Of Corr. Nodes 54.9946
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 57.3773
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • GDP binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • cation binding   • metal ion binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular process   • cell division   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • regulation of molecular function   • negative regulation of lyase activity
Gene OntologyBiological Process• cellular process   • cell division   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • regulation of molecular function   • negative regulation of lyase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • positive regulation of autophagy   • catabolic process   • macroautophagy   • autophagy   • positive regulation of biological process   • regulation of catabolic process   • regulation of autophagy   • positive regulation of catabolic process   • positive regulation of metabolic process   • regulation of macroautophagy   • metabolic process   • positive regulation of macroautophagy   • process utilizing autophagic mechanism   • regulation of metabolic process   • positive regulation of cellular process   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • nucleoside phosphate metabolic process   • ribose phosphate metabolic process   • purine nucleoside triphosphate metabolic process   • GTP metabolic process   • carbohydrate derivative metabolic process   • primary metabolic process   • nucleotide metabolic process   • purine-containing compound metabolic process   • nucleobase-containing compound metabolic process   • purine nucleotide metabolic process   • ribonucleotide metabolic process   • organophosphate metabolic process   • nucleobase-containing small molecule metabolic process   • purine ribonucleoside triphosphate metabolic process   • phosphate-containing compound metabolic process   • small molecule metabolic process   • nucleoside triphosphate metabolic process   • purine ribonucleotide metabolic process   • phosphorus metabolic process   • ribonucleoside triphosphate metabolic process   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytoplasm   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • amino acid binding   • identical protein binding   • cation binding   • ion binding   • calcium ion binding   • metal ion binding   • small molecule binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • phosphoric ester hydrolase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • phospholipase C activity   • phosphatidylinositol-4,5-bisphosphate phospholipase C activity   • phospholipase activity   • lipase activity   • transmembrane transporter binding   • cell adhesion molecule binding   • integrin binding   • signaling receptor binding   • protein homodimerization activity   • protein dimerization activity   • kinase binding   • protein kinase binding   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • epithelium development   • tube development   • branching morphogenesis of an epithelial tube   • morphogenesis of an epithelium   • tissue development   • tissue morphogenesis   • anatomical structure morphogenesis   • tube morphogenesis   • morphogenesis of a branching structure   • epithelial tube morphogenesis   • morphogenesis of a branching epithelium   • regulation of tube diameter   • regulation of tube size   • regulation of system process   • positive regulation of biological process   • positive regulation of vasoconstriction   • circulatory system process   • regulation of blood circulation   • vascular process in circulatory system   • regulation of vasoconstriction   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • blood vessel diameter maintenance   • vasoconstriction   • blood circulation   • regulation of anatomical structure size   • monoatomic ion transmembrane transport   • inorganic ion transmembrane transport   • inorganic anion transmembrane transport   • chloride transport   • transmembrane transport   • chloride transmembrane transport   • monoatomic anion transport   • monoatomic anion transmembrane transport   • inorganic anion transport   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • response to stress   • response to ischemia   • response to decreased oxygen levels   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to stress   • response to hypoxia   • response to oxygen levels   • response to abiotic stimulus   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • organic acid transport   • bile acid secretion   • organic anion transport   • monocarboxylic acid transport   • carboxylic acid transport   • secretion   • acid secretion   • response to peptide   • cellular response to peptide   • behavior   • chemosensory behavior   • JNK cascade   • MAPK cascade   • cellular response to low-density lipoprotein particle stimulus   • response to lipoprotein particle   • cellular response to lipoprotein particle stimulus   • regulation of calcium ion import   • positive regulation of calcium ion transport   • positive regulation of calcium ion import   • positive regulation of transport   • positive regulation of monoatomic ion transport   • calcium ion import   • ossification   • connective tissue development   • adipose tissue development   • fat pad development   • response to fibroblast growth factor   • response to growth factor   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • cellular response to glucose stimulus   • intracellular glucose homeostasis   • response to hexose   • cellular response to carbohydrate stimulus   • response to monosaccharide   • response to carbohydrate   • response to glucose   • glucose homeostasis   • carbohydrate homeostasis   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • response to nutrient levels   • response to nutrient   • response to vitamin   • cellular response to vitamin D   • cellular response to nutrient levels   • response to vitamin D   • cellular response to vitamin   • cellular response to nutrient   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • vasodilation   • positive chemotaxis   • chemotaxis   • positive regulation of locomotion   • regulation of response to external stimulus   • positive regulation of positive chemotaxis   • response to external stimulus   • regulation of chemotaxis   • positive regulation of chemotaxis   • regulation of positive chemotaxis   • positive regulation of response to external stimulus   • taxis   • regulation of locomotion   • locomotion   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to hepatocyte growth factor   • cellular response to growth factor stimulus   • cellular response to hepatocyte growth factor stimulus   • protein localization   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • cellular macromolecule localization   • positive regulation of insulin secretion   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • regulation of protein secretion   • regulation of secretion   • positive regulation of protein localization   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • positive regulation of secretion   • amide transport   • signal release   • positive regulation of peptide secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • detection of stimulus   • response to metal ion   • detection of chemical stimulus   • detection of calcium ion   • response to calcium ion   • presynapse   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse   • somatodendritic compartment   • cell body   • neuronal cell body   • apical part of cell   • apical plasma membrane   • cell surface   • axon   • axon terminus   • distal axon   • neuron projection terminus
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain   • Type 1 solute binding protein-like   • TNF receptor-like
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain   • Type 1 solute binding protein-like   • TNF receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodePCW
PDB ResiduesK:K:?1 W:W:?1
Environment DetailsOpen EMBL-EBI Page
CodePCW
Name(Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide
Synonyms(Z,Z)-4-HYDROXY-N,N,N-TRIMETHYL-10-OXO-7-[(1-OXO-9-OCTADECENYL)OXY]-3,5,9-TRIOXA-4-PHOSPHAHEPTACOS-18-EN-1-AMINIUM-4-OXIDE
Identifier
FormulaC44 H85 N O8 P
Molecular Weight787.121
SMILES
PubChem448653
Formal Charge1
Total Atoms139
Total Chiral Atoms2
Total Bonds138
Total Aromatic Bonds0

CodeCA
PDB ResiduesK:K:?2 K:K:?3 W:W:?2 W:W:?3
Environment DetailsOpen EMBL-EBI Page
CodeCA
NameCALCIUM ION
Synonyms
Identifier
FormulaCa
Molecular Weight40.078
SMILES
PubChem
Formal Charge2
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

CodePO4
PDB ResiduesK:K:?5 W:W:?5
Environment DetailsOpen EMBL-EBI Page
CodePO4
NamePhosphate ion
Synonyms
  • Phosphate
  • Phosphate ion
  • Orthophosphate
Identifier
FormulaO4 P
Molecular Weight94.971
SMILES
PubChem1061
Formal Charge-3
Total Atoms5
Total Chiral Atoms0
Total Bonds4
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41180
Sequence
>8SZI_nogp_Chain_R
YGPDQRAQK KGDIILGGL FPIHFGVAA KDQDLKSRP ESVECIRYN 
FRGFRWLQA MIFAIEEIN SSPALLPNL TLGYRIFDT CNTVSKALE 
ATLSFVAQN KHIPSTIAV VGATGSGVS TAVANLLGL FYIPQVSYA 
SSSRLLSNK NQFKSFLRT IPNDEHQAT AMADIIEYF RWNWVGTIA 
ADDDYGRPG IEKFREEAE ERDICIDFS ELISQYSDE EEIQHVVEV 
IQNSTAKVI VVFSSGPDL EPLIKEIVR RNITGKIWL ASEAWASSS 
LIAMPQYFH VVGGTIGFA LKAGQIPGF REFLKKVHP RKSVHNGFA 
KEFWEETFN CHLQEFRPL CTGDENISS VETPYIDYT HLRISYNVY 
LAVYSIAHA LQDIYTCLP GRGLFTNGS CADIKKVEA WQVLKHLRH 
LNFTNNMGE QVTFDECGD LVGNYSIIN WHLSPEDGS IVFKEVGYY 
NVYAKKGER LFINEEKIL WSGFSREVP FSNCSRDCL AGTRKGIIE 
GEPTCCFEC VECPDGEYS DETDASACN KCPDDFWSN ENHTSCIAK 
EIEFLSWTE PFGIALTLF AVLGIFLTA FVLGVFIKF RNTPIVKAT 
NRELSYLLL FSLLCCFSS SLFFIGEPQ DWTCRLRQP AFGISFVLC 
ISCILVKTN RVLLVFEAK IPTSFHRKW WGLNLQFLL VFLCTFMQI 
VICVIWLYT APPSSYRNQ ELEDEIIFI TCHEGSLMA LGFLIGYTC 
LLAAICFFF AFKSRKLPE NFNEAKFIT FSMLIFFIV WISFIPAYA 
STYGKFVSA VEVIAILAA SFGLLACIF FNKIYIILF KPSRNTIEE 
VRCSTAAHA FKVAARA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP41180
Sequence
>8SZI_nogp_Chain_S
YGPDQRAQK KGDIILGGL FPIHFGVAA KDQDLKSRP ESVECIRYN 
FRGFRWLQA MIFAIEEIN SSPALLPNL TLGYRIFDT CNTVSKALE 
ATLSFVAQN KHIPSTIAV VGATGSGVS TAVANLLGL FYIPQVSYA 
SSSRLLSNK NQFKSFLRT IPNDEHQAT AMADIIEYF RWNWVGTIA 
ADDDYGRPG IEKFREEAE ERDICIDFS ELISQYSDE EEIQHVVEV 
IQNSTAKVI VVFSSGPDL EPLIKEIVR RNITGKIWL ASEAWASSS 
LIAMPQYFH VVGGTIGFA LKAGQIPGF REFLKKVHP RKSVHNGFA 
KEFWEETFN CHLQERPLC TGDENISSV ETPYIDYTH LRISYNVYL 
AVYSIAHAL QDIYTCLPG RGLFTNGSC ADIKKVEAW QVLKHLRHL 
NFTNNMGEQ VTFDECGDL VGNYSIINW HLSPEDGSI VFKEVGYYN 
VYAKKGERL FINEEKILW SGFSREVPF SNCSRDCLA GTRKGIIEG 
EPTCCFECV ECPDGEYSD ETDASACNK CPDDFWSNE NHTSCIAKE 
IEFLSWTEP FGIALTLFA VLGIFLTAF VLGVFIKFR NTPIVKATN 
RELSYLLLF SLLCCFSSS LFFIGEPQD WTCRLRQPA FGISFVLCI 
SCILVKTNR VLLVFEAKN LQFLLVFLC TFMQIVICV IWLYTAPPS 
SYRNQELED EIIFITCHE GSLMALGFL IGYTCLLAA ICFFFAFKS 
RKLPENFNE AKFITFSML IFFIVWISF IPAYASTYG KFVSAVEVI 
AILAASFGL LACIFFNKI YIILFKPSR NTIEEVRCS T


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9C2FCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Tryptophan; '6218; PO4-2.82024-10-0210.1126/science.ado1868
9C1PCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan; '6218; PO4-2.82024-10-0210.1126/science.ado1868
9AXFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.52024-04-1710.1038/s41586-024-07331-1
9AXF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.52024-04-1710.1038/s41586-024-07331-1
9ASBCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.42024-04-1710.1038/s41586-024-07331-1
9ASB (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.42024-04-1710.1038/s41586-024-07331-1
9AVGCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs)/β1/γ23.62024-04-1710.1038/s41586-024-07331-1
9AVG (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-1710.1038/s41586-024-07331-1
9AYFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4Gi1/β1/γ23.62024-04-1710.1038/s41586-024-07331-1
9AYF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-1710.1038/s41586-024-07331-1
9AVLCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4Gi3/β2/γ23.82024-04-1710.1038/s41586-024-07331-1
9AVL (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.82024-04-1710.1038/s41586-024-07331-1
8SZFCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-2.82024-02-0710.1038/s41586-024-07055-2
8SZGCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWchim(NtGi1-Gq)/β1/γ23.62024-02-0710.1038/s41586-024-07055-2
8SZG (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW3.62024-02-0710.1038/s41586-024-07055-2
8SZHCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWGi1/β1/γ23.12024-02-0710.1038/s41586-024-07055-2
8SZH (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW3.12024-02-0710.1038/s41586-024-07055-2
8SZICIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWGi3/β1/γ23.52024-02-0710.1038/s41586-024-07055-2
8SZI (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW3.52024-02-0710.1038/s41586-024-07055-2
8WPGCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca-2.72023-11-2210.1038/s41422-023-00892-2
8WPUCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(NtGi2L-Gs-CtGq)/β1/γ23.12023-11-2210.1038/s41422-023-00892-2
8WPU (No Gprot) CIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca3.12023-11-2210.1038/s41422-023-00892-2
7SINCIonCalcium SensingCaSHomo sapiens-NPS-2143-5.92022-01-1910.1073/pnas.2115849118
7SIMCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-2.72022-01-1910.1073/pnas.2115849118
7SILCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-2.72022-01-1910.1073/pnas.2115849118
7E6UCIonCalcium SensingCaSHomo sapiens---62021-09-2210.7554/eLife.68578
7E6TCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-32021-09-2210.7554/eLife.68578
7M3JCIonCalcium SensingCaSHomo sapiens-NPS-2143; PO4-4.12021-06-3010.1038/s41586-021-03691-0
7M3GCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4-2.52021-06-3010.1038/s41586-021-03691-0
7M3FCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4-2.82021-06-3010.1038/s41586-021-03691-0
7M3ECIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; NPS-2143-3.22021-06-3010.1038/s41586-021-03691-0
7DD7CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; Evocalcet-3.22021-06-1610.1126/sciadv.abg1483
7DD6CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan-3.22021-06-1610.1126/sciadv.abg1483
7DD5CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; NPS-2143-3.22021-06-1610.1126/sciadv.abg1483
7DTWCIonCalcium SensingCaSHomo sapiens---4.52021-03-1010.1038/s41422-021-00474-0
7DTVCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan-3.52021-03-1010.1038/s41422-021-00474-0
7DTUCIonCalcium SensingCaSHomo sapiens-Tryptophan-4.42021-03-1010.1038/s41422-021-00474-0
7DTTCIonCalcium SensingCaSHomo sapiensCaCa-3.82021-03-1010.1038/s41422-021-00474-0




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