Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1H:H:?1 13.6414720
2H:H:?3 15.71176150
3H:H:?5 20.03336160
4H:H:?9 13.25290
5X:X:W4 5.27510
6X:X:?5 8.93610
7R:R:F38 5.072527
8R:R:H41 7.148527
9R:R:F42 8.3854223
10R:R:V44 3.2475422
11R:R:R62 5.1754224
12R:R:Y63 7.09167625
13R:R:F65 5.576522
14R:R:R66 7.8275425
15R:R:F68 6.05833627
16R:R:R69 6.616528
17R:R:W70 8.08625
18R:R:L71 3.356524
19R:R:Q72 5.304527
20R:R:M74 3.08628
21R:R:I75 4.2424
22R:R:F76 6.1775427
23R:R:Y95 6.838528
24R:R:R96 5.42754304
25R:R:I97 3.85833628
26R:R:F98 8.468504
27R:R:D99 6.14429
28R:R:C101 4.89428
29R:R:F114 4.33405
30R:R:T145 4.06833625
31R:R:S147 3.6975428
32R:R:V153 4.51456
33R:R:L157 4.266557
34R:R:I162 3.96406
35R:R:P163 3.7775408
36R:R:Q164 5.04333658
37R:R:Y167 4.23143728
38R:R:R172 4.8975404
39R:R:L173 5.1775405
40R:R:L174 8.105457
41R:R:F180 6.745455
42R:R:F183 7.108558
43R:R:R185 5.52659
44R:R:I187 3.3175406
45R:R:M197 4.1275407
46R:R:I201 3.62406
47R:R:Y203 5.475485
48R:R:F204 8.634587
49R:R:W206 6.48333689
50R:R:W208 6.50333609
51R:R:T211 4.1275405
52R:R:I212 3.3425406
53R:R:Y218 3.87857727
54R:R:I223 4.0475405
55R:R:K225 6.544403
56R:R:F226 3.2075406
57R:R:E229 4.8345405
58R:R:R233 7.24404
59R:R:F239 5.1285176
60R:R:Q260 2.55254185
61R:R:V266 5.348587
62R:R:F270 4.235407
63R:R:P274 3.7065223
64R:R:L276 5.9554135
65R:R:E277 5.7854222
66R:R:L279 4.3275405
67R:R:E282 6.4325186
68R:R:R286 5.5445184
69R:R:L294 3.2825407
70R:R:W299 5.871676137
71R:R:L304 4.4865222
72R:R:I305 4.1645134
73R:R:Y310 4.8625403
74R:R:F320 4.17406
75R:R:I327 4.018526
76R:R:F330 5.11667628
77R:R:F333 5.94427
78R:R:L334 5.93333626
79R:R:V337 2.115425
80R:R:N345 3.1875428
81R:R:F347 3.545625
82R:R:F351 7.68626
83R:R:W352 10.188528
84R:R:T355 6.3775424
85R:R:F356 10.582528
86R:R:H359 1.4775404
87R:R:L360 6.18254444
88R:R:I401 2.348527
89R:R:Y408 6.45723
90R:R:Y411 7.4525425
91R:R:L414 4.1975426
92R:R:R415 5.51405
93R:R:S417 3.434526
94R:R:Y418 6.912527
95R:R:Y421 7.448528
96R:R:W458 9.0354144
97R:R:Q459 5.3745147
98R:R:L461 3.9954397
99R:R:L467 3.5254317
100R:R:F469 10.184318
101R:R:N471 3.536526
102R:R:M473 4.0675424
103R:R:D484 5.582558
104R:R:W494 6.5056137
105R:R:S497 2.8975403
106R:R:I503 4.2554134
107R:R:F505 4.5425134
108R:R:Y511 5.195605
109R:R:N512 6.455424
110R:R:Y514 4.27524
111R:R:L521 3.31485
112R:R:W530 8.17167688
113R:R:T550 2.83254466
114R:R:K552 7.96408
115R:R:C582 5.2954479
116R:R:W590 7.135406
117R:R:C598 4.354339
118R:R:W608 6.0675405
119R:R:L616 5.5625408
120R:R:V630 5.06467
121R:R:V633 4.6525465
122R:R:F634 3.716569
123R:R:F637 4.558564
124R:R:N647 6.3254129
125R:R:R648 4.9075408
126R:R:F662 5.2856198
127R:R:F668 6.25409
128R:R:P672 3.8425479
129R:R:C677 2.89579
130R:R:Q681 7.4475479
131R:R:F684 7.396508
132R:R:R701 6.7154128
133R:R:F706 5.685209
134R:R:H715 6.015125
135R:R:W719 4.9254126
136R:R:Q724 7.80254128
137R:R:Q735 7.54409
138R:R:W742 4.97167679
139R:R:P748 3.26579
140R:R:Y751 8.7654113
141R:R:I761 3.48407
142R:R:F762 8.37754117
143R:R:I763 4.7875477
144R:R:F788 5.4525408
145R:R:L797 3.665208
146R:R:N800 3.5165487
147R:R:F801 5.40754209
148R:R:F806 6.1175405
149R:R:F814 7.12409
150R:R:F815 4.3375407
151R:R:W818 8.3325409
152R:R:F821 4.24833609
153R:R:I841 6.3125409
154R:R:I852 4.955409
155R:R:F853 6.095669
156R:R:I857 5.1125468
157R:R:I860 3.78469
158R:R:L861 3.795465
159R:R:N867 9.8875469
160S:S:G30 1.85754499
161S:S:F38 5.298517
162S:S:H41 6.924517
163S:S:F42 8.34754503
164S:S:P55 5.9254146
165S:S:Y63 6.58615
166S:S:F65 6.026512
167S:S:R66 8.9275415
168S:S:F68 5.13617
169S:S:R69 7.28418
170S:S:W70 7.08333615
171S:S:L71 4.34143714
172S:S:Q72 4.37571717
173S:S:M74 3.416518
174S:S:I75 4.2325414
175S:S:F76 6.3975417
176S:S:L87 4.9625416
177S:S:Y95 6.91408
178S:S:R96 3.63504
179S:S:I97 4.805418
180S:S:F98 7.02534
181S:S:D99 6.2125419
182S:S:C101 6.0625418
183S:S:L112 1.38455
184S:S:F114 3.69635
185S:S:I135 4.895404
186S:S:T145 3.98615
187S:S:V153 4.51436
188S:S:L157 3.702537
189S:S:F160 5.768537
190S:S:I162 3.252536
191S:S:P163 2.545408
192S:S:Q164 6.045438
193S:S:Y167 4.96286718
194S:S:L173 4.5285425
195S:S:L174 7.1275437
196S:S:F180 5.886535
197S:S:F183 5.99167638
198S:S:L184 3.54406
199S:S:R185 6.156539
200S:S:Q193 5.184519
201S:S:I200 3.06418
202S:S:I201 3.334506
203S:S:F204 6.514517
204S:S:W206 6.128519
205S:S:W208 7.252867219
206S:S:T211 4.0875405
207S:S:Y218 4.00286717
208S:S:K225 6.2025403
209S:S:F226 2.6225406
210S:S:E229 5.84754525
211S:S:R233 6.4865524
212S:S:F239 4.8325216
213S:S:V269 4.062515
214S:S:F270 4.7325417
215S:S:S271 3.7025414
216S:S:P274 3.395503
217S:S:D275 3.90754535
218S:S:L276 5.046515
219S:S:I280 3.1225415
220S:S:E282 5.6925356
221S:S:R286 5.0765354
222S:S:W293 5.64418
223S:S:S296 4.625418
224S:S:W299 6.06833617
225S:S:L304 3.77254502
226S:S:I305 3.56514
227S:S:Y310 4.324513
228S:S:F311 6.8625403
229S:S:V313 3.8275403
230S:S:F320 4.83516
231S:S:I327 4.21333616
232S:S:F330 5.116518
233S:S:R331 8.29414
234S:S:F333 6.4975417
235S:S:L334 5.33833616
236S:S:V337 2.782515
237S:S:N345 3.186518
238S:S:F347 4.09833615
239S:S:F351 7.18333616
240S:S:W352 10.85418
241S:S:T355 6.3775414
242S:S:F356 10.4675418
243S:S:L360 4.525404
244S:S:E399 8.1075418
245S:S:Y408 7.31667613
246S:S:I409 3.9625415
247S:S:Y411 7.23415
248S:S:L414 4.9575416
249S:S:R415 6.2875415
250S:S:Y418 5.73417
251S:S:Y421 10.9418
252S:S:Y435 3.39254513
253S:S:F444 3.2354233
254S:S:W458 10.34234
255S:S:Q459 6.985237
256S:S:K462 4.092504
257S:S:L464 3.7375407
258S:S:F469 10.514348
259S:S:N471 5.5425416
260S:S:M473 3.91333614
261S:S:D484 7.0175438
262S:S:W494 6.52617
263S:S:S497 3.10754553
264S:S:D500 3.894554
265S:S:Y511 4.78505
266S:S:N512 7.024294
267S:S:Y514 6.975294
268S:S:L521 4.675415
269S:S:W530 5.14375818
270S:S:C546 4.56254329
271S:S:F563 6.6154327
272S:S:Y573 4.99754246
273S:S:D578 7.40754327
274S:S:T596 2.3175405
275S:S:C598 5.8254249
276S:S:W608 4.0425405
277S:S:G623 3.865496
278S:S:T627 4.022597
279S:S:F634 4.0025409
280S:S:I635 3.0825404
281S:S:I642 4.854547
282S:S:L650 5.73254368
283S:S:L654 3.455408
284S:S:L655 5.1625499
285S:S:L658 3.6575498
286S:S:F662 6.78833698
287S:S:F668 7.8525109
288S:S:P672 4.294109
289S:S:W675 5.13754573
290S:S:R680 7.0825108
291S:S:Q681 6.0145109
292S:S:F684 5.15167648
293S:S:F688 4.31333648
294S:S:V689 3.6054267
295S:S:I695 3.492547
296S:S:Q724 5.414368
297S:S:Q735 5.218336269
298S:S:P747 2.135408
299S:S:Q754 4.354254
300S:S:I763 5.134107
301S:S:C765 5.964109
302S:S:Y779 5.0154269
303S:S:F790 5.01407
304S:S:N800 4.0675447
305S:S:F801 6.7325449
306S:S:E803 4.304549
307S:S:I807 3.33449
308S:S:M811 4.13667649
309S:S:F814 5.264509
310S:S:W818 5.74667649
311S:S:S827 3.5225408
312S:S:V838 4.3975407
313S:S:L848 3.16447
314S:S:F853 4.25699
315S:S:I859 6.9425449
316S:S:K863 15.255447
317W:W:W4 4.35286720
318W:W:?5 8.63833620
319W:W:W6 7.442500
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F270 R:R:S296 38.63913.96YesNo078
2R:R:S296 R:R:W299 86.3882.47NoYes087
3R:R:V269 R:R:W299 96.46788.58NoYes057
4R:R:I212 R:R:V269 96.48913.07YesNo065
5R:R:I212 R:R:I259 97.51722.94YesNo066
6R:R:F239 R:R:I259 97.53792.51YesNo066
7R:R:D238 R:R:F239 98.47693.58NoYes1786
8R:R:D238 R:R:W208 98.542414.52NoYes089
9R:R:C236 R:R:W208 98.72372.61NoYes099
10R:R:C236 R:R:C561 98.78377.28NoNo099
11R:R:C561 R:R:N207 98.80376.3NoNo096
12H:H:?3 R:R:N207 98.74819.86YesNo1506
13H:H:?3 R:R:D545 98.89239.74YesNo005
14R:R:F270 R:R:I223 29.55262.51YesYes075
15R:R:E224 R:R:I223 29.43942.73NoYes065
16R:R:E224 S:S:E224 29.387910.15NoNo066
17S:S:E224 S:S:R227 29.33718.14NoNo064
18S:S:I237 S:S:R227 29.24432.51NoNo064
19S:S:I237 S:S:T211 29.19813.04NoYes065
20S:S:F226 S:S:T211 28.96822.59YesYes065
21S:S:F226 S:S:I201 10.32252.51YesYes066
22R:R:L156 R:R:T111 15.20485.9NoNo557
23R:R:L156 S:S:L112 14.98471.38NoYes555
24S:S:L112 S:S:L156 15.41391.38YesNo055
25S:S:L156 S:S:T111 15.32141.47NoNo057
26S:S:L157 S:S:T111 12.1682.95YesNo377
27S:S:I162 S:S:L157 13.55884.28YesYes367
28S:S:I162 S:S:P163 13.23023.39YesYes068
29R:R:L157 R:R:Q164 10.35656.65YesYes578
30S:S:Y218 X:X:W4 13.7973.86YesYes170
31S:S:F226 S:S:V268 18.56762.62YesNo066
32S:S:M197 S:S:V268 18.46823.04NoNo076
33S:S:F270 S:S:M197 18.42026.22YesNo077
34S:S:F270 S:S:Y218 12.70963.09YesYes177
35R:R:L34 R:R:M74 12.89112.83NoYes078
36R:R:L34 R:R:L93 11.62094.15NoNo079
37R:R:S147 R:R:S169 22.68653.26YesNo088
38R:R:S296 R:R:Y218 54.5145.09NoYes087
39R:R:Y218 W:W:W4 30.97833.86YesYes270
40R:R:Q164 R:R:S150 20.18482.89YesNo088
41R:R:D545 R:R:D578 98.91210.65NoNo057
42R:R:D578 R:R:K552 98.951511.06NoYes078
43R:R:G553 R:R:K552 99.20561.74NoYes068
44R:R:G553 R:R:V566 99.22491.84NoNo064
45R:R:R551 R:R:V566 99.244310.46NoNo074
46R:R:C582 R:R:R551 99.79595.57YesNo097
47R:R:C568 R:R:C582 99.87047.28NoYes099
48R:R:C568 R:R:H595 99.92612.95NoNo095
49R:R:H595 R:R:S591 99.96315.58NoNo058
50R:R:G571 R:R:S591 99.98163.71NoNo078
51R:R:G571 R:R:W590 1008.44NoYes076
52R:R:K601 R:R:W590 99.7033.48NoYes086
53R:R:I761 R:R:K601 99.7215.82YesNo078
54R:R:I603 R:R:I761 49.92672.94NoYes047
55R:R:I603 R:R:I763 49.99882.94NoYes047
56R:R:I761 R:R:R752 49.84863.76YesNo073
57R:R:I763 R:R:R752 49.84465.01YesNo073
58R:R:I763 R:R:P672 99.76088.47YesYes779
59R:R:C677 R:R:P672 99.70061.88YesYes799
60R:R:C677 R:R:P748 99.75051.88YesYes799
61R:R:P748 R:R:W742 51.18876.76YesYes799
62R:R:Q681 R:R:W742 48.41754.38YesYes799
63R:R:Q681 W:W:W6 96.49083.29YesYes090
64R:R:F684 W:W:W6 19.542411.02YesYes080
65R:R:E767 R:R:P748 48.4093.14NoYes779
66R:R:E767 R:R:Q681 48.367111.47NoYes779
67R:R:W818 W:W:W6 72.218112.18YesYes090
68R:R:C661 R:R:F684 16.95962.79NoYes078
69R:R:C661 R:R:S845 16.48763.44NoNo078
70R:R:F662 R:R:S845 16.36977.93YesNo088
71R:R:F662 R:R:L658 15.45522.44YesNo1988
72R:R:L658 R:R:L849 15.39235.54NoNo088
73R:R:F853 R:R:L849 14.80884.87YesNo098
74R:R:A840 R:R:W818 64.13547.78NoYes099
75R:R:A840 R:R:F821 64.03452.77NoYes099
76R:R:F821 S:S:A824 62.92732.77YesNo097
77R:R:S820 S:S:A824 62.82821.71NoNo077
78R:R:S820 S:S:S820 62.72953.26NoNo077
79R:R:I816 S:S:S820 62.6313.1NoNo087
80R:R:I816 S:S:V817 62.92294.61NoNo089
81S:S:V817 S:S:W818 62.72083.68NoYes099
82S:S:F684 S:S:W818 37.1165.01YesYes489
83S:S:F684 S:S:F688 24.137.5YesYes488
84S:S:F688 S:S:I692 13.46235.02YesNo487
85S:S:I692 S:S:M811 13.24682.92NoYes479
86S:S:F814 S:S:W818 24.60310.02YesYes099
87S:S:F688 S:S:F814 23.97115.36YesYes089
88S:S:F684 S:S:I841 10.613610.05YesNo089
89S:S:F668 S:S:I841 10.50452.51YesNo099
90S:S:F688 S:S:L848 29.23192.44YesYes487
91S:S:I695 S:S:L848 28.36762.85YesYes477
92S:S:I695 S:S:I852 12.13814.42YesNo079
93S:S:E803 S:S:I807 11.28622.73YesYes499
94S:S:E803 S:S:N800 14.99965.26YesYes497
95S:S:F801 S:S:N800 13.69852.42YesYes497
96R:R:R66 W:W:W4 13.44723YesYes250
97R:R:T145 W:W:W4 11.15236.06YesYes250
98R:R:S147 R:R:Y218 21.43822.54YesYes287
99R:R:S150 R:R:S169 20.31256.52NoNo088
100R:R:I32 R:R:L93 10.35274.28NoNo069
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8SZI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.34
Number of Linked Nodes 1551
Number of Links 1932
Number of Hubs 319
Number of Links mediated by Hubs 1148
Number of Communities 58
Number of Nodes involved in Communities 492
Number of Links involved in Communities 710
Path Summary
Number Of Nodes in MetaPath 101
Number Of Links MetaPath 100
Number of Shortest Paths 10627947
Length Of Smallest Path 3
Average Path Length 53.385
Length of Longest Path 90
Minimum Path Strength 1.18
Average Path Strength 4.87929
Maximum Path Strength 32.56
Minimum Path Correlation 0.7
Average Path Correlation 0.999256
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.92308
Average % Of Corr. Nodes 59.2118
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.4466
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • GDP binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • cation binding   • metal ion binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular process   • cell division   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • regulation of molecular function   • regulation of adenylate cyclase activity
Gene OntologyBiological Process• cellular process   • cell division   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • regulation of molecular function   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • positive regulation of autophagy   • catabolic process   • macroautophagy   • autophagy   • positive regulation of biological process   • regulation of catabolic process   • regulation of autophagy   • positive regulation of catabolic process   • positive regulation of metabolic process   • regulation of macroautophagy   • metabolic process   • positive regulation of macroautophagy   • process utilizing autophagic mechanism   • regulation of metabolic process   • positive regulation of cellular process   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • nucleoside phosphate metabolic process   • ribose phosphate metabolic process   • purine nucleoside triphosphate metabolic process   • GTP metabolic process   • carbohydrate derivative metabolic process   • primary metabolic process   • nucleotide metabolic process   • purine-containing compound metabolic process   • nucleobase-containing compound metabolic process   • purine nucleotide metabolic process   • ribonucleotide metabolic process   • organophosphate metabolic process   • nucleobase-containing small molecule metabolic process   • purine ribonucleoside triphosphate metabolic process   • phosphate-containing compound metabolic process   • small molecule metabolic process   • nucleoside triphosphate metabolic process   • purine ribonucleotide metabolic process   • phosphorus metabolic process   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytoplasm   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • amino acid binding   • identical protein binding   • cation binding   • ion binding   • calcium ion binding   • metal ion binding   • small molecule binding   • phosphoric ester hydrolase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • phospholipase C activity   • phosphatidylinositol-4,5-bisphosphate phospholipase C activity   • phospholipase activity   • lipase activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • transmembrane transporter binding   • cell adhesion molecule binding   • integrin binding   • signaling receptor binding   • protein homodimerization activity   • protein dimerization activity   • kinase binding   • protein kinase binding   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • epithelium development   • tube development   • branching morphogenesis of an epithelial tube   • morphogenesis of an epithelium   • tissue development   • tissue morphogenesis   • anatomical structure morphogenesis   • tube morphogenesis   • morphogenesis of a branching structure   • epithelial tube morphogenesis   • morphogenesis of a branching epithelium   • regulation of tube diameter   • regulation of tube size   • regulation of system process   • positive regulation of biological process   • positive regulation of vasoconstriction   • circulatory system process   • regulation of blood circulation   • vascular process in circulatory system   • regulation of vasoconstriction   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • blood vessel diameter maintenance   • vasoconstriction   • blood circulation   • regulation of anatomical structure size   • monoatomic ion transmembrane transport   • chloride transport   • transmembrane transport   • chloride transmembrane transport   • monoatomic anion transport   • monoatomic anion transmembrane transport   • inorganic anion transport   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • response to stress   • response to ischemia   • response to decreased oxygen levels   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to stress   • response to hypoxia   • response to oxygen levels   • response to abiotic stimulus   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • organic acid transport   • bile acid secretion   • organic anion transport   • monocarboxylic acid transport   • carboxylic acid transport   • secretion   • acid secretion   • response to peptide   • cellular response to peptide   • behavior   • chemosensory behavior   • JNK cascade   • MAPK cascade   • cellular response to low-density lipoprotein particle stimulus   • response to lipoprotein particle   • cellular response to lipoprotein particle stimulus   • regulation of calcium ion import   • positive regulation of calcium ion transport   • positive regulation of calcium ion import   • positive regulation of transport   • positive regulation of monoatomic ion transport   • calcium ion import   • ossification   • connective tissue development   • adipose tissue development   • fat pad development   • response to fibroblast growth factor   • response to growth factor   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • cellular response to glucose stimulus   • intracellular glucose homeostasis   • response to hexose   • cellular response to carbohydrate stimulus   • response to monosaccharide   • response to carbohydrate   • response to glucose   • glucose homeostasis   • carbohydrate homeostasis   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • response to nutrient levels   • response to nutrient   • response to vitamin   • cellular response to vitamin D   • cellular response to nutrient levels   • response to vitamin D   • cellular response to vitamin   • cellular response to nutrient   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • vasodilation   • positive chemotaxis   • chemotaxis   • positive regulation of locomotion   • regulation of response to external stimulus   • positive regulation of positive chemotaxis   • response to external stimulus   • regulation of chemotaxis   • positive regulation of chemotaxis   • regulation of positive chemotaxis   • positive regulation of response to external stimulus   • taxis   • regulation of locomotion   • locomotion   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to hepatocyte growth factor   • cellular response to growth factor stimulus   • cellular response to hepatocyte growth factor stimulus   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • positive regulation of insulin secretion   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • regulation of protein secretion   • regulation of secretion   • positive regulation of protein localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • positive regulation of secretion   • amide transport   • signal release   • positive regulation of peptide secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • detection of stimulus   • response to metal ion   • detection of chemical stimulus   • detection of calcium ion   • response to calcium ion   • presynapse   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse   • somatodendritic compartment   • cell body   • neuronal cell body   • apical part of cell   • apical plasma membrane   • cell surface   • axon   • axon terminus   • distal axon   • neuron projection terminus
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain   • Type 1 solute binding protein-like   • TNF receptor-like
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain   • Type 1 solute binding protein-like   • TNF receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8 H:H:?9
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylglucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodeCA
PDB ResiduesX:X:?2 X:X:?3 W:W:?2 W:W:?3
Environment DetailsOpen EMBL-EBI Page
CodeCA
NameCALCIUM ION
Synonyms
Identifier
FormulaCa
Molecular Weight40.078
SMILES
PubChem
Formal Charge2
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

CodePO4
PDB ResiduesX:X:?5 W:W:?5
Environment DetailsOpen EMBL-EBI Page
CodePO4
NamePhosphate ion
Synonyms
  • Orthophosphate
  • Phosphate ion
  • Phosphate
Identifier
FormulaO4 P
Molecular Weight94.971
SMILES
PubChem1061
Formal Charge-3
Total Atoms5
Total Chiral Atoms0
Total Bonds4
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41180
Sequence
>8SZI_nogp_Chain_R
YGPDQRAQK KGDIILGGL FPIHFGVAA KDQDLKSRP ESVECIRYN 
FRGFRWLQA MIFAIEEIN SSPALLPNL TLGYRIFDT CNTVSKALE 
ATLSFVAQN KHIPSTIAV VGATGSGVS TAVANLLGL FYIPQVSYA 
SSSRLLSNK NQFKSFLRT IPNDEHQAT AMADIIEYF RWNWVGTIA 
ADDDYGRPG IEKFREEAE ERDICIDFS ELISQYSDE EEIQHVVEV 
IQNSTAKVI VVFSSGPDL EPLIKEIVR RNITGKIWL ASEAWASSS 
LIAMPQYFH VVGGTIGFA LKAGQIPGF REFLKKVHP RKSVHNGFA 
KEFWEETFN CHLQEFRPL CTGDENISS VETPYIDYT HLRISYNVY 
LAVYSIAHA LQDIYTCLP GRGLFTNGS CADIKKVEA WQVLKHLRH 
LNFTNNMGE QVTFDECGD LVGNYSIIN WHLSPEDGS IVFKEVGYY 
NVYAKKGER LFINEEKIL WSGFSREVP FSNCSRDCL AGTRKGIIE 
GEPTCCFEC VECPDGEYS DETDASACN KCPDDFWSN ENHTSCIAK 
EIEFLSWTE PFGIALTLF AVLGIFLTA FVLGVFIKF RNTPIVKAT 
NRELSYLLL FSLLCCFSS SLFFIGEPQ DWTCRLRQP AFGISFVLC 
ISCILVKTN RVLLVFEAK IPTSFHRKW WGLNLQFLL VFLCTFMQI 
VICVIWLYT APPSSYRNQ ELEDEIIFI TCHEGSLMA LGFLIGYTC 
LLAAICFFF AFKSRKLPE NFNEAKFIT FSMLIFFIV WISFIPAYA 
STYGKFVSA VEVIAILAA SFGLLACIF FNKIYIILF KPSRNTIEE 
VRCSTAAHA FKVAARA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP41180
Sequence
>8SZI_nogp_Chain_S
YGPDQRAQK KGDIILGGL FPIHFGVAA KDQDLKSRP ESVECIRYN 
FRGFRWLQA MIFAIEEIN SSPALLPNL TLGYRIFDT CNTVSKALE 
ATLSFVAQN KHIPSTIAV VGATGSGVS TAVANLLGL FYIPQVSYA 
SSSRLLSNK NQFKSFLRT IPNDEHQAT AMADIIEYF RWNWVGTIA 
ADDDYGRPG IEKFREEAE ERDICIDFS ELISQYSDE EEIQHVVEV 
IQNSTAKVI VVFSSGPDL EPLIKEIVR RNITGKIWL ASEAWASSS 
LIAMPQYFH VVGGTIGFA LKAGQIPGF REFLKKVHP RKSVHNGFA 
KEFWEETFN CHLQERPLC TGDENISSV ETPYIDYTH LRISYNVYL 
AVYSIAHAL QDIYTCLPG RGLFTNGSC ADIKKVEAW QVLKHLRHL 
NFTNNMGEQ VTFDECGDL VGNYSIINW HLSPEDGSI VFKEVGYYN 
VYAKKGERL FINEEKILW SGFSREVPF SNCSRDCLA GTRKGIIEG 
EPTCCFECV ECPDGEYSD ETDASACNK CPDDFWSNE NHTSCIAKE 
IEFLSWTEP FGIALTLFA VLGIFLTAF VLGVFIKFR NTPIVKATN 
RELSYLLLF SLLCCFSSS LFFIGEPQD WTCRLRQPA FGISFVLCI 
SCILVKTNR VLLVFEAKN LQFLLVFLC TFMQIVICV IWLYTAPPS 
SYRNQELED EIIFITCHE GSLMALGFL IGYTCLLAA ICFFFAFKS 
RKLPENFNE AKFITFSML IFFIVWISF IPAYASTYG KFVSAVEVI 
AILAASFGL LACIFFNKI YIILFKPSR NTIEEVRCS T


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WPGCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca-2.72023-11-22doi.org/10.1038/s41422-023-00892-2
8WPUCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(NtGi2L-Gs-CtGq)/β1/γ23.12023-11-22doi.org/10.1038/s41422-023-00892-2
8WPU (No Gprot) CIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca3.12023-11-22doi.org/10.1038/s41422-023-00892-2
7DTUCIonCalcium SensingCaSHomo sapiens-Tryptophan-4.42021-03-10doi.org/10.1038/s41422-021-00474-0
7M3JCIonCalcium SensingCaSHomo sapiens-NPS-2143; PO4-4.12021-06-30doi.org/10.1038/s41586-021-03691-0
7SINCIonCalcium SensingCaSHomo sapiens-NPS-2143-5.92022-01-19doi.org/10.1073/pnas.2115849118
9C1PCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan; '6218; PO4-2.82024-10-02doi.org/10.1126/science.ado1868
7DTVCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan-3.52021-03-10doi.org/10.1038/s41422-021-00474-0
7M3ECIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; NPS-2143-3.22021-06-30doi.org/10.1038/s41586-021-03691-0
7DD5CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; NPS-2143-3.22021-06-16doi.org/10.1126/sciadv.abg1483
7M3GCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4-2.52021-06-30doi.org/10.1038/s41586-021-03691-0
7DD7CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; Evocalcet-3.22021-06-16doi.org/10.1126/sciadv.abg1483
8SZFCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-2.82024-02-07doi.org/10.1038/s41586-024-07055-2
8SZGCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Sperminechim(NtGi1-Gq)/β1/γ23.62024-02-07doi.org/10.1038/s41586-024-07055-2
8SZG (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine3.62024-02-07doi.org/10.1038/s41586-024-07055-2
8SZHCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; SpermineGi1/β1/γ23.12024-02-07doi.org/10.1038/s41586-024-07055-2
8SZH (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine3.12024-02-07doi.org/10.1038/s41586-024-07055-2
7M3FCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4-2.82021-06-30doi.org/10.1038/s41586-021-03691-0
8SZICIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4Gi3/β1/γ23.52024-02-07doi.org/10.1038/s41586-024-07055-2
8SZI (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO43.52024-02-07doi.org/10.1038/s41586-024-07055-2
9C2FCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Tryptophan; '54149; PO4-2.82024-10-02doi.org/10.1126/science.ado1868
7DD6CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan-3.22021-06-16doi.org/10.1126/sciadv.abg1483
7SIMCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-2.72022-01-19doi.org/10.1073/pnas.2115849118
7E6TCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-32021-09-22doi.org/10.7554/eLife.68578
9ASBCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.42024-04-17doi.org/10.1038/s41586-024-07331-1
9ASB (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.42024-04-17doi.org/10.1038/s41586-024-07331-1
9AVGCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs)/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AVG (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AVLCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4Gi3/β2/γ23.82024-04-17doi.org/10.1038/s41586-024-07331-1
9AVL (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.82024-04-17doi.org/10.1038/s41586-024-07331-1
9AXFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.52024-04-17doi.org/10.1038/s41586-024-07331-1
9AXF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.52024-04-17doi.org/10.1038/s41586-024-07331-1
9AYFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4Gi1/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AYF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-17doi.org/10.1038/s41586-024-07331-1
7SILCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-2.72022-01-19doi.org/10.1073/pnas.2115849118
7DTTCIonCalcium SensingCaSHomo sapiensCaCa-3.82021-03-10doi.org/10.1038/s41422-021-00474-0
7DTWCIonCalcium SensingCaSHomo sapiens---4.52021-03-10doi.org/10.1038/s41422-021-00474-0
7E6UCIonCalcium SensingCaSHomo sapiens---62021-09-22doi.org/10.7554/eLife.68578




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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