Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1S:S:F38 6.075417
2S:S:P39 5.8125416
3S:S:I40 5.9475415
4S:S:H41 6.58617
5S:S:L51 5.5025496
6S:S:P55 8.47496
7S:S:R62 4.9075464
8S:S:Y63 5.85286715
9S:S:F65 6.68412
10S:S:R66 8.50333615
11S:S:F68 8.11517
12S:S:R69 8.2025418
13S:S:W70 7.1725815
14S:S:L71 4.3875414
15S:S:Q72 5.772517
16S:S:M74 4.246518
17S:S:I75 3.955414
18S:S:I81 6.6275409
19S:S:Y95 8.7125408
20S:S:R96 6.0725404
21S:S:I97 4.692508
22S:S:F98 5.461676284
23S:S:D99 6.825419
24S:S:L112 4.894165
25S:S:F114 4.3345285
26S:S:T145 4.30667615
27S:S:V153 4.905476
28S:S:L157 4.584577
29S:S:F160 6.6407
30S:S:P163 3.4508
31S:S:Q164 5.034578
32S:S:Y167 5.95518
33S:S:S169 4.1325408
34S:S:R172 6.35254474
35S:S:L173 4.2845475
36S:S:L174 6.215477
37S:S:S175 4.4375478
38S:S:F180 6.69475
39S:S:F183 8.3225478
40S:S:R185 6.396579
41S:S:D190 7.07418
42S:S:Q193 5.5425409
43S:S:T195 5.2754294
44S:S:W206 8.1875439
45S:S:W208 8.046509
46S:S:V209 4.0425438
47S:S:T211 4.5075405
48S:S:I212 2.91754206
49S:S:Y218 7.08286717
50S:S:K225 6.27754293
51S:S:R227 5.076504
52S:S:R233 7.055294
53S:S:F239 5.034196
54S:S:V266 5.94437
55S:S:F270 7.096517
56S:S:P274 3.515403
57S:S:L276 6.5925465
58S:S:L279 4.32754205
59S:S:E282 6.8345356
60S:S:W299 7.044567
61S:S:S302 3.8325465
62S:S:L304 5.522562
63S:S:I305 4.155664
64S:S:Y310 9.24754143
65S:S:F311 6.6825403
66S:S:H312 8.1154143
67S:S:V313 4.90254143
68S:S:F320 5.88406
69S:S:I327 4.5825416
70S:S:F330 5.22508
71S:S:L334 7.685416
72S:S:H338 8.15114
73S:S:N345 3.36125818
74S:S:F347 4.51415
75S:S:F351 8.77667616
76S:S:W352 9.816676118
77S:S:F356 9.5225118
78S:S:L360 6.645404
79S:S:C395 5.5454119
80S:S:E399 6.74118
81S:S:Y408 7.96333613
82S:S:L414 6.12516
83S:S:I416 7.59514
84S:S:Y418 7.54429717
85S:S:Y421 8.88518
86S:S:Q432 5.634457
87S:S:F444 4.6685123
88S:S:W458 10.3225124
89S:S:Q459 7.645127
90S:S:L461 4.614467
91S:S:K462 5.615404
92S:S:H463 6.0225405
93S:S:F469 11.31408
94S:S:N471 6.805416
95S:S:C482 4.0325477
96S:S:D484 8.556578
97S:S:W494 6.70333667
98S:S:S497 5.71254363
99S:S:D500 4.344364
100S:S:I503 4.37464
101S:S:Y511 6.26505
102S:S:N512 7.3145174
103S:S:V513 5.74754173
104S:S:Y514 7.0985174
105S:S:I523 4.585436
106S:S:I528 5.086537
107S:S:W530 8.05667638
108S:S:C546 4.174219
109S:S:K552 9.2454218
110S:S:F563 10.024217
111S:S:Y573 6.2454306
112S:S:T596 2.605405
113S:S:C598 4.7154309
114S:S:E610 4.1525407
115S:S:F612 5.2775408
116S:S:V633 4.765405
117S:S:L654 4.356508
118S:S:L658 3.56408
119S:S:F662 5.9785528
120S:S:F668 10.495409
121S:S:I669 3.04408
122S:S:E671 8.814224
123S:S:R678 6.36405
124S:S:Q681 7.63754109
125S:S:F684 8.538336108
126S:S:F688 4.725608
127S:S:C694 3.538506
128S:S:Q724 8.37254548
129S:S:Q735 5.5625329
130S:S:W742 5.216676109
131S:S:I760 9.05754515
132S:S:I761 7.0275407
133S:S:F762 6.6754517
134S:S:L773 5.1365108
135S:S:Y779 5.0865329
136S:S:E803 5.374539
137S:S:F814 6.354509
138S:S:W818 8.426109
139S:S:F821 6.20254109
140S:S:L848 3.8425407
141S:S:F853 6.7056319
142R:R:I32 3.6425496
143R:R:F38 6.545427
144R:R:P39 5.976526
145R:R:H41 6.588527
146R:R:F42 7.47403
147R:R:V44 3.2475422
148R:R:P55 8.494126
149R:R:C60 5.2675427
150R:R:Y63 5.57571725
151R:R:F65 7.2775422
152R:R:R66 9.418525
153R:R:F68 7.868527
154R:R:R69 5.57333628
155R:R:W70 7.1825
156R:R:L71 4.6775404
157R:R:M74 4.896528
158R:R:I75 4.56404
159R:R:L88 5.1225409
160R:R:L93 4.5375409
161R:R:Y95 9.6225408
162R:R:R96 6.5725374
163R:R:I97 6.6575428
164R:R:F98 7.376374
165R:R:C101 5.206528
166R:R:L112 4.19254165
167R:R:F114 3.7785375
168R:R:K119 6.806676163
169R:R:I135 2.9925404
170R:R:T145 4.95625
171R:R:V153 4.51456
172R:R:L156 3.605405
173R:R:L157 4.832557
174R:R:F160 5.5365167
175R:R:P163 4.102508
176R:R:Q164 5.334558
177R:R:Y167 6.31167628
178R:R:R172 6.19454
179R:R:L173 5.314555
180R:R:L174 8.0425457
181R:R:F180 6.582555
182R:R:L184 3.0825406
183R:R:R185 6.73659
184R:R:I187 3.494506
185R:R:Q193 5.371676239
186R:R:W206 7.69589
187R:R:W208 6.89857749
188R:R:V209 4.0575488
189R:R:T211 4.8875405
190R:R:I212 3.7275406
191R:R:Y218 7.368527
192R:R:K225 6.544573
193R:R:E229 7.1645575
194R:R:R233 7.206504
195R:R:F239 5.4075446
196R:R:V255 4.7925445
197R:R:V266 6.7425487
198R:R:F270 5.495407
199R:R:E282 7.8885396
200R:R:R286 6.55254394
201R:R:S302 3.83254335
202R:R:L304 4.564502
203R:R:I305 3.46254334
204R:R:F311 9.1575403
205R:R:V313 4.15754593
206R:R:F320 6.3945236
207R:R:I327 4.325406
208R:R:F330 6.444528
209R:R:L334 7.7775426
210R:R:H338 9.37404
211R:R:N345 2.99167608
212R:R:F347 6405
213R:R:F351 9.746526
214R:R:W352 10.30176248
215R:R:L360 5.2585244
216R:R:E399 8.34754248
217R:R:Y408 7.74667623
218R:R:Y411 8.3325425
219R:R:L414 4.6875426
220R:R:S417 4.7675426
221R:R:Y418 6.495137
222R:R:Y421 8.2954388
223R:R:Y425 8.4825388
224R:R:Q432 6.314567
225R:R:Y435 6.74254563
226R:R:F444 3.94593
227R:R:I452 4.72403
228R:R:W458 9.7594
229R:R:Q459 7.5597
230R:R:L461 5.93497
231R:R:F469 8.8145138
232R:R:N471 5.0165136
233R:R:M473 4.4045134
234R:R:D484 6.855458
235R:R:I491 2.885408
236R:R:W494 6.6325407
237R:R:S497 2.495403
238R:R:I503 5.10754404
239R:R:N512 8.254424
240R:R:Y514 7.4785424
241R:R:I528 6.36487
242R:R:W530 8.47833688
243R:R:R551 7.8525407
244R:R:K552 6.465408
245R:R:G571 3.8825407
246R:R:S591 3.18254628
247R:R:F605 5.3454437
248R:R:W608 6.655405
249R:R:E610 6.065407
250R:R:T627 4.335407
251R:R:L631 4.44254
252R:R:T640 6.2554659
253R:R:L650 5.1725158
254R:R:L654 3.73254268
255R:R:L655 6.634259
256R:R:F662 5.7425648
257R:R:I669 5.2625638
258R:R:R678 4.925405
259R:R:Q681 5.6085279
260R:R:F684 10.1075408
261R:R:F688 4.5825408
262R:R:V689 4.64754447
263R:R:C691 2.94268
264R:R:I695 35267
265R:R:V697 2.63754158
266R:R:F706 5.3354669
267R:R:W719 3.4225676
268R:R:T732 3.556507
269R:R:W742 6.172509
270R:R:I760 5.45345
271R:R:I761 5.4075407
272R:R:F762 4.091676347
273R:R:I763 4.93754437
274R:R:L773 3.34278
275R:R:L776 4.37408
276R:R:Y779 7.3854449
277R:R:L797 2.79754668
278R:R:V817 1.91409
279R:R:F821 5.3025409
280R:R:P823 3.3409
281R:R:K831 6.4025409
282R:R:F853 8.464259
283R:R:K856 5.27754159
284H:H:?1 18.58836170
285H:H:?3 14.06176180
286H:H:?5 22.4265420
287H:H:?7 17.5617640
288X:X:?1 7.10875810
289X:X:?2 9.8710
290I:I:?6 6.3775410
291X:X:?3 9.05512100
292W:W:?1 7.95714720
293W:W:?2 9.4720
294I:I:?2 6.3775420
295W:W:?3 9.94810270
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1S:S:T145 S:S:Y167 10.644.99YesYes158
2I:I:?6 S:S:T145 10.30735.42YesYes105
3I:I:?6 S:S:T100 12.05358.13YesNo007
4S:S:L37 S:S:T100 11.9464.42NoNo067
5S:S:L37 S:S:V153 11.89562.98NoYes066
6R:R:L51 S:S:K462 11.7575.64NoYes064
7R:R:L51 S:S:L461 12.16084.15NoYes4667
8S:S:L461 S:S:P163 13.77974.93YesYes078
9S:S:I162 S:S:P163 16.21473.39NoYes068
10S:S:I162 S:S:L157 16.61145.71NoYes067
11S:S:R66 X:X:?1 14.49355.24YesYes150
12S:S:S147 X:X:?1 12.68335.4NoYes080
13S:S:S147 S:S:S169 13.3633.26NoYes088
14S:S:S150 S:S:S169 11.39956.52NoYes088
15S:S:Q164 S:S:S150 11.39392.89YesNo088
16R:R:L157 R:R:T111 16.48762.95YesNo577
17R:R:L156 R:R:T111 53.63165.9YesNo057
18R:R:L156 S:S:L112 48.04022.77YesYes055
19S:S:L112 S:S:L156 47.80332.77YesNo055
20S:S:L156 S:S:T111 46.57485.9NoNo057
21S:S:L157 S:S:T111 28.6312.95YesNo777
22S:S:D190 S:S:S170 12.74138.83YesNo087
23S:S:S170 X:X:?1 12.81947.56NoYes070
24S:S:D190 S:S:Y218 12.85595.75YesYes187
25S:S:Y218 X:X:?1 26.138216.86YesYes170
26R:R:T145 W:W:?1 14.02735.3YesYes250
27I:I:?2 R:R:T145 17.17795.42YesYes205
28I:I:?2 R:R:T100 26.20948.13YesNo007
29R:R:L37 R:R:T100 26.15354.42NoNo067
30R:R:L37 R:R:V153 25.09972.98NoYes066
31R:R:T111 R:R:V153 37.4836.35NoYes576
32S:S:D190 S:S:Q193 25.49676.53YesYes089
33S:S:S296 S:S:Y218 12.85583.82NoYes187
34S:S:Q193 S:S:S296 12.85232.89YesNo098
35S:S:F320 S:S:Q193 37.83889.37YesYes069
36S:S:F320 S:S:M197 32.14136.22YesNo067
37S:S:M197 S:S:V268 25.12753.04NoNo376
38S:S:F226 S:S:T211 27.68132.59NoYes065
39S:S:F226 S:S:V268 27.72299.18NoNo066
40S:S:I237 S:S:T211 27.55754.56NoYes065
41R:R:F183 R:R:R185 30.77697.48NoYes589
42R:R:F183 R:R:Q164 30.71377.03NoYes588
43R:R:Q164 R:R:V153 13.31655.73YesYes586
44R:R:L157 R:R:Q164 17.567.99YesYes578
45S:S:I237 S:S:R227 27.53512.51NoYes064
46R:R:R227 S:S:R227 27.45864.26NoYes044
47R:R:D238 R:R:W208 99.883313.4NoYes489
48R:R:D238 R:R:F239 1003.58NoYes486
49R:R:F239 R:R:G210 98.84357.53YesNo068
50R:R:G210 R:R:V209 98.97143.68NoYes088
51R:R:I201 R:R:V209 36.663.07NoYes868
52R:R:I201 R:R:W206 38.44174.7NoYes869
53R:R:F204 R:R:W206 37.108814.03NoYes879
54R:R:F204 R:R:Y203 37.08356.19NoNo075
55R:R:L521 R:R:Y203 37.12113.52NoNo055
56R:R:I200 R:R:L521 37.13282.85NoNo2385
57R:R:F320 R:R:I200 37.28933.77YesNo2368
58R:R:F320 R:R:Q193 75.910311.71YesYes2369
59R:R:D190 R:R:Q193 20.29385.22NoYes089
60R:R:D190 R:R:S170 20.29788.83NoNo087
61R:R:I187 R:R:S170 24.71454.64YesNo067
62R:R:I187 R:R:R185 42.61523.76YesYes069
63R:R:V209 R:R:V266 37.16466.41YesYes887
64R:R:V266 R:R:W206 36.71611.03YesYes879
65R:R:W206 R:R:W530 38.10353.75YesYes898
66R:R:I528 R:R:W530 38.28410.57YesYes878
67R:R:I528 R:R:V508 38.34267.68YesNo077
68R:R:I491 R:R:V508 38.39653.07YesNo087
69R:R:F320 R:R:I491 38.60953.77YesYes068
70R:R:E297 R:R:Q193 55.98523.82NoYes089
71R:R:E297 R:R:L322 19.881310.6NoNo084
72R:R:I187 R:R:L322 19.85472.85YesNo064
73R:R:E297 W:W:?1 36.12555.72NoYes080
74S:S:P274 S:S:Q245 10.10053.16YesNo034
75S:S:Q245 S:S:Y246 10.387614.65NoNo043
76R:R:N176 R:R:N178 11.00456.81NoNo063
77R:R:N176 R:R:Q179 11.11653.96NoNo065
78R:R:F180 R:R:Q179 11.231616.4YesNo055
79R:R:K552 S:S:I554 94.73331.45YesNo083
80R:R:D578 R:R:K552 95.95162.77NoYes078
81R:R:D545 R:R:D578 96.35689.31NoNo057
82H:H:?7 R:R:D545 96.491812.18YesNo005
83H:H:?7 R:R:N207 97.149513.55YesNo406
84R:R:C561 R:R:N207 97.73737.87NoNo496
85R:R:C236 R:R:C561 97.83877.28NoNo499
86R:R:C236 R:R:W208 98.2752.61NoYes499
87S:S:E610 S:S:S607 10.16744.31YesNo077
88S:S:F605 S:S:S607 10.50312.64NoNo077
89S:S:E671 S:S:F605 10.670915.16YesNo047
90S:S:E671 S:S:P672 11.32793.14YesNo2249
91S:S:P672 S:S:R680 12.84762.88NoNo098
92S:S:F668 S:S:R680 13.515616.03YesNo098
93S:S:F668 S:S:I841 13.45943.77YesNo099
94S:S:F684 S:S:I841 13.62416.33YesNo089
95S:S:F684 S:S:F688 25.84857.5YesYes088
96S:S:F688 S:S:L848 30.87622.44YesYes087
97S:S:L848 S:S:S810 31.68834.5YesNo079
98S:S:C851 S:S:S810 33.10813.44NoNo089
99S:S:C851 S:S:F806 40.4732.79NoNo085
100S:S:F806 S:S:F809 42.67942.14NoNo059
101R:R:F809 S:S:F809 43.29878.57NoNo099
102R:R:F809 R:R:K805 44.07163.72NoNo099
103R:R:F806 R:R:K805 44.22612.48NoNo059
104R:R:F806 R:R:N855 44.38048.46NoNo059
105R:R:K856 R:R:N855 44.53485.6YesNo099
106R:R:K856 R:R:T646 44.77844.5YesNo1599
107R:R:S651 R:R:T646 45.09784.8NoNo099
108R:R:F634 R:R:S651 45.253.96NoNo099
109R:R:F634 R:R:F853 45.40266.43NoYes099
110R:R:F853 R:R:I852 51.091211.3YesNo099
111R:R:I695 R:R:I852 52.30462.94YesNo079
112R:R:C787 R:R:I695 60.46793.27NoYes087
113R:R:C787 R:R:I692 63.1423.27NoNo087
114R:R:F688 R:R:I692 64.15313.77YesNo087
115R:R:F684 R:R:F688 64.71025.36YesYes088
116R:R:F684 R:R:I841 83.41418.84YesNo089
117R:R:I841 R:R:S665 83.55383.1NoNo098
118R:R:L842 R:R:S665 83.8333NoNo098
119R:R:L842 R:R:V838 84.11212.98NoNo097
120R:R:I669 R:R:V838 84.15343.07YesNo6387
121R:R:I669 R:R:L606 85.14194.28YesNo089
122R:R:K831 R:R:L606 85.41984.23YesNo099
123R:R:E604 R:R:K831 86.90626.75NoYes069
124R:R:E604 R:R:I760 86.91384.1NoYes3465
125R:R:E759 R:R:I760 88.8554.1NoYes045
126R:R:D758 R:R:E759 88.99275.2NoNo044
127R:R:D758 R:R:W590 89.130512.28NoNo046
128R:R:G571 R:R:W590 89.26818.44YesNo076
129R:R:E572 R:R:G571 91.32711.64NoYes077
130R:R:E572 R:R:P569 91.46411NoNo075
131R:R:C568 R:R:P569 91.60081.88NoNo095
132R:R:C568 R:R:C582 92.01097.28NoNo099
133R:R:C582 R:R:R551 92.14754.18NoYes097
134R:R:R551 S:S:R551 92.693419.19YesNo077
135S:S:G553 S:S:R551 92.96611.5NoNo067
136S:S:G553 S:S:I554 93.10231.76NoNo063
137S:S:F684 X:X:?3 10.443215.1YesYes1080
138R:R:F684 W:W:?3 20.13912.27YesYes080
139R:R:L334 R:R:Y408 12.610.55YesYes263
140R:R:L334 R:R:R69 12.66323.64YesYes268
141R:R:R66 R:R:R69 23.59354.26YesYes258
142R:R:R66 W:W:?1 27.76695.24YesYes250
143R:R:F330 R:R:R69 12.96623.21YesYes288
144R:R:I327 R:R:Y421 15.75426.04YesYes068
145R:R:I327 R:R:L414 10.23152.85YesYes066
146R:R:Y421 R:R:Y425 14.74518.86YesYes3888
147R:R:H429 R:R:Y425 12.24523.27NoYes068
148R:R:A230 R:R:I235 27.63563.25NoNo067
149R:R:A230 R:R:F226 27.61832.77NoNo066
150R:R:F226 R:R:T211 27.57312.59NoYes065
151R:R:I237 R:R:T211 27.51724.56NoYes065
152R:R:I237 R:R:R227 27.51352.51NoNo064
153S:S:T111 S:S:V153 17.63497.93NoYes776
154S:S:T145 X:X:?1 11.45513.18YesYes150
155R:R:L174 R:R:R185 11.17954.86YesYes579
156R:R:F180 R:R:L174 10.7937.31YesYes557
157R:R:N178 S:S:Y246 10.89853.49NoNo033
158R:R:I235 R:R:V209 25.89713.07NoYes878
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:N64 S:S:R66 3.62 0 No Yes 4 5 2 1
S:S:R66 S:S:R69 5.33 1 Yes Yes 5 8 1 2
S:S:R66 S:S:W70 10 1 Yes Yes 5 5 1 2
S:S:R66 X:X:?1 5.24 1 Yes Yes 5 0 1 2
S:S:R66 X:X:?2 22.36 1 Yes Yes 5 0 1 2
M:M:?7 S:S:R66 4.47 0 No Yes 0 5 0 1
S:S:R69 X:X:?2 13.98 1 Yes Yes 8 0 2 2
S:S:W70 X:X:?2 7.86 1 Yes Yes 5 0 2 2
S:S:G273 S:S:S302 3.71 6 No Yes 4 5 2 1
S:S:G273 S:S:I305 3.53 6 No Yes 4 4 2 2
S:S:L304 S:S:S302 3 6 Yes Yes 2 5 2 1
S:S:I305 S:S:S302 3.1 6 Yes Yes 4 5 2 1
M:M:?7 S:S:S302 5.52 0 No Yes 0 5 0 1
M:M:?7 S:S:S303 2.76 0 No No 0 3 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:P39 S:S:W70 4.05 1 Yes Yes 6 5 2 2
S:S:P39 S:S:T145 5.25 1 Yes Yes 6 5 2 1
I:I:?6 S:S:P39 9.06 1 Yes Yes 0 6 2 2
S:S:N64 S:S:R66 3.62 0 No Yes 4 5 2 1
S:S:R66 S:S:R69 5.33 1 Yes Yes 5 8 1 2
S:S:R66 S:S:W70 10 1 Yes Yes 5 5 1 2
S:S:R66 X:X:?1 5.24 1 Yes Yes 5 0 1 0
S:S:R66 X:X:?2 22.36 1 Yes Yes 5 0 1 2
M:M:?7 S:S:R66 4.47 0 No Yes 0 5 2 1
S:S:R69 X:X:?2 13.98 1 Yes Yes 8 0 2 2
S:S:T145 S:S:W70 3.64 1 Yes Yes 5 5 1 2
S:S:W70 S:S:Y167 4.82 1 Yes Yes 5 8 2 2
S:S:I416 S:S:W70 16.44 1 Yes Yes 4 5 1 2
S:S:W70 X:X:?2 7.86 1 Yes Yes 5 0 2 2
S:S:T145 S:S:Y167 4.99 1 Yes Yes 5 8 1 2
S:S:A168 S:S:T145 3.36 0 No Yes 5 5 2 1
S:S:T145 X:X:?1 3.18 1 Yes Yes 5 0 1 0
I:I:?6 S:S:T145 5.42 1 Yes Yes 0 5 2 1
S:S:S147 S:S:S169 3.26 0 No Yes 8 8 1 2
S:S:S147 S:S:S171 3.26 0 No No 8 7 1 2
S:S:S147 X:X:?1 5.4 0 No Yes 8 0 1 0
S:S:D190 S:S:S170 8.83 1 Yes No 8 7 2 1
S:S:S170 X:X:?1 7.56 0 No Yes 7 0 1 0
S:S:D190 S:S:Y218 5.75 1 Yes Yes 8 7 2 1
S:S:D190 S:S:F270 7.17 1 Yes Yes 8 7 2 2
S:S:D216 S:S:Y218 3.45 0 No Yes 6 7 2 1
S:S:G219 S:S:Y218 4.35 1 No Yes 7 7 2 1
S:S:F270 S:S:Y218 11.35 1 Yes Yes 7 7 2 1
S:S:S296 S:S:Y218 3.82 1 No Yes 8 7 2 1
S:S:A298 S:S:Y218 4 1 No Yes 6 7 1 1
S:S:Y218 X:X:?1 16.86 1 Yes Yes 7 0 1 0
S:S:F270 S:S:G219 3.01 1 Yes No 7 7 2 2
S:S:F270 S:S:S296 7.93 1 Yes No 7 8 2 2
S:S:E297 S:S:L322 10.6 1 No No 8 4 1 2
S:S:E297 S:S:I416 4.1 1 No Yes 8 4 1 1
S:S:E297 X:X:?1 7.62 1 No Yes 8 0 1 0
S:S:A298 X:X:?1 7.93 1 No Yes 6 0 1 0
S:S:I416 S:S:N419 2.83 1 Yes No 4 7 1 2
S:S:I416 X:X:?1 3.08 1 Yes Yes 4 0 1 0
S:S:I416 X:X:?2 11.5 1 Yes Yes 4 0 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F684 S:S:S664 5.28 10 Yes No 8 6 1 2
S:S:F668 S:S:Q681 5.86 0 Yes Yes 9 9 2 1
S:S:E837 S:S:F668 16.32 0 No Yes 9 9 1 2
S:S:F668 S:S:I841 3.77 0 Yes No 9 9 2 2
S:S:Q681 S:S:W742 3.29 10 Yes Yes 9 9 1 2
S:S:L773 S:S:Q681 7.99 10 Yes Yes 8 9 1 1
S:S:Q681 X:X:?3 13.41 10 Yes Yes 9 0 1 0
S:S:F684 S:S:G685 3.01 10 Yes No 8 8 1 2
S:S:F684 S:S:F688 7.5 10 Yes Yes 8 8 1 2
S:S:F684 S:S:W818 4.01 10 Yes Yes 8 9 1 1
S:S:F684 S:S:I841 16.33 10 Yes No 8 9 1 2
S:S:F684 X:X:?3 15.1 10 Yes Yes 8 0 1 0
S:S:F688 S:S:F814 6.43 0 Yes Yes 8 9 2 2
S:S:Q735 S:S:V689 10.03 32 Yes No 9 7 2 2
S:S:T780 S:S:V689 4.76 0 No No 7 7 1 2
S:S:L776 S:S:Q735 6.65 0 No Yes 8 9 1 2
S:S:L773 S:S:W742 3.42 10 Yes Yes 8 9 1 2
S:S:E767 S:S:L773 3.98 10 No Yes 7 8 1 1
S:S:E767 X:X:?3 9.24 10 No Yes 7 0 1 0
S:S:L773 X:X:?3 8.58 10 Yes Yes 8 0 1 0
S:S:L776 X:X:?3 3.22 0 No Yes 8 0 1 0
S:S:I777 X:X:?3 12.17 0 No Yes 8 0 1 0
S:S:T780 X:X:?3 4.57 0 No Yes 7 0 1 0
S:S:F814 S:S:W818 13.03 0 Yes Yes 9 9 2 1
S:S:V817 S:S:W818 3.68 0 No Yes 9 9 2 1
S:S:F821 S:S:W818 10.02 10 Yes Yes 9 9 1 1
S:S:A840 S:S:W818 3.89 10 No Yes 9 9 2 1
S:S:W818 X:X:?3 15.89 10 Yes Yes 9 0 1 0
S:S:F821 S:S:Y825 8.25 10 Yes No 9 9 1 1
S:S:A840 S:S:F821 2.77 10 No Yes 9 9 2 1
S:S:F821 X:X:?3 3.77 10 Yes Yes 9 0 1 0
S:S:Y825 X:X:?3 15.44 10 No Yes 9 0 1 0
S:S:E837 X:X:?3 5.13 0 No Yes 9 0 1 0
S:S:V833 S:S:Y825 2.52 0 No No 6 9 2 1
S:S:L770 X:X:?3 2.14 0 No Yes 3 0 1 0
S:S:G778 S:S:I777 1.76 0 No No 5 8 2 1
S:S:G774 S:S:L773 1.71 0 No Yes 4 8 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:G273 R:R:S302 3.71 33 No Yes 4 5 2 1
R:R:G273 R:R:I305 3.53 33 No Yes 4 4 2 2
R:R:L304 R:R:S302 3 0 Yes Yes 2 5 2 1
R:R:I305 R:R:S302 3.1 33 Yes Yes 4 5 2 1
L:L:?3 R:R:S302 5.52 0 No Yes 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:N64 R:R:P39 3.26 0 No Yes 4 6 2 2
R:R:P39 R:R:W70 4.05 2 Yes Yes 6 5 2 2
R:R:P39 R:R:T145 6.99 2 Yes Yes 6 5 2 1
I:I:?2 R:R:P39 9.06 2 Yes Yes 0 6 2 2
R:R:N64 R:R:R66 3.62 0 No Yes 4 5 2 1
R:R:R66 R:R:R69 4.26 2 Yes Yes 5 8 1 2
R:R:R66 R:R:W70 13 2 Yes Yes 5 5 1 2
R:R:R66 W:W:?1 5.24 2 Yes Yes 5 0 1 0
R:R:R66 W:W:?2 20.97 2 Yes Yes 5 0 1 2
R:R:R69 W:W:?2 11.18 2 Yes Yes 8 0 2 2
R:R:T145 R:R:W70 3.64 2 Yes Yes 5 5 1 2
R:R:W70 R:R:Y167 4.82 2 Yes Yes 5 8 2 2
R:R:W70 W:W:?2 7.86 2 Yes Yes 5 0 2 2
R:R:T145 R:R:Y167 4.99 2 Yes Yes 5 8 1 2
R:R:A168 R:R:T145 3.36 0 No Yes 5 5 2 1
R:R:T145 W:W:?1 5.3 2 Yes Yes 5 0 1 0
I:I:?2 R:R:T145 5.42 2 Yes Yes 0 5 2 1
R:R:S147 R:R:S171 3.26 0 No No 8 7 1 2
R:R:S147 W:W:?1 5.4 0 No Yes 8 0 1 0
R:R:I187 R:R:S170 4.64 0 Yes No 6 7 2 1
R:R:D190 R:R:S170 8.83 0 No No 8 7 2 1
R:R:S170 W:W:?1 7.56 0 No Yes 7 0 1 0
R:R:I187 R:R:L322 2.85 0 Yes No 6 4 2 2
R:R:D190 R:R:Q193 5.22 0 No Yes 8 9 2 2
R:R:D190 R:R:Y218 5.75 0 No Yes 8 7 2 1
R:R:Q193 R:R:S296 2.89 23 Yes No 9 8 2 2
R:R:E297 R:R:Q193 3.82 0 No Yes 8 9 1 2
R:R:D216 R:R:Y218 3.45 0 No Yes 6 7 2 1
R:R:S296 R:R:Y218 5.09 0 No Yes 8 7 2 1
R:R:A298 R:R:Y218 4 2 No Yes 6 7 1 1
R:R:Y218 W:W:?1 18.55 2 Yes Yes 7 0 1 0
R:R:E297 R:R:L322 10.6 0 No No 8 4 1 2
R:R:E297 W:W:?1 5.72 0 No Yes 8 0 1 0
R:R:A298 W:W:?1 7.93 2 No Yes 6 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F684 R:R:S664 3.96 0 Yes No 8 6 1 2
R:R:E837 R:R:F668 8.16 27 No No 9 9 1 2
R:R:P682 R:R:Q681 3.16 0 No Yes 5 9 2 1
R:R:Q681 R:R:W742 5.48 27 Yes Yes 9 9 1 2
R:R:E767 R:R:Q681 5.1 0 No Yes 7 9 2 1
R:R:L773 R:R:Q681 3.99 27 Yes Yes 8 9 1 1
R:R:Q681 W:W:?3 10.31 27 Yes Yes 9 0 1 0
R:R:F684 R:R:F688 5.36 0 Yes Yes 8 8 1 2
R:R:F684 R:R:I841 18.84 0 Yes No 8 9 1 2
R:R:F684 W:W:?3 12.27 0 Yes Yes 8 0 1 0
R:R:F688 R:R:F814 6.43 0 Yes No 8 9 2 2
R:R:L776 R:R:Q735 7.99 0 Yes No 8 9 1 2
R:R:I738 R:R:L776 2.85 0 No Yes 8 8 2 1
R:R:L776 R:R:W742 3.42 0 Yes Yes 8 9 1 2
R:R:I777 R:R:L773 4.28 27 No Yes 8 8 1 1
R:R:L773 W:W:?3 3.22 27 Yes Yes 8 0 1 0
R:R:L776 W:W:?3 3.22 0 Yes Yes 8 0 1 0
R:R:I777 W:W:?3 16.59 27 No Yes 8 0 1 0
R:R:T780 W:W:?3 6.85 0 No Yes 7 0 1 0
R:R:F814 R:R:W818 11.02 0 No No 9 9 2 1
R:R:A840 R:R:W818 7.78 0 No No 9 9 2 1
R:R:W818 W:W:?3 22.06 0 No Yes 9 0 1 0
R:R:E837 R:R:Y825 5.61 27 No No 9 9 1 1
R:R:Y825 W:W:?3 9.99 27 No Yes 9 0 1 0
R:R:E837 W:W:?3 12.32 27 No Yes 9 0 1 0
R:R:G685 W:W:?3 2.65 0 No Yes 8 0 1 0
R:R:V833 R:R:Y825 2.52 0 No No 6 9 2 1
R:R:G778 R:R:I777 1.76 0 No No 5 8 2 1
R:R:G774 R:R:L773 1.71 0 No Yes 4 8 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9AYF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.72
Number of Linked Nodes 1564
Number of Links 1900
Number of Hubs 295
Number of Links mediated by Hubs 1103
Number of Communities 67
Number of Nodes involved in Communities 472
Number of Links involved in Communities 650
Path Summary
Number Of Nodes in MetaPath 159
Number Of Links MetaPath 158
Number of Shortest Paths 6307301
Length Of Smallest Path 3
Average Path Length 50.5814
Length of Longest Path 110
Minimum Path Strength 1.315
Average Path Strength 6.14738
Maximum Path Strength 35.345
Minimum Path Correlation 0.7
Average Path Correlation 0.998662
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.21951
Average % Of Corr. Nodes 62.1023
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.1907
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • amino acid binding   • identical protein binding   • protein binding   • cation binding   • ion binding   • calcium ion binding   • metal ion binding   • small molecule binding   • phosphoric ester hydrolase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • phospholipase C activity   • hydrolase activity   • phosphatidylinositol-4,5-bisphosphate phospholipase C activity   • catalytic activity   • phospholipase activity   • lipase activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • transmembrane transporter binding   • cell adhesion molecule binding   • protein-containing complex binding   • integrin binding   • signaling receptor binding   • protein homodimerization activity   • protein dimerization activity   • kinase binding   • enzyme binding   • protein kinase binding   • biological regulation   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • regulation of biological process   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization
Gene OntologyBiological Process• biological regulation   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • regulation of biological process   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • developmental process   • multicellular organismal process   • epithelium development   • tube development   • branching morphogenesis of an epithelial tube   • morphogenesis of an epithelium   • tissue development   • tissue morphogenesis   • anatomical structure morphogenesis   • multicellular organism development   • tube morphogenesis   • morphogenesis of a branching structure   • anatomical structure development   • epithelial tube morphogenesis   • morphogenesis of a branching epithelium   • regulation of tube diameter   • system process   • regulation of tube size   • regulation of system process   • positive regulation of biological process   • positive regulation of vasoconstriction   • circulatory system process   • regulation of blood circulation   • vascular process in circulatory system   • regulation of vasoconstriction   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • blood vessel diameter maintenance   • vasoconstriction   • blood circulation   • regulation of anatomical structure size   • monoatomic ion transmembrane transport   • chloride transport   • transmembrane transport   • chloride transmembrane transport   • monoatomic anion transport   • monoatomic anion transmembrane transport   • cellular process   • inorganic anion transport   • regulation of biosynthetic process   • regulation of cellular process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • response to stimulus   • response to stress   • response to ischemia   • response to decreased oxygen levels   • cellular response to stimulus   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to chemical stimulus   • cellular response to stress   • response to hypoxia   • response to chemical   • response to oxygen levels   • response to abiotic stimulus   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • organic acid transport   • bile acid secretion   • organic anion transport   • monocarboxylic acid transport   • carboxylic acid transport   • secretion   • acid secretion   • response to peptide   • cellular response to peptide   • behavior   • chemosensory behavior   • signaling   • intracellular signal transduction   • cell communication   • JNK cascade   • intracellular signaling cassette   • MAPK cascade   • signal transduction   • cellular response to low-density lipoprotein particle stimulus   • response to endogenous stimulus   • response to lipoprotein particle   • response to nitrogen compound   • cellular response to lipoprotein particle stimulus   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • regulation of calcium ion import   • positive regulation of calcium ion transport   • positive regulation of calcium ion import   • positive regulation of transport   • positive regulation of monoatomic ion transport   • calcium ion import   • ossification   • connective tissue development   • adipose tissue development   • fat pad development   • animal organ development   • response to fibroblast growth factor   • response to growth factor   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • response to oxygen-containing compound   • cellular response to glucose stimulus   • intracellular glucose homeostasis   • cellular response to oxygen-containing compound   • response to hexose   • cellular response to carbohydrate stimulus   • response to monosaccharide   • response to carbohydrate   • response to glucose   • glucose homeostasis   • carbohydrate homeostasis   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • response to nutrient levels   • response to lipid   • response to nutrient   • response to vitamin   • cellular response to vitamin D   • cellular response to nutrient levels   • response to vitamin D   • cellular response to vitamin   • cellular response to lipid   • cellular response to nutrient   • cell population proliferation   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • vasodilation   • positive chemotaxis   • chemotaxis   • positive regulation of locomotion   • regulation of response to external stimulus   • positive regulation of positive chemotaxis   • response to external stimulus   • regulation of chemotaxis   • positive regulation of chemotaxis   • regulation of positive chemotaxis   • positive regulation of response to external stimulus   • taxis   • regulation of locomotion   • locomotion   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular response to endogenous stimulus   • response to hepatocyte growth factor   • cellular response to growth factor stimulus   • cellular response to hepatocyte growth factor stimulus   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • positive regulation of insulin secretion   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • regulation of protein secretion   • regulation of secretion   • positive regulation of protein localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • positive regulation of secretion   • amide transport   • signal release   • positive regulation of peptide secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • detection of stimulus   • response to metal ion   • detection of chemical stimulus   • detection of calcium ion   • response to calcium ion   • cell periphery   • presynapse   • cellular anatomical structure   • synapse   • cell junction   • membrane   • plasma membrane   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse
Gene OntologyCellular Component• cell periphery   • presynapse   • cellular anatomical structure   • synapse   • cell junction   • membrane   • plasma membrane   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse   • somatodendritic compartment   • cell body   • neuronal cell body   • apical part of cell   • apical plasma membrane   • cell surface   • axon   • neuron projection   • axon terminus   • plasma membrane bounded cell projection   • cell projection   • distal axon   • neuron projection terminus   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • ciliary basal body   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Type 1 solute binding protein-like   • TNF receptor-like   • Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Type 1 solute binding protein-like   • TNF receptor-like   • Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8 H:H:?9 H:H:?10 H:H:?11 H:H:?12 H:H:?13 H:H:?14
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylglucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodeTCR
PDB ResiduesX:X:?1 W:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeTCR
NameCYCLOMETHYLTRYPTOPHAN
Synonyms
Identifier
FormulaC12 H12 N2 O2
Molecular Weight216.236
SMILES
PubChem449440
Formal Charge0
Total Atoms28
Total Chiral Atoms1
Total Bonds30
Total Aromatic Bonds10

CodePO4
PDB ResiduesX:X:?2 W:W:?2
Environment DetailsOpen EMBL-EBI Page
CodePO4
NamePhosphate ion
Synonyms
  • Orthophosphate
  • Phosphate ion
  • Phosphate
Identifier
FormulaO4 P
Molecular Weight94.971
SMILES
PubChem1061
Formal Charge-3
Total Atoms5
Total Chiral Atoms0
Total Bonds4
Total Aromatic Bonds0

CodeCA
PDB ResiduesI:I:?5 I:I:?6 M:M:?7 I:I:?8 I:I:?1 I:I:?2 L:L:?3 I:I:?4
Environment DetailsOpen EMBL-EBI Page
CodeCA
NameCALCIUM ION
Synonyms
Identifier
FormulaCa
Molecular Weight40.078
SMILES
PubChem
Formal Charge2
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

Code9IG
PDB ResiduesX:X:?3 W:W:?3
Environment DetailsOpen EMBL-EBI Page
Code9IG
Name3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine
Synonyms
Identifier
FormulaC18 H22 Cl N O
Molecular Weight303.826
SMILES
PubChem158797
Formal Charge0
Total Atoms43
Total Chiral Atoms1
Total Bonds44
Total Aromatic Bonds12

PDBsumOpen PDBsum Page
ChainS
ProteinReceptor
UniProtP41180
Sequence
>9AYF_nogp_Chain_S
PDQRAQKKG DIILGGLFP IHFGVAAKD QDLKSRPES VECIRYNFR 
GFRWLQAMI FAIEEINSS PALLPNLTL GYRIFDTCN TVSKALEAT 
LSFVAQNKI DSLNIPSTI AVVGATGSG VSTAVANLL GLFYIPQVS 
YASSSRLLS NKNQFKSFL RTIPNDEHQ ATAMADIIE YFRWNWVGT 
IAADDDYGR PGIEKFREE AEERDICID FSELISQYS DEEEIQHVV 
EVIQNSTAK VIVVFSSGP DLEPLIKEI VRRNITGKI WLASEAWAS 
SSLIAMPQY FHVVGGTIG FALKAGQIP GFREFLKKV HPRKSVHNG 
FAKEFWEET FNCHLRPLC TGDENISSV ETPYIDYTH LRISYNVYL 
AVYSIAHAL QDIYTCLPG RGLFTNGSC ADIKKVEAW QVLKHLRHL 
NFTNNMGEQ VTFDECGDL VGNYSIINW HLSPEDGSI VFKEVGYYN 
VYAKKGERL FINEEKILW SGFSREVPF SNCSRDCLA GTRKGIIEG 
EPTCCFECV ECPDGEYSD ETDASACNK CPDDFWSNE NHTSCIAKE 
IEFLSWTEP FGIALTLFA VLGIFLTAF VLGVFIKFR NTPIVKATN 
RELSYLLLF SLLCCFSSS LFFIGEPQD WTCRLRQPA FGISFVLCI 
SCILVKNLQ FLLVFLCTF MQIVICVIW LYTAPPSSY RNQELEDEI 
IFITCHEGS LMALGFLIG YTCLLAAIC FFFAFKSRK LPENFNEAK 
FITFSMLIF FIVWISFIP AYASTYGKF VSAVEVIAI LAASFGLLA 
CIFFNKIYI ILFKPS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP41180
Sequence
>9AYF_nogp_Chain_R
GPDQRAQKK GDIILGGLF PIHFGVAAK DQDLKSRPE SVECIRYNF 
RGFRWLQAM IFAIEEINS SPALLPNLT LGYRIFDTC NTVSKALEA 
TLSFVAQNK IDSLNIPST IAVVGATGS GVSTAVANL LGLFYIPQV 
SYASSSRLL SNKNQFKSF LRTIPNDEH QATAMADII EYFRWNWVG 
TIAADDDYG RPGIEKFRE EAEERDICI DFSELISQY SDEEEIQHV 
VEVIQNSTA KVIVVFSSG PDLEPLIKE IVRRNITGK IWLASEAWA 
SSSLIAMPQ YFHVVGGTI GFALKAGQI PGFREFLKK VHPRKSVHN 
GFAKEFWEE TFNCHLRPL CTGDENISS VETPYIDYT HLRISYNVY 
LAVYSIAHA LQDIYTCLP GRGLFTNGS CADIKKVEA WQVLKHLRH 
LNFTNNMGE QVTFDECGD LVGNYSIIN WHLSPEDGS IVFKEVGYY 
NVYAKKGER LFINEEKIL WSGFSREVP FSNCSRDCL AGTRKGIIE 
GEPTCCFEC VECPDGEYS DETDASACN KCPDDFWSN ENHTSCIAK 
EIEFLSWTE PFGIALTLF AVLGIFLTA FVLGVFIKF RNTPIVKAT 
NRELSYLLL FSLLCCFSS SLFFIGEPQ DWTCRLRQP AFGISFVLC 
ISCILVKTN RVLLVFEAK IPTSFHRKW WGLNLQFLL VFLCTFMQI 
VICVIWLYT APPSSYRNQ ELEDEIIFI TCHEGSLMA LGFLIGYTC 
LLAAICFFF AFKSRKLPE NFNEAKFIT FSMLIFFIV WISFIPAYA 
STYGKFVSA VEVIAILAA SFGLLACIF FNKIYIILF KPSRNTIEE 
VRCSTA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WPGCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca-2.72023-11-22doi.org/10.1038/s41422-023-00892-2
8WPUCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(NtGi2L-Gs-CtGq)/β1/γ23.12023-11-22doi.org/10.1038/s41422-023-00892-2
8WPU (No Gprot) CIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca3.12023-11-22doi.org/10.1038/s41422-023-00892-2
7DTUCIonCalcium SensingCaSHomo sapiens-Tryptophan-4.42021-03-10doi.org/10.1038/s41422-021-00474-0
7M3JCIonCalcium SensingCaSHomo sapiens-NPS-2143; PO4-4.12021-06-30doi.org/10.1038/s41586-021-03691-0
7SINCIonCalcium SensingCaSHomo sapiens-NPS-2143-5.92022-01-19doi.org/10.1073/pnas.2115849118
9C1PCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan; '6218; PO4-2.82024-10-02doi.org/10.1126/science.ado1868
7DTVCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan-3.52021-03-10doi.org/10.1038/s41422-021-00474-0
7M3ECIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; NPS-2143-3.22021-06-30doi.org/10.1038/s41586-021-03691-0
7DD5CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; NPS-2143-3.22021-06-16doi.org/10.1126/sciadv.abg1483
7M3GCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4-2.52021-06-30doi.org/10.1038/s41586-021-03691-0
7DD7CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; Evocalcet-3.22021-06-16doi.org/10.1126/sciadv.abg1483
8SZFCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-2.82024-02-07doi.org/10.1038/s41586-024-07055-2
8SZGCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Sperminechim(NtGi1-Gq)/β1/γ23.62024-02-07doi.org/10.1038/s41586-024-07055-2
8SZG (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine3.62024-02-07doi.org/10.1038/s41586-024-07055-2
8SZHCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; SpermineGi1/β1/γ23.12024-02-07doi.org/10.1038/s41586-024-07055-2
8SZH (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine3.12024-02-07doi.org/10.1038/s41586-024-07055-2
7M3FCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4-2.82021-06-30doi.org/10.1038/s41586-021-03691-0
8SZICIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4Gi3/β1/γ23.52024-02-07doi.org/10.1038/s41586-024-07055-2
8SZI (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO43.52024-02-07doi.org/10.1038/s41586-024-07055-2
9C2FCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Tryptophan; '54149; PO4-2.82024-10-02doi.org/10.1126/science.ado1868
7DD6CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan-3.22021-06-16doi.org/10.1126/sciadv.abg1483
7SIMCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-2.72022-01-19doi.org/10.1073/pnas.2115849118
7E6TCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-32021-09-22doi.org/10.7554/eLife.68578
9ASBCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.42024-04-17doi.org/10.1038/s41586-024-07331-1
9ASB (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.42024-04-17doi.org/10.1038/s41586-024-07331-1
9AVGCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs)/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AVG (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AVLCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4Gi3/β2/γ23.82024-04-17doi.org/10.1038/s41586-024-07331-1
9AVL (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.82024-04-17doi.org/10.1038/s41586-024-07331-1
9AXFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.52024-04-17doi.org/10.1038/s41586-024-07331-1
9AXF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.52024-04-17doi.org/10.1038/s41586-024-07331-1
9AYFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4Gi1/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AYF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-17doi.org/10.1038/s41586-024-07331-1
7SILCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-2.72022-01-19doi.org/10.1073/pnas.2115849118
7DTTCIonCalcium SensingCaSHomo sapiensCaCa-3.82021-03-10doi.org/10.1038/s41422-021-00474-0
7DTWCIonCalcium SensingCaSHomo sapiens---4.52021-03-10doi.org/10.1038/s41422-021-00474-0
7E6UCIonCalcium SensingCaSHomo sapiens---62021-09-22doi.org/10.7554/eLife.68578




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