Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1H:H:?3 18.17336130
2H:H:?5 18.86836240
3H:H:?7 18.2983670
4I:I:?3 6.572510
5R:R:F38 9.4325417
6R:R:P39 7.0825416
7R:R:I40 7.882515
8R:R:H41 8.102517
9R:R:F42 10.8765263
10R:R:Y63 7.44714715
11R:R:F65 8.102512
12R:R:R66 11.5725415
13R:R:F68 9.96667617
14R:R:R69 7.344518
15R:R:W70 9.29625815
16R:R:L71 5.69167614
17R:R:Q72 6.82517
18R:R:M74 6408
19R:R:I75 5.75414
20R:R:I81 6.09519
21R:R:L87 6.7625406
22R:R:L88 5.1675419
23R:R:Y95 8.03618
24R:R:R96 5.7485124
25R:R:I97 5.74508
26R:R:F98 7.653336124
27R:R:F114 6.855125
28R:R:K119 8.6475403
29R:R:T145 6.58333615
30R:R:S147 5.02418
31R:R:T151 5.415495
32R:R:Y167 9.025418
33R:R:S170 6.6417
34R:R:R172 7.34284
35R:R:L173 6.3745285
36R:R:L174 9.3875497
37R:R:S175 5.9325498
38R:R:F180 8.564595
39R:R:F183 8.754598
40R:R:R185 8.74599
41R:R:N189 5.5225498
42R:R:D190 7.2925418
43R:R:Q193 7.27519
44R:R:M197 4.6875417
45R:R:F204 7.92333617
46R:R:W206 7.90333619
47R:R:W208 9.06833679
48R:R:Y218 7.84875817
49R:R:R227 5.7725404
50R:R:E229 8.1654295
51R:R:R233 8.6785294
52R:R:I237 7.0325416
53R:R:F239 6.1425406
54R:R:I252 3.7075404
55R:R:I267 5.505437
56R:R:F270 6.126517
57R:R:P274 4.87754263
58R:R:D275 4.93254305
59R:R:L276 6.94535
60R:R:L279 4.685405
61R:R:I283 6.32434
62R:R:W293 5.46538
63R:R:W299 8.458537
64R:R:Y310 7.8533
65R:R:F311 10.09403
66R:R:V313 4.7125433
67R:R:F320 6.00667616
68R:R:I327 6.1525416
69R:R:F330 7.355618
70R:R:R331 8.65754334
71R:R:F333 7.088517
72R:R:H338 5.6125404
73R:R:N345 6.152518
74R:R:E350 6.526515
75R:R:F351 10.8083616
76R:R:W352 15.01418
77R:R:T355 7.35414
78R:R:Y408 9.712513
79R:R:I409 3.9685335
80R:R:L414 6.7975416
81R:R:S417 4.865616
82R:R:Y418 9.558517
83R:R:Y421 10.9825418
84R:R:Q432 5.362517
85R:R:Y435 5.8325413
86R:R:F444 5.3725453
87R:R:T445 2.6375401
88R:R:W458 11.932554
89R:R:Q459 9.856557
90R:R:L461 5.93457
91R:R:K462 7.59554
92R:R:H463 8.545405
93R:R:N471 4.3275416
94R:R:F479 6.7125408
95R:R:D484 8.82498
96R:R:N493 6.9275419
97R:R:W494 8.54667637
98R:R:S497 3.8475403
99R:R:N512 8.44244
100R:R:Y514 8.9745244
101R:R:I528 7.62417
102R:R:W530 8.6875818
103R:R:K552 8.43754358
104R:R:P559 5.682576
105R:R:F563 11.03254357
106R:R:Y573 9.40254196
107R:R:C582 5.2954369
108R:R:C585 4.24199
109R:R:T596 2.7025405
110R:R:C598 6.1754199
111R:R:F605 6.8725407
112R:R:L606 3.512509
113R:R:E610 4.82507
114R:R:T627 4.055407
115R:R:V630 4.69754397
116R:R:F634 5.136509
117R:R:R648 8.585408
118R:R:L655 6.39254399
119R:R:R680 10.2675408
120R:R:Q681 7.876509
121R:R:F684 10.964588
122R:R:F688 6.555608
123R:R:V689 5.405487
124R:R:Q724 11.67254418
125R:R:W742 6.358509
126R:R:P748 5.86409
127R:R:I760 5.334165
128R:R:I761 6.155157
129R:R:F762 6.95167
130R:R:C765 6.6875409
131R:R:F788 5.0275408
132R:R:F790 5.01254427
133R:R:F801 5.3075409
134R:R:F814 6.09167689
135R:R:F815 4.9525487
136R:R:W818 13.5575489
137R:R:F821 5.0865449
138R:R:P823 3.93409
139R:R:L849 3.35408
140R:R:F853 8.0125399
141S:S:L37 4.2925406
142S:S:F38 7.98527
143S:S:P39 7.16526
144S:S:I40 8.2825425
145S:S:H41 7.002527
146S:S:F42 13.214273
147S:S:L51 6.1575456
148S:S:P55 11456
149S:S:Y63 7.56286725
150S:S:F65 9.606522
151S:S:R66 10.605425
152S:S:F68 11.324527
153S:S:R69 7.678528
154S:S:W70 8.92222925
155S:S:L71 5.056524
156S:S:Q72 7.94427
157S:S:L93 4.865409
158S:S:Y95 10.53408
159S:S:I97 6.292508
160S:S:F98 8.692504
161S:S:F114 6.092505
162S:S:T145 7.452525
163S:S:T151 5.4054115
164S:S:F160 8.772507
165S:S:Y167 8.092528
166S:S:S170 7.17427
167S:S:R172 7.61754314
168S:S:L173 6.1865315
169S:S:L174 8.414117
170S:S:F180 8.91254115
171S:S:F183 8.1325118
172S:S:R185 6.9625119
173S:S:I187 4.064506
174S:S:D190 8.6475428
175S:S:Q193 7.998529
176S:S:M197 5.2175427
177S:S:F204 8.816527
178S:S:W206 9.308529
179S:S:W208 10.7485459
180S:S:T211 5.57254465
181S:S:Y218 8.46111927
182S:S:K225 8.2275403
183S:S:F226 5.9054466
184S:S:R233 6.353758214
185S:S:F239 6.1425406
186S:S:V266 8.7375427
187S:S:F270 9.292527
188S:S:D275 5.9125425
189S:S:L276 7.2475445
190S:S:E277 7.2975402
191S:S:I280 5.6725445
192S:S:I283 4.81404
193S:S:W293 6.82448
194S:S:E297 8.35428
195S:S:W299 8.25667647
196S:S:L304 8.80754272
197S:S:I305 5.8375444
198S:S:Y310 8.784543
199S:S:F311 9.745403
200S:S:F320 6.24167626
201S:S:I327 7.385426
202S:S:F330 8.786528
203S:S:F333 8.225407
204S:S:N345 4.59628
205S:S:F347 7.5375425
206S:S:E350 7.595425
207S:S:F351 10.505626
208S:S:W352 15.7425428
209S:S:T355 6.3775424
210S:S:F356 11.9775428
211S:S:E399 9.305428
212S:S:Y408 8.49667623
213S:S:L414 5.8325426
214S:S:I416 9.7325424
215S:S:S417 5.8375426
216S:S:Y418 8.358527
217S:S:Y421 9.096528
218S:S:Y425 12.305428
219S:S:F444 4.145103
220S:S:W458 11.6385104
221S:S:Q459 7.6725107
222S:S:L461 5.32254147
223S:S:K462 6.88754144
224S:S:H463 8.9275405
225S:S:M473 3.6075424
226S:S:F479 5.7408
227S:S:D484 7.844118
228S:S:N493 6.9025429
229S:S:W494 8.44714747
230S:S:S497 3.775503
231S:S:I503 5.1775444
232S:S:F505 6.775444
233S:S:Y511 8.905405
234S:S:K517 6.975211
235S:S:I523 5.3975426
236S:S:I528 8.5325427
237S:S:W530 9.67167628
238S:S:C562 5.58754459
239S:S:Y573 6.04754226
240S:S:C582 5.6409
241S:S:F589 4.72754225
242S:S:W590 6.9545526
243S:S:N592 5.04754537
244S:S:H595 5.8875405
245S:S:T596 3.84535
246S:S:C598 5.70754229
247S:S:W608 8.1425405
248S:S:E610 8.0145207
249S:S:T627 4.0554187
250S:S:F634 5.8825409
251S:S:L650 7.5965568
252S:S:L655 7.6954189
253S:S:S665 3.925408
254S:S:R678 3.54405
255S:S:R680 11.12254178
256S:S:Q681 8.645469
257S:S:F684 11.116568
258S:S:F688 7.656508
259S:S:I695 5.016507
260S:S:Q735 7.845469
261S:S:W742 6.702569
262S:S:I760 2.39405
263S:S:I763 5.16254177
264S:S:L773 6.365468
265S:S:F790 5.51254577
266S:S:E803 8.76409
267S:S:I807 4.7525409
268S:S:F809 5.0525409
269S:S:F814 9.485409
270S:S:W818 10.38669
271S:S:F821 10.3825469
272S:S:Y825 10.41469
273S:S:F832 10.0585205
274S:S:L849 4.214188
275S:S:F853 7.716189
276S:S:N867 8.8154559
277W:W:?1 7.365831210
278W:W:?2 10.5567610
279W:W:?3 13.76980
280X:X:?1 7.829091120
281X:X:?2 9.89833620
282X:X:?3 14.0911960
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:V284 R:R:Y310 96.49187.57NoYes333
2R:R:K281 R:R:Y310 99.95625.97NoYes023
3R:R:E277 R:R:K281 1006.75NoNo022
4R:R:E277 R:R:R62 49.90515.82NoNo024
5R:R:F42 R:R:R62 49.95385.34YesNo034
6L:L:?1 R:R:F42 94.79154.48NoYes003
7L:L:?1 W:W:?1 94.80243.66NoYes000
8R:R:Y218 W:W:?1 77.459323.6YesYes170
9R:R:F270 R:R:Y218 77.8635.16YesYes177
10R:R:F270 R:R:M197 77.94563.73YesYes177
11R:R:M197 R:R:V268 79.50534.56YesNo176
12R:R:F226 R:R:V268 79.503515.73NoNo166
13R:R:F226 R:R:I237 79.33773.77NoYes166
14R:R:I237 R:R:R227 79.357515.03YesYes064
15R:R:R227 S:S:R227 79.2854.26YesNo044
16S:S:I237 S:S:R227 79.26112.53NoNo064
17S:S:F226 S:S:I237 78.90733.77YesNo4666
18S:S:F226 S:S:V268 74.860511.8YesNo066
19S:S:L294 S:S:V268 74.83474.47NoNo076
20S:S:L294 S:S:M197 74.81024.24NoYes077
21S:S:F270 S:S:M197 29.77823.73YesYes277
22S:S:F270 S:S:Y218 27.951717.54YesYes277
23R:R:E277 R:R:L304 50.138711.93NoNo022
24R:R:F42 R:R:L304 49.858714.61YesNo2632
25R:R:V313 R:R:W293 94.84953.68YesYes338
26R:R:I267 R:R:W293 95.16418.22YesYes378
27R:R:F239 R:R:I267 95.63185.02YesYes067
28R:R:F239 R:R:S262 95.70545.28YesNo067
29R:R:D238 R:R:S262 95.65948.83NoNo087
30R:R:D238 R:R:W208 95.613316.75NoYes089
31R:R:P559 R:R:W208 95.36458.11YesYes769
32S:S:M197 S:S:Q193 44.77045.44YesYes279
33S:S:E297 S:S:Q193 44.06053.82YesYes289
34S:S:E297 X:X:?1 20.3449.53YesYes280
35S:S:T145 X:X:?1 10.68995.3YesYes250
36S:S:Y218 X:X:?1 20.599523.6YesYes270
37S:S:E297 S:S:I416 21.97785.47YesYes284
38S:S:I416 S:S:W70 11.841421.14YesYes245
39S:S:W70 X:X:?1 23.94756.55YesYes250
40R:R:T145 W:W:?1 12.55395.3YesYes150
41R:R:T145 R:R:Y167 11.6576.24YesYes158
42R:R:F38 R:R:Y167 11.468316.5YesYes178
43R:R:I81 R:R:Y425 10.79538.46YesNo198
44R:R:S417 R:R:W70 13.4954.94YesYes165
45R:R:I327 R:R:Y421 10.3019.67YesYes168
46S:S:S417 S:S:W70 20.63584.94YesYes265
47S:S:L414 S:S:S417 27.18934.5YesYes266
48S:S:I327 S:S:L414 26.02325.71YesYes266
49S:S:I327 S:S:Y421 25.812512.09YesYes268
50S:S:Y421 S:S:Y425 24.840116.88YesYes288
51S:S:I81 S:S:Y425 12.418514.51NoYes098
52S:S:I81 S:S:L87 12.02895.71NoNo096
53S:S:L87 S:S:Q432 23.76186.65NoNo067
54S:S:Q432 S:S:T436 13.64094.25NoNo074
55S:S:T436 S:S:Y435 13.25153.75NoNo043
56S:S:I452 S:S:Y435 12.08349.67NoNo033
57S:S:I434 S:S:I452 10.52574.42NoNo063
58S:S:H463 S:S:I434 10.136313.26YesNo056
59S:S:I416 X:X:?2 10.11288.21YesYes240
60S:S:H429 S:S:Y425 12.22964.36NoYes068
61S:S:H429 S:S:L87 12.121910.29NoNo066
62R:R:E558 R:R:P559 93.20237.86NoYes056
63R:R:E558 R:R:I555 93.1555.47NoNo055
64R:R:E564 R:R:I555 93.10764.1NoNo065
65R:R:E564 R:R:V566 93.06024.28NoNo064
66R:R:R551 R:R:V566 92.965317NoNo074
67R:R:C582 R:R:R551 88.77725.57YesNo097
68R:R:C568 R:R:C582 88.58767.28NoYes099
69R:R:C568 R:R:H595 88.53852.95NoNo095
70R:R:H595 R:R:S591 88.44075.58NoNo058
71R:R:G571 R:R:S591 87.80893.71NoNo078
72R:R:G571 R:R:W590 87.760211.26NoNo076
73R:R:D758 R:R:W590 87.711613.4NoNo046
74R:R:D758 R:R:E759 87.52245.2NoNo1644
75R:R:E759 R:R:I760 88.46025.47NoYes1645
76R:R:E604 R:R:I760 87.83128.2NoYes1665
77R:R:E604 R:R:K831 87.91185.4NoNo069
78R:R:E610 R:R:K831 86.85669.45YesNo079
79R:R:E610 R:R:S607 70.92932.87YesNo077
80R:R:F605 R:R:S607 70.81945.28YesNo077
81R:R:F605 R:R:I763 70.66517.54YesNo077
82R:R:E610 R:R:L606 16.18933.98YesYes079
83R:R:L616 R:R:V838 15.095410.43NoNo087
84R:R:L842 R:R:V838 14.94192.98NoNo097
85R:R:F619 R:R:L842 14.8511.22NoNo039
86R:R:F619 R:R:L622 14.72951.22NoNo033
87R:R:L622 R:R:L626 14.60865.54NoNo034
88R:R:I763 R:R:P672 70.32118.47NoNo079
89R:R:C765 R:R:P672 70.27223.77YesNo099
90R:R:C765 R:R:R680 36.331911.14YesYes098
91R:R:Q681 R:R:R680 33.83514.67YesYes098
92R:R:Q681 W:W:?3 63.955313.41YesYes090
93R:R:C765 R:R:E767 33.84294.56YesNo097
94R:R:E767 R:R:Q681 33.784314.02NoYes079
95R:R:L626 R:R:L849 14.48781.38NoYes048
96R:R:L849 R:R:V630 11.05272.98YesYes087
97R:R:I822 W:W:?3 53.86055.53NoYes070
98R:R:I822 R:R:P823 53.59463.39NoYes079
99R:R:P823 S:S:I839 52.92933.39YesNo097
100S:S:I839 S:S:L616 52.79632.85NoNo078
101S:S:L616 S:S:V838 52.663110.43NoNo087
102S:S:S665 S:S:V838 52.52994.85YesNo087
103S:S:I841 S:S:S665 40.6944.64NoYes098
104S:S:F684 S:S:I841 37.331715.07YesNo089
105S:S:F684 S:S:F688 29.329612.86YesYes088
106S:S:F688 S:S:L848 27.43697.31YesNo087
107S:S:I695 S:S:L848 27.30054.28YesNo077
108S:S:F38 S:S:P39 12.33934.33YesYes276
109S:S:F38 S:S:L71 14.68326.09YesYes274
110S:S:F38 S:S:Y167 12.044515.47YesYes278
111S:S:L842 S:S:S665 11.59744.5NoYes098
112S:S:F619 S:S:L842 11.45851.22NoNo039
113S:S:F619 S:S:L622 11.1841.22NoNo033
114S:S:L622 S:S:L626 11.04762.77NoNo034
115S:S:F854 S:S:L626 10.77544.87NoNo044
116S:S:F854 S:S:L849 10.50644.87NoYes048
117S:S:F853 S:S:V630 10.8685.24YesNo1897
118S:S:I857 S:S:V630 10.45439.22NoNo087
119S:S:F634 S:S:F853 11.70465.36YesYes099
120S:S:F634 S:S:I857 10.4515.02YesNo098
121S:S:I857 S:S:V633 20.06934.61NoNo085
122S:S:L861 S:S:V633 18.39748.94NoNo055
123S:S:F862 S:S:L861 17.56143.65NoNo055
124S:S:F862 S:S:Y858 16.72548.25NoNo058
125S:S:I859 S:S:Y858 13.38114.84NoNo098
126S:S:I859 S:S:R866 12.5455.01NoNo096
127S:S:E871 S:S:R866 11.708815.12NoNo056
128R:R:V284 R:R:V313 96.13016.41NoYes333
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:?1 S:S:F42 6.72 27 No Yes 0 3 0 1
M:M:?1 S:S:S302 5.52 27 No No 0 5 0 1
M:M:?1 S:S:L304 5.09 27 No Yes 0 2 0 1
S:S:F42 S:S:R62 8.55 27 Yes No 3 4 1 2
S:S:F42 S:S:N64 22.96 27 Yes No 3 4 1 2
S:S:F42 S:S:L304 14.61 27 Yes Yes 3 2 1 1
S:S:E277 S:S:R62 4.65 0 Yes No 2 4 2 2
S:S:G273 S:S:P274 4.06 0 No No 4 3 2 2
S:S:G273 S:S:S302 3.71 0 No No 4 5 2 1
S:S:L304 S:S:P274 4.93 27 Yes No 2 3 1 2
S:S:E277 S:S:L304 10.6 0 Yes Yes 2 2 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
I:I:?1 S:S:P39 9.06 2 No Yes 0 6 2 2
I:I:?1 S:S:T145 5.42 2 No Yes 0 5 2 1
S:S:P39 S:S:W70 5.4 2 Yes Yes 6 5 2 1
S:S:P39 S:S:T145 10.49 2 Yes Yes 6 5 2 1
S:S:R66 S:S:R69 4.26 2 Yes Yes 5 8 1 2
S:S:R66 S:S:W70 13 2 Yes Yes 5 5 1 1
S:S:R66 X:X:?1 6.99 2 Yes Yes 5 0 1 0
S:S:R66 X:X:?2 18.17 2 Yes Yes 5 0 1 2
S:S:G67 S:S:W70 5.63 0 No Yes 4 5 2 1
S:S:R69 S:S:S417 5.27 2 Yes Yes 8 6 2 2
S:S:R69 X:X:?2 8.39 2 Yes Yes 8 0 2 2
S:S:T145 S:S:W70 6.06 2 Yes Yes 5 5 1 1
S:S:W70 S:S:Y167 5.79 2 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 21.14 2 Yes Yes 4 5 1 1
S:S:S417 S:S:W70 4.94 2 Yes Yes 6 5 2 1
S:S:W70 X:X:?1 6.55 2 Yes Yes 5 0 1 0
S:S:W70 X:X:?2 11.79 2 Yes Yes 5 0 1 2
S:S:T145 S:S:Y167 9.99 2 Yes Yes 5 8 1 2
S:S:T145 X:X:?1 5.3 2 Yes Yes 5 0 1 0
S:S:S147 S:S:S171 4.89 2 No No 8 7 1 2
S:S:S147 S:S:Y218 3.82 2 No Yes 8 7 1 1
S:S:S147 X:X:?1 6.48 2 No Yes 8 0 1 0
S:S:I187 S:S:S170 4.64 0 Yes Yes 6 7 2 1
S:S:D190 S:S:S170 10.31 2 Yes Yes 8 7 2 1
S:S:S170 S:S:Y218 5.09 2 Yes Yes 7 7 1 1
S:S:S170 X:X:?1 8.64 2 Yes Yes 7 0 1 0
S:S:I187 S:S:L322 4.28 0 Yes No 6 4 2 2
S:S:D190 S:S:Q193 7.83 2 Yes Yes 8 9 2 2
S:S:D190 S:S:Y218 6.9 2 Yes Yes 8 7 2 1
S:S:D190 S:S:F270 9.55 2 Yes Yes 8 7 2 2
S:S:E297 S:S:Q193 3.82 2 Yes Yes 8 9 1 2
S:S:D216 S:S:Y218 4.6 2 No Yes 6 7 2 1
S:S:F270 S:S:Y218 17.54 2 Yes Yes 7 7 2 1
S:S:S296 S:S:Y218 6.36 2 No Yes 8 7 2 1
S:S:A298 S:S:Y218 5.34 2 No Yes 6 7 1 1
S:S:Y218 X:X:?1 23.6 2 Yes Yes 7 0 1 0
S:S:F270 S:S:S296 6.61 2 Yes No 7 8 2 2
S:S:E297 S:S:L322 14.58 2 Yes No 8 4 1 2
S:S:E297 S:S:I416 5.47 2 Yes Yes 8 4 1 1
S:S:E297 X:X:?1 9.53 2 Yes Yes 8 0 1 0
S:S:A298 X:X:?1 9.06 2 No Yes 6 0 1 0
S:S:I416 X:X:?1 4.11 2 Yes Yes 4 0 1 0
S:S:I416 X:X:?2 8.21 2 Yes Yes 4 0 1 2
S:S:S417 X:X:?2 8.64 2 Yes Yes 6 0 2 2
S:S:A168 X:X:?1 3.4 0 No Yes 5 0 1 0
S:S:G219 S:S:Y218 2.9 0 No Yes 7 7 2 1
S:S:G146 X:X:?1 2.46 0 No Yes 5 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:Q681 S:S:W742 4.38 6 Yes Yes 9 9 1 2
S:S:E767 S:S:Q681 11.47 6 No Yes 7 9 2 1
S:S:L773 S:S:Q681 5.32 6 Yes Yes 8 9 1 1
S:S:Q681 X:X:?3 13.41 6 Yes Yes 9 0 1 0
S:S:F684 S:S:F688 12.86 6 Yes Yes 8 8 1 2
S:S:F684 S:S:W818 8.02 6 Yes Yes 8 9 1 1
S:S:F684 S:S:I841 15.07 6 Yes No 8 9 1 2
S:S:F684 X:X:?3 16.99 6 Yes Yes 8 0 1 0
S:S:F688 S:S:F814 7.5 0 Yes Yes 8 9 2 2
S:S:Q735 S:S:V689 11.46 6 Yes No 9 7 2 2
S:S:T780 S:S:V689 4.76 6 No No 7 7 1 2
S:S:Q735 S:S:T780 5.67 6 Yes No 9 7 2 1
S:S:E767 S:S:W742 6.54 6 No Yes 7 9 2 2
S:S:E767 S:S:L773 6.63 6 No Yes 7 8 2 1
S:S:L773 X:X:?3 11.8 6 Yes Yes 8 0 1 0
S:S:I777 X:X:?3 16.59 0 No Yes 8 0 1 0
S:S:T780 X:X:?3 7.99 6 No Yes 7 0 1 0
S:S:F814 S:S:W818 12.03 0 Yes Yes 9 9 2 1
S:S:F821 S:S:W818 12.03 6 Yes Yes 9 9 2 1
S:S:A840 S:S:W818 7.78 6 No Yes 9 9 2 1
S:S:A844 S:S:W818 3.89 0 No Yes 9 9 2 1
S:S:W818 X:X:?3 18.53 6 Yes Yes 9 0 1 0
S:S:F821 S:S:Y825 11.35 6 Yes Yes 9 9 2 1
S:S:E837 S:S:F821 13.99 6 No Yes 9 9 1 2
S:S:A840 S:S:F821 4.16 6 No Yes 9 9 2 2
S:S:V833 S:S:Y825 3.79 0 No Yes 6 9 2 1
S:S:E837 S:S:Y825 5.61 6 No Yes 9 9 1 1
S:S:Y825 X:X:?3 20.89 6 Yes Yes 9 0 1 0
S:S:E837 X:X:?3 18.48 6 No Yes 9 0 1 0
S:S:F684 S:S:S664 2.64 6 Yes No 8 6 1 2
S:S:L770 X:X:?3 2.14 0 No Yes 3 0 1 0
S:S:G774 S:S:L773 1.71 0 No Yes 4 8 2 1
S:S:C781 S:S:I777 1.64 0 No No 7 8 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:F42 4.48 0 No Yes 0 3 0 1
L:L:?1 R:R:S302 5.52 0 No No 0 5 0 1
L:L:?1 W:W:?1 3.66 0 No Yes 0 0 0 1
R:R:F42 R:R:R62 5.34 26 Yes No 3 4 1 2
R:R:F42 R:R:N64 24.17 26 Yes No 3 4 1 2
R:R:F42 R:R:P274 5.78 26 Yes Yes 3 3 1 2
R:R:F42 R:R:L304 14.61 26 Yes No 3 2 1 2
R:R:R66 R:R:W70 13 1 Yes Yes 5 5 2 2
R:R:R66 W:W:?1 6.99 1 Yes Yes 5 0 2 1
R:R:T145 R:R:W70 6.06 1 Yes Yes 5 5 2 2
R:R:I416 R:R:W70 22.31 1 No Yes 4 5 2 2
R:R:W70 W:W:?1 6.55 1 Yes Yes 5 0 2 1
R:R:A168 R:R:T145 5.03 1 No Yes 5 5 2 2
R:R:T145 W:W:?1 5.3 1 Yes Yes 5 0 2 1
R:R:G146 W:W:?1 3.69 0 No Yes 5 0 2 1
R:R:S147 R:R:Y218 3.82 1 Yes Yes 8 7 2 2
R:R:S147 W:W:?1 6.48 1 Yes Yes 8 0 2 1
R:R:A168 W:W:?1 5.67 1 No Yes 5 0 2 1
R:R:S170 R:R:Y218 3.82 1 Yes Yes 7 7 2 2
R:R:S170 W:W:?1 7.56 1 Yes Yes 7 0 2 1
R:R:A298 R:R:Y218 5.34 1 No Yes 6 7 2 2
R:R:Y218 W:W:?1 23.6 1 Yes Yes 7 0 2 1
R:R:G273 R:R:P274 4.06 0 No Yes 4 3 2 2
R:R:G273 R:R:S302 3.71 0 No No 4 5 2 1
R:R:L304 R:R:P274 4.93 26 No Yes 2 3 2 2
R:R:E297 W:W:?1 5.72 0 No Yes 8 0 2 1
R:R:A298 W:W:?1 9.06 1 No Yes 6 0 2 1
R:R:I416 W:W:?1 4.11 1 No Yes 4 0 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
I:I:?3 R:R:P39 6.04 1 Yes Yes 0 6 2 2
I:I:?3 R:R:T145 8.13 1 Yes Yes 0 5 2 1
L:L:?1 R:R:F42 4.48 0 No Yes 0 3 1 2
L:L:?1 R:R:S302 5.52 0 No No 0 5 1 2
L:L:?1 W:W:?1 3.66 0 No Yes 0 0 1 0
R:R:P39 R:R:W70 5.4 1 Yes Yes 6 5 2 1
R:R:P39 R:R:T145 8.74 1 Yes Yes 6 5 2 1
R:R:R66 R:R:R69 5.33 1 Yes Yes 5 8 1 2
R:R:R66 R:R:W70 13 1 Yes Yes 5 5 1 1
R:R:R66 W:W:?1 6.99 1 Yes Yes 5 0 1 0
R:R:R66 W:W:?2 20.97 1 Yes Yes 5 0 1 2
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:R69 R:R:S417 3.95 1 Yes Yes 8 6 2 2
R:R:R69 W:W:?2 9.78 1 Yes Yes 8 0 2 2
R:R:T145 R:R:W70 6.06 1 Yes Yes 5 5 1 1
R:R:I416 R:R:W70 22.31 1 No Yes 4 5 1 1
R:R:S417 R:R:W70 4.94 1 Yes Yes 6 5 2 1
R:R:W70 W:W:?1 6.55 1 Yes Yes 5 0 1 0
R:R:W70 W:W:?2 10.48 1 Yes Yes 5 0 1 2
R:R:T145 R:R:Y167 6.24 1 Yes Yes 5 8 1 2
R:R:A168 R:R:T145 5.03 1 No Yes 5 5 1 1
R:R:T145 W:W:?1 5.3 1 Yes Yes 5 0 1 0
R:R:G146 W:W:?1 3.69 0 No Yes 5 0 1 0
R:R:S147 R:R:S169 4.89 1 Yes No 8 8 1 2
R:R:S147 R:R:S171 4.89 1 Yes No 8 7 1 2
R:R:S147 R:R:Y218 3.82 1 Yes Yes 8 7 1 1
R:R:S147 W:W:?1 6.48 1 Yes Yes 8 0 1 0
R:R:A168 W:W:?1 5.67 1 No Yes 5 0 1 0
R:R:I187 R:R:S170 6.19 0 No Yes 6 7 2 1
R:R:D190 R:R:S170 8.83 1 Yes Yes 8 7 2 1
R:R:S170 R:R:Y218 3.82 1 Yes Yes 7 7 1 1
R:R:S170 W:W:?1 7.56 1 Yes Yes 7 0 1 0
R:R:I187 R:R:L322 7.14 0 No No 6 4 2 2
R:R:D190 R:R:Q193 5.22 1 Yes Yes 8 9 2 2
R:R:D190 R:R:Y218 10.34 1 Yes Yes 8 7 2 1
R:R:D190 R:R:F270 4.78 1 Yes Yes 8 7 2 2
R:R:Q193 R:R:S296 4.33 1 Yes No 9 8 2 2
R:R:E297 R:R:Q193 3.82 0 No Yes 8 9 1 2
R:R:G219 R:R:Y218 4.35 0 No Yes 7 7 2 1
R:R:F270 R:R:Y218 5.16 1 Yes Yes 7 7 2 1
R:R:S296 R:R:Y218 6.36 1 No Yes 8 7 2 1
R:R:A298 R:R:Y218 5.34 1 No Yes 6 7 1 1
R:R:Y218 W:W:?1 23.6 1 Yes Yes 7 0 1 0
R:R:F270 R:R:S296 7.93 1 Yes No 7 8 2 2
R:R:E297 R:R:L322 15.9 0 No No 8 4 1 2
R:R:E297 W:W:?1 5.72 0 No Yes 8 0 1 0
R:R:A298 W:W:?1 9.06 1 No Yes 6 0 1 0
R:R:I416 W:W:?1 4.11 1 No Yes 4 0 1 0
R:R:I416 W:W:?2 8.21 1 No Yes 4 0 1 2
R:R:S417 W:W:?2 6.91 1 Yes Yes 6 0 2 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F684 R:R:S664 5.28 8 Yes No 8 6 1 2
R:R:F668 R:R:R680 21.38 0 No Yes 9 8 2 2
R:R:E837 R:R:F668 10.49 8 No No 9 9 1 2
R:R:F668 R:R:I841 3.77 0 No No 9 9 2 2
R:R:Q681 R:R:R680 4.67 0 Yes Yes 9 8 1 2
R:R:E767 R:R:Q681 14.02 0 No Yes 7 9 2 1
R:R:L773 R:R:Q681 3.99 0 No Yes 8 9 2 1
R:R:Q681 W:W:?3 13.41 0 Yes Yes 9 0 1 0
R:R:F684 R:R:F688 11.79 8 Yes Yes 8 8 1 2
R:R:F684 R:R:W818 6.01 8 Yes Yes 8 9 1 1
R:R:F684 R:R:I841 17.58 8 Yes No 8 9 1 2
R:R:F684 W:W:?3 14.16 8 Yes Yes 8 0 1 0
R:R:F688 R:R:F814 9.65 0 Yes Yes 8 9 2 1
R:R:T780 R:R:V689 4.76 8 No Yes 7 7 1 2
R:R:I777 R:R:L773 5.71 0 No No 8 8 1 2
R:R:I777 W:W:?3 15.48 0 No Yes 8 0 1 0
R:R:F814 R:R:T780 3.89 8 Yes No 9 7 1 1
R:R:T780 W:W:?3 4.57 8 No Yes 7 0 1 0
R:R:F814 R:R:F815 6.43 8 Yes Yes 9 7 1 2
R:R:F814 R:R:W818 10.02 8 Yes Yes 9 9 1 1
R:R:F814 W:W:?3 3.77 8 Yes Yes 9 0 1 0
R:R:A840 R:R:W818 9.08 0 No Yes 9 9 2 1
R:R:W818 W:W:?3 29.12 8 Yes Yes 9 0 1 0
R:R:I819 R:R:I822 4.42 0 No No 6 7 2 1
R:R:I822 W:W:?3 5.53 0 No Yes 7 0 1 0
R:R:V833 R:R:Y825 3.79 0 No No 6 9 2 1
R:R:E837 R:R:Y825 6.73 8 No No 9 9 1 1
R:R:Y825 W:W:?3 17.26 8 No Yes 9 0 1 0
R:R:E837 W:W:?3 20.54 8 No Yes 9 0 1 0
R:R:I822 R:R:P823 3.39 0 No Yes 7 9 1 2
R:R:Q681 R:R:W742 3.29 0 Yes Yes 9 9 1 2
R:R:C781 R:R:F814 2.79 8 No Yes 7 9 2 1
R:R:C781 R:R:F815 2.79 8 No Yes 7 7 2 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9AVG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.63
Number of Linked Nodes 1575
Number of Links 1890
Number of Hubs 282
Number of Links mediated by Hubs 1042
Number of Communities 57
Number of Nodes involved in Communities 455
Number of Links involved in Communities 640
Path Summary
Number Of Nodes in MetaPath 129
Number Of Links MetaPath 128
Number of Shortest Paths 10442095
Length Of Smallest Path 3
Average Path Length 57.5767
Length of Longest Path 108
Minimum Path Strength 1.21
Average Path Strength 7.71983
Maximum Path Strength 33.79
Minimum Path Correlation 0.71
Average Path Correlation 0.999294
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.6129
Average % Of Corr. Nodes 55.6468
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.6543
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • D2 dopamine receptor binding   • adenylate cyclase inhibitor activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • enzyme inhibitor activity   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • cell division   • leukocyte migration   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • negative regulation of peptide hormone secretion   • negative regulation of establishment of protein localization   • negative regulation of protein secretion   • negative regulation of signaling   • negative regulation of cell communication   • negative regulation of peptide secretion   • negative regulation of cellular process   • negative regulation of protein localization   • negative regulation of insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • ciliary basal body   • amino acid binding   • identical protein binding   • calcium ion binding   • phosphoric ester hydrolase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • phospholipase C activity   • phosphatidylinositol-4,5-bisphosphate phospholipase C activity   • phospholipase activity   • lipase activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • transmembrane transporter binding   • cell adhesion molecule binding   • integrin binding   • protein homodimerization activity   • protein dimerization activity   • kinase binding   • protein kinase binding   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of monoatomic ion transport   • metal ion transport   • calcium ion transport   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • tube development   • branching morphogenesis of an epithelial tube   • morphogenesis of an epithelium   • tissue morphogenesis   • tube morphogenesis   • morphogenesis of a branching structure   • epithelial tube morphogenesis   • morphogenesis of a branching epithelium   • regulation of tube diameter   • regulation of tube size   • regulation of system process   • positive regulation of vasoconstriction   • circulatory system process   • regulation of blood circulation   • vascular process in circulatory system   • regulation of vasoconstriction   • blood vessel diameter maintenance   • vasoconstriction   • blood circulation   • regulation of anatomical structure size   • monoatomic ion transmembrane transport   • chloride transport   • transmembrane transport   • chloride transmembrane transport   • monoatomic anion transport   • monoatomic anion transmembrane transport   • inorganic anion transport   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of gene expression   • regulation of macromolecule biosynthetic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • response to ischemia   • response to decreased oxygen levels   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • response to hypoxia   • response to oxygen levels   • response to abiotic stimulus   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • calcium ion homeostasis   • cellular homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • organic acid transport   • bile acid secretion   • organic anion transport   • monocarboxylic acid transport   • carboxylic acid transport   • acid secretion   • response to peptide   • cellular response to peptide   • behavior   • chemosensory behavior   • JNK cascade   • MAPK cascade   • cellular response to low-density lipoprotein particle stimulus   • response to lipoprotein particle   • cellular response to lipoprotein particle stimulus   • regulation of calcium ion import   • positive regulation of calcium ion transport   • positive regulation of calcium ion import   • positive regulation of transport   • positive regulation of monoatomic ion transport   • calcium ion import   • ossification   • connective tissue development   • adipose tissue development   • fat pad development   • response to fibroblast growth factor   • response to growth factor   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • cellular response to glucose stimulus   • intracellular glucose homeostasis   • response to hexose   • cellular response to carbohydrate stimulus   • response to monosaccharide   • response to carbohydrate   • response to glucose   • glucose homeostasis   • carbohydrate homeostasis   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • response to nutrient levels   • response to nutrient   • response to vitamin   • cellular response to vitamin D   • cellular response to nutrient levels   • response to vitamin D   • cellular response to vitamin   • cellular response to nutrient   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • vasodilation   • positive chemotaxis   • chemotaxis   • positive regulation of locomotion   • positive regulation of positive chemotaxis   • regulation of chemotaxis   • positive regulation of chemotaxis   • regulation of positive chemotaxis   • positive regulation of response to external stimulus   • taxis   • regulation of locomotion   • locomotion   • response to hepatocyte growth factor   • cellular response to growth factor stimulus   • cellular response to hepatocyte growth factor stimulus   • positive regulation of establishment of protein localization   • positive regulation of insulin secretion   • positive regulation of peptide hormone secretion   • positive regulation of secretion by cell   • positive regulation of protein transport   • positive regulation of hormone secretion   • positive regulation of secretion   • positive regulation of peptide secretion   • positive regulation of protein secretion   • detection of stimulus   • response to metal ion   • detection of chemical stimulus   • detection of calcium ion   • response to calcium ion   • presynapse   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse   • somatodendritic compartment   • cell body   • neuronal cell body   • apical part of cell   • apical plasma membrane   • cell surface   • axon   • axon terminus   • distal axon   • neuron projection terminus
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Type 1 solute binding protein-like   • TNF receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Type 1 solute binding protein-like   • TNF receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8 H:H:?9 H:H:?10 H:H:?11
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylglucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodeCA
PDB ResiduesI:I:?1 I:I:?2 I:I:?3 I:I:?4 L:L:?1 M:M:?1
Environment DetailsOpen EMBL-EBI Page
CodeCA
NameCALCIUM ION
Synonyms
Identifier
FormulaCa
Molecular Weight40.078
SMILES
PubChem
Formal Charge2
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

CodeTCR
PDB ResiduesW:W:?1 X:X:?1
Environment DetailsOpen EMBL-EBI Page
CodeTCR
NameCYCLOMETHYLTRYPTOPHAN
Synonyms
Identifier
FormulaC12 H12 N2 O2
Molecular Weight216.236
SMILES
PubChem449440
Formal Charge0
Total Atoms28
Total Chiral Atoms1
Total Bonds30
Total Aromatic Bonds10

CodePO4
PDB ResiduesW:W:?2 X:X:?2
Environment DetailsOpen EMBL-EBI Page
CodePO4
NamePhosphate ion
Synonyms
  • Orthophosphate
  • Phosphate ion
  • Phosphate
Identifier
FormulaO4 P
Molecular Weight94.971
SMILES
PubChem1061
Formal Charge-3
Total Atoms5
Total Chiral Atoms0
Total Bonds4
Total Aromatic Bonds0

Code9IG
PDB ResiduesW:W:?3 X:X:?3
Environment DetailsOpen EMBL-EBI Page
Code9IG
Name3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine
Synonyms
Identifier
FormulaC18 H22 Cl N O
Molecular Weight303.826
SMILES
PubChem158797
Formal Charge0
Total Atoms43
Total Chiral Atoms1
Total Bonds44
Total Aromatic Bonds12

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41180
Sequence
>9AVG_nogp_Chain_R
PDQRAQKKG DIILGGLFP IHFGVAAKD QDLKSRPES VECIRYNFR 
GFRWLQAMI FAIEEINSS PALLPNLTL GYRIFDTCN TVSKALEAT 
LSFVAQNKI DSIPSTIAV VGATGSGVS TAVANLLGL FYIPQVSYA 
SSSRLLSNK NQFKSFLRT IPNDEHQAT AMADIIEYF RWNWVGTIA 
ADDDYGRPG IEKFREEAE ERDICIDFS ELISQYSDE EEIQHVVEV 
IQNSTAKVI VVFSSGPDL EPLIKEIVR RNITGKIWL ASEAWASSS 
LIAMPQYFH VVGGTIGFA LKAGQIPGF REFLKKVHP RKSVHNGFA 
KEFWEETFN CHLRPLCTG DENISSVET PYIDYTHLR ISYNVYLAV 
YSIAHALQD IYTCLPGRG LFTNGSCAD IKKVEAWQV LKHLRHLNF 
TNNMGEQVT FDECGDLVG NYSIINWHL SPEDGSIVF KEVGYYNVY 
AKKGERLFI NEEKILWSG FSREVPFSN CSRDCLAGT RKGIIEGEP 
TCCFECVEC PDGEYSDET DASACNKCP DDFWSNENH TSCIAKEIE 
FLSWTEPFG IALTLFAVL GIFLTAFVL GVFIKFRNT PIVKATNRE 
LSYLLLFSL LCCFSSSLF FIGEPQDWT CRLRQPAFG ISFVLCISC 
ILVKTNRVL LVFEAKIPT SWWGLNLQF LLVFLCTFM QIVICVIWL 
YTAPPSSYR NQELEDEII FITCHEGSL MALGFLIGY TCLLAAICF 
FFAFKSRKL PENFNEAKF ITFSMLIFF IVWISFIPA YASTYGKFV 
SAVEVIAIL AASFGLLAC IFFNKIYII LFKP


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP41180
Sequence
>9AVG_nogp_Chain_S
GPDQRAQKK GDIILGGLF PIHFGVAAK DQDLKSRPE SVECIRYNF 
RGFRWLQAM IFAIEEINS SPALLPNLT LGYRIFDTC NTVSKALEA 
TLSFVAQNK IDSLIPSTI AVVGATGSG VSTAVANLL GLFYIPQVS 
YASSSRLLS NKNQFKSFL RTIPNDEHQ ATAMADIIE YFRWNWVGT 
IAADDDYGR PGIEKFREE AEERDICID FSELISQYS DEEEIQHVV 
EVIQNSTAK VIVVFSSGP DLEPLIKEI VRRNITGKI WLASEAWAS 
SSLIAMPQY FHVVGGTIG FALKAGQIP GFREFLKKV HPRKSVHNG 
FAKEFWEET FNCHLRPLC TGDENISSV ETPYIDYTH LRISYNVYL 
AVYSIAHAL QDIYTCLPG RGLFTNGSC ADIKKVEAW QVLKHLRHL 
NFTNNMGEQ VTFDECGDL VGNYSIINW HLSPEDGSI VFKEVGYYN 
VYAKKGERL FINEEKILW SGFSREVPF SNCSRDCLA GTRKGIIEG 
EPTCCFECV ECPDGEYSD ETDASACNK CPDDFWSNE NHTSCIAKE 
IEFLSWTEP FGIALTLFA VLGIFLTAF VLGVFIKFR NTPIVKATN 
RELSYLLLF SLLCCFSSS LFFIGEPQD WTCRLRQPA FGISFVLCI 
SCILVKTNR VLLVFEANL QFLLVFLCT FMQIVICVI WLYTAPPSS 
YRNQELEDE IIFITCHEG SLMALGFLI GYTCLLAAI CFFFAFKSR 
KLPENFNEA KFITFSMLI FFIVWISFI PAYASTYGK FVSAVEVIA 
ILAASFGLL ACIFFNKIY IILFKPSRN TIEEV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WPGCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca-2.72023-11-22doi.org/10.1038/s41422-023-00892-2
8WPUCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(NtGi2L-Gs-CtGq)/β1/γ23.12023-11-22doi.org/10.1038/s41422-023-00892-2
8WPU (No Gprot) CIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca3.12023-11-22doi.org/10.1038/s41422-023-00892-2
7DTUCIonCalcium SensingCaSHomo sapiens-Tryptophan-4.42021-03-10doi.org/10.1038/s41422-021-00474-0
7M3JCIonCalcium SensingCaSHomo sapiens-NPS-2143; PO4-4.12021-06-30doi.org/10.1038/s41586-021-03691-0
7SINCIonCalcium SensingCaSHomo sapiens-NPS-2143-5.92022-01-19doi.org/10.1073/pnas.2115849118
9C1PCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan; '6218; PO4-2.82024-10-02doi.org/10.1126/science.ado1868
7DTVCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan-3.52021-03-10doi.org/10.1038/s41422-021-00474-0
7M3ECIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; NPS-2143-3.22021-06-30doi.org/10.1038/s41586-021-03691-0
7DD5CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; NPS-2143-3.22021-06-16doi.org/10.1126/sciadv.abg1483
7M3GCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4-2.52021-06-30doi.org/10.1038/s41586-021-03691-0
7DD7CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; Evocalcet-3.22021-06-16doi.org/10.1126/sciadv.abg1483
8SZFCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-2.82024-02-07doi.org/10.1038/s41586-024-07055-2
8SZGCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Sperminechim(NtGi1-Gq)/β1/γ23.62024-02-07doi.org/10.1038/s41586-024-07055-2
8SZG (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine3.62024-02-07doi.org/10.1038/s41586-024-07055-2
8SZHCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; SpermineGi1/β1/γ23.12024-02-07doi.org/10.1038/s41586-024-07055-2
8SZH (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine3.12024-02-07doi.org/10.1038/s41586-024-07055-2
7M3FCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4-2.82021-06-30doi.org/10.1038/s41586-021-03691-0
8SZICIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4Gi3/β1/γ23.52024-02-07doi.org/10.1038/s41586-024-07055-2
8SZI (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO43.52024-02-07doi.org/10.1038/s41586-024-07055-2
9C2FCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Tryptophan; '54149; PO4-2.82024-10-02doi.org/10.1126/science.ado1868
7DD6CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan-3.22021-06-16doi.org/10.1126/sciadv.abg1483
7SIMCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-2.72022-01-19doi.org/10.1073/pnas.2115849118
7E6TCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-32021-09-22doi.org/10.7554/eLife.68578
9ASBCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.42024-04-17doi.org/10.1038/s41586-024-07331-1
9ASB (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.42024-04-17doi.org/10.1038/s41586-024-07331-1
9AVGCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs)/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AVG (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AVLCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4Gi3/β2/γ23.82024-04-17doi.org/10.1038/s41586-024-07331-1
9AVL (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.82024-04-17doi.org/10.1038/s41586-024-07331-1
9AXFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.52024-04-17doi.org/10.1038/s41586-024-07331-1
9AXF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.52024-04-17doi.org/10.1038/s41586-024-07331-1
9AYFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4Gi1/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AYF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-17doi.org/10.1038/s41586-024-07331-1
7SILCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-2.72022-01-19doi.org/10.1073/pnas.2115849118
7DTTCIonCalcium SensingCaSHomo sapiensCaCa-3.82021-03-10doi.org/10.1038/s41422-021-00474-0
7DTWCIonCalcium SensingCaSHomo sapiens---4.52021-03-10doi.org/10.1038/s41422-021-00474-0
7E6UCIonCalcium SensingCaSHomo sapiens---62021-09-22doi.org/10.7554/eLife.68578




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9AVG_nogp.zip



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