Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1H:H:?1 17.726130
2H:H:?3 15.81676170
3H:H:?5 15.9345280
4H:H:?10 16.9154310
5X:X:?2 7.68429720
6X:X:?3 8.3209111180
7R:R:I32 4.67254416
8R:R:F38 5.504517
9R:R:I40 4.95415
10R:R:H41 6.758517
11R:R:F42 7.744423
12R:R:P55 5.712596
13R:R:Y63 7.724515
14R:R:F65 5.48512
15R:R:R66 8.06415
16R:R:F68 6.7175417
17R:R:R69 6.3875418
18R:R:W70 7.91615
19R:R:Q72 5.0625417
20R:R:M74 3.33333618
21R:R:Y95 6.6175408
22R:R:R96 3.9625244
23R:R:I97 4.17518
24R:R:F98 5.966676244
25R:R:C101 5.2775418
26R:R:F114 3.446505
27R:R:T145 3.98615
28R:R:V153 3.344546
29R:R:L157 3.182547
30R:R:F160 7.5125407
31R:R:P163 3.7775408
32R:R:Q164 4.83548
33R:R:Y167 4.915618
34R:R:R172 5.77404
35R:R:L173 5.5175405
36R:R:L174 6.825447
37R:R:Q179 4.785445
38R:R:F180 5.184545
39R:R:F183 7.4475448
40R:R:R185 6.216549
41R:R:I200 3.145408
42R:R:F204 8.71467
43R:R:W206 7.046569
44R:R:W208 5.974297199
45R:R:T211 4.8875405
46R:R:Y218 4.0525817
47R:R:K225 6.54403
48R:R:F226 2.6225406
49R:R:R227 6.8285324
50R:R:E229 4.6775405
51R:R:R233 6.042504
52R:R:I235 3.68407
53R:R:F239 4.8665196
54R:R:Q245 5.305404
55R:R:F270 4.428507
56R:R:P274 3.7065423
57R:R:D275 3.97754145
58R:R:L276 5.0454145
59R:R:E282 7.695336
60R:R:L294 2.8825407
61R:R:W299 7.324147
62R:R:L304 4.754422
63R:R:I305 3.715144
64R:R:Y310 4.388503
65R:R:V313 3.375403
66R:R:I327 5.172516
67R:R:F330 6.01518
68R:R:L334 5.535616
69R:R:F351 6.19571716
70R:R:W352 11.3625418
71R:R:E353 6.0854457
72R:R:T355 5.0825414
73R:R:F356 9.948518
74R:R:E399 7.59418
75R:R:Y408 6.57167613
76R:R:Y411 6.94415
77R:R:L414 3.9225416
78R:R:R415 4.69415
79R:R:Y418 6.70167617
80R:R:Y421 8.072518
81R:R:L443 2.744103
82R:R:F444 3.7045103
83R:R:W458 7.575104
84R:R:Q459 6.625107
85R:R:K462 5.3485104
86R:R:H463 4.1075405
87R:R:N471 4.42716
88R:R:M473 4.828514
89R:R:W494 7.684347
90R:R:S497 2.7156463
91R:R:F505 5.5885344
92R:R:Y511 5.885405
93R:R:N512 8.33254134
94R:R:V513 3.1025133
95R:R:Y514 7.21754134
96R:R:W530 8.37833668
97R:R:V537 3.74464
98R:R:C546 4.144209
99R:R:T550 3.1854206
100R:R:R551 7.6975407
101R:R:K552 7.60754208
102R:R:F563 7.2754207
103R:R:D578 6.4685207
104R:R:W590 7.6275406
105R:R:N592 6.7354477
106R:R:C598 4.74369
107R:R:W608 7.545405
108R:R:V633 2.845475
109R:R:F637 3.8125474
110R:R:T640 4.184509
111R:R:E649 4.824377
112R:R:Y652 3.244577
113R:R:L658 4.6408
114R:R:F662 5.0445488
115R:R:W675 5.074493
116R:R:R678 3.7425405
117R:R:F684 7.296508
118R:R:F688 5.5775458
119R:R:F706 3.7165259
120R:R:W719 7.7585516
121R:R:Q724 8.0925378
122R:R:V728 3.21507
123R:R:Q735 8.296559
124R:R:I738 2.175458
125R:R:W742 5.67409
126R:R:E757 10.4025434
127R:R:I760 4.015435
128R:R:F762 6.47437
129R:R:L773 6.4975458
130R:R:F788 5.175408
131R:R:F790 3.86754507
132R:R:F801 3.01254259
133R:R:I807 4.7575409
134R:R:M811 3.878509
135R:R:F814 5.78833659
136R:R:F821 3.83143709
137R:R:Y829 7.62333636
138R:R:V838 3.635407
139R:R:F853 4.6425479
140R:R:I860 3.67579
141R:R:K863 5.9325407
142S:S:I32 4.6045536
143S:S:F38 5.054527
144S:S:H41 7.2265117
145S:S:F42 9.1854543
146S:S:V44 3.64754112
147S:S:Y63 7.7445115
148S:S:F68 7.025427
149S:S:W70 7.9525425
150S:S:L71 4.572524
151S:S:Q72 4.44667627
152S:S:M74 3.42528
153S:S:I75 5.45424
154S:S:F76 5.8375427
155S:S:I81 3.902509
156S:S:L91 3.86754536
157S:S:L93 3.16254539
158S:S:Y95 5.642508
159S:S:I97 5.015428
160S:S:F98 5.871676214
161S:S:C101 4.894118
162S:S:V104 3.365444
163S:S:F114 3.8545215
164S:S:T145 4425
165S:S:T151 3.58425
166S:S:V153 4.51426
167S:S:L157 2.884527
168S:S:F160 4.7675407
169S:S:P163 2.876558
170S:S:Q164 5.38428
171S:S:Y167 4.905628
172S:S:L173 5.3145445
173S:S:L174 7.1925427
174S:S:F180 6.745425
175S:S:F183 7.46428
176S:S:R185 4.83167629
177S:S:I187 3.112526
178S:S:I200 3.125488
179S:S:I201 2.8425406
180S:S:F204 6.8687
181S:S:W208 6.187147229
182S:S:T211 4.4875405
183S:S:Y218 3.788758407
184S:S:K225 4.1775403
185S:S:F226 2.652506
186S:S:R227 8.06754324
187S:S:E229 6.4325405
188S:S:R233 7.5375404
189S:S:F239 5.0945226
190S:S:V258 4.855404
191S:S:V269 4.77254235
192S:S:F270 5.485407
193S:S:P274 3.7065543
194S:S:D275 3.9775405
195S:S:L276 5.395235
196S:S:E277 6.6025402
197S:S:E282 6.6225266
198S:S:R286 8.00754264
199S:S:W293 5.32254568
200S:S:E297 4.0525428
201S:S:W299 8.47754237
202S:S:L304 4.72254542
203S:S:I305 4.454234
204S:S:Y310 5.17403
205S:S:F320 5.01586
206S:S:I327 3.855626
207S:S:F330 5.1425428
208S:S:F333 6.8575427
209S:S:L334 4.985426
210S:S:P339 10.3675407
211S:S:N345 3.562528
212S:S:F347 2.658525
213S:S:F351 7.00333626
214S:S:W352 10.668528
215S:S:F356 12.7875428
216S:S:R392 2.4125401
217S:S:Y408 7.552523
218S:S:L414 5.21426
219S:S:Y418 5.986527
220S:S:Y421 7.855428
221S:S:F444 4.295693
222S:S:W458 8.034594
223S:S:Q459 7.314597
224S:S:L461 4.805407
225S:S:K462 4.9725494
226S:S:H463 6.6725405
227S:S:L464 3.394557
228S:S:F469 7.7025588
229S:S:N471 6.0554586
230S:S:M473 4.005424
231S:S:I491 3.8075488
232S:S:W494 8.0265397
233S:S:S497 2.8725403
234S:S:I503 5.13754394
235S:S:F505 6.2754394
236S:S:V508 3.1425407
237S:S:N512 6.2745314
238S:S:I523 4.5525486
239S:S:W530 8.044588
240S:S:K552 6.4225158
241S:S:I554 3.0475403
242S:S:F563 7.225157
243S:S:P569 4.91754355
244S:S:D578 6.74254157
245S:S:C582 4.94754359
246S:S:E610 5.0175407
247S:S:V633 5.2954165
248S:S:F637 4.15254164
249S:S:T640 3.318336169
250S:S:I642 3.6665167
251S:S:N647 4.43254129
252S:S:F662 4.796608
253S:S:F668 6.2175409
254S:S:W675 7.2754273
255S:S:R678 5.7685275
256S:S:R680 6.47408
257S:S:Q681 8.544189
258S:S:F684 8.9625408
259S:S:F688 6.076508
260S:S:V697 2.984128
261S:S:N700 7.04254627
262S:S:L704 2.311676128
263S:S:N753 5.65254637
264S:S:I760 6.56535
265S:S:F762 4.3454637
266S:S:F790 3.8325407
267S:S:L797 4.4554628
268S:S:F814 7.2525409
269S:S:V817 2.92409
270S:S:W818 7.016676189
271S:S:F821 6.90254189
272S:S:F832 4.4475435
273S:S:L842 2.244509
274S:S:F853 4.876619
275S:S:K856 3.54409
276S:S:I860 4.89754169
277W:W:?1 10.1578950
278W:W:W5 5.122510
279W:W:?6 6.86610
280X:X:?4 9.134530
281W:W:?8 13.964530
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I235 R:R:V209 99.00133.07YesNo078
2R:R:G210 R:R:V209 99.44743.68NoNo088
3R:R:F239 R:R:G210 99.40869.03YesNo068
4R:R:D238 R:R:F239 1003.58NoYes1986
5R:R:D238 R:R:W208 99.977313.4NoYes1989
6R:R:C236 R:R:W208 99.65292.61NoYes099
7R:R:C236 R:R:C561 99.61227.28NoNo099
8R:R:C561 R:R:N207 99.57166.3NoNo096
9H:H:?3 R:R:N207 99.355911.09YesNo1706
10H:H:?3 R:R:D545 99.169510.96YesNo005
11R:R:I237 R:R:T211 29.77114.56NoYes065
12R:R:I237 R:R:R227 29.73573.76NoYes064
13R:R:R227 S:S:R227 59.218718.13YesYes3244
14S:S:I237 S:S:R227 59.07742.51NoYes064
15S:S:I237 S:S:T211 58.99684.56NoYes065
16S:S:F226 S:S:T211 13.94792.59YesYes065
17S:S:F226 S:S:I201 11.47732.51YesYes066
18S:S:I201 S:S:V209 10.03973.07YesNo068
19R:R:I201 R:R:I235 56.97055.89NoYes067
20R:R:F226 R:R:I201 42.8972.51YesNo066
21R:R:F226 R:R:T211 56.72972.59YesYes065
22R:R:A230 R:R:I235 42.34093.25NoYes067
23R:R:A230 R:R:F226 42.34652.77NoYes066
24R:R:S240 R:R:T211 29.77114.8NoYes045
25R:R:R227 R:R:S240 29.73575.27YesNo044
26R:R:F270 R:R:S296 46.57195.28YesNo078
27R:R:S296 R:R:Y218 46.51632.54NoYes087
28S:S:I223 S:S:T211 44.89297.6NoYes055
29S:S:F270 S:S:I223 44.73317.54YesNo075
30S:S:F270 S:S:M197 45.52147.46YesNo077
31S:S:F320 S:S:M197 45.44584.98YesNo067
32S:S:F320 S:S:Q193 44.36675.86YesNo069
33S:S:D190 S:S:Q193 22.18595.22NoNo089
34S:S:D190 S:S:Y218 22.02675.75NoYes4087
35S:S:Y218 X:X:W1 41.09713.86YesNo070
36S:S:A168 X:X:W1 23.20763.89NoNo050
37S:S:Q193 S:S:S296 22.10457.22NoNo098
38S:S:S296 S:S:Y218 22.02673.82NoYes087
39S:S:E297 X:X:W1 18.36185.45YesNo080
40S:S:A168 S:S:Y167 22.33652.67NoYes258
41S:S:E297 S:S:I416 11.02292.73YesNo284
42S:S:I416 X:X:?2 10.19888.21NoYes240
43R:R:D545 R:R:D578 99.12879.31NoYes057
44R:R:C546 R:R:D578 97.19293.11YesYes2097
45R:R:C546 R:R:T550 97.84273.38YesYes2096
46R:R:E567 R:R:T550 97.77512.82NoYes046
47R:R:E567 R:R:H595 97.73272.46NoNo045
48R:R:H595 R:R:S591 97.6484.18NoNo058
49R:R:G571 R:R:S591 97.60563.71NoNo078
50R:R:G571 R:R:W590 97.56328.44NoYes076
51R:R:E759 R:R:W590 97.435814.17NoYes046
52R:R:E759 R:R:I760 97.39332.73NoYes045
53R:R:E757 R:R:I760 65.41646.83YesYes345
54R:R:E757 R:R:Y829 31.40517.86YesYes346
55R:R:Y829 X:X:?4 62.594212.38YesYes360
56R:R:T828 X:X:?4 93.71282.83NoYes380
57R:R:S827 R:R:T828 93.54474.8NoNo388
58R:R:S827 S:S:T828 45.43364.8NoNo388
59S:S:T828 S:S:V833 45.29913.17NoNo086
60S:S:V833 S:S:Y825 45.12516.31NoNo069
61S:S:Y825 X:X:?3 42.26255.13NoYes1890
62R:R:F762 R:R:I760 31.51863.77YesYes375
63R:R:F762 R:R:Y829 31.41153.09YesYes376
64R:R:E757 W:W:?8 33.904121.62YesYes340
65W:W:?8 X:X:?4 31.43567.65YesYes300
66S:S:F684 X:X:?3 25.370115.11YesYes080
67R:R:S827 S:S:F832 47.93775.28NoYes385
68R:R:P823 S:S:F832 47.58494.33NoYes095
69R:R:P823 S:S:V836 47.23875.3NoNo098
70S:S:E837 X:X:?3 10.07365.8NoYes090
71R:R:Y218 W:W:W5 45.57634.82YesYes170
72R:R:E297 W:W:W5 24.67246.54NoYes080
73R:R:E297 R:R:L322 24.635.3NoNo084
74R:R:I187 R:R:L322 24.57622.85NoNo064
75R:R:I187 R:R:R185 24.56532.51NoYes069
76R:R:F183 R:R:R185 18.73434.28YesYes489
77R:R:F183 R:R:Q164 18.83579.37YesYes488
78R:R:L157 R:R:Q164 10.89022.66YesYes478
79R:R:R66 W:W:W5 21.31513YesYes150
80R:R:R66 R:R:R69 17.14044.26YesYes158
81R:R:L334 R:R:R69 13.64473.64YesYes168
82R:R:L156 R:R:T111 12.28525.9NoNo057
83R:R:L112 R:R:L156 12.17571.38NoNo055
84R:R:L112 S:S:L112 12.06821.38NoNo055
85S:S:L112 S:S:L156 11.96132.77NoNo055
86S:S:L156 S:S:T111 11.86354.42NoNo057
87S:S:L157 S:S:T111 10.40192.95YesNo277
88R:R:I201 R:R:L294 15.192.85NoYes067
89R:R:F270 R:R:V268 43.91332.62YesNo076
90S:S:A824 S:S:V836 45.21351.7NoNo078
91R:R:F821 S:S:A824 45.0332.77YesNo097
92R:R:A840 R:R:F821 43.40752.77NoYes099
93R:R:A840 R:R:W818 43.22689.08NoNo099
94R:R:W818 W:W:?1 18.317525.77NoYes590
95R:R:F684 W:W:?1 10.727814.22YesYes080
96R:R:F684 R:R:I841 10.32037.54YesNo089
97R:R:F668 R:R:I841 10.13332.51NoNo099
98R:R:F814 R:R:W818 24.72868.02YesNo599
99R:R:F814 R:R:M811 23.13.73YesYes099
100R:R:C787 R:R:M811 21.52913.24NoYes089
101R:R:C787 R:R:I807 21.34468.18NoYes089
102R:R:I695 R:R:I807 20.98162.94NoYes079
103R:R:I695 R:R:I852 20.79712.94NoNo079
104R:R:F853 R:R:I852 12.08943.77YesNo099
105S:S:F684 S:S:F688 21.57286.43YesYes088
106S:S:F688 S:S:L848 15.81693.65YesNo087
107S:S:L848 S:S:S810 15.63173NoNo079
108S:S:I852 S:S:S810 15.26123.1NoNo099
109S:S:F38 S:S:Y167 19.701910.32YesYes278
110S:S:F38 S:S:L71 16.97546.09YesYes274
111S:S:L71 S:S:Q72 12.2072.66YesYes247
112R:R:F226 R:R:V268 29.63072.62YesNo066
113R:R:L294 R:R:V268 15.44332.98YesNo076
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E757 R:R:L756 5.3 3 Yes No 4 5 2 2
R:R:F762 R:R:L756 8.53 3 Yes No 7 5 2 2
R:R:L756 R:R:Y829 17.58 3 No Yes 5 6 2 1
R:R:E757 R:R:Y829 7.86 3 Yes Yes 4 6 2 1
R:R:E757 W:W:?8 21.62 3 Yes Yes 4 0 2 1
R:R:F762 R:R:Y829 3.09 3 Yes Yes 7 6 2 1
R:R:S827 R:R:T828 4.8 3 No No 8 8 2 1
R:R:T828 S:S:Y829 3.75 3 No No 8 6 1 1
R:R:T828 X:X:?4 2.83 3 No Yes 8 0 1 0
R:R:Y829 X:X:?4 12.38 3 Yes Yes 6 0 1 0
R:R:Y829 W:W:?8 3.38 3 Yes Yes 6 0 1 1
R:R:F832 R:R:K831 4.96 0 No No 5 9 1 2
R:R:F832 S:S:S827 5.28 0 No No 5 8 1 2
R:R:F832 X:X:?4 8.18 0 No Yes 5 0 1 0
S:S:E757 S:S:I760 5.47 3 No Yes 4 5 2 2
S:S:E757 W:W:?8 33.06 3 No Yes 4 0 2 1
S:S:I760 W:W:?8 4.11 3 Yes Yes 5 0 2 1
S:S:Y829 X:X:?4 14.63 3 No Yes 6 0 1 0
W:W:?8 X:X:?4 7.65 3 Yes Yes 0 0 1 0
R:R:G830 R:R:Y829 1.45 0 No Yes 8 6 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:A168 X:X:W1 3.89 2 No No 5 0 1 0
S:S:Y218 X:X:W1 3.86 40 Yes No 7 0 1 0
S:S:E297 X:X:W1 5.45 2 Yes No 8 0 1 0
S:S:T145 S:S:Y167 3.75 2 Yes Yes 5 8 2 2
S:S:A168 S:S:T145 3.36 2 No Yes 5 5 1 2
S:S:S147 S:S:Y218 2.54 0 No Yes 8 7 2 1
S:S:A168 S:S:Y167 2.67 2 No Yes 5 8 1 2
S:S:D190 S:S:S170 8.83 40 No No 8 7 2 2
S:S:S170 S:S:Y218 2.54 40 No Yes 7 7 2 1
S:S:E297 S:S:I187 2.73 2 Yes Yes 8 6 1 2
S:S:I187 S:S:L322 2.85 2 Yes No 6 4 2 2
S:S:D190 S:S:Y218 5.75 40 No Yes 8 7 2 1
S:S:D216 S:S:Y218 3.45 0 No Yes 6 7 2 1
S:S:G219 S:S:Y218 4.35 0 No Yes 7 7 2 1
S:S:S296 S:S:Y218 3.82 0 No Yes 8 7 2 1
S:S:A298 S:S:Y218 4 0 No Yes 6 7 2 1
S:S:E297 S:S:L322 5.3 2 Yes No 8 4 1 2
S:S:E297 S:S:I416 2.73 2 Yes No 8 4 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:Q681 X:X:?3 16.51 18 Yes Yes 9 0 1 0
S:S:F684 X:X:?3 15.11 0 Yes Yes 8 0 1 0
S:S:L770 X:X:?3 3.03 0 No Yes 3 0 1 0
S:S:L773 X:X:?3 6.06 18 No Yes 8 0 1 0
S:S:L776 X:X:?3 4.04 0 No Yes 8 0 1 0
S:S:I777 X:X:?3 11.46 0 No Yes 8 0 1 0
S:S:T780 X:X:?3 7.53 0 No Yes 7 0 1 0
S:S:W818 X:X:?3 13.3 18 Yes Yes 9 0 1 0
S:S:F821 X:X:?3 3.56 18 Yes Yes 9 0 1 0
S:S:Y825 X:X:?3 5.13 18 No Yes 9 0 1 0
S:S:E837 X:X:?3 5.8 0 No Yes 9 0 1 0
S:S:E837 S:S:F668 10.49 0 No Yes 9 9 1 2
S:S:P682 S:S:Q681 4.74 0 No Yes 5 9 2 1
S:S:E767 S:S:Q681 8.92 0 No Yes 7 9 2 1
S:S:L773 S:S:Q681 3.99 18 No Yes 8 9 1 1
S:S:F684 S:S:G685 3.01 0 Yes No 8 8 1 2
S:S:F684 S:S:F688 6.43 0 Yes Yes 8 8 1 2
S:S:F684 S:S:I841 11.3 0 Yes No 8 9 1 2
S:S:F688 S:S:F814 8.57 0 Yes Yes 8 9 2 2
S:S:L776 S:S:Q735 3.99 0 No No 8 9 1 2
S:S:F814 S:S:W818 8.02 0 Yes Yes 9 9 2 1
S:S:V817 S:S:W818 3.68 0 Yes Yes 9 9 2 1
S:S:F821 S:S:W818 8.02 18 Yes Yes 9 9 1 1
S:S:A840 S:S:W818 7.78 0 No Yes 9 9 2 1
S:S:F821 S:S:Y825 13.41 18 Yes No 9 9 1 1
S:S:F821 S:S:V836 2.62 18 Yes No 9 8 1 2
S:S:V833 S:S:Y825 6.31 0 No No 6 9 2 1
S:S:G778 S:S:I777 1.76 0 No No 5 8 2 1
S:S:G774 S:S:L773 1.71 0 No No 4 8 2 1
S:S:A844 S:S:W818 1.3 0 No Yes 9 9 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8SZG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.51
Number of Linked Nodes 1555
Number of Links 1848
Number of Hubs 281
Number of Links mediated by Hubs 1057
Number of Communities 63
Number of Nodes involved in Communities 440
Number of Links involved in Communities 598
Path Summary
Number Of Nodes in MetaPath 114
Number Of Links MetaPath 113
Number of Shortest Paths 11945204
Length Of Smallest Path 3
Average Path Length 52.1729
Length of Longest Path 91
Minimum Path Strength 1.21
Average Path Strength 5.44715
Maximum Path Strength 32.06
Minimum Path Correlation 0.7
Average Path Correlation 0.99915
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 55.2877
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.0412
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • amino acid binding   • identical protein binding   • cation binding   • ion binding   • calcium ion binding   • metal ion binding   • small molecule binding   • phosphoric ester hydrolase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • phospholipase C activity   • hydrolase activity   • phosphatidylinositol-4,5-bisphosphate phospholipase C activity   • catalytic activity   • phospholipase activity   • lipase activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • transmembrane transporter binding   • cell adhesion molecule binding   • protein-containing complex binding   • integrin binding   • signaling receptor binding   • protein homodimerization activity   • protein dimerization activity   • kinase binding   • enzyme binding   • protein kinase binding   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • developmental process   • multicellular organismal process   • epithelium development   • tube development   • branching morphogenesis of an epithelial tube   • morphogenesis of an epithelium   • tissue development   • tissue morphogenesis   • anatomical structure morphogenesis   • multicellular organism development   • tube morphogenesis   • morphogenesis of a branching structure   • anatomical structure development   • epithelial tube morphogenesis   • morphogenesis of a branching epithelium   • regulation of tube diameter   • system process   • regulation of tube size   • regulation of system process   • positive regulation of biological process   • positive regulation of vasoconstriction   • circulatory system process   • regulation of blood circulation   • vascular process in circulatory system   • regulation of vasoconstriction   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • blood vessel diameter maintenance   • vasoconstriction   • blood circulation   • regulation of anatomical structure size   • monoatomic ion transmembrane transport   • chloride transport   • transmembrane transport   • chloride transmembrane transport   • monoatomic anion transport   • monoatomic anion transmembrane transport   • inorganic anion transport   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • response to stress   • response to ischemia   • response to decreased oxygen levels   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to stress   • response to hypoxia   • response to oxygen levels   • response to abiotic stimulus   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • organic acid transport   • bile acid secretion   • organic anion transport   • monocarboxylic acid transport   • carboxylic acid transport   • secretion   • acid secretion   • response to peptide   • cellular response to peptide   • behavior   • chemosensory behavior   • intracellular signal transduction   • JNK cascade   • intracellular signaling cassette   • MAPK cascade   • cellular response to low-density lipoprotein particle stimulus   • response to lipoprotein particle   • cellular response to lipoprotein particle stimulus   • phospholipase C-activating G protein-coupled receptor signaling pathway   • regulation of calcium ion import   • positive regulation of calcium ion transport   • positive regulation of calcium ion import   • positive regulation of transport   • positive regulation of monoatomic ion transport   • calcium ion import   • ossification   • connective tissue development   • adipose tissue development   • fat pad development   • animal organ development   • response to fibroblast growth factor   • response to growth factor   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • cellular response to glucose stimulus   • intracellular glucose homeostasis   • response to hexose   • cellular response to carbohydrate stimulus   • response to monosaccharide   • response to carbohydrate   • response to glucose   • glucose homeostasis   • carbohydrate homeostasis   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • response to nutrient levels   • response to nutrient   • response to vitamin   • cellular response to vitamin D   • cellular response to nutrient levels   • response to vitamin D   • cellular response to vitamin   • cellular response to nutrient   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • vasodilation   • positive chemotaxis   • chemotaxis   • positive regulation of locomotion   • regulation of response to external stimulus   • positive regulation of positive chemotaxis   • response to external stimulus   • regulation of chemotaxis   • positive regulation of chemotaxis   • regulation of positive chemotaxis   • positive regulation of response to external stimulus   • taxis   • regulation of locomotion   • locomotion   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to hepatocyte growth factor   • cellular response to growth factor stimulus   • cellular response to hepatocyte growth factor stimulus   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • positive regulation of insulin secretion   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • regulation of protein secretion   • regulation of secretion   • positive regulation of protein localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • positive regulation of secretion   • amide transport   • signal release   • positive regulation of peptide secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • detection of stimulus   • response to metal ion   • detection of chemical stimulus   • detection of calcium ion   • response to calcium ion   • presynapse   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse   • somatodendritic compartment   • cell body   • neuronal cell body   • apical part of cell   • apical plasma membrane   • cell surface   • axon   • axon terminus   • distal axon   • neuron projection terminus   • GTPase regulator activity   • enzyme regulator activity   • enzyme activator activity   • GTPase activator activity   • molecular function activator activity   • nucleoside-triphosphatase regulator activity   • molecular function regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity, acting on acid anhydrides   • G protein-coupled receptor binding   • D2 dopamine receptor binding   • dopamine receptor binding   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • cell surface receptor signaling pathway   • regulation of Wnt signaling pathway   • regulation of canonical Wnt signaling pathway   • canonical Wnt signaling pathway   • Wnt signaling pathway   • neuropeptide signaling pathway   • regulation of body fluid levels   • wound healing   • hemostasis   • blood coagulation   • coagulation   • response to wounding   • regulation of protein stability   • protein stabilization   • phospholipase C-activating serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • rhythmic process   • entrainment of circadian clock   • circadian rhythm   • regulation of circadian rhythm   • glutamate receptor signaling pathway   • detection of light stimulus   • response to light stimulus   • phototransduction   • detection of external stimulus   • detection of visible light   • detection of abiotic stimulus   • response to radiation   • phototransduction, visible light   • cell activation   • regulation of cell activation   • regulation of platelet activation   • platelet activation   • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway   • G protein-coupled glutamate receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • regulation of small molecule metabolic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • negative regulation of biological process   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • negative regulation of peptide hormone secretion   • negative regulation of establishment of protein localization   • negative regulation of protein secretion   • negative regulation of signaling   • negative regulation of cell communication   • negative regulation of peptide secretion   • negative regulation of cellular process   • negative regulation of protein localization   • negative regulation of insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • nuclear membrane   • nucleus   • endomembrane system   • organelle envelope   • nuclear envelope   • Golgi apparatus   • cytosolic region   • postsynapse   • postsynaptic cytosol   • midbody   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • ciliary basal body
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • TNF receptor-like   • Type 1 solute binding protein-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • TNF receptor-like   • Type 1 solute binding protein-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8 H:H:?9 H:H:?10
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylglucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodePO4
PDB ResiduesX:X:?2 W:W:?6
Environment DetailsOpen EMBL-EBI Page
CodePO4
NamePhosphate ion
Synonyms
  • Orthophosphate
  • Phosphate ion
  • Phosphate
Identifier
FormulaO4 P
Molecular Weight94.971
SMILES
PubChem1061
Formal Charge-3
Total Atoms5
Total Chiral Atoms0
Total Bonds4
Total Aromatic Bonds0

CodeYP4
PDB ResiduesX:X:?3 W:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeYP4
NameCinacalcet
Synonyms
  • (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine
  • Cinacalcet
  • Cinacalcet hydrochloride
  • CNC
  • N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine
Identifier
FormulaC22 H22 F3 N
Molecular Weight357.412
SMILES
PubChem156419
Formal Charge0
Total Atoms48
Total Chiral Atoms1
Total Bonds50
Total Aromatic Bonds17

CodeCA
PDB ResiduesW:W:?3 W:W:?4 W:W:?7
Environment DetailsOpen EMBL-EBI Page
CodeCA
NameCALCIUM ION
Synonyms
Identifier
FormulaCa
Molecular Weight40.078
SMILES
PubChem
Formal Charge2
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

CodeSPM
PDB ResiduesX:X:?4 W:W:?8
Environment DetailsOpen EMBL-EBI Page
CodeSPM
NameSpermine
Synonyms4,9-diazadodecane-1,12-diamine
Identifier
FormulaC10 H26 N4
Molecular Weight202.34
SMILES
PubChem1103
Formal Charge0
Total Atoms40
Total Chiral Atoms0
Total Bonds39
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41180
Sequence
>8SZG_nogp_Chain_R
YGPDQRAQK KGDIILGGL FPIHFGVAA KDQDLKSRP ESVECIRYN 
FRGFRWLQA MIFAIEEIN SSPALLPNL TLGYRIFDT CNTVSKALE 
ATLSFVAQN KIHIPSTIA VVGATGSGV STAVANLLG LFYIPQVSY 
ASSSRLLSN KNQFKSFLR TIPNDEHQA TAMADIIEY FRWNWVGTI 
AADDDYGRP GIEKFREEA EERDICIDF SELISQYSD EEEIQHVVE 
VIQNSTAKV IVVFSSGPD LEPLIKEIV RRNITGKIW LASEAWASS 
SLIAMPQYF HVVGGTIGF ALKAGQIPG FREFLKKVH PRKSVHNGF 
AKEFWEETF NCHLQEFRP LCTGDENIS SVETPYIDY THLRISYNV 
YLAVYSIAH ALQDIYTCL PGRGLFTNG SCADIKKVE AWQVLKHLR 
HLNFTNNMG EQVTFDECG DLVGNYSII NWHLSPEDG SIVFKEVGY 
YNVYAKKGE RLFINEEKI LWSGFSREV PFSNCSRDC LAGTRKGII 
EGEPTCCFE CVECPDGEY SDETDASAC NKCPDDFWS NENHTSCIA 
KEIEFLSWT EPFGIALTL FAVLGIFLT AFVLGVFIK FRNTPIVKA 
TNRELSYLL LFSLLCCFS SSLFFIGEP QDWTCRLRQ PAFGISFVL 
CISCILVKT NRVLLVFEA KIPTSFHRK WWGLNLQFL LVFLCTFMQ 
IVICVIWLY TAPPSSYRN QELEDEIIF ITCHEGSLM ALGFLIGYT 
CLLAAICFF FAFKSRKLP ENFNEAKFI TFSMLIFFI VWISFIPAY 
ASTYGKFVS AVEVIAILA ASFGLLACI FFNKIYIIL FKPSRNTIE 
EVRCSTAAH AFKVAARAT LR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP41180
Sequence
>8SZG_nogp_Chain_S
YGPDQRAQK KGDIILGGL FPIHFGVAA KDQDLKSRP ESVECIRYN 
FRGFRWLQA MIFAIEEIN SSPALLPNL TLGYRIFDT CNTVSKALE 
ATLSFVAQN KIHIPSTIA VVGATGSGV STAVANLLG LFYIPQVSY 
ASSSRLLSN KNQFKSFLR TIPNDEHQA TAMADIIEY FRWNWVGTI 
AADDDYGRP GIEKFREEA EERDICIDF SELISQYSD EEEIQHVVE 
VIQNSTAKV IVVFSSGPD LEPLIKEIV RRNITGKIW LASEAWASS 
SLIAMPQYF HVVGGTIGF ALKAGQIPG FREFLKKVH PRKSVHNGF 
AKEFWEETF NCHLQERPL CTGDENISS VETPYIDYT HLRISYNVY 
LAVYSIAHA LQDIYTCLP GRGLFTNGS CADIKKVEA WQVLKHLRH 
LNFTNNMGE QVTFDECGD LVGNYSIIN WHLSPEDGS IVFKEVGYY 
NVYAKKGER LFINEEKIL WSGFSREVP FSNCSRDCL AGTRKGIIE 
GEPTCCFEC VECPDGEYS DETDASACN KCPDDFWSN ENHTSCIAK 
EIEFLSWTE PFGIALTLF AVLGIFLTA FVLGVFIKF RNTPIVKAT 
NRELSYLLL FSLLCCFSS SLFFIGEPQ DWTCRLRQP AFGISFVLC 
ISCILVKTN RVLLVFENL QFLLVFLCT FMQIVICVI WLYTAPPSS 
YRNQELEDE IIFITCHEG SLMALGFLI GYTCLLAAI CFFFAFKSR 
KLPENFNEA KFITFSMLI FFIVWISFI PAYASTYGK FVSAVEVIA 
ILAASFGLL ACIFFNKIY IILFKPSRN TIEE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WPGCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca-2.72023-11-22doi.org/10.1038/s41422-023-00892-2
8WPUCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(NtGi2L-Gs-CtGq)/β1/γ23.12023-11-22doi.org/10.1038/s41422-023-00892-2
8WPU (No Gprot) CIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca3.12023-11-22doi.org/10.1038/s41422-023-00892-2
7DTUCIonCalcium SensingCaSHomo sapiens-Tryptophan-4.42021-03-10doi.org/10.1038/s41422-021-00474-0
7M3JCIonCalcium SensingCaSHomo sapiens-NPS-2143; PO4-4.12021-06-30doi.org/10.1038/s41586-021-03691-0
7SINCIonCalcium SensingCaSHomo sapiens-NPS-2143-5.92022-01-19doi.org/10.1073/pnas.2115849118
9C1PCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan; '6218; PO4-2.82024-10-02doi.org/10.1126/science.ado1868
7DTVCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan-3.52021-03-10doi.org/10.1038/s41422-021-00474-0
7M3ECIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; NPS-2143-3.22021-06-30doi.org/10.1038/s41586-021-03691-0
7DD5CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; NPS-2143-3.22021-06-16doi.org/10.1126/sciadv.abg1483
7M3GCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4-2.52021-06-30doi.org/10.1038/s41586-021-03691-0
7DD7CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; Evocalcet-3.22021-06-16doi.org/10.1126/sciadv.abg1483
8SZFCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-2.82024-02-07doi.org/10.1038/s41586-024-07055-2
8SZGCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Sperminechim(NtGi1-Gq)/β1/γ23.62024-02-07doi.org/10.1038/s41586-024-07055-2
8SZG (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine3.62024-02-07doi.org/10.1038/s41586-024-07055-2
8SZHCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; SpermineGi1/β1/γ23.12024-02-07doi.org/10.1038/s41586-024-07055-2
8SZH (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine3.12024-02-07doi.org/10.1038/s41586-024-07055-2
7M3FCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4-2.82021-06-30doi.org/10.1038/s41586-021-03691-0
8SZICIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4Gi3/β1/γ23.52024-02-07doi.org/10.1038/s41586-024-07055-2
8SZI (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO43.52024-02-07doi.org/10.1038/s41586-024-07055-2
9C2FCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Tryptophan; '54149; PO4-2.82024-10-02doi.org/10.1126/science.ado1868
7DD6CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan-3.22021-06-16doi.org/10.1126/sciadv.abg1483
7SIMCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-2.72022-01-19doi.org/10.1073/pnas.2115849118
7E6TCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-32021-09-22doi.org/10.7554/eLife.68578
9ASBCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.42024-04-17doi.org/10.1038/s41586-024-07331-1
9ASB (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.42024-04-17doi.org/10.1038/s41586-024-07331-1
9AVGCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs)/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AVG (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AVLCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4Gi3/β2/γ23.82024-04-17doi.org/10.1038/s41586-024-07331-1
9AVL (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.82024-04-17doi.org/10.1038/s41586-024-07331-1
9AXFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.52024-04-17doi.org/10.1038/s41586-024-07331-1
9AXF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.52024-04-17doi.org/10.1038/s41586-024-07331-1
9AYFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4Gi1/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AYF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-17doi.org/10.1038/s41586-024-07331-1
7SILCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-2.72022-01-19doi.org/10.1073/pnas.2115849118
7DTTCIonCalcium SensingCaSHomo sapiensCaCa-3.82021-03-10doi.org/10.1038/s41422-021-00474-0
7DTWCIonCalcium SensingCaSHomo sapiens---4.52021-03-10doi.org/10.1038/s41422-021-00474-0
7E6UCIonCalcium SensingCaSHomo sapiens---62021-09-22doi.org/10.7554/eLife.68578




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