Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7M3F | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Cinacalcet; PO4 | - | 2.8 | 2021-06-30 | 10.1038/s41586-021-03691-0 |
![](/psngpcr/ligands/YP4/YP4_7M3F_W_W_905.png)
A 2D representation of the interactions of YP4 in 7M3F colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:C661 | R:R:F684 | 2.79 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:F684 | R:R:S664 | 5.28 | 0 | Yes | No | 8 | 6 | 1 | 2 | R:R:E837 | R:R:F668 | 7 | 14 | No | Yes | 9 | 9 | 1 | 2 | R:R:F668 | R:R:I841 | 3.77 | 0 | Yes | No | 9 | 9 | 2 | 2 | R:R:Q681 | R:R:W742 | 6.57 | 14 | Yes | Yes | 9 | 9 | 1 | 2 | R:R:E767 | R:R:Q681 | 10.19 | 14 | No | Yes | 7 | 9 | 2 | 1 | R:R:L773 | R:R:Q681 | 5.32 | 14 | Yes | Yes | 8 | 9 | 2 | 1 | R:R:Q681 | W:W:?905 | 6.95 | 14 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:F684 | R:R:F688 | 3.22 | 0 | Yes | Yes | 8 | 8 | 1 | 2 | R:R:F684 | R:R:I841 | 6.28 | 0 | Yes | No | 8 | 9 | 1 | 2 | R:R:F684 | W:W:?905 | 18.16 | 0 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:F688 | R:R:F814 | 10.72 | 0 | Yes | Yes | 8 | 9 | 2 | 2 | R:R:Q735 | R:R:T780 | 5.67 | 0 | Yes | No | 9 | 7 | 2 | 1 | R:R:E767 | R:R:L773 | 2.65 | 14 | No | Yes | 7 | 8 | 2 | 2 | R:R:I777 | R:R:L773 | 7.14 | 0 | Yes | Yes | 8 | 8 | 1 | 2 | R:R:I777 | W:W:?905 | 15.96 | 0 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:T780 | W:W:?905 | 5.49 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:F814 | R:R:W818 | 7.02 | 0 | Yes | No | 9 | 9 | 2 | 1 | R:R:A840 | R:R:W818 | 7.78 | 0 | No | No | 9 | 9 | 2 | 1 | R:R:W818 | W:W:?905 | 31.42 | 0 | No | Yes | 9 | 0 | 1 | 0 | R:R:I819 | R:R:I822 | 2.94 | 0 | No | No | 6 | 7 | 2 | 1 | R:R:I822 | R:R:P823 | 3.39 | 0 | No | No | 7 | 9 | 1 | 2 | R:R:I822 | W:W:?905 | 4.26 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:Y825 | R:R:Y829 | 4.96 | 14 | Yes | No | 9 | 6 | 1 | 2 | R:R:V833 | R:R:Y825 | 5.05 | 0 | No | Yes | 6 | 9 | 2 | 1 | R:R:E837 | R:R:Y825 | 7.86 | 14 | No | Yes | 9 | 9 | 1 | 1 | R:R:Y825 | W:W:?905 | 13.11 | 14 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:E837 | W:W:?905 | 3.95 | 14 | No | Yes | 9 | 0 | 1 | 0 | R:R:G685 | W:W:?905 | 2.55 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:G778 | R:R:I777 | 1.76 | 0 | No | Yes | 5 | 8 | 2 | 1 | R:R:C781 | R:R:I777 | 1.64 | 0 | No | Yes | 7 | 8 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 11.32 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 11.00 | Average Links In Shell | 31.00 | Average Links Mediated by Hubs In Shell | 28.00 |
| ![](/psngpcr/ligands/YP4/YP4_7M3F_W_W_905_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/YP4/YP4_7M3F_W_W_905_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/YP4/YP4_7M3F_X_X_906.png)
A 2D representation of the interactions of YP4 in 7M3F colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:C661 | S:S:F684 | 2.79 | 11 | Yes | Yes | 7 | 8 | 2 | 1 | S:S:C661 | S:S:F688 | 2.79 | 11 | Yes | Yes | 7 | 8 | 2 | 2 | S:S:F684 | S:S:S664 | 2.64 | 11 | Yes | No | 8 | 6 | 1 | 2 | S:S:Q681 | X:X:?906 | 9.92 | 0 | No | Yes | 9 | 0 | 1 | 0 | S:S:F684 | S:S:F688 | 4.29 | 11 | Yes | Yes | 8 | 8 | 1 | 2 | S:S:F684 | S:S:I841 | 10.05 | 11 | Yes | No | 8 | 9 | 1 | 2 | S:S:F684 | X:X:?906 | 16.34 | 11 | Yes | Yes | 8 | 0 | 1 | 0 | S:S:F688 | S:S:F814 | 9.65 | 11 | Yes | Yes | 8 | 9 | 2 | 2 | S:S:Q735 | S:S:V689 | 7.16 | 0 | Yes | No | 9 | 7 | 2 | 2 | S:S:T780 | S:S:V689 | 4.76 | 0 | No | No | 7 | 7 | 1 | 2 | S:S:L776 | S:S:Q735 | 5.32 | 0 | Yes | Yes | 8 | 9 | 1 | 2 | S:S:E767 | S:S:L770 | 2.65 | 0 | No | No | 7 | 3 | 2 | 1 | S:S:L770 | X:X:?906 | 8.25 | 0 | No | Yes | 3 | 0 | 1 | 0 | S:S:I777 | S:S:L773 | 4.28 | 11 | No | No | 8 | 8 | 1 | 1 | S:S:L773 | X:X:?906 | 14.45 | 11 | No | Yes | 8 | 0 | 1 | 0 | S:S:L776 | X:X:?906 | 3.1 | 0 | Yes | Yes | 8 | 0 | 1 | 0 | S:S:I777 | X:X:?906 | 8.51 | 11 | No | Yes | 8 | 0 | 1 | 0 | S:S:T780 | X:X:?906 | 5.49 | 0 | No | Yes | 7 | 0 | 1 | 0 | S:S:F814 | S:S:W818 | 6.01 | 11 | Yes | Yes | 9 | 9 | 2 | 1 | S:S:W818 | S:S:Y825 | 4.82 | 0 | Yes | No | 9 | 9 | 1 | 2 | S:S:A840 | S:S:W818 | 6.48 | 0 | No | Yes | 9 | 9 | 2 | 1 | S:S:W818 | X:X:?906 | 17.83 | 0 | Yes | Yes | 9 | 0 | 1 | 0 | S:S:G685 | X:X:?906 | 2.55 | 0 | No | Yes | 8 | 0 | 1 | 0 | S:S:L773 | S:S:W742 | 2.28 | 11 | No | Yes | 8 | 9 | 1 | 2 | S:S:L776 | S:S:W742 | 2.28 | 0 | Yes | Yes | 8 | 9 | 1 | 2 | S:S:C781 | S:S:I777 | 1.64 | 0 | No | No | 7 | 8 | 2 | 1 | S:S:C739 | S:S:L776 | 1.59 | 0 | No | Yes | 7 | 8 | 2 | 1 | S:S:A844 | S:S:W818 | 1.3 | 0 | No | Yes | 9 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 9.60 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 9.00 | Average Links In Shell | 28.00 | Average Links Mediated by Hubs In Shell | 24.00 |
| ![](/psngpcr/ligands/YP4/YP4_7M3F_X_X_906_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/YP4/YP4_7M3F_X_X_906_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8SZF | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW | - | 2.8 | 2024-02-07 | 10.1038/s41586-024-07055-2 |
![](/psngpcr/ligands/YP4/YP4_8SZF_W_W_6.png)
A 2D representation of the interactions of YP4 in 8SZF colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:F684 | R:R:S664 | 3.96 | 20 | Yes | No | 8 | 6 | 1 | 2 | R:R:L773 | R:R:Q681 | 3.99 | 0 | No | No | 8 | 9 | 2 | 1 | R:R:Q681 | W:W:?6 | 12.9 | 0 | No | Yes | 9 | 0 | 1 | 0 | R:R:F684 | R:R:G685 | 3.01 | 20 | Yes | No | 8 | 8 | 1 | 1 | R:R:F684 | R:R:F688 | 6.43 | 20 | Yes | Yes | 8 | 8 | 1 | 2 | R:R:F684 | R:R:I841 | 12.56 | 20 | Yes | No | 8 | 9 | 1 | 2 | R:R:F684 | W:W:?6 | 16.34 | 20 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:G685 | R:R:Q735 | 4.93 | 20 | No | Yes | 8 | 9 | 1 | 2 | R:R:G685 | W:W:?6 | 2.55 | 20 | No | Yes | 8 | 0 | 1 | 0 | R:R:F688 | R:R:F814 | 10.72 | 0 | Yes | Yes | 8 | 9 | 2 | 2 | R:R:Q735 | R:R:V689 | 8.6 | 20 | Yes | No | 9 | 7 | 2 | 2 | R:R:T780 | R:R:V689 | 4.76 | 20 | No | No | 7 | 7 | 1 | 2 | R:R:Q735 | R:R:T780 | 4.25 | 20 | Yes | No | 9 | 7 | 2 | 1 | R:R:I777 | W:W:?6 | 14.9 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:T780 | W:W:?6 | 6.59 | 20 | No | Yes | 7 | 0 | 1 | 0 | R:R:F814 | R:R:W818 | 9.02 | 51 | Yes | No | 9 | 9 | 2 | 1 | R:R:A840 | R:R:W818 | 6.48 | 0 | No | No | 9 | 9 | 2 | 1 | R:R:W818 | W:W:?6 | 24.62 | 0 | No | Yes | 9 | 0 | 1 | 0 | R:R:I822 | R:R:P823 | 3.39 | 0 | No | No | 7 | 9 | 1 | 2 | R:R:I822 | W:W:?6 | 4.26 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:V833 | R:R:Y825 | 2.52 | 0 | No | No | 6 | 9 | 2 | 1 | R:R:E837 | R:R:Y825 | 3.37 | 0 | No | No | 9 | 9 | 2 | 1 | R:R:Y825 | W:W:?6 | 18.35 | 0 | No | Yes | 9 | 0 | 1 | 0 | R:R:G778 | R:R:I777 | 1.76 | 0 | No | No | 5 | 8 | 2 | 1 | R:R:I819 | R:R:I822 | 1.47 | 0 | No | No | 6 | 7 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 12.56 | Average Nodes In Shell | 22.00 | Average Hubs In Shell | 5.00 | Average Links In Shell | 25.00 | Average Links Mediated by Hubs In Shell | 17.00 |
| ![](/psngpcr/ligands/YP4/YP4_8SZF_W_W_6_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/YP4/YP4_8SZF_W_W_6_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/YP4/YP4_8SZF_K_K_4.png)
A 2D representation of the interactions of YP4 in 8SZF colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:Q681 | S:S:R680 | 3.5 | 9 | Yes | No | 9 | 8 | 1 | 2 | S:S:E767 | S:S:Q681 | 3.82 | 9 | No | Yes | 7 | 9 | 2 | 1 | S:S:L773 | S:S:Q681 | 5.32 | 9 | Yes | Yes | 8 | 9 | 1 | 1 | S:S:E837 | S:S:Q681 | 2.55 | 0 | No | Yes | 9 | 9 | 2 | 1 | K:K:?4 | S:S:Q681 | 10.91 | 9 | Yes | Yes | 0 | 9 | 0 | 1 | S:S:F684 | S:S:G685 | 3.01 | 9 | Yes | No | 8 | 8 | 1 | 1 | S:S:F684 | S:S:F688 | 6.43 | 9 | Yes | Yes | 8 | 8 | 1 | 2 | S:S:F684 | S:S:I841 | 13.82 | 9 | Yes | No | 8 | 9 | 1 | 2 | K:K:?4 | S:S:F684 | 15.44 | 9 | Yes | Yes | 0 | 8 | 0 | 1 | K:K:?4 | S:S:G685 | 2.55 | 9 | Yes | No | 0 | 8 | 0 | 1 | S:S:F688 | S:S:T780 | 2.59 | 0 | Yes | No | 8 | 7 | 2 | 1 | S:S:F688 | S:S:F814 | 8.57 | 0 | Yes | Yes | 8 | 9 | 2 | 2 | S:S:E767 | S:S:L773 | 3.98 | 9 | No | Yes | 7 | 8 | 2 | 1 | K:K:?4 | S:S:L770 | 10.32 | 9 | Yes | No | 0 | 3 | 0 | 1 | K:K:?4 | S:S:L773 | 11.35 | 9 | Yes | Yes | 0 | 8 | 0 | 1 | K:K:?4 | S:S:I777 | 9.58 | 9 | Yes | No | 0 | 8 | 0 | 1 | K:K:?4 | S:S:T780 | 6.59 | 9 | Yes | No | 0 | 7 | 0 | 1 | S:S:F814 | S:S:W818 | 10.02 | 9 | Yes | Yes | 9 | 9 | 2 | 1 | S:S:W818 | S:S:Y825 | 5.79 | 9 | Yes | Yes | 9 | 9 | 1 | 1 | S:S:A840 | S:S:W818 | 7.78 | 0 | No | Yes | 9 | 9 | 2 | 1 | K:K:?4 | S:S:W818 | 15.28 | 9 | Yes | Yes | 0 | 9 | 0 | 1 | S:S:V836 | S:S:Y825 | 3.79 | 0 | No | Yes | 8 | 9 | 2 | 1 | S:S:E837 | S:S:Y825 | 11.22 | 0 | No | Yes | 9 | 9 | 2 | 1 | K:K:?4 | S:S:Y825 | 5.24 | 9 | Yes | Yes | 0 | 9 | 0 | 1 | S:S:L773 | S:S:W742 | 2.28 | 9 | Yes | Yes | 8 | 9 | 1 | 2 | S:S:G774 | S:S:L773 | 1.71 | 0 | No | Yes | 4 | 8 | 2 | 1 | S:S:F684 | S:S:S664 | 1.32 | 9 | Yes | No | 8 | 6 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 9.70 | Average Nodes In Shell | 21.00 | Average Hubs In Shell | 9.00 | Average Links In Shell | 27.00 | Average Links Mediated by Hubs In Shell | 27.00 |
| ![](/psngpcr/ligands/YP4/YP4_8SZF_K_K_4_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/YP4/YP4_8SZF_K_K_4_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8SZG | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW | chim(NtGi1-Gq)/Beta1/Gamma2 | 3.6 | 2024-02-07 | 10.1038/s41586-024-07055-2 |
![](/psngpcr/ligands/YP4/YP4_8SZG_W_W_1.png)
A 2D representation of the interactions of YP4 in 8SZG colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:F684 | R:R:S664 | 5.28 | 4 | Yes | No | 8 | 6 | 1 | 2 | R:R:F668 | R:R:R680 | 9.62 | 0 | Yes | Yes | 9 | 8 | 2 | 2 | R:R:E837 | R:R:F668 | 2.33 | 0 | No | Yes | 9 | 9 | 1 | 2 | R:R:F668 | R:R:I841 | 2.51 | 0 | Yes | No | 9 | 9 | 2 | 2 | R:R:Q681 | R:R:R680 | 2.34 | 4 | Yes | Yes | 9 | 8 | 1 | 2 | R:R:E767 | R:R:Q681 | 6.37 | 4 | Yes | Yes | 7 | 9 | 2 | 1 | R:R:L773 | R:R:Q681 | 10.65 | 4 | Yes | Yes | 8 | 9 | 2 | 1 | R:R:Q681 | W:W:?1 | 6.95 | 4 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:F684 | R:R:G685 | 3.01 | 4 | Yes | No | 8 | 8 | 1 | 1 | R:R:F684 | R:R:F688 | 6.43 | 4 | Yes | Yes | 8 | 8 | 1 | 2 | R:R:F684 | R:R:I841 | 7.54 | 4 | Yes | No | 8 | 9 | 1 | 2 | R:R:F684 | W:W:?1 | 14.53 | 4 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:G685 | W:W:?1 | 2.55 | 4 | No | Yes | 8 | 0 | 1 | 0 | R:R:F688 | R:R:F814 | 10.72 | 4 | Yes | Yes | 8 | 9 | 2 | 1 | R:R:Q735 | R:R:V689 | 12.89 | 4 | Yes | No | 9 | 7 | 2 | 2 | R:R:T780 | R:R:V689 | 4.76 | 4 | No | No | 7 | 7 | 1 | 2 | R:R:Q735 | R:R:T780 | 5.67 | 4 | Yes | No | 9 | 7 | 2 | 1 | R:R:E767 | R:R:L773 | 6.63 | 4 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:G778 | R:R:I777 | 1.76 | 0 | No | No | 5 | 8 | 2 | 1 | R:R:I777 | W:W:?1 | 13.83 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:T780 | W:W:?1 | 5.49 | 4 | No | Yes | 7 | 0 | 1 | 0 | R:R:F814 | R:R:M811 | 3.73 | 4 | Yes | Yes | 9 | 9 | 1 | 2 | R:R:F814 | R:R:F815 | 6.43 | 4 | Yes | Yes | 9 | 7 | 1 | 2 | R:R:F814 | R:R:W818 | 8.02 | 4 | Yes | Yes | 9 | 9 | 1 | 1 | R:R:F814 | W:W:?1 | 4.54 | 4 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:V817 | R:R:W818 | 2.45 | 4 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:A840 | R:R:V817 | 1.7 | 4 | No | Yes | 9 | 9 | 2 | 2 | R:R:A840 | R:R:W818 | 9.08 | 4 | No | Yes | 9 | 9 | 2 | 1 | R:R:I841 | R:R:W818 | 2.35 | 0 | No | Yes | 9 | 9 | 2 | 1 | R:R:W818 | W:W:?1 | 26.32 | 4 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:V833 | R:R:Y825 | 2.52 | 0 | No | No | 6 | 9 | 2 | 1 | R:R:Y825 | W:W:?1 | 15.73 | 0 | No | Yes | 9 | 0 | 1 | 0 | R:R:E837 | R:R:V833 | 2.85 | 0 | No | No | 9 | 6 | 1 | 2 | R:R:E837 | W:W:?1 | 4.94 | 0 | No | Yes | 9 | 0 | 1 | 0 | R:R:C781 | R:R:I777 | 1.64 | 0 | No | No | 7 | 8 | 2 | 1 | R:R:A844 | R:R:F688 | 1.39 | 4 | No | Yes | 9 | 8 | 2 | 2 | R:R:A844 | R:R:F814 | 1.39 | 4 | No | Yes | 9 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 10.54 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 14.00 | Average Links In Shell | 37.00 | Average Links Mediated by Hubs In Shell | 32.00 |
| ![](/psngpcr/ligands/YP4/YP4_8SZG_W_W_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/YP4/YP4_8SZG_W_W_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/YP4/YP4_8SZG_K_K_3.png)
A 2D representation of the interactions of YP4 in 8SZG colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:F668 | S:S:R680 | 10.69 | 9 | Yes | Yes | 9 | 8 | 2 | 2 | S:S:F668 | S:S:Q681 | 2.34 | 9 | Yes | Yes | 9 | 9 | 2 | 1 | S:S:E837 | S:S:F668 | 10.49 | 9 | No | Yes | 9 | 9 | 1 | 2 | S:S:Q681 | S:S:R680 | 2.34 | 9 | Yes | Yes | 9 | 8 | 1 | 2 | S:S:P682 | S:S:Q681 | 4.74 | 0 | No | Yes | 5 | 9 | 2 | 1 | S:S:E767 | S:S:Q681 | 8.92 | 0 | No | Yes | 7 | 9 | 2 | 1 | S:S:L773 | S:S:Q681 | 3.99 | 9 | Yes | Yes | 8 | 9 | 1 | 1 | K:K:?3 | S:S:Q681 | 16.87 | 9 | Yes | Yes | 0 | 9 | 0 | 1 | S:S:P682 | S:S:W742 | 4.05 | 0 | No | Yes | 5 | 9 | 2 | 2 | S:S:F684 | S:S:G685 | 3.01 | 9 | Yes | No | 8 | 8 | 1 | 1 | S:S:F684 | S:S:F688 | 6.43 | 9 | Yes | Yes | 8 | 8 | 1 | 2 | S:S:F684 | S:S:W818 | 2 | 9 | Yes | Yes | 8 | 9 | 1 | 1 | S:S:F684 | S:S:I841 | 11.3 | 9 | Yes | No | 8 | 9 | 1 | 2 | K:K:?3 | S:S:F684 | 15.44 | 9 | Yes | Yes | 0 | 8 | 0 | 1 | K:K:?3 | S:S:G685 | 2.55 | 9 | Yes | No | 0 | 8 | 0 | 1 | S:S:F688 | S:S:F814 | 8.57 | 0 | Yes | Yes | 8 | 9 | 2 | 2 | S:S:L776 | S:S:Q735 | 5.32 | 0 | No | Yes | 8 | 9 | 1 | 2 | S:S:E767 | S:S:W742 | 2.18 | 0 | No | Yes | 7 | 9 | 2 | 2 | S:S:L773 | S:S:W742 | 2.28 | 9 | Yes | Yes | 8 | 9 | 1 | 2 | K:K:?3 | S:S:L770 | 3.1 | 9 | Yes | No | 0 | 3 | 0 | 1 | S:S:G774 | S:S:L773 | 1.71 | 0 | No | Yes | 4 | 8 | 2 | 1 | K:K:?3 | S:S:L773 | 6.19 | 9 | Yes | Yes | 0 | 8 | 0 | 1 | K:K:?3 | S:S:L776 | 4.13 | 9 | Yes | No | 0 | 8 | 0 | 1 | S:S:G778 | S:S:I777 | 1.76 | 0 | No | No | 5 | 8 | 2 | 1 | K:K:?3 | S:S:I777 | 11.7 | 9 | Yes | No | 0 | 8 | 0 | 1 | K:K:?3 | S:S:T780 | 7.69 | 9 | Yes | No | 0 | 7 | 0 | 1 | S:S:F814 | S:S:W818 | 8.02 | 0 | Yes | Yes | 9 | 9 | 2 | 1 | S:S:V817 | S:S:W818 | 3.68 | 9 | Yes | Yes | 9 | 9 | 2 | 1 | S:S:A840 | S:S:V817 | 1.7 | 9 | No | Yes | 9 | 9 | 2 | 2 | S:S:F821 | S:S:W818 | 8.02 | 9 | Yes | Yes | 9 | 9 | 1 | 1 | S:S:A840 | S:S:W818 | 7.78 | 9 | No | Yes | 9 | 9 | 2 | 1 | S:S:I841 | S:S:W818 | 2.35 | 9 | No | Yes | 9 | 9 | 2 | 1 | K:K:?3 | S:S:W818 | 13.59 | 9 | Yes | Yes | 0 | 9 | 0 | 1 | S:S:F821 | S:S:Y825 | 13.41 | 9 | Yes | No | 9 | 9 | 1 | 1 | S:S:F821 | S:S:V836 | 2.62 | 9 | Yes | No | 9 | 8 | 1 | 2 | S:S:E837 | S:S:F821 | 2.33 | 9 | No | Yes | 9 | 9 | 1 | 1 | K:K:?3 | S:S:F821 | 3.63 | 9 | Yes | Yes | 0 | 9 | 0 | 1 | S:S:V833 | S:S:Y825 | 6.31 | 0 | No | No | 6 | 9 | 2 | 1 | K:K:?3 | S:S:Y825 | 5.24 | 9 | Yes | No | 0 | 9 | 0 | 1 | K:K:?3 | S:S:E837 | 5.93 | 9 | Yes | No | 0 | 9 | 0 | 1 | S:S:A844 | S:S:W818 | 1.3 | 0 | No | Yes | 9 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 8.01 | Average Nodes In Shell | 29.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 41.00 | Average Links Mediated by Hubs In Shell | 39.00 |
| ![](/psngpcr/ligands/YP4/YP4_8SZG_K_K_3_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/YP4/YP4_8SZG_K_K_3_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8SZH | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW | Gi1/Beta1/Gamma2 | 3.1 | 2024-02-07 | 10.1038/s41586-024-07055-2 |
![](/psngpcr/ligands/YP4/YP4_8SZH_W_W_1.png)
A 2D representation of the interactions of YP4 in 8SZH colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:C661 | R:R:F684 | 2.79 | 0 | Yes | Yes | 7 | 8 | 2 | 1 | R:R:F684 | R:R:S664 | 3.96 | 3 | Yes | No | 8 | 6 | 1 | 2 | R:R:I841 | R:R:S664 | 1.55 | 3 | Yes | No | 9 | 6 | 2 | 2 | R:R:E837 | R:R:F668 | 10.49 | 0 | No | Yes | 9 | 9 | 1 | 2 | R:R:F668 | R:R:I841 | 3.77 | 0 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:P682 | R:R:Q681 | 1.58 | 0 | No | Yes | 5 | 9 | 2 | 1 | R:R:Q681 | R:R:W742 | 4.38 | 3 | Yes | Yes | 9 | 9 | 1 | 2 | R:R:E767 | R:R:Q681 | 10.19 | 3 | No | Yes | 7 | 9 | 2 | 1 | R:R:L773 | R:R:Q681 | 14.64 | 0 | No | Yes | 8 | 9 | 2 | 1 | R:R:Q681 | W:W:?1 | 6.95 | 3 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:C739 | R:R:P682 | 5.65 | 0 | No | No | 7 | 5 | 2 | 2 | R:R:F684 | R:R:G685 | 3.01 | 3 | Yes | No | 8 | 8 | 1 | 1 | R:R:F684 | R:R:F688 | 3.22 | 3 | Yes | Yes | 8 | 8 | 1 | 2 | R:R:F684 | R:R:I841 | 15.07 | 3 | Yes | Yes | 8 | 9 | 1 | 2 | R:R:F684 | W:W:?1 | 12.71 | 3 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:G685 | R:R:Q735 | 1.64 | 3 | No | Yes | 8 | 9 | 1 | 2 | R:R:G685 | W:W:?1 | 2.55 | 3 | No | Yes | 8 | 0 | 1 | 0 | R:R:F688 | R:R:I692 | 6.28 | 3 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:F688 | R:R:T780 | 2.59 | 3 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F688 | R:R:F814 | 9.65 | 3 | Yes | Yes | 8 | 9 | 2 | 1 | R:R:Q735 | R:R:V689 | 8.6 | 3 | Yes | Yes | 9 | 7 | 2 | 2 | R:R:T780 | R:R:V689 | 3.17 | 3 | Yes | Yes | 7 | 7 | 1 | 2 | R:R:I692 | R:R:T780 | 1.52 | 3 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:L776 | R:R:Q735 | 7.99 | 0 | Yes | Yes | 8 | 9 | 1 | 2 | R:R:I738 | R:R:L776 | 2.85 | 0 | No | Yes | 8 | 8 | 2 | 1 | R:R:C739 | R:R:L776 | 3.17 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:E767 | R:R:W742 | 2.18 | 3 | No | Yes | 7 | 9 | 2 | 2 | R:R:I777 | R:R:L773 | 4.28 | 0 | Yes | No | 8 | 8 | 1 | 2 | R:R:G774 | R:R:I777 | 3.53 | 0 | No | Yes | 4 | 8 | 2 | 1 | R:R:L776 | W:W:?1 | 2.06 | 0 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:G778 | R:R:I777 | 1.76 | 0 | No | Yes | 5 | 8 | 2 | 1 | R:R:C781 | R:R:I777 | 1.64 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:I777 | W:W:?1 | 8.51 | 0 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:T780 | W:W:?1 | 6.59 | 3 | Yes | Yes | 7 | 0 | 1 | 0 | R:R:F814 | R:R:F815 | 6.43 | 3 | Yes | Yes | 9 | 7 | 1 | 2 | R:R:F814 | R:R:W818 | 8.02 | 3 | Yes | Yes | 9 | 9 | 1 | 1 | R:R:F814 | W:W:?1 | 3.63 | 3 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:A840 | R:R:W818 | 9.08 | 3 | No | Yes | 9 | 9 | 2 | 1 | R:R:I841 | R:R:W818 | 2.35 | 3 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:W818 | W:W:?1 | 24.62 | 3 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:I822 | R:R:P823 | 3.39 | 0 | No | Yes | 7 | 9 | 1 | 2 | R:R:I822 | W:W:?1 | 4.26 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:V833 | R:R:Y825 | 2.52 | 0 | No | No | 6 | 9 | 2 | 1 | R:R:Y825 | W:W:?1 | 16.6 | 0 | No | Yes | 9 | 0 | 1 | 0 | R:R:E837 | W:W:?1 | 6.91 | 0 | No | Yes | 9 | 0 | 1 | 0 | R:R:A844 | R:R:F814 | 1.39 | 0 | No | Yes | 9 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 8.67 | Average Nodes In Shell | 34.00 | Average Hubs In Shell | 18.00 | Average Links In Shell | 46.00 | Average Links Mediated by Hubs In Shell | 44.00 |
| ![](/psngpcr/ligands/YP4/YP4_8SZH_W_W_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/YP4/YP4_8SZH_W_W_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/YP4/YP4_8SZH_K_K_1.png)
A 2D representation of the interactions of YP4 in 8SZH colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | K:K:?2 | R:R:F612 | 3.2 | 3 | Yes | No | 0 | 8 | 1 | 2 | K:K:?2 | R:R:F832 | 4.79 | 3 | Yes | No | 0 | 5 | 1 | 2 | S:S:C661 | S:S:F684 | 2.79 | 3 | Yes | Yes | 7 | 8 | 2 | 1 | S:S:C661 | S:S:I841 | 1.64 | 3 | Yes | Yes | 7 | 9 | 2 | 2 | S:S:F684 | S:S:S664 | 5.28 | 3 | Yes | No | 8 | 6 | 1 | 2 | S:S:F668 | S:S:R680 | 9.62 | 3 | Yes | Yes | 9 | 8 | 2 | 2 | S:S:E837 | S:S:F668 | 7 | 3 | Yes | Yes | 9 | 9 | 1 | 2 | S:S:F668 | S:S:I841 | 2.51 | 3 | Yes | Yes | 9 | 9 | 2 | 2 | S:S:Q681 | S:S:R680 | 4.67 | 3 | Yes | Yes | 9 | 8 | 1 | 2 | S:S:P682 | S:S:Q681 | 3.16 | 3 | Yes | Yes | 5 | 9 | 2 | 1 | S:S:Q681 | S:S:W742 | 3.29 | 3 | Yes | Yes | 9 | 9 | 1 | 2 | S:S:L773 | S:S:Q681 | 3.99 | 3 | Yes | Yes | 8 | 9 | 1 | 1 | K:K:?1 | S:S:Q681 | 11.91 | 3 | Yes | Yes | 0 | 9 | 0 | 1 | S:S:P682 | S:S:W742 | 4.05 | 3 | Yes | Yes | 5 | 9 | 2 | 2 | S:S:F684 | S:S:G685 | 3.01 | 3 | Yes | No | 8 | 8 | 1 | 1 | S:S:F684 | S:S:F688 | 7.5 | 3 | Yes | Yes | 8 | 8 | 1 | 2 | S:S:F684 | S:S:W818 | 3.01 | 3 | Yes | Yes | 8 | 9 | 1 | 1 | S:S:F684 | S:S:I841 | 13.82 | 3 | Yes | Yes | 8 | 9 | 1 | 2 | K:K:?1 | S:S:F684 | 11.8 | 3 | Yes | Yes | 0 | 8 | 0 | 1 | S:S:G685 | S:S:Q735 | 1.64 | 3 | No | Yes | 8 | 9 | 1 | 2 | K:K:?1 | S:S:G685 | 2.55 | 3 | Yes | No | 0 | 8 | 0 | 1 | S:S:F688 | S:S:F814 | 7.5 | 0 | Yes | Yes | 8 | 9 | 2 | 2 | S:S:Q735 | S:S:V689 | 10.03 | 3 | Yes | No | 9 | 7 | 2 | 2 | S:S:T780 | S:S:V689 | 4.76 | 3 | No | No | 7 | 7 | 1 | 2 | S:S:Q735 | S:S:T780 | 4.25 | 3 | Yes | No | 9 | 7 | 2 | 1 | S:S:L773 | S:S:W742 | 2.28 | 3 | Yes | Yes | 8 | 9 | 1 | 2 | S:S:E767 | S:S:L773 | 3.98 | 3 | No | Yes | 7 | 8 | 1 | 1 | K:K:?1 | S:S:E767 | 7.9 | 3 | Yes | No | 0 | 7 | 0 | 1 | K:K:?1 | S:S:L770 | 4.13 | 3 | Yes | No | 0 | 3 | 0 | 1 | S:S:I777 | S:S:L773 | 2.85 | 3 | Yes | Yes | 8 | 8 | 1 | 1 | K:K:?1 | S:S:L773 | 6.19 | 3 | Yes | Yes | 0 | 8 | 0 | 1 | S:S:G774 | S:S:I777 | 1.76 | 0 | No | Yes | 4 | 8 | 2 | 1 | S:S:C781 | S:S:I777 | 1.64 | 3 | No | Yes | 7 | 8 | 2 | 1 | K:K:?1 | S:S:I777 | 7.45 | 3 | Yes | Yes | 0 | 8 | 0 | 1 | K:K:?2 | S:S:I777 | 3.75 | 3 | Yes | Yes | 0 | 8 | 1 | 1 | K:K:?1 | S:S:T780 | 6.59 | 3 | Yes | No | 0 | 7 | 0 | 1 | K:K:?2 | S:S:C781 | 2.08 | 3 | Yes | No | 0 | 7 | 1 | 2 | S:S:F814 | S:S:W818 | 12.03 | 0 | Yes | Yes | 9 | 9 | 2 | 1 | S:S:F821 | S:S:W818 | 9.02 | 3 | Yes | Yes | 9 | 9 | 1 | 1 | S:S:A840 | S:S:W818 | 7.78 | 3 | No | Yes | 9 | 9 | 2 | 1 | K:K:?1 | S:S:W818 | 12.74 | 3 | Yes | Yes | 0 | 9 | 0 | 1 | K:K:?2 | S:S:I819 | 5.62 | 3 | Yes | No | 0 | 6 | 1 | 2 | S:S:F821 | S:S:Y825 | 9.28 | 3 | Yes | Yes | 9 | 9 | 1 | 1 | S:S:F821 | S:S:V836 | 2.62 | 3 | Yes | No | 9 | 8 | 1 | 2 | S:S:E837 | S:S:F821 | 2.33 | 3 | Yes | Yes | 9 | 9 | 1 | 1 | S:S:A840 | S:S:F821 | 2.77 | 3 | No | Yes | 9 | 9 | 2 | 1 | K:K:?1 | S:S:F821 | 2.72 | 3 | Yes | Yes | 0 | 9 | 0 | 1 | K:K:?2 | S:S:F821 | 1.6 | 3 | Yes | Yes | 0 | 9 | 1 | 1 | S:S:I822 | S:S:P823 | 5.08 | 3 | No | No | 7 | 9 | 2 | 2 | K:K:?2 | S:S:I822 | 6.56 | 3 | Yes | No | 0 | 7 | 1 | 2 | K:K:?2 | S:S:P823 | 9.7 | 3 | Yes | No | 0 | 9 | 1 | 2 | S:S:V833 | S:S:Y825 | 5.05 | 3 | No | Yes | 6 | 9 | 2 | 1 | S:S:E837 | S:S:Y825 | 6.73 | 3 | Yes | Yes | 9 | 9 | 1 | 1 | K:K:?1 | S:S:Y825 | 10.49 | 3 | Yes | Yes | 0 | 9 | 0 | 1 | K:K:?2 | S:S:Y825 | 12.31 | 3 | Yes | Yes | 0 | 9 | 1 | 1 | K:K:?2 | S:S:A826 | 5.17 | 3 | Yes | No | 0 | 5 | 1 | 2 | K:K:?2 | S:S:Y829 | 13.84 | 3 | Yes | No | 0 | 6 | 1 | 2 | S:S:E837 | S:S:V833 | 2.85 | 3 | Yes | No | 9 | 6 | 1 | 2 | K:K:?2 | S:S:V833 | 1.95 | 3 | Yes | No | 0 | 6 | 1 | 2 | K:K:?1 | S:S:E837 | 5.93 | 3 | Yes | Yes | 0 | 9 | 0 | 1 | K:K:?1 | K:K:?2 | 6.77 | 3 | Yes | Yes | 0 | 0 | 0 | 1 | K:K:?2 | R:R:A843 | 1.03 | 3 | Yes | No | 0 | 7 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 9.00 | Average Interaction Strength | 7.47 | Average Nodes In Shell | 38.00 | Average Hubs In Shell | 19.00 | Average Links In Shell | 62.00 | Average Links Mediated by Hubs In Shell | 60.00 |
| ![](/psngpcr/ligands/YP4/YP4_8SZH_K_K_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/YP4/YP4_8SZH_K_K_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8WPG | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Tryptophan; Cinacalcet; PO4; Ca | - | 2.7 | 2023-11-22 | 10.1038/s41422-023-00892-2 |
![](/psngpcr/ligands/YP4/YP4_8WPG_X_X_6.png)
A 2D representation of the interactions of YP4 in 8WPG colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:F684 | S:S:S664 | 3.96 | 0 | Yes | No | 8 | 6 | 1 | 2 | S:S:F668 | S:S:R680 | 14.97 | 14 | Yes | Yes | 9 | 8 | 2 | 2 | S:S:F668 | S:S:Q681 | 8.2 | 14 | Yes | Yes | 9 | 9 | 2 | 1 | S:S:E837 | S:S:F668 | 9.33 | 14 | Yes | Yes | 9 | 9 | 1 | 2 | S:S:F668 | S:S:I841 | 3.77 | 14 | Yes | Yes | 9 | 9 | 2 | 2 | S:S:Q681 | S:S:R680 | 9.35 | 14 | Yes | Yes | 9 | 8 | 1 | 2 | S:S:E767 | S:S:R680 | 4.65 | 14 | No | Yes | 7 | 8 | 2 | 2 | S:S:E767 | S:S:Q681 | 11.47 | 14 | No | Yes | 7 | 9 | 2 | 1 | S:S:L773 | S:S:Q681 | 7.99 | 14 | No | Yes | 8 | 9 | 2 | 1 | S:S:E837 | S:S:Q681 | 3.82 | 14 | Yes | Yes | 9 | 9 | 1 | 1 | S:S:Q681 | X:X:?6 | 12.9 | 14 | Yes | Yes | 9 | 0 | 1 | 0 | S:S:F684 | S:S:F688 | 10.72 | 0 | Yes | Yes | 8 | 8 | 1 | 2 | S:S:F684 | S:S:I841 | 16.33 | 0 | Yes | Yes | 8 | 9 | 1 | 2 | S:S:F684 | X:X:?6 | 24.52 | 0 | Yes | Yes | 8 | 0 | 1 | 0 | S:S:F688 | S:S:F814 | 13.93 | 0 | Yes | Yes | 8 | 9 | 2 | 2 | S:S:T780 | S:S:V689 | 4.76 | 0 | No | No | 7 | 7 | 1 | 2 | S:S:E767 | S:S:L773 | 5.3 | 14 | No | No | 7 | 8 | 2 | 2 | S:S:G774 | S:S:I777 | 3.53 | 0 | No | No | 4 | 8 | 2 | 1 | S:S:L776 | X:X:?6 | 4.13 | 0 | No | Yes | 8 | 0 | 1 | 0 | S:S:I777 | X:X:?6 | 14.9 | 0 | No | Yes | 8 | 0 | 1 | 0 | S:S:T780 | X:X:?6 | 4.4 | 0 | No | Yes | 7 | 0 | 1 | 0 | S:S:F814 | S:S:W818 | 9.02 | 0 | Yes | Yes | 9 | 9 | 2 | 1 | S:S:A840 | S:S:W818 | 7.78 | 0 | No | Yes | 9 | 9 | 2 | 1 | S:S:I841 | S:S:W818 | 3.52 | 0 | Yes | Yes | 9 | 9 | 2 | 1 | S:S:W818 | X:X:?6 | 30.57 | 0 | Yes | Yes | 9 | 0 | 1 | 0 | S:S:I822 | S:S:P823 | 3.39 | 0 | No | No | 7 | 9 | 1 | 2 | S:S:I822 | X:X:?6 | 6.38 | 0 | No | Yes | 7 | 0 | 1 | 0 | S:S:V833 | S:S:Y825 | 3.79 | 0 | No | No | 6 | 9 | 2 | 1 | S:S:E837 | S:S:Y825 | 5.61 | 14 | Yes | No | 9 | 9 | 1 | 1 | S:S:Y825 | X:X:?6 | 22.72 | 14 | No | Yes | 9 | 0 | 1 | 0 | S:S:E837 | X:X:?6 | 9.88 | 14 | Yes | Yes | 9 | 0 | 1 | 0 | S:S:G685 | X:X:?6 | 2.55 | 0 | No | Yes | 8 | 0 | 1 | 0 | S:S:G778 | S:S:I777 | 1.76 | 0 | No | No | 5 | 8 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 13.30 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 10.00 | Average Links In Shell | 33.00 | Average Links Mediated by Hubs In Shell | 27.00 |
| ![](/psngpcr/ligands/YP4/YP4_8WPG_X_X_6_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/YP4/YP4_8WPG_X_X_6_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/YP4/YP4_8WPG_W_W_4.png)
A 2D representation of the interactions of YP4 in 8WPG colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E837 | R:R:F668 | 11.66 | 9 | No | Yes | 9 | 9 | 1 | 2 | R:R:F668 | R:R:I841 | 3.77 | 9 | Yes | No | 9 | 9 | 2 | 2 | R:R:F684 | R:R:F688 | 9.65 | 0 | Yes | No | 8 | 8 | 1 | 2 | R:R:F684 | R:R:I841 | 12.56 | 0 | Yes | No | 8 | 9 | 1 | 2 | R:R:F684 | W:W:?4 | 19.98 | 0 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:F688 | R:R:F814 | 15 | 0 | No | Yes | 8 | 9 | 2 | 1 | R:R:T780 | R:R:V689 | 4.76 | 0 | No | No | 7 | 7 | 1 | 2 | R:R:I777 | R:R:L773 | 4.28 | 0 | No | Yes | 8 | 8 | 1 | 2 | R:R:I777 | W:W:?4 | 11.7 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:T780 | W:W:?4 | 7.69 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:F814 | R:R:W818 | 8.02 | 9 | Yes | Yes | 9 | 9 | 1 | 1 | R:R:F814 | W:W:?4 | 4.54 | 9 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:V817 | R:R:W818 | 3.68 | 0 | No | Yes | 9 | 9 | 2 | 1 | R:R:A840 | R:R:W818 | 9.08 | 0 | No | Yes | 9 | 9 | 2 | 1 | R:R:I841 | R:R:W818 | 3.52 | 0 | No | Yes | 9 | 9 | 2 | 1 | R:R:W818 | W:W:?4 | 36.51 | 9 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:I822 | R:R:P823 | 5.08 | 0 | Yes | No | 7 | 9 | 1 | 2 | R:R:I822 | W:W:?4 | 6.38 | 0 | Yes | Yes | 7 | 0 | 1 | 0 | R:R:V833 | R:R:Y825 | 3.79 | 0 | No | No | 6 | 9 | 2 | 1 | R:R:E837 | R:R:Y825 | 4.49 | 9 | No | No | 9 | 9 | 1 | 1 | R:R:Y825 | W:W:?4 | 10.49 | 9 | No | Yes | 9 | 0 | 1 | 0 | R:R:E837 | W:W:?4 | 7.9 | 9 | No | Yes | 9 | 0 | 1 | 0 | R:R:A784 | R:R:F814 | 2.77 | 0 | No | Yes | 8 | 9 | 2 | 1 | R:R:A844 | R:R:W818 | 2.59 | 0 | No | Yes | 9 | 9 | 2 | 1 | R:R:G685 | W:W:?4 | 2.55 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:G774 | R:R:I777 | 1.76 | 0 | No | No | 4 | 8 | 2 | 1 | R:R:A826 | R:R:I822 | 1.62 | 0 | No | Yes | 5 | 7 | 2 | 1 | R:R:I819 | R:R:I822 | 1.47 | 0 | No | Yes | 6 | 7 | 2 | 1 | R:R:F684 | R:R:S664 | 1.32 | 0 | Yes | No | 8 | 6 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 11.97 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 7.00 | Average Links In Shell | 29.00 | Average Links Mediated by Hubs In Shell | 25.00 |
| ![](/psngpcr/ligands/YP4/YP4_8WPG_W_W_4_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/YP4/YP4_8WPG_W_W_4_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8WPU | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Tryptophan; Cinacalcet; PO4; Ca | chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 | 3.1 | 2023-11-22 | 10.1038/s41422-023-00892-2 |
![](/psngpcr/ligands/YP4/YP4_8WPU_X_X_4.png)
A 2D representation of the interactions of YP4 in 8WPU colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:C661 | S:S:F684 | 2.79 | 0 | No | Yes | 7 | 8 | 2 | 1 | S:S:F684 | S:S:S664 | 5.28 | 12 | Yes | No | 8 | 6 | 1 | 2 | S:S:F668 | S:S:R680 | 13.9 | 0 | Yes | Yes | 9 | 8 | 2 | 2 | S:S:E837 | S:S:F668 | 10.49 | 12 | Yes | Yes | 9 | 9 | 1 | 2 | S:S:F668 | S:S:I841 | 3.77 | 0 | Yes | Yes | 9 | 9 | 2 | 1 | S:S:Q681 | S:S:R680 | 7.01 | 0 | No | Yes | 9 | 8 | 1 | 2 | S:S:L773 | S:S:Q681 | 5.32 | 0 | No | No | 8 | 9 | 2 | 1 | S:S:Q681 | X:X:?4 | 7.94 | 0 | No | Yes | 9 | 0 | 1 | 0 | S:S:F684 | S:S:F688 | 10.72 | 12 | Yes | Yes | 8 | 8 | 1 | 2 | S:S:F684 | S:S:W818 | 6.01 | 12 | Yes | Yes | 8 | 9 | 1 | 1 | S:S:F684 | S:S:I841 | 15.07 | 12 | Yes | Yes | 8 | 9 | 1 | 1 | S:S:F684 | X:X:?4 | 19.98 | 12 | Yes | Yes | 8 | 0 | 1 | 0 | S:S:G685 | S:S:Q735 | 4.93 | 0 | No | Yes | 8 | 9 | 1 | 2 | S:S:G685 | X:X:?4 | 2.55 | 0 | No | Yes | 8 | 0 | 1 | 0 | S:S:F688 | S:S:F814 | 7.5 | 0 | Yes | Yes | 8 | 9 | 2 | 2 | S:S:A844 | S:S:F688 | 2.77 | 0 | No | Yes | 9 | 8 | 2 | 2 | S:S:Q735 | S:S:V689 | 17.19 | 46 | Yes | Yes | 9 | 7 | 2 | 2 | S:S:T780 | S:S:V689 | 3.17 | 0 | No | Yes | 7 | 7 | 1 | 2 | S:S:E767 | S:S:W742 | 3.27 | 12 | Yes | Yes | 7 | 9 | 1 | 2 | S:S:E767 | S:S:H766 | 2.46 | 12 | Yes | Yes | 7 | 6 | 1 | 2 | S:S:E767 | S:S:L770 | 7.95 | 12 | Yes | No | 7 | 3 | 1 | 1 | S:S:E767 | S:S:L773 | 2.65 | 12 | Yes | No | 7 | 8 | 1 | 2 | S:S:E767 | X:X:?4 | 1.98 | 12 | Yes | Yes | 7 | 0 | 1 | 0 | S:S:L770 | X:X:?4 | 6.19 | 12 | No | Yes | 3 | 0 | 1 | 0 | S:S:I777 | X:X:?4 | 19.15 | 0 | No | Yes | 8 | 0 | 1 | 0 | S:S:T780 | X:X:?4 | 6.59 | 0 | No | Yes | 7 | 0 | 1 | 0 | S:S:F814 | S:S:W818 | 7.02 | 12 | Yes | Yes | 9 | 9 | 2 | 1 | S:S:F821 | S:S:W818 | 12.03 | 12 | Yes | Yes | 9 | 9 | 1 | 1 | S:S:A840 | S:S:W818 | 7.78 | 12 | No | Yes | 9 | 9 | 2 | 1 | S:S:I841 | S:S:W818 | 2.35 | 12 | Yes | Yes | 9 | 9 | 1 | 1 | S:S:A844 | S:S:W818 | 2.59 | 0 | No | Yes | 9 | 9 | 2 | 1 | S:S:W818 | X:X:?4 | 18.68 | 12 | Yes | Yes | 9 | 0 | 1 | 0 | S:S:F821 | S:S:Y825 | 11.35 | 12 | Yes | Yes | 9 | 9 | 1 | 1 | S:S:F821 | S:S:V836 | 3.93 | 12 | Yes | No | 9 | 8 | 1 | 2 | S:S:E837 | S:S:F821 | 2.33 | 12 | Yes | Yes | 9 | 9 | 1 | 1 | S:S:A840 | S:S:F821 | 4.16 | 12 | No | Yes | 9 | 9 | 2 | 1 | S:S:F821 | X:X:?4 | 1.82 | 12 | Yes | Yes | 9 | 0 | 1 | 0 | S:S:V833 | S:S:Y825 | 5.05 | 0 | No | Yes | 6 | 9 | 2 | 1 | S:S:V836 | S:S:Y825 | 2.52 | 12 | No | Yes | 8 | 9 | 2 | 1 | S:S:E837 | S:S:Y825 | 5.61 | 12 | Yes | Yes | 9 | 9 | 1 | 1 | S:S:Y825 | X:X:?4 | 10.49 | 12 | Yes | Yes | 9 | 0 | 1 | 0 | S:S:E837 | X:X:?4 | 6.91 | 12 | Yes | Yes | 9 | 0 | 1 | 0 | S:S:I841 | X:X:?4 | 2.13 | 12 | Yes | Yes | 9 | 0 | 1 | 0 | S:S:C781 | S:S:I777 | 1.64 | 0 | No | No | 7 | 8 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 8.70 | Average Nodes In Shell | 29.00 | Average Hubs In Shell | 16.00 | Average Links In Shell | 44.00 | Average Links Mediated by Hubs In Shell | 42.00 |
| ![](/psngpcr/ligands/YP4/YP4_8WPU_X_X_4_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/YP4/YP4_8WPU_X_X_4_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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![](/psngpcr/ligands/YP4/YP4_8WPU_W_W_4.png)
A 2D representation of the interactions of YP4 in 8WPU colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I822 | S:S:F612 | 2.51 | 9 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:P823 | S:S:F612 | 5.78 | 9 | Yes | Yes | 9 | 8 | 2 | 2 | R:R:C661 | R:R:F684 | 5.59 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:F684 | R:R:S664 | 5.28 | 9 | Yes | No | 8 | 6 | 1 | 2 | R:R:E837 | R:R:F668 | 9.33 | 9 | Yes | Yes | 9 | 9 | 1 | 2 | R:R:F668 | R:R:I841 | 3.77 | 0 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:Q681 | R:R:W742 | 6.57 | 9 | Yes | Yes | 9 | 9 | 1 | 2 | R:R:L773 | R:R:Q681 | 13.31 | 9 | No | Yes | 8 | 9 | 1 | 1 | R:R:E837 | R:R:Q681 | 2.55 | 9 | Yes | Yes | 9 | 9 | 1 | 1 | R:R:Q681 | W:W:?4 | 6.95 | 9 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:F684 | R:R:G685 | 3.01 | 9 | Yes | No | 8 | 8 | 1 | 1 | R:R:F684 | R:R:F688 | 7.5 | 9 | Yes | Yes | 8 | 8 | 1 | 2 | R:R:F684 | R:R:W818 | 3.01 | 9 | Yes | Yes | 8 | 9 | 1 | 1 | R:R:F684 | R:R:I841 | 17.58 | 9 | Yes | Yes | 8 | 9 | 1 | 1 | R:R:F684 | W:W:?4 | 19.07 | 9 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:G685 | W:W:?4 | 2.55 | 9 | No | Yes | 8 | 0 | 1 | 0 | R:R:F688 | R:R:T780 | 2.59 | 0 | Yes | No | 8 | 7 | 2 | 1 | R:R:F688 | R:R:F814 | 13.93 | 0 | Yes | Yes | 8 | 9 | 2 | 1 | R:R:L776 | R:R:Q735 | 10.65 | 0 | No | Yes | 8 | 9 | 1 | 2 | R:R:Q735 | R:R:T780 | 5.67 | 52 | Yes | No | 9 | 7 | 2 | 1 | R:R:I738 | R:R:L776 | 4.28 | 0 | No | No | 8 | 8 | 2 | 1 | R:R:I777 | R:R:L773 | 4.28 | 9 | No | No | 8 | 8 | 1 | 1 | R:R:L773 | W:W:?4 | 2.06 | 9 | No | Yes | 8 | 0 | 1 | 0 | R:R:L776 | W:W:?4 | 4.13 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:G778 | R:R:I777 | 3.53 | 0 | No | No | 5 | 8 | 2 | 1 | R:R:I777 | W:W:?4 | 17.02 | 9 | No | Yes | 8 | 0 | 1 | 0 | R:R:T780 | W:W:?4 | 6.59 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:A784 | R:R:F814 | 2.77 | 9 | No | Yes | 8 | 9 | 2 | 1 | R:R:A784 | R:R:F815 | 4.16 | 9 | No | Yes | 8 | 7 | 2 | 2 | R:R:F814 | R:R:F815 | 10.72 | 9 | Yes | Yes | 9 | 7 | 1 | 2 | R:R:F814 | R:R:W818 | 8.02 | 9 | Yes | Yes | 9 | 9 | 1 | 1 | R:R:A844 | R:R:F814 | 2.77 | 9 | No | Yes | 9 | 9 | 2 | 1 | R:R:F814 | W:W:?4 | 3.63 | 9 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:A840 | R:R:W818 | 7.78 | 0 | No | Yes | 9 | 9 | 2 | 1 | R:R:I841 | R:R:W818 | 2.35 | 9 | Yes | Yes | 9 | 9 | 1 | 1 | R:R:A844 | R:R:W818 | 2.59 | 9 | No | Yes | 9 | 9 | 2 | 1 | R:R:W818 | W:W:?4 | 33.96 | 9 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:I822 | R:R:P823 | 3.39 | 9 | Yes | Yes | 7 | 9 | 1 | 2 | R:R:I822 | W:W:?4 | 4.26 | 9 | Yes | Yes | 7 | 0 | 1 | 0 | R:R:E837 | R:R:Y825 | 2.24 | 9 | Yes | No | 9 | 9 | 1 | 1 | R:R:Y825 | W:W:?4 | 11.36 | 9 | No | Yes | 9 | 0 | 1 | 0 | R:R:E837 | W:W:?4 | 11.85 | 9 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:I841 | W:W:?4 | 2.13 | 9 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:I819 | R:R:I822 | 1.47 | 0 | No | Yes | 6 | 7 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 9.66 | Average Nodes In Shell | 29.00 | Average Hubs In Shell | 15.00 | Average Links In Shell | 44.00 | Average Links Mediated by Hubs In Shell | 41.00 |
| ![](/psngpcr/ligands/YP4/YP4_8WPU_W_W_4_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/YP4/YP4_8WPU_W_W_4_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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