Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:D258 4.604514
2R:R:W264 7.7975814
3R:R:P266 3.9125411
4R:R:P267 3.75167614
5R:R:V270 3.71413
6R:R:S272 3.7625415
7R:R:T274 1.945414
8R:R:L275 5.075414
9R:R:F278 5.55714716
10R:R:F279 7.488514
11R:R:L285 3.965408
12R:R:S293 3.5925444
13R:R:E295 8.2975413
14R:R:T297 4.64406
15R:R:I298 2.5175416
16R:R:I302 2.67667614
17R:R:V305 2.145415
18R:R:D306 5.54167617
19R:R:M309 2.6518
20R:R:P312 3.6475416
21R:R:V315 2.145405
22R:R:P320 4.8325411
23R:R:V322 3.535413
24R:R:I326 3.015614
25R:R:L334 2.33417
26R:R:M338 3.81333617
27R:R:L341 3.90833617
28R:R:L345 4.976516
29R:R:F350 7.166515
30R:R:S354 3.806516
31R:R:S356 4.4225415
32R:R:T358 5.25167618
33R:R:E359 4.574515
34R:R:L360 5.026517
35R:R:L362 4.9825416
36R:R:M363 4.418515
37R:R:I364 2.7625417
38R:R:V372 4.64516
39R:R:S378 3.768515
40R:R:M381 6.19333618
41R:R:L383 6.4025417
42R:R:W385 7.30286716
43R:R:A388 3.56418
44R:R:I401 3.61518
45R:R:L402 4.28333615
46R:R:S403 3.822518
47R:R:I404 4.38167616
48R:R:M407 4.48517
49R:R:T409 3.524514
50R:R:L411 4.085416
51R:R:L416 4.405615
52R:R:L418 3.78414
53R:R:K422 4.4975403
54R:R:L426 6.34406
55R:R:V437 4.49515
56R:R:L439 3.02513
57R:R:V445 3.955619
58R:R:I448 4.08617
59R:R:F449 7.275417
60R:R:L450 2.88617
61R:R:H452 2.782518
62R:R:I462 4.59167619
63R:R:F464 6.4717
64R:R:F466 5.71143717
65R:R:L493 2.935416
66R:R:L494 4.99429715
67R:R:C495 3.496519
68R:R:F497 5.396506
69R:R:W498 7.29717
70R:R:D501 4.34414
71R:R:G506 2.4418
72R:R:H507 4.95515
73R:R:W508 5.72571718
74R:R:T523 4.062519
75R:R:C525 3.35419
76R:R:L530 3.42819
77R:R:F533 4.5719
78R:R:I535 4.09718
79R:R:L536 5.5975419
80R:R:Y540 6.888516
81R:R:W545 5.304525
82R:R:L547 5.9175429
83R:R:T551 2.472509
84R:R:G554 1.8325439
85R:R:L555 4.052529
86R:R:C565 3.138527
87R:R:I566 3.726529
88R:R:T568 6.7925429
89R:R:F569 4.08875829
90R:R:V572 4.96629
91R:R:P574 3.6775428
92R:R:I575 5.16833629
93R:R:R579 7.615429
94R:R:I582 4.526528
95R:R:H583 13.045429
96R:R:L584 4.6775429
97R:R:H585 9.5525429
98R:R:C587 3.572528
99R:R:I588 3.175427
100R:R:C589 3.3525428
101R:R:L590 5.54429
102R:R:F591 6.176529
103R:R:I596 3.84526
104R:R:F597 6.46167629
105R:R:I601 7.324527
106R:R:V608 3.505426
107R:R:C612 4.74429
108R:R:V615 3.154528
109R:R:A616 2.0375429
110R:R:L619 3.968529
111R:R:H620 5.965629
112R:R:Y621 3.758526
113R:R:F623 9.09428
114R:R:L624 5.114529
115R:R:F627 5.44667629
116R:R:C628 3.21427
117R:R:W629 7.505829
118R:R:M630 6.5525429
119R:R:L632 5.374529
120R:R:E633 6.54286729
121R:R:G634 2.03409
122R:R:E636 4.372527
123R:R:L637 3.064529
124R:R:Y638 6.3075408
125R:R:V641 3.61529
126R:R:R643 3.0175407
127R:R:W654 5.8025406
128R:R:L655 4.03286727
129R:R:G659 3.254529
130R:R:Y660 7.674529
131R:R:V662 2.4625427
132R:R:P663 3.56729
133R:R:V667 2.7925429
134R:R:Y678 4.76857729
135R:R:R680 9.0025408
136R:R:R682 4.4175424
137R:R:Y683 11.214526
138R:R:W685 5.88667629
139R:R:L686 6.00429729
140R:R:F688 7.9775424
141R:R:F692 7.5525428
142R:R:F696 5.44571729
143R:R:L697 2.8875427
144R:R:I703 4.955429
145R:R:N707 6.78429
146R:R:F711 4.7628
147R:R:T714 3.242529
148R:R:L718 3.904528
149R:R:T739 2.47167629
150R:R:A742 2.245429
151R:R:Q745 7.515629
152R:R:L746 4.34427
153R:R:T752 5.3725429
154R:R:W753 8.575629
155R:R:I759 5.216528
156R:R:F760 8.76286728
157R:R:L767 4.42407
158R:R:F771 5.822529
159R:R:T772 2.815439
160R:R:L774 4.265427
161R:R:N775 5.8925429
162R:R:Q778 6.4875409
163R:R:F781 5.654528
164R:R:L782 3.83428
165R:R:Y783 6.692529
166R:R:H786 10.2325429
167R:R:C787 4.788529
168R:R:K792 3.7325429
169R:R:V793 5.05333629
170R:R:E796 8.8875428
171R:R:Y797 8.015429
172R:R:W800 7.05426
173H:H:?2 10.0425410
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I404 R:R:M407 16.20154.37YesYes167
2R:R:W498 R:R:W508 10.429417.81YesYes178
3R:R:L411 R:R:W508 22.5463.42YesYes168
4R:R:L411 R:R:M407 21.49275.65YesYes167
5R:R:I401 R:R:M381 12.70434.37YesYes188
6R:R:I401 R:R:V445 20.27271.54YesYes189
7R:R:F466 R:R:V445 15.76439.18YesYes179
8R:R:I448 R:R:L530 12.04261.43YesYes179
9R:R:L450 R:R:L530 17.15684.15YesYes179
10R:R:H452 R:R:L450 11.31692.57YesYes187
11R:R:L530 R:R:T455 13.16682.95YesNo199
12R:R:H452 R:R:T455 11.28542.74YesNo189
13R:R:L416 R:R:W508 63.7972.28YesYes158
14R:R:L416 R:R:L418 64.88055.54YesYes154
15R:R:L494 R:R:L536 30.91229.69YesYes159
16R:R:L418 R:R:L426 66.64562.77YesYes046
17R:R:I434 R:R:L426 99.8564.28NoYes046
18R:R:L494 R:R:Y540 30.95623.52YesYes156
19R:R:I434 R:R:V542 99.9664.61NoNo046
20R:R:E543 R:R:V542 99.97481.43NoNo056
21R:R:E543 R:R:S432 99.8882.87NoNo253
22R:R:R682 R:R:S432 1003.95YesNo243
23R:R:R682 R:R:Y683 76.56848.23YesYes246
24R:R:S443 R:R:V445 38.96641.62NoYes099
25R:R:I535 R:R:S443 23.16866.19YesNo089
26R:R:F466 R:R:I535 16.43388.79YesYes178
27R:R:A534 R:R:S443 61.47951.71NoNo099
28R:R:A534 R:R:W508 31.05212.59NoYes198
29R:R:H452 R:R:N454 11.30212.55YesNo085
30R:R:R682 R:R:W545 22.29692YesYes245
31R:R:I601 R:R:W545 13.12547.05YesYes275
32R:R:I601 R:R:L619 10.49271.43YesYes279
33R:R:I596 R:R:L619 19.35637.14YesYes269
34R:R:I596 R:R:V592 18.71953.07YesNo266
35R:R:I588 R:R:V592 18.58841.54YesNo276
36R:R:W685 R:R:Y683 70.00715.79YesYes296
37R:R:L619 R:R:W685 11.05263.42YesYes299
38R:R:W629 R:R:Y660 10.132412.54YesYes299
39R:R:L686 R:R:W685 12.044613.67YesYes299
40R:R:H620 R:R:L686 10.37245.14YesYes299
41R:R:F696 R:R:W685 39.24683.01YesYes299
42R:R:F696 R:R:H620 10.34556.79YesYes299
43R:R:H620 R:R:L624 12.8999YesYes299
44R:R:L624 R:R:P663 17.28723.28YesYes299
45R:R:G659 R:R:P663 14.96352.03YesYes299
46R:R:F623 R:R:F696 17.47154.29YesYes289
47R:R:F623 R:R:V700 11.11573.93YesNo288
48R:R:F627 R:R:V700 32.8172.62YesNo298
49R:R:F627 R:R:L746 17.75062.44YesYes297
50R:R:F696 R:R:W753 11.26256.01YesYes299
51R:R:V700 R:R:W753 22.02763.68NoYes289
52R:R:L757 R:R:W685 11.23973.42NoYes059
53R:R:L757 R:R:W753 11.170812.53NoYes059
54R:R:F627 R:R:N707 13.16133.62YesYes299
55R:R:F711 R:R:N707 12.87634.83YesYes289
56R:R:F711 R:R:L746 12.872.44YesYes287
57R:R:F711 R:R:T739 18.39272.59YesYes289
58R:R:E636 R:R:G649 12.13171.64YesNo077
59R:R:G649 R:R:R643 10.12464.5NoYes077
60R:R:A534 R:R:L536 30.62971.58NoYes199
61R:R:F533 R:R:L530 10.1552.44YesYes199
62R:R:F464 R:R:F466 13.56419.65YesYes177
63R:R:L426 R:R:Y540 32.73067.03YesYes066
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8IKJ
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRE5
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.2
Date 2024-02-14
D.O.I. 10.1016/j.molcel.2023.12.020
Net Summary
Imin 1.43
Number of Linked Nodes 505
Number of Links 761
Number of Hubs 173
Number of Links mediated by Hubs 570
Number of Communities 5
Number of Nodes involved in Communities 254
Number of Links involved in Communities 461
Path Summary
Number Of Nodes in MetaPath 64
Number Of Links MetaPath 63
Number of Shortest Paths 1220829
Length Of Smallest Path 3
Average Path Length 23.3122
Length of Longest Path 38
Minimum Path Strength 1.33
Average Path Strength 4.42989
Maximum Path Strength 19.58
Minimum Path Correlation 0.7
Average Path Correlation 0.977974
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 56.2863
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 65.0362
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
IdentifierN-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide
FormulaC8 H15 N O6
Molecular Weight221.208
SMILESCC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0



This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YDHB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi2-G13)/&β;1/&γ;23.12023-07-1210.1016/j.chembiol.2023.08.003
7YDJB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-G12)/&β;1/&γ;23.032023-07-12To be published
7YDMB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.892023-07-1210.1016/j.chembiol.2023.08.003
7YDPB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;23.12023-07-1210.1016/j.chembiol.2023.08.003
8IKJB2AdhesionAdhesionADGRE5Homo sapiens---3.22024-02-1410.1016/j.molcel.2023.12.020
8IKLB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1L-G13)/&β;1/&γ;22.332024-01-2410.1016/j.molcel.2023.12.020




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8IKJ.zip



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