psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S531	R:R:T548	4.8	Yes	No	0	9	4
2	R:R:I601	R:R:S531	4.64	No	Yes	2	7	9
3	R:R:E602	R:R:S531	7.19	No	Yes	0	7	9
4	R:R:S531	R:R:Y683	2.54	Yes	Yes	2	9	6
5	R:R:L547	R:R:S532	3	No	No	0	9	9
6	R:R:F533	R:R:L536	4.87	Yes	No	0	9	9
7	R:R:F533	R:R:T551	6.49	Yes	No	3	9	9
8	R:R:F533	R:R:L555	2.44	Yes	Yes	3	9	9
9	R:R:F533	R:R:W753	3.01	Yes	Yes	0	9	9
10	R:R:F533	R:R:F771	4.29	Yes	Yes	0	9	9
11	R:R:C776	R:R:F533	4.19	Yes	Yes	3	8	9
12	R:R:I535	R:R:R680	7.52	No	Yes	0	8	8
13	R:R:I535	R:R:Y683	6.04	No	Yes	0	8	6
14	R:R:F623	R:R:L536	7.31	No	No	0	8	9
15	R:R:L536	R:R:W685	6.83	No	No	0	9	9
16	R:R:L697	R:R:M537	2.83	No	No	0	7	9
17	R:R:F771	R:R:M537	3.73	Yes	No	0	9	9
18	R:R:V542	R:R:Y540	2.52	No	No	4	6	6
19	R:R:D762	R:R:Y540	5.75	No	No	4	5	6
20	R:R:D541	R:R:R680	4.76	No	Yes	0	5	8
21	R:R:D762	R:R:V542	5.84	No	No	4	5	6
22	R:R:E543	R:R:R682	9.3	No	No	2	5	4
23	R:R:E543	R:R:Y683	5.61	No	Yes	2	5	6
24	R:R:D544	R:R:W545	5.58	No	No	5	8	5
25	R:R:D544	R:R:K546	9.68	No	No	5	8	4
26	R:R:K546	R:R:W545	13.92	No	No	5	4	5
27	R:R:K546	R:R:Y769	5.97	No	No	0	4	9
28	R:R:L547	R:R:Y769	8.21	No	No	0	9	9
29	R:R:L547	R:R:T772	4.42	No	No	0	9	9
30	R:R:R552	R:R:T548	3.88	No	No	0	5	4
31	R:R:L555	R:R:T551	2.95	Yes	No	3	9	9
32	R:R:C776	R:R:T551	5.07	Yes	No	3	8	9
33	R:R:L555	R:R:S594	7.51	Yes	No	0	9	8
34	R:R:F597	R:R:L555	2.44	No	Yes	0	9	9
35	R:R:F591	R:R:L559	8.53	Yes	No	6	9	8
36	R:R:L559	R:R:S594	6.01	No	No	0	8	8
37	R:R:L559	R:R:T595	4.42	No	No	6	8	6
38	R:R:F560	R:R:L564	10.96	No	No	0	5	8
39	R:R:A780	R:R:C561	3.61	No	No	0	5	9
40	R:R:C587	R:R:L562	3.17	No	Yes	0	8	9
41	R:R:L562	R:R:L590	6.92	Yes	No	0	9	9
42	R:R:F591	R:R:L562	3.65	Yes	Yes	0	9	9
43	R:R:F591	R:R:L563	7.31	Yes	No	0	9	5
44	R:R:L564	R:R:Y783	4.69	No	Yes	0	8	9
45	R:R:C565	R:R:C587	5.46	No	No	0	7	8
46	R:R:C565	R:R:Y783	5.38	No	Yes	0	7	9
47	R:R:I566	R:R:L570	2.85	No	No	0	9	6
48	R:R:C587	R:R:I566	3.27	No	No	0	8	9
49	R:R:I566	R:R:I588	5.89	No	No	0	9	7
50	R:R:F569	R:R:T568	3.89	Yes	No	0	9	9
51	R:R:T568	R:R:Y783	2.5	No	Yes	0	9	9
52	R:R:F569	R:R:T580	2.59	Yes	No	0	9	9
53	R:R:F569	R:R:H583	5.66	Yes	No	0	9	9
54	R:R:F569	R:R:L584	2.44	Yes	Yes	0	9	9
55	R:R:C787	R:R:F569	4.19	No	Yes	0	9	9
56	R:R:L570	R:R:L584	2.77	No	Yes	0	6	9
57	R:R:L571	R:R:W800	5.69	No	No	0	7	6
58	R:R:I575	R:R:V572	6.14	Yes	No	0	9	9
59	R:R:E796	R:R:V572	5.7	No	No	0	8	9
60	R:R:E796	R:R:P574	15.72	No	No	0	8	8
61	R:R:I575	R:R:T580	3.04	Yes	No	0	9	9
62	R:R:I575	R:R:K792	2.91	Yes	No	0	9	9
63	R:R:I575	R:R:V793	3.07	Yes	No	0	9	9
64	R:R:E636	R:R:S578	7.19	No	No	0	7	8
65	R:R:E636	R:R:R579	5.82	No	No	0	7	9
66	R:R:H585	R:R:T581	2.74	Yes	No	0	9	9
67	R:R:I582	R:R:W629	8.22	No	Yes	1	8	9
68	R:R:I582	R:R:L632	2.85	No	No	1	8	9
69	R:R:E633	R:R:I582	9.56	Yes	No	1	9	8
70	R:R:E633	R:R:H583	13.54	Yes	No	1	9	9
71	R:R:H583	R:R:L748	7.71	No	Yes	1	9	8
72	R:R:H585	R:R:L584	5.14	Yes	Yes	0	9	9
73	R:R:I588	R:R:L584	2.85	No	Yes	0	7	9
74	R:R:H585	R:R:W629	17.98	Yes	Yes	0	9	9
75	R:R:C656	R:R:H585	2.95	No	Yes	0	4	9
76	R:R:L586	R:R:M630	2.83	No	No	0	9	9
77	R:R:C589	R:R:W629	2.61	No	Yes	1	8	9
78	R:R:C589	R:R:Y660	4.03	No	No	1	8	9
79	R:R:L590	R:R:Q778	2.66	No	No	0	9	9
80	R:R:F591	R:R:T595	5.19	Yes	No	6	9	6
81	R:R:G593	R:R:V592	3.68	No	No	0	9	6
82	R:R:C622	R:R:G593	3.92	No	No	0	7	9
83	R:R:I596	R:R:L619	2.85	No	No	0	6	9
84	R:R:F597	R:R:I601	10.05	No	No	0	9	7
85	R:R:F597	R:R:L619	6.09	No	No	0	9	9
86	R:R:I601	R:R:Y683	3.63	No	Yes	2	7	6
87	R:R:C684	R:R:N603	3.15	No	No	0	9	6
88	R:R:R613	R:R:V608	10.46	No	No	0	6	6
89	R:R:L610	R:R:L614	6.92	No	No	0	6	5
90	R:R:C612	R:R:C684	7.28	No	No	0	9	9
91	R:R:R613	R:R:Y678	4.12	No	Yes	0	6	9
92	R:R:C684	R:R:V615	3.42	No	No	0	9	8
93	R:R:A616	R:R:Y678	4	No	Yes	0	9	9
94	R:R:G617	R:R:Y678	5.79	No	Yes	0	8	9
95	R:R:H620	R:R:L624	3.86	Yes	Yes	0	9	9
96	R:R:H620	R:R:Y678	5.44	Yes	Yes	0	9	9
97	R:R:H620	R:R:L686	3.86	Yes	No	0	9	9
98	R:R:H620	R:R:S695	4.18	Yes	No	0	9	8
99	R:R:P663	R:R:Y621	5.56	Yes	No	0	9	6
100	R:R:F623	R:R:F696	3.22	No	No	0	8	9
101	R:R:L624	R:R:P663	4.93	Yes	Yes	0	9	9
102	R:R:I666	R:R:L624	8.56	No	Yes	0	8	9
103	R:R:L624	R:R:P699	3.28	Yes	No	0	9	9
104	R:R:A625	R:R:P663	3.74	No	Yes	0	9	9
105	R:R:F627	R:R:M630	3.73	No	No	0	9	9
106	R:R:F627	R:R:V700	11.8	No	No	0	9	8
107	R:R:F627	R:R:W753	12.03	No	Yes	0	9	9
108	R:R:C628	R:R:P663	3.77	No	Yes	0	7	9
109	R:R:L632	R:R:W629	6.83	No	Yes	1	9	9
110	R:R:G659	R:R:W629	2.81	No	Yes	0	9	9
111	R:R:W629	R:R:Y660	4.82	Yes	No	1	9	9
112	R:R:G750	R:R:M630	3.49	No	No	0	9	9
113	R:R:I703	R:R:S631	3.1	No	No	0	9	7
114	R:R:L632	R:R:L655	4.15	No	No	0	9	7
115	R:R:E633	R:R:L748	7.95	Yes	Yes	1	9	8
116	R:R:F639	R:R:L635	2.44	No	No	0	8	7
117	R:R:I710	R:R:L637	2.85	No	No	0	7	9
118	R:R:L637	R:R:T714	2.95	No	No	0	9	9
119	R:R:L637	R:R:Q745	2.66	No	No	0	9	9
120	R:R:F639	R:R:Y638	5.16	No	No	0	8	8
121	R:R:V642	R:R:Y638	7.57	No	No	0	9	8
122	R:R:F639	R:R:R643	5.34	No	No	0	8	7
123	R:R:L650	R:R:L655	2.77	No	No	0	5	7
124	R:R:S651	R:R:W654	2.47	No	No	0	6	6
125	R:R:P663	R:R:V662	3.53	Yes	No	0	9	7
126	R:R:I666	R:R:V662	3.07	No	No	0	8	7
127	R:R:I673	R:R:V669	3.07	No	No	0	5	7
128	R:R:F692	R:R:S670	6.61	Yes	No	0	8	9
129	R:R:S670	R:R:S695	4.89	No	No	0	9	8
130	R:R:K676	R:R:Y674	8.36	No	Yes	0	3	5
131	R:R:G677	R:R:Y674	4.35	No	Yes	0	8	5
132	R:R:Q690	R:R:Y674	14.65	No	Yes	0	2	5
133	R:R:F692	R:R:G677	3.01	Yes	No	0	8	8
134	R:R:F692	R:R:Y678	4.13	Yes	Yes	0	8	9
135	R:R:D687	R:R:R680	5.96	No	Yes	0	5	8
136	R:R:F688	R:R:R680	11.76	No	Yes	0	4	8
137	R:R:R682	R:R:Y683	6.17	No	Yes	2	4	6
138	R:R:L686	R:R:W685	15.94	No	No	0	9	9
139	R:R:F692	R:R:L686	4.87	Yes	No	0	8	9
140	R:R:F688	R:R:L693	2.44	No	No	0	4	7
141	R:R:L697	R:R:W694	7.97	No	No	0	7	8
142	R:R:F696	R:R:V700	2.62	No	No	0	9	8
143	R:R:L697	R:R:L757	2.77	No	No	0	7	5
144	R:R:G698	R:R:P699	4.06	No	No	0	8	9
145	R:R:I704	R:R:L705	2.85	No	No	0	6	5
146	R:R:L749	R:R:N707	15.1	No	No	0	9	9
147	R:R:F711	R:R:V715	2.62	Yes	No	0	8	6
148	R:R:A742	R:R:F711	2.77	No	Yes	0	9	8
149	R:R:F711	R:R:L746	2.44	Yes	No	0	8	7
150	R:R:K717	R:R:T713	3	No	No	0	8	6
151	R:R:Q720	R:R:W716	10.95	No	No	0	5	8
152	R:R:L718	R:R:L738	4.15	No	No	0	8	9
153	R:R:F722	R:R:M729	4.98	No	Yes	0	8	7
154	R:R:F722	R:R:K734	8.69	No	No	0	8	7
155	R:R:I725	R:R:N726	9.91	No	No	0	8	8
156	R:R:M729	R:R:N726	5.61	Yes	No	0	7	8
157	R:R:D728	R:R:P727	4.83	No	No	0	8	6
158	R:R:D728	R:R:M729	2.77	No	Yes	0	8	7
159	R:R:K733	R:R:M729	4.32	No	Yes	0	5	7
160	R:R:L732	R:R:R736	4.86	No	No	0	8	8
161	R:R:A744	R:R:L785	3.15	No	Yes	0	9	8
162	R:R:C751	R:R:L746	4.76	No	No	0	5	7
163	R:R:F747	R:R:T752	7.78	Yes	No	0	5	9
164	R:R:F747	R:R:Q778	3.51	Yes	No	0	5	9
165	R:R:F747	R:R:F781	12.86	Yes	No	0	5	8
166	R:R:F747	R:R:L785	2.44	Yes	Yes	0	5	8
167	R:R:L748	R:R:L782	2.77	Yes	No	0	8	8
168	R:R:H786	R:R:L748	6.43	No	Yes	0	9	8
169	R:R:N775	R:R:T752	4.39	Yes	No	0	9	9
170	R:R:N775	R:R:W753	19.21	Yes	Yes	0	9	9
171	R:R:Q778	R:R:W753	5.48	No	Yes	0	9	9
172	R:R:F755	R:R:V754	3.93	Yes	No	0	8	6
173	R:R:F755	R:R:L767	2.44	Yes	No	0	8	7
174	R:R:F755	R:R:V770	5.24	Yes	No	0	8	6
175	R:R:G756	R:R:I759	3.53	No	No	0	9	8
176	R:R:F771	R:R:G756	6.02	Yes	No	0	9	9
177	R:R:F758	R:R:F760	4.29	No	No	0	8	8
178	R:R:I759	R:R:T768	10.64	No	No	0	8	7
179	R:R:D761	R:R:F760	3.58	No	No	0	4	8
180	R:R:D761	R:R:R763	10.72	No	No	0	4	4
181	R:R:F771	R:R:N775	8.46	Yes	Yes	0	9	9
182	R:R:F781	R:R:L777	3.65	No	No	0	8	8
183	R:R:G779	R:R:L782	5.13	No	No	0	9	8
184	R:R:C787	R:R:Y783	9.41	No	Yes	0	9	9
185	R:R:K792	R:R:N790	2.8	No	No	0	9	9
186	R:R:N790	R:R:V793	7.39	No	No	0	9	9
187	R:R:E795	R:R:K791	12.15	No	No	0	6	8
188	R:R:R794	R:R:R798	4.26	No	No	0	8	4
189	R:R:E796	R:R:K799	8.1	No	No	0	8	5
190	R:R:V804	R:R:W800	7.36	No	No	0	5	6
191	R:R:Q745	R:R:R579	2.34	No	No	0	9	9
192	R:R:L664	R:R:Y621	2.34	No	No	0	8	6
193	R:R:F711	R:R:Q745	2.34	Yes	No	0	8	9
194	R:R:L765	R:R:Y769	2.34	No	No	0	3	9
195	R:R:E633	R:R:R579	2.33	Yes	No	0	9	9
196	R:R:E795	R:R:R798	2.33	No	No	0	6	4
197	R:R:L549	R:R:W545	2.28	No	No	0	5	5
198	R:R:L650	R:R:W654	2.28	No	No	0	5	6
199	R:R:F760	R:R:H539	2.26	No	No	0	8	6
200	R:R:G605	R:R:G606	2.11	No	No	0	7	6
201	R:R:G661	R:R:P663	2.03	No	Yes	0	9	9
202	R:R:C776	R:R:G554	1.96	Yes	No	0	8	9
203	R:R:C612	R:R:G679	1.96	No	No	0	9	9
204	R:R:A599	R:R:G600	1.95	No	No	0	6	8
205	R:R:G554	R:R:V553	1.84	No	No	0	9	7
206	R:R:G668	R:R:V667	1.84	No	No	0	6	9
207	R:R:A534	R:R:A538	1.79	No	No	0	9	9
208	R:R:G634	R:R:I710	1.76	No	No	0	9	7
209	R:R:A534	R:R:S532	1.71	No	No	0	9	9
210	R:R:G634	R:R:L749	1.71	No	No	0	9	9
211	R:R:C776	R:R:T772	1.69	Yes	No	0	8	9
212	R:R:G577	R:R:Q576	1.64	No	No	0	8	8
213	R:R:G606	R:R:Q607	1.64	No	No	0	6	4
214	R:R:D687	R:R:P681	1.61	No	No	0	5	3
215	R:R:V766	R:R:V770	1.6	No	No	0	6	6
216	R:R:T714	R:R:V641	1.59	No	No	0	9	9
217	R:R:T713	R:R:V642	1.59	No	No	0	6	9
218	R:R:T719	R:R:V715	1.59	No	No	0	8	6
219	R:R:A626	R:R:L586	1.58	No	No	0	8	9
220	R:R:A780	R:R:L777	1.58	No	No	0	5	8
221	R:R:C706	R:R:N707	1.57	No	No	0	5	9
222	R:R:I596	R:R:V592	1.54	No	No	0	6	6
223	R:R:I704	R:R:V700	1.54	No	No	0	6	8
224	R:R:I550	R:R:T772	1.52	No	No	0	8	9
225	R:R:K717	R:R:V641	1.52	No	No	0	8	9
226	R:R:I743	R:R:T739	1.52	No	No	0	6	9
227	R:R:F755	R:R:G756	1.51	Yes	No	0	8	9
228	R:R:L562	R:R:S558	1.5	Yes	No	0	9	9
229	R:R:L557	R:R:V553	1.49	No	No	0	6	7
230	R:R:L640	R:R:V641	1.49	No	No	0	6	9
231	R:R:L665	R:R:V669	1.49	No	No	0	5	7
232	R:R:L705	R:R:T701	1.47	No	No	0	5	7
233	R:R:L757	R:R:T701	1.47	No	No	0	5	7
234	R:R:L718	R:R:T741	1.47	No	No	0	8	9
235	R:R:L738	R:R:T719	1.47	No	No	0	9	8
236	R:R:I725	R:R:K721	1.45	No	No	0	8	9
237	R:R:P574	R:R:R573	1.44	No	No	0	8	8
238	R:R:E724	R:R:S723	1.44	No	No	0	8	8
239	R:R:I596	R:R:L618	1.43	No	No	0	6	8
240	R:R:I658	R:R:L650	1.43	No	No	0	6	5
241	R:R:I743	R:R:L785	1.43	No	Yes	0	6	8
242	R:R:I703	R:R:N707	1.42	No	No	0	9	9
243	R:R:C656	R:R:R653	1.39	No	No	0	4	5
244	R:R:A737	R:R:F722	1.39	No	No	0	6	8
245	R:R:L555	R:R:L598	1.38	Yes	No	0	9	9
246	R:R:L784	R:R:L788	1.38	No	No	0	5	8
247	R:R:L785	R:R:L789	1.38	Yes	No	0	8	8
248	R:R:L774	R:R:N775	1.37	No	Yes	0	7	9
249	R:R:K721	R:R:Q720	1.36	No	No	0	9	5
250	R:R:E689	R:R:Q690	1.27	No	No	0	3	2
251	R:R:V667	R:R:Y621	1.26	No	No	0	9	6
252	R:R:V667	R:R:Y678	1.26	No	Yes	0	9	9
253	R:R:F758	R:R:L767	1.22	No	No	0	8	7
254	R:R:N603	R:R:R611	1.21	No	No	0	6	7
255	R:R:I673	R:R:Y674	1.21	No	Yes	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S531	4.7925	4	2	9
2	R:R:F533	4.215	6	3	9
3	R:R:L555	3.344	5	3	9
4	R:R:L562	3.81	4	0	9
5	R:R:F569	3.754	5	0	9
6	R:R:I575	3.79	4	0	9
7	R:R:L584	3.3	4	0	9
8	R:R:H585	7.2025	4	0	9
9	R:R:F591	6.17	4	6	9
10	R:R:H620	4.335	4	0	9
11	R:R:L624	5.1575	4	0	9
12	R:R:W629	7.21167	6	1	9
13	R:R:E633	8.345	4	1	9
14	R:R:P663	3.92667	6	0	9
15	R:R:Y674	7.1425	4	0	5
16	R:R:Y678	4.12333	6	0	9
17	R:R:R680	7.5	4	0	8
18	R:R:Y683	4.798	5	2	6
19	R:R:F692	4.655	4	0	8
20	R:R:F711	2.5425	4	0	8
21	R:R:M729	4.42	4	0	7
22	R:R:F747	6.6475	4	0	5
23	R:R:L748	6.215	4	1	8
24	R:R:W753	9.9325	4	0	9
25	R:R:F755	3.28	4	0	8
26	R:R:F771	5.625	4	0	9
27	R:R:N775	8.3575	4	0	9
28	R:R:C776	3.2275	4	3	8
29	R:R:Y783	5.495	4	0	9
30	R:R:L785	2.1	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L547	R:R:T772	10.6798	4.42	No	No	0	9	9
2	R:R:C776	R:R:T772	12.752	1.69	Yes	No	0	8	9
3	R:R:C776	R:R:F533	15.5471	4.19	Yes	Yes	3	8	9
4	R:R:F597	R:R:L555	21.8709	2.44	No	Yes	0	9	9
5	R:R:F597	R:R:I601	15.1428	10.05	No	No	0	9	7
6	R:R:F533	R:R:L536	40.5612	4.87	Yes	No	0	9	9
7	R:R:F533	R:R:W753	58.1323	3.01	Yes	Yes	0	9	9
8	R:R:F533	R:R:F771	17.3757	4.29	Yes	Yes	0	9	9
9	R:R:L536	R:R:W685	39.4394	6.83	No	No	0	9	9
10	R:R:L555	R:R:S594	17.7211	7.51	Yes	No	0	9	8
11	R:R:F591	R:R:L559	17.9138	8.53	Yes	No	6	9	8
12	R:R:L559	R:R:S594	17.9754	6.01	No	No	0	8	8
13	R:R:C565	R:R:Y783	44.0309	5.38	No	Yes	0	7	9
14	R:R:C565	R:R:C587	44.1514	5.46	No	No	0	7	8
15	R:R:C587	R:R:L562	100	3.17	No	Yes	0	8	9
16	R:R:F591	R:R:L562	19.3703	3.65	Yes	Yes	0	9	9
17	R:R:Q778	R:R:W753	75.6151	5.48	No	Yes	0	9	9
18	R:R:L590	R:R:Q778	80.4128	2.66	No	No	0	9	9
19	R:R:C587	R:R:I566	56.293	3.27	No	No	0	8	9
20	R:R:I566	R:R:L570	28.109	2.85	No	No	0	9	6
21	R:R:I566	R:R:I588	28.109	5.89	No	No	0	9	7
22	R:R:F569	R:R:T568	21.7183	3.89	Yes	No	0	9	9
23	R:R:T568	R:R:Y783	21.9566	2.5	No	Yes	0	9	9
24	R:R:C787	R:R:F569	21.6969	4.19	No	Yes	0	9	9
25	R:R:C787	R:R:Y783	21.9566	9.41	No	Yes	0	9	9
26	R:R:F569	R:R:L584	43.027	2.44	Yes	Yes	0	9	9
27	R:R:L570	R:R:L584	27.86	2.77	No	Yes	0	6	9
28	R:R:I588	R:R:L584	27.8654	2.85	No	Yes	0	7	9
29	R:R:F569	R:R:T580	20.9071	2.59	Yes	No	0	9	9
30	R:R:F569	R:R:H583	65.5913	5.66	Yes	No	0	9	9
31	R:R:I575	R:R:T580	19.033	3.04	Yes	No	0	9	9
32	R:R:E633	R:R:R579	56.2528	2.33	Yes	No	0	9	9
33	R:R:E633	R:R:H583	56.8419	13.54	Yes	No	1	9	9
34	R:R:H585	R:R:L584	13.764	5.14	Yes	Yes	0	9	9
35	R:R:H585	R:R:W629	10.5646	17.98	Yes	Yes	0	9	9
36	R:R:H620	R:R:L686	20.9633	3.86	Yes	No	0	9	9
37	R:R:L686	R:R:W685	38.6683	15.94	No	No	0	9	9
38	R:R:F692	R:R:L686	17.4319	4.87	Yes	No	0	8	9
39	R:R:H620	R:R:L624	11.5927	3.86	Yes	Yes	0	9	9
40	R:R:G634	R:R:I710	11.3866	1.76	No	No	0	9	7
41	R:R:I710	R:R:L637	13.2607	2.85	No	No	0	7	9
42	R:R:L637	R:R:Q745	33.4261	2.66	No	No	0	9	9
43	R:R:Q745	R:R:R579	50.9571	2.34	No	No	0	9	9
44	R:R:K717	R:R:T713	11.3839	3	No	No	0	8	6
45	R:R:K717	R:R:V641	13.2607	1.52	No	No	0	8	9
46	R:R:T714	R:R:V641	17.0036	1.59	No	No	0	9	9
47	R:R:L637	R:R:T714	18.7224	2.95	No	No	0	9	9
48	R:R:F711	R:R:Q745	16.61	2.34	Yes	No	0	8	9
49	R:R:N775	R:R:W753	14.0157	19.21	Yes	Yes	0	9	9
50	R:R:F771	R:R:N775	13.2741	8.46	Yes	Yes	0	9	9
51	R:R:F755	R:R:G756	16.5163	1.51	Yes	No	0	8	9
52	R:R:F771	R:R:G756	21.3676	6.02	Yes	No	0	9	9
53	R:R:I601	R:R:Y683	10.0693	3.63	No	Yes	2	7	6
54	R:R:L562	R:R:L590	80.6699	6.92	Yes	No	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7YDJ_nogp

PDB Summary
PDB	7YDJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	244
Number of Links	255
Number of Hubs	30
Number of Links mediated by Hubs	114
Number of Communities	6
Number of Nodes involved in Communities	26
Number of Links involved in Communities	30

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	50929
Length Of Smallest Path	3
Average Path Length	16.4903
Length of Longest Path	32
Minimum Path Strength	1.26
Average Path Strength	4.94779
Maximum Path Strength	15.62
Minimum Path Correlation	0.7
Average Path Correlation	0.934471
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	51.191
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.9648
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• response to stimulus • immune response • immune system process • regulation of biological process • signaling • biological regulation • cell-cell signaling • cellular process • cell communication • cellular response to stimulus • regulation of cellular process • cell surface receptor signaling pathway • signal transduction • cell adhesion • defense response • response to stress • inflammatory response • G protein-coupled receptor signaling pathway • cellular anatomical structure • anchoring junction • cell junction • focal adhesion • cell-substrate junction • membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle
Gene Ontology	Cellular Component	• cellular anatomical structure • anchoring junction • cell junction • focal adhesion • cell-substrate junction • membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cell periphery • plasma membrane • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • organelle membrane • secretory granule membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • synapse • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • protein phosphatase activator activity • enzyme activator activity • phosphatase activator activity • molecular function activator activity • phosphatase regulator activity • protein phosphatase regulator activity • protein phosphatase binding • phosphatase binding • protein phosphatase 2A binding • D5 dopamine receptor binding • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • response to xenobiotic stimulus • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • circulatory system process • regulation of blood pressure • blood circulation • cellular developmental process • cell differentiation • regulation of vascular associated smooth muscle cell migration • negative regulation of locomotion • vascular associated smooth muscle cell migration • regulation of cell motility • negative regulation of vascular associated smooth muscle cell migration • regulation of smooth muscle cell migration • smooth muscle cell migration • muscle cell migration • negative regulation of smooth muscle cell migration • regulation of locomotion • regulation of cell migration • negative regulation of cell motility • locomotion • negative regulation of cell migration • regulation of fibroblast migration • fibroblast migration • ameboidal-type cell migration • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • regulation of developmental process • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • Rho-activating G protein-coupled receptor signaling pathway • catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process • macromolecule catabolic process • regulation of ubiquitin-dependent protein catabolic process • modification-dependent macromolecule catabolic process • protein metabolic process • regulation of protein metabolic process • proteasomal protein catabolic process • protein catabolic process • regulation of macromolecule metabolic process • regulation of catabolic process • regulation of proteasomal ubiquitin-dependent protein catabolic process • modification-dependent protein catabolic process • regulation of proteasomal protein catabolic process • ubiquitin-dependent protein catabolic process • macromolecule metabolic process • regulation of protein catabolic process • Rho protein signal transduction • TOR signaling • regulation of TOR signaling • regulation of signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • regulation of vascular associated smooth muscle cell proliferation • negative regulation of cell population proliferation • regulation of smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell proliferation • smooth muscle cell proliferation • negative regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • limb development • appendage development • embryonic limb morphogenesis • embryonic morphogenesis • embryonic appendage morphogenesis • appendage morphogenesis • embryonic digit morphogenesis • limb morphogenesis • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • ciliary basal body • brush border membrane • cluster of actin-based cell projections • brush border • apical part of cell • plasma membrane region • apical plasma membrane • cell projection membrane • somatodendritic compartment • cell body • neuronal cell body • lateral plasma membrane
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P48960
Sequence	>7YDJ_nogp_Chain_R S S F A I L M A H Y D V E D W K L T L I T R V G L A L S L F C L L L C I L T F L L V R P I Q G S R T T I H L H L C I C L F V G S T I F L A G I E N E G G Q V G L R C R L V A G L L H Y C F L A A F C W M S L E G L E L Y F L V V R V F Q G Q G L S T R W L C L I G Y G V P L L I V G V S A A I Y S K G Y G R P R Y C W L D F E Q G F L W S F L G P V T F I I L C N A V I F V T T V W K L T Q K F S E I N P D M K K L K K A R A L T I T A I A Q L F L L G C T W V F G L F I F D D R S L V L T Y V F T I L N C L Q G A F L Y L L H C L L N K K V R E E Y R K W A C L V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YDH	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi2-G13)/β1/γ2	3.1	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	7YDH (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		3.1	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	7YDJ	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi1-G12)/β1/γ2	3.03	2023-07-12	To be published
	7YDJ (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		3.03	2023-07-12	To be published
	7YDM	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.89	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	7YDM (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		2.89	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	7YDP	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	7YDP (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		3.1	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	8IKL	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi1L-G13)/β1/γ2	2.33	2024-01-24	doi.org/10.1016/j.molcel.2023.12.020
	8IKL (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		2.33	2024-01-24	doi.org/10.1016/j.molcel.2023.12.020
	8IKJ	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	-	3.2	2024-02-14	doi.org/10.1016/j.molcel.2023.12.020

there is no ligand in network 7YDJ_nogp

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.