Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L41 3.5825416
2A:A:L43 2.2125417
3A:A:L45 3.555418
4A:A:F212 5.425419
5A:A:V214 4.18333616
6A:A:F219 6.375418
7A:A:H220 7.334137
8A:A:M221 3.362518
9A:A:F222 7.49754137
10A:A:F238 5.966509
11A:A:I245 2.7825417
12A:A:F246 3.015409
13A:A:Y253 6.785408
14A:A:R265 8.64179
15A:A:F273 3.6525189
16A:A:W277 6.036186
17A:A:W281 9.6525465
18A:A:F290 4.722519
19A:A:L297 2.386508
20A:A:F312 2.525608
21A:A:E330 3.8125403
22A:A:K338 5.0854195
23A:A:F340 6.2775407
24A:A:F345 4.52508
25A:A:S349 2.685407
26A:A:D354 8.3925403
27A:A:Y360 8.195408
28A:A:T364 6.275419
29A:A:F376 5.63418
30A:A:D378 7.7825407
31A:A:I383 3.17418
32A:A:L388 2.13408
33B:B:L7 2.9975408
34B:B:V40 2.93754223
35B:B:R49 3.41437
36B:B:L51 5.6825439
37B:B:R52 7.65407
38B:B:H54 5.77409
39B:B:K57 9.995469
40B:B:Y59 6.3025468
41B:B:W63 4.17714737
42B:B:Q75 6.045469
43B:B:W82 7.72833639
44B:B:Y85 8.55434
45B:B:H91 4.2125165
46B:B:W99 7.102509
47B:B:C103 2.5825408
48B:B:Y105 2.786506
49B:B:G115 1.9409
50B:B:Y124 3.47506
51B:B:E130 5.9575403
52B:B:H142 5.52429749
53B:B:Y145 4.8425848
54B:B:L146 2.9675447
55B:B:C148 3.1125426
56B:B:R150 4.8426
57B:B:S160 3.225426
58B:B:D163 8.8875449
59B:B:L168 2.8425406
60B:B:W169 7.26143748
61B:B:F180 6.156527
62B:B:H183 6.806529
63B:B:D186 5.432549
64B:B:L190 2.895425
65B:B:F199 4.86429
66B:B:K209 9.925426
67B:B:L210 3.335455
68B:B:W211 8.054528
69B:B:Q220 7.82457
70B:B:F222 6.5575458
71B:B:H225 6.475659
72B:B:D228 6.832509
73B:B:I232 3.256558
74B:B:F235 5.513336256
75B:B:N237 5.1525405
76B:B:F241 4.28756
77B:B:T243 3.638558
78B:B:D247 7.5575459
79B:B:C250 2.7425408
80B:B:R251 8.6825408
81B:B:F253 5.3525456
82B:B:D258 9.195457
83B:B:M262 5.374104
84B:B:Y264 4.758336105
85B:B:T274 3.025468
86B:B:F278 4.838507
87B:B:G282 2.2154259
88B:B:R283 4.9025229
89B:B:Y289 4.543336107
90B:B:N295 5.23754106
91B:B:W297 2.79254108
92B:B:H311 7.0065119
93B:B:R314 10.268568
94B:B:T321 5.525437
95B:B:W332 7.54857769
96B:B:D333 5.60754119
97B:B:L336 4.17437
98B:B:K337 5.04754116
99B:B:I338 2.87435
100B:B:W339 5.9865119
101G:G:V30 2.9825408
102G:G:D48 5.55509
103G:G:N59 4.675409
104G:G:F61 4.67333638
105R:R:F533 3.89599
106R:R:M537 3.01599
107R:R:R579 5.99754149
108R:R:H583 7.0754149
109R:R:H585 7.39489
110R:R:C589 2.565488
111R:R:I596 2.5525406
112R:R:H620 3.95409
113R:R:Y621 3.0575406
114R:R:W629 6.23875889
115R:R:L632 2.38489
116R:R:E633 6.5725149
117R:R:F645 4.73519
118R:R:Y660 6.28489
119R:R:P663 2.974589
120R:R:Y674 6.92475
121R:R:Y678 2.93833679
122R:R:R680 4.88254298
123R:R:W685 5.655409
124R:R:F692 4.85578
125R:R:L697 3.855497
126R:R:F711 4.07408
127R:R:I725 3.87254128
128R:R:N726 4.434128
129R:R:I740 1.7225407
130R:R:Q745 3.4025409
131R:R:F747 5.935405
132R:R:W753 6.35167699
133R:R:F755 2.5525408
134R:R:Y769 4.4054159
135R:R:F771 4.908599
136R:R:N775 6.398599
137R:R:C776 2.8775408
138R:R:Y783 5.3356279
139R:R:C787 3.67754279
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:C114 B:B:V100 21.9041.71NoNo089
2B:B:Q75 B:B:W99 22.99874.38YesYes099
3B:B:Q75 B:B:V100 26.67382.87YesNo099
4B:B:G330 B:B:L336 13.21071.71NoYes057
5B:B:C317 B:B:G330 17.53791.96NoNo075
6B:B:C317 B:B:S316 17.83623.44NoNo079
7B:B:S316 B:B:W332 18.17143.71NoYes099
8B:B:W332 B:B:Y59 74.16293.86YesYes698
9R:R:I582 R:R:W629 53.48537.05NoYes089
10R:R:E633 R:R:I582 54.13226.83YesNo098
11R:R:E633 R:R:R579 59.230810.47YesYes1499
12A:A:Y391 R:R:R579 77.38922.06NoYes049
13A:A:Y391 R:R:L640 77.71798.21NoNo046
14A:A:N387 R:R:L640 77.01482.75NoNo086
15A:A:I383 A:A:N387 77.16974.25YesNo088
16A:A:I383 A:A:L41 79.89782.85YesYes186
17A:A:F219 A:A:L41 80.67466.09YesYes186
18A:A:F212 A:A:F219 81.173112.86YesYes198
19A:A:F212 A:A:M221 81.80412.49YesYes198
20A:A:L45 A:A:M221 80.19554.24YesYes188
21A:A:K53 A:A:L45 91.17855.64NoYes098
22A:A:G47 A:A:K53 91.40263.49NoNo099
23A:A:G47 A:A:L46 91.95311.71NoNo098
24A:A:L44 A:A:L46 99.99164.15NoNo098
25A:A:F238 A:A:L44 10013.4YesNo099
26A:A:F238 B:B:W99 33.79229.02YesYes099
27A:A:I245 A:A:L45 10.52832.85YesYes178
28A:A:F246 A:A:L46 49.79663.65YesNo098
29A:A:F290 A:A:I245 12.32472.51YesYes197
30B:B:C114 B:B:G115 17.34141.96NoYes089
31B:B:R314 B:B:W332 64.473416.99YesYes689
32A:A:C237 B:B:Y59 65.6794.03NoYes088
33A:A:F246 A:A:V248 15.73562.62YesNo097
34A:A:F246 A:A:F273 18.41832.14YesYes099
35A:A:F246 A:A:L289 15.44653.65YesNo099
36A:A:F345 A:A:V248 15.19852.62YesNo087
37A:A:F273 A:A:F345 24.70635.36YesYes098
38A:A:F345 A:A:L289 15.1784.87YesNo089
39A:A:F363 A:A:L291 26.60176.09NoNo058
40A:A:F345 A:A:L291 27.61922.44YesNo088
41A:A:F345 A:A:L270 26.59967.31YesNo086
42A:A:F312 A:A:L270 25.58372.44YesNo086
43A:A:F273 A:A:W277 12.35873.01YesYes1896
44A:A:R280 A:A:W281 12.98413.99NoYes055
45A:A:R280 A:A:R283 12.65746.4NoNo053
46A:A:R283 A:A:R356 12.6689.6NoNo032
47A:A:D354 A:A:R356 12.678819.06YesNo032
48A:A:F363 A:A:K338 16.40067.44NoYes1955
49A:A:F312 A:A:F340 11.38813.22YesYes087
50R:R:C787 R:R:F569 11.21842.79YesNo099
51R:R:F569 R:R:H583 12.7196.79NoYes099
52R:R:H583 R:R:R579 17.49429.03YesYes1499
53R:R:H786 R:R:L785 12.5462.57NoNo098
54R:R:H786 R:R:L748 13.110112.86NoNo098
55B:B:G115 B:B:T102 17.49611.82YesNo098
56B:B:C148 B:B:T102 16.79553.38YesNo068
57B:B:C148 B:B:S160 12.09961.72YesYes266
58B:B:A203 B:B:V187 10.3255.09NoNo089
59B:B:A203 B:B:G202 11.1761.95NoNo086
60B:B:R314 B:B:T274 26.40532.59YesYes688
61B:B:G288 B:B:T274 17.90261.82NoYes078
62B:B:A287 B:B:G288 18.22021.95NoNo067
63B:B:A287 B:B:Y289 17.92555.34NoYes067
64B:B:W297 B:B:Y289 25.07852.89YesYes1087
65B:B:W297 B:B:Y264 24.08962.89YesYes1085
66B:B:M262 B:B:Y264 17.61139.58YesYes1045
67B:B:L30 B:B:M262 16.83134.24NoYes054
68B:B:L30 G:G:A34 13.09281.58NoNo056
69B:B:I33 G:G:A34 12.27853.25NoNo036
70B:B:A28 B:B:I33 11.46373.25NoNo043
71B:B:D290 B:B:R314 48.738413.1NoYes668
72B:B:C271 B:B:D290 48.7713.11NoNo056
73B:B:C271 B:B:D291 15.52536.22NoNo058
74B:B:D291 B:B:Y289 15.00983.45NoYes087
75B:B:C271 B:B:G272 32.98311.96NoNo054
76B:B:G272 B:B:I273 32.72621.76NoNo046
77B:B:C250 B:B:I273 34.85973.27YesNo086
78B:B:C250 B:B:Y264 15.64464.03YesYes085
79B:B:G115 B:B:L146 13.32541.71YesYes097
80B:B:H142 B:B:W169 12.78863.17YesYes498
81B:B:I157 B:B:W169 13.33783.52NoYes078
82B:B:F151 B:B:I157 12.86886.28NoNo097
83B:B:A106 B:B:F151 12.39928.32NoNo069
84B:B:L117 B:B:W99 19.1134.56NoYes099
85B:B:A106 B:B:S108 10.51531.71NoNo066
86B:B:L285 B:B:Y264 19.75623.52NoYes065
87B:B:F278 B:B:L285 19.00329.74YesNo076
88B:B:F235 B:B:F278 23.42627.5YesYes067
89B:B:F235 B:B:N237 11.93687.25YesYes065
90B:B:G244 B:B:T243 22.36581.82NoYes058
91R:R:L586 R:R:W629 29.1662.28NoYes099
92R:R:L586 R:R:M630 28.66512.83NoNo099
93R:R:F627 R:R:M630 28.17333.73NoNo099
94R:R:F627 R:R:W753 25.769714.03NoYes099
95R:R:F533 R:R:W753 15.48164.01YesYes999
96R:R:G659 R:R:W629 15.87355.63NoYes899
97R:R:C628 R:R:G659 15.82821.96NoNo879
98R:R:C628 R:R:V662 14.9881.71NoNo877
99R:R:I666 R:R:V662 14.99693.07NoNo087
100R:R:I666 R:R:L624 13.93384.28NoNo089
101R:R:H620 R:R:L624 13.68475.14YesNo099
102B:B:L117 B:B:Y145 18.80782.34NoYes098
103B:B:C250 B:B:G244 22.60381.96YesNo085
104A:A:C237 A:A:F238 65.71122.79NoYes089
105A:A:W281 B:B:R314 11.529613.99YesYes658
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7YDM
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRE5
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.89
Date 2023-07-12
D.O.I. 10.1016/j.chembiol.2023.08.003
Net Summary
Imin 1.71
Number of Linked Nodes 824
Number of Links 969
Number of Hubs 139
Number of Links mediated by Hubs 516
Number of Communities 29
Number of Nodes involved in Communities 189
Number of Links involved in Communities 252
Path Summary
Number Of Nodes in MetaPath 106
Number Of Links MetaPath 105
Number of Shortest Paths 771672
Length Of Smallest Path 3
Average Path Length 23.7343
Length of Longest Path 50
Minimum Path Strength 1.17
Average Path Strength 5.12733
Maximum Path Strength 17
Minimum Path Correlation 0.72
Average Path Correlation 0.977943
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.94118
Average % Of Corr. Nodes 53.3429
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.3787
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7YDM_Chain_A
SAEDKAAVE RSKMIEKQL QKDKQVYRR TLRLLLLGA DNSGKSTIV 
KQMRIYVKT SGIFETKFQ VDKVNFHMF DVGAQRDER RKWIQCFND 
VTAIIFVVD SSDYNRLQE ALNDFKSIW NNRWLRTIS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRKEFVDIS TASGDGRHI CYPHFTCSV DTENARRIF NDCKDIILQ 
MNLREYNLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7YDM_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7YDM_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP48960
Sequence
>7YDM_Chain_R
SSFAILMAH YDVEDWKLT LITRVGLAL SLFCLLLCI LTFLLVRPI 
QGSRTTIHL HLCICLFVG STIFLAGIE NEGGQVGLR CRLVAGLLH 
YCFLAAFCW MSLEGLELY FLVVRVFQG QGLSTRWLC LIGYGVPLL 
IVGVSAAIY SKGYGRPRY CWLDFEQGF LWSFLGPVT FIILCNAVI 
FVTTVWKLT QKFSEINPD MKKLKKARA LTITAIAQL FLLGCTWVF 
GLFIFDDRS LVLTYVFTI LNCLQGAFL YLLHCLLNK KVREEYRKW 
ACLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YDHB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi2-G13)/&β;1/&γ;23.12023-07-1210.1016/j.chembiol.2023.08.003
7YDJB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-G12)/&β;1/&γ;23.032023-07-12To be published
7YDMB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.892023-07-1210.1016/j.chembiol.2023.08.003
7YDPB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;23.12023-07-1210.1016/j.chembiol.2023.08.003
8IKJB2AdhesionAdhesionADGRE5Homo sapiens---3.22024-02-1410.1016/j.molcel.2023.12.020
8IKLB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1L-G13)/&β;1/&γ;22.332024-01-2410.1016/j.molcel.2023.12.020




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7YDM.zip



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