Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:M68 3.8725449
2A:A:I70 5.6625448
3A:A:Y209 4.45167647
4A:A:F211 5.95448
5A:A:F218 4.92833647
6A:A:W233 12.3438859
7A:A:F234 7.302559
8A:A:E235 3.52408
9A:A:F237 3.39459
10A:A:S242 3.985408
11A:A:L246 3.97407
12A:A:F252 5.145409
13A:A:F272 4.9375409
14A:A:F289 3.44254239
15A:A:L295 3.934176
16A:A:Y308 4.422505
17A:A:F312 7.295125
18A:A:D321 4.0754125
19A:A:F330 4.6225408
20A:A:R334 4.194147
21A:A:F346 9.36405
22A:A:I366 3.9925448
23A:A:Q377 3.1365269
24B:B:L14 2.105408
25B:B:V40 4.70254153
26B:B:R48 3.47567
27B:B:H54 6.29599
28B:B:Y59 6.3525408
29B:B:W63 4.463336187
30B:B:S67 4.734185
31B:B:R68 9.88465
32B:B:W82 9.29333699
33B:B:Y85 8.548564
34B:B:N88 4.4775407
35B:B:K89 6.54599
36B:B:H91 4.975405
37B:B:I93 3.7407
38B:B:L95 3.7725408
39B:B:W99 7.13409
40B:B:Y105 3.472506
41B:B:Y111 4.62404
42B:B:C114 2.7825408
43B:B:I123 3.375476
44B:B:Y124 4.1175406
45B:B:H142 5.76167679
46B:B:Y145 11.0143758
47B:B:R150 4.6025436
48B:B:F151 3.915409
49B:B:L152 2.46403
50B:B:D163 5.942579
51B:B:T165 4.3925477
52B:B:W169 6.89667678
53B:B:I171 4.09476
54B:B:F180 6.17537
55B:B:H183 7.83439
56B:B:D186 4.9325459
57B:B:L190 3.135435
58B:B:F199 4.488539
59B:B:K209 10.7025436
60B:B:W211 7.54638
61B:B:F222 4.136518
62B:B:H225 8.76833619
63B:B:I232 5.09418
64B:B:F235 6.402867196
65B:B:F241 5.03714716
66B:B:T243 3.652518
67B:B:D247 4.478519
68B:B:R251 10.018518
69B:B:F253 5.578516
70B:B:D258 7.5075417
71B:B:Q259 2.595406
72B:B:Y264 4.341676105
73B:B:I273 3.764106
74B:B:F278 5.755407
75B:B:R283 5.885159
76B:B:Y289 6.99754107
77B:B:N295 7.464106
78B:B:H311 8.8545139
79B:B:T321 6.24754187
80B:B:S331 8.0354139
81B:B:W332 11.6585249
82B:B:K337 5.45754136
83B:B:W339 7.7845139
84G:G:L19 3.1825409
85G:G:Y40 4.3354196
86G:G:D48 5.08609
87G:G:L51 3.044156
88G:G:N59 4.706569
89G:G:F61 4.10778968
90R:R:F533 4.03833629
91R:R:M537 3.4675429
92R:R:L547 5.2375409
93R:R:L555 4.7475429
94R:R:L559 4.78754288
95R:R:L562 3.435409
96R:R:I566 3.7154229
97R:R:H583 6.6125489
98R:R:H585 10.4775489
99R:R:F597 3.63333629
100R:R:C612 4.3454299
101R:R:H620 4.70754119
102R:R:Y621 3.35406
103R:R:L624 3.995409
104R:R:W629 8.44857789
105R:R:E633 7.745489
106R:R:L637 2.874509
107R:R:F639 4.9125408
108R:R:V644 6.385449
109R:R:F645 8.43449
110R:R:Y660 6.49489
111R:R:P663 3.34609
112R:R:Y674 7.1645305
113R:R:Y678 3.945119
114R:R:R680 5.854208
115R:R:Y683 5.91754206
116R:R:W685 6.07509
117R:R:L686 5.47754119
118R:R:F692 5.8054118
119R:R:F696 2.8925409
120R:R:L697 3.44407
121R:R:F711 2.87408
122R:R:F722 7.012508
123R:R:L748 7.5225488
124R:R:T752 4.904529
125R:R:W753 4.96429729
126R:R:I759 5.85428
127R:R:Y769 5.1825219
128R:R:F771 4.45429729
129R:R:Y783 7.591676169
130R:R:E796 6.29754168
131R:R:Y797 6.694169
132R:R:W800 4.26754166
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L69 B:B:R68 40.91852.43NoYes655
2B:B:L69 B:B:Y105 41.38882.34NoYes056
3B:B:H62 B:B:Y105 51.2864.36NoYes066
4B:B:H62 B:B:R150 51.71426.77NoYes066
5B:B:L190 B:B:R150 51.86372.43YesYes356
6B:B:F199 B:B:L190 53.23882.44YesYes395
7B:B:F199 B:B:W211 53.63177.02YesYes398
8B:B:H183 B:B:W211 57.80535.29YesYes398
9B:B:A203 B:B:H183 59.62588.78NoYes389
10B:B:A203 B:B:G202 60.30011.95NoNo086
11B:B:A208 B:B:G202 60.50461.95NoNo066
12B:B:A208 B:B:F241 60.70892.77NoYes066
13B:B:F241 B:B:T243 68.18172.59YesYes168
14B:B:H225 B:B:T243 77.25715.48YesYes198
15B:B:D247 B:B:H225 84.89762.52YesYes199
16B:B:D247 B:B:S227 93.01695.89YesNo096
17B:B:D228 B:B:S227 93.19724.42NoNo096
18B:B:C204 B:B:D228 93.73659.34NoNo079
19B:B:C204 B:B:D186 46.9826.22NoYes079
20A:A:W233 B:B:D186 44.00372.23YesYes599
21A:A:F234 A:A:W233 93.50118.04YesYes599
22A:A:F234 A:A:F237 93.88042.14YesYes599
23A:A:F237 A:A:L52 93.68714.87YesNo599
24A:A:I243 A:A:L52 94.7464.28NoNo089
25A:A:I243 A:A:I286 1005.89NoNo087
26A:A:I286 A:A:R334 99.192.51NoYes077
27A:A:Q338 A:A:R334 91.46062.34NoYes1437
28A:A:P341 A:A:Q338 97.17794.74NoNo053
29A:A:P341 A:A:Y343 97.13499.74NoNo059
30A:A:D361 A:A:Y343 97.091616.09NoNo079
31A:A:D361 A:A:I287 96.96037NoNo079
32A:A:F289 A:A:I287 92.7792.51YesNo099
33A:A:F289 A:A:L246 46.16573.65YesYes097
34A:A:F64 A:A:L246 45.69023.65NoYes077
35A:A:F64 A:A:M68 91.2722.49NoYes079
36A:A:F211 A:A:M68 87.62962.49YesYes489
37A:A:F211 A:A:F218 87.36287.5YesYes487
38A:A:F218 A:A:V216 83.27473.93YesNo474
39A:A:P217 A:A:V216 84.52613.53NoNo044
40B:B:C204 B:B:M188 46.9344.86NoNo078
41A:A:W233 B:B:M188 44.00463.49YesNo598
42A:A:F289 A:A:N354 45.62262.42YesNo2399
43A:A:F64 A:A:N354 45.81094.83NoNo079
44A:A:P217 A:A:R47 84.05262.88NoNo045
45A:A:R47 R:R:G647 83.81556NoNo055
46A:A:E235 A:A:R232 10.16972.33YesNo089
47A:A:Q337 A:A:R331 13.23325.84NoNo1423
48A:A:H344 A:A:R331 12.82352.26NoNo1453
49A:A:F346 A:A:H344 12.63532.26YesNo055
50R:R:G647 R:R:Q648 83.57824.93NoNo057
51R:R:Q648 R:R:R643 83.102814.02NoNo077
52R:R:F639 R:R:R643 82.86487.48YesNo087
53R:R:F639 R:R:Y638 81.91046.19YesNo088
54R:R:I710 R:R:Y638 81.43182.42NoNo078
55R:R:I710 R:R:L637 81.19214.28NoYes079
56A:A:L374 R:R:L637 37.00632.77NoYes059
57A:A:L374 R:R:R579 36.76693.64NoNo059
58R:R:H583 R:R:R579 17.17024.51YesNo899
59R:R:F569 R:R:H583 11.97015.66NoYes099
60B:B:D258 B:B:F222 23.67664.78YesYes178
61B:B:D258 B:B:R22 20.848216.68YesNo076
62B:B:I18 B:B:R22 19.9036.26NoNo076
63B:B:I18 G:G:A23 18.95761.62NoNo078
64B:B:L14 G:G:A23 18.01191.58YesNo088
65B:B:L14 G:G:L19 15.17352.77YesYes089
66B:B:A11 G:G:L19 12.3331.58NoYes059
67B:B:A11 G:G:V16 11.38571.7NoNo057
68B:B:T321 B:B:W63 23.700910.92YesYes1877
69B:B:G324 B:B:T321 22.97653.64NoYes097
70B:B:G324 G:G:P49 22.73454.06NoNo097
71G:G:D48 G:G:P49 22.53374.83YesNo097
72B:B:K280 G:G:D48 16.63924.15NoYes019
73B:B:K280 G:G:H44 15.89296.55NoNo016
74G:G:H44 G:G:Y40 15.39422.18NoYes066
75B:B:F235 G:G:Y40 13.0913.09YesYes1966
76B:B:F235 B:B:F278 11.62448.57YesYes067
77B:B:F278 B:B:L285 10.86416.09YesNo076
78B:B:L285 B:B:Y264 10.35615.86NoYes065
79B:B:Y85 G:G:F61 33.90065.16YesYes648
80B:B:A326 G:G:F61 25.51394.16NoYes078
81B:B:G162 B:B:Y145 17.93994.35NoYes098
82B:B:G162 B:B:S161 17.63721.86NoNo099
83B:B:H142 B:B:S161 13.929413.95YesNo799
84B:B:H142 B:B:W169 10.2613.17YesYes798
85B:B:F253 B:B:R251 12.93333.21YesYes168
86R:R:G634 R:R:L637 41.90031.71NoYes099
87R:R:G634 R:R:L749 41.62971.71NoNo099
88R:R:L749 R:R:N707 40.634915.1NoNo099
89R:R:I703 R:R:N707 40.37162.83NoNo099
90R:R:F627 R:R:I703 39.86432.51NoNo099
91R:R:F627 R:R:W753 26.34064.01NoYes099
92R:R:F533 R:R:W753 11.23142YesYes299
93R:R:F627 R:R:V700 13.310913.11NoNo098
94R:R:F696 R:R:V700 13.03343.93YesNo098
95R:R:F696 R:R:W685 12.69833.01YesYes099
96R:R:F771 R:R:W753 11.23483.01YesYes299
97R:R:L748 R:R:L782 10.17972.77YesNo088
98R:R:E633 R:R:R579 19.37512.33YesNo899
99R:R:E633 R:R:I582 13.77768.2YesNo898
100R:R:I582 R:R:W629 124.7NoYes889
101B:B:R68 B:B:Y85 36.297621.61YesYes654
102B:B:A326 B:B:W63 25.28092.59NoYes077
103B:B:F222 B:B:F253 18.53542.14YesYes186
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7YDH
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRE5
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi2-G13)/Beta1/Gamma2
PDB Resolution 3.1
Date 2023-07-12
D.O.I. 10.1016/j.chembiol.2023.08.003
Net Summary
Imin 1.95
Number of Linked Nodes 832
Number of Links 976
Number of Hubs 132
Number of Links mediated by Hubs 511
Number of Communities 30
Number of Nodes involved in Communities 212
Number of Links involved in Communities 290
Path Summary
Number Of Nodes in MetaPath 104
Number Of Links MetaPath 103
Number of Shortest Paths 1188614
Length Of Smallest Path 3
Average Path Length 43.1103
Length of Longest Path 91
Minimum Path Strength 1.25
Average Path Strength 5.40059
Maximum Path Strength 33.62
Minimum Path Correlation 0.7
Average Path Correlation 0.982517
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.88679
Average % Of Corr. Nodes 33.8957
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.1642
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtQ14344
Sequence
>7YDH_Chain_A
VSAEDKAAA ERSKEIDKC LSREKTYVK RLVKILLLG ADNSGKSTF 
LKQMRIIGI HEYDFEIKN VPFKMVDVG GQRSERKRW FECFDSVTS 
ILFLVDSSD FNRLTESLN DFETIVNNR VFSNVSIIL FLNKTDLLE 
EKVQIVSIK DYFLEFEGD PHCLRDVQK FLVECFRNK RRDQQQKPL 
YHHFTTAIN TENARLIFR DVKDTILHD NLKQLMLQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7YDH_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7YDH_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP48960
Sequence
>7YDH_Chain_R
SSFAILMAH YDVEDWKLT LITRVGLAL SLFCLLLCI LTFLLVRPI 
QGSRTTIHL HLCICLFVG STIFLAGIE NEGGQVGLR CRLVAGLLH 
YCFLAAFCW MSLEGLELY FLVVRVFQG QGLSTRWLC LIGYGVPLL 
IVGVSAAIY SKGYGRPRY CWLDFEQGF LWSFLGPVT FIILCNAVI 
FVTTVWKLT QKFSEINPD MKKLKKARA LTITAIAQL FLLGCTWVF 
GLFIFDDRS LVLTYVFTI LNCLQGAFL YLLHCLLNK KVREEYRKW 
ACLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YDHB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi2-G13)/&β;1/&γ;23.12023-07-1210.1016/j.chembiol.2023.08.003
7YDJB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-G12)/&β;1/&γ;23.032023-07-12To be published
7YDMB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.892023-07-1210.1016/j.chembiol.2023.08.003
7YDPB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;23.12023-07-1210.1016/j.chembiol.2023.08.003
8IKJB2AdhesionAdhesionADGRE5Homo sapiens---3.22024-02-1410.1016/j.molcel.2023.12.020
8IKLB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1L-G13)/&β;1/&γ;22.332024-01-2410.1016/j.molcel.2023.12.020




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7YDH.zip



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