Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:M68 3.8725449
2A:A:I70 5.6625448
3A:A:Y209 4.45167647
4A:A:F211 5.95448
5A:A:F218 4.92833647
6A:A:W233 12.3438859
7A:A:F234 7.302559
8A:A:E235 3.52408
9A:A:F237 3.39459
10A:A:S242 3.985408
11A:A:L246 3.97407
12A:A:F252 5.145409
13A:A:F272 4.9375409
14A:A:F289 3.44254239
15A:A:L295 3.934176
16A:A:Y308 5.0125405
17A:A:F312 7.295105
18A:A:D321 4.0754105
19A:A:F330 4.6225408
20A:A:R334 4.194127
21A:A:F346 9.36405
22A:A:I366 3.9925448
23B:B:L14 2.105408
24B:B:V40 4.70254133
25B:B:R48 3.47567
26B:B:H54 6.29599
27B:B:Y59 6.3525408
28B:B:W63 4.463336187
29B:B:S67 4.734185
30B:B:R68 9.88465
31B:B:W82 9.29333699
32B:B:Y85 8.548564
33B:B:N88 4.4775407
34B:B:K89 6.54599
35B:B:H91 4.975405
36B:B:I93 3.7407
37B:B:L95 3.7725408
38B:B:W99 7.13409
39B:B:Y105 3.472506
40B:B:C114 2.7825408
41B:B:I123 3.375476
42B:B:Y124 4.1175406
43B:B:H142 5.76167679
44B:B:Y145 11.0143758
45B:B:R150 4.6025436
46B:B:L152 2.46403
47B:B:D163 5.942579
48B:B:T165 4.3925477
49B:B:W169 6.89667678
50B:B:I171 4.09476
51B:B:F180 6.17537
52B:B:H183 7.83439
53B:B:D186 4.9325459
54B:B:L190 3.135435
55B:B:F199 4.488539
56B:B:K209 10.7025436
57B:B:W211 7.54638
58B:B:F222 4.136518
59B:B:H225 8.76833619
60B:B:I232 5.09418
61B:B:F235 6.402867196
62B:B:F241 5.03714716
63B:B:T243 3.652518
64B:B:D247 4.478519
65B:B:R251 10.018518
66B:B:F253 5.578516
67B:B:D258 7.5075417
68B:B:Q259 2.595406
69B:B:Y264 4.341676145
70B:B:I273 3.76406
71B:B:F278 5.755407
72B:B:R283 5.885139
73B:B:Y289 6.99754147
74B:B:N295 7.464146
75B:B:H311 8.8545119
76B:B:T321 6.24754187
77B:B:S331 8.0354119
78B:B:W332 11.6585249
79B:B:K337 5.45754116
80B:B:W339 7.7845119
81G:G:L19 3.1825409
82G:G:Y40 4.3354196
83G:G:D48 5.08609
84G:G:L51 3.044136
85G:G:N59 4.706569
86G:G:F61 4.10778968
87R:R:F533 4.446529
88R:R:M537 3.4675429
89R:R:L547 5.2375409
90R:R:L555 4.7475429
91R:R:L559 4.78754278
92R:R:L562 3.435409
93R:R:I566 3.7154229
94R:R:H583 6.6125489
95R:R:H585 10.4775489
96R:R:F597 3.63333629
97R:R:C612 4.3454289
98R:R:H620 4.70754169
99R:R:Y621 3.35406
100R:R:L624 3.995409
101R:R:W629 8.44857789
102R:R:E633 7.745489
103R:R:L637 2.874509
104R:R:F639 4.9125408
105R:R:V644 6.385449
106R:R:F645 8.43449
107R:R:Y660 6.49489
108R:R:P663 3.34609
109R:R:Y674 7.1645295
110R:R:Y678 3.945169
111R:R:R680 5.854208
112R:R:Y683 5.91754206
113R:R:W685 6.07509
114R:R:L686 5.47754169
115R:R:F692 5.8054168
116R:R:F696 2.8925409
117R:R:L697 3.44407
118R:R:F711 2.87408
119R:R:F722 7.012508
120R:R:L748 7.5225488
121R:R:T752 4.904529
122R:R:W753 5.45833629
123R:R:I759 5.85428
124R:R:Y769 5.1825219
125R:R:F771 4.45429729
126R:R:Y783 7.591676159
127R:R:Y797 6.694159
128R:R:W800 4.26754156
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L69 B:B:R68 41.5022.43NoYes655
2B:B:L69 B:B:Y105 41.97792.34NoYes056
3B:B:H62 B:B:Y105 51.95284.36NoYes066
4B:B:H62 B:B:R150 52.38376.77NoYes066
5B:B:L190 B:B:R150 52.51682.43YesYes356
6B:B:F199 B:B:L190 53.90612.44YesYes395
7B:B:F199 B:B:W211 54.28557.02YesYes398
8B:B:H183 B:B:W211 58.49155.29YesYes398
9B:B:A203 B:B:H183 60.33028.78NoYes389
10B:B:A203 B:B:G202 61.01071.95NoNo086
11B:B:A208 B:B:G202 61.21591.95NoNo066
12B:B:A208 B:B:F241 61.42082.77NoYes066
13B:B:F241 B:B:T243 68.88342.59YesYes168
14B:B:H225 B:B:T243 78.04755.48YesYes198
15B:B:D247 B:B:H225 85.75822.52YesYes199
16B:B:D247 B:B:S227 93.9545.89YesNo096
17B:B:D228 B:B:S227 94.13324.42NoNo096
18B:B:C204 B:B:D228 94.66939.34NoNo079
19B:B:C204 B:B:D186 47.44956.22NoYes079
20A:A:W233 B:B:D186 44.25512.23YesYes599
21A:A:F234 A:A:W233 93.957218.04YesYes599
22A:A:F234 A:A:F237 93.92372.14YesYes599
23A:A:F237 A:A:L52 93.70314.87YesNo599
24A:A:I243 A:A:L52 94.75414.28NoNo089
25A:A:I243 A:A:I286 1005.89NoNo087
26A:A:I286 A:A:R334 98.99012.51NoYes077
27A:A:Q338 A:A:R334 91.08822.34NoYes1237
28A:A:P341 A:A:Q338 96.5124.74NoNo053
29A:A:P341 A:A:Y343 96.45989.74NoNo059
30A:A:D361 A:A:Y343 96.407416.09NoNo079
31A:A:D361 A:A:I287 96.24857NoNo079
32A:A:F289 A:A:I287 92.28222.51YesNo099
33A:A:F289 A:A:L246 45.90033.65YesYes097
34A:A:F64 A:A:L246 45.38393.65NoYes077
35A:A:F64 A:A:M68 90.63972.49NoYes079
36A:A:F211 A:A:M68 86.74462.49YesYes489
37A:A:F211 A:A:F218 86.41597.5YesYes487
38A:A:F218 A:A:V216 82.03863.93YesNo474
39A:A:P217 A:A:V216 83.10993.53NoNo044
40B:B:C204 B:B:M188 47.39814.86NoNo078
41A:A:W233 B:B:M188 44.25593.49YesNo598
42A:A:F289 A:A:N354 45.32252.42YesNo2399
43A:A:F64 A:A:N354 45.50164.83NoNo079
44A:A:P217 A:A:R47 82.59972.88NoNo045
45A:A:R47 R:R:G647 82.34426NoNo055
46A:A:E235 A:A:R232 10.55542.33YesNo089
47A:A:R232 B:B:R314 10.13282.13NoNo098
48A:A:Q337 A:A:R331 13.09585.84NoNo1223
49A:A:H344 A:A:R331 12.66992.26NoNo1253
50A:A:F346 A:A:H344 12.47422.26YesNo055
51R:R:G647 R:R:Q648 82.08844.93NoNo057
52R:R:Q648 R:R:R643 81.576114.02NoNo077
53R:R:F639 R:R:R643 81.31967.48YesNo087
54R:R:F639 R:R:Y638 80.29116.19YesNo088
55R:R:I710 R:R:Y638 79.77532.42NoNo078
56R:R:I710 R:R:L637 79.51714.28NoYes079
57A:A:L374 R:R:L637 37.0892.77NoYes059
58A:A:L374 R:R:R579 36.83673.64NoNo059
59R:R:H583 R:R:R579 18.60114.51YesNo899
60R:R:F569 R:R:H583 13.25055.66NoYes099
61B:B:D258 B:B:F222 23.96794.78YesYes178
62B:B:D258 B:B:R22 21.105516.68YesNo076
63B:B:I18 B:B:R22 20.14876.26NoNo076
64B:B:I18 G:G:A23 19.19181.62NoNo078
65B:B:L14 G:G:A23 18.23451.58YesNo088
66B:B:L14 G:G:L19 15.36142.77YesYes089
67B:B:A11 G:G:L19 12.4861.58NoYes059
68B:B:A11 G:G:V16 11.5271.7NoNo057
69B:B:T321 B:B:W63 24.076410.92YesYes1877
70B:B:G324 B:B:T321 23.34223.64NoYes097
71B:B:G324 G:G:P49 23.0974.06NoNo097
72G:G:D48 G:G:P49 22.89584.83YesNo097
73B:B:K280 G:G:D48 16.91644.15NoYes019
74B:B:K280 G:G:H44 16.15896.55NoNo016
75G:G:H44 G:G:Y40 15.65262.18NoYes066
76B:B:F235 G:G:Y40 13.31113.09YesYes1966
77B:B:F235 B:B:F278 11.82378.57YesYes067
78B:B:F278 B:B:L285 11.05126.09YesNo076
79B:B:L285 B:B:Y264 10.53495.86NoYes065
80B:B:Y85 G:G:F61 34.38895.16YesYes648
81B:B:A326 G:G:F61 25.89324.16NoYes078
82B:B:G162 B:B:Y145 18.40484.35NoYes098
83B:B:G162 B:B:S161 18.09451.86NoNo099
84B:B:H142 B:B:S161 14.290813.95YesNo799
85B:B:H142 B:B:W169 10.52933.17YesYes798
86B:B:F253 B:B:R251 13.07353.21YesYes168
87R:R:G634 R:R:L637 39.96451.71NoYes099
88R:R:G634 R:R:L749 39.67511.71NoNo099
89R:R:L749 R:R:N707 38.601315.1NoNo099
90R:R:I703 R:R:N707 38.31882.83NoNo099
91R:R:F627 R:R:I703 37.77362.51NoNo099
92R:R:F627 R:R:W753 23.35724.01NoYes099
93R:R:F771 R:R:W753 19.09593.01YesYes299
94R:R:F627 R:R:V700 14.18513.11NoNo098
95R:R:F696 R:R:V700 13.89543.93YesNo098
96R:R:F696 R:R:W685 13.62713.01YesYes099
97R:R:L748 R:R:L782 11.11252.77YesNo088
98R:R:E633 R:R:R579 18.01042.33YesNo899
99R:R:E633 R:R:I582 11.97738.2YesNo898
100B:B:R68 B:B:Y85 36.817121.61YesYes654
101B:B:A326 B:B:W63 25.65752.59NoYes077
102B:B:F222 B:B:F253 18.72622.14YesYes186
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7YDH
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRE5
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi2-G13)/Beta1/Gamma2
PDB Resolution 3.1
Date 2023-07-12
D.O.I. doi.org/10.1016/j.chembiol.2023.08.003
Net Summary
Imin 2.13
Number of Linked Nodes 830
Number of Links 967
Number of Hubs 128
Number of Links mediated by Hubs 496
Number of Communities 30
Number of Nodes involved in Communities 207
Number of Links involved in Communities 281
Path Summary
Number Of Nodes in MetaPath 103
Number Of Links MetaPath 102
Number of Shortest Paths 1122429
Length Of Smallest Path 3
Average Path Length 42.6256
Length of Longest Path 91
Minimum Path Strength 1.25
Average Path Strength 5.39755
Maximum Path Strength 33.62
Minimum Path Correlation 0.7
Average Path Correlation 0.981526
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.88679
Average % Of Corr. Nodes 34.6027
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.1875
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• response to stimulus   • immune response   • immune system process   • regulation of biological process   • signaling   • biological regulation   • cell-cell signaling   • cellular process   • cell communication   • cellular response to stimulus   • regulation of cellular process   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • cell surface receptor signaling pathway   • cell adhesion   • defense response   • response to stress   • inflammatory response   • cellular anatomical structure   • anchoring junction   • cell junction   • focal adhesion   • cell-substrate junction   • membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle
Gene OntologyCellular Component• cellular anatomical structure   • anchoring junction   • cell junction   • focal adhesion   • cell-substrate junction   • membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • cell periphery   • plasma membrane   • intracellular anatomical structure   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle membrane   • bounding membrane of organelle   • vesicle membrane   • cytoplasmic vesicle   • secretory granule   • secretory vesicle   • cytoplasm   • organelle membrane   • secretory granule membrane   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • synapse   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • signaling receptor binding   • G protein-coupled receptor binding   • D5 dopamine receptor binding   • dopamine receptor binding   • GTPase regulator activity   • enzyme regulator activity   • guanyl-nucleotide exchange factor activity   • nucleoside-triphosphatase regulator activity   • molecular function regulator activity   • G-protein beta/gamma-subunit complex binding   • G protein activity   • cation binding   • metal ion binding   • circulatory system process   • regulation of blood pressure   • regulation of biological quality   • blood circulation   • cellular developmental process   • cell differentiation   • regulation of cell motility   • regulation of fibroblast migration   • fibroblast migration   • regulation of locomotion   • ameboidal-type cell migration   • regulation of cell migration   • cell migration   • cell motility   • locomotion   • embryo development ending in birth or egg hatching   • chordate embryonic development   • embryo development   • in utero embryonic development   • regulation of developmental process   • regulation of cell shape   • cell morphogenesis   • regulation of cell morphogenesis   • anatomical structure morphogenesis   • regulation of anatomical structure morphogenesis   • regulation of body fluid levels   • wound healing   • cell activation   • hemostasis   • blood coagulation   • response to stress   • coagulation   • response to wounding   • platelet activation   • branching morphogenesis of an epithelial tube   • angiogenesis   • tube morphogenesis   • epithelial tube morphogenesis   • blood vessel development   • epithelium development   • blood vessel morphogenesis   • tube development   • morphogenesis of an epithelium   • tissue development   • vasculature development   • circulatory system development   • branching involved in blood vessel morphogenesis   • tissue morphogenesis   • morphogenesis of a branching structure   • anatomical structure formation involved in morphogenesis   • morphogenesis of a branching epithelium   • regulation of cellular component organization   • cellular component organization   • cellular component biogenesis   • cellular component assembly   • regulation of postsynapse assembly   • cell junction assembly   • regulation of synapse structure or activity   • synapse organization   • cellular component organization or biogenesis   • regulation of synapse assembly   • postsynapse organization   • postsynapse assembly   • regulation of postsynapse organization   • nervous system development   • regulation of cellular component biogenesis   • regulation of cell junction assembly   • regulation of synapse organization   • cell junction organization   • synapse assembly   • Rho-activating G protein-coupled receptor signaling pathway   • regulation of signaling   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • regulation of intracellular signal transduction   • regulation of response to stimulus   • regulation of cell communication   • Rho protein signal transduction   • pigment granule   • melanosome   • brush border membrane   • cluster of actin-based cell projections   • brush border   • apical part of cell   • plasma membrane region   • apical plasma membrane   • cell projection membrane   • postsynapse   • nucleus
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtQ14344
Sequence
>7YDH_Chain_A
VSAEDKAAA ERSKEIDKC LSREKTYVK RLVKILLLG ADNSGKSTF 
LKQMRIIGI HEYDFEIKN VPFKMVDVG GQRSERKRW FECFDSVTS 
ILFLVDSSD FNRLTESLN DFETIVNNR VFSNVSIIL FLNKTDLLE 
EKVQIVSIK DYFLEFEGD PHCLRDVQK FLVECFRNK RRDQQQKPL 
YHHFTTAIN TENARLIFR DVKDTILHD NLKQLMLQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7YDH_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7YDH_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP48960
Sequence
>7YDH_Chain_R
SSFAILMAH YDVEDWKLT LITRVGLAL SLFCLLLCI LTFLLVRPI 
QGSRTTIHL HLCICLFVG STIFLAGIE NEGGQVGLR CRLVAGLLH 
YCFLAAFCW MSLEGLELY FLVVRVFQG QGLSTRWLC LIGYGVPLL 
IVGVSAAIY SKGYGRPRY CWLDFEQGF LWSFLGPVT FIILCNAVI 
FVTTVWKLT QKFSEINPD MKKLKKARA LTITAIAQL FLLGCTWVF 
GLFIFDDRS LVLTYVFTI LNCLQGAFL YLLHCLLNK KVREEYRKW 
ACLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YDHB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi2-G13)/β1/γ23.12023-07-12doi.org/10.1016/j.chembiol.2023.08.003
7YDH (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--3.12023-07-12doi.org/10.1016/j.chembiol.2023.08.003
7YDMB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.892023-07-12doi.org/10.1016/j.chembiol.2023.08.003
7YDM (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--2.892023-07-12doi.org/10.1016/j.chembiol.2023.08.003
7YDPB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs)/β1/γ23.12023-07-12doi.org/10.1016/j.chembiol.2023.08.003
7YDP (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--3.12023-07-12doi.org/10.1016/j.chembiol.2023.08.003
8IKLB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1L-G13)/β1/γ22.332024-01-24doi.org/10.1016/j.molcel.2023.12.020
8IKL (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--2.332024-01-24doi.org/10.1016/j.molcel.2023.12.020
8IKJB2AdhesionAdhesionADGRE5Homo sapiens---3.22024-02-14doi.org/10.1016/j.molcel.2023.12.020
7YDJB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-G12)/β1/γ23.032023-07-12To be published
7YDJ (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--3.032023-07-12To be published




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