psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S531	R:R:T548	7.99	No	No	0	9	4
2	R:R:E602	R:R:S531	5.75	No	No	0	7	9
3	R:R:L547	R:R:S532	7.51	Yes	Yes	1	9	9
4	R:R:S532	R:R:T551	3.2	Yes	No	1	9	9
5	R:R:S532	R:R:T772	3.2	Yes	No	1	9	9
6	R:R:F533	R:R:L536	7.31	Yes	Yes	1	9	9
7	R:R:F533	R:R:T551	5.19	Yes	No	1	9	9
8	R:R:F533	R:R:L555	4.87	Yes	Yes	1	9	9
9	R:R:F533	R:R:F597	3.22	Yes	No	1	9	9
10	R:R:F533	R:R:F623	4.29	Yes	No	1	9	8
11	R:R:F533	R:R:W753	4.01	Yes	Yes	1	9	9
12	R:R:C776	R:R:F533	5.59	Yes	Yes	1	8	9
13	R:R:I535	R:R:Y683	13.3	No	Yes	0	8	6
14	R:R:I535	R:R:W685	3.52	No	Yes	0	8	9
15	R:R:F597	R:R:L536	4.87	No	Yes	1	9	9
16	R:R:F623	R:R:L536	9.74	No	Yes	1	8	9
17	R:R:L536	R:R:W685	7.97	Yes	Yes	1	9	9
18	R:R:F696	R:R:M537	3.73	Yes	Yes	0	9	9
19	R:R:M537	R:R:W753	4.65	Yes	Yes	1	9	9
20	R:R:G756	R:R:M537	3.49	No	Yes	1	9	9
21	R:R:F771	R:R:M537	4.98	Yes	Yes	1	9	9
22	R:R:A538	R:R:I759	3.25	No	No	0	9	8
23	R:R:H539	R:R:L693	3.86	Yes	Yes	1	6	7
24	R:R:H539	R:R:W694	6.35	Yes	No	1	6	8
25	R:R:H539	R:R:L697	3.86	Yes	No	1	6	7
26	R:R:F760	R:R:H539	15.84	No	Yes	0	8	6
27	R:R:V542	R:R:Y540	11.36	No	No	0	6	6
28	R:R:D762	R:R:Y540	6.9	No	No	0	5	6
29	R:R:D541	R:R:R680	5.96	No	Yes	0	5	8
30	R:R:D541	R:R:R682	8.34	No	No	3	5	4
31	R:R:D541	R:R:Y683	5.75	No	Yes	3	5	6
32	R:R:E543	R:R:R682	6.98	No	No	3	5	4
33	R:R:E543	R:R:Y683	3.37	No	Yes	3	5	6
34	R:R:D544	R:R:W545	3.35	Yes	No	1	8	5
35	R:R:D544	R:R:K546	12.44	Yes	No	1	8	4
36	R:R:D544	R:R:L547	4.07	Yes	Yes	1	8	9
37	R:R:D544	R:R:Y769	8.05	Yes	Yes	1	8	9
38	R:R:K546	R:R:W545	16.24	No	No	1	4	5
39	R:R:K546	R:R:Y769	8.36	No	Yes	1	4	9
40	R:R:L547	R:R:Y769	16.41	Yes	Yes	1	9	9
41	R:R:L547	R:R:T772	4.42	Yes	No	1	9	9
42	R:R:R552	R:R:T548	6.47	No	No	0	5	4
43	R:R:C776	R:R:T551	5.07	Yes	No	1	8	9
44	R:R:E602	R:R:R552	4.65	No	No	0	7	5
45	R:R:G554	R:R:V553	3.68	No	No	0	9	7
46	R:R:L555	R:R:S594	4.5	Yes	No	0	9	8
47	R:R:L555	R:R:L598	6.92	Yes	No	0	9	9
48	R:R:C776	R:R:L555	4.76	Yes	Yes	1	8	9
49	R:R:G779	R:R:S558	3.71	No	No	0	9	9
50	R:R:F591	R:R:L559	6.09	Yes	No	0	9	8
51	R:R:F560	R:R:L564	8.53	No	No	0	5	8
52	R:R:A780	R:R:C561	3.61	No	No	0	5	9
53	R:R:C561	R:R:Y783	6.72	No	Yes	0	9	9
54	R:R:F591	R:R:L562	3.65	Yes	No	0	9	9
55	R:R:G779	R:R:L562	5.13	No	No	0	9	9
56	R:R:L564	R:R:Y783	14.07	No	Yes	0	8	9
57	R:R:C565	R:R:C587	5.46	No	No	0	7	8
58	R:R:C565	R:R:Y783	4.03	No	Yes	0	7	9
59	R:R:I566	R:R:L584	4.28	No	No	0	9	9
60	R:R:C787	R:R:T568	6.76	No	No	0	9	9
61	R:R:T568	R:R:Y797	7.49	No	Yes	0	9	9
62	R:R:F569	R:R:T580	3.89	No	No	0	9	9
63	R:R:F569	R:R:H583	9.05	No	Yes	0	9	9
64	R:R:F569	R:R:L584	6.09	No	No	0	9	9
65	R:R:L570	R:R:L584	5.54	No	No	0	6	9
66	R:R:L571	R:R:W800	6.83	No	No	0	7	6
67	R:R:I575	R:R:V572	9.22	No	No	0	9	9
68	R:R:E796	R:R:V572	7.13	Yes	No	0	8	9
69	R:R:E796	R:R:P574	7.86	Yes	No	0	8	8
70	R:R:I575	R:R:T580	7.6	No	No	0	9	9
71	R:R:I575	R:R:K792	4.36	No	No	0	9	9
72	R:R:H583	R:R:R579	9.03	Yes	Yes	2	9	9
73	R:R:E636	R:R:R579	16.28	No	Yes	0	7	9
74	R:R:Q745	R:R:R579	3.5	No	Yes	2	9	9
75	R:R:L748	R:R:R579	3.64	Yes	Yes	2	8	9
76	R:R:T581	R:R:T652	4.71	No	No	0	9	6
77	R:R:I582	R:R:W629	7.05	No	Yes	0	8	9
78	R:R:E633	R:R:I582	6.83	No	No	0	9	8
79	R:R:I582	R:R:L655	5.71	No	No	0	8	7
80	R:R:E633	R:R:H583	11.08	No	Yes	2	9	9
81	R:R:H583	R:R:L748	9	Yes	Yes	2	9	8
82	R:R:H585	R:R:W629	20.1	Yes	Yes	4	9	9
83	R:R:C656	R:R:H585	4.42	No	Yes	0	4	9
84	R:R:H585	R:R:Y660	9.8	Yes	Yes	4	9	9
85	R:R:L586	R:R:L590	4.15	No	No	0	9	9
86	R:R:L586	R:R:M630	4.24	No	Yes	0	9	9
87	R:R:A625	R:R:C589	3.61	No	No	0	9	8
88	R:R:C589	R:R:Y660	4.03	No	Yes	0	8	9
89	R:R:L590	R:R:Q778	5.32	No	Yes	0	9	9
90	R:R:F591	R:R:T595	5.19	Yes	No	0	9	6
91	R:R:C622	R:R:V592	3.42	No	No	0	7	6
92	R:R:C622	R:R:G593	3.92	No	No	0	7	9
93	R:R:I596	R:R:L618	4.28	No	No	0	6	8
94	R:R:I596	R:R:L619	7.14	No	No	0	6	9
95	R:R:F597	R:R:I601	13.82	No	No	0	9	7
96	R:R:C612	R:R:N603	6.3	Yes	No	5	9	6
97	R:R:C684	R:R:N603	6.3	No	No	5	9	6
98	R:R:C612	R:R:V608	3.42	Yes	No	0	9	6
99	R:R:R613	R:R:V608	5.23	No	No	0	6	6
100	R:R:C612	R:R:C684	7.28	Yes	No	5	9	9
101	R:R:C684	R:R:V615	3.42	No	No	0	9	8
102	R:R:A616	R:R:Y678	4	No	Yes	0	9	9
103	R:R:G617	R:R:Y678	4.35	No	Yes	0	8	9
104	R:R:L619	R:R:W685	3.42	No	Yes	0	9	9
105	R:R:H620	R:R:V667	5.54	Yes	No	1	9	9
106	R:R:H620	R:R:Y678	8.71	Yes	Yes	1	9	9
107	R:R:H620	R:R:S695	5.58	Yes	No	1	9	8
108	R:R:F696	R:R:H620	5.66	Yes	Yes	0	9	9
109	R:R:Y621	R:R:Y660	4.96	No	Yes	0	6	9
110	R:R:L664	R:R:Y621	3.52	No	No	0	8	6
111	R:R:L624	R:R:P663	6.57	No	Yes	0	9	9
112	R:R:I666	R:R:L624	8.56	No	No	0	8	9
113	R:R:L624	R:R:P699	3.28	No	No	0	9	9
114	R:R:A625	R:R:P663	3.74	No	Yes	0	9	9
115	R:R:F627	R:R:M630	6.22	Yes	Yes	1	9	9
116	R:R:F627	R:R:V700	18.35	Yes	No	0	9	8
117	R:R:F627	R:R:W753	18.04	Yes	Yes	1	9	9
118	R:R:C628	R:R:V662	3.42	No	No	6	7	7
119	R:R:C628	R:R:P663	7.53	No	Yes	6	7	9
120	R:R:L632	R:R:W629	5.69	No	Yes	0	9	9
121	R:R:G659	R:R:W629	7.04	No	Yes	0	9	9
122	R:R:W629	R:R:Y660	12.54	Yes	Yes	4	9	9
123	R:R:G750	R:R:M630	3.49	No	Yes	0	9	9
124	R:R:M630	R:R:W753	3.49	Yes	Yes	1	9	9
125	R:R:M630	R:R:Q778	4.08	Yes	Yes	1	9	9
126	R:R:I703	R:R:S631	6.19	No	No	0	9	7
127	R:R:L632	R:R:L655	6.92	No	No	0	9	7
128	R:R:I658	R:R:L632	4.28	No	No	0	6	9
129	R:R:E633	R:R:L748	9.28	No	Yes	2	9	8
130	R:R:G634	R:R:N707	3.39	No	No	0	9	9
131	R:R:F639	R:R:L635	9.74	Yes	No	0	8	7
132	R:R:E636	R:R:L640	9.28	No	No	0	7	6
133	R:R:I710	R:R:L637	4.28	No	No	0	7	9
134	R:R:L637	R:R:T714	11.79	No	No	0	9	9
135	R:R:F639	R:R:Y638	5.16	Yes	No	0	8	8
136	R:R:V642	R:R:Y638	13.88	No	No	0	9	8
137	R:R:I710	R:R:Y638	4.84	No	No	0	7	8
138	R:R:F639	R:R:R643	3.21	Yes	No	0	8	7
139	R:R:F639	R:R:G649	4.52	Yes	No	0	8	7
140	R:R:T714	R:R:V641	6.35	No	No	0	9	9
141	R:R:Q648	R:R:R643	25.7	No	No	0	7	7
142	R:R:S651	R:R:W654	3.71	No	Yes	0	6	6
143	R:R:R653	R:R:W654	4	No	Yes	0	5	6
144	R:R:G659	R:R:I658	3.53	No	No	0	9	6
145	R:R:P663	R:R:V662	3.53	Yes	No	6	9	7
146	R:R:V667	R:R:Y678	3.79	No	Yes	1	9	9
147	R:R:F692	R:R:S670	5.28	Yes	No	1	8	9
148	R:R:S670	R:R:S695	4.89	No	No	1	9	8
149	R:R:K676	R:R:Y674	5.97	No	Yes	0	3	5
150	R:R:Q690	R:R:Y674	7.89	No	Yes	0	2	5
151	R:R:F692	R:R:Y674	7.22	Yes	Yes	0	8	5
152	R:R:F692	R:R:G677	4.52	Yes	No	0	8	8
153	R:R:F692	R:R:Y678	10.32	Yes	Yes	1	8	9
154	R:R:D687	R:R:R680	5.96	No	Yes	0	5	8
155	R:R:F688	R:R:R680	8.55	No	Yes	0	4	8
156	R:R:R682	R:R:Y683	18.52	No	Yes	3	4	6
157	R:R:L686	R:R:W685	18.22	No	Yes	1	9	9
158	R:R:L693	R:R:W685	4.56	Yes	Yes	1	7	9
159	R:R:F696	R:R:W685	13.03	Yes	Yes	0	9	9
160	R:R:F692	R:R:L686	6.09	Yes	No	1	8	9
161	R:R:L686	R:R:L693	4.15	No	Yes	1	9	7
162	R:R:D687	R:R:E689	6.5	No	No	0	5	3
163	R:R:F692	R:R:S695	7.93	Yes	No	1	8	8
164	R:R:L693	R:R:L697	6.92	Yes	No	1	7	7
165	R:R:L697	R:R:W694	14.81	No	No	1	7	8
166	R:R:F696	R:R:V700	5.24	Yes	No	0	9	8
167	R:R:G698	R:R:P699	4.06	No	No	0	8	9
168	R:R:G698	R:R:T701	3.64	No	No	0	8	7
169	R:R:L757	R:R:T701	5.9	No	No	0	5	7
170	R:R:C706	R:R:F702	8.38	No	No	0	5	4
171	R:R:L749	R:R:N707	15.1	No	No	0	9	9
172	R:R:F711	R:R:V715	7.87	Yes	No	0	8	6
173	R:R:F711	R:R:L746	15.83	Yes	No	0	8	7
174	R:R:F711	R:R:L749	3.65	Yes	No	0	8	9
175	R:R:K717	R:R:W716	8.12	No	No	0	8	8
176	R:R:Q720	R:R:W716	7.67	No	No	0	5	8
177	R:R:L738	R:R:T719	4.42	No	No	0	9	8
178	R:R:E724	R:R:K721	9.45	No	No	0	8	9
179	R:R:F722	R:R:N726	9.67	No	Yes	7	8	8
180	R:R:F722	R:R:M729	8.71	No	Yes	7	8	7
181	R:R:F722	R:R:K734	14.89	No	No	0	8	7
182	R:R:I725	R:R:N726	5.66	No	Yes	0	8	8
183	R:R:M729	R:R:N726	4.21	Yes	Yes	7	7	8
184	R:R:K733	R:R:M729	5.76	No	Yes	0	5	7
185	R:R:A737	R:R:M729	3.22	No	Yes	0	6	7
186	R:R:K730	R:R:K733	7.18	No	No	0	8	5
187	R:R:K734	R:R:L738	5.64	No	No	0	7	9
188	R:R:A744	R:R:L785	6.3	No	No	0	9	8
189	R:R:L748	R:R:Q745	3.99	Yes	No	2	8	9
190	R:R:F747	R:R:T752	5.19	No	No	0	5	9
191	R:R:F747	R:R:F781	16.08	No	No	0	5	8
192	R:R:H786	R:R:L748	11.57	No	Yes	0	9	8
193	R:R:N775	R:R:T752	5.85	No	No	0	9	9
194	R:R:F771	R:R:W753	8.02	Yes	Yes	1	9	9
195	R:R:N775	R:R:W753	15.82	No	Yes	1	9	9
196	R:R:Q778	R:R:W753	8.76	Yes	Yes	1	9	9
197	R:R:F755	R:R:V754	3.93	Yes	No	0	8	6
198	R:R:F755	R:R:L767	3.65	Yes	No	0	8	7
199	R:R:F755	R:R:V770	9.18	Yes	No	0	8	6
200	R:R:F755	R:R:L774	3.65	Yes	No	0	8	7
201	R:R:G756	R:R:I759	3.53	No	No	0	9	8
202	R:R:F771	R:R:G756	6.02	Yes	No	1	9	9
203	R:R:F758	R:R:L767	3.65	No	No	0	8	7
204	R:R:I759	R:R:T768	7.6	No	No	0	8	7
205	R:R:D761	R:R:D762	3.99	No	No	0	4	5
206	R:R:D761	R:R:R763	10.72	No	No	0	4	4
207	R:R:F771	R:R:N775	18.12	Yes	No	1	9	9
208	R:R:F781	R:R:L777	3.65	No	No	0	8	8
209	R:R:L782	R:R:Q778	3.99	No	Yes	0	8	9
210	R:R:H786	R:R:L782	3.86	No	No	0	9	8
211	R:R:C787	R:R:Y783	6.72	No	Yes	0	9	9
212	R:R:L788	R:R:Y783	9.38	No	Yes	0	8	9
213	R:R:Y783	R:R:Y797	4.96	Yes	Yes	0	9	9
214	R:R:L784	R:R:L788	4.15	No	No	0	5	8
215	R:R:N790	R:R:V793	5.91	No	No	0	9	9
216	R:R:E795	R:R:K791	4.05	No	No	0	6	8
217	R:R:V793	R:R:Y797	7.57	No	Yes	0	9	9
218	R:R:E796	R:R:W800	4.36	Yes	No	0	8	6
219	R:R:W800	R:R:Y797	4.82	No	Yes	0	6	9
220	R:R:C561	R:R:L557	3.17	No	No	0	9	6
221	R:R:C587	R:R:L562	3.17	No	No	0	8	9
222	R:R:C751	R:R:L746	3.17	No	No	0	5	7
223	R:R:A626	R:R:L590	3.15	No	No	0	8	9
224	R:R:I596	R:R:V592	3.07	No	No	0	6	6
225	R:R:I704	R:R:V700	3.07	No	No	0	6	8
226	R:R:I704	R:R:V754	3.07	No	No	0	6	6
227	R:R:K717	R:R:T713	3	No	No	0	8	6
228	R:R:L718	R:R:T741	2.95	No	No	0	8	9
229	R:R:I566	R:R:I588	2.94	No	No	0	9	7
230	R:R:A744	R:R:H786	2.93	No	No	0	9	9
231	R:R:P681	R:R:R680	2.88	No	Yes	0	3	8
232	R:R:Q576	R:R:T580	2.83	No	No	0	8	9
233	R:R:I703	R:R:N707	2.83	No	No	0	9	9
234	R:R:L610	R:R:L614	2.77	No	No	0	6	5
235	R:R:L637	R:R:L749	2.77	No	No	0	9	9
236	R:R:L650	R:R:L655	2.77	No	No	0	5	7
237	R:R:A742	R:R:F711	2.77	No	Yes	0	9	8
238	R:R:L718	R:R:L738	2.77	No	No	0	8	9
239	R:R:L784	R:R:L789	2.77	No	No	0	5	8
240	R:R:H585	R:R:T581	2.74	Yes	No	0	9	9
241	R:R:R611	R:R:V615	2.62	No	No	0	7	8
242	R:R:S531	R:R:Y683	2.54	No	Yes	0	9	6
243	R:R:F627	R:R:I703	2.51	Yes	No	0	9	9
244	R:R:F747	R:R:I743	2.51	No	No	0	5	6
245	R:R:F591	R:R:L563	2.44	Yes	No	0	9	5
246	R:R:I550	R:R:Y769	2.42	No	Yes	0	8	9
247	R:R:L765	R:R:Y769	2.34	No	Yes	0	3	9
248	R:R:E795	R:R:R798	2.33	No	No	0	6	4
249	R:R:L650	R:R:W654	2.28	No	Yes	0	5	6
250	R:R:L657	R:R:W654	2.28	No	Yes	0	7	6
251	R:R:G605	R:R:G606	2.11	No	No	0	7	6
252	R:R:R613	R:R:Y678	2.06	No	Yes	0	6	9
253	R:R:G606	R:R:P681	2.03	No	No	0	6	3
254	R:R:G661	R:R:P663	2.03	No	Yes	0	9	9
255	R:R:C776	R:R:G554	1.96	Yes	No	0	8	9
256	R:R:C612	R:R:G679	1.96	Yes	No	0	9	9
257	R:R:A599	R:R:G600	1.95	No	No	0	6	8
258	R:R:A708	R:R:C751	1.81	No	No	0	6	5
259	R:R:A534	R:R:S532	1.71	No	Yes	0	9	9
260	R:R:A671	R:R:S675	1.71	No	No	0	8	6
261	R:R:A538	R:R:V542	1.7	No	No	0	9	6
262	R:R:G647	R:R:Q646	1.64	No	No	0	5	7
263	R:R:N726	R:R:P727	1.63	Yes	No	0	8	6
264	R:R:D728	R:R:P727	1.61	No	No	0	8	6
265	R:R:T713	R:R:V642	1.59	No	No	0	6	9
266	R:R:T719	R:R:V715	1.59	No	No	0	8	6
267	R:R:I673	R:R:V669	1.54	No	No	0	5	7
268	R:R:I743	R:R:T739	1.52	No	No	0	6	9
269	R:R:G600	R:R:R611	1.5	No	No	0	8	7
270	R:R:L767	R:R:S764	1.5	No	No	0	7	7
271	R:R:L549	R:R:V553	1.49	No	No	0	5	7
272	R:R:I550	R:R:I773	1.47	No	No	0	8	8
273	R:R:L705	R:R:T701	1.47	No	No	0	5	7
274	R:R:I725	R:R:K721	1.45	No	No	0	8	9
275	R:R:P574	R:R:R573	1.44	No	No	0	8	8
276	R:R:E636	R:R:S578	1.44	No	No	0	7	8
277	R:R:E724	R:R:S723	1.44	No	No	0	8	8
278	R:R:I740	R:R:L785	1.43	No	No	0	7	8
279	R:R:I740	R:R:L789	1.43	No	No	0	7	8
280	R:R:G691	R:R:W694	1.41	No	No	0	6	8
281	R:R:E796	R:R:K799	1.35	Yes	No	0	8	5
282	R:R:A671	R:R:Y678	1.33	No	Yes	0	8	9
283	R:R:K791	R:R:R794	1.24	No	No	0	8	8
284	R:R:I673	R:R:Y674	1.21	No	Yes	0	5	5
285	R:R:F645	R:R:Q648	1.17	No	No	0	9	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S532	3.905	4	1	9
2	R:R:F533	4.92571	7	1	9
3	R:R:L536	7.4725	4	1	9
4	R:R:M537	4.2125	4	1	9
5	R:R:H539	7.4775	4	1	6
6	R:R:D544	6.9775	4	1	8
7	R:R:L547	8.1025	4	1	9
8	R:R:L555	5.2625	4	1	9
9	R:R:R579	8.1125	4	2	9
10	R:R:H583	9.54	4	2	9
11	R:R:H585	9.265	4	4	9
12	R:R:F591	4.3425	4	0	9
13	R:R:C612	4.74	4	5	9
14	R:R:H620	6.3725	4	1	9
15	R:R:F627	11.28	4	1	9
16	R:R:W629	10.484	5	4	9
17	R:R:M630	4.304	5	1	9
18	R:R:F639	5.6575	4	0	8
19	R:R:W654	3.0675	4	0	6
20	R:R:Y660	7.8325	4	4	9
21	R:R:P663	4.68	5	6	9
22	R:R:Y674	5.5725	4	0	5
23	R:R:Y678	4.93714	7	1	9
24	R:R:R680	5.8375	4	0	8
25	R:R:Y683	8.696	5	3	6
26	R:R:W685	8.45333	6	1	9
27	R:R:F692	6.89333	6	1	8
28	R:R:L693	4.8725	4	1	7
29	R:R:F696	6.915	4	0	9
30	R:R:F711	7.53	4	0	8
31	R:R:N726	5.2925	4	7	8
32	R:R:M729	5.475	4	7	7
33	R:R:L748	7.496	5	2	8
34	R:R:W753	8.97	7	1	9
35	R:R:F755	5.1025	4	0	8
36	R:R:Y769	7.516	5	1	9
37	R:R:F771	9.285	4	1	9
38	R:R:C776	4.345	4	1	8
39	R:R:Q778	5.5375	4	1	9
40	R:R:Y783	7.64667	6	0	9
41	R:R:E796	5.175	4	0	8
42	R:R:Y797	6.21	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L547	R:R:S532	10.6643	7.51	Yes	Yes	1	9	9
2	R:R:S532	R:R:T551	14.1217	3.2	Yes	No	1	9	9
3	R:R:F533	R:R:T551	14.8708	5.19	Yes	No	1	9	9
4	R:R:F533	R:R:L536	23.7529	7.31	Yes	Yes	1	9	9
5	R:R:L536	R:R:W685	24.3291	7.97	Yes	Yes	1	9	9
6	R:R:I535	R:R:W685	25.0535	3.52	No	Yes	0	8	9
7	R:R:I535	R:R:Y683	23.6953	13.3	No	Yes	0	8	6
8	R:R:F533	R:R:W753	35.8578	4.01	Yes	Yes	1	9	9
9	R:R:F696	R:R:W685	32.8202	13.03	Yes	Yes	0	9	9
10	R:R:F696	R:R:M537	38.0145	3.73	Yes	Yes	0	9	9
11	R:R:M537	R:R:W753	38.8336	4.65	Yes	Yes	1	9	9
12	R:R:A538	R:R:I759	10.4667	3.25	No	No	0	9	8
13	R:R:G756	R:R:I759	13.8912	3.53	No	No	0	9	8
14	R:R:L693	R:R:W685	10.6767	4.56	Yes	Yes	1	7	9
15	R:R:D541	R:R:Y683	12.0102	5.75	No	Yes	3	5	6
16	R:R:D541	R:R:R680	10.5779	5.96	No	Yes	0	5	8
17	R:R:C587	R:R:L562	11.5492	3.17	No	No	0	8	9
18	R:R:C565	R:R:C587	13.1668	5.46	No	No	0	7	8
19	R:R:C565	R:R:Y783	14.7761	4.03	No	Yes	0	7	9
20	R:R:L788	R:R:Y783	27.6342	9.38	No	Yes	0	8	9
21	R:R:L784	R:R:L788	28.8689	4.15	No	No	0	5	8
22	R:R:L784	R:R:L789	30.112	2.77	No	No	0	5	8
23	R:R:I740	R:R:L789	31.3591	1.43	No	No	0	7	8
24	R:R:I740	R:R:L785	32.5198	1.43	No	No	0	7	8
25	R:R:A744	R:R:L785	33.7792	6.3	No	No	0	9	8
26	R:R:A744	R:R:H786	35.0798	2.93	No	No	0	9	9
27	R:R:H786	R:R:L782	99.1933	3.86	No	No	0	9	8
28	R:R:L782	R:R:Q778	100	3.99	No	Yes	0	8	9
29	R:R:Q778	R:R:W753	81.1039	8.76	Yes	Yes	1	9	9
30	R:R:F569	R:R:H583	25.07	9.05	No	Yes	0	9	9
31	R:R:H583	R:R:L748	20.135	9	Yes	Yes	2	9	8
32	R:R:H786	R:R:L748	71.0611	11.57	No	Yes	0	9	8
33	R:R:F569	R:R:T580	18.9167	3.89	No	No	0	9	9
34	R:R:E796	R:R:V572	12.607	7.13	Yes	No	0	8	9
35	R:R:I575	R:R:V572	13.8953	9.22	No	No	0	9	9
36	R:R:I575	R:R:T580	16.4142	7.6	No	No	0	9	9
37	R:R:E633	R:R:L748	44.6205	9.28	No	Yes	2	9	8
38	R:R:E633	R:R:I582	49.3291	6.83	No	No	0	9	8
39	R:R:I582	R:R:W629	36.9444	7.05	No	Yes	0	8	9
40	R:R:I582	R:R:L655	12.1419	5.71	No	No	0	8	7
41	R:R:W629	R:R:Y660	24.4526	12.54	Yes	Yes	4	9	9
42	R:R:F627	R:R:M630	21.8061	6.22	Yes	Yes	1	9	9
43	R:R:F627	R:R:V700	24.1851	18.35	Yes	No	0	9	8
44	R:R:F696	R:R:V700	17.6984	5.24	Yes	No	0	9	8
45	R:R:A625	R:R:C589	18.8138	3.61	No	No	0	9	8
46	R:R:C589	R:R:Y660	20.3284	4.03	No	Yes	0	8	9
47	R:R:C612	R:R:V608	10.6643	3.42	Yes	No	0	9	6
48	R:R:R613	R:R:V608	11.9608	5.23	No	No	0	6	6
49	R:R:R613	R:R:Y678	13.2491	2.06	No	Yes	0	6	9
50	R:R:H620	R:R:Y678	20.3861	8.71	Yes	Yes	1	9	9
51	R:R:F696	R:R:H620	29.0583	5.66	Yes	Yes	0	9	9
52	R:R:F692	R:R:L686	13.7759	6.09	Yes	No	1	8	9
53	R:R:L686	R:R:W685	14.1958	18.22	No	Yes	1	9	9
54	R:R:L624	R:R:P663	11.1171	6.57	No	Yes	0	9	9
55	R:R:A625	R:R:P663	17.2909	3.74	No	Yes	0	9	9
56	R:R:F627	R:R:I703	57.5938	2.51	Yes	No	0	9	9
57	R:R:I703	R:R:N707	55.2889	2.83	No	No	0	9	9
58	R:R:I710	R:R:Y638	17.2251	4.84	No	No	0	7	8
59	R:R:I710	R:R:L637	18.6286	4.28	No	No	0	7	9
60	R:R:L637	R:R:L749	22.5593	2.77	No	No	0	9	9
61	R:R:L749	R:R:N707	52.9511	15.1	No	No	0	9	9
62	R:R:F692	R:R:Y674	14.6485	7.22	Yes	Yes	0	8	5
63	R:R:F711	R:R:L749	32.1576	3.65	Yes	No	0	8	9
64	R:R:F711	R:R:V715	25.5598	7.87	Yes	No	0	8	6
65	R:R:L738	R:R:T719	22.8186	4.42	No	No	0	9	8
66	R:R:T719	R:R:V715	24.1974	1.59	No	No	0	8	6
67	R:R:F722	R:R:N726	10.2239	9.67	No	Yes	7	8	8
68	R:R:F722	R:R:K734	17.4679	14.89	No	No	0	8	7
69	R:R:K734	R:R:L738	18.8755	5.64	No	No	0	7	9
70	R:R:I704	R:R:V754	10.1951	3.07	No	No	0	6	6
71	R:R:I704	R:R:V700	11.6192	3.07	No	No	0	6	8
72	R:R:F627	R:R:W753	30.7129	18.04	Yes	Yes	1	9	9
73	R:R:M630	R:R:Q778	20.8841	4.08	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8IKL_nogp

PDB Summary
PDB	8IKL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.2
Number of Linked Nodes	253
Number of Links	285
Number of Hubs	42
Number of Links mediated by Hubs	155
Number of Communities	7
Number of Nodes involved in Communities	55
Number of Links involved in Communities	76

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	46423
Length Of Smallest Path	3
Average Path Length	14.2691
Length of Longest Path	32
Minimum Path Strength	1.375
Average Path Strength	6.41955
Maximum Path Strength	18.195
Minimum Path Correlation	0.7
Average Path Correlation	0.930934
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	52.2326
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.8029
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• response to stimulus • immune response • immune system process • regulation of biological process • signaling • biological regulation • cell-cell signaling • cellular process • cell communication • cellular response to stimulus • regulation of cellular process • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell surface receptor signaling pathway • cell adhesion • defense response • response to stress • inflammatory response • cellular anatomical structure • anchoring junction • cell junction • focal adhesion • cell-substrate junction • membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle
Gene Ontology	Cellular Component	• cellular anatomical structure • anchoring junction • cell junction • focal adhesion • cell-substrate junction • membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cell periphery • plasma membrane • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • organelle membrane • secretory granule membrane • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • GDP binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • D5 dopamine receptor binding • dopamine receptor binding • GTPase regulator activity • enzyme regulator activity • guanyl-nucleotide exchange factor activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • G protein activity • cellular process • cell division • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • positive regulation of autophagy • catabolic process • macroautophagy • autophagy • positive regulation of biological process • regulation of catabolic process • regulation of autophagy • positive regulation of catabolic process • positive regulation of metabolic process • regulation of macroautophagy • metabolic process • positive regulation of macroautophagy • process utilizing autophagic mechanism • regulation of metabolic process • positive regulation of cellular process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • nucleoside phosphate metabolic process • ribose phosphate metabolic process • purine nucleoside triphosphate metabolic process • GTP metabolic process • carbohydrate derivative metabolic process • primary metabolic process • nucleotide metabolic process • purine-containing compound metabolic process • nucleobase-containing compound metabolic process • purine nucleotide metabolic process • ribonucleotide metabolic process • organophosphate metabolic process • nucleobase-containing small molecule metabolic process • purine ribonucleoside triphosphate metabolic process • phosphate-containing compound metabolic process • small molecule metabolic process • nucleoside triphosphate metabolic process • purine ribonucleotide metabolic process • phosphorus metabolic process • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • regulation of biological quality • blood circulation • developmental process • cellular developmental process • cell differentiation • regulation of cell motility • regulation of fibroblast migration • fibroblast migration • regulation of locomotion • ameboidal-type cell migration • regulation of cell migration • cell migration • cell motility • locomotion • multicellular organism development • embryo development ending in birth or egg hatching • chordate embryonic development • anatomical structure development • embryo development • in utero embryonic development • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of developmental process • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • branching morphogenesis of an epithelial tube • angiogenesis • tube morphogenesis • epithelial tube morphogenesis • blood vessel development • system development • epithelium development • blood vessel morphogenesis • tube development • morphogenesis of an epithelium • tissue development • vasculature development • circulatory system development • branching involved in blood vessel morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • anatomical structure formation involved in morphogenesis • morphogenesis of a branching epithelium • regulation of cellular component organization • cellular component organization • cellular component biogenesis • cellular component assembly • regulation of postsynapse assembly • cell junction assembly • regulation of synapse structure or activity • synapse organization • cellular component organization or biogenesis • regulation of synapse assembly • postsynapse organization • postsynapse assembly • regulation of postsynapse organization • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • Rho-activating G protein-coupled receptor signaling pathway • regulation of signaling • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • regulation of signal transduction • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • intracellular signaling cassette • regulation of cell communication • Rho protein signal transduction • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • pigment granule • melanosome • brush border membrane • cluster of actin-based cell projections • brush border • apical part of cell • plasma membrane region • apical plasma membrane • cell projection membrane • postsynapse • synapse • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P48960
Sequence	>8IKL_nogp_Chain_R S S F A I L M A H Y D V E D W K L T L I T R V G L A L S L F C L L L C I L T F L L V R P I Q G S R T T I H L H L C I C L F V G S T I F L A G I E N E G G Q V G L R C R L V A G L L H Y C F L A A F C W M S L E G L E L Y F L V V R V F Q G Q G L S T R W L C L I G Y G V P L L I V G V S A A I Y S K G Y G R P R Y C W L D F E Q G F L W S F L G P V T F I I L C N A V I F V T T V W K L T Q K F S E I N P D M K K L K K A R A L T I T A I A Q L F L L G C T W V F G L F I F D D R S L V L T Y V F T I L N C L Q G A F L Y L L H C L L N K K V R E E Y R K W A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YDH	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi2-G13)/β1/γ2	3.1	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	7YDH (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		3.1	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	7YDM	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.89	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	7YDM (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		2.89	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	7YDP	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	7YDP (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		3.1	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	8IKL	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi1L-G13)/β1/γ2	2.33	2024-01-24	doi.org/10.1016/j.molcel.2023.12.020
	8IKL (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		2.33	2024-01-24	doi.org/10.1016/j.molcel.2023.12.020
	8IKJ	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	-	3.2	2024-02-14	doi.org/10.1016/j.molcel.2023.12.020
	7YDJ	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi1-G12)/β1/γ2	3.03	2023-07-12	To be published
	7YDJ (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		3.03	2023-07-12	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8IKL_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.