Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L53 4.704529
2A:A:N58 8.0125109
3A:A:F64 5.655427
4A:A:Y209 8.2025407
5A:A:F211 6.7775428
6A:A:I213 5.5225425
7A:A:P217 6.635404
8A:A:F218 6.02167627
9A:A:K219 6.97476
10A:A:R227 5.88254149
11A:A:W233 9.0775409
12A:A:F237 8.4675479
13A:A:S242 4.792528
14A:A:I243 6.2225478
15A:A:L244 4.6675428
16A:A:F245 6.0475409
17A:A:L246 4.218527
18A:A:D248 9.654108
19A:A:S250 4.514109
20A:A:R264 10.174109
21A:A:F272 9.5409
22A:A:F281 5.7479
23A:A:I286 4.2775407
24A:A:F289 5.555829
25A:A:L290 6.0925409
26A:A:F309 7.31254199
27A:A:F312 7.474505
28A:A:F325 9.694196
29A:A:F330 10.1275408
30A:A:K340 7.022527
31A:A:Y343 9.124529
32A:A:F346 10.2485205
33A:A:N351 4.515429
34A:A:N354 8.555429
35A:A:F359 7.58429
36A:A:V362 3.294528
37A:A:T365 5.156526
38A:A:I366 3.2825408
39A:A:L376 3.70754228
40B:B:L7 2.542508
41B:B:L30 4.705405
42B:B:V40 5.38443
43B:B:H54 9.28667639
44B:B:L55 5.24406
45B:B:M61 4.8975436
46B:B:W63 5.67333637
47B:B:D76 7.0075439
48B:B:I81 4.9254137
49B:B:W82 10.0771739
50B:B:N88 5.5575407
51B:B:K89 7.16639
52B:B:H91 6.2485135
53B:B:I93 4.6625407
54B:B:L95 4.41254158
55B:B:W99 9.51779
56B:B:M101 5.49409
57B:B:Y105 4.362506
58B:B:N110 6.53754164
59B:B:Y111 7.27754164
60B:B:L117 5.165479
61B:B:I120 3.2475406
62B:B:C121 4.135488
63B:B:I123 4.025406
64B:B:Y124 5.211676156
65B:B:L139 8.6925409
66B:B:H142 7.354589
67B:B:Y145 6.406588
68B:B:F151 5.11667609
69B:B:L152 5.8975403
70B:B:I157 5407
71B:B:T159 6.0875489
72B:B:D163 7.454589
73B:B:C166 4.235498
74B:B:W169 9.38667688
75B:B:Q176 6.548584
76B:B:F180 8.82597
77B:B:H183 8.385699
78B:B:V187 4.426599
79B:B:F199 8.9075499
80B:B:S201 5.2625499
81B:B:D205 6.578599
82B:B:K209 11.975496
83B:B:W211 8.64167698
84B:B:Q220 7.645457
85B:B:F222 9.4625458
86B:B:H225 9.63667659
87B:B:I232 5.4775458
88B:B:F234 7.125455
89B:B:F235 7.60857746
90B:B:P236 6.3775447
91B:B:F241 7.295656
92B:B:T243 5.67458
93B:B:D247 7.9175459
94B:B:R251 12.13558
95B:B:F253 7.968556
96B:B:D258 10.0575457
97B:B:Q259 5.084246
98B:B:M262 4.9075404
99B:B:Y264 6.312545
100B:B:I269 3.906544
101B:B:R283 7.24333649
102B:B:L284 5.1405
103B:B:L285 5.178546
104B:B:Y289 7.56571747
105B:B:N295 8.028546
106B:B:V296 3.915405
107B:B:W297 6.465448
108B:B:H311 9.628569
109B:B:W332 15.1785189
110B:B:D333 8.135469
111B:B:K337 8.344566
112B:B:W339 9.826569
113B:B:N340 7.75569
114G:G:L19 3.8754239
115G:G:R27 5.352508
116G:G:Y40 10.4725446
117G:G:D48 5.866509
118G:G:P49 5.2025437
119G:G:L51 3.468506
120G:G:V54 4.33436
121G:G:F61 5.71857768
122R:R:S532 3.905419
123R:R:F533 4.92571719
124R:R:L536 7.4725419
125R:R:M537 4.2125419
126R:R:H539 7.4775416
127R:R:D544 6.9775418
128R:R:L547 8.1025419
129R:R:T551 4.15419
130R:R:L555 5.2625419
131R:R:I575 6.0625409
132R:R:R579 8.11254119
133R:R:H583 9.544119
134R:R:H585 9.2654289
135R:R:F591 4.3425409
136R:R:C612 4.744299
137R:R:H620 5.732519
138R:R:W629 10.4845289
139R:R:M630 4.304519
140R:R:L637 5.4025409
141R:R:F639 5.6575408
142R:R:L640 5.4075406
143R:R:W654 3.0675406
144R:R:Y660 7.83254289
145R:R:P663 4.685309
146R:R:Y674 5.5725405
147R:R:Y678 4.93714719
148R:R:R680 5.2885128
149R:R:Y683 7.761676126
150R:R:W685 7.69857719
151R:R:F692 6.89333618
152R:R:L693 4.8725417
153R:R:F696 6.915419
154R:R:F711 7.53408
155R:R:F722 9.56254218
156R:R:I725 5.92408
157R:R:N726 5.29254218
158R:R:M729 5.4754217
159R:R:L748 7.4965118
160R:R:W753 8.97719
161R:R:F755 5.1025408
162R:R:Y769 7.516519
163R:R:F771 9.285419
164R:R:C776 4.345418
165R:R:Q778 5.5375419
166R:R:Y783 7.64667609
167R:R:L789 2.40754228
168R:R:V793 4.934279
169R:R:E796 5.175408
170R:R:Y797 6.214279
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:K89 B:B:W82 10.24969.28YesYes399
2B:B:L70 B:B:W82 13.59986.83NoYes359
3B:B:L70 B:B:M61 12.61468.48NoYes356
4B:B:C317 B:B:M61 29.98813.24NoYes076
5B:B:C317 B:B:S316 30.15063.44NoNo079
6B:B:S316 B:B:W332 30.31484.94NoYes099
7B:B:W332 B:B:Y59 65.86957.72YesNo1898
8B:B:Q75 B:B:Y59 66.326.76NoNo098
9B:B:Q75 B:B:W99 66.44620.81NoYes099
10A:A:E208 B:B:W99 99.67177.63NoYes799
11A:A:E208 A:A:K219 1005.4NoYes796
12A:A:K219 A:A:L48 49.96569.87YesNo766
13A:A:L48 A:A:Y44 50.09553.52NoNo062
14A:A:D210 A:A:K219 49.96588.3NoYes036
15A:A:D210 A:A:Y44 49.96444.6NoNo032
16A:A:P217 A:A:Y44 99.99148.34YesNo042
17A:A:F218 A:A:V216 93.86446.55YesNo074
18A:A:P217 A:A:V216 99.57693.53YesNo044
19A:A:F218 A:A:V362 88.5263.93YesYes278
20A:A:F237 B:B:W99 28.81489.02YesYes799
21A:A:F237 A:A:L52 30.126312.18YesNo799
22A:A:I243 A:A:L52 29.4497.14YesNo789
23A:A:S242 A:A:V362 10.63043.23YesYes288
24A:A:I243 A:A:I286 31.36585.89YesYes087
25A:A:I286 A:A:V276 15.79754.61YesNo076
26A:A:F272 A:A:V276 14.830214.42YesNo096
27A:A:I286 A:A:R334 15.19763.76YesNo077
28A:A:F272 A:A:R334 14.81073.21YesNo097
29A:A:F312 A:A:I305 10.54618.79YesNo056
30A:A:F312 A:A:F325 14.972218.22YesYes056
31A:A:C329 A:A:F325 17.37758.38NoYes056
32A:A:C329 A:A:L269 17.77773.17NoNo056
33A:A:F330 A:A:L269 18.177812.18YesNo086
34A:A:F272 A:A:F330 24.495610.72YesYes098
35B:B:G162 B:B:S161 31.2283.71NoNo899
36B:B:G162 B:B:Y145 31.27434.35NoYes898
37B:B:M101 B:B:Y145 27.62234.79YesYes098
38A:A:C236 B:B:M101 28.3483.24NoYes099
39A:A:C236 B:B:W99 28.42743.92NoYes799
40B:B:R314 B:B:W332 37.683323.99NoYes089
41A:A:I366 A:A:V362 84.81963.07YesYes088
42A:A:I366 A:A:N370 85.0744.25YesNo088
43A:A:N370 R:R:L640 84.97786.87NoYes086
44A:A:L374 R:R:L640 39.90264.15NoYes056
45A:A:L374 R:R:Q745 36.66523.99NoNo059
46B:B:D290 B:B:R314 36.900914.29NoNo068
47B:B:C271 B:B:D290 36.59534.67NoNo056
48B:B:C271 B:B:Y289 35.74044.03NoYes457
49B:B:W297 B:B:Y289 26.67715.79YesYes487
50B:B:W297 B:B:Y264 26.61548.68YesYes485
51B:B:L252 B:B:Y264 16.16447.03NoYes075
52B:B:L252 B:B:L261 15.99582.77NoNo075
53B:B:D254 B:B:L261 17.50635.43NoNo095
54B:B:A257 B:B:D254 17.13284.63NoNo079
55B:B:A257 B:B:Q259 16.94573.03NoYes076
56B:B:Q259 B:B:R22 15.81977.01YesNo066
57B:B:T321 B:B:W63 10.310110.92NoYes377
58B:B:D258 B:B:R22 10.645814.29YesNo076
59B:B:H142 B:B:S161 29.251816.74YesNo899
60B:B:H142 B:B:T159 11.99296.85YesYes899
61B:B:C121 B:B:T159 11.59963.38YesYes889
62B:B:C121 B:B:C149 11.48883.64YesNo088
63B:B:C149 B:B:T102 22.67053.38NoNo088
64B:B:C148 B:B:T102 22.27053.38NoNo068
65B:B:H142 B:B:W169 16.38933.17YesYes898
66B:B:I157 B:B:W169 12.82123.52YesYes078
67B:B:C149 B:B:I157 11.58393.27NoYes087
68B:B:C148 B:B:L190 21.87039.52NoNo065
69B:B:L190 B:B:S160 21.46999.01NoNo056
70B:B:S160 B:B:V187 20.66874.85NoYes069
71R:R:L748 R:R:Q745 36.44013.99YesNo1189
72R:R:H786 R:R:L748 62.656711.57NoYes098
73R:R:H786 R:R:L782 62.36893.86NoNo098
74R:R:L782 R:R:Q778 62.0813.99NoYes089
75R:R:Q778 R:R:W753 56.93098.76YesYes199
76R:R:F533 R:R:W753 22.81254.01YesYes199
77R:R:F533 R:R:L536 12.7547.31YesYes199
78R:R:L536 R:R:W685 12.46797.97YesYes199
79R:R:I535 R:R:W685 10.60223.52NoYes089
80R:R:E636 R:R:L640 44.8929.28NoYes076
81R:R:E636 R:R:R579 44.647116.28NoYes079
82R:R:L748 R:R:R579 35.8083.64YesYes1189
83R:R:M537 R:R:W753 25.81974.65YesYes199
84R:R:F696 R:R:M537 22.85053.73YesYes199
85R:R:F696 R:R:W685 12.401213.03YesYes199
86R:R:E633 R:R:L748 11.37289.28NoYes1198
87R:R:E633 R:R:I582 16.3816.83NoNo098
88R:R:I582 R:R:W629 12.18317.05NoYes089
89R:R:F696 R:R:H620 10.22525.66YesYes199
90B:B:F278 B:B:L285 12.304410.96NoYes476
91B:B:M61 B:B:W63 17.04684.65YesYes367
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8IKL
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRE5
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1L-G13)/Beta1/Gamma2
PDB Resolution 2.33
Date 2024-01-24
D.O.I. 10.1016/j.molcel.2023.12.020
Net Summary
Imin 3.07
Number of Linked Nodes 828
Number of Links 1008
Number of Hubs 170
Number of Links mediated by Hubs 627
Number of Communities 30
Number of Nodes involved in Communities 247
Number of Links involved in Communities 350
Path Summary
Number Of Nodes in MetaPath 92
Number Of Links MetaPath 91
Number of Shortest Paths 1587395
Length Of Smallest Path 3
Average Path Length 30.9036
Length of Longest Path 55
Minimum Path Strength 1.33
Average Path Strength 6.8009
Maximum Path Strength 27.66
Minimum Path Correlation 0.7
Average Path Correlation 0.983911
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5641
Average % Of Corr. Nodes 42.2384
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.2347
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• response to stimulus   • immune response   • immune system process   • regulation of biological process   • signaling   • biological regulation   • cell-cell signaling   • cellular process   • cell communication   • cellular response to stimulus   • regulation of cellular process   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • cell surface receptor signaling pathway   • cell adhesion   • defense response   • response to stress   • inflammatory response   • cellular anatomical structure   • anchoring junction   • cell junction   • focal adhesion   • cell-substrate junction   • membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle
Gene OntologyCellular Component• cellular anatomical structure   • anchoring junction   • cell junction   • focal adhesion   • cell-substrate junction   • membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • cell periphery   • plasma membrane   • intracellular anatomical structure   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle membrane   • bounding membrane of organelle   • vesicle membrane   • cytoplasmic vesicle   • secretory granule   • secretory vesicle   • cytoplasm   • organelle membrane   • secretory granule membrane   • binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • GDP binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • cation binding   • metal ion binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • D5 dopamine receptor binding   • dopamine receptor binding   • enzyme regulator activity   • molecular function regulator activity   • nucleoside-triphosphatase regulator activity   • GTPase regulator activity   • guanyl-nucleotide exchange factor activity   • G protein activity   • cellular process   • cell division   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • regulation of molecular function   • negative regulation of lyase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • positive regulation of autophagy   • catabolic process   • macroautophagy   • autophagy   • positive regulation of biological process   • regulation of catabolic process   • regulation of autophagy   • positive regulation of catabolic process   • positive regulation of metabolic process   • regulation of macroautophagy   • metabolic process   • positive regulation of macroautophagy   • process utilizing autophagic mechanism   • regulation of metabolic process   • positive regulation of cellular process   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • nucleoside phosphate metabolic process   • ribose phosphate metabolic process   • purine nucleoside triphosphate metabolic process   • GTP metabolic process   • carbohydrate derivative metabolic process   • primary metabolic process   • nucleotide metabolic process   • purine-containing compound metabolic process   • nucleobase-containing compound metabolic process   • purine nucleotide metabolic process   • ribonucleotide metabolic process   • organophosphate metabolic process   • nucleobase-containing small molecule metabolic process   • purine ribonucleoside triphosphate metabolic process   • phosphate-containing compound metabolic process   • small molecule metabolic process   • nucleoside triphosphate metabolic process   • purine ribonucleotide metabolic process   • phosphorus metabolic process   • ribonucleoside triphosphate metabolic process   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • multicellular organismal process   • system process   • circulatory system process   • regulation of blood pressure   • blood circulation   • developmental process   • cellular developmental process   • cell differentiation   • regulation of vascular associated smooth muscle cell migration   • negative regulation of locomotion   • vascular associated smooth muscle cell migration   • regulation of cell motility   • negative regulation of vascular associated smooth muscle cell migration   • regulation of smooth muscle cell migration   • negative regulation of biological process   • smooth muscle cell migration   • muscle cell migration   • negative regulation of smooth muscle cell migration   • regulation of locomotion   • regulation of cell migration   • negative regulation of cellular process   • negative regulation of cell motility   • cell migration   • cell motility   • locomotion   • negative regulation of cell migration   • regulation of fibroblast migration   • fibroblast migration   • ameboidal-type cell migration   • multicellular organism development   • embryo development ending in birth or egg hatching   • chordate embryonic development   • anatomical structure development   • embryo development   • in utero embryonic development   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • regulation of developmental process   • regulation of cell shape   • cell morphogenesis   • regulation of cell morphogenesis   • anatomical structure morphogenesis   • regulation of anatomical structure morphogenesis   • regulation of body fluid levels   • wound healing   • cell activation   • hemostasis   • blood coagulation   • response to stress   • coagulation   • response to wounding   • platelet activation   • branching morphogenesis of an epithelial tube   • angiogenesis   • tube morphogenesis   • epithelial tube morphogenesis   • blood vessel development   • system development   • epithelium development   • blood vessel morphogenesis   • tube development   • morphogenesis of an epithelium   • tissue development   • vasculature development   • circulatory system development   • branching involved in blood vessel morphogenesis   • tissue morphogenesis   • morphogenesis of a branching structure   • anatomical structure formation involved in morphogenesis   • morphogenesis of a branching epithelium   • regulation of cellular component organization   • cellular component organization   • cellular component biogenesis   • cellular component assembly   • regulation of postsynapse assembly   • cell junction assembly   • regulation of synapse structure or activity   • synapse organization   • cellular component organization or biogenesis   • regulation of synapse assembly   • postsynapse organization   • postsynapse assembly   • regulation of postsynapse organization   • nervous system development   • regulation of cellular component biogenesis   • regulation of cell junction assembly   • regulation of synapse organization   • cell junction organization   • synapse assembly   • Rho-activating G protein-coupled receptor signaling pathway   • regulation of signaling   • small GTPase-mediated signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • intracellular signal transduction   • regulation of intracellular signal transduction   • regulation of response to stimulus   • intracellular signaling cassette   • regulation of cell communication   • Rho protein signal transduction   • regulation of vascular associated smooth muscle cell proliferation   • negative regulation of cell population proliferation   • cell population proliferation   • regulation of smooth muscle cell proliferation   • negative regulation of vascular associated smooth muscle cell proliferation   • smooth muscle cell proliferation   • negative regulation of smooth muscle cell proliferation   • regulation of cell population proliferation   • muscle cell proliferation   • vascular associated smooth muscle cell proliferation   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • lysosomal membrane   • lysosome   • Golgi apparatus   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • pigment granule   • melanosome   • brush border membrane   • cluster of actin-based cell projections   • brush border   • plasma membrane region   • cell projection membrane   • postsynapse   • synapse   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • Ras protein signal transduction   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtQ14344
Sequence
>8IKL_Chain_A
SAEDKAAVE RSKMIDKCL SREKTYVKR LVKILLLGA DNSGKSTFL 
KQMRIGIHE YDFEIKNVP FKMVDVGGQ RSERKRWFE CFDSVTSIL 
FLVDSSDFN RLTESLNDF ETIVNNRVF SNVSIILFL NKTDLLEEK 
VQIVSIKDY FLEFEGDPH CLRDVQKFL VECFRNKRR DQQQKPLYH 
HFTTAINTE NARLIFRDV KDTILHDNL KQLMLQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8IKL_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8IKL_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP48960
Sequence
>8IKL_Chain_R
SSFAILMAH YDVEDWKLT LITRVGLAL SLFCLLLCI LTFLLVRPI 
QGSRTTIHL HLCICLFVG STIFLAGIE NEGGQVGLR CRLVAGLLH 
YCFLAAFCW MSLEGLELY FLVVRVFQG QGLSTRWLC LIGYGVPLL 
IVGVSAAIY SKGYGRPRY CWLDFEQGF LWSFLGPVT FIILCNAVI 
FVTTVWKLT QKFSEINPD MKKLKKARA LTITAIAQL FLLGCTWVF 
GLFIFDDRS LVLTYVFTI LNCLQGAFL YLLHCLLNK KVREEYRKW 
A


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IKJB2AdhesionAdhesionADGRE5Homo sapiens---3.22024-02-1410.1016/j.molcel.2023.12.020
8IKLB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1L-G13)/β1/γ22.332024-01-2410.1016/j.molcel.2023.12.020
8IKL (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--2.332024-01-2410.1016/j.molcel.2023.12.020
7YDJB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-G12)/β1/γ23.032023-07-12To be published
7YDJ (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--3.032023-07-12To be published
7YDMB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.892023-07-1210.1016/j.chembiol.2023.08.003
7YDM (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--2.892023-07-1210.1016/j.chembiol.2023.08.003
7YDPB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs)/β1/γ23.12023-07-1210.1016/j.chembiol.2023.08.003
7YDP (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--3.12023-07-1210.1016/j.chembiol.2023.08.003
7YDHB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi2-G13)/β1/γ23.12023-07-1210.1016/j.chembiol.2023.08.003
7YDH (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--3.12023-07-1210.1016/j.chembiol.2023.08.003




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