Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:S532 3.905419
2R:R:F533 4.92571719
3R:R:L536 7.4725419
4R:R:M537 4.2125419
5R:R:H539 7.4775416
6R:R:D544 6.9775418
7R:R:L547 8.1025419
8R:R:T551 4.15419
9R:R:L555 5.2625419
10R:R:I575 6.0625409
11R:R:R579 8.11254129
12R:R:H583 9.544129
13R:R:H585 9.2654209
14R:R:F591 4.3425409
15R:R:C612 4.744219
16R:R:H620 5.732519
17R:R:W629 10.4845209
18R:R:M630 4.304519
19R:R:L637 5.4025409
20R:R:F639 5.6575408
21R:R:L640 5.4075406
22R:R:W654 3.0675406
23R:R:Y660 7.83254209
24R:R:P663 4.685229
25R:R:Y674 5.5725405
26R:R:Y678 4.93714719
27R:R:R680 5.2885118
28R:R:Y683 7.761676116
29R:R:W685 7.69857719
30R:R:F692 6.89333618
31R:R:L693 4.8725417
32R:R:F696 6.915419
33R:R:F711 7.53408
34R:R:F722 9.56254238
35R:R:I725 5.92408
36R:R:N726 5.29254238
37R:R:M729 5.4754237
38R:R:L748 7.4965128
39R:R:W753 8.97719
40R:R:F755 5.1025408
41R:R:Y769 7.516519
42R:R:F771 9.285419
43R:R:C776 4.345418
44R:R:Q778 5.5375419
45R:R:Y783 7.64667609
46R:R:L789 2.0754138
47R:R:V793 4.934199
48R:R:E796 5.175408
49R:R:Y797 6.214199
50A:A:L53 4.704529
51A:A:N58 8.0125109
52A:A:F64 5.655427
53A:A:Y209 8.2025407
54A:A:F211 6.7775428
55A:A:I213 5.5225425
56A:A:P217 6.635404
57A:A:F218 6.02167627
58A:A:K219 6.97476
59A:A:R227 5.88254159
60A:A:W233 9.0775409
61A:A:F237 8.4675479
62A:A:S242 4.792528
63A:A:I243 6.2225478
64A:A:L244 4.6675428
65A:A:F245 6.0475409
66A:A:L246 4.218527
67A:A:D248 9.654108
68A:A:S250 4.514109
69A:A:R264 10.174109
70A:A:F272 9.5409
71A:A:F281 5.7479
72A:A:I286 4.2775407
73A:A:F289 5.555829
74A:A:L290 6.0925409
75A:A:F309 7.31254269
76A:A:F312 7.474505
77A:A:F325 9.694266
78A:A:F330 10.1275408
79A:A:K340 7.022527
80A:A:Y343 9.124529
81A:A:F346 10.2485275
82A:A:N351 4.515429
83A:A:N354 8.555429
84A:A:F359 7.58429
85A:A:V362 3.294528
86A:A:T365 5.156526
87A:A:I366 3.2825408
88A:A:L376 3.2325138
89B:B:L7 2.542508
90B:B:L30 4.705405
91B:B:V40 5.38443
92B:B:H54 9.28667639
93B:B:L55 5.24406
94B:B:M61 4.8975436
95B:B:W63 5.67333637
96B:B:D76 7.0075439
97B:B:I81 4.9254147
98B:B:W82 10.0771739
99B:B:N88 5.5575407
100B:B:K89 7.16639
101B:B:H91 6.2485145
102B:B:I93 4.6625407
103B:B:L95 4.41254168
104B:B:W99 9.51779
105B:B:M101 5.49409
106B:B:Y105 4.362506
107B:B:N110 6.53754174
108B:B:Y111 7.27754174
109B:B:L117 5.165479
110B:B:I120 3.2475406
111B:B:C121 4.135488
112B:B:I123 4.025406
113B:B:Y124 5.211676166
114B:B:L139 8.6925409
115B:B:H142 7.354589
116B:B:Y145 6.406588
117B:B:F151 5.11667609
118B:B:L152 5.8975403
119B:B:I157 5407
120B:B:T159 6.0875489
121B:B:D163 7.454589
122B:B:C166 4.235498
123B:B:W169 9.38667688
124B:B:Q176 6.548584
125B:B:F180 8.82597
126B:B:H183 8.385699
127B:B:V187 4.426599
128B:B:F199 8.9075499
129B:B:S201 5.2625499
130B:B:D205 6.578599
131B:B:K209 11.975496
132B:B:W211 8.64167698
133B:B:Q220 7.645457
134B:B:F222 9.4625458
135B:B:H225 9.63667659
136B:B:I232 5.4775458
137B:B:F234 7.125455
138B:B:F235 7.60857746
139B:B:P236 6.3775447
140B:B:F241 7.295656
141B:B:T243 5.67458
142B:B:D247 7.9175459
143B:B:R251 12.13558
144B:B:F253 7.968556
145B:B:D258 10.0575457
146B:B:Q259 5.084296
147B:B:M262 4.9075404
148B:B:Y264 6.312545
149B:B:I269 3.906544
150B:B:R283 7.24333649
151B:B:L284 5.1405
152B:B:L285 5.178546
153B:B:Y289 7.56571747
154B:B:N295 8.028546
155B:B:V296 3.915405
156B:B:W297 6.465448
157B:B:H311 9.628569
158B:B:W332 15.1785259
159B:B:D333 8.135469
160B:B:K337 8.344566
161B:B:W339 9.826569
162B:B:N340 7.75569
163G:G:L19 3.8754289
164G:G:R27 5.352508
165G:G:Y40 10.4725446
166G:G:D48 5.866509
167G:G:P49 5.2025437
168G:G:L51 3.468506
169G:G:V54 4.33436
170G:G:F61 5.71857768
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F533 R:R:L536 12.71397.31YesYes199
2R:R:L536 R:R:W685 12.42877.97YesYes199
3R:R:I535 R:R:W685 10.56883.52NoYes089
4R:R:F533 R:R:W753 22.74064.01YesYes199
5R:R:F696 R:R:W685 12.362213.03YesYes199
6R:R:F696 R:R:M537 22.77883.73YesYes199
7R:R:M537 R:R:W753 25.73884.65YesYes199
8R:R:H786 R:R:L748 62.460611.57NoYes098
9R:R:H786 R:R:L782 62.17383.86NoNo098
10R:R:L782 R:R:Q778 61.88673.99NoYes089
11R:R:Q778 R:R:W753 56.75268.76YesYes199
12R:R:L748 R:R:R579 35.66533.64YesYes1289
13R:R:E636 R:R:R579 44.469516.28NoYes079
14R:R:L748 R:R:Q745 36.29473.99YesNo1289
15R:R:E633 R:R:L748 11.32749.28NoYes1298
16R:R:E633 R:R:I582 16.32496.83NoNo098
17R:R:I582 R:R:W629 12.14147.05NoYes089
18A:A:L374 R:R:Q745 36.51933.99NoNo059
19R:R:E636 R:R:L640 44.7149.28NoYes076
20A:A:L374 R:R:L640 39.75094.15NoYes056
21A:A:N370 R:R:L640 84.64786.87NoYes086
22A:A:I366 A:A:N370 84.74394.25YesNo088
23A:A:F218 A:A:V216 93.49026.55YesNo074
24A:A:F218 A:A:V362 88.17523.93YesYes278
25A:A:I366 A:A:V362 84.4993.07YesYes088
26A:A:P217 A:A:V216 99.5823.53YesNo044
27A:A:S242 A:A:V362 10.60273.23YesYes288
28B:B:K89 B:B:W82 10.23669.28YesYes399
29B:B:L70 B:B:W82 13.58286.83NoYes359
30B:B:L70 B:B:M61 12.60218.48NoYes356
31B:B:C317 B:B:M61 29.96143.24NoYes076
32B:B:C317 B:B:S316 30.12373.44NoNo079
33B:B:S316 B:B:W332 30.28784.94NoYes099
34B:B:W332 B:B:Y59 65.82047.72YesNo2598
35B:B:Q75 B:B:Y59 66.27076.76NoNo098
36B:B:Q75 B:B:W99 66.396720.81NoYes099
37A:A:E208 B:B:W99 99.67147.63NoYes799
38A:A:E208 A:A:K219 1005.4NoYes796
39A:A:K219 A:A:L48 49.9669.87YesNo766
40A:A:L48 A:A:Y44 50.09623.52NoNo062
41A:A:P217 A:A:Y44 99.99338.34YesNo042
42A:A:D210 A:A:K219 49.96628.3NoYes036
43A:A:D210 A:A:Y44 49.96514.6NoNo032
44A:A:F237 B:B:W99 28.78969.02YesYes799
45A:A:F237 A:A:L52 30.092312.18YesNo799
46A:A:I243 A:A:L52 29.41567.14YesNo789
47A:A:F272 A:A:V276 14.809914.42YesNo096
48A:A:I286 A:A:V276 15.77594.61YesNo076
49A:A:I243 A:A:I286 31.32315.89YesYes087
50A:A:F272 A:A:R334 14.79043.21YesNo097
51A:A:I286 A:A:R334 15.17693.76YesNo077
52A:A:F312 A:A:I305 10.53138.79YesNo056
53A:A:F312 A:A:F325 14.951318.22YesYes056
54A:A:C329 A:A:F325 17.35338.38NoYes056
55A:A:C329 A:A:L269 17.7533.17NoNo056
56A:A:F330 A:A:L269 18.152612.18YesNo086
57A:A:F272 A:A:F330 24.461910.72YesYes098
58B:B:G162 B:B:S161 31.18583.71NoNo899
59B:B:G162 B:B:Y145 31.23254.35NoYes898
60B:B:M101 B:B:Y145 27.59874.79YesYes098
61A:A:C236 B:B:M101 28.32373.24NoYes099
62A:A:C236 B:B:W99 28.40323.92NoYes799
63B:B:R314 B:B:W332 37.651123.99NoYes089
64B:B:Q259 B:B:R22 15.79917.01YesNo066
65B:B:A257 B:B:Q259 16.92383.03NoYes076
66B:B:A257 B:B:D254 17.11064.63NoNo079
67B:B:D254 B:B:L261 17.48385.43NoNo095
68B:B:L252 B:B:L261 15.97972.77NoNo075
69B:B:L252 B:B:Y264 16.14827.03NoYes075
70B:B:W297 B:B:Y264 26.59068.68YesYes485
71B:B:W297 B:B:Y289 26.65315.79YesYes487
72B:B:C271 B:B:Y289 35.70924.03NoYes457
73B:B:C271 B:B:D290 36.56324.67NoNo056
74B:B:D290 B:B:R314 36.868714.29NoNo068
75B:B:D258 B:B:R22 10.631714.29YesNo076
76B:B:F278 B:B:L285 12.293110.96NoYes476
77B:B:T321 B:B:W63 10.295310.92NoYes377
78B:B:M61 B:B:W63 17.03294.65YesYes367
79B:B:C148 B:B:T102 22.23943.38NoNo068
80B:B:C149 B:B:T102 22.63893.38NoNo088
81B:B:C121 B:B:C149 11.47293.64YesNo088
82B:B:C121 B:B:T159 11.58383.38YesYes889
83B:B:H142 B:B:T159 11.97666.85YesYes899
84B:B:H142 B:B:S161 29.212316.74YesNo899
85B:B:C149 B:B:I157 11.56763.27NoYes087
86B:B:I157 B:B:W169 12.80363.52YesYes078
87B:B:H142 B:B:W169 16.36693.17YesYes898
88B:B:L190 B:B:S160 21.449.01NoNo056
89B:B:C148 B:B:L190 21.83989.52NoNo065
90B:B:S160 B:B:V187 20.63984.85NoYes069
91R:R:F696 R:R:H620 10.19315.66YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8IKL
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRE5
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1L-G13)/Beta1/Gamma2
PDB Resolution 2.33
Date 2024-01-24
D.O.I. 10.1016/j.molcel.2023.12.020
Net Summary
Imin 3.07
Number of Linked Nodes 827
Number of Links 1009
Number of Hubs 170
Number of Links mediated by Hubs 628
Number of Communities 30
Number of Nodes involved in Communities 248
Number of Links involved in Communities 352
Path Summary
Number Of Nodes in MetaPath 92
Number Of Links MetaPath 91
Number of Shortest Paths 1593715
Length Of Smallest Path 3
Average Path Length 30.8936
Length of Longest Path 55
Minimum Path Strength 1.33
Average Path Strength 6.79719
Maximum Path Strength 27.66
Minimum Path Correlation 0.71
Average Path Correlation 0.984253
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5641
Average % Of Corr. Nodes 42.3185
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.1483
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP48960
Sequence
>8IKL_Chain_R
SSFAILMAH YDVEDWKLT LITRVGLAL SLFCLLLCI LTFLLVRPI 
QGSRTTIHL HLCICLFVG STIFLAGIE NEGGQVGLR CRLVAGLLH 
YCFLAAFCW MSLEGLELY FLVVRVFQG QGLSTRWLC LIGYGVPLL 
IVGVSAAIY SKGYGRPRY CWLDFEQGF LWSFLGPVT FIILCNAVI 
FVTTVWKLT QKFSEINPD MKKLKKARA LTITAIAQL FLLGCTWVF 
GLFIFDDRS LVLTYVFTI LNCLQGAFL YLLHCLLNK KVREEYRKW 
A


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtQ14344
Sequence
>8IKL_Chain_A
SAEDKAAVE RSKMIDKCL SREKTYVKR LVKILLLGA DNSGKSTFL 
KQMRIGIHE YDFEIKNVP FKMVDVGGQ RSERKRWFE CFDSVTSIL 
FLVDSSDFN RLTESLNDF ETIVNNRVF SNVSIILFL NKTDLLEEK 
VQIVSIKDY FLEFEGDPH CLRDVQKFL VECFRNKRR DQQQKPLYH 
HFTTAINTE NARLIFRDV KDTILHDNL KQLMLQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8IKL_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8IKL_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YDHB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi2-G13)/&β;1/&γ;23.12023-07-1210.1016/j.chembiol.2023.08.003
7YDJB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-G12)/&β;1/&γ;23.032023-07-12To be published
7YDMB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.892023-07-1210.1016/j.chembiol.2023.08.003
7YDPB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;23.12023-07-1210.1016/j.chembiol.2023.08.003
8IKJB2AdhesionAdhesionADGRE5Homo sapiens---3.22024-02-1410.1016/j.molcel.2023.12.020
8IKLB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1L-G13)/&β;1/&γ;22.332024-01-2410.1016/j.molcel.2023.12.020




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8IKL.zip



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