Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F533 3.89529
2R:R:M537 3.325429
3R:R:H583 7.075459
4R:R:H585 7.39439
5R:R:I596 2.5525406
6R:R:H620 3.95409
7R:R:Y621 3.0575406
8R:R:W629 6.23875839
9R:R:E633 6.572559
10R:R:Y660 6.28439
11R:R:P663 2.974509
12R:R:Y674 6.92415
13R:R:Y678 2.93833619
14R:R:R680 4.8825478
15R:R:W685 5.655409
16R:R:F692 4.85518
17R:R:L697 3.855427
18R:R:F711 4.07408
19R:R:N726 4.43488
20R:R:I740 1.7225407
21R:R:F747 5.935405
22R:R:W753 6.35167629
23R:R:F755 2.5525408
24R:R:Y769 4.405449
25R:R:F771 4.908529
26R:R:N775 6.398529
27R:R:C776 2.8775408
28R:R:Y783 5.335609
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I759 R:R:T768 10.83456.08NoNo087
2R:R:G756 R:R:I759 13.78133.53NoNo098
3R:R:F771 R:R:G756 15.27373.01YesNo099
4R:R:F533 R:R:L536 53.08014.87YesNo099
5R:R:L536 R:R:W685 55.18865.69NoYes099
6R:R:L619 R:R:W685 25.28263.42NoYes099
7R:R:F533 R:R:W753 51.53694.01YesYes299
8R:R:F533 R:R:N775 10.45982.42YesYes299
9R:R:C776 R:R:F533 34.24362.79YesYes089
10R:R:L686 R:R:L693 17.71882.77NoNo097
11R:R:L686 R:R:W685 26.349611.39NoYes099
12R:R:C776 R:R:T772 19.01441.69YesNo089
13R:R:L547 R:R:T772 14.68942.95NoNo099
14R:R:L547 R:R:Y769 13.23517.03NoYes099
15R:R:C776 R:R:T551 12.94935.07YesNo089
16R:R:L555 R:R:T551 11.37431.47NoNo099
17R:R:G779 R:R:L782 12.56833.42NoNo098
18R:R:L782 R:R:Q778 14.61963.99NoNo089
19R:R:F747 R:R:Q778 16.65822.34YesNo059
20R:R:F747 R:R:T752 24.68563.89YesNo059
21R:R:T752 R:R:W753 18.48722.43NoYes299
22R:R:C787 R:R:Y783 29.53136.72NoYes099
23R:R:C787 R:R:F569 49.42842.79NoNo099
24R:R:F569 R:R:H583 55.94446.79NoYes099
25R:R:E633 R:R:H583 50.31758.62YesYes599
26R:R:E633 R:R:I582 95.42746.83YesNo098
27R:R:I582 R:R:W629 1007.05NoYes089
28R:R:L586 R:R:W629 76.93382.28NoYes099
29R:R:L586 R:R:M630 76.92112.83NoNo099
30R:R:F627 R:R:M630 76.89573.73NoNo099
31R:R:F627 R:R:W753 72.043714.03NoYes099
32R:R:C787 R:R:T568 18.63973.38NoNo099
33R:R:T568 R:R:Y797 17.14097.49NoNo099
34R:R:Y783 R:R:Y797 17.62991.99YesNo099
35R:R:I575 R:R:K792 22.35495.82NoNo099
36R:R:K792 R:R:N790 25.49854.2NoNo099
37R:R:N790 R:R:V793 28.62954.43NoNo099
38R:R:V793 R:R:Y797 31.7357.57NoNo099
39R:R:I575 R:R:V572 19.19854.61NoNo099
40R:R:Y621 R:R:Y660 25.83512.98YesYes069
41R:R:P663 R:R:Y621 22.78675.56YesYes096
42R:R:P663 R:R:V662 37.58413.53YesNo097
43R:R:I666 R:R:V662 37.04433.07NoNo087
44R:R:I666 R:R:L624 35.50744.28NoNo089
45R:R:H620 R:R:L624 34.9745.14YesNo099
46R:R:H620 R:R:W685 17.56642.12YesYes099
47R:R:E633 R:R:L748 33.63395.3YesNo598
48R:R:I596 R:R:L619 14.68314.28YesNo069
49R:R:G679 R:R:R613 11.07583NoNo196
50R:R:R613 R:R:Y678 15.46421.03NoYes169
51R:R:H620 R:R:Y678 30.83324.36YesYes099
52R:R:C628 R:R:P663 18.7731.88NoYes079
53R:R:C628 R:R:G659 19.50341.96NoNo079
54R:R:L632 R:R:W629 18.35392.28NoYes099
55R:R:E633 R:R:G634 11.95221.64YesNo099
56R:R:G634 R:R:L749 10.2821.71NoNo099
57R:R:F639 R:R:L635 11.79987.31NoNo087
58R:R:L632 R:R:L635 13.45741.38NoNo097
59R:R:F692 R:R:Y674 11.27273.09YesYes185
60R:R:F711 R:R:Q745 13.71782.34YesNo089
61R:R:A744 R:R:Q745 20.25913.03NoNo099
62R:R:A744 R:R:L785 21.87221.58NoNo098
63R:R:H786 R:R:L785 37.30472.57NoNo098
64R:R:H786 R:R:L748 38.7412.86NoNo098
65R:R:I740 R:R:L785 15.3881.43YesNo078
66R:R:W629 R:R:Y660 23.421811.58YesYes399
67R:R:G659 R:R:W629 20.27185.63NoYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7YDM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 1.84
Number of Linked Nodes 244
Number of Links 267
Number of Hubs 28
Number of Links mediated by Hubs 108
Number of Communities 8
Number of Nodes involved in Communities 40
Number of Links involved in Communities 52
Path Summary
Number Of Nodes in MetaPath 68
Number Of Links MetaPath 67
Number of Shortest Paths 33918
Length Of Smallest Path 3
Average Path Length 13.2731
Length of Longest Path 30
Minimum Path Strength 1.17
Average Path Strength 4.68206
Maximum Path Strength 14.295
Minimum Path Correlation 0.7
Average Path Correlation 0.933086
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 5
Average % Of Corr. Nodes 57.1805
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 33.6995
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • D2 dopamine receptor binding   • adenylate cyclase inhibitor activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • enzyme inhibitor activity   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • cellular homeostasis   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • intracellular chemical homeostasis   • intracellular glucose homeostasis   • system process   • regulation of biological process   • nervous system process   • neuromuscular process   • regulation of system process   • biological regulation   • skeletal muscle contraction   • muscle contraction   • muscle system process   • regulation of muscle system process   • striated muscle contraction   • multicellular organismal movement   • musculoskeletal movement   • regulation of striated muscle contraction   • regulation of muscle contraction   • regulation of skeletal muscle contraction   • regulation of multicellular organismal process   • sensory perception of chemical stimulus   • sensory perception   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • response to pH   • cellular response to pH   • response to abiotic stimulus   • cellular response to acidic pH   • response to acidic pH   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • positive regulation of biological process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • positive regulation of cell communication   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • localization   • establishment of localization in cell   • positive regulation of insulin secretion involved in cellular response to glucose stimulus   • positive regulation of insulin secretion   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular response to carbohydrate stimulus   • response to glucose   • positive regulation of protein localization   • insulin secretion involved in cellular response to glucose stimulus   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • response to monosaccharide   • response to carbohydrate   • positive regulation of secretion   • signal release   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • positive regulation of cellular process   • positive regulation of peptide secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • cellular response to glucose stimulus   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • response to hexose   • positive regulation of transport   • regulation of cellular localization   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • regulation of insulin secretion involved in cellular response to glucose stimulus   • hormone transport   • regulation of cell communication   • insulin secretion   • positive regulation of signaling   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • cellular response to catecholamine stimulus   • serotonin receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-activating serotonin receptor signaling pathway   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • adenylate cyclase-activating dopamine receptor signaling pathway   • G protein-coupled dopamine receptor signaling pathway   • cell surface receptor signaling pathway   • bile acid signaling pathway   • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway   • renal system process   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • neuropeptide signaling pathway   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • cell division   • leukocyte migration   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • response to cytokine   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • response to peptide   • cellular response to cytokine stimulus   • relaxation of smooth muscle   • relaxation of muscle   • positive regulation of relaxation of smooth muscle   • positive regulation of relaxation of muscle   • regulation of relaxation of smooth muscle   • regulation of relaxation of muscle   • negative regulation of protein transport   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • negative regulation of peptide hormone secretion   • negative regulation of establishment of protein localization   • negative regulation of protein secretion   • negative regulation of signaling   • negative regulation of cell communication   • negative regulation of peptide secretion   • negative regulation of cellular process   • negative regulation of protein localization   • negative regulation of insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cell projection   • sperm principal piece   • cilium   • 9+2 motile cilium   • sperm flagellum   • motile cilium   • plasma membrane bounded cell projection   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • ciliary basal body   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • cation binding   • ion binding   • calcium ion binding   • metal ion binding   • small molecule binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • immune response   • immune system process   • cell surface receptor signaling pathway   • cell adhesion   • defense response   • response to stress   • inflammatory response   • anchoring junction   • focal adhesion   • cell-substrate junction   • intracellular vesicle   • cytoplasmic vesicle membrane   • vesicle membrane   • cytoplasmic vesicle   • secretory granule   • secretory vesicle   • secretory granule membrane
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP48960
Sequence
>7YDM_nogp_Chain_R
SSFAILMAH YDVEDWKLT LITRVGLAL SLFCLLLCI LTFLLVRPI 
QGSRTTIHL HLCICLFVG STIFLAGIE NEGGQVGLR CRLVAGLLH 
YCFLAAFCW MSLEGLELY FLVVRVFQG QGLSTRWLC LIGYGVPLL 
IVGVSAAIY SKGYGRPRY CWLDFEQGF LWSFLGPVT FIILCNAVI 
FVTTVWKLT QKFSEINPD MKKLKKARA LTITAIAQL FLLGCTWVF 
GLFIFDDRS LVLTYVFTI LNCLQGAFL YLLHCLLNK KVREEYRKW 
ACLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YDHB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi2-G13)/β1/γ23.12023-07-12doi.org/10.1016/j.chembiol.2023.08.003
7YDH (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--3.12023-07-12doi.org/10.1016/j.chembiol.2023.08.003
7YDJB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-G12)/β1/γ23.032023-07-12To be published
7YDJ (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--3.032023-07-12To be published
7YDMB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.892023-07-12doi.org/10.1016/j.chembiol.2023.08.003
7YDM (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--2.892023-07-12doi.org/10.1016/j.chembiol.2023.08.003
7YDPB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs)/β1/γ23.12023-07-12doi.org/10.1016/j.chembiol.2023.08.003
7YDP (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--3.12023-07-12doi.org/10.1016/j.chembiol.2023.08.003
8IKLB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1L-G13)/β1/γ22.332024-01-24doi.org/10.1016/j.molcel.2023.12.020
8IKL (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--2.332024-01-24doi.org/10.1016/j.molcel.2023.12.020
8IKJB2AdhesionAdhesionADGRE5Homo sapiens---3.22024-02-14doi.org/10.1016/j.molcel.2023.12.020




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