psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I601	R:R:S531	3.1	No	No	0	7	9
2	R:R:E602	R:R:S531	7.19	No	No	0	7	9
3	R:R:I535	R:R:S532	3.1	No	No	0	8	9
4	R:R:F533	R:R:L536	4.87	Yes	No	0	9	9
5	R:R:F533	R:R:W753	4.01	Yes	Yes	2	9	9
6	R:R:F533	R:R:F771	5.36	Yes	Yes	2	9	9
7	R:R:F533	R:R:N775	2.42	Yes	Yes	2	9	9
8	R:R:C776	R:R:F533	2.79	Yes	Yes	0	8	9
9	R:R:I535	R:R:Y683	8.46	No	No	0	8	6
10	R:R:F623	R:R:L536	2.44	No	No	0	8	9
11	R:R:L536	R:R:W685	5.69	No	Yes	0	9	9
12	R:R:L697	R:R:M537	5.65	Yes	Yes	2	7	9
13	R:R:M537	R:R:W753	2.33	Yes	Yes	2	9	9
14	R:R:L757	R:R:M537	2.83	No	Yes	2	5	9
15	R:R:F771	R:R:M537	2.49	Yes	Yes	2	9	9
16	R:R:H539	R:R:L693	2.57	No	No	0	6	7
17	R:R:F760	R:R:H539	4.53	No	No	0	8	6
18	R:R:V542	R:R:Y540	13.88	No	No	0	6	6
19	R:R:D762	R:R:Y540	5.75	No	No	0	5	6
20	R:R:D544	R:R:W545	4.47	No	No	4	8	5
21	R:R:D544	R:R:K546	16.59	No	No	4	8	4
22	R:R:D544	R:R:Y769	3.45	No	Yes	4	8	9
23	R:R:K546	R:R:W545	8.12	No	No	4	4	5
24	R:R:K546	R:R:Y769	5.97	No	Yes	4	4	9
25	R:R:L547	R:R:Y769	7.03	No	Yes	0	9	9
26	R:R:L547	R:R:T772	2.95	No	No	0	9	9
27	R:R:R552	R:R:T548	5.17	No	No	0	5	4
28	R:R:I550	R:R:I773	2.94	No	No	0	8	8
29	R:R:C776	R:R:T551	5.07	Yes	No	0	8	9
30	R:R:G554	R:R:V553	1.84	No	No	0	9	7
31	R:R:C776	R:R:G554	1.96	Yes	No	0	8	9
32	R:R:L555	R:R:S594	3	No	No	0	9	8
33	R:R:L555	R:R:L598	6.92	No	No	0	9	9
34	R:R:G779	R:R:S558	3.71	No	No	0	9	9
35	R:R:F591	R:R:L559	6.09	No	No	6	9	8
36	R:R:L559	R:R:S594	3	No	No	0	8	8
37	R:R:L559	R:R:T595	2.95	No	No	6	8	6
38	R:R:C561	R:R:Y783	4.03	No	Yes	0	9	9
39	R:R:C587	R:R:L562	3.17	No	No	0	8	9
40	R:R:G779	R:R:L562	5.13	No	No	0	9	9
41	R:R:F591	R:R:L563	2.44	No	No	0	9	5
42	R:R:L564	R:R:Y783	8.21	No	Yes	0	8	9
43	R:R:C565	R:R:Y783	4.03	No	Yes	0	7	9
44	R:R:C787	R:R:T568	3.38	No	No	0	9	9
45	R:R:T568	R:R:Y797	7.49	No	No	0	9	9
46	R:R:F569	R:R:H583	6.79	No	Yes	0	9	9
47	R:R:F569	R:R:L584	2.44	No	No	0	9	9
48	R:R:C787	R:R:F569	2.79	No	No	0	9	9
49	R:R:L570	R:R:L571	2.77	No	No	0	6	7
50	R:R:L571	R:R:W800	3.42	No	No	0	7	6
51	R:R:I575	R:R:V572	4.61	No	No	0	9	9
52	R:R:E796	R:R:V572	4.28	No	No	0	8	9
53	R:R:I575	R:R:K792	5.82	No	No	0	9	9
54	R:R:E636	R:R:S578	5.75	No	No	0	7	8
55	R:R:H583	R:R:R579	9.03	Yes	No	5	9	9
56	R:R:E633	R:R:R579	10.47	Yes	No	5	9	9
57	R:R:L637	R:R:R579	2.43	No	No	0	9	9
58	R:R:H585	R:R:T581	2.74	Yes	No	0	9	9
59	R:R:I582	R:R:W629	7.05	No	Yes	0	8	9
60	R:R:E633	R:R:I582	6.83	Yes	No	0	9	8
61	R:R:E633	R:R:H583	8.62	Yes	Yes	5	9	9
62	R:R:H583	R:R:L748	3.86	Yes	No	5	9	8
63	R:R:H585	R:R:W629	15.87	Yes	Yes	3	9	9
64	R:R:C656	R:R:H585	4.42	No	Yes	3	4	9
65	R:R:H585	R:R:Y660	6.53	Yes	Yes	3	9	9
66	R:R:L586	R:R:L590	4.15	No	No	0	9	9
67	R:R:L586	R:R:W629	2.28	No	Yes	0	9	9
68	R:R:L586	R:R:M630	2.83	No	No	0	9	9
69	R:R:C589	R:R:W629	2.61	No	Yes	3	8	9
70	R:R:C589	R:R:Y660	4.03	No	Yes	3	8	9
71	R:R:F591	R:R:T595	3.89	No	No	6	9	6
72	R:R:G593	R:R:V592	1.84	No	No	0	9	6
73	R:R:C622	R:R:G593	1.96	No	No	0	7	9
74	R:R:I596	R:R:L618	2.85	Yes	No	0	6	8
75	R:R:I596	R:R:L619	4.28	Yes	No	0	6	9
76	R:R:F597	R:R:I601	10.05	No	No	0	9	7
77	R:R:F597	R:R:L619	2.44	No	No	0	9	9
78	R:R:A599	R:R:G600	1.95	No	No	0	6	8
79	R:R:C684	R:R:N603	3.15	No	No	0	9	6
80	R:R:G605	R:R:G606	2.11	No	No	0	7	6
81	R:R:R613	R:R:V608	6.54	No	No	1	6	6
82	R:R:G679	R:R:V608	1.84	No	No	1	9	6
83	R:R:R611	R:R:V615	2.62	No	No	0	7	8
84	R:R:C612	R:R:G679	1.96	No	No	0	9	9
85	R:R:C612	R:R:C684	7.28	No	No	0	9	9
86	R:R:G679	R:R:R613	3	No	No	1	9	6
87	R:R:A616	R:R:G617	1.95	No	No	1	9	8
88	R:R:A616	R:R:Y678	2.67	No	Yes	1	9	9
89	R:R:G617	R:R:Y678	2.9	No	Yes	1	8	9
90	R:R:L619	R:R:W685	3.42	No	Yes	0	9	9
91	R:R:H620	R:R:L624	5.14	Yes	No	0	9	9
92	R:R:H620	R:R:Y678	4.36	Yes	Yes	0	9	9
93	R:R:H620	R:R:W685	2.12	Yes	Yes	0	9	9
94	R:R:H620	R:R:S695	4.18	Yes	No	0	9	8
95	R:R:Y621	R:R:Y660	2.98	Yes	Yes	0	6	9
96	R:R:P663	R:R:Y621	5.56	Yes	Yes	0	9	6
97	R:R:V667	R:R:Y621	2.52	No	Yes	0	9	6
98	R:R:F623	R:R:F696	2.14	No	No	0	8	9
99	R:R:I666	R:R:L624	4.28	No	No	0	8	9
100	R:R:A625	R:R:P663	1.87	No	Yes	0	9	9
101	R:R:F627	R:R:M630	3.73	No	No	0	9	9
102	R:R:F627	R:R:V700	11.8	No	No	0	9	8
103	R:R:F627	R:R:W753	14.03	No	Yes	0	9	9
104	R:R:C628	R:R:G659	1.96	No	No	0	7	9
105	R:R:C628	R:R:P663	1.88	No	Yes	0	7	9
106	R:R:L632	R:R:W629	2.28	No	Yes	0	9	9
107	R:R:C656	R:R:W629	2.61	No	Yes	3	4	9
108	R:R:G659	R:R:W629	5.63	No	Yes	0	9	9
109	R:R:W629	R:R:Y660	11.58	Yes	Yes	3	9	9
110	R:R:G750	R:R:M630	3.49	No	No	0	9	9
111	R:R:I703	R:R:S631	4.64	No	No	0	9	7
112	R:R:L632	R:R:L655	4.15	No	No	0	9	7
113	R:R:E633	R:R:L748	5.3	Yes	No	5	9	8
114	R:R:F639	R:R:L635	7.31	No	No	0	8	7
115	R:R:I710	R:R:L637	2.85	No	No	0	7	9
116	R:R:L637	R:R:T714	4.42	No	No	0	9	9
117	R:R:F639	R:R:Y638	4.13	No	No	0	8	8
118	R:R:V642	R:R:Y638	10.09	No	No	0	9	8
119	R:R:F639	R:R:R643	12.83	No	No	0	8	7
120	R:R:K717	R:R:V641	4.55	No	No	0	8	9
121	R:R:L650	R:R:L655	2.77	No	No	0	5	7
122	R:R:S651	R:R:W654	6.18	No	No	0	6	6
123	R:R:L657	R:R:W654	2.28	No	No	0	7	6
124	R:R:G661	R:R:P663	2.03	No	Yes	0	9	9
125	R:R:P663	R:R:V662	3.53	Yes	No	0	9	7
126	R:R:I666	R:R:V662	3.07	No	No	0	8	7
127	R:R:I666	R:R:P699	3.39	No	No	0	8	9
128	R:R:G668	R:R:V667	1.84	No	No	0	6	9
129	R:R:S670	R:R:Y678	2.54	No	Yes	1	9	9
130	R:R:F692	R:R:S670	7.93	Yes	No	1	8	9
131	R:R:S670	R:R:S695	4.89	No	No	0	9	8
132	R:R:K676	R:R:Y674	19.11	No	Yes	0	3	5
133	R:R:G677	R:R:Y674	4.35	No	Yes	1	8	5
134	R:R:F692	R:R:Y674	3.09	Yes	Yes	1	8	5
135	R:R:F692	R:R:G677	3.01	Yes	No	1	8	8
136	R:R:F692	R:R:Y678	4.13	Yes	Yes	1	8	9
137	R:R:P681	R:R:R680	4.32	No	Yes	0	3	8
138	R:R:F688	R:R:R680	12.83	No	Yes	7	4	8
139	R:R:R682	R:R:Y683	8.23	No	No	0	4	6
140	R:R:L686	R:R:W685	11.39	No	Yes	0	9	9
141	R:R:F692	R:R:L686	6.09	Yes	No	0	8	9
142	R:R:L686	R:R:L693	2.77	No	No	0	9	7
143	R:R:F688	R:R:L693	2.44	No	No	0	4	7
144	R:R:E689	R:R:Q690	3.82	No	No	0	3	2
145	R:R:L697	R:R:W694	4.56	Yes	No	0	7	8
146	R:R:F696	R:R:L697	2.44	No	Yes	0	9	7
147	R:R:F696	R:R:V700	3.93	No	No	0	9	8
148	R:R:L697	R:R:L757	2.77	Yes	No	2	7	5
149	R:R:G698	R:R:P699	4.06	No	No	0	8	9
150	R:R:L757	R:R:T701	2.95	No	No	0	5	7
151	R:R:C706	R:R:F702	4.19	No	No	0	5	4
152	R:R:I703	R:R:N707	2.83	No	No	0	9	9
153	R:R:I704	R:R:L705	2.85	No	No	0	6	5
154	R:R:L749	R:R:N707	12.36	No	No	0	9	9
155	R:R:F711	R:R:V715	5.24	Yes	No	0	8	6
156	R:R:F711	R:R:Q745	2.34	Yes	No	0	8	9
157	R:R:F711	R:R:L746	7.31	Yes	No	0	8	7
158	R:R:Q720	R:R:W716	13.14	No	No	0	5	8
159	R:R:L718	R:R:L738	2.77	No	No	0	8	9
160	R:R:F722	R:R:N726	4.83	No	Yes	8	8	8
161	R:R:F722	R:R:M729	3.73	No	No	8	8	7
162	R:R:F722	R:R:K734	8.69	No	No	0	8	7
163	R:R:I725	R:R:N726	4.25	No	Yes	0	8	8
164	R:R:M729	R:R:N726	7.01	No	Yes	8	7	8
165	R:R:K733	R:R:R736	3.71	No	No	0	5	8
166	R:R:I740	R:R:R736	2.51	Yes	No	0	7	8
167	R:R:Q745	R:R:T741	4.25	No	No	0	9	9
168	R:R:F747	R:R:I743	2.51	Yes	No	0	5	6
169	R:R:A744	R:R:Q745	3.03	No	No	0	9	9
170	R:R:C751	R:R:L746	3.17	No	No	0	5	7
171	R:R:F747	R:R:T752	3.89	Yes	No	0	5	9
172	R:R:F747	R:R:Q778	2.34	Yes	No	0	5	9
173	R:R:F747	R:R:F781	15	Yes	No	0	5	8
174	R:R:H786	R:R:L748	12.86	No	No	0	9	8
175	R:R:T752	R:R:W753	2.43	No	Yes	2	9	9
176	R:R:N775	R:R:T752	5.85	Yes	No	2	9	9
177	R:R:F771	R:R:W753	4.01	Yes	Yes	2	9	9
178	R:R:N775	R:R:W753	11.3	Yes	Yes	2	9	9
179	R:R:F755	R:R:V754	2.62	Yes	No	0	8	6
180	R:R:F755	R:R:V770	3.93	Yes	No	0	8	6
181	R:R:F755	R:R:L774	2.44	Yes	No	0	8	7
182	R:R:G756	R:R:I759	3.53	No	No	0	9	8
183	R:R:F771	R:R:G756	3.01	Yes	No	0	9	9
184	R:R:I759	R:R:T768	6.08	No	No	0	8	7
185	R:R:D761	R:R:F760	2.39	No	No	0	4	8
186	R:R:D761	R:R:R763	26.2	No	No	0	4	4
187	R:R:F771	R:R:N775	9.67	Yes	Yes	2	9	9
188	R:R:L774	R:R:N775	2.75	No	Yes	0	7	9
189	R:R:F781	R:R:L777	2.44	No	No	0	8	8
190	R:R:L782	R:R:Q778	3.99	No	No	0	8	9
191	R:R:G779	R:R:L782	3.42	No	No	0	9	8
192	R:R:C787	R:R:Y783	6.72	No	Yes	0	9	9
193	R:R:L788	R:R:Y783	7.03	No	Yes	0	8	9
194	R:R:Y783	R:R:Y797	1.99	Yes	No	0	9	9
195	R:R:H786	R:R:L785	2.57	No	No	0	9	8
196	R:R:K792	R:R:N790	4.2	No	No	0	9	9
197	R:R:N790	R:R:V793	4.43	No	No	0	9	9
198	R:R:K791	R:R:R794	2.48	No	No	0	8	8
199	R:R:V793	R:R:Y797	7.57	No	No	0	9	9
200	R:R:R794	R:R:R798	2.13	No	No	0	8	4
201	R:R:K799	R:R:L803	7.05	No	No	0	5	4
202	R:R:G577	R:R:T580	1.82	No	No	0	8	9
203	R:R:A780	R:R:C561	1.81	No	No	0	5	9
204	R:R:A626	R:R:C589	1.81	No	No	0	8	8
205	R:R:P574	R:R:V572	1.77	No	No	0	8	9
206	R:R:A534	R:R:S532	1.71	No	No	0	9	9
207	R:R:G634	R:R:L749	1.71	No	No	0	9	9
208	R:R:A671	R:R:S675	1.71	No	No	0	8	6
209	R:R:C656	R:R:T652	1.69	No	No	0	4	6
210	R:R:C776	R:R:T772	1.69	Yes	No	0	8	9
211	R:R:A534	R:R:T768	1.68	No	No	0	9	7
212	R:R:C587	R:R:I566	1.64	No	No	0	8	9
213	R:R:G577	R:R:Q576	1.64	No	No	0	8	8
214	R:R:E633	R:R:G634	1.64	Yes	No	0	9	9
215	R:R:G647	R:R:Q646	1.64	No	No	0	5	7
216	R:R:N726	R:R:P727	1.63	Yes	No	0	8	6
217	R:R:S532	R:R:V542	1.62	No	No	0	9	6
218	R:R:A538	R:R:I759	1.62	No	No	0	9	8
219	R:R:C561	R:R:L557	1.59	No	No	0	9	6
220	R:R:T713	R:R:V642	1.59	No	No	0	6	9
221	R:R:T719	R:R:V715	1.59	No	No	0	8	6
222	R:R:A744	R:R:L785	1.58	No	No	0	9	8
223	R:R:T580	R:R:T581	1.57	No	No	0	9	9
224	R:R:C706	R:R:N707	1.57	No	No	0	5	9
225	R:R:I596	R:R:V592	1.54	Yes	No	0	6	6
226	R:R:I596	R:R:V615	1.54	Yes	No	0	6	8
227	R:R:I673	R:R:V669	1.54	No	No	0	5	7
228	R:R:I704	R:R:V700	1.54	No	No	0	6	8
229	R:R:I550	R:R:T772	1.52	No	No	0	8	9
230	R:R:I740	R:R:T739	1.52	Yes	No	0	7	9
231	R:R:G600	R:R:R611	1.5	No	No	0	8	7
232	R:R:G647	R:R:R643	1.5	No	No	0	5	7
233	R:R:L640	R:R:V641	1.49	No	No	0	6	9
234	R:R:L665	R:R:V669	1.49	No	No	0	5	7
235	R:R:L555	R:R:T551	1.47	No	No	0	9	9
236	R:R:I566	R:R:I588	1.47	No	No	0	9	7
237	R:R:L718	R:R:T741	1.47	No	No	0	8	9
238	R:R:L738	R:R:T719	1.47	No	No	0	9	8
239	R:R:D761	R:R:S764	1.47	No	No	0	4	7
240	R:R:P574	R:R:R573	1.44	No	No	0	8	8
241	R:R:K731	R:R:K734	1.44	No	No	0	6	7
242	R:R:I740	R:R:L785	1.43	Yes	No	0	7	8
243	R:R:I740	R:R:L789	1.43	Yes	No	0	7	8
244	R:R:Q720	R:R:T719	1.42	No	No	0	5	8
245	R:R:G691	R:R:W694	1.41	No	No	0	6	8
246	R:R:A742	R:R:F711	1.39	No	Yes	0	9	8
247	R:R:L570	R:R:L584	1.38	No	No	0	6	9
248	R:R:L632	R:R:L635	1.38	No	No	0	9	7
249	R:R:L784	R:R:L788	1.38	No	No	0	5	8
250	R:R:E636	R:R:I582	1.37	No	No	0	7	8
251	R:R:E796	R:R:K799	1.35	No	No	0	8	5
252	R:R:E636	R:R:L640	1.33	No	No	0	7	6
253	R:R:R552	R:R:S531	1.32	No	No	0	5	9
254	R:R:R653	R:R:S651	1.32	No	No	0	5	6
255	R:R:E604	R:R:N603	1.31	No	No	0	8	6
256	R:R:F755	R:R:L767	1.22	Yes	No	0	8	7
257	R:R:F758	R:R:L767	1.22	No	No	0	8	7
258	R:R:L789	R:R:R794	1.21	No	No	0	8	8
259	R:R:D541	R:R:R680	1.19	No	Yes	0	5	8
260	R:R:D687	R:R:R680	1.19	No	Yes	7	5	8
261	R:R:D687	R:R:F688	1.19	No	No	7	5	4
262	R:R:L765	R:R:Y540	1.17	No	No	0	3	6
263	R:R:L664	R:R:Y621	1.17	No	Yes	0	8	6
264	R:R:L765	R:R:Y769	1.17	No	Yes	0	3	9
265	R:R:E795	R:R:R798	1.16	No	No	0	6	4
266	R:R:Q690	R:R:Y674	1.13	No	Yes	0	2	5
267	R:R:R613	R:R:Y678	1.03	No	Yes	1	6	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F533	3.89	5	2	9
2	R:R:M537	3.325	4	2	9
3	R:R:H583	7.075	4	5	9
4	R:R:H585	7.39	4	3	9
5	R:R:I596	2.5525	4	0	6
6	R:R:H620	3.95	4	0	9
7	R:R:Y621	3.0575	4	0	6
8	R:R:W629	6.23875	8	3	9
9	R:R:E633	6.572	5	5	9
10	R:R:Y660	6.28	4	3	9
11	R:R:P663	2.974	5	0	9
12	R:R:Y674	6.92	4	1	5
13	R:R:Y678	2.93833	6	1	9
14	R:R:R680	4.8825	4	7	8
15	R:R:W685	5.655	4	0	9
16	R:R:F692	4.85	5	1	8
17	R:R:L697	3.855	4	2	7
18	R:R:F711	4.07	4	0	8
19	R:R:N726	4.43	4	8	8
20	R:R:I740	1.7225	4	0	7
21	R:R:F747	5.935	4	0	5
22	R:R:W753	6.35167	6	2	9
23	R:R:F755	2.5525	4	0	8
24	R:R:Y769	4.405	4	4	9
25	R:R:F771	4.908	5	2	9
26	R:R:N775	6.398	5	2	9
27	R:R:C776	2.8775	4	0	8
28	R:R:Y783	5.335	6	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I759	R:R:T768	10.8345	6.08	No	No	0	8	7
2	R:R:G756	R:R:I759	13.7813	3.53	No	No	0	9	8
3	R:R:F771	R:R:G756	15.2737	3.01	Yes	No	0	9	9
4	R:R:F533	R:R:L536	53.0801	4.87	Yes	No	0	9	9
5	R:R:L536	R:R:W685	55.1886	5.69	No	Yes	0	9	9
6	R:R:L619	R:R:W685	25.2826	3.42	No	Yes	0	9	9
7	R:R:F533	R:R:W753	51.5369	4.01	Yes	Yes	2	9	9
8	R:R:F533	R:R:N775	10.4598	2.42	Yes	Yes	2	9	9
9	R:R:C776	R:R:F533	34.2436	2.79	Yes	Yes	0	8	9
10	R:R:L686	R:R:L693	17.7188	2.77	No	No	0	9	7
11	R:R:L686	R:R:W685	26.3496	11.39	No	Yes	0	9	9
12	R:R:C776	R:R:T772	19.0144	1.69	Yes	No	0	8	9
13	R:R:L547	R:R:T772	14.6894	2.95	No	No	0	9	9
14	R:R:L547	R:R:Y769	13.2351	7.03	No	Yes	0	9	9
15	R:R:C776	R:R:T551	12.9493	5.07	Yes	No	0	8	9
16	R:R:L555	R:R:T551	11.3743	1.47	No	No	0	9	9
17	R:R:G779	R:R:L782	12.5683	3.42	No	No	0	9	8
18	R:R:L782	R:R:Q778	14.6196	3.99	No	No	0	8	9
19	R:R:F747	R:R:Q778	16.6582	2.34	Yes	No	0	5	9
20	R:R:F747	R:R:T752	24.6856	3.89	Yes	No	0	5	9
21	R:R:T752	R:R:W753	18.4872	2.43	No	Yes	2	9	9
22	R:R:C787	R:R:Y783	29.5313	6.72	No	Yes	0	9	9
23	R:R:C787	R:R:F569	49.4284	2.79	No	No	0	9	9
24	R:R:F569	R:R:H583	55.9444	6.79	No	Yes	0	9	9
25	R:R:E633	R:R:H583	50.3175	8.62	Yes	Yes	5	9	9
26	R:R:E633	R:R:I582	95.4274	6.83	Yes	No	0	9	8
27	R:R:I582	R:R:W629	100	7.05	No	Yes	0	8	9
28	R:R:L586	R:R:W629	76.9338	2.28	No	Yes	0	9	9
29	R:R:L586	R:R:M630	76.9211	2.83	No	No	0	9	9
30	R:R:F627	R:R:M630	76.8957	3.73	No	No	0	9	9
31	R:R:F627	R:R:W753	72.0437	14.03	No	Yes	0	9	9
32	R:R:C787	R:R:T568	18.6397	3.38	No	No	0	9	9
33	R:R:T568	R:R:Y797	17.1409	7.49	No	No	0	9	9
34	R:R:Y783	R:R:Y797	17.6299	1.99	Yes	No	0	9	9
35	R:R:I575	R:R:K792	22.3549	5.82	No	No	0	9	9
36	R:R:K792	R:R:N790	25.4985	4.2	No	No	0	9	9
37	R:R:N790	R:R:V793	28.6295	4.43	No	No	0	9	9
38	R:R:V793	R:R:Y797	31.735	7.57	No	No	0	9	9
39	R:R:I575	R:R:V572	19.1985	4.61	No	No	0	9	9
40	R:R:Y621	R:R:Y660	25.8351	2.98	Yes	Yes	0	6	9
41	R:R:P663	R:R:Y621	22.7867	5.56	Yes	Yes	0	9	6
42	R:R:P663	R:R:V662	37.5841	3.53	Yes	No	0	9	7
43	R:R:I666	R:R:V662	37.0443	3.07	No	No	0	8	7
44	R:R:I666	R:R:L624	35.5074	4.28	No	No	0	8	9
45	R:R:H620	R:R:L624	34.974	5.14	Yes	No	0	9	9
46	R:R:H620	R:R:W685	17.5664	2.12	Yes	Yes	0	9	9
47	R:R:E633	R:R:L748	33.6339	5.3	Yes	No	5	9	8
48	R:R:I596	R:R:L619	14.6831	4.28	Yes	No	0	6	9
49	R:R:G679	R:R:R613	11.0758	3	No	No	1	9	6
50	R:R:R613	R:R:Y678	15.4642	1.03	No	Yes	1	6	9
51	R:R:H620	R:R:Y678	30.8332	4.36	Yes	Yes	0	9	9
52	R:R:C628	R:R:P663	18.773	1.88	No	Yes	0	7	9
53	R:R:C628	R:R:G659	19.5034	1.96	No	No	0	7	9
54	R:R:L632	R:R:W629	18.3539	2.28	No	Yes	0	9	9
55	R:R:E633	R:R:G634	11.9522	1.64	Yes	No	0	9	9
56	R:R:G634	R:R:L749	10.282	1.71	No	No	0	9	9
57	R:R:F639	R:R:L635	11.7998	7.31	No	No	0	8	7
58	R:R:L632	R:R:L635	13.4574	1.38	No	No	0	9	7
59	R:R:F692	R:R:Y674	11.2727	3.09	Yes	Yes	1	8	5
60	R:R:F711	R:R:Q745	13.7178	2.34	Yes	No	0	8	9
61	R:R:A744	R:R:Q745	20.2591	3.03	No	No	0	9	9
62	R:R:A744	R:R:L785	21.8722	1.58	No	No	0	9	8
63	R:R:H786	R:R:L785	37.3047	2.57	No	No	0	9	8
64	R:R:H786	R:R:L748	38.74	12.86	No	No	0	9	8
65	R:R:I740	R:R:L785	15.388	1.43	Yes	No	0	7	8
66	R:R:W629	R:R:Y660	23.4218	11.58	Yes	Yes	3	9	9
67	R:R:G659	R:R:W629	20.2718	5.63	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7YDM_nogp

PDB Summary
PDB	7YDM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.84
Number of Linked Nodes	244
Number of Links	267
Number of Hubs	28
Number of Links mediated by Hubs	108
Number of Communities	8
Number of Nodes involved in Communities	40
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	33918
Length Of Smallest Path	3
Average Path Length	13.2731
Length of Longest Path	30
Minimum Path Strength	1.17
Average Path Strength	4.68206
Maximum Path Strength	14.295
Minimum Path Correlation	0.7
Average Path Correlation	0.933086
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	57.1805
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.6995
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• response to stimulus • immune response • immune system process • regulation of biological process • signaling • biological regulation • cell-cell signaling • cellular process • cell communication • cellular response to stimulus • regulation of cellular process • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell surface receptor signaling pathway • cell adhesion • defense response • response to stress • inflammatory response • cellular anatomical structure • anchoring junction • cell junction • focal adhesion • cell-substrate junction • membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle
Gene Ontology	Cellular Component	• cellular anatomical structure • anchoring junction • cell junction • focal adhesion • cell-substrate junction • membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cell periphery • plasma membrane • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • organelle membrane • secretory granule membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • synapse • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P48960
Sequence	>7YDM_nogp_Chain_R S S F A I L M A H Y D V E D W K L T L I T R V G L A L S L F C L L L C I L T F L L V R P I Q G S R T T I H L H L C I C L F V G S T I F L A G I E N E G G Q V G L R C R L V A G L L H Y C F L A A F C W M S L E G L E L Y F L V V R V F Q G Q G L S T R W L C L I G Y G V P L L I V G V S A A I Y S K G Y G R P R Y C W L D F E Q G F L W S F L G P V T F I I L C N A V I F V T T V W K L T Q K F S E I N P D M K K L K K A R A L T I T A I A Q L F L L G C T W V F G L F I F D D R S L V L T Y V F T I L N C L Q G A F L Y L L H C L L N K K V R E E Y R K W A C L V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YDH	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi2-G13)/β1/γ2	3.1	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	7YDH (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		3.1	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	7YDM	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.89	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	7YDM (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		2.89	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	7YDP	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	7YDP (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		3.1	2023-07-12	doi.org/10.1016/j.chembiol.2023.08.003
	8IKL	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi1L-G13)/β1/γ2	2.33	2024-01-24	doi.org/10.1016/j.molcel.2023.12.020
	8IKL (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		2.33	2024-01-24	doi.org/10.1016/j.molcel.2023.12.020
	8IKJ	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	-	3.2	2024-02-14	doi.org/10.1016/j.molcel.2023.12.020
	7YDJ	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi1-G12)/β1/γ2	3.03	2023-07-12	To be published
	7YDJ (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		3.03	2023-07-12	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7YDM_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.