psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E602	R:R:S531	2.87	No	No	0	7	9
2	R:R:S531	R:R:Y683	6.36	No	Yes	0	9	6
3	R:R:L547	R:R:S532	4.5	Yes	No	0	9	9
4	R:R:S532	R:R:T551	6.4	No	No	0	9	9
5	R:R:F533	R:R:T551	5.19	Yes	No	6	9	9
6	R:R:F533	R:R:L555	6.09	Yes	No	6	9	9
7	R:R:F533	R:R:F597	3.22	Yes	No	0	9	9
8	R:R:C776	R:R:F533	5.59	No	Yes	0	8	9
9	R:R:A534	R:R:T772	3.36	No	No	0	9	9
10	R:R:I535	R:R:I601	2.94	No	No	0	8	7
11	R:R:F597	R:R:L536	3.65	No	No	0	9	9
12	R:R:F623	R:R:L536	4.87	No	No	0	8	9
13	R:R:L536	R:R:W685	11.39	No	Yes	0	9	9
14	R:R:L697	R:R:M537	2.83	Yes	No	0	7	9
15	R:R:F771	R:R:M537	6.22	Yes	No	0	9	9
16	R:R:H539	R:R:L693	11.57	No	No	0	6	7
17	R:R:H539	R:R:L697	3.86	No	Yes	0	6	7
18	R:R:V542	R:R:Y540	16.4	No	No	0	6	6
19	R:R:D541	R:R:R680	3.57	No	Yes	3	5	8
20	R:R:D541	R:R:R682	7.15	No	No	3	5	4
21	R:R:D541	R:R:Y683	8.05	No	Yes	3	5	6
22	R:R:E543	R:R:R682	5.82	No	No	0	5	4
23	R:R:D544	R:R:W545	5.58	No	No	4	8	5
24	R:R:D544	R:R:K546	5.53	No	No	4	8	4
25	R:R:D544	R:R:Y769	3.45	No	Yes	4	8	9
26	R:R:K546	R:R:W545	8.12	No	No	4	4	5
27	R:R:K546	R:R:Y769	5.97	No	Yes	4	4	9
28	R:R:L547	R:R:T768	2.95	Yes	No	0	9	7
29	R:R:L547	R:R:Y769	10.55	Yes	Yes	0	9	9
30	R:R:L547	R:R:T772	2.95	Yes	No	0	9	9
31	R:R:I550	R:R:T772	3.04	No	No	0	8	9
32	R:R:I550	R:R:I773	2.94	No	No	0	8	8
33	R:R:L555	R:R:T551	2.95	No	No	6	9	9
34	R:R:L555	R:R:S594	7.51	No	No	0	9	8
35	R:R:L562	R:R:S558	3	Yes	No	0	9	9
36	R:R:F591	R:R:L559	7.31	No	Yes	7	9	8
37	R:R:L559	R:R:S594	7.51	Yes	No	0	8	8
38	R:R:L559	R:R:T595	2.95	Yes	No	7	8	6
39	R:R:A780	R:R:C561	3.61	No	No	0	5	9
40	R:R:C587	R:R:L562	3.17	No	Yes	0	8	9
41	R:R:L562	R:R:L590	4.15	Yes	No	0	9	9
42	R:R:G779	R:R:L562	3.42	No	Yes	0	9	9
43	R:R:F591	R:R:L563	7.31	No	No	0	9	5
44	R:R:L564	R:R:Y783	5.86	No	Yes	0	8	9
45	R:R:C565	R:R:Y783	6.72	No	Yes	0	7	9
46	R:R:I566	R:R:L570	2.85	Yes	No	5	9	6
47	R:R:I566	R:R:L584	2.85	Yes	No	5	9	9
48	R:R:C587	R:R:I566	3.27	No	Yes	0	8	9
49	R:R:I566	R:R:I588	5.89	Yes	No	5	9	7
50	R:R:T568	R:R:Y797	8.74	No	Yes	0	9	9
51	R:R:F569	R:R:H583	5.66	No	Yes	0	9	9
52	R:R:C787	R:R:F569	4.19	No	No	0	9	9
53	R:R:L570	R:R:L584	4.15	No	No	5	6	9
54	R:R:L571	R:R:W800	5.69	No	No	0	7	6
55	R:R:I575	R:R:V572	3.07	No	No	0	9	9
56	R:R:E796	R:R:V572	5.7	No	No	0	8	9
57	R:R:P574	R:R:R573	2.88	No	No	0	8	8
58	R:R:Q576	R:R:R573	9.35	No	No	0	8	8
59	R:R:E796	R:R:P574	7.86	No	No	0	8	8
60	R:R:I575	R:R:T580	3.04	No	No	0	9	9
61	R:R:E636	R:R:S578	7.19	No	No	0	7	8
62	R:R:H583	R:R:R579	4.51	Yes	No	0	9	9
63	R:R:I582	R:R:W629	4.7	No	Yes	2	8	9
64	R:R:I582	R:R:L632	2.85	No	No	2	8	9
65	R:R:E633	R:R:I582	8.2	No	No	2	9	8
66	R:R:E633	R:R:H583	9.85	No	Yes	2	9	9
67	R:R:H583	R:R:L748	6.43	Yes	No	2	9	8
68	R:R:I588	R:R:L584	2.85	No	No	5	7	9
69	R:R:H585	R:R:W629	27.51	Yes	Yes	2	9	9
70	R:R:C656	R:R:H585	2.95	No	Yes	0	4	9
71	R:R:H585	R:R:Y660	8.71	Yes	Yes	2	9	9
72	R:R:L586	R:R:L590	4.15	No	No	0	9	9
73	R:R:L586	R:R:M630	4.24	No	No	0	9	9
74	R:R:F591	R:R:T595	3.89	No	No	7	9	6
75	R:R:I596	R:R:V592	3.07	No	No	0	6	6
76	R:R:C622	R:R:G593	3.92	No	No	0	7	9
77	R:R:I596	R:R:L619	4.28	No	No	0	6	9
78	R:R:F597	R:R:I601	7.54	No	No	0	9	7
79	R:R:C612	R:R:N603	4.72	Yes	No	8	9	6
80	R:R:C684	R:R:N603	4.72	No	No	8	9	6
81	R:R:C612	R:R:V608	3.42	Yes	No	0	9	6
82	R:R:R613	R:R:V608	3.92	No	No	0	6	6
83	R:R:L610	R:R:L614	5.54	No	No	0	6	5
84	R:R:C612	R:R:C684	7.28	Yes	No	8	9	9
85	R:R:R613	R:R:Y678	4.12	No	Yes	0	6	9
86	R:R:C684	R:R:V615	3.42	No	No	0	9	8
87	R:R:G617	R:R:Y678	2.9	No	Yes	0	8	9
88	R:R:L619	R:R:W685	3.42	No	Yes	0	9	9
89	R:R:H620	R:R:L624	5.14	No	Yes	0	9	9
90	R:R:H620	R:R:V667	5.54	No	No	0	9	9
91	R:R:H620	R:R:S695	5.58	No	No	0	9	8
92	R:R:Y621	R:R:Y660	2.98	No	Yes	0	6	9
93	R:R:P663	R:R:Y621	5.56	Yes	No	0	9	6
94	R:R:L624	R:R:P663	3.28	Yes	Yes	0	9	9
95	R:R:I666	R:R:L624	4.28	No	Yes	0	8	9
96	R:R:L624	R:R:P699	3.28	Yes	No	0	9	9
97	R:R:F627	R:R:V700	13.11	No	No	0	9	8
98	R:R:F627	R:R:W753	4.01	No	Yes	0	9	9
99	R:R:C628	R:R:P663	3.77	No	Yes	0	7	9
100	R:R:L632	R:R:W629	3.42	No	Yes	2	9	9
101	R:R:G659	R:R:W629	7.04	No	Yes	0	9	9
102	R:R:W629	R:R:Y660	11.58	Yes	Yes	2	9	9
103	R:R:G750	R:R:M630	3.49	No	No	0	9	9
104	R:R:I703	R:R:S631	3.1	No	No	0	9	7
105	R:R:L632	R:R:L655	4.15	No	No	0	9	7
106	R:R:E633	R:R:L748	10.6	No	No	2	9	8
107	R:R:F639	R:R:L635	3.65	Yes	No	0	8	7
108	R:R:I710	R:R:L637	4.28	No	Yes	0	7	9
109	R:R:L637	R:R:T714	2.95	Yes	No	0	9	9
110	R:R:F639	R:R:Y638	6.19	Yes	No	0	8	8
111	R:R:V642	R:R:Y638	17.66	No	No	0	9	8
112	R:R:F639	R:R:R643	7.48	Yes	No	0	8	7
113	R:R:Q648	R:R:R643	14.02	No	No	0	7	7
114	R:R:G647	R:R:Q648	4.93	No	No	0	5	7
115	R:R:L650	R:R:L655	5.54	No	No	0	5	7
116	R:R:S651	R:R:W654	4.94	No	No	0	6	6
117	R:R:P663	R:R:V662	3.53	Yes	No	0	9	7
118	R:R:I666	R:R:V662	3.07	No	No	0	8	7
119	R:R:I673	R:R:V669	3.07	No	No	0	5	7
120	R:R:S670	R:R:Y678	3.82	No	Yes	9	9	9
121	R:R:F692	R:R:S670	7.93	Yes	No	9	8	9
122	R:R:S670	R:R:S695	4.89	No	No	0	9	8
123	R:R:K676	R:R:Y674	5.97	No	Yes	0	3	5
124	R:R:G677	R:R:Y674	7.24	No	Yes	0	8	5
125	R:R:Q690	R:R:Y674	19.16	No	Yes	0	2	5
126	R:R:F692	R:R:G677	3.01	Yes	No	0	8	8
127	R:R:F692	R:R:Y678	6.19	Yes	Yes	9	8	9
128	R:R:P681	R:R:R680	2.88	No	Yes	0	3	8
129	R:R:R680	R:R:Y683	4.12	Yes	Yes	3	8	6
130	R:R:F688	R:R:R680	12.83	No	Yes	0	4	8
131	R:R:R682	R:R:Y683	5.14	No	Yes	3	4	6
132	R:R:L686	R:R:W685	10.25	No	Yes	0	9	9
133	R:R:F696	R:R:W685	3.01	No	Yes	0	9	9
134	R:R:F692	R:R:L686	6.09	Yes	No	0	8	9
135	R:R:L686	R:R:S695	3	No	No	0	9	8
136	R:R:D687	R:R:E689	3.9	No	No	0	5	3
137	R:R:L697	R:R:W694	5.69	Yes	No	0	7	8
138	R:R:F696	R:R:V700	3.93	No	No	0	9	8
139	R:R:G698	R:R:P699	4.06	No	No	0	8	9
140	R:R:L757	R:R:T701	2.95	No	No	0	5	7
141	R:R:I703	R:R:N707	2.83	No	No	0	9	9
142	R:R:L749	R:R:N707	15.1	No	No	0	9	9
143	R:R:F711	R:R:V715	3.93	Yes	No	0	8	6
144	R:R:K717	R:R:T713	3	No	No	0	8	6
145	R:R:Q720	R:R:W716	8.76	No	No	0	5	8
146	R:R:L738	R:R:T719	4.42	No	No	0	9	8
147	R:R:F722	R:R:N726	10.87	Yes	No	0	8	8
148	R:R:F722	R:R:M729	3.73	Yes	No	0	8	7
149	R:R:F722	R:R:K734	9.93	Yes	No	0	8	7
150	R:R:A737	R:R:F722	5.55	No	Yes	0	6	8
151	R:R:I725	R:R:N726	2.83	No	No	0	8	8
152	R:R:D728	R:R:P727	3.22	No	No	0	8	6
153	R:R:D728	R:R:M729	6.93	No	No	0	8	7
154	R:R:K733	R:R:M729	8.64	No	No	0	5	7
155	R:R:K731	R:R:L732	2.82	No	No	0	6	8
156	R:R:K734	R:R:L738	4.23	No	No	0	7	9
157	R:R:I740	R:R:L789	2.85	No	No	0	7	8
158	R:R:A744	R:R:L785	6.3	No	Yes	0	9	8
159	R:R:F747	R:R:T752	7.78	No	Yes	1	5	9
160	R:R:F747	R:R:Q778	8.2	No	No	1	5	9
161	R:R:F747	R:R:F781	13.93	No	No	0	5	8
162	R:R:H786	R:R:L748	10.29	No	No	0	9	8
163	R:R:G750	R:R:W753	2.81	No	Yes	0	9	9
164	R:R:T752	R:R:W753	3.64	Yes	Yes	1	9	9
165	R:R:L774	R:R:T752	4.42	No	Yes	0	7	9
166	R:R:N775	R:R:T752	5.85	No	Yes	1	9	9
167	R:R:Q778	R:R:T752	2.83	No	Yes	1	9	9
168	R:R:F771	R:R:W753	3.01	Yes	Yes	1	9	9
169	R:R:N775	R:R:W753	16.95	No	Yes	1	9	9
170	R:R:F755	R:R:V770	3.93	No	No	0	8	6
171	R:R:G756	R:R:I759	3.53	No	Yes	1	9	8
172	R:R:F771	R:R:G756	6.02	Yes	No	1	9	9
173	R:R:I759	R:R:T768	13.68	Yes	No	0	8	7
174	R:R:F771	R:R:I759	3.77	Yes	Yes	1	9	8
175	R:R:D761	R:R:D762	6.65	No	No	0	4	5
176	R:R:D761	R:R:R763	21.44	No	No	0	4	4
177	R:R:L765	R:R:Y769	3.52	No	Yes	0	3	9
178	R:R:F771	R:R:N775	7.25	Yes	No	1	9	9
179	R:R:L782	R:R:Q778	5.32	No	No	0	8	9
180	R:R:G779	R:R:L782	5.13	No	No	0	9	8
181	R:R:C787	R:R:Y783	16.13	No	Yes	0	9	9
182	R:R:L788	R:R:Y783	9.38	No	Yes	0	8	9
183	R:R:Y783	R:R:Y797	4.96	Yes	Yes	0	9	9
184	R:R:H786	R:R:L785	3.86	No	Yes	0	9	8
185	R:R:K792	R:R:N790	2.8	No	No	0	9	9
186	R:R:N790	R:R:V793	7.39	No	No	0	9	9
187	R:R:K791	R:R:R794	6.19	No	No	0	8	8
188	R:R:E795	R:R:K792	4.05	No	No	0	6	9
189	R:R:V793	R:R:Y797	6.31	No	Yes	0	9	9
190	R:R:R794	R:R:R798	3.2	No	No	0	8	4
191	R:R:E795	R:R:R798	3.49	No	No	0	6	4
192	R:R:W800	R:R:Y797	6.75	No	Yes	0	6	9
193	R:R:L803	R:R:V804	4.47	No	No	0	4	5
194	R:R:C706	R:R:F702	2.79	No	No	0	5	4
195	R:R:A742	R:R:F711	2.77	No	Yes	0	9	8
196	R:R:H585	R:R:T581	2.74	Yes	No	0	9	9
197	R:R:C589	R:R:Y660	2.69	No	Yes	0	8	9
198	R:R:A616	R:R:Y678	2.67	No	Yes	0	9	9
199	R:R:L637	R:R:Q745	2.66	Yes	No	0	9	9
200	R:R:E604	R:R:N603	2.63	No	No	0	8	6
201	R:R:E689	R:R:Q690	2.55	No	No	0	3	2
202	R:R:F627	R:R:I703	2.51	No	No	0	9	9
203	R:R:V572	R:R:W800	2.45	No	No	0	9	6
204	R:R:F688	R:R:L693	2.44	No	No	0	4	7
205	R:R:F711	R:R:L746	2.44	Yes	No	0	8	7
206	R:R:F758	R:R:L767	2.44	No	No	0	8	7
207	R:R:I759	R:R:Y540	2.42	Yes	No	0	8	6
208	R:R:I710	R:R:Y638	2.42	No	No	0	7	8
209	R:R:L664	R:R:Y621	2.34	No	No	0	8	6
210	R:R:F711	R:R:Q745	2.34	Yes	No	0	8	9
211	R:R:E636	R:R:F639	2.33	No	Yes	0	7	8
212	R:R:D762	R:R:Y540	2.3	No	No	0	5	6
213	R:R:L650	R:R:W654	2.28	No	No	0	5	6
214	R:R:G605	R:R:G606	2.11	No	No	0	7	6
215	R:R:G661	R:R:P663	2.03	No	Yes	0	9	9
216	R:R:R653	R:R:W654	2	No	No	0	5	6
217	R:R:C776	R:R:G554	1.96	No	No	0	8	9
218	R:R:C612	R:R:G679	1.96	Yes	No	0	9	9
219	R:R:A599	R:R:G600	1.95	No	No	0	6	8
220	R:R:A625	R:R:P663	1.87	No	Yes	0	9	9
221	R:R:G554	R:R:V553	1.84	No	No	0	9	7
222	R:R:G593	R:R:V592	1.84	No	No	0	9	6
223	R:R:G609	R:R:V608	1.84	No	No	0	5	6
224	R:R:G668	R:R:V667	1.84	No	No	0	6	9
225	R:R:A626	R:R:C589	1.81	No	No	0	8	8
226	R:R:G554	R:R:L777	1.71	No	No	0	9	8
227	R:R:G634	R:R:L637	1.71	No	Yes	0	9	9
228	R:R:G634	R:R:L749	1.71	No	No	0	9	9
229	R:R:A538	R:R:V542	1.7	No	No	0	9	6
230	R:R:C656	R:R:T652	1.69	No	No	0	4	6
231	R:R:G577	R:R:Q576	1.64	No	No	0	8	8
232	R:R:G606	R:R:Q607	1.64	No	No	0	6	4
233	R:R:G649	R:R:Q648	1.64	No	No	0	7	7
234	R:R:C751	R:R:I704	1.64	No	No	0	5	6
235	R:R:S531	R:R:T548	1.6	No	No	0	9	4
236	R:R:S532	R:R:T548	1.6	No	No	0	9	4
237	R:R:V766	R:R:V770	1.6	No	No	0	6	6
238	R:R:T714	R:R:V641	1.59	No	No	0	9	9
239	R:R:C751	R:R:L746	1.59	No	No	0	5	7
240	R:R:C751	R:R:L749	1.59	No	No	0	5	9
241	R:R:I704	R:R:V754	1.54	No	No	0	6	6
242	R:R:K717	R:R:V641	1.52	No	No	0	8	9
243	R:R:I743	R:R:T739	1.52	No	No	0	6	9
244	R:R:I740	R:R:T741	1.52	No	No	0	7	9
245	R:R:F755	R:R:G756	1.51	No	No	0	8	9
246	R:R:L640	R:R:V641	1.49	No	No	0	6	9
247	R:R:L705	R:R:T701	1.47	No	No	0	5	7
248	R:R:L718	R:R:T741	1.47	No	No	0	8	9
249	R:R:D761	R:R:S764	1.47	No	No	0	4	7
250	R:R:I725	R:R:K721	1.45	No	No	0	8	9
251	R:R:E724	R:R:S723	1.44	No	No	0	8	8
252	R:R:I740	R:R:L785	1.43	No	Yes	0	7	8
253	R:R:I743	R:R:L785	1.43	No	Yes	0	6	8
254	R:R:G691	R:R:W694	1.41	No	No	0	6	8
255	R:R:C561	R:R:F560	1.4	No	No	0	9	5
256	R:R:L557	R:R:L777	1.38	No	No	0	6	8
257	R:R:L559	R:R:L598	1.38	Yes	No	0	8	9
258	R:R:L697	R:R:L757	1.38	Yes	No	0	7	5
259	R:R:L718	R:R:L738	1.38	No	No	0	8	9
260	R:R:L784	R:R:L788	1.38	No	No	0	5	8
261	R:R:R552	R:R:T548	1.29	No	No	0	5	4
262	R:R:F560	R:R:L564	1.22	No	No	0	5	8
263	R:R:F755	R:R:L767	1.22	No	No	0	8	7
264	R:R:F758	R:R:L757	1.22	No	No	0	8	5
265	R:R:L549	R:R:R552	1.21	No	No	0	5	5
266	R:R:I673	R:R:Y674	1.21	No	Yes	0	5	5
267	R:R:T719	R:R:W716	1.21	No	No	0	8	8
268	R:R:E604	R:R:R611	1.16	No	No	0	8	7
269	R:R:F760	R:R:H539	1.13	No	No	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F533	5.0225	4	6	9
2	R:R:L547	5.2375	4	0	9
3	R:R:L559	4.7875	4	7	8
4	R:R:L562	3.435	4	0	9
5	R:R:I566	3.715	4	5	9
6	R:R:H583	6.6125	4	2	9
7	R:R:H585	10.4775	4	2	9
8	R:R:C612	4.345	4	8	9
9	R:R:L624	3.995	4	0	9
10	R:R:W629	10.85	5	2	9
11	R:R:L637	2.9	4	0	9
12	R:R:F639	4.9125	4	0	8
13	R:R:Y660	6.49	4	2	9
14	R:R:P663	3.34	6	0	9
15	R:R:Y674	8.395	4	0	5
16	R:R:Y678	3.94	5	9	9
17	R:R:R680	5.85	4	3	8
18	R:R:Y683	5.9175	4	3	6
19	R:R:W685	7.0175	4	0	9
20	R:R:F692	5.805	4	9	8
21	R:R:L697	3.44	4	0	7
22	R:R:F711	2.87	4	0	8
23	R:R:F722	7.52	4	0	8
24	R:R:T752	4.904	5	1	9
25	R:R:W753	6.084	5	1	9
26	R:R:I759	5.85	4	1	8
27	R:R:Y769	5.8725	4	4	9
28	R:R:F771	5.254	5	1	9
29	R:R:Y783	8.61	5	0	9
30	R:R:L785	3.255	4	0	8
31	R:R:Y797	6.69	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S531	R:R:T548	12.5611	1.6	No	No	0	9	4
2	R:R:S532	R:R:T548	16.9967	1.6	No	No	0	9	4
3	R:R:L547	R:R:S532	23.8236	4.5	Yes	No	0	9	9
4	R:R:S532	R:R:T551	29.3327	6.4	No	No	0	9	9
5	R:R:F533	R:R:T551	25.3986	5.19	Yes	No	6	9	9
6	R:R:F533	R:R:F597	35.8833	3.22	Yes	No	0	9	9
7	R:R:F597	R:R:L536	38.1911	3.65	No	No	0	9	9
8	R:R:L536	R:R:W685	40.0553	11.39	No	Yes	0	9	9
9	R:R:H539	R:R:L697	10.8447	3.86	No	Yes	0	6	7
10	R:R:L697	R:R:M537	20.5516	2.83	Yes	No	0	7	9
11	R:R:L547	R:R:T768	20.0759	2.95	Yes	No	0	9	7
12	R:R:I759	R:R:T768	20.4423	13.68	Yes	No	0	8	7
13	R:R:F771	R:R:I759	27.5392	3.77	Yes	Yes	1	9	8
14	R:R:F771	R:R:M537	22.0044	6.22	Yes	No	0	9	9
15	R:R:I759	R:R:Y540	11.6482	2.42	Yes	No	0	8	6
16	R:R:F771	R:R:W753	45.5901	3.01	Yes	Yes	1	9	9
17	R:R:G750	R:R:W753	16.6945	2.81	No	Yes	0	9	9
18	R:R:G750	R:R:M630	15.2096	3.49	No	No	0	9	9
19	R:R:L586	R:R:M630	13.7246	4.24	No	No	0	9	9
20	R:R:L586	R:R:L590	12.2397	4.15	No	No	0	9	9
21	R:R:L562	R:R:L590	10.7868	4.15	Yes	No	0	9	9
22	R:R:T752	R:R:W753	21.1815	3.64	Yes	Yes	1	9	9
23	R:R:Q778	R:R:T752	19.7801	2.83	No	Yes	1	9	9
24	R:R:L782	R:R:Q778	17.9866	5.32	No	No	0	8	9
25	R:R:G779	R:R:L782	16.0517	5.13	No	No	0	9	8
26	R:R:G779	R:R:L562	14.1167	3.42	No	Yes	0	9	9
27	R:R:C787	R:R:Y783	40.2031	16.13	No	Yes	0	9	9
28	R:R:C787	R:R:F569	41.5145	4.19	No	No	0	9	9
29	R:R:F569	R:R:H583	42.8131	5.66	No	Yes	0	9	9
30	R:R:E633	R:R:H583	40.6146	9.85	No	Yes	2	9	9
31	R:R:E633	R:R:I582	72.8979	8.2	No	No	2	9	8
32	R:R:I582	R:R:W629	71.638	4.7	No	Yes	2	8	9
33	R:R:W629	R:R:Y660	79.2106	11.58	Yes	Yes	2	9	9
34	R:R:Y621	R:R:Y660	86.3718	2.98	No	Yes	0	6	9
35	R:R:P663	R:R:Y621	87.8246	5.56	Yes	No	0	9	6
36	R:R:L624	R:R:P663	90.7174	3.28	Yes	Yes	0	9	9
37	R:R:H620	R:R:L624	94.2659	5.14	No	Yes	0	9	9
38	R:R:H620	R:R:S695	95.918	5.58	No	No	0	9	8
39	R:R:L686	R:R:S695	84.3597	3	No	No	0	9	8
40	R:R:L686	R:R:W685	100	10.25	No	Yes	0	9	9
41	R:R:C587	R:R:L562	17.7359	3.17	No	Yes	0	8	9
42	R:R:C587	R:R:I566	14.2132	3.27	No	Yes	0	8	9
43	R:R:Y783	R:R:Y797	29.2235	4.96	Yes	Yes	0	9	9
44	R:R:W800	R:R:Y797	15.9617	6.75	No	Yes	0	6	9
45	R:R:V572	R:R:W800	12.8696	2.45	No	No	0	9	6
46	R:R:F627	R:R:W753	62.1432	4.01	No	Yes	0	9	9
47	R:R:F627	R:R:I703	43.2373	2.51	No	No	0	9	9
48	R:R:I703	R:R:N707	40.7046	2.83	No	No	0	9	9
49	R:R:L749	R:R:N707	39.4189	15.1	No	No	0	9	9
50	R:R:G634	R:R:L749	28.2335	1.71	No	No	0	9	9
51	R:R:G634	R:R:L637	26.8707	1.71	No	Yes	0	9	9
52	R:R:I710	R:R:L637	17.2474	4.28	No	Yes	0	7	9
53	R:R:I710	R:R:Y638	15.7431	2.42	No	No	0	7	8
54	R:R:F639	R:R:Y638	12.6961	6.19	Yes	No	0	8	8
55	R:R:E633	R:R:L748	31.3255	10.6	No	No	2	9	8
56	R:R:C612	R:R:V608	10.9283	3.42	Yes	No	0	9	6
57	R:R:R613	R:R:V608	13.9367	3.92	No	No	0	6	6
58	R:R:R613	R:R:Y678	15.4217	4.12	No	Yes	0	6	9
59	R:R:F692	R:R:Y678	12.3618	6.19	Yes	Yes	9	8	9
60	R:R:F692	R:R:L686	25.6364	6.09	Yes	No	0	8	9
61	R:R:F627	R:R:V700	73.2065	13.11	No	No	0	9	8
62	R:R:F696	R:R:W685	73.7529	3.01	No	Yes	0	9	9
63	R:R:F696	R:R:V700	73.3801	3.93	No	No	0	9	8
64	R:R:F692	R:R:G677	16.9645	3.01	Yes	No	0	8	8
65	R:R:G677	R:R:Y674	14.8881	7.24	No	Yes	0	8	5
66	R:R:S670	R:R:S695	13.8917	4.89	No	No	0	9	8
67	R:R:C751	R:R:L749	10.5876	1.59	No	No	0	5	9
68	R:R:H786	R:R:L748	34.7197	10.29	No	No	0	9	8
69	R:R:H786	R:R:L785	33.3762	3.86	No	Yes	0	9	8
70	R:R:I740	R:R:L785	27.7771	1.43	No	Yes	0	7	8
71	R:R:I740	R:R:T741	24.9357	1.52	No	No	0	7	9
72	R:R:L718	R:R:T741	23.4636	1.47	No	No	0	8	9
73	R:R:L718	R:R:L738	22.0237	1.38	No	No	0	8	9
74	R:R:K734	R:R:L738	15.9874	4.23	No	No	0	7	9
75	R:R:F722	R:R:K734	14.4317	9.93	Yes	No	0	8	7
76	R:R:V793	R:R:Y797	11.3075	6.31	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7YDH_nogp

PDB Summary
PDB	7YDH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.8
Number of Linked Nodes	253
Number of Links	269
Number of Hubs	31
Number of Links mediated by Hubs	121
Number of Communities	9
Number of Nodes involved in Communities	40
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	32885
Length Of Smallest Path	3
Average Path Length	16.0599
Length of Longest Path	37
Minimum Path Strength	1.25
Average Path Strength	5.40523
Maximum Path Strength	17.275
Minimum Path Correlation	0.7
Average Path Correlation	0.940881
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	51.9452
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.05
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • D5 dopamine receptor binding • dopamine receptor binding • enzyme regulator activity • hydrolase activity • GDP binding • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides • catalytic activity • pyrophosphatase activity • GTPase activity • nucleoside-triphosphatase regulator activity • GTPase regulator activity • guanyl-nucleotide exchange factor activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • G protein activity • cation binding • metal ion binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • blood circulation • developmental process • cellular developmental process • cell differentiation • cellular process • cellular response to stimulus • regulation of biological process
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • blood circulation • developmental process • cellular developmental process • cell differentiation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of vascular associated smooth muscle cell migration • negative regulation of locomotion • vascular associated smooth muscle cell migration • regulation of cell motility • negative regulation of vascular associated smooth muscle cell migration • regulation of smooth muscle cell migration • negative regulation of biological process • smooth muscle cell migration • muscle cell migration • negative regulation of smooth muscle cell migration • regulation of locomotion • regulation of cell migration • negative regulation of cellular process • negative regulation of cell motility • cell migration • cell motility • locomotion • negative regulation of cell migration • regulation of fibroblast migration • fibroblast migration • ameboidal-type cell migration • multicellular organism development • embryo development ending in birth or egg hatching • chordate embryonic development • anatomical structure development • embryo development • in utero embryonic development • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of developmental process • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • branching morphogenesis of an epithelial tube • angiogenesis • tube morphogenesis • epithelial tube morphogenesis • blood vessel development • system development • epithelium development • blood vessel morphogenesis • tube development • morphogenesis of an epithelium • tissue development • vasculature development • circulatory system development • branching involved in blood vessel morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • anatomical structure formation involved in morphogenesis • morphogenesis of a branching epithelium • regulation of cellular component organization • cellular component organization • cellular component biogenesis • cellular component assembly • regulation of postsynapse assembly • cell junction assembly • regulation of synapse structure or activity • synapse organization • cellular component organization or biogenesis • regulation of synapse assembly • postsynapse organization • postsynapse assembly • regulation of postsynapse organization • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • Rho-activating G protein-coupled receptor signaling pathway • regulation of signaling • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • regulation of signal transduction • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • intracellular signaling cassette • regulation of cell communication • Rho protein signal transduction • regulation of vascular associated smooth muscle cell proliferation • negative regulation of cell population proliferation • cell population proliferation • regulation of smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell proliferation • smooth muscle cell proliferation • negative regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cellular anatomical structure • anchoring junction • cell junction • focal adhesion • cell-substrate junction • membrane • membrane-bounded organelle • intracellular anatomical structure • pigment granule • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • melanosome • cytoplasmic vesicle
Gene Ontology	Cellular Component	• cellular anatomical structure • anchoring junction • cell junction • focal adhesion • cell-substrate junction • membrane • membrane-bounded organelle • intracellular anatomical structure • pigment granule • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • melanosome • cytoplasmic vesicle • organelle • cytoplasm • vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • cytosol • brush border membrane • cluster of actin-based cell projections • plasma membrane bounded cell projection • brush border • cell projection • plasma membrane region • cell projection membrane • postsynapse • synapse • nucleus • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • cation binding • ion binding • calcium ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • immune response • immune system process • cell surface receptor signaling pathway • cell adhesion • defense response • response to stress • inflammatory response • endomembrane system • cytoplasmic vesicle membrane • vesicle membrane • secretory granule • secretory vesicle • secretory granule membrane
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P48960
Sequence	>7YDH_nogp_Chain_R S S F A I L M A H Y D V E D W K L T L I T R V G L A L S L F C L L L C I L T F L L V R P I Q G S R T T I H L H L C I C L F V G S T I F L A G I E N E G G Q V G L R C R L V A G L L H Y C F L A A F C W M S L E G L E L Y F L V V R V F Q G Q G L S T R W L C L I G Y G V P L L I V G V S A A I Y S K G Y G R P R Y C W L D F E Q G F L W S F L G P V T F I I L C N A V I F V T T V W K L T Q K F S E I N P D M K K L K K A R A L T I T A I A Q L F L L G C T W V F G L F I F D D R S L V L T Y V F T I L N C L Q G A F L Y L L H C L L N K K V R E E Y R K W A C L V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IKJ	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	-	3.2	2024-02-14	10.1016/j.molcel.2023.12.020
	8IKL	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi1L-G13)/β1/γ2	2.33	2024-01-24	10.1016/j.molcel.2023.12.020
	8IKL (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		2.33	2024-01-24	10.1016/j.molcel.2023.12.020
	7YDJ	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi1-G12)/β1/γ2	3.03	2023-07-12	To be published
	7YDJ (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		3.03	2023-07-12	To be published
	7YDM	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.89	2023-07-12	10.1016/j.chembiol.2023.08.003
	7YDM (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		2.89	2023-07-12	10.1016/j.chembiol.2023.08.003
	7YDP	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-07-12	10.1016/j.chembiol.2023.08.003
	7YDP (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		3.1	2023-07-12	10.1016/j.chembiol.2023.08.003
	7YDH	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-	chim(NtGi2-G13)/β1/γ2	3.1	2023-07-12	10.1016/j.chembiol.2023.08.003
	7YDH (No Gprot)	B2	Adhesion	Adhesion	ADGRE5	Homo sapiens	-	-		3.1	2023-07-12	10.1016/j.chembiol.2023.08.003

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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