Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 5.06254134
2A:A:H41 3.5725496
3A:A:L46 4408
4A:A:S51 3.85754249
5A:A:K53 4.46754249
6A:A:T55 3.1175409
7A:A:F212 6.5525409
8A:A:V214 4.40754196
9A:A:F219 5.3875498
10A:A:Q227 2.808569
11A:A:K233 4.95569
12A:A:F238 6.805469
13A:A:N239 4.65754148
14A:A:Y253 7.7385158
15A:A:L270 3.8675406
16A:A:F273 5.7075439
17A:A:W277 5.55857736
18A:A:W281 5.306676145
19A:A:I288 5.63667689
20A:A:L289 4.75439
21A:A:F290 4.48333689
22A:A:L291 3.09438
23A:A:L296 5.28406
24A:A:I308 4.54254157
25A:A:Y311 6.16254156
26A:A:F312 3.04254158
27A:A:Y318 6.495406
28A:A:P321 4.05333635
29A:A:E330 7.4575433
30A:A:D331 7.29404
31A:A:T335 5.0675434
32A:A:Y339 6.696533
33A:A:R342 5.24534
34A:A:F345 4.23538
35A:A:L346 4.2025434
36A:A:C359 3.576535
37A:A:Y360 8.2775408
38A:A:F363 6.13435
39A:A:T364 6.6225489
40A:A:D368 7.4489
41A:A:N371 7.312589
42A:A:R374 8.138584
43A:A:F376 8.7754198
44A:A:I383 3.035498
45B:B:R22 6.2875476
46B:B:L51 4.8375409
47B:B:H54 6.376676139
48B:B:K57 10.66254149
49B:B:Y59 7.665408
50B:B:M61 3.022546
51B:B:W63 4.85833647
52B:B:R68 10.645445
53B:B:D76 4.088336139
54B:B:K78 5.5154138
55B:B:W82 8.166509
56B:B:D83 5.5075448
57B:B:Y85 8.136544
58B:B:K89 8.995409
59B:B:I93 5.4054117
60B:B:W99 5.1925869
61B:B:V100 6.59754119
62B:B:Y105 4.9725406
63B:B:N110 6.544174
64B:B:C114 2.724118
65B:B:G115 1.93254119
66B:B:L117 3.725469
67B:B:D118 5.0354259
68B:B:Y124 4.168336116
69B:B:E130 6.8425403
70B:B:V133 5.374114
71B:B:H142 5.476129
72B:B:Y145 3.225668
73B:B:F151 4.5125179
74B:B:L152 4.605423
75B:B:D154 4.7254176
76B:B:Q156 4.52405
77B:B:V158 4.99425
78B:B:D163 6.7654129
79B:B:W169 7.481676128
80B:B:F180 6.98667627
81B:B:H183 4.39429729
82B:B:D186 5.115469
83B:B:L190 5.045425
84B:B:F199 5.138529
85B:B:S201 4.5725429
86B:B:K209 8.705426
87B:B:L210 4.4725405
88B:B:W211 9.75628
89B:B:E215 5.8725423
90B:B:F222 5.954578
91B:B:H225 8.668579
92B:B:D228 9.685409
93B:B:I232 5.3375478
94B:B:F234 4.75205
95B:B:F235 6.17167606
96B:B:F241 6.372576
97B:B:T243 4.13478
98B:B:D247 4.6409
99B:B:T249 3.1476
100B:B:R251 8.955478
101B:B:F253 6.464576
102B:B:D258 11.2225477
103B:B:L261 2.8075405
104B:B:M262 5.954104
105B:B:Y264 4.406676105
106B:B:H266 3.97404
107B:B:F278 5.6125407
108B:B:L285 3.64754106
109B:B:Y289 5.8825107
110B:B:D290 6.784146
111B:B:N295 5.6954106
112B:B:W297 4.9985108
113B:B:L308 4.23754167
114B:B:H311 9.7154219
115B:B:R314 10.0454148
116B:B:V315 4.50754217
117B:B:T321 4.4725447
118B:B:M325 6.322545
119B:B:S331 8.24219
120B:B:W332 10.3556149
121B:B:D333 6.54219
122B:B:K337 5.38254166
123B:B:W339 7.0585169
124G:G:I9 2.5125402
125G:G:L19 5.23409
126G:G:D48 4.382509
127G:G:L51 3.595406
128G:G:N59 6.41549
129G:G:F61 6.055648
130R:R:F533 4.60429719
131R:R:L536 6.45519
132R:R:M537 5.255419
133R:R:L547 3.6565229
134R:R:L555 5.794519
135R:R:L559 7.0225418
136R:R:F569 4.555459
137R:R:V572 4.4325239
138R:R:H583 9.265459
139R:R:L584 3.35459
140R:R:H585 4.886559
141R:R:I588 3.68457
142R:R:L590 3.4725409
143R:R:F591 6.5125419
144R:R:F597 7.814519
145R:R:V608 2.6525406
146R:R:H620 6.01833619
147R:R:C622 3.34307
148R:R:W629 5.395859
149R:R:E633 5.6275459
150R:R:L637 2.16409
151R:R:V642 4.7125409
152R:R:V644 4.5575499
153R:R:W654 4.69754316
154R:R:L655 2.75457
155R:R:Y660 3.5725459
156R:R:P663 3.2675409
157R:R:R680 5.434518
158R:R:Y683 3.846516
159R:R:W685 7.01667619
160R:R:D687 6.584515
161R:R:F696 6.486519
162R:R:L697 3.2775407
163R:R:F722 4.9154188
164R:R:Q745 4.1375409
165R:R:F747 9.566505
166R:R:L748 7.354558
167R:R:L749 3.85509
168R:R:T752 5.765419
169R:R:W753 7.55667619
170R:R:F755 3.275408
171R:R:Y769 4.9685229
172R:R:F771 6.57333619
173R:R:L782 5.345458
174R:R:Y783 5.768559
175R:R:H786 13.016559
176R:R:C787 5.4625459
177R:R:Y797 3.8875409
178R:R:W800 5.344236
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L95 B:B:Y124 15.82343.52NoYes1186
2B:B:L95 B:B:V100 16.83164.47NoYes1189
3B:B:V100 B:B:Y59 19.097416.4YesYes098
4B:B:Q75 B:B:Y59 20.29262.25NoYes098
5B:B:K57 B:B:Q75 33.29059.49YesNo099
6B:B:K57 B:B:W332 31.553622.05YesYes1499
7B:B:S316 B:B:W332 28.79473.71NoYes099
8B:B:C317 B:B:S316 28.62463.44NoNo079
9B:B:C317 B:B:M61 19.15233.24NoYes076
10B:B:Q75 B:B:W99 41.41752.19NoYes099
11A:A:F238 B:B:W99 58.26065.01YesYes699
12A:A:F238 A:A:L44 59.943113.4YesNo099
13A:A:L44 A:A:L46 59.95564.15NoYes098
14A:A:G47 A:A:L46 1001.71NoYes098
15A:A:G47 A:A:S51 99.09683.71NoYes2499
16A:A:G52 A:A:S51 99.55113.71NoYes099
17A:A:G52 A:A:T55 99.49331.82NoYes099
18A:A:Q59 A:A:T55 99.31734.25NoYes099
19A:A:I56 A:A:Q59 88.62112.74NoNo079
20A:A:I56 A:A:M60 88.46064.37NoNo079
21A:A:M221 A:A:M60 88.38737.22NoNo089
22A:A:F212 A:A:M221 88.3178.71YesNo098
23A:A:F212 A:A:F219 88.097811.79YesYes098
24A:A:F219 A:A:H41 87.40643.39YesYes986
25A:A:H41 A:A:I383 87.37892.65YesYes968
26A:A:L46 A:A:R231 43.7477.29YesNo089
27A:A:D272 A:A:R231 25.47343.57NoNo089
28A:A:D272 A:A:F246 25.27472.39NoNo089
29A:A:F246 A:A:L289 22.85593.65NoYes399
30A:A:F345 A:A:L289 15.71313.65YesYes389
31A:A:N371 A:A:Q59 10.69462.64YesNo099
32B:B:L117 B:B:W99 28.84934.56YesYes699
33A:A:Q227 A:A:V224 29.28412.87YesNo099
34A:A:V224 A:A:W234 29.295215.94NoNo099
35B:B:L117 B:B:Y145 27.69323.52YesYes698
36A:A:K233 B:B:Y145 41.12342.39YesYes698
37A:A:K233 B:B:D228 40.14149.68YesYes099
38A:A:W281 B:B:D290 12.01836.7YesYes1456
39A:A:H387 A:A:I383 88.71972.65NoYes988
40A:A:H387 R:R:L640 91.33157.71NoNo086
41R:R:E636 R:R:L640 90.8785.3NoNo076
42B:B:C317 B:B:G330 16.46121.96NoNo075
43B:B:G330 B:B:S331 16.31923.71NoYes059
44B:B:G244 B:B:S245 19.91251.86NoNo059
45B:B:H225 B:B:S245 13.349915.34YesNo099
46B:B:H225 B:B:T243 15.60875.48YesYes798
47B:B:D258 B:B:F222 13.97765.97YesYes778
48B:B:D258 B:B:R22 12.592413.1YesYes776
49B:B:I18 B:B:R22 11.16186.26NoYes076
50B:B:F222 B:B:F253 15.00244.29YesYes786
51B:B:F253 B:B:R251 15.20873.21YesYes768
52B:B:M45 G:G:L50 10.0582.83NoNo049
53B:B:V112 B:B:Y124 12.68533.79NoYes086
54B:B:V112 B:B:Y105 12.43582.52NoYes086
55B:B:H62 B:B:Y105 11.71266.53NoYes066
56B:B:A104 B:B:H62 11.46092.93NoNo076
57B:B:A104 B:B:R150 11.20882.77NoNo076
58B:B:G162 B:B:Y145 18.79252.9NoYes098
59B:B:G162 B:B:S161 18.4413.71NoNo099
60B:B:H142 B:B:S161 15.918415.34YesNo1299
61B:B:H142 B:B:W169 12.3395.29YesYes1298
62B:B:L139 B:B:W169 10.58217.08NoYes098
63B:B:L192 B:B:R150 10.95632.43NoNo056
64B:B:D247 B:B:S245 18.42585.89YesNo099
65B:B:D247 B:B:T249 20.1882.89YesYes096
66B:B:D228 B:B:S227 39.04585.89YesNo096
67B:B:C250 B:B:Y264 10.93024.03NoYes085
68B:B:D290 B:B:G272 12.47445.03YesNo064
69B:B:A248 B:B:G272 12.23181.95NoNo054
70B:B:A248 B:B:I269 11.99943.25NoNo054
71B:B:I269 B:B:Y289 11.14942.42NoYes047
72R:R:E636 R:R:S578 90.88774.31NoNo078
73R:R:L655 R:R:S578 90.79633YesNo078
74R:R:L655 R:R:W629 72.35342.28YesYes579
75R:R:L586 R:R:W629 51.47026.83NoYes099
76R:R:L586 R:R:L590 35.49674.15NoYes099
77R:R:F623 R:R:L590 34.96752.44NoYes089
78R:R:F623 R:R:L536 18.38453.65NoYes189
79R:R:L536 R:R:W685 10.71889.11YesYes199
80R:R:F623 R:R:F696 16.42268.57NoYes189
81R:R:F696 R:R:W685 10.44788.02YesYes199
82R:R:L586 R:R:M630 16.12114.24NoNo099
83R:R:F627 R:R:M630 15.73023.73NoNo099
84R:R:F627 R:R:W753 13.980517.04NoYes099
85R:R:G756 R:R:I759 13.05791.76NoNo098
86R:R:I759 R:R:T768 11.50374.56NoNo087
87R:R:I582 R:R:W629 10.5822.35NoYes589
88R:R:E633 R:R:I582 19.56325.47YesNo598
89R:R:H585 R:R:L584 15.65062.57YesYes599
90R:R:F569 R:R:L584 14.89432.44YesYes599
91R:R:C787 R:R:F569 14.31495.59YesYes599
92R:R:C787 R:R:Y783 15.36946.72YesYes599
93R:R:T568 R:R:Y783 14.67592.5NoYes099
94R:R:T568 R:R:Y797 14.19237.49NoYes099
95R:R:H620 R:R:W685 10.16532.12YesYes199
96R:R:G617 R:R:H620 10.61691.59NoYes089
97R:R:E633 R:R:L749 14.04795.3YesYes099
98A:A:I276 A:A:L46 10.1752.85NoYes088
99B:B:D247 B:B:S227 38.79724.42YesNo096
100B:B:R251 B:B:T249 13.69575.17YesYes786
101B:B:C250 B:B:G244 14.94761.96NoNo085
102A:A:R231 A:A:W234 29.32914NoNo099
103A:A:Q227 B:B:Y145 28.21382.25YesYes698
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7YDP
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRE5
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.1
Date 2023-07-12
D.O.I. 10.1016/j.chembiol.2023.08.003
Net Summary
Imin 1.84
Number of Linked Nodes 840
Number of Links 1042
Number of Hubs 178
Number of Links mediated by Hubs 636
Number of Communities 32
Number of Nodes involved in Communities 260
Number of Links involved in Communities 370
Path Summary
Number Of Nodes in MetaPath 104
Number Of Links MetaPath 103
Number of Shortest Paths 872574
Length Of Smallest Path 3
Average Path Length 29.4069
Length of Longest Path 59
Minimum Path Strength 1.33
Average Path Strength 5.18071
Maximum Path Strength 19.54
Minimum Path Correlation 0.7
Average Path Correlation 0.979984
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 45.7325
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.2543
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• response to stimulus   • immune response   • immune system process   • regulation of biological process   • signaling   • biological regulation   • cell-cell signaling   • cellular process   • cell communication   • cellular response to stimulus   • regulation of cellular process   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • cell surface receptor signaling pathway   • cell adhesion   • defense response   • response to stress   • inflammatory response   • cellular anatomical structure   • anchoring junction   • cell junction   • focal adhesion   • cell-substrate junction   • membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle
Gene OntologyCellular Component• cellular anatomical structure   • anchoring junction   • cell junction   • focal adhesion   • cell-substrate junction   • membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • cell periphery   • plasma membrane   • intracellular anatomical structure   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle membrane   • bounding membrane of organelle   • vesicle membrane   • cytoplasmic vesicle   • secretory granule   • secretory vesicle   • cytoplasm   • organelle membrane   • secretory granule membrane   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • synapse   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • D1 dopamine receptor binding   • molecular function activator activity   • enzyme activator activity   • cyclase activator activity   • adenylate cyclase activator activity   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • establishment of protein localization   • nitrogen compound transport   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • regulation of hormone secretion   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • lysosomal membrane   • lysosome   • Golgi apparatus   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • Golgi apparatus subcompartment   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7YDP_Chain_A
LSAEDKAAV ERSKMIEKQ LQKDKQVYR ATHRLLLLG ADNSGKSTI 
VKQMRIYHT SGIFETKFQ VDKVNFHMF DVGAQRDER RKWIQCFND 
VTAIIFVVD SSDYNRLQE ALNDFKSIW NNRWLRTIS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRDEFLRIS TASGDGRHY CYPHFTCSV DTENARRIF NDCRDIIQR 
MHLRQYE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7YDP_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7YDP_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP48960
Sequence
>7YDP_Chain_R
SSFAILMAH YDVEDWKLT LITRVGLAL SLFCLLLCI LTFLLVRPI 
QGSRTTIHL HLCICLFVG STIFLAGIE NEGGQVGLR CRLVAGLLH 
YCFLAAFCW MSLEGLELY FLVVRVFST RWLCLIGYG VPLLIVGVS 
AAIYSKGYG RPRYCWLDF EQGFLWSFL GPVTFIILC NAVIFVTTV 
WKLTQKFSE INPDMKKLK KARALTITA IAQLFLLGC TWVFGLFIF 
DDRSLVLTY VFTILNCLQ GAFLYLLHC LLNKKVREE YRKWACLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IKJB2AdhesionAdhesionADGRE5Homo sapiens---3.22024-02-1410.1016/j.molcel.2023.12.020
8IKLB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1L-G13)/β1/γ22.332024-01-2410.1016/j.molcel.2023.12.020
8IKL (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--2.332024-01-2410.1016/j.molcel.2023.12.020
7YDJB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-G12)/β1/γ23.032023-07-12To be published
7YDJ (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--3.032023-07-12To be published
7YDMB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.892023-07-1210.1016/j.chembiol.2023.08.003
7YDM (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--2.892023-07-1210.1016/j.chembiol.2023.08.003
7YDPB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs)/β1/γ23.12023-07-1210.1016/j.chembiol.2023.08.003
7YDP (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--3.12023-07-1210.1016/j.chembiol.2023.08.003
7YDHB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi2-G13)/β1/γ23.12023-07-1210.1016/j.chembiol.2023.08.003
7YDH (No Gprot) B2AdhesionAdhesionADGRE5Homo sapiens--3.12023-07-1210.1016/j.chembiol.2023.08.003




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