Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F533 4.60429719
2R:R:L536 6.45519
3R:R:M537 5.255419
4R:R:D544 5.914158
5R:R:K546 10.91754154
6R:R:L547 3.6565159
7R:R:L555 5.1175419
8R:R:L559 7.02254238
9R:R:F569 4.555459
10R:R:V572 4.624249
11R:R:H583 9.265459
12R:R:L584 3.35459
13R:R:H585 4.886559
14R:R:I588 3.68457
15R:R:L590 3.4725409
16R:R:F591 6.51254239
17R:R:F597 7.814519
18R:R:V608 2.6525406
19R:R:H620 6.01833619
20R:R:C622 3.34257
21R:R:W629 5.395859
22R:R:E633 5.6275459
23R:R:L637 2.16409
24R:R:V642 4.7125409
25R:R:V644 4.5575499
26R:R:W654 4.69754266
27R:R:L655 2.75457
28R:R:Y660 3.5725459
29R:R:P663 3.2675409
30R:R:R680 5.434518
31R:R:Y683 3.846516
32R:R:W685 7.01667619
33R:R:D687 6.584515
34R:R:F696 6.486519
35R:R:L697 3.2775407
36R:R:F722 4.9154198
37R:R:Q745 4.1375409
38R:R:F747 9.566505
39R:R:L748 7.354558
40R:R:L749 3.85509
41R:R:T752 5.765419
42R:R:W753 7.55667619
43R:R:F755 3.275408
44R:R:Y769 5.4445159
45R:R:F771 6.57333619
46R:R:L782 5.345458
47R:R:Y783 5.768559
48R:R:H786 11.06659
49R:R:C787 5.4625459
50G:G:I9 2.5125402
51G:G:L19 5.23409
52G:G:D48 4.382509
53G:G:L51 3.595406
54G:G:N59 6.41549
55G:G:F61 6.055648
56A:A:Y37 5.06254134
57A:A:H41 3.5725496
58A:A:L46 4408
59A:A:S51 3.85754299
60A:A:K53 4.46754299
61A:A:T55 3.1175409
62A:A:F212 6.5525409
63A:A:V214 4.40754206
64A:A:F219 5.3875498
65A:A:Q227 2.808569
66A:A:K233 4.95569
67A:A:F238 6.805469
68A:A:N239 4.65754148
69A:A:Y253 7.7385178
70A:A:L270 3.8675406
71A:A:F273 5.7075439
72A:A:W277 5.55857736
73A:A:W281 5.306676145
74A:A:I288 5.63667689
75A:A:L289 4.75439
76A:A:F290 4.48333689
77A:A:L291 3.09438
78A:A:L296 5.28406
79A:A:I308 4.54254177
80A:A:Y311 6.16254176
81A:A:F312 3.04254178
82A:A:Y318 6.495406
83A:A:P321 4.05333635
84A:A:E330 7.4575433
85A:A:D331 7.29404
86A:A:T335 5.0675434
87A:A:Y339 6.696533
88A:A:R342 5.24534
89A:A:F345 4.23538
90A:A:L346 4.2025434
91A:A:C359 3.576535
92A:A:Y360 8.2775408
93A:A:F363 6.13435
94A:A:T364 6.6225489
95A:A:D368 7.4489
96A:A:N371 7.312589
97A:A:R374 8.138584
98A:A:F376 8.7754208
99A:A:I383 3.035498
100B:B:R22 6.2875476
101B:B:L51 4.8375409
102B:B:H54 6.376676139
103B:B:K57 10.66254149
104B:B:Y59 7.665408
105B:B:M61 3.022546
106B:B:W63 4.85833647
107B:B:R68 10.645445
108B:B:D76 4.088336139
109B:B:K78 5.5154138
110B:B:W82 8.166509
111B:B:D83 5.5075448
112B:B:Y85 8.136544
113B:B:K89 8.995409
114B:B:I93 5.4054117
115B:B:W99 5.1925869
116B:B:V100 6.59754119
117B:B:Y105 4.9725406
118B:B:N110 6.544184
119B:B:C114 2.724118
120B:B:G115 1.93254119
121B:B:L117 3.725469
122B:B:D118 5.0354309
123B:B:Y124 4.168336116
124B:B:E130 6.8425403
125B:B:V133 5.374114
126B:B:H142 5.476129
127B:B:Y145 3.225668
128B:B:F151 4.5125189
129B:B:L152 4.605423
130B:B:D154 4.7254186
131B:B:Q156 4.52405
132B:B:V158 4.99425
133B:B:D163 6.7654129
134B:B:W169 7.481676128
135B:B:F180 6.98667627
136B:B:H183 4.39429729
137B:B:D186 5.115469
138B:B:L190 5.045425
139B:B:F199 5.138529
140B:B:S201 4.5725429
141B:B:K209 8.705426
142B:B:L210 4.4725405
143B:B:W211 9.75628
144B:B:E215 5.8725423
145B:B:F222 5.954578
146B:B:H225 8.668579
147B:B:D228 9.685409
148B:B:I232 5.3375478
149B:B:F234 4.75215
150B:B:F235 6.17167606
151B:B:F241 6.372576
152B:B:T243 3.668578
153B:B:G244 2.2925405
154B:B:D247 4.6409
155B:B:T249 3.1476
156B:B:R251 8.955478
157B:B:F253 6.464576
158B:B:D258 11.2225477
159B:B:L261 2.8075405
160B:B:M262 5.954104
161B:B:Y264 4.406676105
162B:B:H266 3.97404
163B:B:F278 5.6125407
164B:B:L285 3.64754106
165B:B:Y289 5.8825107
166B:B:D290 6.784146
167B:B:N295 5.6954106
168B:B:W297 4.9985108
169B:B:L308 4.23754167
170B:B:H311 9.7154229
171B:B:R314 10.0454148
172B:B:V315 4.50754227
173B:B:T321 3.942547
174B:B:M325 6.322545
175B:B:S331 8.24229
176B:B:W332 10.3556149
177B:B:D333 6.54229
178B:B:K337 5.38254166
179B:B:W339 7.0585169
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:G756 R:R:I759 14.66331.76NoNo098
2R:R:I759 R:R:T768 13.16074.56NoNo087
3R:R:L547 R:R:T768 10.63534.42YesNo097
4R:R:L536 R:R:W685 10.61519.11YesYes199
5R:R:F623 R:R:L536 17.62113.65NoYes189
6R:R:F623 R:R:L590 34.03882.44NoYes089
7R:R:L586 R:R:W629 51.74756.83NoYes099
8R:R:L586 R:R:L590 34.43454.15NoYes099
9R:R:I575 R:R:K792 10.32474.36NoNo099
10R:R:E636 R:R:S578 78.12014.31NoNo078
11R:R:L655 R:R:S578 78.0213YesNo078
12R:R:L655 R:R:W629 66.0572.28YesYes579
13R:R:E636 R:R:L640 78.23695.3NoNo076
14R:R:I582 R:R:W629 10.85262.35NoYes589
15R:R:E633 R:R:I582 20.16365.47YesNo598
16R:R:F627 R:R:W753 15.293717.04NoYes099
17R:R:F627 R:R:M630 17.02653.73NoNo099
18R:R:G617 R:R:H620 10.52731.59NoYes089
19R:R:H620 R:R:W685 10.0632.12YesYes199
20R:R:E633 R:R:L749 13.8735.3YesYes099
21A:A:H387 R:R:L640 78.62697.71NoNo086
22A:A:H387 A:A:I383 76.73872.65NoYes988
23B:B:D258 B:B:R22 11.089713.1YesYes776
24B:B:D258 B:B:F222 12.30545.97YesYes778
25B:B:F222 B:B:F253 12.69144.29YesYes786
26B:B:F253 B:B:R251 12.39373.21YesYes768
27B:B:R251 B:B:T249 12.74885.17YesYes786
28B:B:D247 B:B:T249 18.83852.89YesYes096
29B:B:D247 B:B:S227 34.02544.42YesNo096
30B:B:D228 B:B:S227 34.25345.89YesNo096
31A:A:K233 B:B:D228 35.25389.68YesYes099
32A:A:K233 B:B:Y145 36.18122.39YesYes698
33A:A:Q227 B:B:Y145 25.5572.25YesYes698
34A:A:Q227 A:A:V224 26.68832.87YesNo099
35A:A:V224 A:A:W234 26.710915.94NoNo099
36A:A:R231 A:A:W234 26.7674NoNo099
37A:A:L46 A:A:R231 41.4147.29YesNo089
38A:A:G47 A:A:L46 1001.71NoYes098
39A:A:G47 A:A:S51 99.07873.71NoYes2999
40A:A:G52 A:A:S51 99.47583.71NoYes099
41A:A:G52 A:A:T55 99.40871.82NoYes099
42A:A:Q59 A:A:T55 99.20494.25NoYes099
43A:A:I56 A:A:Q59 77.32342.74NoNo079
44A:A:I56 A:A:M60 77.10574.37NoNo079
45A:A:M221 A:A:M60 77.00757.22NoNo089
46A:A:F212 A:A:M221 76.91678.71YesNo098
47A:A:F212 A:A:F219 76.534611.79YesYes098
48A:A:F219 A:A:H41 75.81993.39YesYes986
49A:A:H41 A:A:I383 75.74562.65YesYes968
50B:B:L117 B:B:Y145 25.48933.52YesYes698
51B:B:L117 B:B:W99 26.56924.56YesYes699
52A:A:F238 B:B:W99 58.91535.01YesYes699
53A:A:F238 A:A:L44 60.500613.4YesNo099
54A:A:L44 A:A:L46 60.5264.15NoYes098
55B:B:A104 B:B:R150 10.04582.77NoNo076
56B:B:A104 B:B:H62 10.26582.93NoNo076
57B:B:H62 B:B:Y105 10.48556.53NoYes066
58B:B:V112 B:B:Y105 11.11392.52NoYes086
59B:B:V112 B:B:Y124 11.33163.79NoYes086
60B:B:L95 B:B:Y124 14.063.52NoYes1186
61B:B:L95 B:B:V100 14.94064.47NoYes1189
62B:B:V100 B:B:Y59 16.919516.4YesYes098
63B:B:Q75 B:B:Y59 17.95832.25NoYes098
64B:B:Q75 B:B:W99 44.72162.19NoYes099
65B:B:F235 B:B:F278 10.71516.43YesYes067
66B:B:A287 B:B:W297 14.37022.59NoYes1068
67B:B:A287 B:B:G288 19.14691.95NoNo067
68B:B:G288 B:B:T274 23.96191.82NoNo078
69B:B:R314 B:B:T274 24.49056.47YesNo088
70A:A:W281 B:B:R314 11.13936YesYes1458
71A:A:N279 A:A:W281 13.78123.39NoYes085
72A:A:L282 A:A:N279 13.696112.36NoNo098
73A:A:I285 A:A:L282 13.65842.85NoNo079
74A:A:I244 A:A:I285 13.69971.47NoNo087
75A:A:I244 A:A:I276 13.79431.47NoNo088
76A:A:I276 A:A:L46 13.95142.85NoYes088
77B:B:R314 B:B:W332 13.987916.99YesYes1489
78B:B:K57 B:B:W332 34.658622.05YesYes1499
79B:B:K57 B:B:Q75 35.31559.49YesNo099
80B:B:T321 B:B:W63 12.54957.28YesYes477
81B:B:M61 B:B:W63 12.34312.33YesYes467
82B:B:C317 B:B:M61 20.33623.24NoYes076
83B:B:C317 B:B:S316 20.78693.44NoNo079
84B:B:S316 B:B:W332 20.96293.71NoYes099
85B:B:G288 B:B:V315 11.09763.68NoYes077
86A:A:F345 A:A:L289 15.72763.65YesYes389
87A:A:F246 A:A:L289 22.89263.65NoYes399
88A:A:D272 A:A:F246 25.31662.39NoNo089
89A:A:D272 A:A:R231 25.5173.57NoNo089
90A:A:D378 A:A:Y360 18.218522.99NoYes078
91A:A:S286 A:A:Y360 12.62462.54NoYes088
92A:A:I382 A:A:S286 12.26569.29NoNo068
93A:A:I382 A:A:M386 12.01341.46NoNo063
94A:A:M386 A:A:Q390 11.77231.36NoNo034
95A:A:Q390 R:R:K792 11.53151.36NoNo049
96B:B:H142 B:B:W169 11.37445.29YesYes1298
97B:B:H142 B:B:S161 14.67315.34YesNo1299
98B:B:G162 B:B:S161 16.9983.71NoNo099
99B:B:G162 B:B:Y145 17.32182.9NoYes098
100B:B:I232 B:B:T243 10.854.56YesYes788
101B:B:H225 B:B:T243 10.24035.48YesYes798
102B:B:D247 B:B:S245 15.11855.89YesNo099
103B:B:G244 B:B:T243 11.86131.82YesYes058
104R:R:F696 R:R:W685 10.35798.02YesYes199
105R:R:F623 R:R:F696 16.25758.57NoYes189
106R:R:L586 R:R:M630 17.41344.24NoNo099
107A:A:N371 A:A:Q59 21.94012.64YesNo099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7YDP
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRE5
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.1
Date 2023-07-12
D.O.I. 10.1016/j.chembiol.2023.08.003
Net Summary
Imin 1.82
Number of Linked Nodes 843
Number of Links 1049
Number of Hubs 179
Number of Links mediated by Hubs 638
Number of Communities 34
Number of Nodes involved in Communities 262
Number of Links involved in Communities 371
Path Summary
Number Of Nodes in MetaPath 108
Number Of Links MetaPath 107
Number of Shortest Paths 896382
Length Of Smallest Path 3
Average Path Length 28.8794
Length of Longest Path 59
Minimum Path Strength 1.33
Average Path Strength 5.20477
Maximum Path Strength 19.54
Minimum Path Correlation 0.7
Average Path Correlation 0.979305
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 44.4987
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.0512
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP48960
Sequence
>7YDP_Chain_R
SSFAILMAH YDVEDWKLT LITRVGLAL SLFCLLLCI LTFLLVRPI 
QGSRTTIHL HLCICLFVG STIFLAGIE NEGGQVGLR CRLVAGLLH 
YCFLAAFCW MSLEGLELY FLVVRVFST RWLCLIGYG VPLLIVGVS 
AAIYSKGYG RPRYCWLDF EQGFLWSFL GPVTFIILC NAVIFVTTV 
WKLTQKFSE INPDMKKLK KARALTITA IAQLFLLGC TWVFGLFIF 
DDRSLVLTY VFTILNCLQ GAFLYLLHC LLNKKVREE YRKWACLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7YDP_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7YDP_Chain_A
LSAEDKAAV ERSKMIEKQ LQKDKQVYR ATHRLLLLG ADNSGKSTI 
VKQMRIYHT SGIFETKFQ VDKVNFHMF DVGAQRDER RKWIQCFND 
VTAIIFVVD SSDYNRLQE ALNDFKSIW NNRWLRTIS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRDEFLRIS TASGDGRHY CYPHFTCSV DTENARRIF NDCRDIIQR 
MHLRQYE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7YDP_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YDHB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi2-G13)/&β;1/&γ;23.12023-07-1210.1016/j.chembiol.2023.08.003
7YDJB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-G12)/&β;1/&γ;23.032023-07-12To be published
7YDMB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.892023-07-1210.1016/j.chembiol.2023.08.003
7YDPB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;23.12023-07-1210.1016/j.chembiol.2023.08.003
8IKJB2AdhesionAdhesionADGRE5Homo sapiens---3.22024-02-1410.1016/j.molcel.2023.12.020
8IKLB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1L-G13)/&β;1/&γ;22.332024-01-2410.1016/j.molcel.2023.12.020




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7YDP.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.