Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:D33 2.785404
2A:A:L62 5.53429
3A:A:E213 6.085479
4A:A:H214 4.4125427
5A:A:F216 4.235139
6A:A:I218 5.195135
7A:A:F223 5.9225137
8A:A:K224 5.89407
9A:A:M225 3.9675407
10A:A:D227 6.278529
11A:A:W238 4.41667679
12A:A:F242 3.5225479
13A:A:I248 4.0675448
14A:A:L249 3.2725428
15A:A:V252 3.41407
16A:A:F277 5.786549
17A:A:F286 3.785449
18A:A:F294 3.27667629
19A:A:L301 4.38254109
20A:A:D320 5.2954103
21A:A:L324 6.066103
22A:A:L346 5.055446
23A:A:H349 6.7525429
24A:A:D355 7.9975429
25A:A:F363 5.61754138
26A:A:I370 3.535408
27A:A:Q372 4.384145
28A:A:L375 3.1554148
29A:A:L380 6.91254148
30B:B:D27 4.745408
31B:B:V40 4.6565173
32B:B:H54 7.1675409
33B:B:L55 4.584506
34B:B:W63 7.378507
35B:B:W82 8.7375409
36B:B:S84 3.965495
37B:B:Y85 11.0475494
38B:B:K89 7.3425409
39B:B:H91 4.2165195
40B:B:L95 4.4954248
41B:B:W99 5.78667679
42B:B:Y105 3506
43B:B:Y111 4.95404
44B:B:I123 3.528516
45B:B:Y124 3.72506
46B:B:T128 3.274253
47B:B:H142 6.89333619
48B:B:Y145 3.9625478
49B:B:C149 2.63418
50B:B:R150 3.41486
51B:B:T159 4.64419
52B:B:D163 8.4325419
53B:B:W169 7.602518
54B:B:F180 7.0175487
55B:B:H183 5.5225269
56B:B:L190 3.555485
57B:B:F199 4.6875489
58B:B:W211 6.538588
59B:B:D212 4.7425439
60B:B:Q220 3.872537
61B:B:F222 3.654538
62B:B:H225 7.53539
63B:B:D228 3.9645219
64B:B:F235 6.362867186
65B:B:F241 4.68167636
66B:B:T243 4.79438
67B:B:R251 5.985408
68B:B:F253 3.788536
69B:B:D254 2.8175409
70B:B:L255 2.88436
71B:B:D258 7.89437
72B:B:Y264 4.14167605
73B:B:C271 6.655455
74B:B:F278 5.2475407
75B:B:R283 7.32754179
76B:B:Y289 5.46167657
77B:B:D290 8.27456
78B:B:N295 5.81456
79B:B:V296 3.9405
80B:B:W297 4.1475458
81B:B:K301 5.015405
82B:B:L308 3.5854157
83B:B:H311 8.4554279
84B:B:T321 6.19254237
85B:B:W332 15.755459
86B:B:D333 7.09754279
87B:B:W339 4.4985159
88G:G:L19 2.4575409
89G:G:E22 5.045489
90G:G:D48 5.85509
91G:G:L51 3.044176
92G:G:N59 7.6875499
93G:G:F61 4.53143798
94R:R:S531 4.79254169
95R:R:F533 4.2156119
96R:R:L555 3.3445119
97R:R:L562 3.81409
98R:R:F569 3.754509
99R:R:I575 3.79409
100R:R:R579 3.302569
101R:R:H583 6.312569
102R:R:L584 3.3409
103R:R:H585 6.198569
104R:R:F591 6.174309
105R:R:H620 3.626129
106R:R:Y621 2.7875406
107R:R:L624 5.1575409
108R:R:W629 6.50714769
109R:R:E633 8.345469
110R:R:V641 1.5225409
111R:R:F645 5.405409
112R:R:Y660 3.255469
113R:R:P663 3.92667609
114R:R:Y674 7.1425405
115R:R:Y678 4.123336129
116R:R:R680 6.4508
117R:R:Y683 4.381676166
118R:R:W685 5.1956129
119R:R:F692 4.655408
120R:R:F696 2.5254129
121R:R:F711 2.5425408
122R:R:L718 5.55754148
123R:R:K721 2.764149
124R:R:F722 6.505408
125R:R:M729 4.42407
126R:R:F747 6.6475405
127R:R:L748 6.215468
128R:R:W753 7.4156119
129R:R:F755 3.28408
130R:R:F771 5.625409
131R:R:N775 8.35754119
132R:R:C776 3.22754118
133R:R:Y783 5.4954319
134R:R:L785 2.1408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:N88 B:B:T86 11.55810.24NoNo076
2B:B:D83 B:B:T86 11.79694.34NoNo086
3B:B:D83 B:B:L69 39.40824.07NoNo085
4B:B:L69 B:B:Y105 39.61762.34NoYes056
5B:B:V112 B:B:Y105 85.10942.52NoYes086
6B:B:V112 B:B:Y124 85.2653.79NoYes086
7B:B:L95 B:B:Y124 88.02813.52YesYes086
8B:B:G77 B:B:L95 89.38225.13NoYes088
9B:B:G77 B:B:S98 89.53151.86NoNo088
10A:A:E213 B:B:S98 83.89472.87YesNo798
11A:A:E213 A:A:K224 92.97166.75YesYes097
12A:A:K224 A:A:L57 93.34025.64YesNo076
13A:A:L57 A:A:P222 93.46423.28NoNo064
14A:A:I221 A:A:P222 94.55393.39NoNo044
15A:A:F223 A:A:I221 96.05782.51YesNo074
16A:A:F223 A:A:I60 48.04642.51YesNo077
17A:A:I60 A:A:M225 48.08472.92NoYes077
18A:A:F216 A:A:F223 48.23475.36YesYes1397
19A:A:F216 A:A:M225 50.06434.98YesYes097
20A:A:L62 A:A:M225 49.69814.24YesYes097
21A:A:L249 A:A:L62 48.50674.15YesYes289
22A:A:F73 A:A:M225 48.45223.73NoYes077
23A:A:F73 A:A:L249 47.70732.44NoYes078
24A:A:F294 A:A:T351 10.99913.89YesNo099
25A:A:N296 A:A:T351 10.68677.31NoNo099
26B:B:L284 B:B:V296 11.06062.98NoYes055
27B:B:L284 B:B:S279 11.14973NoNo059
28B:B:S279 G:G:D48 11.36845.89NoYes099
29G:G:D48 G:G:P49 19.46114.83YesNo097
30B:B:G324 G:G:P49 19.6744.06NoNo097
31B:B:G324 B:B:T321 19.89321.82NoYes097
32B:B:T321 B:B:W63 20.64210.92YesYes077
33B:B:S84 B:B:W63 22.65024.94YesYes057
34B:B:S84 B:B:Y85 20.92352.54YesYes954
35B:B:R68 B:B:Y85 27.274425.72NoYes054
36B:B:D83 B:B:R68 27.696314.29NoNo085
37A:A:I292 A:A:L249 91.4932.85NoYes298
38A:A:A365 A:A:I292 95.6223.25NoNo079
39A:A:A365 A:A:F347 95.40648.32NoNo079
40A:A:F347 A:A:P345 1005.78NoNo094
41A:A:P345 A:A:Q372 99.54263.16NoYes045
42A:A:Q372 R:R:K721 98.58412.71YesYes1459
43A:A:L375 R:R:K721 97.93482.82YesYes1489
44A:A:L375 R:R:V641 94.21811.49YesYes089
45R:R:T714 R:R:V641 91.86581.59NoYes099
46R:R:L637 R:R:T714 91.62932.95NoNo099
47R:R:L637 R:R:Q745 89.72932.66NoNo099
48R:R:Q745 R:R:R579 88.05472.34NoYes099
49R:R:H583 R:R:R579 15.48342.26YesYes699
50R:R:F569 R:R:H583 14.17175.66YesYes099
51B:B:H62 B:B:Y105 50.81353.27NoYes066
52B:B:H62 B:B:R150 40.25653.39NoYes066
53B:B:L190 B:B:R150 39.20712.43YesYes856
54B:B:L190 B:B:S160 31.81443YesNo056
55B:B:S160 B:B:V187 31.60634.85NoNo069
56B:B:A203 B:B:V187 30.49345.09NoNo2689
57B:B:A203 B:B:G202 31.2721.95NoNo086
58B:B:A208 B:B:G202 29.01241.95NoNo066
59B:B:A208 B:B:F241 28.80592.77NoYes066
60B:B:F241 B:B:F253 20.5968.57YesYes366
61B:B:F253 B:B:T243 18.46352.59YesYes368
62B:B:G244 B:B:T243 17.30173.64NoYes058
63B:B:A104 B:B:H62 12.4812.93NoNo076
64B:B:A104 B:B:A113 12.24191.79NoNo079
65B:B:A113 B:B:C149 12.00261.81NoYes098
66B:B:C149 B:B:T159 11.0331.69YesYes189
67R:R:E633 R:R:R579 71.60952.33YesYes699
68R:R:E633 R:R:I582 70.71519.56YesNo698
69R:R:I582 R:R:W629 68.78648.22NoYes689
70R:R:L586 R:R:W629 36.9592.28NoYes099
71R:R:L586 R:R:M630 36.41842.83NoNo099
72R:R:F627 R:R:M630 35.89173.73NoNo099
73R:R:F627 R:R:W753 28.452312.03NoYes099
74R:R:F533 R:R:W753 12.75973.01YesYes1199
75R:R:R680 R:R:W685 14.73842YesYes089
76R:R:L624 R:R:P663 15.25074.93YesYes099
77R:R:H620 R:R:L624 13.1073.86YesYes099
78R:R:H620 R:R:W685 17.12542.12YesYes1299
79R:R:W629 R:R:Y660 21.1714.82YesYes699
80R:R:Y621 R:R:Y660 21.18231.99YesYes069
81R:R:V667 R:R:Y621 11.60951.26NoYes096
82R:R:V667 R:R:Y678 11.07841.26NoYes099
83R:R:F771 R:R:G756 11.26216.02YesNo099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7YDJ
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRE5
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-G12)/Beta1/Gamma2
PDB Resolution 3.03
Date 2023-07-12
D.O.I. To be published
Net Summary
Imin 1.82
Number of Linked Nodes 815
Number of Links 946
Number of Hubs 134
Number of Links mediated by Hubs 498
Number of Communities 31
Number of Nodes involved in Communities 202
Number of Links involved in Communities 260
Path Summary
Number Of Nodes in MetaPath 84
Number Of Links MetaPath 83
Number of Shortest Paths 1197492
Length Of Smallest Path 3
Average Path Length 37.4537
Length of Longest Path 69
Minimum Path Strength 1.21
Average Path Strength 4.35908
Maximum Path Strength 22.1
Minimum Path Correlation 0.7
Average Path Correlation 0.981897
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.12766
Average % Of Corr. Nodes 39.9194
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.3345
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtQ03113
Sequence
>7YDJ_Chain_A
LSAEDKAAV ERSKMIDAL LARERRAVR RLVKILLLG ADNSGKSTF 
LKQMRIIHV KGIVEHDFV IKKIPFKMV DVSQRQKWF QCFDGITSI 
LFMVDSSDN RLVESMNDF ETIVNNKLF FNVSIILFL NKMDLLVEK 
VKTVSIKKH FPDFRGDPH RLEDVQRYL VQCFDRKRR NRSKPLFHH 
FTTSIDTEN ARFIFHAVK DTILQENLK DIML


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7YDJ_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7YDJ_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP48960
Sequence
>7YDJ_Chain_R
SSFAILMAH YDVEDWKLT LITRVGLAL SLFCLLLCI LTFLLVRPI 
QGSRTTIHL HLCICLFVG STIFLAGIE NEGGQVGLR CRLVAGLLH 
YCFLAAFCW MSLEGLELY FLVVRVFQG QGLSTRWLC LIGYGVPLL 
IVGVSAAIY SKGYGRPRY CWLDFEQGF LWSFLGPVT FIILCNAVI 
FVTTVWKLT QKFSEINPD MKKLKKARA LTITAIAQL FLLGCTWVF 
GLFIFDDRS LVLTYVFTI LNCLQGAFL YLLHCLLNK KVREEYRKW 
ACLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YDHB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi2-G13)/&β;1/&γ;23.12023-07-1210.1016/j.chembiol.2023.08.003
7YDJB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-G12)/&β;1/&γ;23.032023-07-12To be published
7YDMB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.892023-07-1210.1016/j.chembiol.2023.08.003
7YDPB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;23.12023-07-1210.1016/j.chembiol.2023.08.003
8IKJB2AdhesionAdhesionADGRE5Homo sapiens---3.22024-02-1410.1016/j.molcel.2023.12.020
8IKLB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1L-G13)/&β;1/&γ;22.332024-01-2410.1016/j.molcel.2023.12.020




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7YDJ.zip



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