Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 9.58857710
2M:M:?1 11.8640
3R:R:I49 5.4875406
4R:R:F55 6.372519
5R:R:V57 7.17416
6R:R:H58 6.968518
7R:R:K72 9.395414
8R:R:E73 5.168512
9R:R:K74 7.42715
10R:R:H77 7.995416
11R:R:R78 8.405614
12R:R:E80 6.15167618
13R:R:L95 5.0175407
14R:R:I99 5.4425405
15R:R:L101 5.2525409
16R:R:R104 4.25405
17R:R:D107 7.8325419
18R:R:C109 6.675417
19R:R:D112 8.7375404
20R:R:F122 6.264175
21R:R:S157 7.1425415
22R:R:S159 6.31419
23R:R:V161 3.6425404
24R:R:L171 5.295405
25R:R:P175 4.42408
26R:R:Q176 7.59408
27R:R:Y179 9.01418
28R:R:L186 9.19254188
29R:R:F194 7.054507
30R:R:F195 9.675188
31R:R:P200 7.108577
32R:R:D202 7.496508
33R:R:Q205 8.58479
34R:R:Q207 7.6525474
35R:R:W218 7.27286799
36R:R:Y220 5.772509
37R:R:Y230 10.92517
38R:R:E264 6.6403
39R:R:F265 7.5354204
40R:R:L272 5.675438
41R:R:V281 4.865436
42R:R:F284 6.784508
43R:R:D289 7.2285204
44R:R:R292 7.7854201
45R:R:L294 7.09435
46R:R:H305 10.7525433
47R:R:F306 8.548537
48R:R:F307 6.6475497
49R:R:W308 6.344537
50R:R:D312 6.9675478
51R:R:W314 4.83707
52R:R:V327 7.74433
53R:R:P336 7.868575
54R:R:F348 7.34517
55R:R:R351 9.166515
56R:R:N359 6.745417
57R:R:W361 7.702515
58R:R:F362 8.41415
59R:R:F365 10.966516
60R:R:N369 10.22413
61R:R:F370 12.4925418
62R:R:Q402 4.9945136
63R:R:E403 7.8675415
64R:R:K405 7.7275414
65R:R:F408 6.305407
66R:R:C428 4.75227
67R:R:Y449 8.736504
68R:R:F455 6.23509
69R:R:N468 6.8654197
70R:R:D470 10.63254197
71R:R:Y475 8.515678
72R:R:Q479 8.888598
73R:R:Y489 9.0154215
74R:R:I492 5.2975497
75R:R:W495 6.53575
76R:R:W508 11.0225498
77R:R:P516 7.9575498
78R:R:R529 10.11754246
79R:R:Y550 13.6575407
80R:R:M564 8.88754265
81R:R:K580 4.0325406
82R:R:P591 3.895408
83R:R:T615 5.13333609
84R:R:I633 5.3225409
85R:R:Y637 6.728508
86R:R:I644 4.4475408
87R:R:P647 4.392509
88R:R:R655 6.685408
89R:R:F658 5.6845276
90R:R:Y667 6.4775406
91R:R:T672 4.8775487
92R:R:R679 7.782587
93R:R:F681 6.7465299
94R:R:P691 7.125487
95R:R:T703 3.855487
96R:R:D721 4.385306
97R:R:L735 5.82254256
98R:R:R741 14.17754255
99R:R:V743 5.945406
100R:R:Y759 7.634288
101R:R:I787 5.815409
102R:R:F801 9.25609
103R:R:F805 15.1875408
104R:R:Y838 6.6445109
105R:R:K841 4.8475409
106R:R:L846 4.65754106
107S:S:F55 7.22254159
108S:S:H58 6.0975428
109S:S:K74 11.46545
110S:S:R78 10.4083644
111S:S:M82 4.8554158
112S:S:L101 5.566509
113S:S:D107 7.4325429
114S:S:C109 5.445427
115S:S:L116 4.89754145
116S:S:F122 5.0975405
117S:S:V151 5.184334
118S:S:V161 4.3475404
119S:S:M164 9.774145
120S:S:N167 5.03405
121S:S:I168 4.3975405
122S:S:Q176 5.834558
123S:S:D185 5.405454
124S:S:R191 11.415405
125S:S:F195 9.264558
126S:S:D202 8.725448
127S:S:Q205 10.7175449
128S:S:Q207 7.17754114
129S:S:V210 4.425406
130S:S:W218 9.974509
131S:S:Y220 6.098509
132S:S:Y230 9.416507
133S:S:I256 5.23405
134S:S:F265 9.92254354
135S:S:I269 2.51404
136S:S:F284 6.3525408
137S:S:E287 8.16403
138S:S:D289 5.45404
139S:S:L294 5.01405
140S:S:H305 7.9575403
141S:S:F306 7.2425407
142S:S:W308 4.98407
143S:S:D312 9.925448
144S:S:W314 8.176507
145S:S:H323 10.25401
146S:S:E329 10.48254365
147S:S:P336 7.5275405
148S:S:R351 10.0075405
149S:S:R358 6.7275404
150S:S:N359 5.9775427
151S:S:W361 7.93725
152S:S:F362 6.69425
153S:S:W366 8.616526
154S:S:F370 14.69428
155S:S:E392 10.7225427
156S:S:Q402 6.66406
157S:S:E403 7.155645
158S:S:K405 7.93833644
159S:S:F408 6.7025407
160S:S:M416 4.1925406
161S:S:Y449 6.19404
162S:S:I450 5.24407
163S:S:R451 5.865406
164S:S:F455 8.96509
165S:S:N461 2.82333605
166S:S:Y475 9.7825408
167S:S:Q479 5.3725408
168S:S:Y489 6.7325375
169S:S:W495 7.074115
170S:S:L499 4.9254117
171S:S:L501 4.9454117
172S:S:Q525 6.5265381
173S:S:Q549 4.7954397
174S:S:Y550 7.274407
175S:S:C560 5.1854409
176S:S:I576 8.32754168
177S:S:I599 3.19406
178S:S:R623 6.635408
179S:S:I633 3.5275409
180S:S:Y637 5.3508
181S:S:F641 4.615407
182S:S:T672 5.944127
183S:S:Q699 7.434128
184S:S:T703 3.1475407
185S:S:W717 7.455408
186S:S:F718 2.99407
187S:S:D721 4.5875406
188S:S:D731 8.2954166
189S:S:K745 6.95407
190S:S:Y759 6.3775408
191S:S:M761 6.4275406
192S:S:V777 4.9125408
193S:S:E783 6.5725409
194S:S:M791 4.6825409
195S:S:W798 8.6825469
196S:S:F801 7.2575469
197S:S:V826 3.5275408
198S:S:Y838 7.448336429
199X:X:?1 8.0681060
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:K405 38.44648.39YesYes104
2R:R:F408 R:R:K405 82.30616.2YesYes074
3R:R:F408 R:R:V198 98.71282.62YesNo079
4R:R:F465 R:R:V198 98.83752.62NoNo089
5R:R:F465 R:R:V453 49.48135.24NoNo087
6R:R:F455 R:R:V453 49.52335.24YesNo097
7R:R:F455 R:R:H418 10013.58YesNo096
8R:R:H418 R:R:L95 99.99826.43NoYes067
9R:R:I89 R:R:L95 99.98455.71NoYes097
10R:R:I89 R:R:L101 99.97884.28NoYes099
11R:R:I49 R:R:L101 99.80475.71YesYes069
12R:R:I49 R:R:L420 99.76525.71YesNo068
13R:R:L420 R:R:L446 99.75684.15NoNo086
14R:R:L446 R:R:P175 99.74846.57NoYes068
15R:R:F194 R:R:P175 99.67574.33YesYes078
16R:R:D193 R:R:F194 99.60479.55NoYes067
17R:R:D193 R:R:R170 99.59419.06NoNo065
18R:R:L171 R:R:R170 99.57234.86YesNo055
19R:R:L171 S:S:L116 99.50364.15YesYes055
20S:S:L116 S:S:M164 98.33954.24YesYes1455
21S:S:M164 S:S:N167 87.02784.21YesYes055
22S:S:N167 S:S:Y192 87.37214.65YesNo055
23S:S:I163 S:S:Y192 87.564610.88NoNo065
24S:S:I163 S:S:L186 87.26875.71NoNo568
25S:S:F195 S:S:L186 87.472513.4YesNo588
26S:S:F195 S:S:S162 39.90376.61YesNo587
27S:S:S162 S:S:S181 43.9666.52NoNo078
28S:S:S159 S:S:S181 83.63784.89NoNo098
29S:S:S159 S:S:Y230 83.47295.09NoYes097
30M:M:?1 S:S:Y230 76.55826.92YesYes007
31R:R:A415 R:R:F465 49.48132.77NoNo088
32R:R:A415 R:R:F455 49.52332.77NoYes089
33S:S:F195 S:S:S178 39.9135.28YesNo089
34S:S:S178 S:S:S181 39.83894.89NoNo098
35M:M:?1 S:S:K74 32.458610.79YesYes405
36M:M:?1 S:S:S313 30.460610.21YesNo006
37L:L:?1 R:R:S159 11.33718.94YesYes109
38R:R:S159 R:R:S181 11.04766.52YesNo098
39R:R:E403 R:R:R78 14.16076.98YesYes154
40L:L:?1 R:R:K74 26.27924.8YesYes105
41R:R:E287 R:R:K74 50.10026.75NoYes035
42R:R:E287 R:R:P320 49.74937.86NoNo035
43R:R:P320 R:R:W314 49.39835.4NoYes057
44R:R:I290 R:R:W314 10.48075.87NoYes047
45R:R:I283 R:R:I290 10.12785.89NoNo054
46R:R:F408 R:R:P336 18.06797.22YesYes075
47R:R:A331 R:R:W314 34.69491.3NoYes077
48R:R:A331 R:R:W308 34.34191.3NoYes077
49R:R:F306 R:R:W308 24.404714.03YesYes377
50R:R:F306 R:R:H305 16.81619.05YesYes373
51R:R:H305 R:R:R279 16.106313.54YesNo036
52R:R:F307 R:R:R279 15.74325.34YesNo076
53R:R:L272 R:R:Q252 10.25243.99YesNo086
54S:S:E287 S:S:K74 32.591813.5YesYes035
55S:S:E287 S:S:P320 62.71539.43YesNo035
56S:S:P320 S:S:W314 62.29888.11NoYes057
57S:S:I283 S:S:W314 55.61595.87NoYes057
58S:S:I283 S:S:V224 17.64234.61NoNo055
59S:S:E287 S:S:S313 30.26044.31YesNo036
60S:S:A278 S:S:S222 15.51871.71NoNo078
61S:S:A278 S:S:Y220 14.65772.67NoYes079
62S:S:I283 S:S:W308 37.75294.7NoYes057
63S:S:D112 S:S:M164 12.08619.41NoYes045
64S:S:D112 S:S:V161 11.98195.84NoYes044
65S:S:T108 S:S:V161 11.84344.76NoYes064
66S:S:L54 S:S:T108 11.79764.42NoNo066
67S:S:F122 S:S:L54 15.82184.87YesNo056
68S:S:F122 S:S:L106 14.95387.31YesNo055
69S:S:L106 S:S:Q118 14.579617.3NoNo055
70S:S:H114 S:S:Q118 14.454712.36NoNo035
71S:S:C109 S:S:H114 14.32967.37YesNo073
72S:S:F306 S:S:W308 28.44189.02YesYes077
73S:S:F306 S:S:H305 23.311711.31YesYes073
74S:S:H305 S:S:R279 22.03086.77YesNo036
75S:S:F307 S:S:R279 21.60239.62NoNo076
76S:S:F307 S:S:W218 14.29659.02NoYes079
77R:R:K405 R:R:R78 43.59049.9YesYes144
78R:R:K74 R:R:R78 25.57549.9YesYes154
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:?1 S:S:K74 10.79 4 Yes Yes 0 5 0 1
M:M:?1 S:S:R78 10.33 4 Yes Yes 0 4 0 1
M:M:?1 S:S:A180 5.36 4 Yes No 0 6 0 1
M:M:?1 S:S:Y230 26.92 4 Yes Yes 0 7 0 1
M:M:?1 S:S:S313 10.21 4 Yes No 0 6 0 1
M:M:?1 S:S:K405 7.19 4 Yes Yes 0 4 0 1
S:S:K71 S:S:K74 10.06 0 No Yes 5 5 2 1
S:S:K74 S:S:R78 14.85 4 Yes Yes 5 4 1 1
S:S:E287 S:S:K74 13.5 0 Yes Yes 3 5 2 1
S:S:E403 S:S:K74 8.1 4 Yes Yes 5 5 2 1
S:S:R78 S:S:Y179 9.26 4 Yes No 4 8 1 2
S:S:A180 S:S:R78 4.15 4 No Yes 6 4 1 1
S:S:E403 S:S:R78 13.96 4 Yes Yes 5 4 2 1
S:S:K405 S:S:R78 9.9 4 Yes Yes 4 4 1 1
S:S:S159 S:S:Y230 5.09 0 No Yes 9 7 2 1
S:S:A180 S:S:K405 6.42 4 No Yes 6 4 1 1
S:S:D202 S:S:Y230 6.9 4 Yes Yes 8 7 2 1
S:S:G231 S:S:Y230 4.35 0 No Yes 8 7 2 1
S:S:E287 S:S:S313 4.31 0 Yes No 3 6 2 1
S:S:D312 S:S:K405 11.06 4 Yes Yes 8 4 2 1
S:S:E403 S:S:K405 8.1 4 Yes Yes 5 4 2 1
S:S:F408 S:S:K405 4.96 0 Yes Yes 7 4 2 1
S:S:S311 S:S:Y230 3.82 0 No Yes 8 7 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I796 R:R:Y792 13.3 6 No No 8 9 2 2
R:R:Y792 S:S:L828 5.86 6 No No 9 6 2 1
R:R:I796 S:S:L828 4.28 6 No No 8 6 2 1
R:R:L799 X:X:?1 7.22 0 No Yes 6 0 1 0
R:R:I802 X:X:?1 5.32 0 No Yes 7 0 1 0
R:R:P803 X:X:?1 17.14 0 No Yes 9 0 1 0
S:S:L590 S:S:P591 4.93 0 No No 4 8 1 2
S:S:L590 X:X:?1 8.25 0 No Yes 4 0 1 0
S:S:P591 S:S:V824 5.3 0 No No 8 7 2 1
S:S:F801 S:S:W798 10.02 6 Yes Yes 9 9 2 2
S:S:S825 S:S:W798 4.94 6 No Yes 8 9 1 2
S:S:F801 S:S:S825 7.93 6 Yes No 9 8 2 1
S:S:I804 S:S:T821 9.12 6 No No 7 8 1 1
S:S:I804 X:X:?1 5.32 6 No Yes 7 0 1 0
S:S:T821 X:X:?1 4.4 6 No Yes 8 0 1 0
S:S:V824 X:X:?1 18.88 0 No Yes 7 0 1 0
S:S:S825 X:X:?1 6.72 6 No Yes 8 0 1 0
S:S:L828 X:X:?1 4.13 6 No Yes 6 0 1 0
R:R:F801 R:R:I802 3.77 0 Yes No 9 7 2 1
S:S:T820 X:X:?1 3.3 0 No Yes 8 0 1 0
R:R:A800 S:S:I804 3.25 0 No No 7 7 2 1
R:R:C795 R:R:L799 3.17 0 No No 6 6 2 1
S:S:I817 S:S:T820 3.04 0 No No 5 8 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:K74 4.8 1 Yes Yes 0 5 0 1
L:L:?1 R:R:R78 5.17 1 Yes Yes 0 4 0 1
L:L:?1 R:R:S159 8.94 1 Yes Yes 0 9 0 1
L:L:?1 R:R:T182 5.01 1 Yes No 0 8 0 1
L:L:?1 R:R:Y230 31.9 1 Yes Yes 0 7 0 1
L:L:?1 R:R:K405 8.39 1 Yes Yes 0 4 0 1
R:R:K74 R:R:P56 8.36 1 Yes No 5 5 1 2
R:R:P56 R:R:S157 7.13 1 No Yes 5 5 2 2
R:R:K71 R:R:K74 15.8 0 No Yes 5 5 2 1
R:R:K74 R:R:R78 9.9 1 Yes Yes 5 4 1 1
R:R:K74 R:R:S157 4.59 1 Yes Yes 5 5 1 2
R:R:E287 R:R:K74 6.75 0 No Yes 3 5 2 1
R:R:R78 R:R:S157 9.22 1 Yes Yes 4 5 1 2
R:R:R78 R:R:Y179 9.26 1 Yes Yes 4 8 1 2
R:R:E403 R:R:R78 6.98 1 Yes Yes 5 4 2 1
R:R:K405 R:R:R78 9.9 1 Yes Yes 4 4 1 1
R:R:S157 R:R:Y179 7.63 1 Yes Yes 5 8 2 2
R:R:S159 R:R:S181 6.52 1 Yes No 9 8 1 2
R:R:S159 R:R:Y230 6.36 1 Yes Yes 9 7 1 1
R:R:A180 R:R:K405 6.42 0 No Yes 6 4 2 1
R:R:D202 R:R:T182 8.67 0 Yes No 8 8 2 1
R:R:D312 R:R:T182 5.78 7 Yes No 8 8 2 1
R:R:D202 R:R:Y230 6.9 0 Yes Yes 8 7 2 1
R:R:G231 R:R:Y230 4.35 0 No Yes 8 7 2 1
R:R:S311 R:R:Y230 5.09 0 No Yes 8 7 2 1
R:R:F408 R:R:K405 6.2 0 Yes Yes 7 4 2 1
R:R:A183 R:R:S159 3.42 0 No Yes 7 9 2 1
L:L:?1 R:R:G158 2.91 1 Yes No 0 4 0 1
R:R:G75 R:R:K74 1.74 0 No Yes 5 5 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8JD6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 4.14
Number of Linked Nodes 1491
Number of Links 1615
Number of Hubs 199
Number of Links mediated by Hubs 739
Number of Communities 42
Number of Nodes involved in Communities 221
Number of Links involved in Communities 279
Path Summary
Number Of Nodes in MetaPath 79
Number Of Links MetaPath 78
Number of Shortest Paths 2060686
Length Of Smallest Path 3
Average Path Length 38.778
Length of Longest Path 78
Minimum Path Strength 1.095
Average Path Strength 7.0296
Maximum Path Strength 25.35
Minimum Path Correlation 0.7
Average Path Correlation 0.99651
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 6.06061
Average % Of Corr. Nodes 63.8479
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.0125
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • positive regulation of cell communication   • regulation of cellular process   • positive regulation of signal transduction   • response to stimulus   • signaling   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • cell communication   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • signal transduction   • positive regulation of cellular process   • regulation of biological process   • regulation of signaling   • positive regulation of MAPK cascade   • biological regulation   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • regulation of cell communication   • cellular process   • positive regulation of signaling   • cell surface receptor signaling pathway   • glutamate receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway   • G protein-coupled glutamate receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • trans-synaptic signaling   • synaptic signaling   • anterograde trans-synaptic signaling   • cell-cell signaling   • chemical synaptic transmission   • cellular localization   • neurotransmitter secretion   • transport   • secretion   • export from cell   • neurotransmitter transport   • establishment of localization   • localization   • signal release from synapse   • secretion by cell   • signal release   • establishment of localization in cell   • neuron apoptotic process   • regulation of apoptotic process   • regulation of programmed cell death   • cell death   • apoptotic process   • programmed cell death   • regulation of neuron apoptotic process   • modulation of chemical synaptic transmission   • synaptic transmission, glutamatergic   • regulation of synaptic transmission, glutamatergic   • regulation of trans-synaptic signaling   • membrane-bounded organelle   • intracellular organelle   • cellular anatomical structure   • intracellular anatomical structure   • cytoplasmic vesicle   • organelle   • intracellular vesicle   • cytoplasm   • intracellular membrane-bounded organelle   • vesicle   • cell periphery   • plasma membrane   • membrane   • presynapse
Gene OntologyCellular Component• membrane-bounded organelle   • intracellular organelle   • cellular anatomical structure   • intracellular anatomical structure   • cytoplasmic vesicle   • organelle   • intracellular vesicle   • cytoplasm   • intracellular membrane-bounded organelle   • vesicle   • cell periphery   • plasma membrane   • membrane   • presynapse   • synapse   • cell junction   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • extracellular membrane-bounded organelle   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • GDP binding   • G-protein beta/gamma-subunit complex binding   • signaling receptor binding   • G protein-coupled receptor binding   • cation binding   • metal ion binding   • cell division   • regulation of molecular function   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • positive regulation of autophagy   • catabolic process   • macroautophagy   • autophagy   • positive regulation of biological process   • regulation of catabolic process   • regulation of autophagy   • positive regulation of catabolic process   • positive regulation of metabolic process   • regulation of macroautophagy   • metabolic process   • positive regulation of macroautophagy   • process utilizing autophagic mechanism   • regulation of metabolic process   • positive regulation of cellular process   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • nucleoside phosphate metabolic process   • ribose phosphate metabolic process   • purine nucleoside triphosphate metabolic process   • GTP metabolic process   • carbohydrate derivative metabolic process   • primary metabolic process   • nucleotide metabolic process   • purine-containing compound metabolic process   • nucleobase-containing compound metabolic process   • purine nucleotide metabolic process   • ribonucleotide metabolic process   • organophosphate metabolic process   • nucleobase-containing small molecule metabolic process   • purine ribonucleoside triphosphate metabolic process   • phosphate-containing compound metabolic process   • small molecule metabolic process   • nucleoside triphosphate metabolic process   • purine ribonucleotide metabolic process   • phosphorus metabolic process   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body
SCOP2Domain Identifier• Ras-like P-loop GTPases
SCOP2Family Identifier• Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeSEP
PDB ResiduesL:L:?1 M:M:?1
Environment DetailsOpen EMBL-EBI Page
CodeSEP
NameDexfosfoserine
SynonymsPHOSPHONOSERINE
Identifier
FormulaC3 H8 N O6 P
Molecular Weight185.072
SMILES
PubChem68841
Formal Charge0
Total Atoms19
Total Chiral Atoms1
Total Bonds18
Total Aromatic Bonds0

CodeBK0
PDB ResiduesX:X:?1
Environment DetailsOpen EMBL-EBI Page
CodeBK0
NameN-(3-chlorophenyl)pyridine-2-carboxamide
Synonyms
Identifier
FormulaC12 H9 Cl N2 O
Molecular Weight232.666
SMILES
PubChem836002
Formal Charge0
Total Atoms25
Total Chiral Atoms0
Total Bonds26
Total Aromatic Bonds12

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ14833
Sequence
>8JD6_nogp_Chain_R
NSIRIDGDI TLGGLFPVH GRGSEGKPC GELKKEKGI HRLEAMLFA 
LDRINNDPD LLPNITLGA RILDTCSRD THALEQSLT FVQALIERV 
VGVIGASGS SVSIMVANI LRLFKIPQI SYASTAPDL SDNSRYDFF 
SRVVPSDTY QAQAMVDIV RALKWNYVS TVASEGSYG ESGVEAFIQ 
KSREDGGVC IAQSVKIPR EPKAGEFDK IIRRLLETS NARAVIIFA 
NEDDIRRVL EAARRANQT GHFFWMGSD SWGSKIAPV LHLEEVAEG 
AVTILPKRM SVRGFDRYF SSRTLDNNR RNIWFAEFW EDNFHCKLV 
KKCTNRERI GQDSAYEQE GKVQFVIDA VYAMGHALH AMHRDLCPG 
RVGLCPRMD PVDGTQLLK YIRNVNFSG IAGNPVTFN ENGDAPGRY 
DIYQYQLRA EYKVIGSWT DHLHLRIER MHWLPRSIC SLPCQPGER 
KKTVKGMPC CWHCEPCTG YQYQVDRYT CKTCPYDMR PTENRTGCR 
PIPIIKLEW GSPWAVLPL FLAVVGIAA TLFVVITFV RYNDTPIVK 
ASGRELSYV LLAGIFLCY ATTFLMIAE PDLGTCSLR RIFLGLGMS 
ISYAALLTK TNRIYRIFE QGKRSVSAP RFISPASQL AITFSLISL 
QLLGICVWF VVDPSHSVV DFQDQRTLD PRFARGVLK CDISDLSLI 
CLLGYSMLL MVTCTVYAI KTRGVPETF NEAKPIGFT MYTTCIVWL 
AFIPIFFGT SQSADKLYI QTTTLTVSV SLSASVSLG MLYMPKVYI 
ILFHPEQNV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ14833
Sequence
>8JD6_nogp_Chain_S
NSIRIDGDI TLGGLFPVH GRGSEGKPC GELKKEKGI HRLEAMLFA 
LDRINNDPD LLPNITLGA RILDTCSRD THALEQSLT FVQALERVV 
GVIGASGSS VSIMVANIL RLFKIPQIS YASTAPDLS DNSRYDFFS 
RVVPSDTYQ AQAMVDIVR ALKWNYVST VASEGSYGE SGVEAFIQK 
SREDGGVCI AQSVKIPRE PKAGEFDKI IRRLLETSN ARAVIIFAN 
EDDIRRVLE AARRANQTG HFFWMGSDS WGSKIAPVL HLEEVAEGA 
VTILPKRMS VRGFDRYFS SRTLDNNRR NIWFAEFWE DNFHCKKKC 
TNRERIGQD SAYEQEGKV QFVIDAVYA MGHALHAMH RDLCPGRVG 
LCPRMDPVD GTQLLKYIR NVNFSGIAG NPVTFNENG DAPGRYDIY 
QYQLRNDSA EYKVIGSWT DHLHLRIER MHWLPRSIC SLPCQPGER 
KKTVKGMPC CWHCEPCTG YQYQVDRYT CKTCPYDMR PTENRTGCR 
PIPIIKLEW GSPWAVLPL FLAVVGIAA TLFVVITFV RYNDTPIVK 
ASGRELSYV LLAGIFLCY ATTFLMIAE PDLGTCSLR RIFLGLGMS 
ISYAALLTK TNRIYRIFE QRFISPASQ LAITFSLIS LQLLGICVW 
FVVDPSHSV VDFQDQRTL DPRFARGVL KCDISDLSL ICLLGYSML 
LMVTCTVYA IKTRGVPET FNEAKPIGF TMYTTCIVW LAFIPIFFG 
TSQSADKLY IQTTTLTVS VSLSASVSL GMLYMPKVY IILFH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JD6CAminoacidMetabotropic GlutamatemGlu4; mGlu4Homo sapiensPhosphoserineVU0364770Gi3/β1/γ23.42023-06-21doi.org/10.1038/s41422-023-00830-2
8JD6 (No Gprot) CAminoacidMetabotropic GlutamatemGlu4; mGlu4Homo sapiensPhosphoserineVU03647703.42023-06-21doi.org/10.1038/s41422-023-00830-2
8WGBCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutammateVU0155041Gi3/β1/γ23.72024-10-30doi.org/10.1038/s41467-024-54744-7
8WGB (No Gprot) CAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutammateVU01550413.72024-10-30doi.org/10.1038/s41467-024-54744-7
8JD5CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateJNJ-40411813; ADX88178Gi1/β1/γ23.62023-06-21doi.org/10.1038/s41422-023-00830-2
8JD5 (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateJNJ-40411813; ADX881783.62023-06-21doi.org/10.1038/s41422-023-00830-2
8JD4CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamate--2.92023-06-21doi.org/10.1038/s41422-023-00830-2
8WG9CAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiens(2S)-2-amino-4-phosphonobutanoic acid--4.462024-11-27doi.org/10.1038/s41467-024-54744-7
8WGCCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensLY379268--5.952024-11-27doi.org/10.1038/s41467-024-54744-7
8WGDCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensWAG; WA6--4.452024-11-27doi.org/10.1038/s41467-024-54744-7
7E9HCAminoacidMetabotropic GlutamatemGlu4; mGlu4Homo sapiensPhosphoserine-Gi3/β1/γ242021-06-23doi.org/10.1038/s41586-021-03495-2
7E9H (No Gprot) CAminoacidMetabotropic GlutamatemGlu4; mGlu4Homo sapiensPhosphoserine-42021-06-23doi.org/10.1038/s41586-021-03495-2




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