psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C1	L:L:C6	7.28	No	No	0	0	0
2	L:L:C1	R:R:M311	3.24	No	Yes	0	0	5
3	L:L:C1	R:R:L312	4.76	No	No	0	0	4
4	L:L:Y2	R:R:Q92	11.27	Yes	Yes	1	0	6
5	L:L:Y2	R:R:Q96	6.76	Yes	No	0	0	7
6	L:L:Y2	R:R:F287	4.13	Yes	Yes	1	0	6
7	L:L:Y2	R:R:L312	5.86	Yes	No	0	0	4
8	L:L:Y2	R:R:A314	4	Yes	No	1	0	7
9	L:L:F3	R:R:M120	3.73	Yes	Yes	0	0	5
10	L:L:F3	R:R:V206	6.55	Yes	No	0	0	5
11	L:L:F3	R:R:F287	4.29	Yes	Yes	1	0	6
12	L:L:F3	R:R:F288	5.36	Yes	Yes	1	0	7
13	L:L:F3	R:R:Q291	12.88	Yes	Yes	1	0	6
14	L:L:Q4	R:R:Q291	10.24	Yes	Yes	1	0	6
15	L:L:Q4	R:R:A294	4.55	Yes	No	0	0	4
16	L:L:Q4	R:R:A295	4.55	Yes	No	0	0	5
17	L:L:Q4	R:R:M311	5.44	Yes	Yes	1	0	5
18	L:L:N5	R:R:C195	6.3	No	No	0	0	2
19	L:L:C6	L:L:P7	3.77	No	No	0	0	0
20	L:L:C6	R:R:K100	4.85	No	No	0	0	5
21	L:L:P7	R:R:E303	6.29	No	No	0	0	4
22	L:L:P7	R:R:M311	6.71	No	Yes	0	0	5
23	L:L:R8	R:R:T190	11.64	No	Yes	0	0	4
24	L:L:R8	R:R:W193	7	No	No	0	0	4
25	R:R:D33	R:R:P34	6.44	No	No	0	6	4
26	R:R:D33	R:R:L35	12.21	No	No	4	6	4
27	R:R:D33	R:R:L36	10.86	No	No	4	6	4
28	R:R:L35	R:R:L36	4.15	No	No	4	4	4
29	R:R:A305	R:R:L36	4.73	No	No	0	2	4
30	R:R:E40	R:R:K100	10.8	Yes	No	0	5	5
31	R:R:E40	R:R:L312	5.3	Yes	No	0	5	4
32	R:R:A101	R:R:L41	3.15	No	No	0	4	4
33	R:R:L313	R:R:L43	5.54	No	No	0	7	5
34	R:R:L44	R:R:V93	2.98	No	No	0	7	7
35	R:R:V47	R:R:V93	3.21	No	No	0	7	7
36	R:R:F48	R:R:V93	10.49	No	No	0	6	7
37	R:R:A89	R:R:V51	3.39	No	No	0	7	7
38	R:R:S318	R:R:V51	4.85	No	No	0	9	7
39	R:R:N55	R:R:S54	4.47	No	No	0	9	8
40	R:R:P322	R:R:S54	3.56	No	No	0	9	8
41	R:R:S54	R:R:W323	4.94	No	No	0	8	6
42	R:R:C82	R:R:N55	4.72	No	No	0	9	9
43	R:R:D85	R:R:N55	14.81	No	No	0	9	9
44	R:R:L57	R:R:V58	2.98	Yes	No	0	5	8
45	R:R:L57	R:R:W323	5.69	Yes	No	0	5	6
46	R:R:L336	R:R:L57	4.15	No	Yes	0	6	5
47	R:R:C82	R:R:V58	3.42	No	No	0	9	8
48	R:R:A61	R:R:L336	3.15	No	No	0	7	6
49	R:R:G79	R:R:L62	3.42	No	No	0	5	7
50	R:R:R64	R:R:R67	4.26	No	No	0	6	6
51	R:R:E335	R:R:R64	9.3	No	No	0	6	6
52	R:R:L339	R:R:R64	9.72	No	No	0	4	6
53	R:R:H75	R:R:R65	5.64	Yes	Yes	5	9	5
54	R:R:R65	R:R:S331	6.59	Yes	No	5	5	7
55	R:R:E335	R:R:R65	3.49	No	Yes	0	6	5
56	R:R:R67	R:R:R68	4.26	No	No	0	6	6
57	R:R:E335	R:R:R68	4.65	No	No	0	6	6
58	R:R:A72	R:R:H75	4.39	No	Yes	0	7	9
59	R:R:H75	R:R:I74	5.3	Yes	No	0	9	8
60	R:R:H75	R:R:S331	5.58	Yes	No	5	9	7
61	R:R:D136	R:R:F77	11.94	No	No	0	9	8
62	R:R:H80	R:R:N157	3.83	No	No	3	9	4
63	R:R:H80	R:R:V160	11.07	No	Yes	3	9	7
64	R:R:L81	R:R:N321	8.24	No	No	0	9	9
65	R:R:A84	R:R:M129	3.22	No	Yes	3	8	8
66	R:R:A84	R:R:W164	3.89	No	Yes	3	8	9
67	R:R:D85	R:R:S318	10.31	No	No	0	9	9
68	R:R:D85	R:R:N321	4.04	No	No	0	9	9
69	R:R:Q92	R:R:V88	4.3	Yes	Yes	1	6	7
70	R:R:G122	R:R:V88	3.68	No	Yes	0	8	7
71	R:R:S315	R:R:V88	3.23	No	Yes	1	7	7
72	R:R:S318	R:R:V88	3.23	No	Yes	0	9	7
73	R:R:F91	R:R:L118	6.09	No	No	0	4	5
74	R:R:M123	R:R:Q92	4.08	No	Yes	0	7	6
75	R:R:Q92	R:R:S315	5.78	Yes	No	1	6	7
76	R:R:L94	R:R:P95	3.28	No	No	0	8	5
77	R:R:P95	R:R:V115	3.53	No	No	0	5	5
78	R:R:Q96	R:R:W99	3.29	No	Yes	0	7	5
79	R:R:Q119	R:R:Q96	8.96	No	No	0	7	7
80	R:R:F105	R:R:W99	3.01	Yes	Yes	2	8	5
81	R:R:K116	R:R:W99	5.8	Yes	Yes	2	6	5
82	R:R:T190	R:R:W99	3.64	Yes	Yes	0	4	5
83	R:R:D191	R:R:W99	5.58	Yes	Yes	2	4	5
84	R:R:R106	R:R:T102	12.94	No	No	0	3	5
85	R:R:R104	R:R:R106	4.26	No	No	0	4	3
86	R:R:F105	R:R:G107	3.01	Yes	No	0	8	6
87	R:R:F105	R:R:R181	7.48	Yes	No	2	8	1
88	R:R:D191	R:R:F105	23.88	Yes	Yes	2	4	8
89	R:R:G107	R:R:P108	4.06	No	No	0	6	8
90	R:R:L111	R:R:P108	9.85	No	No	0	5	8
91	R:R:C112	R:R:F178	4.19	No	Yes	2	9	6
92	R:R:C112	R:R:D191	9.34	No	Yes	2	9	4
93	R:R:C112	R:R:C192	5.46	No	No	2	9	9
94	R:R:L175	R:R:R113	3.64	No	No	0	4	7
95	R:R:K116	R:R:Q119	6.78	Yes	No	0	6	7
96	R:R:K116	R:R:Q174	5.42	Yes	Yes	2	6	5
97	R:R:F178	R:R:K116	27.3	Yes	Yes	2	6	6
98	R:R:L168	R:R:Y117	3.52	No	Yes	0	4	5
99	R:R:S171	R:R:Y117	3.82	No	Yes	0	7	5
100	R:R:L172	R:R:Y117	9.38	No	Yes	0	4	5
101	R:R:L175	R:R:Y117	7.03	No	Yes	0	4	5
102	R:R:M120	R:R:Y124	4.79	Yes	Yes	0	5	7
103	R:R:M120	R:R:S171	6.13	Yes	No	0	5	7
104	R:R:M120	R:R:Q174	10.88	Yes	Yes	0	5	5
105	R:R:S167	R:R:V121	3.23	No	No	0	8	5
106	R:R:L168	R:R:V121	2.98	No	No	0	4	5
107	R:R:L170	R:R:Y124	12.89	Yes	Yes	0	4	7
108	R:R:I209	R:R:Y124	4.84	No	Yes	0	5	7
109	R:R:V213	R:R:Y124	3.79	No	Yes	0	5	7
110	R:R:A125	R:R:W164	6.48	No	Yes	0	7	9
111	R:R:A125	R:R:S167	3.42	No	No	0	7	8
112	R:R:S127	R:R:V213	3.23	No	No	0	8	5
113	R:R:P217	R:R:S127	3.56	No	No	1	9	8
114	R:R:S127	R:R:Y280	3.82	No	Yes	1	8	9
115	R:R:F166	R:R:Y128	7.22	No	No	0	3	6
116	R:R:M129	R:R:V160	3.04	Yes	Yes	3	8	7
117	R:R:M129	R:R:W164	3.49	Yes	Yes	3	8	9
118	R:R:M133	R:R:Y325	7.18	No	Yes	0	9	9
119	R:R:I221	R:R:T134	6.08	No	No	0	8	8
120	R:R:C224	R:R:T134	3.38	No	No	0	5	8
121	R:R:Q225	R:R:R137	4.67	No	No	0	9	9
122	R:R:I228	R:R:R137	3.76	No	No	0	8	9
123	R:R:M272	R:R:R137	4.96	No	No	0	8	9
124	R:R:C142	R:R:H138	8.85	No	Yes	0	6	8
125	R:R:C224	R:R:H138	5.9	No	Yes	0	5	8
126	R:R:H138	R:R:L227	6.43	Yes	No	0	8	4
127	R:R:H138	R:R:I228	3.98	Yes	No	0	8	8
128	R:R:C142	R:R:E231	6.08	No	No	0	6	5
129	R:R:L146	R:R:R143	6.07	No	No	0	5	6
130	R:R:M145	R:R:R149	3.72	No	No	0	7	4
131	R:R:L146	R:R:R149	3.64	No	No	0	5	4
132	R:R:N157	R:R:V160	4.43	No	Yes	3	4	7
133	R:R:F166	R:R:L170	4.87	No	Yes	0	3	4
134	R:R:L170	R:R:W208	4.56	Yes	No	0	4	3
135	R:R:F178	R:R:Q174	9.37	Yes	Yes	2	6	5
136	R:R:Q174	R:R:Y205	6.76	Yes	No	0	5	7
137	R:R:I177	R:R:Y205	8.46	No	No	0	5	7
138	R:R:C192	R:R:F178	5.59	No	Yes	2	9	6
139	R:R:C195	R:R:F178	6.98	No	Yes	0	2	6
140	R:R:N182	R:R:Q180	5.28	No	No	0	3	4
141	R:R:D191	R:R:R181	4.76	Yes	No	2	4	1
142	R:R:T190	R:R:V189	3.17	Yes	No	0	4	3
143	R:R:C192	R:R:D191	3.11	No	Yes	2	9	4
144	R:R:A194	R:R:W193	6.48	No	No	0	5	4
145	R:R:A197	R:R:E198	6.03	No	No	0	5	4
146	R:R:E198	R:R:P199	3.14	No	No	0	4	3
147	R:R:R203	R:R:W200	16.99	No	No	0	4	1
148	R:R:T204	R:R:W200	4.85	No	No	0	3	1
149	R:R:R203	R:R:W296	6	No	No	0	4	4
150	R:R:I209	R:R:Y205	13.3	No	No	0	5	7
151	R:R:A295	R:R:V206	5.09	No	No	0	5	5
152	R:R:I209	R:R:W208	4.7	No	No	0	5	3
153	R:R:M212	R:R:W208	8.14	No	No	0	3	3
154	R:R:A210	R:R:F288	4.16	No	Yes	0	5	7
155	R:R:L211	R:R:V215	2.98	No	No	0	5	4
156	R:R:F288	R:R:V213	3.93	Yes	No	0	7	5
157	R:R:F214	R:R:W284	7.02	No	Yes	0	8	8
158	R:R:P217	R:R:Y280	5.56	No	Yes	1	9	9
159	R:R:T218	R:R:Y280	3.75	No	Yes	0	6	9
160	R:R:Q225	R:R:T273	9.92	No	No	0	9	8
161	R:R:P238	R:R:V237	5.3	No	No	0	4	4
162	R:R:G239	R:R:P240	4.06	No	No	0	5	4
163	R:R:L274	R:R:V270	2.98	No	No	0	5	6
164	R:R:F328	R:R:R271	3.21	Yes	No	0	7	7
165	R:R:F328	R:R:M272	13.68	Yes	No	0	7	8
166	R:R:L274	R:R:T273	4.42	No	No	0	5	8
167	R:R:I324	R:R:V275	4.61	No	No	0	8	6
168	R:R:F328	R:R:V275	5.24	Yes	No	0	7	6
169	R:R:I276	R:R:Y325	8.46	No	Yes	0	8	9
170	R:R:T320	R:R:V279	3.17	No	No	0	6	6
171	R:R:I324	R:R:V279	4.61	No	No	0	8	6
172	R:R:W284	R:R:Y280	12.54	Yes	Yes	1	8	9
173	R:R:C283	R:R:N317	6.3	No	No	0	8	9
174	R:R:C283	R:R:T320	3.38	No	No	0	8	6
175	R:R:F287	R:R:W284	3.01	Yes	Yes	1	6	8
176	R:R:F288	R:R:W284	8.02	Yes	Yes	1	7	8
177	R:R:N317	R:R:W284	11.3	No	Yes	0	9	8
178	R:R:A285	R:R:P286	3.74	No	No	0	6	9
179	R:R:F287	R:R:F288	7.5	Yes	Yes	1	6	7
180	R:R:F287	R:R:Q291	12.88	Yes	Yes	1	6	6
181	R:R:A314	R:R:F287	8.32	No	Yes	1	7	6
182	R:R:L310	R:R:V290	4.47	No	No	0	5	5
183	R:R:M311	R:R:V290	4.56	Yes	No	0	5	5
184	R:R:M311	R:R:Q291	8.16	Yes	Yes	1	5	6
185	R:R:D297	R:R:W293	7.82	No	No	6	3	5
186	R:R:P301	R:R:W293	27.02	No	No	6	4	5
187	R:R:F307	R:R:W293	6.01	No	No	0	5	5
188	R:R:D297	R:R:P298	4.83	No	No	0	3	3
189	R:R:D297	R:R:P301	3.22	No	No	6	3	4
190	R:R:A300	R:R:E303	4.53	No	No	0	1	4
191	R:R:L302	R:R:P306	6.57	No	No	0	3	4
192	R:R:F307	R:R:L302	12.18	No	No	0	5	3
193	R:R:N321	R:R:P322	9.77	No	No	0	9	9
194	R:R:I324	R:R:Y325	3.63	No	Yes	0	8	9
195	R:R:S329	R:R:V332	3.23	No	No	0	8	8
196	R:R:L219	R:R:T218	2.95	No	No	0	3	6
197	R:R:I130	R:R:I221	2.94	No	No	0	8	8
198	R:R:I141	R:R:I228	2.94	No	No	0	8	8
199	R:R:P159	R:R:R158	2.88	No	No	0	6	3
200	R:R:Q119	R:R:V115	2.87	No	No	0	7	5
201	R:R:E40	R:R:V308	2.85	Yes	No	0	5	4
202	R:R:L41	R:R:L97	2.77	No	No	0	4	6
203	R:R:L309	R:R:L43	2.77	No	No	0	4	5
204	R:R:A89	R:R:F48	2.77	No	No	0	7	6
205	R:R:H75	R:R:V332	2.77	Yes	No	0	9	8
206	R:R:H80	R:R:V76	2.77	No	No	0	9	4
207	R:R:A132	R:R:F77	2.77	No	No	0	7	8
208	R:R:L86	R:R:L90	2.77	No	No	0	7	5
209	R:R:A147	R:R:Y148	2.67	No	No	0	6	6
210	R:R:E40	R:R:L41	2.65	Yes	No	0	5	4
211	R:R:F229	R:R:V266	2.62	No	Yes	0	5	7
212	R:R:F229	R:R:V270	2.62	No	No	0	5	6
213	R:R:F77	R:R:M133	2.49	No	No	0	8	9
214	R:R:V76	R:R:W71	2.45	No	No	0	4	7
215	R:R:F48	R:R:L90	2.44	No	No	0	6	5
216	R:R:F91	R:R:L90	2.44	No	No	0	4	5
217	R:R:L146	R:R:R139	2.43	No	No	0	5	5
218	R:R:T207	R:R:W296	2.43	No	No	0	5	4
219	R:R:L227	R:R:R230	2.43	No	No	0	4	4
220	R:R:I78	R:R:Y325	2.42	No	Yes	0	8	9
221	L:L:Q4	R:R:R202	2.34	Yes	No	0	0	4
222	R:R:H75	R:R:W71	2.12	Yes	No	0	9	7
223	R:R:G304	R:R:P306	2.03	No	No	0	4	4
224	R:R:C82	R:R:G79	1.96	No	No	0	9	5
225	R:R:A72	R:R:P73	1.87	No	No	0	7	7
226	R:R:A216	R:R:P217	1.87	No	No	0	5	9
227	R:R:A300	R:R:P301	1.87	No	No	0	1	4
228	R:R:A305	R:R:P306	1.87	No	No	0	2	4
229	L:L:G9	R:R:V308	1.84	No	No	0	0	4
230	R:R:A179	R:R:C195	1.81	No	No	0	4	2
231	R:R:C319	R:R:V51	1.71	No	No	0	7	7
232	R:R:G79	R:R:L59	1.71	No	No	0	5	7
233	R:R:G220	R:R:L131	1.71	No	No	0	6	7
234	R:R:G220	R:R:L219	1.71	No	No	0	6	3
235	R:R:A326	R:R:V332	1.7	No	No	0	7	8
236	R:R:I177	R:R:P173	1.69	No	No	0	5	8
237	R:R:E198	R:R:G201	1.64	No	No	0	4	3
238	R:R:L310	R:R:P286	1.64	No	No	0	5	9
239	R:R:S333	R:R:S334	1.63	No	No	0	8	5
240	R:R:S126	R:R:V88	1.62	No	Yes	0	9	7
241	R:R:A163	R:R:M129	1.61	No	Yes	0	7	8
242	R:R:V278	R:R:V279	1.6	No	No	0	4	6
243	R:R:C224	R:R:L135	1.59	No	No	0	5	6
244	R:R:T218	R:R:V281	1.59	No	No	0	6	5
245	R:R:C341	R:R:L340	1.59	No	No	0	3	7
246	R:R:T269	R:R:T273	1.57	No	No	0	7	8
247	R:R:I46	R:R:S45	1.55	No	No	0	4	5
248	R:R:A37	R:R:D103	1.54	No	No	0	5	5
249	R:R:A110	R:R:D109	1.54	No	No	0	2	4
250	R:R:I221	R:R:V277	1.54	No	No	0	8	8
251	R:R:I232	R:R:V266	1.54	No	Yes	0	9	7
252	R:R:L97	R:R:S45	1.5	No	No	0	6	5
253	R:R:G66	R:R:R65	1.5	No	Yes	0	8	5
254	R:R:L339	R:R:S338	1.5	No	No	0	4	5
255	R:R:L53	R:R:V49	1.49	No	No	0	4	5
256	R:R:L161	R:R:V160	1.49	No	Yes	0	2	7
257	R:R:L292	R:R:V206	1.49	No	No	0	5	5
258	R:R:L236	R:R:V266	1.49	No	Yes	0	4	7
259	R:R:L292	R:R:T207	1.47	No	No	0	5	5
260	R:R:P144	R:R:R143	1.44	No	No	0	9	6
261	R:R:E231	R:R:S235	1.44	No	No	0	5	6
262	R:R:L211	R:R:M212	1.41	No	No	0	5	3
263	R:R:L53	R:R:L57	1.38	No	Yes	0	4	5
264	R:R:L169	R:R:L170	1.38	No	Yes	0	4	4
265	R:R:H233	R:R:V266	1.38	No	Yes	0	4	7
266	R:R:A267	R:R:R271	1.38	No	No	0	6	7
267	R:R:L309	R:R:L310	1.38	No	No	0	4	5
268	R:R:L313	R:R:L316	1.38	No	No	0	7	6
269	R:R:P199	R:R:W200	1.35	No	No	0	3	1
270	R:R:F328	R:R:S327	1.32	Yes	No	0	7	5
271	R:R:R158	R:R:V162	1.31	No	No	0	3	3
272	R:R:A87	R:R:W164	1.3	No	Yes	0	6	9
273	R:R:R104	R:R:T190	1.29	No	Yes	0	4	4
274	R:R:L340	R:R:R337	1.21	No	No	0	7	5
275	R:R:D109	R:R:R113	1.19	No	No	0	4	7
276	R:R:L83	R:R:W164	1.14	No	Yes	0	6	9
277	R:R:H138	R:R:R143	1.13	Yes	No	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y2	6.404	5	1	0
2	L:L:F3	6.562	5	1	0
3	L:L:Q4	5.424	5	1	0
4	R:R:E40	5.4	4	0	5
5	R:R:L57	3.55	4	0	5
6	R:R:R65	4.305	4	5	5
7	R:R:H75	4.3	6	5	9
8	R:R:V88	3.212	5	1	7
9	R:R:Q92	6.3575	4	1	6
10	R:R:W99	4.264	5	2	5
11	R:R:F105	9.345	4	2	8
12	R:R:K116	11.325	4	2	6
13	R:R:Y117	5.9375	4	0	5
14	R:R:M120	6.3825	4	0	5
15	R:R:Y124	6.5775	4	0	7
16	R:R:M129	2.84	4	3	8
17	R:R:H138	5.258	5	0	8
18	R:R:V160	5.0075	4	3	7
19	R:R:W164	3.26	5	3	9
20	R:R:L170	5.925	4	0	4
21	R:R:Q174	8.1075	4	2	5
22	R:R:F178	10.686	5	2	6
23	R:R:T190	4.935	4	0	4
24	R:R:D191	9.334	5	2	4
25	R:R:V266	1.7575	4	0	7
26	R:R:Y280	6.4175	4	1	9
27	R:R:W284	8.378	5	1	8
28	R:R:F287	6.68833	6	1	6
29	R:R:F288	5.794	5	1	7
30	R:R:Q291	11.04	4	1	6
31	R:R:M311	5.622	5	1	5
32	R:R:Y325	5.4225	4	0	9
33	R:R:F328	5.8625	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C1	R:R:M311	15.6702	3.24	No	Yes	0	0	5
2	R:R:M311	R:R:Q291	43.115	8.16	Yes	Yes	1	5	6
3	R:R:F287	R:R:Q291	29.7264	12.88	Yes	Yes	1	6	6
4	L:L:C1	R:R:L312	21.8106	4.76	No	No	0	0	4
5	L:L:Y2	R:R:L312	37.7008	5.86	Yes	No	0	0	4
6	L:L:F3	R:R:Q291	19.9178	12.88	Yes	Yes	1	0	6
7	L:L:F3	R:R:M120	92.8472	3.73	Yes	Yes	0	0	5
8	L:L:F3	R:R:V206	28.039	6.55	Yes	No	0	0	5
9	L:L:F3	R:R:F288	29.9098	5.36	Yes	Yes	1	0	7
10	L:L:Y2	R:R:F287	85.2689	4.13	Yes	Yes	1	0	6
11	R:R:M120	R:R:Q174	30.0932	10.88	Yes	Yes	0	5	5
12	R:R:F178	R:R:Q174	12.1121	9.37	Yes	Yes	2	6	5
13	L:L:Y2	R:R:Q96	40.8114	6.76	Yes	No	0	0	7
14	R:R:Q96	R:R:W99	30.46	3.29	No	Yes	0	7	5
15	R:R:K116	R:R:W99	13.4253	5.8	Yes	Yes	2	6	5
16	R:R:Q119	R:R:Q96	10.5495	8.96	No	No	0	7	7
17	L:L:C1	L:L:C6	10.4908	7.28	No	No	0	0	0
18	L:L:C6	L:L:P7	10.6082	3.77	No	No	0	0	0
19	L:L:P7	R:R:M311	37.0259	6.71	No	Yes	0	0	5
20	L:L:P7	R:R:E303	41.2589	6.29	No	No	0	0	4
21	R:R:T190	R:R:W99	17.4822	3.64	Yes	Yes	0	4	5
22	R:R:A300	R:R:E303	38.6105	4.53	No	No	0	1	4
23	R:R:A300	R:R:P301	35.9475	1.87	No	No	0	1	4
24	R:R:P301	R:R:W293	27.7236	27.02	No	No	6	4	5
25	R:R:F307	R:R:W293	25.1486	6.01	No	No	0	5	5
26	R:R:F307	R:R:L302	22.4121	12.18	No	No	0	5	3
27	R:R:L302	R:R:P306	19.6611	6.57	No	No	0	3	4
28	R:R:A305	R:R:P306	14.1149	1.87	No	No	0	2	4
29	R:R:A305	R:R:L36	11.3198	4.73	No	No	0	2	4
30	R:R:E40	R:R:L312	16.4478	5.3	Yes	No	0	5	4
31	R:R:M311	R:R:V290	18.7734	4.56	Yes	No	0	5	5
32	R:R:L310	R:R:V290	16.4771	4.47	No	No	0	5	5
33	L:L:Y2	R:R:Q92	81.3	11.27	Yes	Yes	1	0	6
34	R:R:Q92	R:R:V88	75.8052	4.3	Yes	Yes	1	6	7
35	R:R:S318	R:R:V88	70.6404	3.23	No	Yes	0	9	7
36	R:R:S318	R:R:V51	24.7671	4.85	No	No	0	9	7
37	R:R:A89	R:R:V51	20.3947	3.39	No	No	0	7	7
38	R:R:A89	R:R:F48	18.1865	2.77	No	No	0	7	6
39	R:R:D85	R:R:S318	47.5754	10.31	No	No	0	9	9
40	R:R:D85	R:R:N55	39.1094	14.81	No	No	0	9	9
41	R:R:N55	R:R:S54	15.3107	4.47	No	No	0	9	8
42	R:R:S54	R:R:W323	13.2345	4.94	No	No	0	8	6
43	R:R:C82	R:R:N55	21.9353	4.72	No	No	0	9	9
44	R:R:L57	R:R:W323	11.0557	5.69	Yes	No	0	5	6
45	R:R:C82	R:R:V58	13.2492	3.42	No	No	0	9	8
46	R:R:L57	R:R:V58	11.063	2.98	Yes	No	0	5	8
47	R:R:M120	R:R:S171	82.4518	6.13	Yes	No	0	5	7
48	R:R:S171	R:R:Y117	80.6764	3.82	No	Yes	0	7	5
49	R:R:L168	R:R:Y117	69.7161	3.52	No	Yes	0	4	5
50	R:R:L168	R:R:V121	67.838	2.98	No	No	0	4	5
51	R:R:S167	R:R:V121	65.9453	3.23	No	No	0	8	5
52	R:R:A125	R:R:S167	64.0379	3.42	No	No	0	7	8
53	R:R:A125	R:R:W164	62.1158	6.48	No	Yes	0	7	9
54	R:R:M129	R:R:W164	54.0973	3.49	Yes	Yes	3	8	9
55	R:R:M129	R:R:V160	50.2751	3.04	Yes	Yes	3	8	7
56	R:R:H80	R:R:V160	44.01	11.07	No	Yes	3	9	7
57	R:R:H80	R:R:V76	42.0879	2.77	No	No	0	9	4
58	R:R:V76	R:R:W71	40.0044	2.45	No	No	0	4	7
59	R:R:H75	R:R:W71	37.9062	2.12	Yes	No	0	9	7
60	R:R:H75	R:R:R65	20.5267	5.64	Yes	Yes	5	9	5
61	R:R:E335	R:R:R65	16.1177	3.49	No	Yes	0	6	5
62	R:R:F287	R:R:W284	77.7713	3.01	Yes	Yes	1	6	8
63	R:R:N317	R:R:W284	100	11.3	No	Yes	0	9	8
64	R:R:C283	R:R:N317	98.3493	6.3	No	No	0	8	9
65	R:R:C283	R:R:T320	96.684	3.38	No	No	0	8	6
66	R:R:T320	R:R:V279	95.004	3.17	No	No	0	6	6
67	R:R:I324	R:R:V279	91.578	4.61	No	No	0	8	6
68	R:R:I324	R:R:Y325	16.2351	3.63	No	Yes	0	8	9
69	R:R:F105	R:R:W99	10.8576	3.01	Yes	Yes	2	8	5
70	R:R:M120	R:R:Y124	19.6977	4.79	Yes	Yes	0	5	7
71	R:R:L170	R:R:Y124	16.3671	12.89	Yes	Yes	0	4	7
72	R:R:I209	R:R:Y124	10.997	4.84	No	Yes	0	5	7
73	R:R:F288	R:R:V213	15.0539	3.93	Yes	No	0	7	5
74	R:R:W284	R:R:Y280	16.7486	12.54	Yes	Yes	1	8	9
75	R:R:I324	R:R:V275	77.3604	4.61	No	No	0	8	6
76	R:R:F328	R:R:V275	75.5264	5.24	Yes	No	0	7	6
77	R:R:F328	R:R:M272	67.9921	13.68	Yes	No	0	7	8
78	R:R:M272	R:R:R137	66.07	4.96	No	No	0	8	9
79	R:R:I228	R:R:R137	44.2961	3.76	No	No	0	8	9
80	R:R:H138	R:R:I228	40.2465	3.98	Yes	No	0	8	8
81	R:R:C224	R:R:H138	13.9902	5.9	No	Yes	0	5	8
82	R:R:Q225	R:R:R137	22.867	4.67	No	No	0	9	9
83	R:R:H138	R:R:R143	13.8361	1.13	Yes	No	0	8	6
84	R:R:L292	R:R:V206	26.183	1.49	No	No	0	5	5
85	R:R:L292	R:R:T207	23.63	1.47	No	No	0	5	5
86	R:R:T207	R:R:W296	21.0623	2.43	No	No	0	5	4
87	R:R:R203	R:R:W296	18.4799	6	No	No	0	4	4
88	R:R:R203	R:R:W200	15.8829	16.99	No	No	0	4	1
89	R:R:P199	R:R:W200	10.6449	1.35	No	No	0	3	1
90	R:R:M212	R:R:W208	12.3395	8.14	No	No	0	3	3
91	R:R:T218	R:R:Y280	13.2712	3.75	No	Yes	0	6	9
92	R:R:Q225	R:R:T273	20.6441	9.92	No	No	0	9	8
93	R:R:L274	R:R:T273	16.125	4.42	No	No	0	5	8
94	R:R:L274	R:R:V270	13.8434	2.98	No	No	0	5	6
95	R:R:F229	R:R:V270	11.5472	2.62	No	No	0	5	6
96	R:R:K116	R:R:Q174	15.7068	5.42	Yes	Yes	2	6	5
97	L:L:F3	R:R:F287	57.9561	4.29	Yes	Yes	1	0	6
98	R:R:V213	R:R:Y124	17.3722	3.79	No	Yes	0	5	7
99	R:R:F288	R:R:W284	35.3679	8.02	Yes	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C1	R:R:M311	3.24	0	No	Yes	0	5	0	1
L:L:C1	R:R:L312	4.76	0	No	No	0	4	0	1
L:L:Y2	R:R:Q92	11.27	1	Yes	Yes	0	6	0	1
L:L:Y2	R:R:Q96	6.76	1	Yes	No	0	7	0	1
L:L:Y2	R:R:F287	4.13	1	Yes	Yes	0	6	0	1
L:L:Y2	R:R:L312	5.86	1	Yes	No	0	4	0	1
L:L:Y2	R:R:A314	4	1	Yes	No	0	7	0	1
L:L:F3	R:R:M120	3.73	1	Yes	Yes	0	5	0	1
L:L:F3	R:R:V206	6.55	1	Yes	No	0	5	0	1
L:L:F3	R:R:F287	4.29	1	Yes	Yes	0	6	0	1
L:L:F3	R:R:F288	5.36	1	Yes	Yes	0	7	0	1
L:L:F3	R:R:Q291	12.88	1	Yes	Yes	0	6	0	1
L:L:Q4	R:R:Q291	10.24	1	Yes	Yes	0	6	0	1
L:L:Q4	R:R:A294	4.55	1	Yes	No	0	4	0	1
L:L:Q4	R:R:A295	4.55	1	Yes	No	0	5	0	1
L:L:Q4	R:R:M311	5.44	1	Yes	Yes	0	5	0	1
L:L:N5	R:R:C195	6.3	0	No	No	0	2	0	1
L:L:C6	R:R:K100	4.85	0	No	No	0	5	0	1
L:L:P7	R:R:E303	6.29	0	No	No	0	4	0	1
L:L:P7	R:R:M311	6.71	0	No	Yes	0	5	0	1
L:L:R8	R:R:T190	11.64	0	No	Yes	0	4	0	1
L:L:R8	R:R:W193	7	0	No	No	0	4	0	1
R:R:E40	R:R:K100	10.8	0	Yes	No	5	5	2	1
R:R:E40	R:R:L312	5.3	0	Yes	No	5	4	2	1
R:R:Q92	R:R:V88	4.3	1	Yes	Yes	6	7	1	2
R:R:S315	R:R:V88	3.23	1	No	Yes	7	7	2	2
R:R:M123	R:R:Q92	4.08	0	No	Yes	7	6	2	1
R:R:Q92	R:R:S315	5.78	1	Yes	No	6	7	1	2
R:R:Q96	R:R:W99	3.29	0	No	Yes	7	5	1	2
R:R:Q119	R:R:Q96	8.96	0	No	No	7	7	2	1
R:R:T190	R:R:W99	3.64	0	Yes	Yes	4	5	1	2
R:R:M120	R:R:Y124	4.79	0	Yes	Yes	5	7	1	2
R:R:M120	R:R:S171	6.13	0	Yes	No	5	7	1	2
R:R:M120	R:R:Q174	10.88	0	Yes	Yes	5	5	1	2
R:R:V213	R:R:Y124	3.79	0	No	Yes	5	7	2	2
R:R:F178	R:R:Q174	9.37	2	Yes	Yes	6	5	2	2
R:R:C195	R:R:F178	6.98	0	No	Yes	2	6	1	2
R:R:T190	R:R:V189	3.17	0	Yes	No	4	3	1	2
R:R:A194	R:R:W193	6.48	0	No	No	5	4	2	1
R:R:A295	R:R:V206	5.09	0	No	No	5	5	1	1
R:R:A210	R:R:F288	4.16	0	No	Yes	5	7	2	1
R:R:F288	R:R:V213	3.93	1	Yes	No	7	5	1	2
R:R:F287	R:R:W284	3.01	1	Yes	Yes	6	8	1	2
R:R:F288	R:R:W284	8.02	1	Yes	Yes	7	8	1	2
R:R:F287	R:R:F288	7.5	1	Yes	Yes	6	7	1	1
R:R:F287	R:R:Q291	12.88	1	Yes	Yes	6	6	1	1
R:R:A314	R:R:F287	8.32	1	No	Yes	7	6	1	1
R:R:M311	R:R:V290	4.56	1	Yes	No	5	5	1	2
R:R:M311	R:R:Q291	8.16	1	Yes	Yes	5	6	1	1
R:R:A300	R:R:E303	4.53	0	No	No	1	4	2	1
R:R:E40	R:R:V308	2.85	0	Yes	No	5	4	2	1
L:L:Q4	R:R:R202	2.34	1	Yes	No	0	4	0	1
L:L:G9	R:R:V308	1.84	0	No	No	0	4	0	1
R:R:A179	R:R:C195	1.81	0	No	No	4	2	2	1
R:R:L292	R:R:V206	1.49	0	No	No	5	5	2	1
R:R:R104	R:R:T190	1.29	0	No	Yes	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7KH0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	255
Number of Links	277
Number of Hubs	33
Number of Links mediated by Hubs	119
Number of Communities	6
Number of Nodes involved in Communities	39
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	100
Number Of Links MetaPath	99
Number of Shortest Paths	40366
Length Of Smallest Path	3
Average Path Length	15.2845
Length of Longest Path	38
Minimum Path Strength	1.22
Average Path Strength	5.62226
Maximum Path Strength	17.14
Minimum Path Correlation	0.7
Average Path Correlation	0.937624
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.85714
Average % Of Corr. Nodes	53.5699
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.9343
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • GDP binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • D1 dopamine receptor binding • dopamine receptor binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cellular process • cell division • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of molecular function • regulation of adenylate cyclase activity
Gene Ontology	Biological Process	• cellular process • cell division • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • positive regulation of autophagy • catabolic process • macroautophagy • autophagy • positive regulation of biological process • regulation of catabolic process • regulation of autophagy • positive regulation of catabolic process • positive regulation of metabolic process • regulation of macroautophagy • metabolic process • positive regulation of macroautophagy • process utilizing autophagic mechanism • regulation of metabolic process • positive regulation of cellular process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • nucleoside phosphate metabolic process • ribose phosphate metabolic process • purine nucleoside triphosphate metabolic process • GTP metabolic process • carbohydrate derivative metabolic process • primary metabolic process • nucleotide metabolic process • purine-containing compound metabolic process • nucleobase-containing compound metabolic process • purine nucleotide metabolic process • ribonucleotide metabolic process • organophosphate metabolic process • nucleobase-containing small molecule metabolic process • purine ribonucleoside triphosphate metabolic process • phosphate-containing compound metabolic process • small molecule metabolic process • nucleoside triphosphate metabolic process • purine ribonucleotide metabolic process • phosphorus metabolic process • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adenylate cyclase-activating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytoplasm • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • signaling receptor binding • vasopressin receptor binding • V1B vasopressin receptor binding • G protein-coupled receptor binding • molecular function activator activity • neuropeptide activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • neurohypophyseal hormone activity • V1A vasopressin receptor binding • catalytic activity, acting on a protein • kinase activity • protein kinase activity • transferase activity • catalytic activity • phosphotransferase activity, alcohol group as acceptor • transferase activity, transferring phosphorus-containing groups • regulation of growth • regulation of cellular component organization • growth • positive regulation of biological process • positive regulation of cell growth • regulation of cell growth • cell growth • cellular component organization • positive regulation of growth • cellular component organization or biogenesis • positive regulation of cellular process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • behavior • multicellular organismal process • locomotory behavior • reproductive process • negative regulation of female receptivity • multicellular organismal reproductive process • female mating behavior • mating behavior • regulation of female receptivity • reproductive behavior • system process • negative regulation of nervous system process • nervous system process • regulation of system process • negative regulation of biological process • transmission of nerve impulse • negative regulation of transmission of nerve impulse • negative regulation of cell communication • regulation of nervous system process • regulation of transmission of nerve impulse • negative regulation of cellular process • regulation of cell communication • regulation of multicellular organismal process • negative regulation of multicellular organismal process • regulation of tube diameter • regulation of tube size • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • response to testosterone • biological process involved in interspecies interaction between organisms • symbiont entry into host cell • viral process • symbiont entry into host • viral life cycle • biological process involved in interaction with host • biological process involved in symbiotic interaction • maternal behavior • parental behavior • regulation of body fluid levels • multicellular organismal-level homeostasis • chemical homeostasis • homeostatic process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • cell-cell signaling • localization • transport • fluid transport • establishment of localization • water transport • generation of precursor metabolites and energy • positive regulation of cellular pH reduction • intracellular pH reduction • regulation of intracellular pH • cellular homeostasis • regulation of cellular pH reduction • intracellular monoatomic cation homeostasis • regulation of pH • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • regulation of cellular pH • intracellular monoatomic ion homeostasis • response to ethanol • prostaglandin metabolic process • unsaturated fatty acid metabolic process • oxoacid metabolic process • regulation of lipid metabolic process • organic acid biosynthetic process • organic acid metabolic process • carboxylic acid biosynthetic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • positive regulation of prostaglandin biosynthetic process • small molecule metabolic process • prostaglandin biosynthetic process • primary metabolic process • regulation of ketone metabolic process • regulation of fatty acid metabolic process • regulation of fatty acid biosynthetic process • monocarboxylic acid metabolic process • positive regulation of unsaturated fatty acid biosynthetic process • regulation of prostaglandin biosynthetic process • icosanoid metabolic process • ketone metabolic process • regulation of unsaturated fatty acid biosynthetic process • lipid biosynthetic process • positive regulation of fatty acid biosynthetic process • prostanoid metabolic process • icosanoid biosynthetic process • prostanoid biosynthetic process • positive regulation of fatty acid metabolic process • fatty acid metabolic process • monocarboxylic acid biosynthetic process • small molecule biosynthetic process • carboxylic acid metabolic process • fatty acid biosynthetic process • unsaturated fatty acid biosynthetic process • positive regulation of lipid biosynthetic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • lipid metabolic process • positive regulation of cell population proliferation • regulation of cell population proliferation • maternal aggressive behavior • aggressive behavior • biological process involved in intraspecies interaction between organisms • social behavior • intracellular signal transduction • positive regulation of systemic arterial blood pressure • regulation of systemic arterial blood pressure • regulation of blood pressure • positive regulation of blood pressure • response to nicotine • regulation of localization • nitrogen compound transport • regulation of glutamate secretion • positive regulation of secretion by cell • positive regulation of amine transport • secretion by cell • regulation of secretion by cell • positive regulation of secretion • regulation of amino acid transport • glutamate secretion • organic anion transport • carboxylic acid transport • secretion • regulation of transport • positive regulation of glutamate secretion • export from cell • regulation of secretion • positive regulation of organic acid transport • organic acid transport • amino acid transport • amine transport • acidic amino acid transport • positive regulation of transport • positive regulation of amino acid transport • regulation of organic acid transport • dicarboxylic acid transport • regulation of amine transport • grooming behavior • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • somatodendritic compartment • dendrite • dendritic tree • neuron projection • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vasopressin receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • hemostasis • response to peptide • response to cytokine • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • endocrine process • regulation of systemic arterial blood pressure by vasopressin • positive regulation of cell communication • regulation of signaling • positive regulation of signal transduction • positive regulation of intracellular signal transduction • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of response to stimulus • positive regulation of signaling • renal system process • regulation of urine volume • renal water retention • negative regulation of urine volume • head development • forebrain development • brain development • nervous system development • central nervous system development • telencephalon development • negative regulation of cell population proliferation • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • endosome • perinuclear region of cytoplasm • endoplasmic reticulum
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30518
Sequence	>7KH0_nogp_Chain_R R D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G H W A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D R F R G P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R P M L A Y R N R P V L V A W A F S L L L S L P Q L F I F A Q R N V T D C W A C F A E P W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D P E A P L E G A P F V L L M L L A S L N S C T N P W I Y A S F S S S V S S E L R S L L C C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9V2N	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Macimorelin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.63	2025-07-02	doi.org/10.1038/s41401-025-01606-7
	9V2N (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Macimorelin	-		2.63	2025-07-02	doi.org/10.1038/s41401-025-01606-7
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	doi.org/10.1126/science.1215904
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	doi.org/10.1126/science.1215904
	7DW9	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	chim(NtGi1-Gs)/β1/γ2	2.6	2021-07-21	doi.org/10.1038/s41422-021-00480-2
	7DW9 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		2.6	2021-07-21	doi.org/10.1038/s41422-021-00480-2
	7KH0	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	chim(NtGi1-Gs)/β1/γ2	2.8	2021-05-26	doi.org/10.1038/s41422-021-00483-z
	7KH0 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		2.8	2021-05-26	doi.org/10.1038/s41422-021-00483-z
	7BB6	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Gs/β1/γ2	4.2	2021-06-02	doi.org/10.1126/sciadv.abg5628
	7BB6 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		4.2	2021-06-02	doi.org/10.1126/sciadv.abg5628
	7BB7	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Gs/β1/γ2	4.4	2021-06-02	doi.org/10.1126/sciadv.abg5628
	7BB7 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		4.4	2021-06-02	doi.org/10.1126/sciadv.abg5628
	7R0C	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Arrestin2	4.73	2022-09-14	doi.org/10.1126/sciadv.abo7761
	9HAP	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Tolvaptan	-	-	2.5	2025-06-04	doi.org/10.1038/s41467-025-59114-5
	9HB3	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Mambaquaretin-1	-	-	2.5	2025-06-04	doi.org/10.1038/s41467-025-59114-5

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