psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C1	L:L:C6	7.28	No	No	0	0	0
2	L:L:C1	R:R:M311	3.24	No	Yes	0	0	5
3	L:L:C1	R:R:L312	4.76	No	No	0	0	4
4	L:L:Y2	R:R:Q92	11.27	Yes	Yes	1	0	6
5	L:L:Y2	R:R:Q96	6.76	Yes	No	0	0	7
6	L:L:Y2	R:R:F287	4.13	Yes	Yes	1	0	6
7	L:L:Y2	R:R:L312	5.86	Yes	No	0	0	4
8	L:L:Y2	R:R:A314	4	Yes	No	1	0	7
9	L:L:F3	R:R:M120	3.73	Yes	Yes	0	0	5
10	L:L:F3	R:R:V206	6.55	Yes	No	0	0	5
11	L:L:F3	R:R:F287	4.29	Yes	Yes	1	0	6
12	L:L:F3	R:R:F288	5.36	Yes	Yes	1	0	7
13	L:L:F3	R:R:Q291	12.88	Yes	Yes	1	0	6
14	L:L:Q4	R:R:Q291	10.24	Yes	Yes	1	0	6
15	L:L:Q4	R:R:A294	4.55	Yes	No	0	0	4
16	L:L:Q4	R:R:A295	4.55	Yes	No	0	0	5
17	L:L:Q4	R:R:M311	5.44	Yes	Yes	1	0	5
18	L:L:N5	R:R:C195	6.3	No	No	0	0	2
19	L:L:C6	L:L:P7	3.77	No	No	0	0	0
20	L:L:C6	R:R:K100	4.85	No	No	0	0	5
21	L:L:P7	R:R:E303	6.29	No	No	0	0	4
22	L:L:P7	R:R:M311	6.71	No	Yes	0	0	5
23	L:L:R8	R:R:T190	11.64	No	Yes	0	0	4
24	L:L:R8	R:R:W193	7	No	No	0	0	4
25	R:R:D33	R:R:P34	6.44	No	No	0	6	4
26	R:R:D33	R:R:L35	12.21	No	No	4	6	4
27	R:R:D33	R:R:L36	10.86	No	No	4	6	4
28	R:R:L35	R:R:L36	4.15	No	No	4	4	4
29	R:R:A305	R:R:L36	4.73	No	No	0	2	4
30	R:R:E40	R:R:K100	10.8	Yes	No	0	5	5
31	R:R:E40	R:R:L312	5.3	Yes	No	0	5	4
32	R:R:A101	R:R:L41	3.15	No	No	0	4	4
33	R:R:L313	R:R:L43	5.54	No	No	0	7	5
34	R:R:L44	R:R:V93	2.98	No	No	0	7	7
35	R:R:V47	R:R:V93	3.21	No	No	0	7	7
36	R:R:F48	R:R:V93	10.49	No	No	0	6	7
37	R:R:A89	R:R:V51	3.39	No	No	0	7	7
38	R:R:S318	R:R:V51	4.85	No	No	0	9	7
39	R:R:N55	R:R:S54	4.47	No	No	0	9	8
40	R:R:P322	R:R:S54	3.56	No	No	0	9	8
41	R:R:S54	R:R:W323	4.94	No	No	0	8	6
42	R:R:C82	R:R:N55	4.72	No	No	0	9	9
43	R:R:D85	R:R:N55	14.81	No	No	0	9	9
44	R:R:L57	R:R:V58	2.98	Yes	No	0	5	8
45	R:R:L57	R:R:W323	5.69	Yes	No	0	5	6
46	R:R:L336	R:R:L57	4.15	No	Yes	0	6	5
47	R:R:C82	R:R:V58	3.42	No	No	0	9	8
48	R:R:A61	R:R:L336	3.15	No	No	0	7	6
49	R:R:G79	R:R:L62	3.42	No	No	0	5	7
50	R:R:R64	R:R:R67	4.26	No	No	0	6	6
51	R:R:E335	R:R:R64	9.3	No	No	0	6	6
52	R:R:L339	R:R:R64	9.72	No	No	0	4	6
53	R:R:H75	R:R:R65	5.64	Yes	Yes	5	9	5
54	R:R:R65	R:R:S331	6.59	Yes	No	5	5	7
55	R:R:E335	R:R:R65	3.49	No	Yes	0	6	5
56	R:R:R67	R:R:R68	4.26	No	No	0	6	6
57	R:R:E335	R:R:R68	4.65	No	No	0	6	6
58	R:R:A72	R:R:H75	4.39	No	Yes	0	7	9
59	R:R:H75	R:R:I74	5.3	Yes	No	0	9	8
60	R:R:H75	R:R:S331	5.58	Yes	No	5	9	7
61	R:R:D136	R:R:F77	11.94	No	No	0	9	8
62	R:R:H80	R:R:N157	3.83	No	No	3	9	4
63	R:R:H80	R:R:V160	11.07	No	Yes	3	9	7
64	R:R:L81	R:R:N321	8.24	No	No	0	9	9
65	R:R:A84	R:R:M129	3.22	No	Yes	3	8	8
66	R:R:A84	R:R:W164	3.89	No	Yes	3	8	9
67	R:R:D85	R:R:S318	10.31	No	No	0	9	9
68	R:R:D85	R:R:N321	4.04	No	No	0	9	9
69	R:R:Q92	R:R:V88	4.3	Yes	Yes	1	6	7
70	R:R:G122	R:R:V88	3.68	No	Yes	0	8	7
71	R:R:S315	R:R:V88	3.23	No	Yes	1	7	7
72	R:R:S318	R:R:V88	3.23	No	Yes	0	9	7
73	R:R:F91	R:R:L118	6.09	No	No	0	4	5
74	R:R:M123	R:R:Q92	4.08	No	Yes	0	7	6
75	R:R:Q92	R:R:S315	5.78	Yes	No	1	6	7
76	R:R:L94	R:R:P95	3.28	No	No	0	8	5
77	R:R:P95	R:R:V115	3.53	No	No	0	5	5
78	R:R:Q96	R:R:W99	3.29	No	Yes	0	7	5
79	R:R:Q119	R:R:Q96	8.96	No	No	0	7	7
80	R:R:F105	R:R:W99	3.01	Yes	Yes	2	8	5
81	R:R:K116	R:R:W99	5.8	Yes	Yes	2	6	5
82	R:R:T190	R:R:W99	3.64	Yes	Yes	0	4	5
83	R:R:D191	R:R:W99	5.58	Yes	Yes	2	4	5
84	R:R:R106	R:R:T102	12.94	No	No	0	3	5
85	R:R:R104	R:R:R106	4.26	No	No	0	4	3
86	R:R:F105	R:R:G107	3.01	Yes	No	0	8	6
87	R:R:F105	R:R:R181	7.48	Yes	No	2	8	1
88	R:R:D191	R:R:F105	23.88	Yes	Yes	2	4	8
89	R:R:G107	R:R:P108	4.06	No	No	0	6	8
90	R:R:L111	R:R:P108	9.85	No	No	0	5	8
91	R:R:C112	R:R:F178	4.19	No	Yes	2	9	6
92	R:R:C112	R:R:D191	9.34	No	Yes	2	9	4
93	R:R:C112	R:R:C192	5.46	No	No	2	9	9
94	R:R:L175	R:R:R113	3.64	No	No	0	4	7
95	R:R:K116	R:R:Q119	6.78	Yes	No	0	6	7
96	R:R:K116	R:R:Q174	5.42	Yes	Yes	2	6	5
97	R:R:F178	R:R:K116	27.3	Yes	Yes	2	6	6
98	R:R:L168	R:R:Y117	3.52	No	Yes	0	4	5
99	R:R:S171	R:R:Y117	3.82	No	Yes	0	7	5
100	R:R:L172	R:R:Y117	9.38	No	Yes	0	4	5
101	R:R:L175	R:R:Y117	7.03	No	Yes	0	4	5
102	R:R:M120	R:R:Y124	4.79	Yes	Yes	0	5	7
103	R:R:M120	R:R:S171	6.13	Yes	No	0	5	7
104	R:R:M120	R:R:Q174	10.88	Yes	Yes	0	5	5
105	R:R:S167	R:R:V121	3.23	No	No	0	8	5
106	R:R:L168	R:R:V121	2.98	No	No	0	4	5
107	R:R:L170	R:R:Y124	12.89	Yes	Yes	0	4	7
108	R:R:I209	R:R:Y124	4.84	No	Yes	0	5	7
109	R:R:V213	R:R:Y124	3.79	No	Yes	0	5	7
110	R:R:A125	R:R:W164	6.48	No	Yes	0	7	9
111	R:R:A125	R:R:S167	3.42	No	No	0	7	8
112	R:R:S127	R:R:V213	3.23	No	No	0	8	5
113	R:R:P217	R:R:S127	3.56	No	No	1	9	8
114	R:R:S127	R:R:Y280	3.82	No	Yes	1	8	9
115	R:R:F166	R:R:Y128	7.22	No	No	0	3	6
116	R:R:M129	R:R:V160	3.04	Yes	Yes	3	8	7
117	R:R:M129	R:R:W164	3.49	Yes	Yes	3	8	9
118	R:R:M133	R:R:Y325	7.18	No	Yes	0	9	9
119	R:R:I221	R:R:T134	6.08	No	No	0	8	8
120	R:R:C224	R:R:T134	3.38	No	No	0	5	8
121	R:R:Q225	R:R:R137	4.67	No	No	0	9	9
122	R:R:I228	R:R:R137	3.76	No	No	0	8	9
123	R:R:M272	R:R:R137	4.96	No	No	0	8	9
124	R:R:C142	R:R:H138	8.85	No	Yes	0	6	8
125	R:R:C224	R:R:H138	5.9	No	Yes	0	5	8
126	R:R:H138	R:R:L227	6.43	Yes	No	0	8	4
127	R:R:H138	R:R:I228	3.98	Yes	No	0	8	8
128	R:R:C142	R:R:E231	6.08	No	No	0	6	5
129	R:R:L146	R:R:R143	6.07	No	No	0	5	6
130	R:R:M145	R:R:R149	3.72	No	No	0	7	4
131	R:R:L146	R:R:R149	3.64	No	No	0	5	4
132	R:R:N157	R:R:V160	4.43	No	Yes	3	4	7
133	R:R:F166	R:R:L170	4.87	No	Yes	0	3	4
134	R:R:L170	R:R:W208	4.56	Yes	No	0	4	3
135	R:R:F178	R:R:Q174	9.37	Yes	Yes	2	6	5
136	R:R:Q174	R:R:Y205	6.76	Yes	No	0	5	7
137	R:R:I177	R:R:Y205	8.46	No	No	0	5	7
138	R:R:C192	R:R:F178	5.59	No	Yes	2	9	6
139	R:R:C195	R:R:F178	6.98	No	Yes	0	2	6
140	R:R:N182	R:R:Q180	5.28	No	No	0	3	4
141	R:R:D191	R:R:R181	4.76	Yes	No	2	4	1
142	R:R:T190	R:R:V189	3.17	Yes	No	0	4	3
143	R:R:C192	R:R:D191	3.11	No	Yes	2	9	4
144	R:R:A194	R:R:W193	6.48	No	No	0	5	4
145	R:R:A197	R:R:E198	6.03	No	No	0	5	4
146	R:R:E198	R:R:P199	3.14	No	No	0	4	3
147	R:R:R203	R:R:W200	16.99	No	No	0	4	1
148	R:R:T204	R:R:W200	4.85	No	No	0	3	1
149	R:R:R203	R:R:W296	6	No	No	0	4	4
150	R:R:I209	R:R:Y205	13.3	No	No	0	5	7
151	R:R:A295	R:R:V206	5.09	No	No	0	5	5
152	R:R:I209	R:R:W208	4.7	No	No	0	5	3
153	R:R:M212	R:R:W208	8.14	No	No	0	3	3
154	R:R:A210	R:R:F288	4.16	No	Yes	0	5	7
155	R:R:L211	R:R:V215	2.98	No	No	0	5	4
156	R:R:F288	R:R:V213	3.93	Yes	No	0	7	5
157	R:R:F214	R:R:W284	7.02	No	Yes	0	8	8
158	R:R:P217	R:R:Y280	5.56	No	Yes	1	9	9
159	R:R:T218	R:R:Y280	3.75	No	Yes	0	6	9
160	R:R:Q225	R:R:T273	9.92	No	No	0	9	8
161	R:R:P238	R:R:V237	5.3	No	No	0	4	4
162	R:R:G239	R:R:P240	4.06	No	No	0	5	4
163	R:R:L274	R:R:V270	2.98	No	No	0	5	6
164	R:R:F328	R:R:R271	3.21	Yes	No	0	7	7
165	R:R:F328	R:R:M272	13.68	Yes	No	0	7	8
166	R:R:L274	R:R:T273	4.42	No	No	0	5	8
167	R:R:I324	R:R:V275	4.61	No	No	0	8	6
168	R:R:F328	R:R:V275	5.24	Yes	No	0	7	6
169	R:R:I276	R:R:Y325	8.46	No	Yes	0	8	9
170	R:R:T320	R:R:V279	3.17	No	No	0	6	6
171	R:R:I324	R:R:V279	4.61	No	No	0	8	6
172	R:R:W284	R:R:Y280	12.54	Yes	Yes	1	8	9
173	R:R:C283	R:R:N317	6.3	No	No	0	8	9
174	R:R:C283	R:R:T320	3.38	No	No	0	8	6
175	R:R:F287	R:R:W284	3.01	Yes	Yes	1	6	8
176	R:R:F288	R:R:W284	8.02	Yes	Yes	1	7	8
177	R:R:N317	R:R:W284	11.3	No	Yes	0	9	8
178	R:R:A285	R:R:P286	3.74	No	No	0	6	9
179	R:R:F287	R:R:F288	7.5	Yes	Yes	1	6	7
180	R:R:F287	R:R:Q291	12.88	Yes	Yes	1	6	6
181	R:R:A314	R:R:F287	8.32	No	Yes	1	7	6
182	R:R:L310	R:R:V290	4.47	No	No	0	5	5
183	R:R:M311	R:R:V290	4.56	Yes	No	0	5	5
184	R:R:M311	R:R:Q291	8.16	Yes	Yes	1	5	6
185	R:R:D297	R:R:W293	7.82	No	No	6	3	5
186	R:R:P301	R:R:W293	27.02	No	No	6	4	5
187	R:R:F307	R:R:W293	6.01	No	No	0	5	5
188	R:R:D297	R:R:P298	4.83	No	No	0	3	3
189	R:R:D297	R:R:P301	3.22	No	No	6	3	4
190	R:R:A300	R:R:E303	4.53	No	No	0	1	4
191	R:R:L302	R:R:P306	6.57	No	No	0	3	4
192	R:R:F307	R:R:L302	12.18	No	No	0	5	3
193	R:R:N321	R:R:P322	9.77	No	No	0	9	9
194	R:R:I324	R:R:Y325	3.63	No	Yes	0	8	9
195	R:R:S329	R:R:V332	3.23	No	No	0	8	8
196	R:R:L219	R:R:T218	2.95	No	No	0	3	6
197	R:R:I130	R:R:I221	2.94	No	No	0	8	8
198	R:R:I141	R:R:I228	2.94	No	No	0	8	8
199	R:R:P159	R:R:R158	2.88	No	No	0	6	3
200	R:R:Q119	R:R:V115	2.87	No	No	0	7	5
201	R:R:E40	R:R:V308	2.85	Yes	No	0	5	4
202	R:R:L41	R:R:L97	2.77	No	No	0	4	6
203	R:R:L309	R:R:L43	2.77	No	No	0	4	5
204	R:R:A89	R:R:F48	2.77	No	No	0	7	6
205	R:R:H75	R:R:V332	2.77	Yes	No	0	9	8
206	R:R:H80	R:R:V76	2.77	No	No	0	9	4
207	R:R:A132	R:R:F77	2.77	No	No	0	7	8
208	R:R:L86	R:R:L90	2.77	No	No	0	7	5
209	R:R:A147	R:R:Y148	2.67	No	No	0	6	6
210	R:R:E40	R:R:L41	2.65	Yes	No	0	5	4
211	R:R:F229	R:R:V266	2.62	No	Yes	0	5	7
212	R:R:F229	R:R:V270	2.62	No	No	0	5	6
213	R:R:F77	R:R:M133	2.49	No	No	0	8	9
214	R:R:V76	R:R:W71	2.45	No	No	0	4	7
215	R:R:F48	R:R:L90	2.44	No	No	0	6	5
216	R:R:F91	R:R:L90	2.44	No	No	0	4	5
217	R:R:L146	R:R:R139	2.43	No	No	0	5	5
218	R:R:T207	R:R:W296	2.43	No	No	0	5	4
219	R:R:L227	R:R:R230	2.43	No	No	0	4	4
220	R:R:I78	R:R:Y325	2.42	No	Yes	0	8	9
221	L:L:Q4	R:R:R202	2.34	Yes	No	0	0	4
222	R:R:H75	R:R:W71	2.12	Yes	No	0	9	7
223	R:R:G304	R:R:P306	2.03	No	No	0	4	4
224	R:R:C82	R:R:G79	1.96	No	No	0	9	5
225	R:R:A72	R:R:P73	1.87	No	No	0	7	7
226	R:R:A216	R:R:P217	1.87	No	No	0	5	9
227	R:R:A300	R:R:P301	1.87	No	No	0	1	4
228	R:R:A305	R:R:P306	1.87	No	No	0	2	4
229	L:L:G9	R:R:V308	1.84	No	No	0	0	4
230	R:R:A179	R:R:C195	1.81	No	No	0	4	2
231	R:R:C319	R:R:V51	1.71	No	No	0	7	7
232	R:R:G79	R:R:L59	1.71	No	No	0	5	7
233	R:R:G220	R:R:L131	1.71	No	No	0	6	7
234	R:R:G220	R:R:L219	1.71	No	No	0	6	3
235	R:R:A326	R:R:V332	1.7	No	No	0	7	8
236	R:R:I177	R:R:P173	1.69	No	No	0	5	8
237	R:R:E198	R:R:G201	1.64	No	No	0	4	3
238	R:R:L310	R:R:P286	1.64	No	No	0	5	9
239	R:R:S333	R:R:S334	1.63	No	No	0	8	5
240	R:R:S126	R:R:V88	1.62	No	Yes	0	9	7
241	R:R:A163	R:R:M129	1.61	No	Yes	0	7	8
242	R:R:V278	R:R:V279	1.6	No	No	0	4	6
243	R:R:C224	R:R:L135	1.59	No	No	0	5	6
244	R:R:T218	R:R:V281	1.59	No	No	0	6	5
245	R:R:C341	R:R:L340	1.59	No	No	0	3	7
246	R:R:T269	R:R:T273	1.57	No	No	0	7	8
247	R:R:I46	R:R:S45	1.55	No	No	0	4	5
248	R:R:A37	R:R:D103	1.54	No	No	0	5	5
249	R:R:A110	R:R:D109	1.54	No	No	0	2	4
250	R:R:I221	R:R:V277	1.54	No	No	0	8	8
251	R:R:I232	R:R:V266	1.54	No	Yes	0	9	7
252	R:R:L97	R:R:S45	1.5	No	No	0	6	5
253	R:R:G66	R:R:R65	1.5	No	Yes	0	8	5
254	R:R:L339	R:R:S338	1.5	No	No	0	4	5
255	R:R:L53	R:R:V49	1.49	No	No	0	4	5
256	R:R:L161	R:R:V160	1.49	No	Yes	0	2	7
257	R:R:L292	R:R:V206	1.49	No	No	0	5	5
258	R:R:L236	R:R:V266	1.49	No	Yes	0	4	7
259	R:R:L292	R:R:T207	1.47	No	No	0	5	5
260	R:R:P144	R:R:R143	1.44	No	No	0	9	6
261	R:R:E231	R:R:S235	1.44	No	No	0	5	6
262	R:R:L211	R:R:M212	1.41	No	No	0	5	3
263	R:R:L53	R:R:L57	1.38	No	Yes	0	4	5
264	R:R:L169	R:R:L170	1.38	No	Yes	0	4	4
265	R:R:H233	R:R:V266	1.38	No	Yes	0	4	7
266	R:R:A267	R:R:R271	1.38	No	No	0	6	7
267	R:R:L309	R:R:L310	1.38	No	No	0	4	5
268	R:R:L313	R:R:L316	1.38	No	No	0	7	6
269	R:R:P199	R:R:W200	1.35	No	No	0	3	1
270	R:R:F328	R:R:S327	1.32	Yes	No	0	7	5
271	R:R:R158	R:R:V162	1.31	No	No	0	3	3
272	R:R:A87	R:R:W164	1.3	No	Yes	0	6	9
273	R:R:R104	R:R:T190	1.29	No	Yes	0	4	4
274	R:R:L340	R:R:R337	1.21	No	No	0	7	5
275	R:R:D109	R:R:R113	1.19	No	No	0	4	7
276	R:R:L83	R:R:W164	1.14	No	Yes	0	6	9
277	R:R:H138	R:R:R143	1.13	Yes	No	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y2	6.404	5	1	0
2	L:L:F3	6.562	5	1	0
3	L:L:Q4	5.424	5	1	0
4	R:R:E40	5.4	4	0	5
5	R:R:L57	3.55	4	0	5
6	R:R:R65	4.305	4	5	5
7	R:R:H75	4.3	6	5	9
8	R:R:V88	3.212	5	1	7
9	R:R:Q92	6.3575	4	1	6
10	R:R:W99	4.264	5	2	5
11	R:R:F105	9.345	4	2	8
12	R:R:K116	11.325	4	2	6
13	R:R:Y117	5.9375	4	0	5
14	R:R:M120	6.3825	4	0	5
15	R:R:Y124	6.5775	4	0	7
16	R:R:M129	2.84	4	3	8
17	R:R:H138	5.258	5	0	8
18	R:R:V160	5.0075	4	3	7
19	R:R:W164	3.26	5	3	9
20	R:R:L170	5.925	4	0	4
21	R:R:Q174	8.1075	4	2	5
22	R:R:F178	10.686	5	2	6
23	R:R:T190	4.935	4	0	4
24	R:R:D191	9.334	5	2	4
25	R:R:V266	1.7575	4	0	7
26	R:R:Y280	6.4175	4	1	9
27	R:R:W284	8.378	5	1	8
28	R:R:F287	6.68833	6	1	6
29	R:R:F288	5.794	5	1	7
30	R:R:Q291	11.04	4	1	6
31	R:R:M311	5.622	5	1	5
32	R:R:Y325	5.4225	4	0	9
33	R:R:F328	5.8625	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C1	R:R:M311	15.6702	3.24	No	Yes	0	0	5
2	R:R:M311	R:R:Q291	43.115	8.16	Yes	Yes	1	5	6
3	R:R:F287	R:R:Q291	29.7264	12.88	Yes	Yes	1	6	6
4	L:L:C1	R:R:L312	21.8106	4.76	No	No	0	0	4
5	L:L:Y2	R:R:L312	37.7008	5.86	Yes	No	0	0	4
6	L:L:F3	R:R:Q291	19.9178	12.88	Yes	Yes	1	0	6
7	L:L:F3	R:R:M120	92.8472	3.73	Yes	Yes	0	0	5
8	L:L:F3	R:R:V206	28.039	6.55	Yes	No	0	0	5
9	L:L:F3	R:R:F288	29.9098	5.36	Yes	Yes	1	0	7
10	L:L:Y2	R:R:F287	85.2689	4.13	Yes	Yes	1	0	6
11	R:R:M120	R:R:Q174	30.0932	10.88	Yes	Yes	0	5	5
12	R:R:F178	R:R:Q174	12.1121	9.37	Yes	Yes	2	6	5
13	L:L:Y2	R:R:Q96	40.8114	6.76	Yes	No	0	0	7
14	R:R:Q96	R:R:W99	30.46	3.29	No	Yes	0	7	5
15	R:R:K116	R:R:W99	13.4253	5.8	Yes	Yes	2	6	5
16	R:R:Q119	R:R:Q96	10.5495	8.96	No	No	0	7	7
17	L:L:C1	L:L:C6	10.4908	7.28	No	No	0	0	0
18	L:L:C6	L:L:P7	10.6082	3.77	No	No	0	0	0
19	L:L:P7	R:R:M311	37.0259	6.71	No	Yes	0	0	5
20	L:L:P7	R:R:E303	41.2589	6.29	No	No	0	0	4
21	R:R:T190	R:R:W99	17.4822	3.64	Yes	Yes	0	4	5
22	R:R:A300	R:R:E303	38.6105	4.53	No	No	0	1	4
23	R:R:A300	R:R:P301	35.9475	1.87	No	No	0	1	4
24	R:R:P301	R:R:W293	27.7236	27.02	No	No	6	4	5
25	R:R:F307	R:R:W293	25.1486	6.01	No	No	0	5	5
26	R:R:F307	R:R:L302	22.4121	12.18	No	No	0	5	3
27	R:R:L302	R:R:P306	19.6611	6.57	No	No	0	3	4
28	R:R:A305	R:R:P306	14.1149	1.87	No	No	0	2	4
29	R:R:A305	R:R:L36	11.3198	4.73	No	No	0	2	4
30	R:R:E40	R:R:L312	16.4478	5.3	Yes	No	0	5	4
31	R:R:M311	R:R:V290	18.7734	4.56	Yes	No	0	5	5
32	R:R:L310	R:R:V290	16.4771	4.47	No	No	0	5	5
33	L:L:Y2	R:R:Q92	81.3	11.27	Yes	Yes	1	0	6
34	R:R:Q92	R:R:V88	75.8052	4.3	Yes	Yes	1	6	7
35	R:R:S318	R:R:V88	70.6404	3.23	No	Yes	0	9	7
36	R:R:S318	R:R:V51	24.7671	4.85	No	No	0	9	7
37	R:R:A89	R:R:V51	20.3947	3.39	No	No	0	7	7
38	R:R:A89	R:R:F48	18.1865	2.77	No	No	0	7	6
39	R:R:D85	R:R:S318	47.5754	10.31	No	No	0	9	9
40	R:R:D85	R:R:N55	39.1094	14.81	No	No	0	9	9
41	R:R:N55	R:R:S54	15.3107	4.47	No	No	0	9	8
42	R:R:S54	R:R:W323	13.2345	4.94	No	No	0	8	6
43	R:R:C82	R:R:N55	21.9353	4.72	No	No	0	9	9
44	R:R:L57	R:R:W323	11.0557	5.69	Yes	No	0	5	6
45	R:R:C82	R:R:V58	13.2492	3.42	No	No	0	9	8
46	R:R:L57	R:R:V58	11.063	2.98	Yes	No	0	5	8
47	R:R:M120	R:R:S171	82.4518	6.13	Yes	No	0	5	7
48	R:R:S171	R:R:Y117	80.6764	3.82	No	Yes	0	7	5
49	R:R:L168	R:R:Y117	69.7161	3.52	No	Yes	0	4	5
50	R:R:L168	R:R:V121	67.838	2.98	No	No	0	4	5
51	R:R:S167	R:R:V121	65.9453	3.23	No	No	0	8	5
52	R:R:A125	R:R:S167	64.0379	3.42	No	No	0	7	8
53	R:R:A125	R:R:W164	62.1158	6.48	No	Yes	0	7	9
54	R:R:M129	R:R:W164	54.0973	3.49	Yes	Yes	3	8	9
55	R:R:M129	R:R:V160	50.2751	3.04	Yes	Yes	3	8	7
56	R:R:H80	R:R:V160	44.01	11.07	No	Yes	3	9	7
57	R:R:H80	R:R:V76	42.0879	2.77	No	No	0	9	4
58	R:R:V76	R:R:W71	40.0044	2.45	No	No	0	4	7
59	R:R:H75	R:R:W71	37.9062	2.12	Yes	No	0	9	7
60	R:R:H75	R:R:R65	20.5267	5.64	Yes	Yes	5	9	5
61	R:R:E335	R:R:R65	16.1177	3.49	No	Yes	0	6	5
62	R:R:F287	R:R:W284	77.7713	3.01	Yes	Yes	1	6	8
63	R:R:N317	R:R:W284	100	11.3	No	Yes	0	9	8
64	R:R:C283	R:R:N317	98.3493	6.3	No	No	0	8	9
65	R:R:C283	R:R:T320	96.684	3.38	No	No	0	8	6
66	R:R:T320	R:R:V279	95.004	3.17	No	No	0	6	6
67	R:R:I324	R:R:V279	91.578	4.61	No	No	0	8	6
68	R:R:I324	R:R:Y325	16.2351	3.63	No	Yes	0	8	9
69	R:R:F105	R:R:W99	10.8576	3.01	Yes	Yes	2	8	5
70	R:R:M120	R:R:Y124	19.6977	4.79	Yes	Yes	0	5	7
71	R:R:L170	R:R:Y124	16.3671	12.89	Yes	Yes	0	4	7
72	R:R:I209	R:R:Y124	10.997	4.84	No	Yes	0	5	7
73	R:R:F288	R:R:V213	15.0539	3.93	Yes	No	0	7	5
74	R:R:W284	R:R:Y280	16.7486	12.54	Yes	Yes	1	8	9
75	R:R:I324	R:R:V275	77.3604	4.61	No	No	0	8	6
76	R:R:F328	R:R:V275	75.5264	5.24	Yes	No	0	7	6
77	R:R:F328	R:R:M272	67.9921	13.68	Yes	No	0	7	8
78	R:R:M272	R:R:R137	66.07	4.96	No	No	0	8	9
79	R:R:I228	R:R:R137	44.2961	3.76	No	No	0	8	9
80	R:R:H138	R:R:I228	40.2465	3.98	Yes	No	0	8	8
81	R:R:C224	R:R:H138	13.9902	5.9	No	Yes	0	5	8
82	R:R:Q225	R:R:R137	22.867	4.67	No	No	0	9	9
83	R:R:H138	R:R:R143	13.8361	1.13	Yes	No	0	8	6
84	R:R:L292	R:R:V206	26.183	1.49	No	No	0	5	5
85	R:R:L292	R:R:T207	23.63	1.47	No	No	0	5	5
86	R:R:T207	R:R:W296	21.0623	2.43	No	No	0	5	4
87	R:R:R203	R:R:W296	18.4799	6	No	No	0	4	4
88	R:R:R203	R:R:W200	15.8829	16.99	No	No	0	4	1
89	R:R:P199	R:R:W200	10.6449	1.35	No	No	0	3	1
90	R:R:M212	R:R:W208	12.3395	8.14	No	No	0	3	3
91	R:R:T218	R:R:Y280	13.2712	3.75	No	Yes	0	6	9
92	R:R:Q225	R:R:T273	20.6441	9.92	No	No	0	9	8
93	R:R:L274	R:R:T273	16.125	4.42	No	No	0	5	8
94	R:R:L274	R:R:V270	13.8434	2.98	No	No	0	5	6
95	R:R:F229	R:R:V270	11.5472	2.62	No	No	0	5	6
96	R:R:K116	R:R:Q174	15.7068	5.42	Yes	Yes	2	6	5
97	L:L:F3	R:R:F287	57.9561	4.29	Yes	Yes	1	0	6
98	R:R:V213	R:R:Y124	17.3722	3.79	No	Yes	0	5	7
99	R:R:F288	R:R:W284	35.3679	8.02	Yes	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C1	R:R:M311	3.24	0	No	Yes	0	5	0	1
L:L:C1	R:R:L312	4.76	0	No	No	0	4	0	1
L:L:Y2	R:R:Q92	11.27	1	Yes	Yes	0	6	0	1
L:L:Y2	R:R:Q96	6.76	1	Yes	No	0	7	0	1
L:L:Y2	R:R:F287	4.13	1	Yes	Yes	0	6	0	1
L:L:Y2	R:R:L312	5.86	1	Yes	No	0	4	0	1
L:L:Y2	R:R:A314	4	1	Yes	No	0	7	0	1
L:L:F3	R:R:M120	3.73	1	Yes	Yes	0	5	0	1
L:L:F3	R:R:V206	6.55	1	Yes	No	0	5	0	1
L:L:F3	R:R:F287	4.29	1	Yes	Yes	0	6	0	1
L:L:F3	R:R:F288	5.36	1	Yes	Yes	0	7	0	1
L:L:F3	R:R:Q291	12.88	1	Yes	Yes	0	6	0	1
L:L:Q4	R:R:Q291	10.24	1	Yes	Yes	0	6	0	1
L:L:Q4	R:R:A294	4.55	1	Yes	No	0	4	0	1
L:L:Q4	R:R:A295	4.55	1	Yes	No	0	5	0	1
L:L:Q4	R:R:M311	5.44	1	Yes	Yes	0	5	0	1
L:L:N5	R:R:C195	6.3	0	No	No	0	2	0	1
L:L:C6	R:R:K100	4.85	0	No	No	0	5	0	1
L:L:P7	R:R:E303	6.29	0	No	No	0	4	0	1
L:L:P7	R:R:M311	6.71	0	No	Yes	0	5	0	1
L:L:R8	R:R:T190	11.64	0	No	Yes	0	4	0	1
L:L:R8	R:R:W193	7	0	No	No	0	4	0	1
R:R:E40	R:R:K100	10.8	0	Yes	No	5	5	2	1
R:R:E40	R:R:L312	5.3	0	Yes	No	5	4	2	1
R:R:Q92	R:R:V88	4.3	1	Yes	Yes	6	7	1	2
R:R:S315	R:R:V88	3.23	1	No	Yes	7	7	2	2
R:R:M123	R:R:Q92	4.08	0	No	Yes	7	6	2	1
R:R:Q92	R:R:S315	5.78	1	Yes	No	6	7	1	2
R:R:Q96	R:R:W99	3.29	0	No	Yes	7	5	1	2
R:R:Q119	R:R:Q96	8.96	0	No	No	7	7	2	1
R:R:T190	R:R:W99	3.64	0	Yes	Yes	4	5	1	2
R:R:M120	R:R:Y124	4.79	0	Yes	Yes	5	7	1	2
R:R:M120	R:R:S171	6.13	0	Yes	No	5	7	1	2
R:R:M120	R:R:Q174	10.88	0	Yes	Yes	5	5	1	2
R:R:V213	R:R:Y124	3.79	0	No	Yes	5	7	2	2
R:R:F178	R:R:Q174	9.37	2	Yes	Yes	6	5	2	2
R:R:C195	R:R:F178	6.98	0	No	Yes	2	6	1	2
R:R:T190	R:R:V189	3.17	0	Yes	No	4	3	1	2
R:R:A194	R:R:W193	6.48	0	No	No	5	4	2	1
R:R:A295	R:R:V206	5.09	0	No	No	5	5	1	1
R:R:A210	R:R:F288	4.16	0	No	Yes	5	7	2	1
R:R:F288	R:R:V213	3.93	1	Yes	No	7	5	1	2
R:R:F287	R:R:W284	3.01	1	Yes	Yes	6	8	1	2
R:R:F288	R:R:W284	8.02	1	Yes	Yes	7	8	1	2
R:R:F287	R:R:F288	7.5	1	Yes	Yes	6	7	1	1
R:R:F287	R:R:Q291	12.88	1	Yes	Yes	6	6	1	1
R:R:A314	R:R:F287	8.32	1	No	Yes	7	6	1	1
R:R:M311	R:R:V290	4.56	1	Yes	No	5	5	1	2
R:R:M311	R:R:Q291	8.16	1	Yes	Yes	5	6	1	1
R:R:A300	R:R:E303	4.53	0	No	No	1	4	2	1
R:R:E40	R:R:V308	2.85	0	Yes	No	5	4	2	1
L:L:Q4	R:R:R202	2.34	1	Yes	No	0	4	0	1
L:L:G9	R:R:V308	1.84	0	No	No	0	4	0	1
R:R:A179	R:R:C195	1.81	0	No	No	4	2	2	1
R:R:L292	R:R:V206	1.49	0	No	No	5	5	2	1
R:R:R104	R:R:T190	1.29	0	No	Yes	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7KH0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	255
Number of Links	277
Number of Hubs	33
Number of Links mediated by Hubs	119
Number of Communities	6
Number of Nodes involved in Communities	39
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	100
Number Of Links MetaPath	99
Number of Shortest Paths	40366
Length Of Smallest Path	3
Average Path Length	15.2845
Length of Longest Path	38
Minimum Path Strength	1.22
Average Path Strength	5.62226
Maximum Path Strength	17.14
Minimum Path Correlation	0.7
Average Path Correlation	0.937624
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.85714
Average % Of Corr. Nodes	53.5699
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.9343
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	AVP
UniProt	P01185
Sequence	>7KH0_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30518
Sequence	>7KH0_nogp_Chain_R R D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G H W A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D R F R G P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R P M L A Y R N R P V L V A W A F S L L L S L P Q L F I F A Q R N V T D C W A C F A E P W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D P E A P L E G A P F V L L M L L A S L N S C T N P W I Y A S F S S S V S S E L R S L L C C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	doi.org/10.1126/science.1215904
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	doi.org/10.1126/science.1215904
	7KH0	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	chim(NtGi1-Gs)/β1/γ2	2.8	2021-05-26	doi.org/10.1038/s41422-021-00483-z
	7KH0 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		2.8	2021-05-26	doi.org/10.1038/s41422-021-00483-z
	7BB6	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Gs/β1/γ2	4.2	2021-06-02	doi.org/10.1126/sciadv.abg5628
	7BB6 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		4.2	2021-06-02	doi.org/10.1126/sciadv.abg5628
	7BB7	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Gs/β1/γ2	4.4	2021-06-02	doi.org/10.1126/sciadv.abg5628
	7BB7 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		4.4	2021-06-02	doi.org/10.1126/sciadv.abg5628
	7DW9	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	chim(NtGi1-Gs)/β1/γ2	2.6	2021-07-21	doi.org/10.1038/s41422-021-00480-2
	7DW9 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		2.6	2021-07-21	doi.org/10.1038/s41422-021-00480-2
	7R0C	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Arrestin2	4.73	2022-09-14	doi.org/10.1126/sciadv.abo7761
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9HAP	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Tolvaptan	-	-	2.5	2025-06-04	doi.org/10.1038/s41467-025-59114-5
	9HB3	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Mambaquaretin-1	-	-	2.5	2025-06-04	doi.org/10.1038/s41467-025-59114-5
	9V2N	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Macimorelin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.63	2025-07-02	doi.org/10.1038/s41401-025-01606-7
	9V2N (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Macimorelin	-		2.63	2025-07-02	doi.org/10.1038/s41401-025-01606-7
	9U80	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Conivaptan	-	-	2.94	2025-12-10	10.1038/s41467-025-64735-x
	9U80 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Conivaptan	-		2.94	2025-12-10	10.1038/s41467-025-64735-x
	9U81	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Tolvaptan	-	-	3.08	2025-12-10	10.1038/s41467-025-64735-x
	9U81 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	Tolvaptan	-		3.08	2025-12-10	10.1038/s41467-025-64735-x

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