psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C1	L:L:C6	7.28	No	No	0	0	0
2	L:L:C1	R:R:M311	4.86	No	No	0	0	5
3	L:L:Y2	R:R:Q92	12.4	Yes	Yes	1	0	6
4	L:L:Y2	R:R:Q96	9.02	Yes	Yes	1	0	7
5	L:L:Y2	R:R:Q119	4.51	Yes	No	1	0	7
6	L:L:Y2	R:R:M123	3.59	Yes	No	1	0	7
7	L:L:F3	R:R:M120	3.73	Yes	Yes	0	0	5
8	L:L:F3	R:R:V206	6.55	Yes	No	0	0	5
9	L:L:F3	R:R:I209	3.77	Yes	Yes	0	0	5
10	L:L:F3	R:R:F287	4.29	Yes	Yes	2	0	6
11	L:L:F3	R:R:Q291	12.88	Yes	Yes	2	0	6
12	L:L:Q4	R:R:R202	16.35	No	No	0	0	4
13	L:L:Q4	R:R:Q291	6.4	No	Yes	0	0	6
14	L:L:N5	R:R:W193	31.64	No	No	0	0	4
15	L:L:N5	R:R:A194	4.69	No	No	0	0	5
16	L:L:C6	L:L:P7	3.77	No	No	0	0	0
17	L:L:P7	R:R:L302	3.28	No	No	0	0	3
18	L:L:P7	R:R:V308	3.53	No	No	0	0	4
19	L:L:R8	R:R:R32	5.33	Yes	No	0	0	4
20	L:L:R8	R:R:D33	4.76	Yes	Yes	6	0	6
21	L:L:R8	R:R:L36	10.93	Yes	Yes	6	0	4
22	L:L:R8	R:R:E40	4.65	Yes	Yes	0	0	5
23	L:L:G9	R:R:R104	4.5	No	No	0	0	4
24	R:R:A37	R:R:R32	5.53	No	No	0	5	4
25	R:R:D103	R:R:R32	11.91	No	No	0	5	4
26	R:R:D33	R:R:L35	4.07	Yes	No	0	6	4
27	R:R:D33	R:R:L36	5.43	Yes	Yes	6	6	4
28	R:R:L35	R:R:R38	6.07	No	No	0	4	5
29	R:R:E40	R:R:K100	6.75	Yes	No	0	5	5
30	R:R:E40	R:R:V308	5.7	Yes	No	0	5	4
31	R:R:E40	R:R:L312	5.3	Yes	No	0	5	4
32	R:R:L41	R:R:L97	4.15	No	No	0	4	6
33	R:R:L44	R:R:L97	8.3	No	No	0	7	6
34	R:R:L312	R:R:L44	5.54	No	No	7	4	7
35	R:R:L97	R:R:S45	4.5	No	No	0	6	5
36	R:R:F48	R:R:L94	7.31	No	No	0	6	8
37	R:R:A89	R:R:V51	3.39	No	No	0	7	7
38	R:R:S318	R:R:V51	4.85	No	No	0	9	7
39	R:R:C319	R:R:V51	3.42	No	No	0	7	7
40	R:R:S54	R:R:W323	8.65	No	No	0	8	6
41	R:R:D85	R:R:N55	12.12	Yes	No	0	9	9
42	R:R:N55	R:R:P322	8.15	No	No	0	9	9
43	R:R:C82	R:R:V58	3.42	No	No	0	9	8
44	R:R:P322	R:R:V58	3.53	No	No	0	9	8
45	R:R:A326	R:R:V58	3.39	No	No	0	7	8
46	R:R:L62	R:R:W71	6.83	No	Yes	3	7	7
47	R:R:H75	R:R:L62	3.86	Yes	No	3	9	7
48	R:R:E335	R:R:R64	15.12	Yes	No	3	6	6
49	R:R:R64	R:R:S338	3.95	No	No	3	6	5
50	R:R:H70	R:R:R65	4.51	No	Yes	0	8	5
51	R:R:H75	R:R:R65	7.9	Yes	Yes	3	9	5
52	R:R:R65	R:R:S331	6.59	Yes	No	3	5	7
53	R:R:E335	R:R:R65	6.98	Yes	Yes	3	6	5
54	R:R:G66	R:R:W71	5.63	No	Yes	0	8	7
55	R:R:G69	R:R:H70	4.77	No	No	0	5	8
56	R:R:H75	R:R:W71	6.35	Yes	Yes	3	9	7
57	R:R:H155	R:R:W71	9.52	No	Yes	0	4	7
58	R:R:A72	R:R:H75	4.39	No	Yes	0	7	9
59	R:R:H75	R:R:I74	6.63	Yes	No	0	9	8
60	R:R:I74	R:R:I78	4.42	No	No	0	8	8
61	R:R:H75	R:R:S331	6.97	Yes	No	3	9	7
62	R:R:N157	R:R:V76	7.39	No	No	0	4	4
63	R:R:F77	R:R:M133	7.46	Yes	No	0	8	9
64	R:R:D136	R:R:F77	8.36	No	Yes	0	9	8
65	R:R:F77	R:R:N157	3.62	Yes	No	0	8	4
66	R:R:H80	R:R:V160	15.22	No	No	0	9	7
67	R:R:A84	R:R:W164	3.89	No	Yes	0	8	9
68	R:R:D85	R:R:S126	4.42	Yes	No	0	9	9
69	R:R:D85	R:R:S318	10.31	Yes	No	0	9	9
70	R:R:D85	R:R:N321	6.73	Yes	Yes	0	9	9
71	R:R:Q92	R:R:V88	7.16	Yes	Yes	1	6	7
72	R:R:S315	R:R:V88	3.23	No	Yes	1	7	7
73	R:R:S318	R:R:V88	8.08	No	Yes	0	9	7
74	R:R:F91	R:R:L90	4.87	No	No	0	4	5
75	R:R:F91	R:R:L118	3.65	No	No	0	4	5
76	R:R:M123	R:R:Q92	5.44	No	Yes	1	7	6
77	R:R:Q92	R:R:S315	7.22	Yes	No	1	6	7
78	R:R:S315	R:R:V93	3.23	No	No	0	7	7
79	R:R:L94	R:R:P95	3.28	No	No	0	8	5
80	R:R:Q96	R:R:W99	4.38	Yes	Yes	0	7	5
81	R:R:K100	R:R:Q96	5.42	No	Yes	0	5	7
82	R:R:Q119	R:R:Q96	7.68	No	Yes	1	7	7
83	R:R:F105	R:R:W99	8.02	Yes	Yes	0	8	5
84	R:R:D191	R:R:W99	4.47	No	Yes	0	4	5
85	R:R:R106	R:R:T102	5.17	No	No	0	3	5
86	R:R:D191	R:R:R104	19.06	No	No	0	4	4
87	R:R:F105	R:R:L111	6.09	Yes	No	0	8	5
88	R:R:C112	R:R:F105	15.36	No	Yes	1	9	8
89	R:R:F105	R:R:V115	3.93	Yes	No	0	8	5
90	R:R:C192	R:R:F105	4.19	Yes	Yes	1	9	8
91	R:R:G107	R:R:P108	4.06	No	No	0	6	8
92	R:R:L111	R:R:P108	4.93	No	No	0	5	8
93	R:R:C112	R:R:K116	3.23	No	Yes	1	9	6
94	R:R:C112	R:R:C192	7.28	No	Yes	1	9	9
95	R:R:A179	R:R:R113	4.15	No	No	0	4	7
96	R:R:K116	R:R:Q119	5.42	Yes	No	1	6	7
97	R:R:F178	R:R:K116	24.82	Yes	Yes	0	6	6
98	R:R:C192	R:R:K116	3.23	Yes	Yes	1	9	6
99	R:R:L118	R:R:Y117	3.52	No	Yes	0	5	5
100	R:R:V121	R:R:Y117	3.79	No	Yes	4	5	5
101	R:R:S171	R:R:Y117	5.09	No	Yes	4	7	5
102	R:R:L172	R:R:Y117	7.03	No	Yes	0	4	5
103	R:R:L175	R:R:Y117	4.69	No	Yes	0	4	5
104	R:R:M120	R:R:M123	5.78	Yes	No	0	5	7
105	R:R:M120	R:R:Y124	7.18	Yes	Yes	0	5	7
106	R:R:M120	R:R:S171	6.13	Yes	No	0	5	7
107	R:R:M120	R:R:Q174	8.16	Yes	No	0	5	5
108	R:R:S167	R:R:V121	3.23	No	No	4	8	5
109	R:R:S171	R:R:V121	4.85	No	No	4	7	5
110	R:R:Y124	R:R:Y128	4.96	Yes	No	0	7	6
111	R:R:L170	R:R:Y124	10.55	Yes	Yes	0	4	7
112	R:R:I209	R:R:Y124	4.84	Yes	Yes	0	5	7
113	R:R:V213	R:R:Y124	3.79	No	Yes	0	5	7
114	R:R:A125	R:R:W164	3.89	No	Yes	4	7	9
115	R:R:A125	R:R:S167	3.42	No	No	4	7	8
116	R:R:P217	R:R:S127	3.56	No	No	2	9	8
117	R:R:S127	R:R:Y280	3.82	No	Yes	2	8	9
118	R:R:M212	R:R:Y128	3.59	No	No	0	3	6
119	R:R:M129	R:R:V160	4.56	No	No	0	8	7
120	R:R:M129	R:R:W164	6.98	No	Yes	0	8	9
121	R:R:I130	R:R:I221	4.42	No	No	0	8	8
122	R:R:I130	R:R:N321	5.66	No	Yes	0	8	9
123	R:R:I130	R:R:Y325	3.63	No	No	0	8	9
124	R:R:M133	R:R:Y325	8.38	No	No	0	9	9
125	R:R:D136	R:R:R139	5.96	No	Yes	0	9	5
126	R:R:Q225	R:R:R137	3.5	No	No	0	9	9
127	R:R:I228	R:R:R137	3.76	No	No	0	8	9
128	R:R:C142	R:R:H138	10.32	No	Yes	0	6	8
129	R:R:H138	R:R:L227	5.14	Yes	No	0	8	4
130	R:R:H138	R:R:I228	3.98	Yes	No	0	8	8
131	R:R:A140	R:R:R139	4.15	No	Yes	0	8	5
132	R:R:R139	R:R:Y148	6.17	Yes	No	0	5	6
133	R:R:L146	R:R:R143	8.5	No	No	0	5	6
134	R:R:H150	R:R:R158	20.31	No	No	0	5	3
135	R:R:G153	R:R:S152	3.71	No	No	0	4	7
136	R:R:N157	R:R:S152	5.96	No	No	0	4	7
137	R:R:G153	R:R:W156	5.63	No	No	0	4	7
138	R:R:A154	R:R:H155	4.39	No	No	0	4	4
139	R:R:L161	R:R:W156	5.69	No	No	0	2	7
140	R:R:S167	R:R:W164	3.71	No	Yes	4	8	9
141	R:R:L170	R:R:W208	3.42	Yes	No	8	4	3
142	R:R:L170	R:R:M212	4.24	Yes	No	8	4	3
143	R:R:F178	R:R:Q174	7.03	Yes	No	0	6	5
144	R:R:Q174	R:R:Y205	5.64	No	Yes	0	5	7
145	R:R:F178	R:R:I177	7.54	Yes	No	0	6	5
146	R:R:F196	R:R:I177	8.79	Yes	No	0	5	5
147	R:R:A194	R:R:F178	4.16	No	Yes	0	5	6
148	R:R:A179	R:R:R181	6.91	No	No	0	4	1
149	R:R:C195	R:R:R181	9.75	No	No	0	2	1
150	R:R:E184	R:R:N182	10.52	No	No	0	1	3
151	R:R:V183	R:R:W193	15.94	No	No	0	1	4
152	R:R:F196	R:R:R202	6.41	Yes	No	0	5	4
153	R:R:F196	R:R:Y205	4.13	Yes	Yes	0	5	7
154	R:R:R203	R:R:W296	13.99	No	No	0	4	4
155	R:R:I209	R:R:Y205	4.84	Yes	Yes	0	5	7
156	R:R:A295	R:R:V206	5.09	No	No	0	5	5
157	R:R:T207	R:R:W296	4.85	No	No	0	5	4
158	R:R:I209	R:R:W208	4.7	Yes	No	0	5	3
159	R:R:M212	R:R:W208	10.47	No	No	8	3	3
160	R:R:A210	R:R:F288	4.16	No	Yes	0	5	7
161	R:R:A210	R:R:L292	4.73	No	No	0	5	5
162	R:R:F288	R:R:V213	5.24	Yes	No	0	7	5
163	R:R:F214	R:R:V215	3.93	No	No	0	8	4
164	R:R:F214	R:R:W284	4.01	No	Yes	2	8	8
165	R:R:F214	R:R:F288	5.36	No	Yes	2	8	7
166	R:R:P217	R:R:Y280	4.17	No	Yes	2	9	9
167	R:R:T218	R:R:Y280	6.24	No	Yes	0	6	9
168	R:R:M272	R:R:Q225	4.08	No	No	0	8	9
169	R:R:Q225	R:R:T273	5.67	No	No	0	9	8
170	R:R:F229	R:R:H233	4.53	Yes	No	0	5	4
171	R:R:S263	R:R:V266	4.85	No	No	0	4	7
172	R:R:K268	R:R:R271	4.95	No	No	0	8	7
173	R:R:F328	R:R:K268	4.96	No	No	0	7	8
174	R:R:F328	R:R:M272	12.44	No	No	0	7	8
175	R:R:I324	R:R:V275	4.61	No	No	0	8	6
176	R:R:I276	R:R:Y325	6.04	No	No	0	8	9
177	R:R:T320	R:R:V279	4.76	No	No	0	6	6
178	R:R:W284	R:R:Y280	11.58	Yes	Yes	2	8	9
179	R:R:N317	R:R:Y280	4.65	Yes	Yes	2	9	9
180	R:R:C283	R:R:N317	9.45	No	Yes	0	8	9
181	R:R:F288	R:R:W284	6.01	Yes	Yes	2	7	8
182	R:R:N317	R:R:W284	12.43	Yes	Yes	2	9	8
183	R:R:F287	R:R:F288	11.79	Yes	Yes	2	6	7
184	R:R:F287	R:R:Q291	12.88	Yes	Yes	2	6	6
185	R:R:A314	R:R:F287	8.32	No	Yes	0	7	6
186	R:R:F307	R:R:V290	7.87	Yes	No	0	5	5
187	R:R:L310	R:R:V290	5.96	No	No	0	5	5
188	R:R:M311	R:R:Q291	12.23	No	Yes	0	5	6
189	R:R:L292	R:R:W296	3.42	No	No	0	5	4
190	R:R:D297	R:R:W293	8.93	Yes	Yes	5	3	5
191	R:R:A300	R:R:W293	6.48	No	Yes	5	1	5
192	R:R:P301	R:R:W293	6.76	No	Yes	5	4	5
193	R:R:F307	R:R:W293	5.01	Yes	Yes	5	5	5
194	R:R:D297	R:R:P298	6.44	Yes	No	0	3	3
195	R:R:D297	R:R:E299	6.5	Yes	No	0	3	2
196	R:R:A300	R:R:D297	4.63	No	Yes	5	1	3
197	R:R:F307	R:R:P301	5.78	Yes	No	5	5	4
198	R:R:F307	R:R:L302	4.87	Yes	No	0	5	3
199	R:R:E303	R:R:G304	3.27	No	No	0	4	4
200	R:R:F307	R:R:M311	3.73	Yes	No	0	5	5
201	R:R:L313	R:R:L316	6.92	No	No	0	7	6
202	R:R:N317	R:R:N321	12.26	Yes	Yes	0	9	9
203	R:R:N321	R:R:P322	3.26	Yes	No	0	9	9
204	R:R:S329	R:R:S331	4.89	No	No	0	8	7
205	R:R:S329	R:R:V332	6.46	No	No	0	8	8
206	R:R:E335	R:R:S338	4.31	Yes	No	3	6	5
207	R:R:A163	R:R:M129	3.22	No	No	0	7	8
208	R:R:C224	R:R:L135	3.17	No	No	0	5	6
209	R:R:C283	R:R:L316	3.17	No	No	0	8	6
210	R:R:A305	R:R:L36	3.15	No	Yes	0	2	4
211	R:R:A101	R:R:L41	3.15	No	No	0	4	4
212	R:R:E198	R:R:P199	3.14	No	No	0	4	3
213	R:R:I324	R:R:V279	3.07	No	No	0	8	6
214	R:R:C192	R:R:Q180	3.05	Yes	No	0	9	4
215	R:R:I221	R:R:T134	3.04	No	No	0	8	8
216	R:R:C142	R:R:E231	3.04	No	No	0	6	5
217	R:R:A61	R:R:E335	3.02	No	Yes	0	7	6
218	R:R:R181	R:R:W193	3	No	No	0	1	4
219	R:R:L282	R:R:V278	2.98	No	No	0	5	4
220	R:R:C224	R:R:H138	2.95	No	Yes	0	5	8
221	R:R:I228	R:R:I232	2.94	No	No	0	8	9
222	R:R:N182	R:R:T190	2.92	No	No	0	3	4
223	R:R:I276	R:R:M272	2.92	No	No	0	8	8
224	R:R:F77	R:R:P159	2.89	Yes	No	0	8	6
225	R:R:P159	R:R:R158	2.88	No	No	0	6	3
226	R:R:E184	R:R:V189	2.85	No	No	0	1	3
227	R:R:Q180	R:R:T190	2.83	No	No	0	4	4
228	R:R:P173	R:R:Y205	2.78	No	Yes	0	8	7
229	R:R:L43	R:R:L44	2.77	No	No	7	5	7
230	R:R:L309	R:R:L43	2.77	No	No	0	4	5
231	R:R:L312	R:R:L43	2.77	No	No	7	4	5
232	R:R:L131	R:R:L135	2.77	No	No	0	7	6
233	R:R:L169	R:R:L170	2.77	No	Yes	0	4	4
234	R:R:A294	R:R:F307	2.77	No	Yes	0	4	5
235	R:R:L86	R:R:N55	2.75	No	No	0	7	9
236	R:R:L81	R:R:N321	2.75	No	Yes	0	9	9
237	R:R:F166	R:R:V162	2.62	No	No	0	3	3
238	R:R:F229	R:R:V266	2.62	Yes	No	0	5	7
239	R:R:F229	R:R:V270	2.62	Yes	No	0	5	6
240	R:R:D109	R:R:Q180	2.61	No	No	0	4	4
241	R:R:A197	R:R:W200	2.59	No	Yes	0	5	1
242	R:R:F229	R:R:T269	2.59	Yes	No	0	5	7
243	R:R:F328	R:R:I324	2.51	No	No	0	7	8
244	R:R:V76	R:R:W71	2.45	No	Yes	0	4	7
245	R:R:T204	R:R:W200	2.43	No	Yes	0	3	1
246	R:R:L168	R:R:Y117	2.34	No	Yes	0	4	5
247	R:R:H150	R:R:R149	2.26	No	No	0	5	4
248	R:R:R67	R:R:R68	2.13	No	No	0	6	6
249	R:R:G304	R:R:P306	2.03	No	No	0	4	4
250	R:R:A72	R:R:P73	1.87	No	No	0	7	7
251	R:R:A216	R:R:P217	1.87	No	No	0	5	9
252	R:R:A285	R:R:P286	1.87	No	No	0	6	9
253	R:R:A305	R:R:P306	1.87	No	No	0	2	4
254	R:R:G122	R:R:V88	1.84	No	Yes	0	8	7
255	R:R:A50	R:R:C319	1.81	No	No	0	6	7
256	R:R:P95	R:R:V115	1.77	No	No	0	5	5
257	R:R:C319	R:R:V47	1.71	No	No	0	7	7
258	R:R:G56	R:R:L59	1.71	No	No	0	3	7
259	R:R:G79	R:R:L62	1.71	No	No	0	5	7
260	R:R:G220	R:R:L131	1.71	No	No	0	6	7
261	R:R:G220	R:R:L219	1.71	No	No	0	6	3
262	R:R:A265	R:R:S263	1.71	No	No	0	7	4
263	R:R:A222	R:R:V277	1.7	No	No	0	5	8
264	R:R:A285	R:R:V281	1.7	No	No	0	6	5
265	R:R:A265	R:R:I232	1.62	No	No	0	7	9
266	R:R:D33	R:R:P34	1.61	Yes	No	0	6	4
267	R:R:C82	R:R:L59	1.59	No	No	0	9	7
268	R:R:G151	R:R:H150	1.59	No	No	0	6	5
269	R:R:T218	R:R:V277	1.59	No	No	0	6	8
270	R:R:T218	R:R:V281	1.59	No	No	0	6	5
271	R:R:A39	R:R:L36	1.58	No	Yes	0	4	4
272	R:R:A39	R:R:L309	1.58	No	No	0	4	4
273	R:R:A61	R:R:L336	1.58	No	No	0	7	6
274	R:R:A110	R:R:D109	1.54	No	No	0	2	4
275	R:R:K268	R:R:S330	1.53	No	No	0	8	5
276	R:R:F196	R:R:G201	1.51	Yes	No	0	5	3
277	R:R:G69	R:R:R68	1.5	No	No	0	5	6
278	R:R:L274	R:R:V270	1.49	No	No	0	5	6
279	R:R:L289	R:R:V290	1.49	No	No	0	5	5
280	R:R:I141	R:R:I232	1.47	No	No	0	8	9
281	R:R:P144	R:R:R143	1.44	No	No	0	9	6
282	R:R:G201	R:R:W200	1.41	No	Yes	0	3	1
283	R:R:A132	R:R:F77	1.39	No	Yes	0	7	8
284	R:R:L59	R:R:L83	1.38	No	No	0	7	6
285	R:R:A267	R:R:R271	1.38	No	No	0	6	7
286	R:R:P199	R:R:W200	1.35	No	Yes	0	3	1
287	R:R:R158	R:R:V162	1.31	No	No	0	3	3
288	R:R:R230	R:R:V226	1.31	No	No	0	4	3
289	R:R:T102	R:R:W99	1.21	No	Yes	0	5	5
290	R:R:R139	R:R:R143	1.07	Yes	No	0	5	6
291	R:R:F229	R:R:R230	1.07	Yes	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y2	7.38	4	1	0
2	L:L:F3	6.244	5	2	0
3	L:L:R8	6.4175	4	6	0
4	R:R:D33	3.9675	4	6	6
5	R:R:L36	5.2725	4	6	4
6	R:R:E40	5.6	4	0	5
7	R:R:R65	6.495	4	3	5
8	R:R:W71	6.156	5	3	7
9	R:R:H75	6.01667	6	3	9
10	R:R:F77	4.744	5	0	8
11	R:R:D85	8.395	4	0	9
12	R:R:V88	5.0775	4	1	7
13	R:R:Q92	8.055	4	1	6
14	R:R:Q96	6.625	4	1	7
15	R:R:W99	4.52	4	0	5
16	R:R:F105	7.518	5	1	8
17	R:R:K116	9.175	4	1	6
18	R:R:Y117	4.41	6	4	5
19	R:R:M120	6.196	5	0	5
20	R:R:Y124	6.264	5	0	7
21	R:R:H138	5.5975	4	0	8
22	R:R:R139	4.3375	4	0	5
23	R:R:W164	4.6175	4	4	9
24	R:R:L170	5.245	4	8	4
25	R:R:F178	10.8875	4	0	6
26	R:R:C192	4.4375	4	1	9
27	R:R:F196	5.21	4	0	5
28	R:R:W200	1.945	4	0	1
29	R:R:Y205	4.3475	4	0	7
30	R:R:I209	4.5375	4	0	5
31	R:R:F229	2.686	5	0	5
32	R:R:Y280	6.092	5	2	9
33	R:R:W284	8.5075	4	2	8
34	R:R:F287	9.32	4	2	6
35	R:R:F288	6.512	5	2	7
36	R:R:Q291	11.0975	4	2	6
37	R:R:W293	6.795	4	5	5
38	R:R:D297	6.625	4	5	3
39	R:R:F307	5.005	6	5	5
40	R:R:N317	9.6975	4	2	9
41	R:R:N321	6.132	5	0	9
42	R:R:E335	7.3575	4	3	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M311	R:R:Q291	20.4187	12.23	No	Yes	0	5	6
2	L:L:F3	R:R:M120	28.8768	3.73	Yes	Yes	0	0	5
3	R:R:M120	R:R:M123	32.1599	5.78	Yes	No	0	5	7
4	L:L:Y2	R:R:M123	13.9973	3.59	Yes	No	1	0	7
5	R:R:M123	R:R:Q92	18.3997	5.44	No	Yes	1	7	6
6	R:R:E40	R:R:K100	29.1797	6.75	Yes	No	0	5	5
7	R:R:K100	R:R:Q96	30.176	5.42	No	Yes	0	5	7
8	L:L:Y2	R:R:Q119	11.6183	4.51	Yes	No	1	0	7
9	R:R:F287	R:R:Q291	19.7516	12.88	Yes	Yes	2	6	6
10	R:R:M120	R:R:Q174	30.0443	8.16	Yes	No	0	5	5
11	R:R:F178	R:R:Q174	27.977	7.03	Yes	No	0	6	5
12	R:R:A194	R:R:F178	21.4502	4.16	No	Yes	0	5	6
13	L:L:N5	R:R:A194	18.7991	4.69	No	No	0	0	5
14	L:L:N5	R:R:W193	16.1392	31.64	No	No	0	0	4
15	R:R:F307	R:R:M311	14.5679	3.73	Yes	No	0	5	5
16	L:L:R8	R:R:E40	20.8138	4.65	Yes	Yes	0	0	5
17	R:R:Q96	R:R:W99	16.8986	4.38	Yes	Yes	0	7	5
18	R:R:E40	R:R:L312	11.9914	5.3	Yes	No	0	5	4
19	R:R:F105	R:R:W99	11.3111	8.02	Yes	Yes	0	8	5
20	R:R:Q92	R:R:V88	51.5297	7.16	Yes	Yes	1	6	7
21	R:R:S318	R:R:V88	52.5216	8.08	No	Yes	0	9	7
22	R:R:F287	R:R:F288	49.3263	11.79	Yes	Yes	2	6	7
23	R:R:F288	R:R:W284	73.1203	6.01	Yes	Yes	2	7	8
24	R:R:N317	R:R:W284	59.5312	12.43	Yes	Yes	2	9	8
25	R:R:N317	R:R:N321	66.4487	12.26	Yes	Yes	0	9	9
26	R:R:D85	R:R:N321	49.4535	6.73	Yes	Yes	0	9	9
27	R:R:N321	R:R:P322	11.7324	3.26	Yes	No	0	9	9
28	R:R:P322	R:R:V58	11.7939	3.53	No	No	0	9	8
29	R:R:I130	R:R:N321	100	5.66	No	Yes	0	8	9
30	R:R:I130	R:R:Y325	97.6035	3.63	No	No	0	8	9
31	R:R:M133	R:R:Y325	62.0638	8.38	No	No	0	9	9
32	R:R:F77	R:R:M133	60.927	7.46	Yes	No	0	8	9
33	R:R:F77	R:R:N157	42.0226	3.62	Yes	No	0	8	4
34	R:R:N157	R:R:V76	35.6406	7.39	No	No	0	4	4
35	R:R:V76	R:R:W71	34.3151	2.45	No	Yes	0	4	7
36	R:R:H75	R:R:W71	26.1116	6.35	Yes	Yes	3	9	7
37	R:R:H75	R:R:R65	14.8268	7.9	Yes	Yes	3	9	5
38	R:R:D136	R:R:F77	10.3191	8.36	No	Yes	0	9	8
39	R:R:M120	R:R:S171	36.1103	6.13	Yes	No	0	5	7
40	R:R:S171	R:R:V121	19.1546	4.85	No	No	4	7	5
41	R:R:S167	R:R:V121	17.3068	3.23	No	No	4	8	5
42	R:R:S167	R:R:W164	13.0053	3.71	No	Yes	4	8	9
43	R:R:S171	R:R:Y117	14.8971	5.09	No	Yes	4	7	5
44	R:R:F178	R:R:K116	21.1517	24.82	Yes	Yes	0	6	6
45	R:R:C192	R:R:K116	13.3872	3.23	Yes	Yes	1	9	6
46	R:R:R181	R:R:W193	10.7931	3	No	No	0	1	4
47	R:R:M120	R:R:Y124	25.8526	7.18	Yes	Yes	0	5	7
48	R:R:F288	R:R:V213	31.901	5.24	Yes	No	0	7	5
49	R:R:W284	R:R:Y280	13.8656	11.58	Yes	Yes	2	8	9
50	R:R:I276	R:R:Y325	49.3219	6.04	No	No	0	8	9
51	R:R:I276	R:R:M272	48.2026	2.92	No	No	0	8	8
52	R:R:M272	R:R:Q225	35.386	4.08	No	No	0	8	9
53	R:R:Q225	R:R:R137	32.8315	3.5	No	No	0	9	9
54	R:R:I228	R:R:R137	31.6025	3.76	No	No	0	8	9
55	R:R:H138	R:R:I228	13.475	3.98	Yes	No	0	8	8
56	R:R:F77	R:R:P159	10.3191	2.89	Yes	No	0	8	6
57	R:R:I209	R:R:Y205	11.6227	4.84	Yes	Yes	0	5	7
58	R:R:T218	R:R:Y280	12.5839	6.24	No	Yes	0	6	9
59	R:R:I228	R:R:I232	17.715	2.94	No	No	0	8	9
60	R:R:A265	R:R:I232	14.8268	1.62	No	No	0	7	9
61	R:R:A265	R:R:S263	13.5057	1.71	No	No	0	7	4
62	R:R:S263	R:R:V266	12.0397	4.85	No	No	0	4	7
63	R:R:F229	R:R:V266	10.5649	2.62	Yes	No	0	5	7
64	R:R:F328	R:R:M272	13.453	12.44	No	No	0	7	8
65	R:R:F196	R:R:G201	13.611	1.51	Yes	No	0	5	3
66	R:R:G201	R:R:W200	11.3637	1.41	No	Yes	0	3	1
67	L:L:Y2	R:R:Q96	36.2683	9.02	Yes	Yes	1	0	7
68	L:L:Y2	R:R:Q92	34.6179	12.4	Yes	Yes	1	0	6
69	R:R:K116	R:R:Q119	15.1121	5.42	Yes	No	1	6	7
70	L:L:F3	R:R:F287	30.2023	4.29	Yes	Yes	2	0	6
71	R:R:F196	R:R:Y205	10.1304	4.13	Yes	Yes	0	5	7
72	R:R:D85	R:R:S318	52.2056	10.31	Yes	No	0	9	9
73	R:R:V213	R:R:Y124	31.8	3.79	No	Yes	0	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C1	R:R:M311	4.86	0	No	No	0	5	0	1
L:L:Y2	R:R:Q92	12.4	1	Yes	Yes	0	6	0	1
L:L:Y2	R:R:Q96	9.02	1	Yes	Yes	0	7	0	1
L:L:Y2	R:R:Q119	4.51	1	Yes	No	0	7	0	1
L:L:Y2	R:R:M123	3.59	1	Yes	No	0	7	0	1
L:L:F3	R:R:M120	3.73	2	Yes	Yes	0	5	0	1
L:L:F3	R:R:V206	6.55	2	Yes	No	0	5	0	1
L:L:F3	R:R:I209	3.77	2	Yes	Yes	0	5	0	1
L:L:F3	R:R:F287	4.29	2	Yes	Yes	0	6	0	1
L:L:F3	R:R:Q291	12.88	2	Yes	Yes	0	6	0	1
L:L:Q4	R:R:R202	16.35	0	No	No	0	4	0	1
L:L:Q4	R:R:Q291	6.4	0	No	Yes	0	6	0	1
L:L:N5	R:R:W193	31.64	0	No	No	0	4	0	1
L:L:N5	R:R:A194	4.69	0	No	No	0	5	0	1
L:L:P7	R:R:L302	3.28	0	No	No	0	3	0	1
L:L:P7	R:R:V308	3.53	0	No	No	0	4	0	1
L:L:R8	R:R:R32	5.33	6	Yes	No	0	4	0	1
L:L:R8	R:R:D33	4.76	6	Yes	Yes	0	6	0	1
L:L:R8	R:R:L36	10.93	6	Yes	Yes	0	4	0	1
L:L:R8	R:R:E40	4.65	6	Yes	Yes	0	5	0	1
L:L:G9	R:R:R104	4.5	0	No	No	0	4	0	1
R:R:A37	R:R:R32	5.53	0	No	No	5	4	2	1
R:R:D103	R:R:R32	11.91	0	No	No	5	4	2	1
R:R:D33	R:R:L35	4.07	6	Yes	No	6	4	1	2
R:R:D33	R:R:L36	5.43	6	Yes	Yes	6	4	1	1
R:R:E40	R:R:K100	6.75	0	Yes	No	5	5	1	2
R:R:E40	R:R:V308	5.7	0	Yes	No	5	4	1	1
R:R:E40	R:R:L312	5.3	0	Yes	No	5	4	1	2
R:R:Q92	R:R:V88	7.16	1	Yes	Yes	6	7	1	2
R:R:S315	R:R:V88	3.23	1	No	Yes	7	7	2	2
R:R:M123	R:R:Q92	5.44	1	No	Yes	7	6	1	1
R:R:Q92	R:R:S315	7.22	1	Yes	No	6	7	1	2
R:R:Q96	R:R:W99	4.38	1	Yes	Yes	7	5	1	2
R:R:K100	R:R:Q96	5.42	0	No	Yes	5	7	2	1
R:R:Q119	R:R:Q96	7.68	1	No	Yes	7	7	1	1
R:R:D191	R:R:W99	4.47	0	No	Yes	4	5	2	2
R:R:D191	R:R:R104	19.06	0	No	No	4	4	2	1
R:R:K116	R:R:Q119	5.42	1	Yes	No	6	7	2	1
R:R:F178	R:R:K116	24.82	0	Yes	Yes	6	6	2	2
R:R:M120	R:R:M123	5.78	0	Yes	No	5	7	1	1
R:R:M120	R:R:Y124	7.18	0	Yes	Yes	5	7	1	2
R:R:M120	R:R:S171	6.13	0	Yes	No	5	7	1	2
R:R:M120	R:R:Q174	8.16	0	Yes	No	5	5	1	2
R:R:I209	R:R:Y124	4.84	0	Yes	Yes	5	7	1	2
R:R:F178	R:R:Q174	7.03	0	Yes	No	6	5	2	2
R:R:Q174	R:R:Y205	5.64	0	No	Yes	5	7	2	2
R:R:A194	R:R:F178	4.16	0	No	Yes	5	6	1	2
R:R:V183	R:R:W193	15.94	0	No	No	1	4	2	1
R:R:F196	R:R:R202	6.41	0	Yes	No	5	4	2	1
R:R:F196	R:R:Y205	4.13	0	Yes	Yes	5	7	2	2
R:R:I209	R:R:Y205	4.84	0	Yes	Yes	5	7	1	2
R:R:A295	R:R:V206	5.09	0	No	No	5	5	2	1
R:R:I209	R:R:W208	4.7	0	Yes	No	5	3	1	2
R:R:F287	R:R:F288	11.79	2	Yes	Yes	6	7	1	2
R:R:F287	R:R:Q291	12.88	2	Yes	Yes	6	6	1	1
R:R:A314	R:R:F287	8.32	0	No	Yes	7	6	2	1
R:R:M311	R:R:Q291	12.23	0	No	Yes	5	6	1	1
R:R:F307	R:R:L302	4.87	5	Yes	No	5	3	2	1
R:R:F307	R:R:M311	3.73	5	Yes	No	5	5	2	1
R:R:A305	R:R:L36	3.15	0	No	Yes	2	4	2	1
R:R:R181	R:R:W193	3	0	No	No	1	4	2	1
R:R:D33	R:R:P34	1.61	6	Yes	No	6	4	1	2
R:R:A39	R:R:L36	1.58	0	No	Yes	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7DW9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.23
Number of Linked Nodes	261
Number of Links	291
Number of Hubs	42
Number of Links mediated by Hubs	150
Number of Communities	8
Number of Nodes involved in Communities	49
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	48872
Length Of Smallest Path	3
Average Path Length	13.9335
Length of Longest Path	29
Minimum Path Strength	1.19
Average Path Strength	6.37822
Maximum Path Strength	23.79
Minimum Path Correlation	0.7
Average Path Correlation	0.927434
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	50.133
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.6098
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• regulation of body fluid levels • hemostasis • biological regulation • regulation of biological quality • regulation of tube diameter • multicellular organismal process • regulation of biological process • system process • regulation of tube size • regulation of system process • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • regulation of biosynthetic process • regulation of cellular process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • cellular process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • cellular response to stimulus • response to stimulus • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • response to peptide • response to cytokine • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of systemic arterial blood pressure • endocrine process • regulation of systemic arterial blood pressure by vasopressin • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of cell communication • regulation of signaling • positive regulation of signal transduction • positive regulation of intracellular signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • renal system process • regulation of urine volume • renal water retention • negative regulation of urine volume • developmental process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • telencephalon development • system development • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • positive regulation of systemic arterial blood pressure • positive regulation of blood pressure • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • intracellular membrane-bounded organelle • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle • cytoplasm • organelle membrane • cell periphery • plasma membrane • Golgi apparatus • endomembrane system • endosome • perinuclear region of cytoplasm • endoplasmic reticulum • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D1 dopamine receptor binding • molecular function activator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • regulation of hormone secretion • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • response to hypoxia • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • vasopressin receptor binding • V1B vasopressin receptor binding • molecular transducer activity • signaling receptor activity • neuropeptide activity • signaling receptor activator activity • hormone activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • neurohypophyseal hormone activity • V1A vasopressin receptor binding • catalytic activity, acting on a protein • kinase activity • protein kinase activity • transferase activity • phosphotransferase activity, alcohol group as acceptor • transferase activity, transferring phosphorus-containing groups • regulation of growth • positive regulation of cell growth • regulation of cell growth • cell growth • positive regulation of growth • behavior • locomotory behavior • reproductive process • negative regulation of female receptivity • multicellular organismal reproductive process • female mating behavior • mating behavior • regulation of female receptivity • reproductive behavior • negative regulation of nervous system process • regulation of system process • transmission of nerve impulse • negative regulation of transmission of nerve impulse • negative regulation of cell communication • regulation of nervous system process • regulation of transmission of nerve impulse • negative regulation of cellular process • negative regulation of multicellular organismal process • regulation of tube diameter • regulation of tube size • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • negative regulation of apoptotic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of gene expression • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • response to testosterone • biological process involved in interspecies interaction between organisms • symbiont entry into host cell • viral process • symbiont entry into host • viral life cycle • biological process involved in interaction with host • biological process involved in symbiotic interaction • maternal behavior • parental behavior • fluid transport • water transport • generation of precursor metabolites and energy • positive regulation of cellular pH reduction • intracellular pH reduction • regulation of intracellular pH • cellular homeostasis • regulation of cellular pH reduction • intracellular monoatomic cation homeostasis • regulation of pH • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • regulation of cellular pH • intracellular monoatomic ion homeostasis • response to ethanol • prostaglandin metabolic process • unsaturated fatty acid metabolic process • oxoacid metabolic process • organic acid biosynthetic process • organic acid metabolic process • carboxylic acid biosynthetic process • positive regulation of prostaglandin biosynthetic process • prostaglandin biosynthetic process • regulation of ketone metabolic process • regulation of fatty acid metabolic process • regulation of fatty acid biosynthetic process • monocarboxylic acid metabolic process • positive regulation of unsaturated fatty acid biosynthetic process • regulation of prostaglandin biosynthetic process • icosanoid metabolic process • ketone metabolic process • regulation of unsaturated fatty acid biosynthetic process • positive regulation of fatty acid biosynthetic process • prostanoid metabolic process • icosanoid biosynthetic process • prostanoid biosynthetic process • positive regulation of fatty acid metabolic process • fatty acid metabolic process • monocarboxylic acid biosynthetic process • carboxylic acid metabolic process • fatty acid biosynthetic process • unsaturated fatty acid biosynthetic process • positive regulation of cell population proliferation • regulation of cell population proliferation • maternal aggressive behavior • aggressive behavior • biological process involved in intraspecies interaction between organisms • social behavior • intracellular signal transduction • positive regulation of systemic arterial blood pressure • regulation of systemic arterial blood pressure • regulation of blood pressure • positive regulation of blood pressure • response to nicotine • regulation of glutamate secretion • positive regulation of secretion by cell • positive regulation of amine transport • positive regulation of secretion • regulation of amino acid transport • glutamate secretion • organic anion transport • carboxylic acid transport • positive regulation of glutamate secretion • positive regulation of organic acid transport • organic acid transport • amino acid transport • amine transport • acidic amino acid transport • positive regulation of transport • positive regulation of amino acid transport • regulation of organic acid transport • dicarboxylic acid transport • regulation of amine transport • grooming behavior • dense core granule • secretory granule • secretory vesicle • neuronal dense core vesicle
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30518
Sequence	>7DW9_nogp_Chain_R T R D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G H W A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D R F R G P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R P M L A Y R H G S G A H W N R P V L V A W A F S L L L S L P Q L F I F A Q R N V E V T D C W A C F A E P W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D P E A P L E G A P F V L L M L L A S L N S C T N P W I Y A S F S S S V S S E L R S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	7R0C	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Arrestin2	4.73	2022-09-14	10.1126/sciadv.abo7761
	7DW9	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	chim(NtGi1-Gs)/β1/γ2	2.6	2021-07-21	10.1038/s41422-021-00480-2
	7DW9 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		2.6	2021-07-21	10.1038/s41422-021-00480-2
	7BB7	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Gs/β1/γ2	4.4	2021-06-02	10.1126/sciadv.abg5628
	7BB7 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		4.4	2021-06-02	10.1126/sciadv.abg5628
	7BB6	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Gs/β1/γ2	4.2	2021-06-02	10.1126/sciadv.abg5628
	7BB6 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		4.2	2021-06-02	10.1126/sciadv.abg5628
	7KH0	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	chim(NtGi1-Gs)/β1/γ2	2.8	2021-05-26	10.1038/s41422-021-00483-z
	7KH0 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		2.8	2021-05-26	10.1038/s41422-021-00483-z
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	10.1126/science.1215904
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	10.1126/science.1215904

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