psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D33	R:R:P34	4.83	No	No	0	6	4
2	L:L:P7	R:R:L36	3.28	No	No	0	0	4
3	R:R:L41	R:R:R38	3.64	No	No	0	4	5
4	R:R:E40	R:R:L43	3.98	No	No	0	5	5
5	R:R:E40	R:R:Q96	6.37	No	Yes	0	5	7
6	R:R:A42	R:R:L312	3.15	No	Yes	0	5	4
7	R:R:L312	R:R:L43	5.54	Yes	No	0	4	5
8	R:R:L44	R:R:Q96	5.32	No	Yes	0	7	7
9	R:R:I46	R:R:Q92	9.61	No	No	0	4	6
10	R:R:I46	R:R:S315	6.19	No	No	0	4	7
11	R:R:A89	R:R:V47	5.09	No	Yes	0	7	7
12	R:R:V47	R:R:V93	4.81	Yes	No	0	7	7
13	R:R:C319	R:R:V49	5.12	No	No	0	7	5
14	R:R:S54	R:R:V51	4.85	No	No	0	8	7
15	R:R:L53	R:R:P322	9.85	No	No	0	4	9
16	R:R:C82	R:R:S54	3.44	No	No	0	9	8
17	R:R:L86	R:R:S54	7.51	No	No	0	7	8
18	R:R:G56	R:R:N55	3.39	No	No	0	3	9
19	R:R:C82	R:R:L57	4.76	No	No	0	9	5
20	R:R:L57	R:R:L83	5.54	No	No	0	5	6
21	R:R:L62	R:R:V58	2.98	No	No	0	7	8
22	R:R:L59	R:R:S334	10.51	No	No	0	7	5
23	R:R:L59	R:R:S338	7.51	No	No	0	7	5
24	R:R:A60	R:R:H75	4.39	No	Yes	0	3	9
25	R:R:P73	R:R:R64	12.97	No	No	0	7	6
26	R:R:H75	R:R:R64	14.67	Yes	No	0	9	6
27	R:R:H70	R:R:W71	5.29	No	No	0	8	7
28	R:R:H70	R:R:V160	2.77	No	No	0	8	7
29	R:R:R158	R:R:W71	4	Yes	No	0	3	7
30	R:R:P73	R:R:V76	8.84	No	No	0	7	4
31	R:R:H75	R:R:I74	5.3	Yes	No	0	9	8
32	R:R:I74	R:R:S330	3.1	No	No	0	8	5
33	R:R:H75	R:R:I78	2.65	Yes	No	0	9	8
34	R:R:H80	R:R:V76	6.92	No	No	0	9	4
35	R:R:F77	R:R:H80	3.39	Yes	No	0	8	9
36	R:R:F77	R:R:M129	11.2	Yes	Yes	0	8	8
37	R:R:F77	R:R:M133	4.98	Yes	No	0	8	9
38	R:R:F77	R:R:V160	5.24	Yes	No	0	8	7
39	R:R:I78	R:R:L81	4.28	No	Yes	0	8	9
40	R:R:I78	R:R:Y325	6.04	No	Yes	0	8	9
41	R:R:D85	R:R:L81	5.43	Yes	Yes	4	9	9
42	R:R:L81	R:R:M129	5.65	Yes	Yes	0	9	8
43	R:R:L81	R:R:N321	10.98	Yes	Yes	4	9	9
44	R:R:A84	R:R:M129	3.22	No	Yes	0	8	8
45	R:R:D85	R:R:S126	4.42	Yes	No	4	9	9
46	R:R:D85	R:R:S318	11.78	Yes	No	4	9	9
47	R:R:D85	R:R:N321	2.69	Yes	Yes	4	9	9
48	R:R:L86	R:R:L90	2.77	No	No	0	7	5
49	R:R:A87	R:R:F91	4.16	No	No	0	6	4
50	R:R:M123	R:R:V88	4.56	Yes	No	0	7	7
51	R:R:F91	R:R:L90	3.65	No	No	0	4	5
52	R:R:F91	R:R:L118	14.61	No	No	0	4	5
53	R:R:Q92	R:R:Q96	5.12	No	Yes	0	6	7
54	R:R:Q119	R:R:Q92	5.12	Yes	No	0	7	6
55	R:R:L94	R:R:P95	3.28	No	Yes	0	8	5
56	R:R:P95	R:R:W99	2.7	Yes	Yes	1	5	5
57	R:R:K116	R:R:P95	5.02	Yes	Yes	1	6	5
58	R:R:P95	R:R:Q119	3.16	Yes	Yes	1	5	7
59	R:R:L97	R:R:Q96	5.32	No	Yes	0	6	7
60	R:R:R104	R:R:W99	3	Yes	Yes	1	4	5
61	R:R:F105	R:R:W99	5.01	Yes	Yes	0	8	5
62	R:R:C112	R:R:W99	2.61	No	Yes	1	9	5
63	R:R:C192	R:R:W99	3.92	No	Yes	1	9	5
64	R:R:R104	R:R:T102	3.88	Yes	No	0	4	5
65	R:R:D103	R:R:F105	16.72	No	Yes	0	5	8
66	R:R:P108	R:R:R104	4.32	No	Yes	1	8	4
67	R:R:L111	R:R:R104	4.86	No	Yes	1	5	4
68	R:R:F105	R:R:R106	3.21	Yes	Yes	0	8	3
69	R:R:D191	R:R:F105	8.36	No	Yes	0	4	8
70	R:R:N182	R:R:R106	6.03	No	Yes	1	3	3
71	R:R:R106	R:R:V189	2.62	Yes	No	0	3	3
72	R:R:R106	R:R:T190	12.94	Yes	No	1	3	4
73	R:R:G107	R:R:P108	4.06	No	No	0	6	8
74	R:R:L111	R:R:P108	13.14	No	No	1	5	8
75	R:R:D109	R:R:L111	2.71	No	No	0	4	5
76	R:R:A110	R:R:R113	5.53	No	No	0	2	7
77	R:R:C112	R:R:C192	7.28	No	No	1	9	9
78	R:R:Q180	R:R:R113	12.85	No	No	0	4	7
79	R:R:K116	R:R:V115	3.04	Yes	No	0	6	5
80	R:R:K116	R:R:Q119	2.71	Yes	Yes	1	6	7
81	R:R:F178	R:R:K116	6.2	No	Yes	0	6	6
82	R:R:V121	R:R:Y117	8.83	No	No	2	5	5
83	R:R:S171	R:R:Y117	10.17	Yes	No	2	7	5
84	R:R:M123	R:R:Q119	2.72	Yes	Yes	1	7	7
85	R:R:M120	R:R:Y124	4.79	No	Yes	2	5	7
86	R:R:M120	R:R:Q174	13.59	No	Yes	2	5	5
87	R:R:G122	R:R:V121	3.68	No	No	0	8	5
88	R:R:S171	R:R:V121	3.23	Yes	No	2	7	5
89	R:R:M123	R:R:S315	3.07	Yes	No	1	7	7
90	L:L:Y2	R:R:M123	9.58	Yes	Yes	1	0	7
91	R:R:S127	R:R:Y124	12.72	No	Yes	2	8	7
92	R:R:Y124	R:R:Y128	9.93	Yes	Yes	2	7	6
93	R:R:S167	R:R:Y124	7.63	No	Yes	0	8	7
94	R:R:Q174	R:R:Y124	3.38	Yes	Yes	2	5	7
95	R:R:I209	R:R:Y124	3.63	No	Yes	0	5	7
96	R:R:V213	R:R:Y124	3.79	Yes	Yes	2	5	7
97	R:R:S126	R:R:S318	3.26	No	No	4	9	9
98	R:R:S127	R:R:Y128	6.36	No	Yes	2	8	6
99	R:R:S127	R:R:V213	6.46	No	Yes	2	8	5
100	R:R:L131	R:R:Y128	7.03	No	Yes	0	7	6
101	R:R:F166	R:R:Y128	14.44	No	Yes	0	3	6
102	R:R:M212	R:R:Y128	5.99	No	Yes	2	3	6
103	R:R:V213	R:R:Y128	7.57	Yes	Yes	2	5	6
104	R:R:M129	R:R:W164	4.65	Yes	No	0	8	9
105	R:R:I130	R:R:Y280	12.09	No	No	0	8	9
106	R:R:I130	R:R:Y325	4.84	No	Yes	0	8	9
107	R:R:L131	R:R:L135	4.15	No	No	0	7	6
108	R:R:A216	R:R:L131	4.73	No	No	0	5	7
109	R:R:M133	R:R:R137	6.2	No	Yes	4	9	9
110	R:R:M133	R:R:Y325	3.59	No	Yes	4	9	9
111	R:R:R137	R:R:T134	3.88	Yes	No	0	9	8
112	R:R:P217	R:R:T134	5.25	No	No	0	9	8
113	R:R:A140	R:R:D136	4.63	No	No	0	8	9
114	R:R:R137	R:R:Y325	7.2	Yes	Yes	4	9	9
115	R:R:H138	R:R:R139	5.64	No	No	0	8	5
116	R:R:I141	R:R:L227	2.85	No	No	0	8	4
117	R:R:P144	R:R:R143	4.32	No	No	0	9	6
118	R:R:N157	R:R:R158	8.44	No	Yes	0	4	3
119	R:R:R158	R:R:V162	6.54	Yes	No	0	3	3
120	R:R:L161	R:R:V160	4.47	No	No	0	2	7
121	R:R:A165	R:R:W164	2.59	No	No	0	3	9
122	R:R:A165	R:R:L168	3.15	No	No	0	3	4
123	R:R:F166	R:R:L169	9.74	No	No	0	3	4
124	R:R:L168	R:R:S171	4.5	No	Yes	0	4	7
125	R:R:L170	R:R:Q174	6.65	No	Yes	0	4	5
126	R:R:L170	R:R:V206	4.47	No	No	0	4	5
127	R:R:I209	R:R:L170	4.28	No	No	0	5	4
128	R:R:Q174	R:R:S171	4.33	Yes	Yes	2	5	7
129	R:R:L172	R:R:P173	4.93	No	No	0	4	8
130	R:R:F176	R:R:L172	4.87	No	No	0	4	4
131	R:R:E198	R:R:F176	3.5	No	No	0	4	4
132	R:R:E198	R:R:I177	4.1	No	No	0	4	5
133	R:R:A179	R:R:C195	3.61	No	No	0	4	2
134	R:R:C195	R:R:R181	11.14	No	No	0	2	1
135	R:R:A197	R:R:R181	5.53	No	No	0	5	1
136	R:R:N182	R:R:T190	8.77	No	No	1	3	4
137	R:R:C192	R:R:N182	4.72	No	No	1	9	3
138	R:R:D191	R:R:W193	6.7	No	No	0	4	4
139	L:L:Q4	R:R:W193	28.48	No	No	0	0	4
140	L:L:Q4	R:R:A194	6.06	No	No	0	0	5
141	R:R:F196	R:R:P199	4.33	Yes	No	0	5	3
142	R:R:F196	R:R:W200	5.01	Yes	No	0	5	1
143	R:R:E299	R:R:F196	5.83	No	Yes	0	2	5
144	R:R:R202	R:R:Y205	3.09	No	No	0	4	7
145	R:R:R203	R:R:T204	5.17	No	No	0	4	3
146	R:R:P298	R:R:R203	14.41	No	No	0	3	4
147	R:R:T204	R:R:T207	9.42	No	No	5	3	5
148	R:R:T204	R:R:W208	14.55	No	No	5	3	3
149	R:R:T207	R:R:W208	10.92	No	No	5	5	3
150	R:R:L211	R:R:W208	3.42	No	No	0	5	3
151	R:R:I209	R:R:M212	2.92	No	No	0	5	3
152	R:R:A210	R:R:Q291	4.55	No	Yes	0	5	6
153	R:R:F288	R:R:L211	6.09	Yes	No	0	7	5
154	R:R:M212	R:R:V213	4.56	No	Yes	2	3	5
155	R:R:F214	R:R:V215	2.62	Yes	No	3	8	4
156	R:R:F214	R:R:V281	5.24	Yes	No	0	8	5
157	R:R:F214	R:R:W284	11.02	Yes	Yes	3	8	8
158	R:R:F214	R:R:F288	26.79	Yes	Yes	3	8	7
159	R:R:F288	R:R:V215	2.62	Yes	No	3	7	4
160	R:R:P217	R:R:Y280	6.95	No	No	0	9	9
161	R:R:C224	R:R:I221	3.27	No	Yes	0	5	8
162	R:R:I221	R:R:T273	3.04	Yes	No	0	8	8
163	R:R:I221	R:R:V277	4.61	Yes	No	0	8	8
164	R:R:Q225	R:R:V270	12.89	No	No	0	9	6
165	R:R:F229	R:R:R230	11.76	No	No	0	5	4
166	R:R:I232	R:R:V266	6.14	No	No	0	9	7
167	R:R:A234	R:R:H233	4.39	No	No	0	4	4
168	R:R:V262	R:R:V266	3.21	No	No	0	5	7
169	R:R:A265	R:R:K268	3.21	No	No	0	7	8
170	R:R:K268	R:R:M272	2.88	No	Yes	0	8	8
171	R:R:L274	R:R:R271	4.86	No	No	0	5	7
172	R:R:M272	R:R:V275	7.61	Yes	No	0	8	6
173	R:R:I276	R:R:M272	2.92	No	Yes	0	8	8
174	R:R:F328	R:R:M272	9.95	No	Yes	0	7	8
175	R:R:L274	R:R:V278	2.98	No	No	0	5	4
176	R:R:I324	R:R:V279	7.68	No	No	0	8	6
177	R:R:W284	R:R:Y280	21.22	Yes	No	0	8	9
178	R:R:C283	R:R:T320	3.38	No	No	0	8	6
179	R:R:F287	R:R:W284	29.06	No	Yes	3	6	8
180	R:R:N317	R:R:W284	14.69	No	Yes	3	9	8
181	R:R:L310	R:R:P286	3.28	Yes	No	0	5	9
182	R:R:L313	R:R:P286	8.21	No	No	0	7	9
183	R:R:A314	R:R:F287	6.93	No	No	0	7	6
184	R:R:F287	R:R:N317	6.04	No	No	3	6	9
185	R:R:F288	R:R:Q291	3.51	Yes	Yes	3	7	6
186	R:R:L289	R:R:L310	6.92	No	Yes	0	5	5
187	R:R:Q291	R:R:V290	5.73	Yes	No	3	6	5
188	R:R:L310	R:R:V290	4.47	Yes	No	0	5	5
189	L:L:F3	R:R:V290	2.62	No	No	3	0	5
190	R:R:L292	R:R:Q291	2.66	No	Yes	0	5	6
191	L:L:F3	R:R:Q291	3.51	No	Yes	3	0	6
192	R:R:A295	R:R:P301	5.61	No	No	0	5	4
193	R:R:D297	R:R:L302	2.71	Yes	No	0	3	3
194	L:L:R8	R:R:E303	8.14	No	No	0	0	4
195	R:R:F307	R:R:L310	3.65	Yes	Yes	0	5	5
196	R:R:F307	R:R:M311	12.44	Yes	No	0	5	5
197	L:L:N5	R:R:F307	7.25	No	Yes	0	0	5
198	L:L:Y2	R:R:M311	10.78	Yes	No	0	0	5
199	L:L:Y2	R:R:A314	2.67	Yes	No	0	0	7
200	L:L:Y2	R:R:S315	7.63	Yes	No	1	0	7
201	R:R:C319	R:R:L316	4.76	No	No	0	7	6
202	R:R:T320	R:R:W323	6.06	No	No	0	6	6
203	R:R:N321	R:R:P322	4.89	Yes	No	0	9	9
204	R:R:N321	R:R:Y325	8.14	Yes	Yes	4	9	9
205	R:R:I324	R:R:W323	4.7	No	No	0	8	6
206	R:R:S327	R:R:W323	4.94	No	No	0	5	6
207	R:R:I324	R:R:Y325	3.63	No	Yes	0	8	9
208	R:R:A326	R:R:S331	3.42	No	No	0	7	7
209	R:R:F328	R:R:S327	5.28	No	No	0	7	5
210	R:R:F328	R:R:S329	2.64	No	No	0	7	8
211	R:R:S330	R:R:S331	3.26	No	No	0	5	7
212	R:R:S331	R:R:S334	6.52	No	No	0	7	5
213	R:R:E335	R:R:L339	3.98	No	No	0	6	4
214	L:L:C1	L:L:C6	5.46	No	No	0	0	0
215	L:L:C6	L:L:P7	3.77	No	No	0	0	0
216	R:R:I221	R:R:R137	2.51	Yes	Yes	0	8	9
217	R:R:E299	R:R:R203	2.33	No	No	0	2	4
218	R:R:R139	R:R:R143	2.13	No	No	0	5	6
219	R:R:G185	R:R:G186	2.11	No	No	0	1	1
220	R:R:G304	R:R:P306	2.03	No	No	0	4	4
221	R:R:A125	R:R:G122	1.95	No	No	0	7	8
222	R:R:A223	R:R:G220	1.95	No	No	0	4	6
223	R:R:A72	R:R:P73	1.87	No	No	0	7	7
224	R:R:A285	R:R:P286	1.87	No	No	0	6	9
225	R:R:A294	R:R:P301	1.87	No	No	0	4	4
226	R:R:A300	R:R:P301	1.87	No	No	0	1	4
227	R:R:A305	R:R:P306	1.87	No	No	0	2	4
228	R:R:G186	R:R:S187	1.86	No	No	0	1	1
229	R:R:A50	R:R:A89	1.79	No	No	0	6	7
230	R:R:A110	R:R:A114	1.79	No	No	0	2	4
231	R:R:A132	R:R:A163	1.79	No	No	0	7	7
232	R:R:G56	R:R:L59	1.71	No	No	0	3	7
233	R:R:A63	R:R:S334	1.71	No	No	0	2	5
234	R:R:A264	R:R:S263	1.71	No	No	0	5	4
235	R:R:A39	R:R:V308	1.7	No	No	0	4	4
236	R:R:C142	R:R:I141	1.64	No	No	0	6	8
237	R:R:E303	R:R:G304	1.64	No	No	0	4	4
238	R:R:S45	R:R:V49	1.62	No	No	0	5	5
239	R:R:S187	R:R:V189	1.62	No	No	0	1	3
240	R:R:D297	R:R:P298	1.61	Yes	No	0	3	3
241	R:R:V47	R:R:V51	1.6	Yes	No	0	7	7
242	R:R:V278	R:R:V281	1.6	No	No	0	4	5
243	R:R:C319	R:R:L53	1.59	No	No	0	7	4
244	R:R:G79	R:R:H75	1.59	No	Yes	0	5	9
245	R:R:G220	R:R:H138	1.59	No	No	0	6	8
246	R:R:T269	R:R:V270	1.59	No	No	0	7	6
247	R:R:C283	R:R:L316	1.59	No	No	0	8	6
248	R:R:A132	R:R:L135	1.58	No	No	0	7	6
249	L:L:P7	R:R:E40	1.57	No	No	0	0	5
250	R:R:E198	R:R:P199	1.57	No	No	0	4	3
251	R:R:A37	R:R:D33	1.54	No	No	0	5	6
252	R:R:I46	R:R:V47	1.54	No	Yes	0	4	7
253	R:R:A295	R:R:D297	1.54	No	Yes	0	5	3
254	R:R:A300	R:R:D297	1.54	No	Yes	0	1	3
255	R:R:C112	R:R:Q180	1.53	No	No	0	9	4
256	R:R:I228	R:R:T269	1.52	No	No	0	8	7
257	R:R:F307	R:R:G304	1.51	Yes	No	0	5	4
258	R:R:G66	R:R:R67	1.5	No	No	0	8	6
259	L:L:G9	L:L:R8	1.5	No	No	0	0	0
260	R:R:L312	R:R:V308	1.49	Yes	No	0	4	4
261	R:R:L336	R:R:V332	1.49	No	No	0	6	8
262	R:R:C224	R:R:H138	1.47	No	No	0	5	8
263	R:R:A61	R:R:H75	1.46	No	Yes	0	7	9
264	R:R:D191	R:R:V183	1.46	No	No	0	4	1
265	R:R:P159	R:R:R158	1.44	No	Yes	0	6	3
266	R:R:E184	R:R:T190	1.41	No	No	0	1	4
267	R:R:G201	R:R:W200	1.41	No	No	0	3	1
268	R:R:C142	R:R:R143	1.39	No	No	0	6	6
269	R:R:A98	R:R:R104	1.38	No	Yes	0	4	4
270	R:R:H261	R:R:V262	1.38	No	No	0	3	5
271	R:R:L309	R:R:L312	1.38	No	Yes	0	4	4
272	R:R:L309	R:R:L313	1.38	No	No	0	4	7
273	R:R:E335	R:R:L336	1.33	No	No	0	6	6
274	R:R:R230	R:R:V226	1.31	No	No	0	4	3
275	R:R:F229	R:R:I232	1.26	No	No	0	5	9
276	R:R:I74	R:R:R67	1.25	No	No	0	8	6
277	R:R:D136	R:R:R139	1.19	No	No	0	9	5
278	R:R:L175	R:R:Y117	1.17	No	No	0	4	5
279	R:R:F229	R:R:Q225	1.17	No	No	0	5	9
280	R:R:R64	R:R:R68	1.07	No	No	0	6	6
281	R:R:F196	R:R:R181	1.07	Yes	No	0	5	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V47	3.26	4	0	7
2	R:R:H75	5.01	6	0	9
3	R:R:F77	6.2025	4	0	8
4	R:R:L81	6.585	4	4	9
5	R:R:D85	6.08	4	4	9
6	R:R:P95	3.54	4	1	5
7	R:R:Q96	5.5325	4	0	7
8	R:R:W99	3.448	5	1	5
9	R:R:R104	3.488	5	1	4
10	R:R:F105	8.325	4	0	8
11	R:R:R106	6.2	4	1	3
12	R:R:K116	4.2425	4	1	6
13	R:R:Q119	3.4275	4	1	7
14	R:R:M123	4.9825	4	1	7
15	R:R:Y124	6.55286	7	2	7
16	R:R:Y128	8.55333	6	2	6
17	R:R:M129	6.18	4	0	8
18	R:R:R137	4.9475	4	4	9
19	R:R:R158	5.105	4	0	3
20	R:R:S171	5.5575	4	2	7
21	R:R:Q174	6.9875	4	2	5
22	R:R:F196	4.06	4	0	5
23	R:R:V213	5.595	4	2	5
24	R:R:F214	11.4175	4	3	8
25	R:R:I221	3.3575	4	0	8
26	R:R:M272	5.84	4	0	8
27	R:R:W284	18.9975	4	3	8
28	R:R:F288	9.7525	4	3	7
29	R:R:Q291	3.992	5	3	6
30	R:R:D297	1.85	4	0	3
31	R:R:F307	6.2125	4	0	5
32	R:R:L310	4.58	4	0	5
33	R:R:L312	2.89	4	0	4
34	R:R:N321	6.675	4	4	9
35	R:R:Y325	5.57333	6	4	9
36	L:L:Y2	7.665	4	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E40	R:R:Q96	12.2802	6.37	No	Yes	0	5	7
2	R:R:Q92	R:R:Q96	18.1297	5.12	No	Yes	0	6	7
3	R:R:I46	R:R:Q92	11.4472	9.61	No	No	0	4	6
4	R:R:I46	R:R:S315	22.7759	6.19	No	No	0	4	7
5	R:R:I46	R:R:V47	16.1157	1.54	No	Yes	0	4	7
6	L:L:Y2	R:R:S315	23.4978	7.63	Yes	No	1	0	7
7	L:L:Y2	R:R:A314	71.0192	2.67	Yes	No	0	0	7
8	R:R:A314	R:R:F287	71.5079	6.93	No	No	0	7	6
9	R:R:F287	R:R:W284	71.6116	29.06	No	Yes	3	6	8
10	R:R:W284	R:R:Y280	100	21.22	Yes	No	0	8	9
11	R:R:I130	R:R:Y280	91.0814	12.09	No	No	0	8	9
12	R:R:I130	R:R:Y325	91.1777	4.84	No	Yes	0	8	9
13	R:R:N321	R:R:Y325	26.678	8.14	Yes	Yes	4	9	9
14	R:R:Q119	R:R:Q92	12.8022	5.12	Yes	No	0	7	6
15	R:R:M123	R:R:Q119	43.5674	2.72	Yes	Yes	1	7	7
16	L:L:Y2	R:R:M123	44.9335	9.58	Yes	Yes	1	0	7
17	R:R:V47	R:R:V51	11.6582	1.6	Yes	No	0	7	7
18	R:R:S54	R:R:V51	10.5253	4.85	No	No	0	8	7
19	R:R:I78	R:R:Y325	34.1602	6.04	No	Yes	0	8	9
20	R:R:H75	R:R:I78	17.4966	2.65	Yes	No	0	9	8
21	R:R:H75	R:R:I74	11.3694	5.3	Yes	No	0	9	8
22	R:R:M133	R:R:Y325	26.678	3.59	No	Yes	4	9	9
23	R:R:F77	R:R:M133	29.2103	4.98	Yes	No	0	8	9
24	R:R:I78	R:R:L81	23.2794	4.28	No	Yes	0	8	9
25	R:R:L81	R:R:M129	42.6012	5.65	Yes	Yes	0	9	8
26	R:R:L81	R:R:N321	21.3876	10.98	Yes	Yes	4	9	9
27	R:R:F77	R:R:M129	23.8088	11.2	Yes	Yes	0	8	8
28	R:R:P95	R:R:Q119	35.1338	3.16	Yes	Yes	1	5	7
29	R:R:P95	R:R:W99	33.6085	2.7	Yes	Yes	1	5	5
30	R:R:F105	R:R:W99	15.8158	5.01	Yes	Yes	0	8	5
31	R:R:M129	R:R:W164	60.7049	4.65	Yes	No	0	8	9
32	R:R:A165	R:R:W164	58.8538	2.59	No	No	0	3	9
33	R:R:A165	R:R:L168	56.9953	3.15	No	No	0	3	4
34	R:R:L168	R:R:S171	55.1294	4.5	No	Yes	0	4	7
35	R:R:Q174	R:R:S171	43.7785	4.33	Yes	Yes	2	5	7
36	R:R:Q174	R:R:Y124	31.9499	3.38	Yes	Yes	2	5	7
37	R:R:Y124	R:R:Y128	18.1148	9.93	Yes	Yes	2	7	6
38	R:R:L131	R:R:Y128	10.1847	7.03	No	Yes	0	7	6
39	R:R:R137	R:R:Y325	11.3657	7.2	Yes	Yes	4	9	9
40	R:R:I221	R:R:R137	20.836	2.51	Yes	Yes	0	8	9
41	R:R:C224	R:R:I221	16.9561	3.27	No	Yes	0	5	8
42	R:R:C224	R:R:H138	15.5751	1.47	No	No	0	5	8
43	R:R:H138	R:R:R139	11.4213	5.64	No	No	0	8	5
44	R:R:L310	R:R:V290	12.1284	4.47	Yes	No	0	5	5
45	R:R:Q291	R:R:V290	12.3135	5.73	Yes	No	3	6	5
46	R:R:F288	R:R:Q291	14.7458	3.51	Yes	Yes	3	7	6
47	R:R:F288	R:R:L211	31.0947	6.09	Yes	No	0	7	5
48	R:R:L211	R:R:W208	30.084	3.42	No	No	0	5	3
49	R:R:T204	R:R:W208	27.9479	14.55	No	No	5	3	3
50	R:R:R203	R:R:T204	27.0075	5.17	No	No	0	4	3
51	R:R:E299	R:R:R203	16.2711	2.33	No	No	0	2	4
52	R:R:E299	R:R:F196	15.1568	5.83	No	Yes	0	2	5
53	R:R:P298	R:R:R203	10.6253	14.41	No	No	0	3	4
54	R:R:F214	R:R:W284	45.2927	11.02	Yes	Yes	3	8	8
55	R:R:I324	R:R:Y325	15.0457	3.63	No	Yes	0	8	9
56	R:R:I324	R:R:W323	12.9466	4.7	No	No	0	8	6
57	L:L:Y2	R:R:M311	11.499	10.78	Yes	No	0	0	5
58	R:R:F307	R:R:M311	10.6586	12.44	Yes	No	0	5	5
59	R:R:F214	R:R:F288	40.1873	26.79	Yes	Yes	3	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:P7	R:R:L36	3.28	0	No	No	0	4	0	1
R:R:E40	R:R:L43	3.98	0	No	No	5	5	1	2
R:R:E40	R:R:Q96	6.37	0	No	Yes	5	7	1	2
R:R:I46	R:R:S315	6.19	0	No	No	4	7	2	1
R:R:M123	R:R:V88	4.56	1	Yes	No	7	7	1	2
R:R:M123	R:R:Q119	2.72	1	Yes	Yes	7	7	1	2
R:R:M123	R:R:S315	3.07	1	Yes	No	7	7	1	1
L:L:Y2	R:R:M123	9.58	1	Yes	Yes	0	7	0	1
R:R:D191	R:R:W193	6.7	0	No	No	4	4	2	1
L:L:Q4	R:R:W193	28.48	0	No	No	0	4	0	1
L:L:Q4	R:R:A194	6.06	0	No	No	0	5	0	1
R:R:A210	R:R:Q291	4.55	0	No	Yes	5	6	2	1
R:R:A314	R:R:F287	6.93	0	No	No	7	6	1	2
R:R:F288	R:R:Q291	3.51	3	Yes	Yes	7	6	2	1
R:R:Q291	R:R:V290	5.73	3	Yes	No	6	5	1	1
R:R:L310	R:R:V290	4.47	0	Yes	No	5	5	2	1
L:L:F3	R:R:V290	2.62	3	No	No	0	5	0	1
R:R:L292	R:R:Q291	2.66	0	No	Yes	5	6	2	1
L:L:F3	R:R:Q291	3.51	3	No	Yes	0	6	0	1
L:L:R8	R:R:E303	8.14	0	No	No	0	4	0	1
R:R:F307	R:R:L310	3.65	0	Yes	Yes	5	5	1	2
R:R:F307	R:R:M311	12.44	0	Yes	No	5	5	1	1
L:L:N5	R:R:F307	7.25	0	No	Yes	0	5	0	1
L:L:Y2	R:R:M311	10.78	1	Yes	No	0	5	0	1
L:L:Y2	R:R:A314	2.67	1	Yes	No	0	7	0	1
L:L:Y2	R:R:S315	7.63	1	Yes	No	0	7	0	1
R:R:E303	R:R:G304	1.64	0	No	No	4	4	1	2
L:L:P7	R:R:E40	1.57	0	No	No	0	5	0	1
R:R:F307	R:R:G304	1.51	0	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7BB6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.59
Number of Linked Nodes	260
Number of Links	281
Number of Hubs	36
Number of Links mediated by Hubs	130
Number of Communities	5
Number of Nodes involved in Communities	45
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	60
Number Of Links MetaPath	59
Number of Shortest Paths	43173
Length Of Smallest Path	3
Average Path Length	15.8605
Length of Longest Path	31
Minimum Path Strength	1.215
Average Path Strength	7.04396
Maximum Path Strength	25.14
Minimum Path Correlation	0.7
Average Path Correlation	0.939951
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	56.8409
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.3787
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• regulation of body fluid levels • hemostasis • biological regulation • regulation of biological quality • regulation of tube diameter • multicellular organismal process • regulation of biological process • system process • regulation of tube size • regulation of system process • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • regulation of biosynthetic process • regulation of cellular process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • cellular process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • cellular response to stimulus • response to stimulus • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • response to peptide • response to cytokine • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of systemic arterial blood pressure • endocrine process • regulation of systemic arterial blood pressure by vasopressin • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of cell communication • regulation of signaling • positive regulation of signal transduction • positive regulation of intracellular signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • renal system process • regulation of urine volume • renal water retention • negative regulation of urine volume • developmental process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • telencephalon development • system development • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • positive regulation of systemic arterial blood pressure • positive regulation of blood pressure • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • intracellular membrane-bounded organelle • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle • cytoplasm • organelle membrane • cell periphery • plasma membrane • Golgi apparatus • endomembrane system • endosome • perinuclear region of cytoplasm • endoplasmic reticulum • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • synapse • cell junction • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • G-protein beta-subunit binding • fibroblast proliferation • vasopressin receptor binding • V1B vasopressin receptor binding • molecular transducer activity • signaling receptor activity • neuropeptide activity • signaling receptor activator activity • hormone activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • neurohypophyseal hormone activity • V1A vasopressin receptor binding • catalytic activity, acting on a protein • kinase activity • protein kinase activity • transferase activity • phosphotransferase activity, alcohol group as acceptor • transferase activity, transferring phosphorus-containing groups • regulation of growth • regulation of cellular component organization • positive regulation of cell growth • regulation of cell growth • cell growth • cellular component organization • positive regulation of growth • cellular component organization or biogenesis • positive regulation of cytosolic calcium ion concentration • behavior • locomotory behavior • reproductive process • negative regulation of female receptivity • multicellular organismal reproductive process • female mating behavior • mating behavior • regulation of female receptivity • reproductive behavior • negative regulation of nervous system process • regulation of system process • transmission of nerve impulse • negative regulation of transmission of nerve impulse • negative regulation of cell communication • regulation of nervous system process • regulation of transmission of nerve impulse • negative regulation of cellular process • negative regulation of multicellular organismal process • regulation of tube diameter • regulation of tube size • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • response to testosterone • biological process involved in interspecies interaction between organisms • symbiont entry into host cell • viral process • symbiont entry into host • viral life cycle • biological process involved in interaction with host • biological process involved in symbiotic interaction • maternal behavior • parental behavior • fluid transport • water transport • generation of precursor metabolites and energy • positive regulation of cellular pH reduction • intracellular pH reduction • regulation of intracellular pH • cellular homeostasis • regulation of cellular pH reduction • intracellular monoatomic cation homeostasis • regulation of pH • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • regulation of cellular pH • intracellular monoatomic ion homeostasis • response to ethanol • prostaglandin metabolic process • unsaturated fatty acid metabolic process • oxoacid metabolic process • regulation of lipid metabolic process • organic acid biosynthetic process • organic acid metabolic process • carboxylic acid biosynthetic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • positive regulation of prostaglandin biosynthetic process • small molecule metabolic process • prostaglandin biosynthetic process • primary metabolic process • regulation of ketone metabolic process • regulation of fatty acid metabolic process • regulation of fatty acid biosynthetic process • monocarboxylic acid metabolic process • positive regulation of unsaturated fatty acid biosynthetic process • regulation of prostaglandin biosynthetic process • icosanoid metabolic process • ketone metabolic process • regulation of unsaturated fatty acid biosynthetic process • lipid biosynthetic process • positive regulation of fatty acid biosynthetic process • prostanoid metabolic process • icosanoid biosynthetic process • prostanoid biosynthetic process • positive regulation of fatty acid metabolic process • fatty acid metabolic process • monocarboxylic acid biosynthetic process • small molecule biosynthetic process • carboxylic acid metabolic process • fatty acid biosynthetic process • unsaturated fatty acid biosynthetic process • positive regulation of lipid biosynthetic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • lipid metabolic process • positive regulation of cell population proliferation • regulation of cell population proliferation • maternal aggressive behavior • aggressive behavior • biological process involved in intraspecies interaction between organisms • social behavior • positive regulation of systemic arterial blood pressure • regulation of systemic arterial blood pressure • regulation of blood pressure • positive regulation of blood pressure • response to nicotine • regulation of glutamate secretion • positive regulation of secretion by cell • positive regulation of amine transport • positive regulation of secretion • regulation of amino acid transport • glutamate secretion • organic anion transport • carboxylic acid transport • positive regulation of glutamate secretion • positive regulation of organic acid transport • organic acid transport • amino acid transport • amine transport • acidic amino acid transport • positive regulation of transport • positive regulation of amino acid transport • regulation of organic acid transport • dicarboxylic acid transport • regulation of amine transport • grooming behavior • dense core granule • secretory granule • secretory vesicle • neuronal dense core vesicle • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30518
Sequence	>7BB6_nogp_Chain_R D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G H W A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D R F R G P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R P N R P V L V A W A F S L L L S L P Q L F I F A Q R N V E G G S G V T D C W A C F A E P W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D P E A P L E G A P F V L L M L L A S L N S C T N P W I Y A S F S S S V S S E L R S L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IV2	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-	chim(NtGi1-Gs)/β1/γ2	3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	9IV2 (No Gprot)	B2	Adhesion	Adhesion	ADGRD1	Homo sapiens	5α-DHT	-		3.53	2025-02-12	doi.org/10.1016/j.cell.2025.01.006
	7R0C	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Arrestin2	4.73	2022-09-14	10.1126/sciadv.abo7761
	7DW9	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	chim(NtGi1-Gs)/β1/γ2	2.6	2021-07-21	10.1038/s41422-021-00480-2
	7DW9 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		2.6	2021-07-21	10.1038/s41422-021-00480-2
	7BB7	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Gs/β1/γ2	4.4	2021-06-02	10.1126/sciadv.abg5628
	7BB7 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		4.4	2021-06-02	10.1126/sciadv.abg5628
	7BB6	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	Gs/β1/γ2	4.2	2021-06-02	10.1126/sciadv.abg5628
	7BB6 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		4.2	2021-06-02	10.1126/sciadv.abg5628
	7KH0	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-	chim(NtGi1-Gs)/β1/γ2	2.8	2021-05-26	10.1038/s41422-021-00483-z
	7KH0 (No Gprot)	A	Peptide	Vasopressin and Oxytocin	V₂	Homo sapiens	AVP	-		2.8	2021-05-26	10.1038/s41422-021-00483-z
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	10.1126/science.1215904
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	10.1126/science.1215904

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